@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLE0: (2017-11-02 )
MSFEQKPKVTVILANLGTPDEATVPAVRRFLKQFLSDPRVIEIPKFIWWIILNLFVLPFRPKRAAHAYASVWSTDSPMREIVFEQTQRVQAYLERENKQFDLTVLPAMTYGNLGIDAVLEKLSAHPQEHVILLPLFPQYSATSTAPLYDAFAKWIPTQRNLPGLTIIKDYYQHPMFIQALAESVLAYQEQHGKPEKLLMSFHGIPQPYADKGDPYADRCRITAKLVAEALHLKDDEWAISFQSRFGKQEWVKPYTDQLLQDWAKQGVKSVQVLSPAFSADCLETLEELAIQNAELFQQAGGGSYAYIPALNSDQAHIDLLAGLVQANLDALTHTLAHR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70.---.......80........90........-100....-----...110.......120.......130.......140.......150.......--160.--.--.....170.......180.......----190---.....-----...200.......210.......220.......230.......240....-.-..250.......260..-.....270.......280.......290-..-.....300-.......310.......320.......330-........---------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSFEQKP
K
V
T
V
I
L
ANLGTPDEA
T
V
P
A
V
R
R
F
L
K
Q
F
LSDP
R
V
I
E
I
P
K
F
I
W
W
I
I
L
N
L
F
VLPFRPK
R
A
A
H
A
Y
A
SVW---STD
S
P
M
R
E
I
V
F
E
Q
T
Q
R
V
Q
A
Y
L
E
RENK
Q
-
F
D
L
T
V
L
P-----
A
M
TYGNL
G
I
D
A
V
L
E
K
L
SAHPQE
H
V
I
L
L
PLFPQYSATST
A
P
L
Y
D
A
F
A
K
WIPTQR--NLPG--
L
--
T
I
I
K
D
Y
YQH
P
M
F
I
Q
A
L
A
E
S
V
L
A
Y
Q
E
----QH----G
K
P
E
K
-----
L
L
M
S
F
HGIPQPYADKGD
P
Y
A
D
R
C
R
I
T
A
K
L
V
A
E
A
L
HLKDD
E
W
A
I
S
F
Q
S
RFG-
K
-
Q
E
WV
K
P
Y
T
D
Q
L
L
Q
D
W
A
K-Q
G
V
K
S
V
Q
V
LSPAF
S
A
D
C
L
E
T
L
E
E
L
A
I
Q
N
-
A
E
-
L
F
Q
QAGGG-
S
Y
A
Y
I
PALNSD
Q
A
H
I
D
L
L
A
G
L
V
Q
A
N
L
D
A
---
L
T
H
T
LAHR---------------------
42
Fugue
76.93
22%
-27
- C3 -
-
1HRK
4
HEMH_HUMAN
A:
[1-359]
----
R
K
P
K
T
G
I
L
M
L
N
M
G
G
P
E
--
T
L
G
D
V
H
D
F
L
L
R
L
F
L
D
R
D
L
M
T
L
P
---
I
Q
N
K
L
A
P
F
I
A
K
R
L
T
P
K
I
Q
E
Q
Y
R
R
I
G
---
G
G
-
S
P
I
K
I
W
T
S
K
Q
G
E
G
M
V
K
L
L
D
E
L
S
P
N
T
A
P
H
K
Y
Y
I
-----
G
F
R
Y
V
H
P
L
T
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
--
R
K
P
T
M
K
W
--
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
H
I
L
K
E
L
D
H
FPL
E
K
----
R
S
E
V
V
-----
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
C
N
P
-
Y
R
L
V
W
Q
S
K
V
-G
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
H
I
E
T
L
Y
E
L
D
I
E
Y
S
Q
V
-
L
A
K
E
C
G
V
E
-
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
NEL
C
S
K
Q
L
T
L
S
CPLCVN
P
V
C
R
E
T
K
S
F
F
T
S
QQL
22
HHSearch
75.32
19%
-21
- C3 -
-
1LBQ
-
HEMH_YEAST
B:
[38-362]
-------
P
T
G
I
V
L
M
N
M
G
G
P
S
K
V
--
E
E
T
Y
D
F
L
Y
Q
L
F
A
D
N
D
L
I
P
I
S
A
K
Y
Q
K
T
-
I
A
K
Y
I
A
K
F
R
T
P
K
I
E
K
Q
Y
R
E
I
G
----
G
G
S
P
I
R
K
W
S
E
Y
Q
A
T
E
V
C
K
I
L
D
K
T
C
P
E
T
A
P
H
K
P
Y
V
-----
A
F
R
Y
A
K
P
L
T
A
E
T
Y
K
Q
M
L
K
D
G
V
K
K
A
V
A
F
S
Q
Y
P
H
F
S
Y
S
T
T
G
S
S
I
N
E
L
W
R
Q
I
K
A
L
D
SE
R
S
I
S
--
W
--
S
V
I
D
R
W
P
T
N
E
G
L
I
K
A
F
S
E
N
I
T
K
K
L
Q
----
E
F
PQPV
R
D
K
V
V
-----
L
L
F
S
A
H
S
L
P
M
D
V
V
N
T
G
D
A
Y
P
A
E
V
A
A
T
V
Y
N
I
M
Q
K
L
K
F
-
K
N
P
Y
R
L
V
W
Q
S
Q
V
G
-
P
-
K
P
W
L
G
A
Q
T
A
E
I
A
E
F
L
G
--
P
K
V
D
G
L
M
F
I
P
I
A
F
T
S
D
H
I
E
T
L
H
E
I
D
L
G
V
-
I
G
-
E
-
S
E
-
Y
K
D
-
K
F
K
R
C
E
S
L
N
G
N
Q
T
F
I
E
G
M
A
D
L
V
K
S
H
L
Q
S
---
N
Q
L
--------------------------
23
HHSearch
74.97
22%
-21
- C3 -
-
3HCN
6
HEMH_HUMAN
A:
[1-330]
----
R
K
P
K
T
G
I
L
M
L
N
M
G
G
P
E
T
L
--
G
D
V
H
D
F
L
L
R
L
F
L
D
R
D
L
M
T
L
P
I
--
Q
N
K
-
L
A
P
F
I
A
K
R
R
T
P
K
I
Q
E
Q
Y
R
R
I
G
----
G
G
S
P
I
K
I
W
T
S
K
Q
G
E
G
M
V
K
L
L
D
E
L
S
P
N
T
A
P
H
K
Y
Y
I
-----
G
F
R
Y
V
H
P
L
T
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
RK
P
T
M
K
--
W
--
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
H
I
L
K
E
L
D
----
H
F
PLEK
R
S
E
V
V
-----
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
-
C
N
P
Y
R
L
V
W
Q
S
K
V
G
-
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
H
I
E
T
L
Y
E
L
D
I
E
Y
-
S
Q
-
V
L
A
K
E
C
G
V
E
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
---
N
E
L
--------------------------
24
HHSearch
74.86
20%
-37
- C3 -
-
2H1V
-
HEMH_BACSU
A:
[2-309]
----
S
R
K
K
M
G
L
L
V
M
A
Y
G
T
P
Y
K
E
--
E
D
I
E
R
Y
Y
T
H
I
R
R
G
R
K
P
E
P
----------------
E
M
L
Q
D
L
K
D
R
Y
E
A
I
G
----
G
I
S
P
L
A
Q
I
T
E
Q
Q
A
H
N
L
E
Q
H
L
N
E
I
Q
D
E
-
I
T
F
K
A
Y
I
-----
G
L
A
H
I
E
P
F
I
E
D
A
V
A
E
M
H
K
D
G
I
T
E
A
V
S
I
V
L
A
P
H
F
S
T
F
S
V
Q
S
Y
N
K
R
A
K
E
E
A
E
K
L
---
G
G
L
T
--
I
--
T
S
V
E
S
W
Y
D
E
P
K
F
V
T
Y
W
V
D
R
V
K
E
T
Y
A
----
S
M
P
E
D
E
R
E
N
A
M
-----
L
I
V
S
A
H
S
L
P
E
K
I
K
E
F
G
D
P
Y
P
D
Q
L
H
E
S
A
K
L
I
A
E
G
A
G
V
--
S
E
Y
A
V
G
W
Q
S
E
G
N
-
T
P
D
P
W
L
G
P
D
V
Q
D
L
T
R
D
L
F
E
Q
K
G
Y
Q
A
F
V
Y
V
P
V
G
F
V
A
D
H
L
E
V
L
Y
D
N
D
Y
E
C
-
K
V
-
V
-
T
D
D
I
G
A
-
S
Y
Y
R
P
E
M
P
N
A
K
P
E
F
I
D
A
L
A
T
V
V
L
K
K
L
G
---------------------------------
25
HHSearch
73.35
20%
-37
- C3 -
-
2Q2N
1
HEMH_BACSU
A:
[1-308]
----
S
R
K
K
M
G
L
L
V
M
A
Y
G
T
P
Y
K
E
--
E
D
I
E
R
Y
Y
T
H
I
R
R
G
R
K
P
E
P
----------------
E
M
L
Q
D
L
K
D
R
Y
E
A
I
G
----
G
I
S
P
L
A
Q
I
T
E
Q
Q
A
H
N
L
E
Q
H
L
N
E
I
Q
D
E
-
I
T
F
K
A
Y
I
-----
G
L
K
H
I
E
P
F
I
E
D
A
V
A
E
M
H
K
D
G
I
T
E
A
V
S
I
V
L
A
P
H
F
S
T
F
S
V
Q
S
Y
N
K
R
A
K
E
E
A
E
K
L
---
G
G
L
T
--
I
--
T
S
V
E
S
W
Y
D
E
P
K
F
V
T
Y
W
V
D
R
V
K
E
T
Y
A
----
S
M
P
E
D
E
R
E
N
A
M
-----
L
I
V
S
A
H
S
L
P
E
K
I
K
E
F
G
D
P
Y
P
D
Q
L
H
E
S
A
K
L
I
A
E
G
A
G
V
--
S
E
Y
A
V
G
W
Q
S
E
G
N
-
T
P
D
P
W
L
G
P
D
V
Q
D
L
T
R
D
L
F
E
Q
K
G
Y
Q
A
F
V
Y
V
P
V
G
F
V
A
D
H
L
E
V
L
Y
D
N
D
Y
E
C
-
K
V
-
V
-
T
D
D
I
G
A
-
S
Y
Y
R
P
E
M
P
N
A
K
P
E
F
I
D
A
L
A
T
V
V
L
K
K
L
G
---------------------------------
21
HHSearch
72.84
19%
-9
* C3 *
-
1LBQ
-
HEMH_YEAST
A:
[36-362]
-----
R
S
P
T
G
I
V
L
M
N
M
G
G
P
S
K
V
--
E
E
T
Y
D
F
L
Y
Q
L
F
A
D
N
D
L
I
P
I
S
A
K
Y
Q
K
T
-
I
A
K
Y
I
A
K
F
R
T
P
K
I
E
K
Q
Y
R
E
I
G
----
G
G
S
P
I
R
K
W
S
E
Y
Q
A
T
E
V
C
K
I
L
D
K
T
C
P
E
T
A
P
H
K
P
Y
V
-----
A
F
R
Y
A
K
P
L
T
A
E
T
Y
K
Q
M
L
K
D
G
V
K
K
A
V
A
F
S
Q
Y
P
H
F
S
Y
S
T
T
G
S
S
I
N
E
L
W
R
Q
I
K
A
L
D
SE
R
S
I
S
--
W
--
S
V
I
D
R
W
P
T
N
E
G
L
I
K
A
F
S
E
N
I
T
K
K
L
Q
----
E
F
PQPV
R
D
K
V
V
-----
L
L
F
S
A
H
S
L
P
M
D
V
V
N
T
G
D
A
Y
P
A
E
V
A
A
T
V
Y
N
I
M
Q
K
L
K
F
-
K
N
P
Y
R
L
V
W
Q
S
Q
V
G
-
P
-
K
P
W
L
G
A
Q
T
A
E
I
A
E
F
L
G
--
P
K
V
D
G
L
M
F
I
P
I
A
F
T
S
D
H
I
E
T
L
H
E
I
D
L
G
V
-
I
G
-
E
-
S
E
-
Y
K
D
-
K
F
K
R
C
E
S
L
N
G
N
Q
T
F
I
E
G
M
A
D
L
V
K
S
H
L
Q
S
---
N
Q
L
--------------------------
1
PsiBlast_PDB
71.28
23%
4
- C3 -
-
2PO7
4
HEMH_HUMAN
A:
[1-327]
----
R
K
P
K
T
G
I
L
M
L
N
M
G
G
P
E
--
T
L
G
D
V
H
D
F
L
L
R
L
F
L
D
Q
D
L
M
T
L
P
------
I
Q
N
K
L
A
-
P
F
I
A
K
R
L
T
P
K
I
Q
E
Q
Y
R
R
I
G
G
G
S
P
I
K
I
W
T
S
K
Q
G
E
G
M
V
K
L
L
D
----
E
-
L
S
P
N
T
A
P
H
K
Y
Y
I
G
F
R
Y
V
H
P
L
T
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
--
R
K
P
T
--
M
K
W
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
H
I
L
K
-
E
L
----
D
H
----
F
P
L
E
K
RSE
V
V
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
C
N
P
-
Y
R
L
V
W
Q
S
K
V
G
-
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
C
I
E
T
L
Y
E
L
D
I
E
Y
-
S
Q
V
L
A
K
E
C
G
V
E
-
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
--------------------------------
12
PsiBlast_PDB
64.75
25%
0
- C- -
-
3HCP
-
HEMH_HUMAN
A:
[107--35]
----------------------------------------------------------------------------------------------------------------------------
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
--
R
K
P
T
--
M
K
W
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
H
I
L
K
-
E
L
----
D
H
----
F
P
L
E
K
RSE
V
V
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
C
N
P
-
Y
R
L
V
W
Q
S
K
V
G
-
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
H
I
E
T
L
Y
E
L
D
I
E
Y
-
S
Q
V
L
A
K
E
C
G
V
E
-
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
--------------------------------
8
PsiBlast_PDB
64.75
25%
0
- C- -
-
3HCR
-
HEMH_HUMAN
A:
[107--35]
----------------------------------------------------------------------------------------------------------------------------
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
--
R
K
P
T
--
M
K
W
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
H
I
L
K
-
E
L
----
D
H
----
F
P
L
E
K
RSE
V
V
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
C
N
P
-
Y
R
L
V
W
Q
S
K
V
G
-
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
H
I
E
T
L
Y
E
L
D
I
E
Y
-
S
Q
V
L
A
K
E
C
G
V
E
-
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
--------------------------------
20
PsiBlast_PDB
63.32
25%
-1
- C3 -
-
4KLC
3
HEMH_HUMAN
A:
[118-338]
----------------------------------------------------------------------------------------------------------------------------
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
--
R
K
P
T
--
M
K
W
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
H
I
L
K
-
E
L
----
D
H
----
F
P
L
E
K
RSE
V
V
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
C
N
P
-
Y
R
L
V
W
Q
S
K
V
G
-
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
H
I
D
T
L
Y
E
L
D
I
E
Y
-
S
Q
V
L
A
K
E
C
G
V
E
-
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
--------------------------------
15
PsiBlast_PDB
62.80
25%
-7
- C3 -
-
4KMM
3
HEMH_HUMAN
A:
[118-338]
----------------------------------------------------------------------------------------------------------------------------
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
--
R
K
P
T
--
M
K
W
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
H
I
L
K
-
E
L
----
D
H
----
F
P
L
E
K
RSE
V
V
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
C
N
P
-
Y
R
L
V
W
Q
S
K
V
G
-
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
H
I
E
T
L
Y
E
L
D
I
E
Y
-
S
Q
V
L
A
K
E
C
G
V
E
-
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
--------------------------------
2
PsiBlast_PDB
62.51
25%
-13
- C3 -
-
3AQI
3
HEMH_HUMAN
A:
[107-327]
----------------------------------------------------------------------------------------------------------------------------
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
--
R
K
P
T
--
M
K
W
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
A
I
L
K
-
E
L
----
D
H
----
F
P
L
E
K
RSE
V
V
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
C
N
P
-
Y
R
L
V
W
Q
S
K
V
G
-
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
H
I
E
T
L
Y
E
L
D
I
E
Y
-
S
Q
V
L
A
K
E
C
G
V
E
-
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
--------------------------------
14
PsiBlast_PDB
62.13
25%
-12
- C3 -
-
4MK4
4
HEMH_HUMAN
A:
[107-327]
----------------------------------------------------------------------------------------------------------------------------
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
C
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
--
R
K
P
T
--
M
K
W
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
H
I
L
K
-
E
L
----
D
H
----
F
P
L
E
K
RSE
V
V
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
C
N
P
-
Y
R
L
V
W
Q
S
K
V
G
-
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
H
I
E
T
L
Y
E
L
D
I
E
Y
-
S
Q
V
L
A
K
E
C
G
V
E
-
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
--------------------------------
18
PsiBlast_PDB
61.71
25%
-8
- C3 -
-
2QD1
2
HEMH_HUMAN
A:
[107-327]
----------------------------------------------------------------------------------------------------------------------------
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
--
R
K
P
T
--
M
K
W
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
H
I
L
K
-
E
L
----
D
H
----
F
P
L
E
K
RSE
V
V
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
C
N
P
-
Y
R
L
V
W
Q
S
K
V
G
-
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
H
I
K
T
L
Y
E
L
D
I
E
Y
-
S
Q
V
L
A
K
E
C
G
V
E
-
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
--------------------------------
9
PsiBlast_PDB
61.61
25%
-10
- C3 -
-
1HRK
3
HEMH_HUMAN
A:
[107-327]
----------------------------------------------------------------------------------------------------------------------------
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
--
R
K
P
T
--
M
K
W
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
H
I
L
K
-
E
L
----
D
H
----
F
P
L
E
K
RSE
V
V
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
C
N
P
-
Y
R
L
V
W
Q
S
K
V
G
-
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
H
I
E
T
L
Y
E
L
D
I
E
Y
-
S
Q
V
L
A
K
E
C
G
V
E
-
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
--------------------------------
13
PsiBlast_PDB
61.50
25%
-11
- C3 -
-
3W1W
6
HEMH_HUMAN
A:
[119-339]
----------------------------------------------------------------------------------------------------------------------------
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
--
R
K
P
T
--
M
K
W
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
H
I
L
K
-
E
L
----
D
H
----
F
P
L
E
K
RSE
V
V
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
C
N
P
-
Y
R
L
V
W
Q
S
K
V
G
-
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
H
I
E
T
L
Y
E
L
D
I
E
Y
-
S
Q
V
L
A
K
E
C
G
V
E
-
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
--------------------------------
3
PsiBlast_PDB
61.46
25%
-6
- C3 -
-
2QD3
4
HEMH_HUMAN
A:
[107-327]
----------------------------------------------------------------------------------------------------------------------------
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
--
R
K
P
T
--
M
K
W
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
H
I
L
K
-
E
L
----
D
H
----
F
P
L
E
K
RSE
V
V
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
C
N
P
-
Y
R
L
V
W
Q
S
K
V
G
-
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
H
I
E
T
L
Y
E
L
D
I
E
Y
-
S
Q
V
L
A
K
E
C
G
V
E
-
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
--------------------------------
16
PsiBlast_PDB
61.19
25%
-8
- C3 -
-
4KLA
4
HEMH_HUMAN
A:
[107-327]
----------------------------------------------------------------------------------------------------------------------------
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
--
R
K
P
T
--
M
KW
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
H
I
L
K
-
E
L
----
D
H
----
F
P
L
E
K
RSE
V
V
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
C
N
P
-
Y
R
L
V
W
Q
S
K
V
G
-
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
H
I
D
T
L
Y
E
L
D
I
E
Y
-
S
Q
V
L
A
K
E
C
G
V
E
-
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
--------------------------------
4
PsiBlast_PDB
61.15
25%
-10
- C3 -
-
2QD4
4
HEMH_HUMAN
A:
[107-327]
----------------------------------------------------------------------------------------------------------------------------
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
--
R
K
P
T
--
M
K
W
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
H
I
L
K
-
E
L
----
D
H
----
F
P
L
E
K
RSE
V
V
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
C
N
P
-
Y
R
L
V
W
Q
S
K
V
G
-
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
H
I
E
T
L
Y
E
L
D
I
E
Y
-
S
Q
V
L
A
K
E
C
G
V
E
-
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
--------------------------------
17
PsiBlast_PDB
60.47
25%
-8
- C3 -
-
2HRE
2
HEMH_HUMAN
A:
[107-327]
----------------------------------------------------------------------------------------------------------------------------
E
E
A
I
E
E
M
E
R
D
G
L
E
R
A
I
A
F
T
Q
Y
P
Q
Y
S
C
S
T
T
G
S
S
L
N
A
I
Y
R
Y
Y
N
Q
V
G
--
R
K
P
T
--
M
K
W
S
T
I
D
R
W
P
T
H
H
L
L
I
Q
C
F
A
D
H
I
L
K
-
E
L
----
D
H
----
F
P
L
E
K
RSE
V
V
I
L
F
S
A
H
S
L
P
M
S
V
V
N
R
G
D
P
Y
P
Q
E
V
S
A
T
V
Q
K
V
M
E
R
L
E
Y
C
N
P
-
Y
R
L
V
W
Q
S
K
V
G
-
P
-
M
P
W
L
G
P
Q
T
D
E
S
I
K
G
L
C
E
-
R
G
R
K
N
I
L
L
V
P
I
A
F
T
S
D
H
I
K
T
L
Y
E
L
D
I
E
Y
-
S
Q
V
L
A
K
E
C
G
V
E
-
N
I
R
R
A
E
S
L
N
G
N
P
L
F
S
K
A
L
A
D
L
V
H
S
H
I
Q
S
--------------------------------