@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLD0: (2017-11-01 )
MTSLNSSYGRSQAVPLSVFEQSKDAHIIRSDEEAIEIAKQLAQEFATEASDRDRERRLPLNEIQQFSQSGLWAITVPKQFGGAQVKYRTLAEVIKTIASVDSSLAQLPQNHLAFIEHLRLDAKPEQQQFFFNLVLRGIRFGNAFSEKHSKTVADLTTTLRKTEHGYEINGKKFFATGALLAHWIPIVAVNELGQPYAALVPRETSGVNIINDWSGFGQRTTASGTVELNQVPVREEYLVPIYQAFESPTPAGAISQFIQAAVDAGIARGAIEETIQYVKNHSRAWIDSGLEKASDDPYTIANIGDLKIKLRAAEAVLDLAGDAIDQAIANTTEEHVNQATLLVAEAKVLTTEIAILAANKLFELSGTRSTLSELNLDRHWRNARTHTLHDPVRWKYHIVGNYYLNGVQPPRHAWS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80.-.......90........100.......110.......120----........130......-.140........150.......160....-....170.......180......--.190-----...-----.---..--.200.......210.......220......--.230.-.....-----------------.---240...-------..-..------250.......260.......270.......280.......290.......300.......310.-----------......320.......330---.......340-----......---..350.......360.......370.......380.---......390.......400.......410...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTSLNSSYGRSQAV
P
L
S
V
FEQSKD
A
H
I
IRS
D
E
E
A
I
E
I
A
K
Q
L
A
Q
E
F
A
T
EASD
R
D
R
ERRL
P
L
N
E
I
Q
Q
F
S
QSG
L
W
A
I
TVPKQFGG-
A
Q
V
K
Y
R
T
L
A
E
V
I
K
T
I
A
S
V
D
S
S
L
A
QL
P
Q
N
H
L
A
F
I
E
H
LRLD-----AK
P
E
Q
Q
Q
F
F
F
N
L
V
L
R
G
I-RF-G
N
A
F
S
E
K
HS
K
T
V
A
D
L
T
T
T
L
R
K-TEHG-
Y
E
ING
K
K
F
F
A
T
G
A
L
L
A
H
W
I
P
I
V
A
--
V
N
EL-----GQ
P
-----
Y
---
A
A
--LVPRETSG
V
N
I
INDWSGFGQRTTAS
G
T
V
E
L--NQVPV-
R
E
E
Y
L
-----------------
V
---
P
I
Y
Q
A
F-------ES-PT------P
A
G
A
I
S
Q
F
I
Q
A
A
V
D
AGIA
R
G
A
I
E
E
T
I
Q
Y
V
K
NH
S
R
A
W
I
D
S
G
L
E
KASDDP
Y
T
I
A
NI
G
D
L
K
I
K
L
R
A
A
-----------
E
A
V
L
D
L
A
G
D
A
I
D
Q
A
I
A
N
T
T
---
E
E
H
V
NQ
A
T
L
------
L
V
A
E
A
K
---
V
L
T
T
E
I
A
I
L
A
AN
K
L
F
ELSG
T
R
S
T
L
S
EL
N
L
D
R
H
WRNA---RTHTLHDP
V
R
W
K
Y
H
I
V
G
N
Y
Y
LNGVQPPRHAWS
10
PsiBlast_PDB
88.27
26%
0
- C- -
-
3AFE
-
HSAA_MYCTU
A:
[7-391]
----------------------------
R
D
A
Q
S
V
L
A
A
I
D
N
L
L
P
E
I
R
D
R
A
Q
A
T
E
D
L
R
R
L
P
D
E
T
V
K
A
L
D
D
V
G
F
F
T
L
L
Q
P
Q
Q
W
G
G
-
L
Q
C
D
P
A
L
F
F
E
A
T
R
R
L
A
S
V
C
G
S
T
G
W
V
S
S
I
V
G
V
H
N
W
H
L
A
L
F
-----
D
Q
R
A
Q
E
E
V
-----------
W
-
G
E
D
P
S
T
R
I
S
S
S
Y
A
P
M
G
A
G
V
-
V
-
V
D
G
G
-
Y
L
V
N
G
S
W
N
W
S
S
G
C
D
H
A
S
W
T
F
V
G
G
P
-
V
I
K
D
-----
G
R
P
-----
V
D
F
G
S
F
--
L
I
P
R
--
S
E
Y
E
I
K
D
V
W
Y
V
V
G
L
R
G
T
G
S
N
T
L
V
V
--
K
D
V
F
V
P
R
H
R
F
L
S
Y
K
A
M
N
D
HTA
G
G
L
A
T
N
S
A
---
P
V
Y
K
-------------
M
------
P
W
G
T
M
H
P
T
T
I
S
A
P
I
V
G
M
A
Y
G
A
Y
A
A
H
V
E
H
Q
G
K
R
V
R
A
A
F
A
G
----
A
K
D
D
P
F
A
---------
K
V
R
I
A
-----------
E
A
A
S
D
I
D
A
-
A
W
R
Q
L
I
G
N
V
S
---
D
E
Y
A
L
L
A
A
G
K
E
I
P
F
E
L
R
A
R
A
R
R
D
Q
V
R
A
T
G
R
S
I
A
S
I
D
R
L
F
E
A
S
G
A
T
A
L
S
N
E
A
P
I
Q
R
F
W
R
D
A
H
A
G
R
V
H
A
A
N
D
P
E
R
-
A
Y
V
I
F
G
N
H
E
F
-
G
L
P
P
------
2
PsiBlast_PDB
85.65
31%
-
- C2 -
-
4NXL
-
?
A:
[19-411]
--------------------------------
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
S
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQG
A
I
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
V
L
A
F
I
Q
S
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
D
A
A
A
R
E
A
A
H
L
L
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
1
PsiBlast_PDB
83.46
31%
-14
- C2 -
-
4JEK
-
SOXC_RHOSG
A:
[19-411]
--------------------------------
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
S
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQG
A
I
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
V
L
A
F
I
Q
S
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
D
A
A
A
R
E
A
A
H
L
L
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
62
HHSearch
83.38
31%
-9
- C2 -
-
4DOY
3
?
B:
[38-434]
-------------------------------
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
W
W
T
-
G
N
A
S
S
E
N
N
-
S
H
V
L
D
W
K
V
S
A
T
P
T
E
D
G
G
-
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
DSPQQ
G
A
I
-----
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
-------
V
L
A
F
I
QSERGS
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
-----------
D
A
A
A
R
E
A
A
H
L
L
Q
T
V
W
D
K
G
D
ALT
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
I
P
G
---
21
PsiBlast_CBE
82.97
31%
-15
- C2 -
-
4DOY
3
?
H:
[38-431]
-------------------------------
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
S
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQGAI
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
VLAFIQS
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
DAAAREAAHLL
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
22
PsiBlast_CBE
82.46
31%
-14
- C2 -
-
4DOY
3
?
G:
[38-431]
-------------------------------
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
S
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQGAI
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
VLAFIQS
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
DAAAREAAHLL
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
24
PsiBlast_CBE
82.40
31%
-11
- C2 -
-
4DOY
3
?
E:
[38-431]
-------------------------------
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
S
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQGAI
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
VLAFIQS
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
DAAAREAAHLL
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
32
PsiBlast_CBE
82.05
31%
-12
- C2 -
-
3X0Y
1
?
B:
[18-411]
-------------------------------
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
R
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQG
A
I
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
V
L
A
F
I
Q
S
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
D
A
A
A
R
E
A
A
H
L
L
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
27
PsiBlast_CBE
81.91
31%
-13
- C2 -
-
4DOY
3
?
B:
[38-431]
-------------------------------
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
S
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQGAI
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
VLAFIQS
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
DAAAREAAHLL
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
5
PsiBlast_PDB
81.91
31%
-10
- C2 -
-
3X0Y
2
?
A:
[16-411]
-----------------------------
A
D
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
R
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQG
A
I
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
V
L
A
F
I
Q
S
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
D
A
A
A
R
E
A
A
H
L
L
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
3
PsiBlast_PDB
81.81
31%
-9
- C2 -
-
4DOY
1
?
A:
[38-431]
-------------------------------
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
S
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQG
A
I
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
V
L
A
F
I
Q
S
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
D
A
A
A
R
E
A
A
H
L
L
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
4
PsiBlast_PDB
81.53
31%
-12
- C2 -
-
3X0X
-
?
A:
[18-411]
-------------------------------
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
R
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQG
A
I
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
V
L
A
F
I
Q
S
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
D
A
A
A
R
E
A
A
H
L
L
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
30
PsiBlast_CBE
81.44
31%
-11
- C2 -
-
3X0Y
1
?
D:
[16-411]
-----------------------------
A
D
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
R
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQGAI
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
VLAFIQS
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
DAAAREAAHLL
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
31
PsiBlast_CBE
81.39
31%
-10
- C2 -
-
3X0Y
1
?
C:
[18-411]
-------------------------------
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
R
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQGAI
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
VLAFIQS
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
DAAAREAAHLL
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
25
PsiBlast_CBE
81.39
31%
-10
- C2 -
-
4DOY
2
?
D:
[38-431]
-------------------------------
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
S
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQGAI
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
VLAFIQS
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
DAAAREAAHLL
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
28
PsiBlast_CBE
81.30
31%
-8
- C2 -
-
3X0Y
2
?
F:
[18-411]
-------------------------------
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
R
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQGAI
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
VLAFIQS
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
DAAAREAAHLL
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
26
PsiBlast_CBE
81.04
31%
-9
- C2 -
-
4DOY
1
?
C:
[38-431]
-------------------------------
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
S
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQGAI
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
VLAFIQS
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
DAAAREAAHLL
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
29
PsiBlast_CBE
80.47
31%
-7
- C2 -
-
3X0Y
1
?
E:
[17-411]
------------------------------
D
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
R
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQGAI
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
VLAFIQS
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
DAAAREAAHLL
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
23
PsiBlast_CBE
80.16
31%
-9
- C2 -
-
4DOY
1
?
F:
[38-431]
-------------------------------
N
D
P
V
A
V
A
R
G
L
A
E
K
W
R
A
T
A
V
E
R
D
R
A
G
G
S
A
T
A
E
R
E
D
L
R
A
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
-
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
-----
G
S
Q
E
Q
E
E
H
L
Y
T
Q
I
A
Q
N
N
-
W
W
T
G
N
A
S
S
E
N
N
S
H
-
V
L
D
W
K
V
S
A
T
P
-
T
E
D
G
G
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
G
--
V
V
Q
D
-----
D
S
P
QQGAI
I
---
A
A
--
A
I
P
T
S
R
A
G
V
T
P
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
--
H
N
V
K
V
-
E
P
D
E
V
-----------------
L
---
G
A
P
N
A
F
VLAFIQS
E
R
-
G
S
------
L
F
A
P
I
A
Q
L
I
F
A
N
V
Y
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
DAAAREAAHLL
Q
T
V
W
D
-
K
G
D
A
L
-------
T
---
P
E
D
R
G
E
L
M
V
------
K
V
S
G
V
K
---
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
P
V
S
Y
K
I
A
D
V
G
K
H
T
L
N
G
Q
Y
P
------
17
PsiBlast_PDB
71.97
22%
-15
- C2 -
-
3MXL
-
?
A:
[17-380]
----------------------------------
V
D
L
L
A
G
V
I
P
R
I
S
A
E
A
A
D
R
D
R
T
G
T
F
P
V
E
A
F
E
Q
F
A
K
L
G
L
M
G
A
T
V
P
A
E
L
G
G
L
G
L
T
R
L
Y
D
V
A
T
A
L
M
R
L
A
E
A
D
A
S
T
A
L
--
A
W
H
V
Q
L
S
R
G
L
T
L
T
Y
E
W
Q
H
G
T
P
P
V
R
A
M
A
E
R
L
-
L
R
A
M
-
A
E
-
G
E
A
A
V
C
G
A
L
K
D
A
P
G
V
V
T
E
L
H
S
D
G
A
G
G
-
W
L
L
S
G
R
K
V
L
V
S
M
A
P
I
A
T
H
F
F
V
H
A
Q
R
R
D
D
D
-----
G
S
V
-----
F
---
L
A
V
P
V
V
H
R
D
A
P
G
L
T
V
L
D
N
W
D
G
L
G
M
R
--
A
S
G
T
L
E
V
V
F
D
R
C
P
V
-
R
A
D
E
L
-----------------
L
ERG
P
V
G
A
R
R
-------
D
A
-
V
L
------
A
G
Q
T
V
S
S
I
T
M
L
G
I
Y
A
G
I
A
Q
A
A
R
D
I
A
V
G
F
C
A
G
R
-------
G
G
E
P
R
A
G
A
R
A
L
V
A
G
L
D
T
R
L
Y
A
L
R
T
T
-----------
V
G
A
A
L
T
N
A
D
A
A
S
V
D
L
S
G
D
P
---
D
E
R
G
R
R
M
M
T
------
P
F
Q
Y
A
K
---
M
T
V
N
E
L
A
P
A
V
V
D
D
C
L
S
L
V
G
G
L
A
Y
T
A
G
H
P
L
S
R
L
Y
R
D
V
---
R
A
G
G
F
M
Q
P
Y
S
Y
---------------------