@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLA4: (2017-11-01 )
MKKIALFYMGGTFGCIGEPLAPMPYDQFLPQLEKVIPPHLTVDCFAAPNIVDSSACTAPDWLRLIQRIQQLQLEGYQHFVVIHGTDTLSYAAATLARFLGQSCHIVITGSQYPLLNIQGDNTREFTDAIENLYLALEQVIALLVGAYLAFHHQVFHAQTALKTHTTELDAFSGLSSNVEFTPQQNELIVQDAQIEKAASFQLLNWMMQPIATQHLVQQLRHLLPAPPHFLVLQGFGTGNIAVNDEFLATLDELYTRGCVPILATQVTFGGIDQRYAISTWAKTAKIVINDAHSHADLYAKALQIYLKYPTPEQWLNHWNENLH
Atome Classification :
(20 SA)
.........10...--..-...20---....------------..-------...-------30.....---------------------.--------------------------.-----.40...----....--.50........60........70..-.--.....80........90.....-...100.-..--.....110.......120.......130.......140---.....------..150.-------......160.......170-----------...-....180..-.--.----.--------.--.--190--.----...---.----.----...--200..---..---------....210-------...----------....-----220.......230.......240-.......250.......260........270.-.-......280.......290.......300......--.310.......320.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
K
I
A
L
F
Y
MGGTFG--CI-GEPL----APM
P
------------
Y
D
-------
Q
F
L
-------
P
Q
L
E
K
VI---------------------P--------------------------P-----H
L
T
V
D
C----FAAP--NIVDSSACT
A
P
D
W
L
R
L
I
Q
R
I
Q
Q
L
Q
L-E--G
Y
Q
H
F
V
V
I
HGTD
T
L
S
Y
A
A
A
T
L
A
-
R
F
LGQ-S-
C
H
--
I
V
I
TGSQY
P
L
L
N
IQGD
N
T
R
E
F
T
D
A
I
E
N
L
Y
L
A
L
E
Q
V
I
A
L
---
L
V
G
A
Y
------
L
A
F
H
H
Q
-------
V
F
H
A
Q
T
ALKTHTTE
L
D
A
FS-----------GLS-SN
V
E
FTPQQ-N--
E
----
L
--------
I
--
V
--Q----D----
A
Q
I
---
E
----
K
----
A
A
S
--
F
-
Q
L
L
---
N
W
---------
M
M
Q
P
I
A
T
-------
Q
H
L
----------
V
Q
Q
L
-----
R
H
LLPAPP
H
F
L
V
L
Q
GFGTG
N
I
A
V-
N
D
E
F
L
A
T
L
D
E
L
Y
TRGC
V
P
I
-
L
A
T
Q
V
TFGGI-D-Q-
R
Y
A
I
S
TWA
K
T
A
K
I
V
I
NDAH
S
H
A
D
L
Y
A
K
A
L
Q
I
Y
L
KY--P
T
P
E
Q
W
L
N
H
WNENLH
1
PsiBlast_PDB
85.73
27%
0
- C- -
-
3NTX
2
?
A:
[7-287]
-
K
S
I
Y
V
A
Y
T
G
G
T
I
G
--
M
Q
-
R
S
D
N
----
G
Y
I
P
------------
V
S
-------
G
H
L
Q
R
Q
L
A
L
M
P
E
F
H
R
P
E
---------------------
M
--------------------------
P
-----
D
F
T
I
H
E
----
Y
A
P
----
L
I
D
S
S
D
M
T
P
E
D
W
Q
H
I
A
N
D
I
Q
Q
-
N
Y
-
D
--
L
Y
D
G
F
V
I
L
H
G
T
D
T
M
A
F
T
A
S
A
L
S
-
F
M
L
E
N
-
L
-
A
K
P
-
V
I
I
T
G
S
Q
I
P
L
A
E
L
R
S
D
G
Q
---
T
N
L
L
N
A
L
Y
L
A
A
N
H
P
V
N
E
---
V
---
S
------
L
F
F
N
N
Q
-------
L
F
R
G
N
R
T
T
K
A
H
A
D
G
F
D
T
F
A
-------------
S
-
P
N
L
S
V
L
L
E
A
-
G
--
I
----
H
--------
I
--
R
--
R
----
Q
----
S
S
V
---
V
----
S
----
P
T
S
--
N
-
G
P
L
I
V
H
R
I
---------
T
P
Q
P
I
G
V
-------
V
T
I
----------
Y
P
G
I
S
G
A
V
V
R
N
F
L
L
Q
P
V
K
A
L
I
L
R
S
Y
G
V
G
N
A
P
Q
-
K
A
E
L
L
D
E
L
K
N
A
S
D
R
G
I
V
V
V
-
N
L
T
Q
C
I
S
G
S
V
-
N
-------------------------------------------------------
12
PsiBlast_PDB
75.59
26%
-57
- C2 -
-
5DND
3
?
A:
[32-373]
-
R
H
L
L
L
I
Y
T
G
G
T
L
G
M
Q
S
K
-
G
G
V
L
----
V
P
G
P
G
L
V
T
L
L
R
T
LPMF
H
D
K
E
F
A
Q
A
-
Q
G
L
-------
P
D
H
A
L
A
L
---------------------
P
--------------------------
P
ASH
G
P
R
V
L
Y
T
V
----
L
E
C
Q
--
P
L
L
D
S
S
D
M
T
I
D
D
W
I
R
-
I
A
K
I
I
E
R
H
Y
-
E
--
Q
Y
Q
G
F
V
V
I
H
G
A
D
T
M
A
S
G
A
S
M
L
S
--
F
M
L
E
-
N
-
L
H
K
P
V
I
L
T
G
A
Q
V
P
I
R
V
L
-------
W
N
D
A
R
E
N
L
L
G
A
L
-----
L
---
V
A
G
Q
Y
IIPEV
C
L
F
M
N
S
Q
-------
L
F
R
G
N
R
V
T
K
V
D
S
Q
K
F
E
A
F
C
--------------------
S
P
-
L
-
S
--
P
----
L
--------
A
--
T
--
V
----
G
----
A
D
V
---
T
----
I
----
A
W
D
--
L
V
R
K
V
---
K
W
KD
P
L
V
V
H
SN
M
E
H
D
V
A
L
-------
L
R
L
Y
PGIP-----
A
S
L
V
-----
R
A
F
L
Q
P
P
L
K
G
V
V
L
E
T
F
G
S
G
N
G
P
S
-
K
P
D
L
L
Q
E
L
R
A
A
A
Q
R
G
L
I
M
V
-
N
C
S
Q
C
L
R
G
S
V
-
T
-
P
-
G
Y
A
T
S
L
A
G
--
A
N
I
V
-----
S
G
L
D
M
T
S
E
A
A
L
A
K
L
S
Y
V
L
G
L
P
E
L
S
L
E
R
R
Q
E
L
L
-
3
PsiBlast_PDB
75.54
25%
-97
- C2 -
-
2P2N
7
ASPG1_ECOLI
A:
[24-331]
-
K
S
I
Y
V
A
Y
T
G
G
T
I
G
--
M
----------------------------------------------
E
F
H
R
P
E
---------------------
M
--------------------------
P
-----
D
F
T
I
H
E
----
Y
T
P
----
L
M
D
S
S
D
M
T
P
E
D
W
Q
H
I
A
E
D
I
K
A
-
H
Y
-
D
--
D
Y
D
G
F
V
I
L
H
G
T
D
T
M
A
Y
T
A
S
A
L
S
-
F
M
L
E
N
L
G
-
K
P
--
V
I
V
T
G
S
Q
I
P
L
A
E
L
R
S
D
G
Q
I
N
L
L
N
A
---
L
Y
V
A
A
N
Y
P
I
N
E
---
V
T
---------
L
F
F
N
N
R
-------
L
Y
R
G
N
R
T
T
K
A
H
A
D
G
F
D
A
F
A
--------------------
S
P
N
L
-
P
--
P
----
L
--------
L
--
E
--
A
----
G
----
I
H
I
---
R
----
R
L
NTP
P
A
P
--
H
-
G
E
G
---
E
L
---------
I
V
H
P
I
T
P
-------
Q
P
I
G
V
V
T
I
Y
PGIS
A
D
V
V
-----
R
N
F
L
R
Q
P
V
K
A
L
I
L
R
S
Y
G
V
G
N
A
P
Q
-
N
K
A
F
L
Q
E
L
Q
E
A
S
D
R
G
I
V
V
V
-
N
L
T
Q
C
M
S
G
K
V
----------
N
A
L
A
H
A
G
V
I
-----
G
G
A
D
M
T
V
E
A
T
L
T
K
L
H
Y
-----------------
40
HHSearch
74.92
25%
-48
- C2 -
-
4R8K
2
?
C:
[31-378]
E
R
H
L
L
L
I
Y
T
G
G
T
L
G
--
M
Q
-
S
K
G
G
----
V
L
V
P
------------
G
P
-------
G
L
V
-------
T
-
L
L
R
T
L
---------------------
P
MFHD
K
E
F
A
Q
A
Q
GLPDH
A
L
A
L
P
PASHG
P
-----
R
V
L
Y
T
V
----
L
E
C
Q
--
P
L
L
D
S
S
D
M
T
I
D
D
W
I
R
I
A
K
I
I
E
R
-
H
Y
-
E
--
Q
Y
Q
G
F
V
V
I
H
G
T
D
T
M
A
S
G
A
S
M
L
S
-
F
M
L
E
N
L
H
-
K
P
--
V
I
L
T
G
A
Q
V
P
I
R
V
L
W
N
-------
D
A
R
E
N
L
L
G
A
L
L
V
A
G
Q
Y
I--
I
P
E
V
C
------
L
F
M
N
S
Q
-------
L
F
R
G
N
R
V
T
K
V
D
S
Q
K
F
E
A
F
C
-----------
S
P
N
-
L
S
P
L
A
T
V
G
A
-
D
--
V
----
T
I
AWD----
L
V
R
K
V
K
W
----
K
----
D
P
L
V
V
-
H
----
S
----
N
M
E
--
H
-
D
V
A
---
L
L
---------
R
L
Y
P
G
I
P
-------
A
S
L
-------------
V
-----
R
A
F
L
Q
P
P
L
K
G
V
V
L
E
T
F
G
S
G
N
G
P
S
-
K
P
D
L
L
Q
E
L
R
A
A
A
Q
R
G
L
I
M
V
-
N
C
S
Q
C
L
R
G
S
V
-
T
-
P
-
G
Y
A
T
--
S
L
A
G
A
N
I
V
S
G
L
D
M
T
S
E
A
A
L
A
K
L
S
Y
V
L
G
L
P
E-
L
S
L
E
R
R
Q
E
L
L
A
K
D
L
R
5
PsiBlast_PDB
74.85
26%
0
- C- -
-
2OCD
-
?
A:
[4-284]
-
K
H
I
Y
I
A
Y
T
G
G
T
I
G
--
M
K
-
K
S
D
--------
P
------------
V
A
-------
G
F
M
E
K
Q
L
ASM
P
E
F
H
R
P
E
---------------------
M
--------------------------
P
-----
L
F
T
I
H
E
----
Y
D
P
----
L
M
D
S
S
D
M
T
P
A
D
W
-
Q
L
I
A
D
D
I
A
A
N
Y
-
D
--
K
Y
D
G
F
V
I
L
H
G
T
D
T
M
A
Y
T
A
S
A
L
S
F
M
F
E
N
L
-
G
-
K
P
--
V
I
V
T
G
S
Q
I
P
L
A
D
L
R
S
D
G
Q
A
N
L
L
N
A
---
L
H
V
A
A
N
Y
P
I
N
E
---
V
T
---------
L
F
F
N
N
R
-------
L
M
R
G
N
R
S
R
K
S
H
A
D
G
F
S
A
F
S
-----------
S
P
N
-
L
P
P
L
L
E
A
G
I
-
N
--
I
----
E
--------
L
--
S
--
T
----
N
----
V
K
V
---
D
----
E
----
K
P
S
G
E
F
-
K
V
N
---
P
I
---------
T
P
Q
P
I
G
V
I
T
M
Y
PGI
S
H
E
----------
V
--
I
-----
R
N
T
L
L
Q
P
V
N
A
M
I
L
L
T
F
G
V
G
N
A
P
Q
-
N
P
E
L
L
A
Q
L
K
A
A
S
E
R
G
V
I
V
V
-
N
L
T
Q
C
L
A
G
K
V
-
N
-------------------------------------------------------
13
PsiBlast_PDB
73.34
26%
-60
- C2 -
-
5DNE
5
?
A:
[32-373]
-
R
H
L
L
L
I
Y
T
G
G
T
L
G
M
Q
S
K
-
G
G
V
L
----
V
P
G
P
G
L
V
T
L
L
R
T
LPMF
H
D
K
E
F
A
Q
A
-
Q
G
L
-------
P
D
H
A
L
A
L
---------------------
P
--------------------------
P
ASH
G
P
R
V
L
Y
T
V
----
L
E
C
Q
--
P
L
L
D
S
S
D
M
T
I
D
D
W
I
R
-
I
A
K
I
I
E
R
H
Y
-
E
--
Q
Y
Q
G
F
V
V
I
H
G
T
D
T
M
A
S
G
A
S
M
L
S
--
F
M
L
E
-
N
-
L
H
K
P
V
I
L
T
G
A
Q
V
P
I
R
V
L
-------
W
N
D
A
R
E
N
L
L
G
A
L
-----
L
---
V
A
G
Q
Y
IIPEV
C
L
F
M
N
S
Q
-------
L
F
R
G
N
R
V
T
M
V
D
S
Q
K
F
E
A
F
C
--------------------
S
P
N
L
-
S
--
P
----
L
--------
A
--
T
--
V
----
G
----
A
D
V
---
T
----
I
----
A
W
D
--
L
V
R
K
V
---
K
W
KD
P
L
V
V
H
SN
M
E
H
D
V
A
L
-------
L
R
L
Y
P
GIP-----
A
S
L
V
-----
R
A
F
L
Q
P
P
L
K
G
V
V
L
E
T
F
G
S
G
N
G
P
S
-
K
P
D
L
L
Q
E
L
R
A
A
A
Q
R
G
L
I
M
V
-
N
C
S
Q
C
L
R
G
S
V
-
T
-
P
-
G
Y
A
T
S
L
A
G
--
A
N
I
V
-----
S
G
L
D
M
T
S
E
A
A
L
A
K
L
S
Y
V
L
G
L
P
E
L
S
L
E
R
R
Q
E
L
L
-
7
PsiBlast_PDB
70.21
26%
-64
- C2 -
-
4R8K
2
?
A:
[32-334]
-
R
H
L
L
L
I
Y
T
G
G
T
L
G
M
Q
S
K
-
G
G
V
L
----
V
P
G
P
G
L
V
T
L
L
R
T
LPMF
H
D
K
E
F
A
Q
A
-
Q
G
L
-------
P
D
H
A
L
A
L
---------------------
P
--------------------------
P
ASHG
P
R
V
L
Y
T
V
----
L
E
C
Q
--
P
L
L
D
S
S
D
M
T
I
D
D
W
I
R
-
I
A
K
I
I
E
R
H
Y
-
E
--
Q
Y
Q
G
F
V
V
I
H
G
T
D
T
M
A
S
G
A
S
M
L
S
--
F
M
L
E
-
N
-
L
H
K
P
V
I
L
T
G
A
Q
V
P
I
R
V
L
-------
W
N
D
A
R
E
N
L
L
G
A
L
-----
L
---
V
A
G
Q
Y
IIPEV
C
L
F
M
N
S
Q
-------
L
F
R
G
N
R
V
T
K
V
D
S
Q
K
F
E
A
F
C
--------------------
S
P
N
L
-
S
--
P
----
L
--------
A
--
T
--
V
----
G
----
A
D
V
---
T
----
I
----
A
W
D
--
L
V
R
K
V
---
K
W
KD
P
L
V
V
H
SN
M
E
H
D
V
A
L
-------
L
R
L
Y
PGIP-----
A
S
L
V
-----
R
A
F
L
Q
P
P
L
K
G
V
V
L
E
T
F
G
S
G
N
G
P
S
-
K
P
D
L
L
Q
E
L
R
A
A
A
Q
R
G
L
I
M
V
-
N
C
S
Q
C
L
R
G
S
V
-
T
-
P
-
G
Y
A
T
S
-----------------------------------------------
8
PsiBlast_PDB
69.67
26%
-64
- C2 -
-
4R8L
2
?
A:
[32-334]
-
R
H
L
L
L
I
Y
T
G
G
T
L
G
M
Q
S
K
-
G
G
V
L
----
V
P
G
P
G
L
V
T
L
L
R
T
LPMF
H
D
K
E
F
A
Q
A
-
Q
G
L
-------
P
D
H
A
L
A
L
---------------------
P
--------------------------
P
ASH
G
P
R
V
L
Y
T
V
----
L
E
C
Q
--
P
L
L
D
S
S
D
M
T
I
D
D
W
I
R
-
I
A
K
I
I
E
R
H
Y
-
E
--
Q
Y
Q
G
F
V
V
I
H
G
T
D
T
M
A
S
G
A
S
M
L
S
--
F
M
L
E
-
N
-
L
H
K
P
V
I
L
T
G
A
Q
V
P
I
R
V
L
-------
W
N
D
A
R
E
N
L
L
G
A
L
-----
L
---
V
A
G
Q
Y
IIPEV
C
L
F
M
N
S
Q
-------
L
F
R
G
N
R
V
T
K
V
D
S
Q
K
F
E
A
F
C
--------------------
S
P
N
L
-
S
--
P
----
L
--------
A
--
T
--
V
----
G
----
A
D
V
---
T
----
I
----
A
W
D
--
L
V
R
K
V
---
K
W
KD
P
L
V
V
H
SN
M
E
H
D
V
A
L
-------
L
R
L
Y
PGIP-----
A
S
L
V
-----
R
A
F
L
Q
P
P
L
K
G
V
V
L
E
T
F
G
S
G
N
G
P
S
-
K
P
D
L
L
Q
E
L
R
A
A
A
Q
R
G
L
I
M
V
-
N
C
S
Q
C
L
R
G
S
V
-
T
-
P
-
G
Y
A
T
S
-----------------------------------------------
2
PsiBlast_PDB
68.80
25%
-38
- C2 -
-
2P2D
3
ASPG1_ECOLI
A:
[24-331]
-
K
S
I
Y
V
A
Y
T
G
G
T
I
G
--
M
Q
-
R
S
E
Q
----
G
Y
I
P
------------
V
S
G
H
L
Q
R
Q
L
A
L
M
-------
P
E
F
H
R
P
E
---------------------
M
--------------------------
P
-----
D
F
T
I
H
E
----
Y
T
P
----
L
M
D
S
S
D
M
T
P
E
D
W
Q
H
I
A
E
D
I
K
A
-
H
Y
-
D
--
D
Y
D
G
F
V
I
L
H
G
T
D
T
M
A
Y
T
A
S
A
L
S
-
F
M
L
E
N
L
G
-
K
P
--
V
I
V
T
G
S
Q
I
P
L
A
E
L
R
S
D
G
Q
I
N
L
L
N
A
---
L
Y
V
A
A
N
Y
P
I
N
E
---
V
T
---------
L
F
F
N
N
R
-------
L
Y
R
G
N
R
T
T
K
A
H
A
D
G
F
D
A
F
A
--------------------
S
P
N
L
-
P
--
P
----
L
--------
L
--
E
--
A
----
G
----
I
H
I
---
R
----
R
L
NTP
P
A
P
--
H
-
G
E
G
---
E
L
---------
I
V
H
P
I
T
P
-------
Q
P
I
G
V
V
T
I
Y
PGIS
A
D
V
V
-----
R
N
F
L
R
Q
P
V
K
A
L
I
L
R
S
Y
G
V
G
N
A
P
Q
-
N
K
A
F
L
Q
E
L
Q
E
A
S
D
R
G
I
V
V
V
-
N
L
T
Q
C
M
S
G
K
V
-
N
-
M
------
N
A
L
A
H
A
G
V
I
-----
G
G
A
D
M
T
V
E
A
T
L
T
K
L
H
Y
-----------------
53
HHSearch
67.55
26%
-54
- C2 -
-
5DNC
7
?
C:
[33-325]
--
H
L
L
L
I
Y
T
G
G
A
L
G
--
M
Q
-
S
K
G
G
----
V
L
V
P
------------
G
P
-------
G
L
V
-------
T
L
L
R
T
L
P
MFHDKEFAQAQGLPDHALALP
P
ASH-----------------------
G
-----
P
R
V
L
Y
T
----
V
-
L
E
CQ
P
L
L
D
S
S
D
M
T
I
D
D
W
I
R
I
A
K
I
I
E
R
-
H
Y
-
E
--
Q
Y
Q
G
F
V
V
I
H
G
T
D
T
M
A
S
G
A
S
M
L
S
-
F
M
L
E
N
L
H
-
K
P
--
V
I
L
T
G
A
Q
V
P
I
R
V
L
W
N
-------
D
A
R
E
N
L
L
G
A
L
L
V
A
G
Q
Y
I--
I
P
E
V
C
------
L
F
M
N
S
Q
-------
L
F
R
G
N
R
V
T
K
V
D
S
Q
K
F
E
A
F
C
-----------
S
P
N
-
L
S
P
L
A
T
V
G
A
-
D
--
V
TIAW
D
LV------
R
--
K
--
V
KW--
K
----
D
P
L
VV-
H
----
S
----
N
M
E
--
H
-
D
V
A
---
L
L
---------
R
L
Y
P
G
I
P
-------
A
S
L
-------------
V
-----
R
A
F
L
Q
P
P
L
K
G
V
V
L
E
T
F
G
S
G
N
G
P
S
-
K
P
D
L
L
Q
E
L
R
A
A
A
Q
R
G
L
I
M
V
-
N
C
S
Q
C
L
R
G
-----------------------------------------------------------
50
HHSearch
67.44
21%
-31
- C2 -
-
3NXK
3
?
C:
[8-333]
K
S
R
I
A
I
L
G
T
G
G
T
I
A
--
G
F
-
I
D
S
T
I
A
T
T
G
Y
A
A
------------
G
A
-------
I
D
I
-------
D
V
L
I
K
A
V
---------------------
P
QIR-----------------------
D
-----
L
A
D
I
S
W
----
E
-
Q
I
--
A
N
I
D
S
S
N
M
C
D
E
I
W
L
R
L
A
K
K
I
A
K
-
L
F
A
E
--
G
I
D
G
V
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
N
-
L
T
I
K
S
-
D
-
K
P
--
V
V
L
V
G
A
M
R
P
S
T
A
I
S
A
-------
D
G
P
K
N
L
Y
N
A
V
A
L
V
V
N
K
E
A
K
N
K
G
V
M
------
V
A
I
N
D
K
-------
I
L
S
A
R
G
V
V
K
T
H
S
L
N
V
D
A
F
S
-----------
S
P
D
-
F
G
D
L
G
Y
I
V
D
-
G
K-
V
----
F
FYNN----
V
--
I
--
K
----
A
HT
K
N
A
P
F
D
V
-
S
K
---
L
----
T
S
L
--
P
-
K
V
D
---
I
L
---------
Y
S
Y
S
N
D
G
S------
G
V
A
-------------
A
-----
K
A
L
F
E
H
G
T
K
G
I
V
V
A
G
S
G
A
G
S
I
H
K
-
N
--
Q
K
D
V
L
K
E
L
L
K
K
G
L
K
V
V
-
V
S
S
R
V
V
A
G
C
V
-
A
-
V
-
S
----
D
S
D
E
K
L
G
F
I
S
A
E
D
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
T
K
T
--
S
D
P
K
K
I
Q
E
Y
F
L
K
---
4
PsiBlast_PDB
67.29
25%
-30
- C2 -
-
2HIM
8
ASPG1_ECOLI
A:
[24-331]
-
K
S
I
Y
V
A
Y
T
G
G
T
I
G
--
M
Q
-
R
---------
I
P
------------
V
S
G
H
L
Q
R
Q
L
A
L
M
-------
P
E
F
H
R
P
E
---------------------
M
--------------------------
P
-----
D
F
T
I
H
E
----
Y
T
P
----
L
M
D
S
S
D
M
T
P
E
D
W
Q
H
I
A
E
D
I
K
A
-
H
Y
-
D
--
D
Y
D
G
F
V
I
L
H
G
T
D
T
M
A
Y
T
A
S
A
L
S
-
F
M
L
E
N
L
G
-
K
P
--
V
I
V
T
G
S
Q
I
P
L
A
E
L
R
S
D
G
Q
I
N
L
L
N
A
---
L
Y
V
A
A
N
Y
P
I
N
E
---
V
T
---------
L
F
F
N
N
R
-------
L
Y
R
G
N
R
T
A
K
A
H
A
D
G
F
D
A
F
A
--------------------
S
P
N
L
-
P
--
P
----
L
--------
L
--
E
--
A
----
G
----
I
H
I
---
R
----
R
L
NTP
P
A
P
--
H
-
G
E
G
---
E
L
---------
I
V
H
P
I
T
P
-------
Q
P
I
G
V
V
T
I
Y
PGIS
A
D
V
V
-----
R
N
F
L
R
Q
P
V
K
A
L
I
L
R
S
Y
G
V
G
N
A
P
Q
-
N
K
A
F
L
Q
E
L
Q
E
A
S
D
R
G
I
V
V
V
-
N
L
T
Q
C
M
S
G
K
V
-
N
-
M
G-----
N
A
L
A
H
A
G
V
I
-----
G
G
A
D
M
T
V
E
A
T
L
T
K
L
H
Y
-----------------
39
HHSearch
66.55
24%
-30
- C2 -
-
2HIM
8
ASPG1_ECOLI
A:
[23-351]
K
K
S
I
Y
V
A
Y
T
G
G
T
I
G
--
M
Q
-
R
---------
I
P
------------
V
S
-------
G
H
L
-------
Q
R
Q
L
A
L
M
---------------------
P
EFHRP---------------------
E
-----
M
P
D
F
T
I
----
H
E
Y
T
--
P
L
M
D
S
S
D
M
T
P
E
D
W
Q
H
I
A
E
D
I
K
A
-
H
Y
-
D
--
D
Y
D
G
F
V
I
L
H
G
T
D
T
M
A
Y
T
A
S
A
L
S
-
F
M
L
E
N
L
G
-
K
P
--
V
I
V
T
G
S
Q
I
P
L
A
E
L
R
S
-------
D
G
Q
I
N
L
L
N
A
L
Y
V
A
A
N
Y
P--
I
N
E
V
T
------
L
F
F
N
N
R
-------
L
Y
R
G
N
R
T
A
K
A
H
A
D
G
F
D
A
F
A
-----------
S
P
N
-
L
P
P
L
L
E
A
G
I
-
H
--
I
----
R
R
L
NT----
P
P-
A
--
P
H
G
--
E
----
G
E
L
I
V
-
H
----
P
----
I
T
P
--
Q
-
P
I
G
---
V
V
---------
T
I
Y
P
G
I
S
-------
A
D
V
-------------
V
-----
R
N
F
L
R
Q
P
V
K
A
L
I
L
R
S
Y
G
V
G
N
A
P
Q
-
N
K
A
F
L
Q
E
L
Q
E
A
S
D
R
G
I
V
V
V
-
N
L
T
Q
C
M
S
G
K
V
N
M
-
G
------
N
A
L
A
H
A
G
V
I
G
G
A
D
M
T
V
E
A
T
L
T
K
L
H
Y
L
L
S
Q
E
--
L
D
T
E
T
I
R
K
A
M
S
Q
N
L
R
38
HHSearch
62.99
24%
-24
- C2 -
-
2OCD
-
?
B:
[3-332]
R
K
H
I
Y
I
A
Y
T
G
G
T
I
G
--
M
K
-
K
S
D
-------
V
P
------------
V
A
-------
G
F
M
-------
E
K
Q
L
A
S
M
---------------------
P
EFHRP---------------------
E
-----
M
P
L
F
T
I
----
H
E
Y
D
--
P
L
M
D
S
S
D
M
T
P
A
D
W
Q
L
I
A
D
D
I
A
A
-
N
Y
-
D
--
K
Y
D
G
F
V
I
L
H
G
T
D
T
M
A
Y
T
A
S
A
L
S
-
F
M
F
E
N
L
G
-
K
P
--
V
I
V
T
G
S
Q
I
P
L
A
D
L
R
S
-------
D
G
Q
A
N
L
L
N
A
L
H
V
A
A
N
Y
P--
I
N
E
V
T
------
L
F
F
N
N
R
-------
L
M
R
G
N
R
S
R
K
S
H
A
D
G
F
S
A
F
S
-----------
S
P
N
-
L
P
P
L
L
E
A
G
I
-
N
--
I
----
E
L
S
T
NVKVD
E
--
K
--
P
----
S
----
G
E
F
K
V
-
N
----
P
----
I
T
P
--
Q
-
P
I
G
---
V
I
---------
T
M
Y
P
G
I
S
-------
H
E
V
-------------
I
-----
R
N
T
L
L
Q
P
V
N
A
M
I
L
L
T
F
G
V
G
N
A
P
Q
-
N
P
E
L
L
A
Q
L
K
A
A
S
E
R
G
V
I
V
V
-
N
L
T
Q
C
L
A
G
K
V
N
M
-
G
-
G
Y
A
T
G
C
A
L
A
D
A
G
V
I
S
G
Y
D
M
T
P
E
A
A
L
A
K
L
H
Y
L
L
S
Q
N
--
L
S
Y
E
E
V
K
A
K
M
Q
Q
V
L
R
37
HHSearch
62.44
18%
-21
- C2 -
-
1ZQ1
2
GATD_PYRAB
A:
[91-424]
L
P
E
V
T
I
I
G
T
G
G
T
I
A
--
S
R
-
I
D
Y
E
TG--
A
V
Y
P
------------
A
F
-------
T
A
--------
E
E
L
A
K
A
L
---------------------
P
E
I
F
-----------------------
E
-----
V
A
N
V
K
P
----
K
-
L
L
--
F
N
I
F
S
E
D
M
K
P
K
H
W
V
K
I
A
H
E
V
A
K
-
A
L
N
S
--
G
D
Y
G
V
V
V
A
H
G
T
D
T
M
G
Y
T
A
A
A
L
S
-
F
M
L
R
N
L
G
-
K
P
--
V
V
L
V
G
A
Q
R
S
S
D
R
P
S
S
-------
D
A
A
M
N
L
I
C
S
V
R
M
A
T
S
E
---
V
A
E
V
M
------
V
V
M
H
G
E
TGD
T
Y
C
L
A
H
R
G
T
K
V
R
K
M
H
T
S
R
R
D
A
F
R
-----------
S
I
N
-
D
V
P
I
A
K
I
W
P
-
N
G
E
I
----
E
F
LRK----
D
Y-
R
--
K
RS--
D
----
E
E
V
E
V
-
D
----
D
----
K
I
E
--
E
-
K
V
A
---
L
V
---------
K
V
Y
P
G
I
S
-------
S
E
I
-------------
I
-----
D
F
L
V
D
K
G
Y
K
G
I
V
I
E
G
T
G
L
G
H
T
P
N
-
D
--
I
I
P
S
I
E
R
A
V
E
E
G
V
A
V
C
-
M
T
S
Q
C
I
Y
G
R
V
N
L
-
N
-
V
Y
S
T
G
R
K
L
L
K
A
G
V
I
P
C
E
D
M
L
P
E
T
A
Y
V
K
L
M
W
V
L
G
H
T
--
Q
N
L
E
E
V
R
K
M
M
L
T
N
Y
A
11
PsiBlast_PDB
60.88
28%
-100
- C2 -
-
1WLS
-
?
A:
[50-285]
---------------------------------------------------------------------------------------------------------------------------------------------
V
D
S
T
L
I
Q
P
S
D
W
E
R
L
A
K
E
I
E
K
E
V
W
-
E
---
Y
D
G
I
V
I
T
H
G
T
D
T
M
A
Y
S
A
S
M
L
S
-
F
M
L
R
N
-
P
P
I
P
--
I
V
L
T
G
S
M
L
P
I
-------
T
E
K
N
S
D
A
P
F
N
L
R
T
A
L
E
F
V
K
L
G
---
I
R
G
I
Y
------
I
A
F
N
G
K
-------
V
M
L
G
V
R
A
S
K
I
R
S
M
G
F
D
A
F
E
-----------
S
I
N
Y
P
N
V
A
E
I
K
D
D
-
K
--
L
----
R
--------
I
--
L
--
H
----
I
----
P
D
F
---
Y
----
G
----
D
E
F
--
F
-
S
D
I
---
K
Y
---------
E
P
K
V
L
V
I
-------
K
-
L
----------
I
P
G
L
SG
D
I
V
R
E
A
L
R
L
G
Y
K
G
I
I
L
E
G
Y
G
V
G
G
I
P
Y
-
R
G
T
D
L
F
E
V
V
S
S
I
S
K
R
I
P
V
V
-
L
T
T
Q
A
I
Y
D
G
V
-
D
L
Q
-
R
Y
K
V
G
R
I
A
L
E
A
G
V
I
--------------------------------------
42
HHSearch
59.94
22%
-22
- C2 -
-
2WLT
1
ASPG_HELPJ
A:
[5-331]
L
P
T
I
A
L
L
A
T
G
G
T
I
A
--
G
S
-
G
--
A
SL
G
-
S
Y
K
S
------------
G
E
-------
L
G
V
-------
K
E
L
L
K
A
I
---------------------
P
SLN-----------------------
K
-----
I
A
R
I
Q
G
----
E
-
Q
V
--
S
N
I
G
S
Q
D
M
N
E
E
I
W
F
K
L
A
Q
R
A
Q
E
-
L
L
-
D
DS
R
I
Q
G
V
V
I
T
H
G
T
D
T
L
E
E
S
A
Y
F
L
N
-
L
V
L
H
S
-
T
-
K
P
--
V
V
L
V
G
A
M
R
N
A
S
S
L
S
A
-------
D
G
A
L
N
L
Y
E
A
V
S
V
A
V
N
E
KSA
N
K
G
V
L
------
V
V
M
D
D
T
-------
I
F
S
V
R
E
V
V
K
T
H
T
T
H
V
S
T
F
K
-----------
A
L
N
-
S
G
A
I
G
S
V
Y
Y
-
G
K
-
T
----
R
Y
YMQ----
P
--
L
--
R
----
K
HTTE
S
E
F
---
S
LSQL
K
----
T
P
L
--
P
-
K
V
D
---
I
I
---------
Y
T
H
A
G
M
T
-------
P
D
L
-------------
F
-----
Q
A
S
L
N
S
H
A
K
G
V
V
I
A
G
V
G
N
G
N
V
S
A
-
G
--
F
L
K
A
M
Q
E
A
S
Q
M
G
V
V
I
V
-
R
S
S
R
V
G
S
G
G
V
T
S
-
G
-
E
I
D
----
D
K
A
Y
G
F
I
T
S
D
N
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
K
T
--
N
D
K
A
K
I
Q
E
M
F
E
E
---
6
PsiBlast_PDB
58.72
28%
-95
- C2 -
-
1WNF
2
?
A:
[50-285]
---------------------------------------------------------------------------------------------------------------------------------------------
V
D
S
T
L
I
Q
P
S
D
W
E
R
L
A
K
E
I
E
K
E
V
W
-
E
---
Y
D
G
I
V
I
T
H
G
T
D
T
M
A
Y
S
A
S
M
L
S
-
F
M
L
R
N
-
P
P
I
P
--
I
V
L
T
G
S
M
L
P
I
-------
T
E
K
N
S
D
A
P
F
N
L
R
T
A
L
E
F
V
K
L
G
---
I
R
G
I
Y
------
I
A
F
N
G
K
-------
V
M
L
G
V
R
A
S
K
I
R
S
M
G
F
D
A
F
E
-----------
S
I
N
Y
P
N
V
A
E
I
K
D
D
-
K
--
L
----
R
--------
I
--
L
--
H
----
I
----
P
D
F
---
Y
----
G
----
D
E
F
--
F
-
S
D
I
---
K
Y
---------
E
P
K
V
L
V
I
-------
K
-
L
----------
I
P
G
L
SG
D
I
V
R
E
A
L
R
L
G
Y
K
G
I
I
L
E
G
Y
G
V
G
G
I
P
Y
-
R
G
T
D
L
F
E
V
V
S
S
I
S
K
R
I
P
V
V
-
L
T
T
Q
A
I
Y
D
G
V
-
D
L
Q
-
R
Y
K
V
G
R
I
A
L
E
A
G
V
I
--------------------------------------
9
PsiBlast_PDB
58.59
27%
-15
- C2 -
-
4Q0M
4
?
A:
[1-286]
M
M
K
I
L
L
I
G
M
G
G
T
I
A
--
S
V
K
G
E
N
--------
G
------------
Y
E
-------
A
S
L
--------
S
V
K
E
V
L
---------------------
D
--------------------------
I
-----
A
G
I
K
D
C
ED
C
D
F
L
D
L
--
K
N
V
D
S
T
L
I
Q
P
E
D
W
V
D
L
A
E
T
L
Y
K
-
N
V
-
K
--
K
Y
D
G
I
I
V
T
H
G
T
D
T
L
A
Y
T
S
S
M
I
S
-
F
M
L
R
N
-
P
P
I
P
--
I
V
F
T
G
S
M
I
P
A
-------
T
E
E
N
S
D
A
P
L
N
L
Q
T
A
I
K
F
A
T
S
G
---
I
R
G
V
Y
------
V
A
F
N
G
K
-------
V
M
L
G
V
R
T
S
K
V
R
T
M
S
R
D
A
F
E
SINYPIIAELR
G
E
D
-
L
V
V
N
F
I
P
K
F
-
N
NG
E
----
V
--------
T
--
L
--
D
----
L
----
R
H
D
---
P
----
K
----
V
L
V
--
I
-
K
L
I
---
P
G
---------
L
S
G
D
I
-------------------------
F
-----
R
A
A
V
E
L
G
Y
R
G
I
V
I
E
G
Y
G
A
G
G
I
P
Y
R
G
S
D
L
L
Q
T
I
E
E
L
S
K
E
--
I
P
I
V
M
T
T
Q
A
M
Y
D
G
V
-
D
L
T
-
R
Y
K
V
G
R
L
A
L
R
A
G
V
I
--------------------------------------
43
HHSearch
57.60
18%
-13
- C2 -
-
1HO3
1
ASPG2_ECOLI
B:
[1-325]
L
P
N
I
T
I
L
A
T
G
G
T
I
A
--
G
G
-
G
D
S
A
TKS-
N
F
T
V
------------
G
K
-------
V
G
V
-------
E
N
L
V
N
A
V
PQL------------------
K
--------------------------
D
-----
I
A
N
V
K
G
----
E
-
Q
V
--
V
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
-
D
C
-
D
--
K
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
-
L
T
V
K
C
-
D
-
K
P
--
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
-------
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
ASA
N
R
G
V
L
------
V
V
M
N
D
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
-----------
S
V
N
-
Y
G
P
L
G
Y
I
H
N
G
K
--
I
----
D
YQRT----
P
--
A
--
R
KHTS
D
----
T
P
F
DVS
K
----
L
----
N
E
L
--
P
-
K
V
G
---
I
V
---------
Y
N
Y
A
N
A
S
-------
D
L
P
-------------
A
-----
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
-
S
--
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
-
R
S
S
R
V
P
T
G
A
T
-
T
-
Q
-
D
A
--
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
Q
T
--
K
D
P
Q
Q
I
Q
Q
I
F
N
Q
---