@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLF8: (2017-11-02 )
MNISKFFIDRPIFAGVLSVLILLAGLLSVFQLPISEYPEVVPPSVVVRAQYPGANPKVIAETVASPLEESINGVEDMLYMQSQANSDGNLTITVNFKLGIDPDKAQQLVQNRVYQAMPRLPEDVQRLGVTTLKSSPTLTMVVHLTSPDNRYDMTYLRNYAVLNVKDRLARLQGVGEVGLFGSGDYAMRVWLDPQKVAQRNLTATEIVNAIREQNIQVAAGTIGASPSNSPLQLSVNAQGRLTTEQEFADIILKTAPDGAVTRLGDVARVELAASQYGLRSLLDNKQAVAIPIFQAPGANALQVSDQVRSTMKELSKDFPSSIKYDIVYDPTQFVRASIKAVVHTLLEAIALVVVVVILFLQTWRASIIPLLAVPVSIIGTFALMLAFGYSINALSLFGMVLAIGIVVDDAIVVVENVERNIEAGLNPREATYGAMREVSGPIIAIALTLVAVFVPLAFMTGLTGQFYKQFAMTIAISTVISAFNSLTLSPALAALLLKGHDAKPDALTRIMNRVFGRFFALFNRVFSRASDRYSQGVSRVISHKASAMGVYAALLGLTVGISYIVPGGFVPAQDKQYLISFAQLPNGASLDRTEAVIRKMSDTALKQPGVESAVAFPGLSINGFTNSSSAGIVFVTLKPFDERKAKDLSANAIAGALNQKYSAIQDAYIAVFPPPPVMGLGTMGGFKLQLEDRGALGYSALNDAAQNFMKAAQSAPELGPMFSSYQINVPQLNVDLDRVKAKQQGVAVTDVFNTMQIYLGSQYVNDFNRFGRVYQVRAQADAPFRANPEDILQLKTRNSAGQMVPLSSLVNVTQTYGPEMVVRYNGYTSADINGGPAPGYSSSQAEAAVERIAAQTLPRGIKFEWTDLTYQKILAGNAGLWVFPISVLLVFLVLAAQYESLTLPLAVILIVPMGILAALTGVWLTAGDNNIFTQIGLMVLVGLACKNAILIVEFAQELEMQGATAFRAAVEASRLRLRPILMTSIAFIMGVVPLVTSTGAGSEMRHAMGVAVFFGMIGVSFFGLFLTPAFYVLIRTLNSKHKLHSAAVHEAPLASPHDH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.--......--240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420........430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560..---.....570.......580.......590.......600...--....610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720......----.730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950......-.960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
I
S
K
F
FIDR
P
I
F
A
G
V
L
S
V
L
I
L
L
A
G
L
L
S
V
F
QL
P
I
S
EYPEVVPP
S
V
V
V
R
A
QYPGA
N
P
K
V
I
A
E
T
V
A
S
P
L
E
E
S
I
N
G
V
E
D
M
L
Y
M
Q
SQANSDG
N
L
T
I
T
V
N
F
K
LGI
D
P
D
K
A
Q
Q
L
V
Q
N
R
V
Y
Q
AMPRL
P
E
D
V
Q
R
LG
V
T
TLKSSP
T
L
T
M
V
V
H
LTSPDNR
Y
D
M
T
Y
L
R
N
Y
A
VL
N
V
K
D
R
L
A
R
L
QGVGEVGLFGSG
D
Y
A
M
R
V
W
L
D
P
Q
K
V
A
Q
RNL
T
A
T
E
I
V
N
A
I
R
EQN
I
Q
V
A
AGTIGASPSNS
P
L
Q
L
--
S
VNAQG--RLT
T
E
Q
E
F
A
D
I
I
L
KTAPD
G
A
V
T
RLG
D
V
A
R
V
E
L
A
A
S
Q
Y
G
L
R
S
L
LDNK
Q
A
V
A
I
P
I
FQAPGAN
A
L
Q
V
S
D
Q
V
R
S
T
M
K
E
L
S
K
DFPSS
I
K
Y
D
I
V
YD
P
T
Q
F
V
R
A
S
I
K
A
V
V
H
T
L
L
E
A
I
A
L
V
V
V
V
V
I
L
F
L
Q
T
W
R
A
S
I
I
P
L
L
A
V
P
V
S
I
I
G
T
F
A
L
M
L
A
FGYS
I
N
A
L
S
L
F
G
M
V
L
A
I
G
I
VVD
D
A
I
V
V
V
E
N
V
E
R
N
I
-
E
AGLNP
R
E
A
T
Y
G
A
M
R
E
VSG
P
I
I
A
I
A
L
T
L
V
A
V
F
V
P
L
A
F
M
TG
L
T
G
Q
F
Y
K
Q
F
A
M
T
I
A
I
S
T
V
I
S
A
F
N
SL
T
L
S
P
A
L
A
A
L
L
LKGHDA
K
P
D
A
L
T
R
I
M
N
R
V
F
G
R
F
F
A
L
F
N
R
V
F
S
R
A
S
D
R
Y
S
Q
G
V
S
R
V
I
S
H
K
A
S
A
M
G
V
Y
A
A
L
L
G
L
T
V
G
I
S
Y
I---VPGGFVPAQ
D
K
Q
Y
L
I
S
F
A
QLPNGASL
D
R
T
E
A
V
I
R
K
M
S
D
T
A
L--KQPGVESAVAFPG
L
S
I
NGFTNSSSA
G
I
V
F
V
T
LKPF
D
E
R
K
AKDL
S
A
N
A
I
A
G
A
L
N
Q
K
Y
S
A
IQ
D
A
Y
I
A
V
FPPPPV
M
G
L
GTMG
G
F
K
L
Q
L
EDRGAL
G
Y
S
A
L
N
D
A
A
Q
N
F
M
K
A
A
QSAPELGPMFS
S
Y
Q
IN----V
P
Q
LNV
D
L
D
R
V
K
A
K
QQGV
A
V
T
D
V
F
N
T
M
Q
I
Y
L
G
S
Q
Y
V
N
D
F
N
RFG
R
V
Y
Q
V
R
AQADAPFRA
N
P
E
D
I
L
Q
LKTRNSAGQMV
P
L
S
S
L
V
N
V
T
Q
TYGP
E
M
V
V
R
YNG
Y
T
SADINGGPAPGYS
S
S
Q
A
E
A
A
V
E
R
I
A
A
Q
TLPRG
I
K
F
E
WTD
L
T
Y
Q
K
I
LAGNA
G
L
W
V
F
P
I
S
V
L
L
V
F
L
V
L
A
A
Q
YESL
T
L
P
L
A
V
I
L
I
V
P
M
G
I
L
A
A
L
T
G
V
W
L
TAGDN
N
I
F
T
Q
I
G
L
M
V
L
V
G
L
A
CK
N
A
I
L
I
V
E
F
A
Q
E
L
-
E
MQ
G
A
T
A
F
R
A
A
V
E
A
S
R
L
R
L
R
P
I
L
M
T
S
I
A
F
I
M
G
V
V
P
L
VTSTGA
G
S
E
M
R
H
A
M
G
V
A
V
F
F
G
M
I
G
V
S
F
F
G
L
F
L
T
P
A
F
Y
V
L
I
R
T
LNSKHKL
H
S
A
AVHEAPLASPHDH
1
PsiBlast_PDB
90.94
41%
-68
- C9 -
-
2V50
2
MEXB_PSEAE
A:
[4-1025]
-----
F
F
I
D
R
P
I
F
A
W
V
I
A
L
V
I
M
L
A
G
G
L
S
I
L
S
L
P
V
N
Q
Y
P
A
I
A
P
P
A
I
A
V
Q
V
S
Y
P
G
A
S
A
E
T
V
Q
D
T
V
V
Q
V
I
E
Q
Q
M
N
G
I
D
N
L
R
Y
I
S
S
E
S
N
S
D
G
S
M
T
I
T
V
T
F
E
Q
G
T
D
P
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
T
P
L
L
P
Q
E
V
Q
R
Q
G
I
R
V
T
K
A
V
K
N
F
L
M
V
V
G
V
V
S
T
D
G
S
M
T
K
E
D
L
S
N
Y
I
V
S
N
I
Q
D
P
L
S
R
T
K
G
V
G
D
F
Q
V
F
G
S
-
Q
Y
S
M
R
I
W
L
D
P
A
K
L
N
S
Y
Q
L
T
P
G
D
V
S
S
A
I
Q
A
Q
N
V
Q
I
S
S
G
Q
L
G
G
L
P
A
V
K
G
Q
Q
L
--
N
A
T
I
I
G
K
T
R
L
Q
T
A
E
Q
F
E
N
I
L
L
K
V
N
P
D
G
S
Q
V
R
L
K
D
V
A
D
V
G
L
G
G
Q
D
Y
S
I
N
A
Q
F
N
G
S
P
A
S
G
I
A
I
K
L
A
T
G
A
N
A
L
D
T
A
K
A
I
R
Q
T
I
A
N
L
E
P
F
M
P
Q
G
M
K
V
V
Y
P
Y
D
T
T
P
V
V
S
A
S
I
H
E
V
V
K
T
L
G
E
A
I
L
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
G
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
S
P
R
E
A
A
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
L
P
M
A
F
F
G
G
S
T
G
V
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
I
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
------------------
F
F
G
W
F
N
R
M
F
L
S
T
T
H
G
Y
E
R
G
V
A
S
I
L
K
H
R
A
P
Y
L
L
I
Y
V
V
I
V
A
G
M
I
W
M
F
T
R
---
I
P
T
A
F
L
P
D
E
D
Q
G
V
L
F
A
Q
V
Q
T
P
P
G
S
S
A
E
R
T
Q
V
V
V
D
S
M
R
E
Y
L
L
--
E
K
E
S
S
S
V
S
S
V
F
T
V
T
G
F
N
F
A
G
R
G
Q
S
S
G
M
A
F
I
M
L
K
P
W
E
E
R
P
G
G
E
N
S
V
F
E
L
A
K
R
A
Q
M
H
F
F
S
F
K
D
A
M
V
F
A
F
A
P
P
S
V
L
-----
T
G
F
D
L
F
L
Q
D
Q
A
G
V
G
H
E
V
L
L
Q
A
R
N
K
F
L
M
L
A
A
Q
N
P
A
L
Q
R
V
R
P
N
G
M
S
D
----
E
P
Q
Y
K
L
E
I
D
D
E
K
A
S
A
L
G
V
S
L
A
D
I
N
S
T
V
S
I
A
W
G
S
S
Y
V
N
D
F
I
D
R
G
R
V
K
R
V
Y
L
Q
G
R
P
D
A
R
M
N
P
D
D
L
S
K
W
Y
V
R
N
D
K
G
E
M
V
P
F
N
A
F
A
T
G
K
W
E
Y
G
S
P
K
L
E
R
Y
N
G
V
P
A
M
E
I
L
G
E
P
A
P
G
L
S
S
G
D
A
M
A
A
V
E
E
I
V
K
Q
-
L
P
K
G
V
G
Y
S
W
T
G
L
S
Y
E
E
R
L
S
G
S
Q
A
P
A
L
Y
A
L
S
L
L
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
T
S
M
R
G
L
S
N
D
V
F
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
E
L
-
H
E
Q
G
K
G
I
V
E
A
A
I
E
A
C
R
M
R
L
R
P
I
V
M
T
S
L
A
F
I
L
G
V
V
P
L
A
I
S
T
G
A
G
S
G
S
Q
H
A
I
G
T
G
V
I
G
G
M
V
T
A
T
V
L
A
I
F
W
V
P
L
F
Y
V
---------------------------
34
PsiBlast_CBE
90.82
41%
-51
- C9 -
-
4DX6
2
ACRB_ECOLI
C:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
NA
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
FVR
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
F
N
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GLED
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
81
PsiBlast_CBE
90.51
40%
-51
- C9 -
-
4U95
1
ACRB_ECOLI
C:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
NA
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
FVR
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GLED
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
A
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
38
PsiBlast_CBE
90.42
41%
-49
- C9 -
-
4DX7
11
ACRB_ECOLI
C:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
NA
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
FVR
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GLED
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
45
PsiBlast_CBE
90.06
41%
-50
- C9 -
-
2J8S
5
ACRB_ECOLI
C:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
NA
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
FVR
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GLED
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
75
PsiBlast_CBE
90.04
40%
-50
- C9 -
-
4U8Y
2
ACRB_ECOLI
C:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
NA
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
N
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
FVR
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GLED
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
84
PsiBlast_CBE
89.96
40%
-50
- C9 -
-
4U96
2
ACRB_ECOLI
C:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
NA
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
FVR
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GLED
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
A
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
32
PsiBlast_CBE
89.93
41%
-68
- C9 -
-
2V50
2
MEXB_PSEAE
D:
[1-1025]
--
M
S
K
F
F
I
D
R
P
I
F
A
W
V
I
A
L
V
I
M
L
A
G
G
L
S
I
L
S
L
P
V
N
Q
Y
P
A
I
A
P
P
A
I
A
V
Q
V
S
Y
P
G
A
S
A
E
T
V
Q
D
T
V
V
Q
V
I
E
Q
Q
M
N
G
I
D
N
L
R
Y
I
S
S
E
S
N
S
D
G
S
M
T
I
T
V
T
F
E
Q
G
T
D
P
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
T
P
L
L
P
Q
E
V
Q
R
Q
G
I
R
V
T
K
A
V
K
N
F
L
M
V
V
G
V
V
S
T
D
G
S
M
T
K
E
D
L
S
N
Y
I
V
S
N
I
Q
D
P
L
S
R
T
K
G
V
G
D
F
Q
V
F
G
S
-
Q
Y
S
M
R
I
W
L
D
P
A
K
L
N
S
Y
Q
L
T
P
G
D
V
S
S
A
I
Q
A
Q
N
V
Q
I
S
S
G
Q
L
G
G
L
P
A
V
K
G
Q
Q
L
--
N
A
T
I
I
G
K
T
R
L
Q
T
A
E
Q
F
E
N
I
L
L
K
---------
L
K
D
V
A
D
V
G
L
G
G
Q
D
Y
S
I
N
A
Q
F
N
G
S
P
A
S
G
I
A
I
K
L
A
T
G
A
N
A
L
D
T
A
K
A
I
R
Q
T
I
A
N
L
E
P
F
M
P
Q
G
M
K
V
V
Y
P
Y
D
T
T
P
V
V
S
A
S
I
H
E
V
V
K
T
L
G
E
A
I
L
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
G
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
S
P
R
E
A
A
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
L
P
M
A
F
F
G
G
S
T
G
V
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
I
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
------------------
F
F
G
W
F
N
R
M
F
L
S
T
T
H
G
Y
E
R
G
V
A
S
I
L
K
H
R
A
P
Y
L
L
I
Y
V
V
I
V
A
G
M
I
W
M
F
T
R
---
I
P
T
A
F
L
P
D
E
D
Q
G
V
L
F
A
Q
V
Q
T
P
P
G
S
S
A
E
R
T
Q
V
V
V
D
S
M
R
E
Y
L
L
--
E
K
E
S
S
S
V
S
S
V
F
T
V
T
G
F
N
F
A
G
R
G
Q
S
S
G
M
A
F
I
M
L
K
P
W
E
E
R
P
G
G
E
N
S
V
F
E
L
A
K
R
A
Q
M
H
F
F
S
F
K
D
A
M
V
F
A
F
A
P
P
------
N
A
T
G
F
D
L
F
L
Q
D
Q
A
G
V
G
H
E
V
L
L
Q
A
R
N
K
F
L
M
L
A
A
Q
N
P
A
L
Q
R
V
R
P
N
G
M
S
D
----
E
P
Q
Y
K
L
E
I
D
D
E
K
A
S
A
L
G
V
S
L
A
D
I
N
S
T
V
S
I
A
W
G
S
S
Y
V
N
D
F
I
D
R
G
R
V
K
R
V
Y
L
Q
G
R
P
D
A
R
M
N
P
D
D
L
S
K
W
Y
V
R
N
D
K
G
E
M
V
P
F
N
A
F
A
T
G
K
W
E
Y
G
S
P
K
L
E
R
Y
N
G
V
P
A
M
E
I
L
G
E
P
A
P
G
L
S
S
G
D
A
M
A
A
V
E
E
I
V
K
Q
-
L
P
K
G
V
G
Y
S
W
T
G
L
S
Y
E
E
R
L
S
G
S
Q
A
P
A
L
Y
A
L
S
L
L
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
T
S
M
R
G
L
S
N
D
V
F
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
E
L
-
H
E
Q
G
K
G
I
V
E
A
A
I
E
A
C
R
M
R
L
R
P
I
V
M
T
S
L
A
F
I
L
G
V
V
P
L
A
I
S
T
G
A
G
S
G
S
Q
H
A
I
G
T
G
V
I
G
G
M
V
T
A
T
V
L
A
I
F
W
V
P
L
F
Y
V
---------------------------
40
PsiBlast_CBE
89.90
41%
-50
- C9 -
-
4DX5
19
ACRB_ECOLI
C:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
NA
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
FVR
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GLED
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
17
PsiBlast_PDB
89.84
41%
-47
- C9 -
-
5JMN
10
?
A:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
N
A
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
F
V
R
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
T
K
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
-
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
G
L
E
D
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
78
PsiBlast_CBE
89.76
40%
-51
- C9 -
-
4U8V
1
ACRB_ECOLI
C:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
NA
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
N
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
FVR
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GLED
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
58
PsiBlast_CBE
89.68
41%
-53
- C9 -
-
5NC5
3
ACRB_ECOLI
C:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
NA
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
FVR
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GLED
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
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A
A
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G
G
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Y
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D
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A
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Y
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D
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A
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Q
M
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A
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G
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L
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R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
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M
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Y
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L
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Q
A
P
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L
Y
A
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L
I
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V
F
L
C
L
A
A
L
Y
E
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W
S
I
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F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
39
PsiBlast_CBE
89.66
41%
-49
- C9 -
-
4DX7
11
ACRB_ECOLI
B:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
NA
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
FVR
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GLED
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
36
PsiBlast_CBE
89.57
41%
-49
- C9 -
-
5JMN
3
?
C:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
NA
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
FVR
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GLED
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
77
PsiBlast_CBE
89.47
40%
-47
- C9 -
-
4U8Y
2
ACRB_ECOLI
A:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
N
A
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
N
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
F
V
R
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GL
E
D
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
72
PsiBlast_CBE
89.30
41%
-46
- C9 -
-
4ZIT
1
ACRB_ECOLI
A:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
N
A
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
F
V
R
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
T
K
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GLED
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
70
PsiBlast_CBE
89.28
41%
-48
- C9 -
-
4ZIT
1
ACRB_ECOLI
C:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
NA
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
FVR
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GLED
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
83
PsiBlast_CBE
89.27
40%
-47
- C9 -
-
4U95
1
ACRB_ECOLI
A:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
N
A
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
F
V
R
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GL
E
D
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
A
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
108
PsiBlast_CBE
89.25
41%
-50
- C9 -
-
4ZJO
1
ACRB_ECOLI
B:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
NA
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
FVR
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
A
G
A
A
G
A
G
Q
N
T
--
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GLED
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
-
L
P
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
T
F
R
G
L
T
N
D
V
Y
F
Q
V
G
L
L
T
T
I
G
L
S
A
K
N
A
I
L
I
V
E
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
I
S
T
G
A
G
S
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
------------------------------------------
59
PsiBlast_CBE
89.21
41%
-51
- C9 -
-
5NC5
14
ACRB_ECOLI
B:
[3-1012]
----
N
F
F
I
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
S
N
S
D
S
T
G
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
S
S
S
F
L
M
V
V
G
V
I
N
T
D
G
T
M
T
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
-
Q
Y
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
NA
S
I
I
A
Q
T
--
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
F
F
G
G
S
T
G
A
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
-
P
I
A
K
G
D
-----
H
G
E
G
K
K
G
F
F
G
W
F
N
R
M
F
E
K
S
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
---
L
I
I
V
V
G
M
A
Y
L
FVR
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TK
E
K
N
N
V
E
S
V
F
A
V
N
G
F
G
F
A
G
--
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
W
A
D
R
P
G
E
E
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
K
D
A
M
V
F
A
F
N
L
P
A
I
V
E
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---
M
L
T
S
V
R
P
N
GLED
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
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R
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K
V
Y
V
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A
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Y
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M
L
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D
D
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D
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Y
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A
A
D
G
Q
M
V
P
F
S
A
F
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S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
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