@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLH0: (2017-11-02 )
MNTSLRLNHYWITCADGLETLLQEEIEQLGTKVTERKAGRLIIEGTLEHAYRICMWSRLASRVLLPIHTYELERTHDARDVAEELYEGAISFDWSLIFAPQSTFAIRLHAEREIKVNTQFATLRVKDGVVDSFMEAVGRRPSIDTKQPEITLYVLAGKTEHTYCLDLSGDSLHKRGYRRFMTDAPIKENLAAAILQKAKLQERNPEIVLDPMCGSGTFIIEALMILTDRAPGLVRRFGFNGWHGHDRELWLSLKAEAAERHEKALEQPLPKFYAYDADWEAVKATRENIIAAGFEKLLGDIQIEERTLADWPDFGAENKTAFIVTNPPYGERLGDKASNRSLYLGLSALLQKNFPNQYAAIIAAQIEQADVLAFEAPETLRLMNGKLPIYVRFGTVKLEKVTQPFLANWQAQPVEMEEAQDFANRLQKNMTALKKWATKENIYCLRLYDADLPDFNLAVDLYSDRLHVQEYAPPKKIDPEKAKKRFNLALAAIRAVTGLNRDAIFIKTRARQTGTNQYTKQSTANKRFIVQEGKAKILVNLTDYLDTGLFLDHRQMRLRIAQEARGKHFLNLYSYTSTASLHAALGGAASTTSVDLSNTYLSWSKENFVLNGLTVDHADEQHMFFASDCFEWLKEGHEQYDLIFIDPPTFSNSKKFHGTFDVQRDHVSLIKRAMNRLTSEGTLYFSNNYRGFEMDEEIEALYDVEEITSETIGPDFKRNQKIHRAWKIQHPGLN
Atome Classification :
(20 SA)
.........10........20........30-----..---.--...----.---..40....-------------.-------------...50........60........70..--.-.-.-...80........90........100....--------...110.-....-...120.......130.......140--.....--..150.......160.......-170........180.......190.......200.....-..210.......220.......230...-....240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.-------...-------------...350-.--......360.....--..370.......380.......390-.......400.......410.......420.......430.......440.......450...-.-...460.......470.......480.......490.......500.......510--...-..-...---520.......530.......540.......550.......560.-......570.......580.......590.......600.......610.......620.......630...---....---640.......650.......660.......670.......680.......690---...-..------.------.--700...------.....710.......720..-----.-------....730..-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNT
S
L
R
L
N
H
Y
W
I
T
C
A
D
G
L
E
T
L
L
Q
E
E
I
E
Q
L
G
------
T
K
---
V
--
T
ER----K---A
G
R
L
I
I
E
G
-------------
T
-------------
L
E
H
A
Y
R
I
C
M
W
S
R
L
A
S
R
V
L
L
P
I
H
T
Y
E
LE--R-T-H-
D
A
R
D
V
A
E
E
L
Y
E
G
AISFD
W
S
L
I
FAPQ
S
T
F
A
I
--------
R
L
H
A
E
-
R
-
E
I
K
V
-
N
T
Q
F
A
T
L
R
VKD
G
V
V
D
S
F
M
E
A
VGRRPS--IDTKQ--P
E
I
T
L
Y
V
L
AGKT
E
H
T
Y
C
L
DLSG-D-
S
L
H
K
R
G
Y
R
R
FMTDAP
I
K
E
N
L
A
A
A
I
L
Q
K
A
K
LQERNP
E
I
-
V
L
DPMCGS
G
T
F
I
I
E
A
L
M
I
LTDRA
P
G
L
V
R
-
R
FGFNGWHGHD
R
E
L
W
L
S
L
K
A
E
A
A
E
R
H
E
K
A
L
EQP
L
P
K
FYAYDA
D
W
E
A
V
K
A
T
R
E
N
I
I
A
A
G
F
E
K
L
L
G
D
I
Q
I
EERTLADWPDFGAEN
K
T
A
F
I
V
TNPPY
G
E
RLGDKASNRS
L
Y
-------
L
G
L
-------------
S
A
L
L
Q
K-N--F
P
N
Q
Y
A
A
I
I
A
A
Q
IE--Q
A
D
V
L
A
FEAP
E
T
L
R
LMNGKL
P
I
Y
V
R
-FG
T
V
K
L
E
KV
T
Q
P
F
L
ANWQAQP
V
E
M
E
E
A
Q
D
F
A
N
R
L
Q
K
N
M
T
A
L
K
K
WATKE
N
I
Y
C
L
R
L
YDADLPDF-
N
-
L
A
V
D
LYSD
R
L
H
VQEYAPPKKI
D
P
E
K
A
K
K
R
F
N
L
A
L
A
A
I
R
A
V
TGLNR
D
A
I
F
I
K
TRAR---QTG-TN-QYT---KQSTAN
K
R
F
I
V
QEG
K
A
K
I
L
V
N
L
T
D
YLDTGL
F
L
D
H
R
Q
M
R
L
R
I
A
Q
E
-ARGK
H
F
L
N
L
Y
SYTS
T
A
S
L
H
A
ALGGAAS
T
T
S
V
DLSN
T
Y
LSWSKE
N
F
V
L
N
G
L
T
VDHADEQ
H
M
F
F
A
S
D
C
F
E
W
L
K
E---GHEQ---Y
D
L
I
F
IDPPTFSNSK
K
F
H
G
T
F
D
V
Q
R
D
H
V
S
L
I
K
R
A
M
N
R
LTSE
G
T
L
Y
FSNNYRGF---E
M
D
-
E
E
------
I
------
E
--
A
L
-
Y
D
V
------
E
E
I
T
S
E
TIGP
D
F
K
RN
Q
K
I
H
R
-----
A
-------
W
K
IQHPGLN-
36
HHSearch
86.57
43%
-33
- C1 -
-
3V97
6
RLMKL_ECOLI
A:
[1-702]
-----
A
M
N
S
L
F
A
S
T
A
R
G
L
E
E
L
L
K
T
E
L
E
N
L
G
------
A
V
---
E
--
C
Q
V
----
V
---
Q
G
G
V
H
F
K
G
-------------
D
-------------
T
R
L
V
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
K
V
-----------
Y
-
S
D
L
D
L
Y
L
G
V
Q
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
--------
H
F
S
G
L
-
N
-
D
T
I
R
-
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
K
N
L
P
R
P
N
--
V
D
R
D
A
--
P
D
I
R
V
N
V
W
L
H
K
E
T
A
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
R
A
G
I
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
--
G
T
P
-
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
Y
S
S
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
---
I
T
F
E
V
K
D
V
A
Q
L
T
N
P
L
P
K
G
P
Y
G
T
V
L
S
N
P
P
Y
G
E
---
S
E
P
A
L
I
A
L
H
-------
S
L
L
-------------
G
R
I
M
K
N
-
Q
--
F
G
G
W
N
L
S
L
F
S
A
S
P
D
--
L
L
S
C
L
Q
L
R
A
D
K
Q
Y
K
A
K
N
G
P
L
D
C
V
Q
K
-
N
Y
H
V
A
E
S
-----------------
M
V
A
E
D
Y
T
N
R
L
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
I
E
C
Y
R
L
Y
D
A
D
L
P
E
Y
-
N
-
V
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
-------
H
K
A
R
Q
R
L
F
D
I
I
A
A
T
I
S
V
L
G
I
A
P
N
K
L
V
L
K
T
R
E
-------------------
E
K
-
G
E
F
L
E
V
T
E
Y
N
A
H
L
W
V
N
L
T
D
Y
L
D
T
G
L
F
L
D
H
R
I
A
R
R
M
L
G
Q
M
-
S
K
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G
A
R
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
G
L
T
----
G
R
A
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
---
A
N
E
Q
---
F
D
L
I
F
I
D
P
P
T
F
S
-------
A
F
D
V
Q
R
D
H
L
A
L
M
K
D
L
K
R
L
L
R
A
G
G
T
I
M
F
S
N
N
K
R
G
F
---
R
M
D
-
L
D
------
G
------
L
A
K
L
G
-
L
K
A
------
Q
E
I
T
Q
K
T
L
S
Q
D
F
A
R
N
R
Q
I
H
N
-----
C
-------
W
L
I
T
A
-----
27
Fugue
85.94
42%
-31
- C1 -
-
3V97
6
RLMKL_ECOLI
A:
[1-703]
-----
A
M
N
S
L
F
A
S
T
A
R
G
L
E
E
L
L
K
T
E
L
E
N
L
G
------
A
V
---
E
--
C
Q
V
----
V
---
Q
G
G
V
H
F
K
G
-------------
D
-------------
T
R
L
V
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
K
V
Y
--
S
----------
D
L
D
L
Y
L
G
V
Q
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
--------
H
F
S
G
L
-
N
-
D
T
I
R
-
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
K
N
L
P
R
P
N
--
V
D
R
D
A
--
P
D
I
R
V
N
V
W
L
H
K
E
T
A
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
R
A
G
I
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
---
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
Y
S
S
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
---
I
T
F
E
V
K
D
V
A
Q
L
T
N
P
L
P
K
G
P
Y
G
T
V
L
S
N
P
P
Y
G
E
---
S
E
P
A
L
I
A
L
H
-------
S
L
L
-------------
G
R
I
M
K
N
-
Q
--
F
G
G
W
N
L
S
L
F
S
A
S
P
D
--
L
L
S
C
L
Q
L
R
A
D
K
Q
Y
K
A
K
N
G
P
L
D
C
V
Q
K
-
N
Y
H
V
A
-----------------
E
S
M
V
A
E
D
Y
T
N
R
L
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
I
E
C
Y
R
L
Y
D
A
D
L
P
E
Y
-
N
-
V
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
H
-------
K
A
R
Q
R
L
F
D
I
I
A
A
T
I
S
V
L
G
I
A
P
N
K
L
V
L
K
T
R
E
E
---
K
-----------------
G
E
F
L
E
V
T
E
Y
N
A
H
L
W
V
N
L
T
D
Y
L
D
T
G
L
F
L
D
H
R
I
A
R
R
M
L
G
Q
M
-
S
K
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G
A
R
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
G
L
T
----
G
R
A
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
---
A
N
E
Q
---
F
D
L
I
F
I
D
P
P
T
F
S
A
-------
F
D
V
Q
R
D
H
L
A
L
M
K
D
L
K
R
L
L
R
A
G
G
T
I
M
F
S
N
N
K
R
G
F
---
R
M
D
L
D
G
------
L
------
A
--
K
L
G
L
K
A
------
Q
E
I
T
Q
K
T
L
S
Q
D
F
A
R
N
R
Q
I
H
N
-----
C
-------
W
L
I
T
A
A
----
35
HHSearch
84.49
43%
-36
- C1 -
-
3V97
6
RLMKL_ECOLI
B:
[2-702]
------
M
N
S
L
F
A
S
T
A
R
G
L
E
E
L
L
K
T
E
L
E
N
L
G
------
A
V
---
E
--
C
Q
V
----
V
---
Q
G
G
V
H
F
K
G
-------------
D
-------------
T
R
L
V
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
K
V
-----------
Y
-
S
D
L
D
L
Y
L
G
V
Q
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
--------
H
----------
R
-
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
---
P
R
P
N
--
V
D
R
D
A
--
P
D
I
R
V
N
V
W
------
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
---
I
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
--
G
T
P
-
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
Y
S
S
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
---
I
T
F
E
V
K
D
V
A
Q
L
T
N
P
L
P
K
G
P
Y
G
T
V
L
S
N
P
P
Y
-----
S
E
P
A
L
I
A
L
H
-------
S
L
L
-------------
G
R
I
M
K
N
-
Q
--
F
G
G
W
N
L
S
L
F
S
A
S
P
D
--
L
L
S
C
L
Q
L
R
A
D
K
Q
Y
K
A
K
N
G
P
L
D
C
V
Q
K
-
N
Y
H
V
A
E
S
--------------------
E
D
Y
T
N
R
L
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
I
E
C
Y
R
L
Y
D
A
D
L
P
E
Y
-
N
-
V
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
-------
H
K
A
R
Q
R
L
F
D
I
I
A
A
T
I
S
V
L
G
I
A
P
N
K
L
V
L
K
T
R
E
--------------------
K
-
G
E
F
L
E
V
T
E
Y
N
A
H
L
W
V
N
L
T
D
Y
L
D
T
G
L
F
L
D
H
R
I
A
R
R
M
L
G
Q
M
-
S
K
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G
A
R
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
G
L
T
----
G
R
A
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
---
A
N
E
Q
---
F
D
L
I
F
I
D
P
P
T
F
S
N
------
A
F
D
V
Q
R
D
H
L
A
L
M
K
D
L
K
R
L
L
R
A
G
G
T
I
M
F
S
N
N
K
R
G
F
---
R
M
D
-
L
D
------
G
------
L
A
K
L
G
-
L
K
A
------
Q
E
I
T
Q
K
T
L
S
Q
D
F
A
R
N
R
Q
I
H
N
-----
C
-------
W
L
I
T
A
-----
1
PsiBlast_PDB
82.91
41%
-23
- C1 -
-
3V97
6
RLMKL_ECOLI
A:
[2-700]
------
M
N
S
L
F
A
S
T
A
R
G
L
E
E
L
L
K
T
E
L
E
N
L
G
------
A
V
---
E
--
C
Q
V
----
V
---
Q
G
G
V
H
F
K
G
-------------
D
-------------
T
R
L
V
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
K
V
Y
--
S
-
D
-
L
-
D
-------
L
Y
L
G
V
Q
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
--------
H
F
S
G
L
-
N
-
D
T
I
R
-
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
K
N
L
P
R
P
N
--
V
D
R
D
A
--
P
D
I
R
V
N
V
W
L
H
K
E
T
A
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
R
A
G
I
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
---
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
Y
S
S
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
---
I
T
F
E
V
K
D
V
A
Q
L
T
N
P
L
P
K
G
P
Y
G
T
V
L
S
N
P
P
Y
G
E
---
S
E
P
A
L
I
A
L
H
-------
S
L
L
-------------
G
R
I
M
K
N
-
Q
--
F
G
G
W
N
L
S
L
F
S
A
S
P
D
--
L
L
S
C
L
Q
L
R
A
D
K
Q
Y
K
A
K
N
G
P
L
D
C
V
Q
K
N
Y
H
V
A
E
S
-------
M
V
-----------
A
E
D
Y
T
N
R
L
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
I
E
C
Y
R
L
Y
D
A
D
L
P
E
Y
-
N
-
V
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
-------
H
K
A
R
Q
R
L
F
D
I
I
A
A
T
I
S
V
L
G
I
A
P
N
K
L
V
L
K
T
R
E
--------------------
E
K
G
E
F
L
E
V
T
E
Y
N
A
H
L
W
V
N
L
T
D
Y
L
D
T
G
L
F
L
D
H
R
I
A
R
R
M
L
G
Q
M
-
S
K
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G
A
R
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
G
L
T
----
G
R
A
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
---
A
N
E
Q
---
F
D
L
I
F
I
D
P
P
T
F
S
-------
A
F
D
V
Q
R
D
H
L
A
L
M
K
D
L
K
R
L
L
R
A
G
G
T
I
M
F
S
N
N
K
R
G
F
---
R
M
D
-
L
D
------
G
------
L
--
A
K
-
L
G
L
K
A
----
Q
E
I
T
Q
K
T
L
S
Q
D
F
A
R
N
R
Q
I
H
N
-----
C
-------
W
L
I
-------
22
PsiBlast_CBE
81.27
41%
-30
* C1 *
-
3V97
6
RLMKL_ECOLI
B:
[2-700]
------
M
N
S
L
F
A
S
T
A
R
G
L
E
E
L
L
K
T
E
L
E
N
L
G
------
A
V
---
E
--
C
Q
V
----
V
---
Q
G
G
V
H
F
K
G
-------------
D
-------------
T
R
L
V
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
K
V
Y
--
S
-
D
-
L
-
D
-------
L
Y
L
G
V
Q
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
--------
H
----------
R
-
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
---
P
R
P
N
--
V
D
R
D
A
--
P
D
I
R
V
N
V
W
------
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
---
I
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
---
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
Y
S
S
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
---
I
T
F
E
V
K
D
V
A
Q
L
T
N
P
L
P
K
G
P
Y
G
T
V
L
S
N
P
P
Y
-----
S
E
P
A
L
I
A
L
H
-------
S
L
L
-------------
G
R
I
M
K
N
-
Q
--
F
G
G
W
N
L
S
L
F
S
A
S
P
D
--
L
L
S
C
L
Q
L
R
A
D
K
Q
Y
K
A
K
N
G
P
L
D
C
V
Q
K
N
Y
H
V
A
E
S
---------------------
E
D
Y
T
N
R
L
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
I
E
C
Y
R
L
Y
D
A
D
L
P
E
Y
-
N
-
V
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
-------
H
K
A
R
Q
R
L
F
D
I
I
A
A
T
I
S
V
L
G
I
A
P
N
K
L
V
L
K
T
R
E
---------------------
K
G
E
F
L
E
V
T
E
Y
N
A
H
L
W
V
N
L
T
D
Y
L
D
T
G
L
F
L
D
H
R
I
A
R
R
M
L
G
Q
M
-
S
K
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G
A
R
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
G
L
T
----
G
R
A
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
---
A
N
E
Q
---
F
D
L
I
F
I
D
P
P
T
F
S
N
------
A
F
D
V
Q
R
D
H
L
A
L
M
K
D
L
K
R
L
L
R
A
G
G
T
I
M
F
S
N
N
K
R
G
F
---
R
M
D
-
L
D
------
G
------
L
--
A
K
-
L
G
L
K
A
----
Q
E
I
T
Q
K
T
L
S
Q
D
F
A
R
N
R
Q
I
H
N
-----
C
-------
W
L
I
-------
21
PsiBlast_CBE
80.18
41%
-30
- C1 -
-
3V8V
2
RLMKL_ECOLI
B:
[1-699]
------
M
N
S
L
F
A
S
T
A
R
G
L
E
E
L
L
K
T
E
L
E
N
L
G
------
A
V
---
E
--
C
Q
V
----
V
---
Q
G
G
V
H
F
K
G
-------------
D
-------------
T
R
L
V
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
--
Y
--
S
-
D
-
L
-
D
-------
L
Y
L
G
V
Q
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
--------
H
----------
R
-
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
---
P
R
P
N
--
V
D
R
D
A
--
P
D
I
R
V
N
V
W
-------
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
----
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
---
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
Y
S
S
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
---
I
T
F
E
V
K
D
V
A
Q
L
T
N
P
L
P
K
G
P
Y
G
T
V
L
S
N
P
P
Y
-----
S
E
P
A
L
I
A
L
H
-------
S
L
L
-------------
G
R
I
M
K
N
-
Q
--
F
G
G
W
N
L
S
L
F
S
A
S
P
D
--
L
L
S
C
L
Q
L
R
A
D
K
Q
Y
K
A
K
N
G
P
L
D
C
V
Q
K
N
Y
H
V
A
E
S
---------------------
E
D
Y
T
N
R
L
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
I
E
C
Y
R
L
Y
D
A
D
L
P
E
Y
-
N
-
V
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
-------
H
K
A
R
Q
R
L
F
D
I
I
A
A
T
I
S
V
L
G
I
A
P
N
K
L
V
L
K
T
R
----------------------
K
G
E
F
L
E
V
T
E
Y
N
A
H
L
W
V
N
L
T
D
Y
L
D
T
G
L
F
L
D
H
R
I
A
R
R
M
L
G
Q
M
-
S
K
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G
A
R
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
G
L
T
----
G
R
A
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
---
A
N
E
Q
---
F
D
L
I
F
I
D
P
P
T
F
S
N
------
A
F
D
V
Q
R
D
H
L
A
L
M
K
D
L
K
R
L
L
R
A
G
G
T
I
M
F
S
N
N
K
R
G
F
---
R
M
D
-
L
D
------
G
------
L
--
A
K
-
L
G
L
K
A
----
Q
E
I
T
Q
K
T
L
S
Q
D
F
A
R
N
R
Q
I
H
N
-----
C
-------
W
L
I
-------
37
HHSearch
63.94
27%
-111
- C1 -
-
3K0B
2
?
A:
[10-384]
--
Q
G
M
K
S
F
Q
L
V
A
T
A
A
S
G
L
E
A
I
V
G
K
E
V
A
R
L
G
------
Y
D
------
P
K
V
----
E
---
N
G
K
V
Y
F
E
G
-------------
D
-------------
L
S
A
I
A
R
A
N
L
W
L
R
V
A
D
R
V
K
I
V
V
G
V
F
K
A
-----------
T
-
T
F
D
E
L
F
E
K
T
K
A
L
P
W
E
D
Y
L
P
L
D
A
Q
F
P
V
--------
A
G
K
S
V
-
K
-
S
T
L
Y
-
S
V
P
D
C
Q
A
I
V
K
K
A
I
V
N
R
V
S
E
K
Y
R
R
S
G
R
--
L
M
E
T
G
--
A
L
F
K
L
E
V
S
I
L
K
D
E
V
T
L
T
I
D
T
S
G
-
A
-
G
L
H
K
R
G
Y
R
L
A
Q
G
S
A
P
I
K
E
T
M
A
A
A
L
V
L
L
T
S
W
H
P
--
D
R
P
-
F
Y
D
P
V
C
G
S
G
T
I
P
I
E
A
A
L
I
G
Q
N
I
A
P
G
F
N
R
-
E
F
V
S
E
T
W
D
W
M
P
K
Q
V
W
A
D
A
R
Q
E
A
E
D
L
A
N
Y
D
Q
P
---
L
N
I
I
G
G
D
I
D
A
R
L
I
E
I
A
K
Q
N
A
V
E
A
G
L
G
D
L
---
I
T
F
R
Q
L
Q
V
A
D
F
Q
T
---
E
D
E
Y
G
V
V
V
A
N
P
P
Y
G
E
R
L
E
D
E
E
A
V
R
Q
L
Y
-------
R
E
M
-------------
G
I
V
Y
K
R
----
M
P
T
W
S
V
Y
V
L
T
S
Y
E
L
--
F
E
E
V
Y
G
K
K
A
T
K
K
R
K
L
Y
----
R
T
D
L
Y
-
Q
Y
W
G
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
53.23
29%
-27
- C1 -
-
3LDU
12
?
A:
[5-383]
-----
K
N
Y
T
L
I
S
P
C
F
F
G
M
E
K
M
L
A
R
E
I
T
N
L
G
------
Y
E
---
I
--
I
K
T
----
E
---
D
G
R
I
T
Y
K
T
-------------
D
-------------
E
F
G
I
A
K
S
N
M
W
L
R
C
A
E
R
V
H
L
K
I
A
E
F
E
A
-----------
K
-
S
F
D
E
L
F
E
N
T
K
R
I
N
W
S
R
Y
I
P
Y
G
A
Q
F
P
I
--------
S
K
A
S
S
I
K
-
S
K
L
Y
-
S
T
P
D
V
Q
A
I
V
K
K
A
I
V
E
S
L
K
K
S
Y
L
E
D
G
L
--
L
K
E
D
K
--
E
K
Y
P
I
F
V
F
I
H
K
D
K
V
T
I
S
I
D
T
T
G
-
D
-
A
L
H
K
R
G
Y
R
E
K
--
K
A
P
I
R
E
T
L
A
A
G
L
I
Y
L
T
P
W
K
A
--
G
R
V
-
L
V
D
P
M
C
G
S
G
T
I
L
I
E
A
A
M
I
G
I
N
M
A
P
G
L
N
R
-
E
F
I
S
E
K
W
R
T
L
D
K
K
I
W
W
D
V
R
K
D
A
F
N
K
I
D
N
E
S
K
---
F
K
I
Y
G
Y
D
I
D
E
E
S
I
D
I
A
R
E
N
A
E
I
A
G
V
D
E
Y
---
I
E
F
N
V
G
D
A
T
Q
F
K
S
---
E
D
E
F
G
F
I
I
T
N
P
P
Y
G
E
R
L
E
D
K
D
S
V
K
Q
L
Y
-------
K
E
L
-------------
G
Y
A
F
R
K
-
L
---
K
N
W
S
Y
Y
L
I
T
S
Y
E
D
--
F
E
Y
E
F
G
Q
K
A
D
K
K
R
K
L
Y
N
G
M
L
K
T
N
F
F
-
Q
Y
P
G
P
K
P
P
R
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
51.90
27%
-24
- C1 -
-
3LDG
1
?
A:
[2-380]
----
K
K
T
F
N
L
V
A
T
A
A
A
G
I
E
A
V
V
G
K
E
L
R
N
L
G
------
L
D
------
C
Q
V
----
E
---
N
G
R
V
L
F
K
G
-------------
N
-------------
I
E
T
I
A
K
S
N
L
W
L
R
S
A
D
R
I
K
I
V
V
G
E
F
P
A
-----------
R
-
T
F
E
E
L
F
Q
G
V
Y
A
L
D
W
E
N
Y
L
P
L
G
C
Q
F
P
V
--------
A
K
A
K
S
V
K
-
S
K
L
H
-
N
E
P
S
I
Q
G
I
T
K
K
A
I
V
K
K
L
Q
H
Y
F
H
R
P
D
S
VP
L
P
E
N
G
--
P
E
F
K
I
E
I
S
L
L
K
D
Q
A
R
V
M
I
D
T
T
G
-
P
-
S
L
F
K
R
G
Y
R
T
E
---
A
P
I
K
E
N
M
A
A
A
I
I
L
L
S
N
W
F
P
--
D
K
P
-
F
V
D
P
T
C
G
S
G
T
F
C
I
E
A
A
M
I
G
M
N
I
A
P
G
F
N
R
-
D
F
A
F
E
E
W
P
W
V
D
E
A
L
V
T
R
V
R
N
E
A
D
E
Q
A
D
Y
D
I
Q
---
L
D
I
S
G
F
D
F
D
G
R
M
V
E
I
A
R
K
N
A
R
E
V
G
L
E
D
V
---
V
K
L
K
Q
M
R
L
Q
D
F
K
T
---
N
K
I
N
G
V
L
I
S
N
P
P
Y
G
E
R
L
L
D
D
K
A
V
D
I
L
Y
-------
N
E
M
-------------
G
E
T
F
A
P
-
L
---
K
T
W
S
Q
F
I
L
T
N
D
T
D
--
F
E
Q
K
F
G
R
K
A
D
K
K
R
K
L
Y
N
G
S
L
K
V
D
L
Y
-
Q
F
Y
G
Q
R
V
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
50.27
31%
-28
- C1 -
-
3LDU
10
?
A:
[13-334]
-------------
C
F
F
G
M
E
K
M
L
A
R
E
I
T
N
L
G
------
Y
E
---
I
--
I
K
T
----
E
---
D
G
R
I
T
Y
K
T
-------------
D
-------------
E
F
G
I
A
K
S
N
M
W
L
R
C
A
E
R
V
H
L
K
I
A
E
F
E
A
K
--
S
-
F
---------
D
E
L
F
E
N
T
K
R
I
N
W
S
R
Y
I
P
Y
G
A
Q
F
P
I
--------
S
K
A
S
S
-
I
-
K
S
K
L
Y
S
T
P
D
V
Q
A
I
V
K
K
A
I
V
E
S
L
K
K
S
Y
L
E
D
G
L
--
L
K
E
D
K
--
E
K
Y
P
I
F
V
F
I
H
K
D
K
V
T
I
S
I
D
T
T
G
-
D
-
A
L
H
K
R
G
Y
R
E
K
--
K
A
P
I
R
E
T
L
A
A
G
L
I
Y
L
T
P
W
--
K
A
G
R
V
-
L
V
D
P
M
C
G
S
G
T
I
L
I
E
A
A
M
I
G
I
N
M
A
P
G
L
N
R
-
E
F
I
S
E
K
W
R
T
L
D
K
K
I
W
W
D
V
R
K
D
A
---
F
N
K
I
D
N
E
S
K
F
K
I
Y
G
Y
D
I
D
E
E
S
I
D
I
A
R
E
N
A
E
I
A
G
V
D
E
Y
I
------
E
F
N
V
G
D
A
T
Q
F
K
S
E
D
E
F
G
F
I
I
T
N
P
P
Y
G
E
R
L
E
D
K
D
S
V
K
Q
L
Y
-------
K
E
L
-------------
G
Y
A
F
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
48.36
24%
-33
- C1 -
-
3LDF
1
?
A:
[1-385]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
-------
L
M
V
-------------
G
S
F
A
E
K
-
K
--
L
K
R
G
V
Q
L
L
S
S
R
D
Y
P
--
N
L
N
----
L
D
N
Q
V
V
Q
L
Y
S
D
A
D
I
-
F
L
G
-
T
A
Y
L
S
K
Q
N
K
G
V
G
W
L
I
S
P
K
K
V
S
L
N
---
V
T
Y
F
I
K
L
F
Q
W
S
K
D
K
R
K
N
F
A
H
S
K
L
T
T
A
Y
R
L
F
N
Q
D
G
D
S
F
-
G
G
V
T
I
D
C
Y
G
D
F
V
L
F
S
W
Y
N
-------
S
F
V
Y
Q
I
R
D
E
I
V
A
A
F
R
Q
V
Y
P
-
N
F
L
G
A
Y
E
K
I
R
------
F
N
-
V
S
-
A
H
L
---
Y
G
Q
E
A
P
E
Q
F
L
I
L
E
N
G
I
S
Y
N
V
F
L
N
D
G
L
M
T
G
I
F
L
D
Q
R
Q
V
R
N
E
L
I
N
G
S
A
A
G
K
T
V
L
N
L
F
S
Y
T
A
A
F
S
V
A
A
A
M
G
G
A
M
A
T
T
S
V
D
L
A
K
R
S
R
A
L
S
L
A
H
F
E
A
N
H
L
D
M
A
N
H
Q
L
V
V
M
D
-
V
F
D
Y
F
K
Y
A
R
R
---
H
H
L
T
---
Y
D
I
I
I
I
D
P
P
S
F
A
R
N
K
E
---
V
F
S
V
S
K
D
Y
H
K
L
I
R
Q
G
L
E
I
L
S
E
N
G
L
I
I
A
S
T
N
A
A
N
M
---
T
V
S
-
Q
F
------
K
------
K
--
Q
I
-
E
K
G
F
GK
Q
K
H
T
Y
L
D
L
Q
Q
L
P
S
D
F
A
V
N
V
Q
D
E
S
SNY
L
K
V
-------
F
T
I
K
V
-----
31
Fugue
44.19
22%
7
- C1 -
-
3TM4
-
?
A:
[1-370]
-------
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
L
L
L
K
K
L
G
I
S
F
Q
---
I
--
E
E
K
----
P
LGI
E
G
R
L
L
L
E
A
E
K
A
Y
Y
V
D
EKG
R
K
R
E
-------------
L
S
I
S
T
Y
L
N
E
N
S
R
L
L
H
R
V
I
I
E
I
A
S
E
K
F
N
GI
E
-
K
-
D
-
E
S
E
E
A
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
--------
R
S
F
R
K
-
G
-
D
H
N
I
-
T
S
I
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
--
G
T
P
L
--
V
N
L
D
H
--
P
A
V
I
F
R
A
E
L
I
K
D
V
F
F
L
G
I
D
T
T
G
-
D
S
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
L
---
D
G
G
S
-
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
R
-------------------
R
Y
S
-----------------------
G
E
I
I
G
I
E
K
Y
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
V
L
D
K
---
I
K
F
I
Q
G
D
A
T
Q
L
S
Q
Y
--
V
D
S
V
D
F
A
I
S
N
L
P
Y
G
S
M
I
P
D
L
Y
--
M
K
F
F
-------
N
E
L
-------------
A
K
V
L
E
K
-
R
G
V
F
I
T
T
E
K
K
A
I
E
E
A
I
A
--
E
N
G
---
F
E
I
I
H
H
R
V
I
G
H
G
G
L
M
V
H
L
Y
-
V
V
K
L
E
H
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
44.17
27%
-14
- C1 -
-
3VSE
1
?
A:
[1-390]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
-------
A
T
L
-------------
N
K
G
K
E
T
-
K
--
Y
F
N
G
Y
P
L
I
E
E
E
D
I
Y
--
S
Q
D
H
L
--
K
E
G
D
I
F
Q
I
V
T
D
K
S
Q
Y
V
A
T
-
A
Y
V
G
R
Q
H
K
G
L
G
W
V
L
T
Y
D
K
A
Q
E
I
N
---
T
A
F
F
V
K
L
F
N
T
A
L
A
E
R
D
Y
Y
F
N
I
D
G
T
N
A
F
R
L
F
N
A
E
G
D
G
V
G
G
-
L
T
I
D
N
Y
D
G
H
L
L
I
Q
W
Y
-------
S
K
G
I
Y
K
F
K
Y
A
I
L
E
A
V
R
K
V
--
F
D
Y
K
S
I
Y
E
K
V
R
F
K
---
D
S
E
Y
S
G
-
G
F
V
---
E
G
D
A
P
E
F
P
I
V
I
E
E
N
F
T
F
Y
N
V
D
L
E
D
G
L
M
T
G
I
F
L
D
Q
K
E
V
R
K
K
L
R
G
Q
Y
A
K
E
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
A
A
-
S
E
A
S
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
L
N
A
I
D
----
P
K
S
Q
Y
I
Y
V
M
D
T
F
D
F
Y
K
Y
---
A
A
R
H
GHS
Y
D
T
I
V
I
D
P
P
S
F
A
R
N
K
K
--
R
T
F
S
V
Q
K
D
Y
D
K
L
I
N
G
A
L
N
I
L
S
S
E
G
T
L
L
L
C
T
N
A
S
V
Y
P
L
K
Q
F
K
-
N
T
------
I
------
K
--
K
T
-
L
E
E
S
G
V
D
Y
-
E
L
T
E
V
M
G
L
P
K
D
F
K
T
H
P
H
Y
K
P
-----
S
KY
L
K
A
V
F
V
N
I
R
H
-----
3
PsiBlast_PDB
42.36
29%
-14
- C1 -
-
3LDG
1
?
A:
[10-324]
------------
T
A
A
A
G
I
E
A
V
V
G
K
E
L
R
N
L
G
------
L
D
------
C
Q
V
----
E
---
N
G
R
V
L
F
K
G
-------------
N
-------------
I
E
T
I
A
K
S
N
L
W
L
R
S
A
D
R
I
K
I
V
V
G
E
F
P
-
A
--
R
-
T
-
F
-------
E
E
L
F
Q
G
V
Y
A
L
D
W
E
N
Y
L
P
L
G
C
Q
F
P
V
A
K
A
K
S
V
KS
K
L
H
N
E
-
P
-
S
I
Q
G
-
I
T
-------
K
K
A
I
V
K
K
L
Q
H
Y
F
H
R
P
D
S
--
V
P
L
P
E
N
G
P
E
F
K
I
E
I
S
L
L
K
D
Q
A
R
V
M
I
D
T
T
G
-
P
-
S
L
F
K
R
G
Y
R
T
E
---
A
P
I
K
E
N
M
A
A
A
I
I
L
L
S
N
W
F
P
D
K
P
---
F
V
D
P
T
C
G
S
G
T
F
C
I
E
A
A
M
I
G
M
N
I
A
P
G
F
N
R
-
D
F
A
F
E
E
W
P
W
V
D
E
A
L
V
T
R
V
R
N
E
A
D
E
Q
A
D
Y
D
I
Q
L
D
I
S
G
F
---
D
F
D
G
R
M
V
E
I
A
R
K
N
A
R
E
V
G
L
E
D
V
---
V
K
L
K
Q
M
R
L
Q
---
D
F
K
T
N
K
I
N
G
V
L
I
S
N
P
P
Y
G
E
R
L
L
D
D
K
A
V
D
I
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
42.35
22%
-10
- C1 -
-
3TM4
-
?
A:
[1-366]
-------
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
L
L
L
------
K
K
L
G
I
S
F
Q
I
E
E
KPLG
I
---
E
G
R
L
L
L
E
A
-------------
E
K
A
Y
Y
V
D
EKG
R
K
R
E
L
S
I
S
T
Y
L
N
E
N
S
R
L
L
H
R
V
I
I
E
I
A
S
E
K
F
N
--
G
I
E
K
D
E
S
E
E
-
A
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
--------
R
S
F
R
K
-
G
D
H
N
I
T
--
S
I
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
-
G
-
T
P
L
--
V
N
L
D
H
--
P
A
V
I
F
R
A
E
L
I
K
D
V
F
F
L
G
I
D
T
T
G
D
S
-
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
L
D
---
G
G
S
-
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
R
R
Y
S
------------------------------------------
G
E
I
I
G
I
E
K
Y
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
V
L
D
K
---
I
K
F
I
Q
G
D
A
T
Q
L
S
Q
Y
--
V
D
S
V
D
F
A
I
S
N
L
P
Y
G
------
S
M
I
P
D
L
Y
-------
M
K
F
-------------
F
N
E
L
A
K
V
L
--
E
K
R
G
V
F
I
T
T
E
K
K
A
I
E
E
A
I
A
E
N
G
F
E
I
I
H
H
R
V
I
G
H
G
G
L
M
V
H
L
Y
-
V
V
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
40.91
22%
-1
- C1 -
-
3TM5
1
?
B:
[1-366]
-------
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
L
L
L
------
K
K
LGI
S
FQ
I
E
E
KPLG
I
---
E
G
R
L
L
L
E
A
-------------
E
KAYYVDEKGRKRE
L
S
I
S
T
Y
L
N
E
N
S
R
L
L
H
R
V
I
I
E
I
A
S
E
K
F
N
--
G
I
E
K
D
E
S
E
E
-
A
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
--------
R
S
F
R
K
-
G
D
H
N
I
T
--
S
I
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
-
G
-
T
P
L
--
V
N
L
D
H
--
P
A
V
I
F
R
A
E
L
I
K
D
V
F
F
L
G
I
D
T
T
G
D
S
-
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
L
D
---
G
G
S
-
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
R
R
Y
S
------------------------------------------
G
E
I
I
G
I
E
K
Y
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
V
L
D
K
---
I
K
F
I
Q
G
D
A
T
Q
L
S
Q
Y
--
V
D
S
V
D
F
A
I
S
N
L
P
Y
G
L
K
I
G
K
K
S
M
I
P
D
L
Y
-------
M
K
F
-------------
F
N
E
L
A
K
V
L
--
E
K
R
G
V
F
I
T
T
E
K
K
A
I
EE
A
I
A
E
N
G
F
E
I
I
H
H
R
V
I
G
H
G
G
L
M
V
H
L
Y
-
V
V
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
40.87
22%
-1
- C1 -
-
3C0K
-
RLMI_ECOLI
A:
[76-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
F
F
S
R
R
L
Q
Q
A
Q
K
W
R
D
W
L
A
Q
K
D
G
L
D
S
Y
R
L
I
A
G
E
S
D
G
L
P
G
-
I
T
I
D
R
F
G
N
F
L
V
L
Q
L
L
S
A
G
A
-------
E
Y
Q
R
A
A
L
I
S
A
L
Q
T
L
Y
P
E
--
C
S
I
Y
D
R
S
D
V
A
V
R
K
K
E
G
-
M
E
-
L
T
Q
G
P
V
T
G
E
L
P
P
A
L
L
P
I
E
E
H
G
M
K
L
L
V
D
I
Q
H
G
H
K
T
G
Y
Y
L
D
Q
R
D
S
R
L
A
T
R
R
Y
-
V
E
N
K
R
V
L
N
C
F
S
Y
T
G
G
F
A
V
S
A
L
M
G
G
C
S
Q
V
V
S
V
D
T
S
Q
E
A
L
D
I
A
R
Q
N
V
E
L
N
K
L
D
----
L
S
K
A
E
F
V
R
D
D
V
F
K
L
L
R
T
Y
R
D
R
G
E
K
---
F
D
V
I
V
M
D
P
P
K
F
V
E
N
K
S
--
Q
L
M
G
A
C
R
G
Y
K
D
I
N
M
L
A
I
Q
L
L
N
E
G
G
I
L
L
T
F
S
C
S
G
L
M
---
T
S
D
-
L
F
------
Q
K
I
I
A
D
A
A
I
D
A
G
-
R
D
V
------
Q
F
I
E
Q
F
R
Q
A
A
D
H
P
V
I
A
T
Y
P
E
-----
G
-------
L
Y
--------
13
PsiBlast_PDB
40.45
23%
-67
- C1 -
-
3TMA
-
?
A:
[89-344]
--------------------------------------------------------------------------------------------------------------------------------
D
P
L
G
A
L
E
R
A
A
L
A
L
P
W
P
E
L
---
E
G
A
G
S
F
--------
R
V
E
A
R
-
R
-
E
--
G
-
E
H
P
F
T
S
P
E
V
E
R
R
V
G
E
A
L
H
R
A
Y
G
V
--
P
--
V
D
L
K
R
--
P
A
V
R
V
R
V
D
V
R
G
E
E
A
F
L
G
V
Q
L
T
E
-
R
-
P
L
S
R
R
-
F
P
K
A
A
L
R
G
S
L
T
P
V
L
A
Q
A
L
L
---
R
L
A
D
A
R
P
G
M
R
V
L
D
P
F
T
G
S
G
T
I
A
L
E
A
A
S
T
L
G
P
T
S
P
-----------------------------------------
V
Y
A
G
D
L
D
E
K
R
L
G
L
A
R
E
A
A
L
A
S
G
L
-
S
W
I
R
F
L
R
A
D
A
R
H
L
---
P
R
F
F
P
E
V
D
R
--
I
L
A
N
P
P
H
G
L
----
K
E
G
L
F
H
L
Y
W
D
F
L
R
G
A
L
A
L
LPPG
G
R
V
A
L
L
T
LR
P
A
L
L
K
R
-
A
--
L
P
P
G
F
A
L
R
H
A
R
V
V
E
--
Q
G
G
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
39.03
22%
-22
- C1 -
-
2B78
-
?
A:
[1-385]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
M
V
G
-------
S
F
A
-------------
E
K
K
L
K
R
-
G
--
V
Q
L
L
S
S
R
D
Y
P
N
L
N
L
--
D
N
Q
V
V
Q
L
Y
S
D
A
D
I
F
L
G
T
A
Y
L
S
K
Q
N
K
-
G
V
G
W
L
I
S
P
K
K
V
S
L
------------
N
V
T
Y
F
I
K
L
F
Q
W
S
K
D
K
R
K
N
F
A
H
S
K
L
T
T
A
Y
R
L
F
N
Q
D
G
D
S
F
-
G
G
V
T
I
D
C
Y
G
D
F
V
L
F
S
W
Y
N
S
F
V
Y
Q
I
R
D
E
I
V
A
A
F
R
Q
V
Y
P
N
F
L
G
A
Y
E
K
I
R
--------------
F
N
-
V
S
-
A
H
L
---
Y
G
Q
E
A
P
E
Q
F
L
I
L
E
N
G
I
S
Y
N
V
F
L
N
D
G
L
M
T
G
I
F
L
D
Q
R
Q
V
R
N
E
L
I
N
G
S
A
A
G
K
T
V
L
N
L
F
S
Y
T
A
A
F
S
V
A
A
A
M
G
G
A
M
A
T
T
S
V
D
L
A
K
R
S
R
A
L
S
L
A
H
F
E
A
N
H
L
D
M
A
N
H
Q
L
V
V
M
D
-
V
F
D
Y
F
K
Y
A
R
R
---
H
H
L
T
---
Y
D
I
I
I
I
D
P
P
S
F
E
V
F
-------
S
V
S
K
D
Y
H
K
L
I
R
Q
G
L
E
I
L
S
E
N
G
L
I
I
A
S
T
N
A
A
N
M
---
T
V
S
-
Q
F
------
K
------
K
--
Q
I
-
E
K
G
F
GKQ
K
H
T
Y
L
D
L
Q
Q
L
P
S
D
F
A
V
N
V
Q
D
E
S
-----
S
-------
N
Y
L
K
V
F
T
I
K
V
44
HHSearch
38.96
30%
-3
- C1 -
-
3VSE
1
?
B:
[74-381]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
F
F
V
K
L
F
N
T
A
L
A
E
R
D
Y
Y
F
N
I
D
G
T
N
A
F
R
L
F
N
A
E
G
D
G
V
G
G
-
L
T
I
D
N
Y
D
G
H
L
L
I
Q
W
Y
S
K
G
-------
I
Y
K
F
K
Y
A
I
L
E
A
V
R
K
V
F
D
--
Y
K
S
I
Y
E
K
V
R
F
---------
S
G
G
F
V
---
E
G
D
A
P
E
F
P
I
V
I
E
E
N
F
T
F
Y
N
V
D
L
E
D
G
L
M
T
G
I
F
L
D
Q
K
E
V
R
K
K
L
R
G
Q
Y
A
K
E
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
A
A
S
-
E
A
S
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
L
N
A
I
D
----
P
K
S
Q
Y
I
Y
V
M
D
T
F
D
F
Y
K
Y
A
A
R
H
G
H
S
---
Y
D
T
I
V
I
D
P
P
S
F
A
R
N
K
K
--
R
T
F
S
V
Q
K
D
Y
D
K
L
I
N
G
A
L
N
I
L
S
S
E
G
T
L
L
L
C
T
N
A
S
V
Y
---
P
L
K
-
Q
F
K
N
T
I
K
K
T
------
L
E
E
S
G
-
V
D
Y
------
E
L
T
E
V
M
G
L
P
K
D
F
K
T
H
P
H
Y
K
P
-----
S
-------
K
Y
L
-------