@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLH3: (2017-11-02 )
MSIVKIENVRVLDPIQKTDSVQTVYLQDGKLVAPVDQVEQTIDGQGKWLMPTMVDLCARLREPGQQQHGTLKSEGKAARANGILHVITPPDSKPIVQDNGALIHGLIEKAWHDGGIHMHIIGAQTHGLNGKQPANMAGLKKGGCTAVSNANAAFENDDVVVRTLEYAAGLGLTVVFYAEEPQLAKDGCAHEGFIASRQGLPMIPAIAETVAIAKHLLMIEATGVKAHFGLLSCGASVELIRAAKAKGLPVTADVAMHQLHLTEQLIDGFNSLAHVRPPLRSAQDKELLRQGLKQGVIDAICTHHEPLSSSAKMAPFAETQPGITAFDTYVALGIQLINEGLFEPLEWVTKVTSAPAQVANMTARWQAEAGWVLVDPELSWTVSKDTILSQGKNTPLLGQKLTGKVLQTFAV
Atome Classification :
(20 SA)
....-.....10........20........30..-------..-.-----.-----..----40........50........60..--..--....70........80......--..90..-......100......------.110.......120.......130.......140.....---..---.---150-.........160.......170.......180---------.....---.---.190-.........200........210....------...220-----........230.......240.......250.......260.....----.----.270....----...280.......290.......300.......310---.---.---.....320.....-.-.330....-....340.......350........360--.--.---.-----.-----...---.370--........380.......390.......400.......410-----------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
I
V
-
K
I
E
N
V
R
V
LDPIQKTDS
V
Q
T
V
Y
LQDG
K
L
VA-------
P
V
-
D
-----
Q
-----
V
E
----
Q
T
IDGQGKWL
M
P
T
M
V
D
L
C
A
R
LREP--GQ--QQHGTLKSEGKAARAN
G
I
L
H
V
I--TPPDSK-
P
I
VQDN
G
A
L
I
H
G
L
I
E
------
K
A
WHDG
G
I
H
M
H
I
I
GAQTHGLNGKQPA
N
M
A
GLK-KGG
C
T
A---VS---N---A---NAAFEND
D
V
V
V
R
T
L
E
Y
AAGL
G
L
T
V
V
F
YAEEPQ---------LAKDG---C---AH---EGFIASRQGL-PM
I
P
A
I
A
E
T
V
A
I
A
K
H
L
------
L
M
I
E
A------TGV
K
A
H
F
G
L
LSCGAS
V
E
L
I
R
AAKAKGLPV
T
A
D
V
A
M
H
Q
L
H
L
T
E
Q
L
I
D
----
G
----
F
N
S
L
A
HVR----PPLRS
A
Q
D
K
E
L
L
R
Q
G
L
K
Q
G
V
I
D
A
I
CTHHEPLSSSAK---M---A---PFAETQPG
I
T
A
F
D
-
T
-
Y
V
-
A
L
G
I
Q
-
L
I
N
E
GLF
E
P
L
E
W
V
T
K
V
-TSA
P
A
Q
V
A
N
M
---
T
--
A
---
R
-----
W
-----QAE---A
G
W
---
V
L
VDPE
L
S
W
T
VSK
D
T
I
LSQGKNTPLL
G
Q
K
L
T
G
K
V
L
Q
T
FAV------------------------------------------------
48
HHSearch
72.09
29%
21
* C2 *
-
4YIW
1
PYRC_BACAN
B:
[24-438]
--
M
N
Y
L
F
K
N
G
R
Y
M
N
E
E
G
-
K
I
V
A
T
D
L
L
V
Q
D
G
K
I
A
K
-------
V
A
E
N
I
T
A
--
D
-----
N
A
----
E
V
I
D
V
N
G
K
L
I
A
P
G
L
V
D
V
H
V
H
L
R
E
P
--
G
G
--
E
H
K
E
T
I
E
T
G
T
L
A
A
A
K
G
G
F
T
T
I
C
--
A
M
P
N
T
R
-
P
V
P
D
C
R
-
E
H
M
E
D
L
Q
N
------
R
I
K
E
K
A
H
V
N
V
L
P
Y
G
A
I
T
V
R
Q
A
G
S
E
M
T
D
F
E
T
L
K
-
E
L
G
A
F
A
---
F
T
---
D
---
D
---
G
V
G
V
Q
D
A
S
M
M
L
A
A
M
K
R
A
A
K
L
N
M
A
V
V
A
H
C
E
E
N
T
---------
L
I
N
K
G
---
C
---
V
H
---
E
G
K
F
S
E
K
H
G
L
-
N
G
I
P
S
V
C
E
S
V
H
I
A
R
D
I
------
L
L
A
E
A
------
A
D
C
H
Y
H
V
C
H
V
S
T
K
G
S
V
R
V
I
R
D
A
K
R
A
G
I
K
V
T
A
E
V
T
P
H
H
L
V
L
C
E
D
D
I
P
----
S
----
A
D
P
N
F
K
M
N
----
P
P
L
R
G
K
E
D
H
E
A
L
I
E
G
L
L
D
G
T
I
D
M
I
A
T
D
H
A
P
H
T
A
E
E
K
---
A
---
Q
---
G
I
E
R
A
P
F
G
I
T
G
F
E
-
T
-
A
F
-
P
L
L
Y
T
N
L
V
K
K
G
I
I
T
L
E
Q
L
I
Q
F
L
-
T
E
K
P
A
D
T
F
G
L
---
E
--
A
---
G
RLK--
E
-----
G
R
T
---
A
D
I
---
T
I
I
D
L
E
Q
E
E
E
I
D
P
T
T
F
L
S
K
G
K
N
T
P
F
A
G
W
K
C
Q
G
W
P
V
M
T
I
V
-------------------------------------------------
34
HHSearch
70.93
28%
13
- C2 -
-
3GRI
-
PYRC_STAAC
B:
[3-414]
-----
L
I
K
N
G
K
V
L
Q
N
G
--
E
L
Q
Q
A
D
I
L
I
D
G
K
V
I
K
Q
-------
I
A
P
A
IEPS-
N
-----
G
V
----
D
I
I
D
A
K
G
H
F
V
S
P
G
F
V
D
V
H
V
H
L
R
E
P
--
G
G
--
E
Y
K
E
T
I
E
T
G
T
K
A
A
A
R
G
G
F
T
T
V
C
--
P
M
P
N
T
R
-
P
V
P
D
S
V
-
E
H
F
E
A
L
Q
K
------
L
I
D
D
N
A
Q
V
R
V
L
P
Y
A
S
I
T
T
R
Q
L
G
K
E
L
V
D
F
P
A
L
V
-
K
E
G
A
F
A
---
F
T
---
D
---
D
---
G
V
G
V
Q
T
A
S
M
M
Y
E
G
M
I
E
A
A
K
V
N
K
A
I
V
A
H
C
E
D
N
S
---------
L
I
Y
G
G
---
A
---
M
H
---
E
G
K
R
S
K
E
L
G
I
-
P
G
I
P
N
I
C
E
S
V
Q
I
A
R
D
V
------
L
L
A
E
A
------
A
G
C
H
Y
H
V
C
H
V
S
T
K
E
S
V
R
V
I
R
D
A
K
R
A
G
I
H
V
T
A
E
V
T
P
H
H
L
L
L
T
E
D
D
I
P
----
G
----
N
N
A
I
Y
K
M
N
----
P
P
L
R
S
T
E
D
R
E
A
L
L
E
G
L
L
D
G
T
I
D
C
I
A
T
D
H
A
P
H
A
R
D
E
K
---
A
---
Q
---
P
M
E
K
A
P
F
G
I
V
G
S
E
-
T
-
A
F
-
P
L
L
Y
T
H
F
V
K
N
G
D
W
T
L
Q
Q
L
V
D
Y
L
-
T
I
K
P
C
E
T
F
N
L
---
E
--
Y
---
G
TLK--
E
-----
N
G
Y
---
A
D
L
---
T
I
I
D
L
D
S
E
Q
E
I
K
G
E
D
F
L
S
K
A
D
N
T
P
F
I
G
Y
K
V
Y
G
N
P
I
L
T
M
V
-------------------------------------------------
6
PsiBlast_PDB
70.21
30%
9
- C2 -
-
4YIW
1
PYRC_BACAN
A:
[45-431]
------------------------
L
L
V
Q
D
G
K
I
A
K
-------
V
A
-
E
-----
N
-----
I
T
ADN
A
E
V
I
D
V
N
G
K
L
I
A
P
G
L
V
D
V
H
V
H
L
R
E
P
--
G
G
--
E
H
K
E
T
I
E
T
G
T
L
A
A
A
K
G
G
F
T
T
I
C
--
A
M
P
N
T
R
-
P
-
V
P
D
C
R
E
H
M
E
D
L
Q
N
------
R
I
K
E
K
A
H
V
N
V
L
P
Y
G
A
I
T
V
R
Q
A
G
S
E
M
T
D
F
E
T
L
K
-
E
L
G
A
F
A
---
F
T
---
D
---
D
---
G
V
G
V
Q
D
A
S
M
M
L
A
A
M
K
R
A
A
K
L
N
M
A
V
V
A
H
C
E
E
N
T
---------
L
I
N
K
G
---
C
---
V
H
---
E
G
K
F
S
E
K
H
G
L
-
N
G
I
P
S
V
C
E
S
V
H
I
A
R
D
I
------
L
L
A
E
A
------
A
D
C
H
Y
H
V
C
H
V
S
T
K
G
S
V
R
V
I
R
D
A
K
R
A
G
I
K
V
T
A
E
V
T
P
H
H
L
V
L
C
E
D
D
I
P
----
S
----
A
D
P
N
F
K
M
N
----
P
P
L
R
G
K
E
D
H
E
A
L
I
E
G
L
L
D
G
T
I
D
M
I
A
T
D
H
A
P
H
T
A
E
E
K
---
A
---
Q
---
G
I
E
R
A
P
F
G
I
T
G
F
E
-
T
A
F
P
-
L
L
Y
T
N
-
L
V
K
K
G
I
I
T
L
E
Q
L
I
Q
F
L
-
T
E
K
P
A
D
T
F
G
L
---
E
--
A
---
G
-----
R
-----
L
K
E
GRT
A
D
I
---
T
I
I
D
L
E
Q
E
E
E
I
D
P
T
T
F
L
S
K
G
K
N
T
P
F
A
G
W
K
C
Q
G
--------------------------------------------------------
33
HHSearch
69.89
28%
13
- C2 -
-
3GRI
-
PYRC_STAAC
A:
[3-414]
-----
L
I
K
N
G
K
V
L
Q
N
G
--
E
L
Q
Q
A
D
I
L
I
D
G
K
V
I
K
Q
-------
I
A
P
A
I
E
P
S
-
N
-----
G
V
----
D
I
I
D
A
K
G
H
F
V
S
P
G
F
V
D
V
H
V
H
L
R
E
P
--
G
G
--
E
Y
K
E
T
I
E
T
G
T
K
A
A
A
R
G
G
F
T
T
V
C
--
P
M
P
N
T
R
-
P
V
P
D
S
V
-
E
H
F
E
A
L
Q
K
------
L
I
D
D
N
A
Q
V
R
V
L
P
Y
A
S
I
T
T
R
Q
L
G
K
E
L
V
D
F
P
A
L
V
-
K
E
G
A
F
A
---
F
T
---
D
---
D
---
G
V
G
V
Q
T
A
S
M
M
Y
E
G
M
I
E
A
A
K
V
N
K
A
I
V
A
H
C
E
D
N
S
---------
L
I
Y
G
G
---
A
---
M
H
---
E
G
K
R
S
K
E
L
G
I
-
P
G
I
P
N
I
C
E
S
V
Q
I
A
R
D
V
------
L
L
A
E
A
------
A
G
C
H
Y
H
V
C
H
V
S
T
K
E
S
V
R
V
I
R
D
A
K
R
A
G
I
H
V
T
A
E
V
T
P
H
H
L
L
L
T
E
D
D
I
P
----
G
----
N
N
A
I
Y
K
M
N
----
P
P
L
R
S
T
E
D
R
E
A
L
L
E
G
L
L
D
G
T
I
D
C
I
A
T
D
H
A
P
H
A
R
D
E
K
---
A
---
Q
---
P
M
E
K
A
P
F
G
I
V
G
S
E
-
T
-
A
F
-
P
L
L
Y
T
H
F
V
K
N
G
D
W
T
L
Q
Q
L
V
D
Y
L
-
T
I
K
P
C
E
T
F
N
L
---
E
--
Y
---
G
TLK--
E
-----
N
G
Y
---
A
D
L
---
T
I
I
D
L
D
S
E
Q
E
I
K
G
E
D
F
L
S
K
A
D
N
T
P
F
I
G
Y
K
V
Y
G
N
P
I
L
T
M
V
-------------------------------------------------
4
PsiBlast_PDB
69.48
28%
18
- C2 -
-
4BJH
5
PYRC_AQUAE
A:
[40-447]
------
V
K
N
G
Y
V
I
D
P
S
Q
N
L
E
G
E
F
D
I
L
V
E
N
G
K
-
I
K
-------
K
I
-
D
-----
K
N
I
L
V
P
E
A
----
E
I
I
D
A
K
G
L
I
V
C
P
G
F
I
D
I
H
V
H
L
R
D
P
--
G
Q
--
T
Y
K
E
D
I
E
S
G
S
R
C
A
V
A
G
G
F
T
T
I
V
--
C
M
P
N
T
N
-
P
P
I
-
D
N
T
T
V
V
N
Y
I
L
Q
------
K
S
K
S
V
G
L
C
R
V
L
P
T
G
T
I
T
K
G
R
K
G
K
E
I
A
D
F
Y
S
L
K
-
E
A
G
C
V
A
---
F
T
---
D
---
D
---
G
S
P
V
M
D
S
S
V
M
R
K
A
L
E
L
A
S
Q
L
G
V
P
I
M
D
A
C
E
D
D
K
---------
L
A
Y
-
G
---
V
---
I
N
---
E
G
E
V
S
A
L
L
G
L
-
S
S
R
A
P
E
A
E
E
I
Q
I
A
R
D
G
------
I
L
A
Q
R
------
T
G
G
H
V
H
I
Q
A
V
S
T
K
L
S
L
E
I
I
E
F
F
K
E
K
G
V
K
I
T
C
E
V
N
P
N
H
L
L
F
T
E
R
E
V
L
----
N
----
S
G
A
N
A
R
V
N
----
P
P
L
R
K
K
E
D
R
L
A
L
I
E
G
V
K
R
G
I
I
D
C
F
A
T
D
H
A
P
H
Q
T
F
E
K
E--
L
---
V
---
E
F
A
--
M
P
G
I
I
G
L
Q
-
T
-
A
L
-
P
S
A
L
E
-
L
Y
R
K
G
I
I
S
L
K
K
L
I
E
M
F
-
T
I
N
P
A
R
I
I
G
V
DLG
T
--
L
---
K
-----
L
-----
G
S
P
---
A
D
I
---
T
I
F
D
P
N
K
E
W
I
L
N
E
E
T
N
L
S
K
S
R
N
T
P
L
W
G
K
V
L
K
G
K
V
I
Y
T
I
--------------------------------------------------
5
PsiBlast_PDB
69.35
30%
13
- C2 -
-
3MPG
-
PYRC_BACAN
A:
[22-408]
------------------------
L
L
V
Q
D
G
K
I
A
K
-------
V
A
-
E
-----
N
-----
I
T
ADNA
E
V
I
D
V
N
G
K
L
I
A
P
G
L
V
D
V
H
V
H
L
R
E
P
--
G
G
--
E
H
K
E
T
I
E
T
G
T
L
A
A
A
K
G
G
F
T
T
I
C
--
A
M
P
N
T
R
-
P
-
V
P
D
C
R
E
H
M
E
D
L
Q
N
------
R
I
K
E
K
A
H
V
N
V
L
P
Y
G
A
I
T
V
R
Q
A
G
S
E
M
T
D
F
E
T
L
K
-
E
L
G
A
F
A
---
F
T
---
D
---
D
---
G
V
G
V
Q
D
A
S
M
M
L
A
A
M
K
R
A
A
K
L
N
M
A
V
V
A
H
C
E
E
N
T
---------
L
I
N
K
G
---
C
---
V
H
---
E
G
K
F
S
E
K
H
G
L
-
N
G
I
P
S
V
C
E
S
V
H
I
A
R
D
I
------
L
L
A
E
A
------
A
D
C
H
Y
H
V
C
H
V
S
T
K
G
S
V
R
V
I
R
D
A
K
R
A
G
I
K
V
T
A
E
V
T
P
H
H
L
V
L
C
E
D
D
I
P
----
S
----
A
D
P
N
F
K
M
N
----
P
P
L
R
G
K
E
D
H
E
A
L
I
E
G
L
L
D
G
T
I
D
M
I
A
T
D
H
A
P
H
T
A
E
E
K
---
A
---
Q
---
G
I
E
R
A
P
F
G
I
T
G
F
E
-
T
A
F
P
-
L
L
Y
T
N
-
L
V
K
K
G
I
I
T
L
E
Q
L
I
Q
F
L
-
T
E
K
P
A
D
T
F
G
L
---
E
--
A
---
G
-----
R
-----
L
K
E
GRT
A
D
I
---
T
I
I
D
L
E
Q
E
E
E
I
D
P
T
T
F
L
S
K
G
K
N
T
P
F
A
G
W
K
C
Q
G
--------------------------------------------------------
50
HHSearch
69.23
29%
31
- C2 -
-
3MPG
-
PYRC_BACAN
A:
[2-415]
---
N
Y
L
F
K
N
G
R
Y
M
N
E
E
G
-
K
I
V
A
T
D
L
L
V
Q
D
G
K
I
A
K
-------
V
A
E
N
ITA--
D
-----
N
A
----
E
V
I
D
V
N
G
K
L
I
A
P
G
L
V
D
V
H
V
H
L
R
E
P
--
G
G
--
E
H
K
E
T
I
E
T
G
T
L
A
A
A
K
G
G
F
T
T
I
C
--
A
M
P
N
T
R
-
P
V
P
D
C
R
-
E
H
M
E
D
L
Q
N
------
R
I
K
E
K
A
H
V
N
V
L
P
Y
G
A
I
T
V
R
Q
A
G
S
E
M
T
D
F
E
T
L
K
-
E
L
G
A
F
A
---
F
T
---
D
---
D
---
G
V
G
V
Q
D
A
S
M
M
L
A
A
M
K
R
A
A
K
L
N
M
A
V
V
A
H
C
E
E
N
T
---------
L
I
N
K
G
---
C
---
V
H
---
E
G
K
F
-
S
E
K
H
G
L
N
G
I
P
S
V
C
E
S
V
H
I
A
R
D
I
------
L
L
A
E
A
------
A
D
C
H
Y
H
V
C
H
V
S
T
K
G
S
V
R
V
I
R
D
A
K
R
A
G
I
K
V
T
A
E
V
T
P
H
H
L
V
L
C
E
D
D
I
P
----
S
----
A
D
P
N
F
K
M
N
----
P
P
L
R
G
K
E
D
H
E
A
L
I
E
G
L
L
D
G
T
I
D
M
I
A
T
D
H
A
P
H
T
A
E
E
K
---
A
---
Q
---
G
I
E
R
A
P
F
G
I
T
G
F
E
-
T
-
A
F
-
P
L
L
Y
T
N
L
V
K
K
G
I
I
T
L
E
Q
L
I
Q
F
L
-
T
E
K
P
A
D
T
F
G
L
---
E
--
A
---
G
RLK--
E
-----
G
R
T
---
A
D
I
---
T
I
I
D
L
E
Q
E
E
E
I
D
P
T
T
F
L
S
K
G
K
N
T
P
F
A
G
W
K
C
Q
G
W
P
V
M
T
I
V
-------------------------------------------------
1
PsiBlast_PDB
69.18
28%
21
- C2 -
-
3D6N
-
PYRC_AQUAE
A:
[6-413]
------
V
K
N
G
Y
V
I
D
P
S
Q
N
L
E
G
E
F
D
I
L
V
E
N
G
K
-
I
K
-------
K
I
-
D
-----
K
NILVP
E
A
----
E
I
I
D
A
K
G
L
I
V
C
P
G
F
I
D
I
H
V
H
L
R
D
P
--
G
Q
--
T
Y
K
E
D
I
E
S
G
S
R
C
A
V
A
G
G
F
T
T
I
V
--
C
M
P
N
T
N
-
P
P
I
-
D
N
T
T
V
V
N
Y
I
L
Q
------
K
S
K
S
V
G
L
C
R
V
L
P
T
G
T
I
T
K
G
R
K
G
K
E
I
A
D
F
Y
S
L
K
-
E
A
G
C
V
A
---
F
T
---
D
---
D
---
G
S
P
V
M
D
S
S
V
M
R
K
A
L
E
L
A
S
Q
L
G
V
P
I
M
D
H
C
E
D
D
K
---------
L
A
Y
-
G
---
V
---
I
N
---
E
G
E
V
S
A
L
L
G
L
-
S
S
R
A
P
E
A
E
E
I
Q
I
A
R
D
G
------
I
L
A
Q
R
------
T
G
G
H
V
H
I
Q
H
V
S
T
K
L
S
L
E
I
I
E
F
F
K
E
K
G
V
K
I
T
C
E
V
N
P
N
H
L
L
F
T
E
R
E
V
L
----
N
----
S
G
A
N
A
R
V
N
----
P
P
L
R
K
K
E
D
R
L
A
L
I
E
G
V
K
R
G
I
I
D
C
F
A
T
D
H
A
P
H
Q
T
F
E
K
E--
L
---
V
---
E
F
A
--
M
P
G
I
I
G
L
Q
-
T
-
A
L
-
P
S
A
L
E
-
L
Y
R
K
G
I
I
S
L
K
K
L
I
E
M
F
-
T
I
N
P
A
R
I
I
G
V
DLG
T
--
L
---
K
-----
L
-----
G
S
P
---
A
D
I
---
T
I
F
D
P
N
K
E
W
I
L
N
E
E
T
N
L
S
K
S
R
N
T
P
L
W
G
K
V
L
K
G
K
V
I
Y
T
I
--------------------------------------------------
49
HHSearch
68.75
32%
21
- C2 -
-
2Z00
-
PYRC_THET8
A:
[3-416]
-----
L
I
R
N
V
R
L
V
D
A
R
G
-
E
R
G
P
A
D
V
L
I
G
E
G
R
I
L
S
-------
L
E
G
G
-----
E
-----
A
K
----
Q
V
V
D
G
T
G
C
F
L
A
P
G
F
L
D
L
H
A
H
L
R
E
P
--
G
E
--
E
V
K
E
D
L
F
S
G
L
L
A
A
V
R
G
G
Y
T
D
L
V
--
S
M
P
N
T
K
-
P
P
V
D
T
P
-
E
A
V
R
A
L
K
E
------
K
A
K
A
L
G
L
A
R
L
H
P
A
A
A
L
T
E
K
Q
E
G
K
T
-
L
T
P
A
G
L
L
R
E
A
G
A
V
L
---
L
T
---
D
---
D
---
G
R
T
N
E
D
A
G
V
L
A
A
G
L
L
M
A
A
P
L
G
L
P
V
A
V
H
A
E
D
A
G
---------
L
R
R
N
G
---
V
---
M
N
---
D
G
P
L
A
D
L
L
G
L
-
P
G
N
P
P
E
A
E
A
A
R
I
A
R
D
L
------
E
V
L
R
Y
A
L
R
R
SP
A
T
P
R
L
H
V
Q
H
L
S
T
K
R
G
L
E
L
V
R
E
A
K
R
A
G
L
P
V
T
A
E
A
T
P
H
H
L
T
L
T
E
E
A
L
R
----
T
----
F
D
P
L
F
K
V
A
----
P
P
L
R
G
E
E
D
R
E
A
L
L
E
G
L
L
D
G
T
L
D
A
I
A
T
D
H
A
P
H
T
L
A
E
K
---
E
---
K
---
D
L
L
R
A
P
F
G
I
P
S
L
E
-
V
-
A
F
-
P
L
L
Y
T
E
L
H
L
K
R
G
F
P
L
Q
R
L
V
E
L
F
-
T
D
G
P
R
R
V
L
G
L
---
P
--
P
---
L
H
LE--
E
-----
G
A
E
---
A
S
L
---
V
L
L
S
P
K
E
-
R
P
V
D
P
S
A
F
A
S
K
A
R
Y
S
P
W
A
G
W
V
L
G
G
W
P
V
L
T
L
V
-------------------------------------------------
60
HHSearch
67.76
27%
34
- C2 -
-
3D6N
-
PYRC_AQUAE
A:
[2-414]
--
L
K
L
I
V
K
N
G
Y
V
I
D
P
S
Q
N
L
E
G
E
F
D
I
L
V
E
N
G
K
I
K
K
-------
I
D
K
N
ILV--
P
-----
E
A
----
E
I
I
D
A
K
G
L
I
V
C
P
G
F
I
D
I
H
V
H
L
R
D
P
--
G
Q
--
T
Y
K
E
D
I
E
S
G
S
R
C
A
V
A
G
G
F
T
T
I
V
--
C
M
P
N
T
N
-
P
P
I
D
N
T
-
T
V
V
N
Y
I
L
Q
------
K
S
K
S
V
G
L
C
R
V
L
P
T
G
T
I
T
K
G
R
K
G
K
E
I
A
D
F
Y
S
L
K
-
E
A
G
C
V
A
---
F
T
---
D
---
D
---
G
S
P
V
M
D
S
S
V
M
R
K
A
L
E
L
A
S
Q
L
G
V
P
I
M
D
H
C
E
D
D
K
---------
L
A
Y
G
V
-------
I
N
---
E
G
E
V
S
A
L
L
G
L
-
S
S
R
A
P
E
A
E
E
I
Q
I
A
R
D
G
------
I
L
A
Q
R
------
T
G
G
H
V
H
I
Q
H
V
S
T
K
L
S
L
E
I
I
E
F
F
K
E
K
G
V
K
I
T
C
E
V
N
P
N
H
L
L
F
T
E
R
E
V
L
----
N
----
S
G
A
N
A
R
V
N
----
P
P
L
R
K
K
E
D
R
L
A
L
I
E
G
V
K
R
G
I
I
D
C
F
A
T
D
H
A
P
H
Q
T
F
E
K
---
E
-------
L
V
E
F
A
M
P
G
I
I
G
L
Q
-
T
-
A
L
-
P
S
A
L
E
-
L
Y
R
K
G
I
I
S
L
K
K
L
I
E
M
F
-
T
I
N
P
A
R
I
I
G
V
---
D
--
L
---
G
TLK--
L
-----
G
S
P
---
A
D
I
---
T
I
F
D
P
N
K
E
W
I
L
N
E
E
T
N
L
S
K
S
R
N
T
P
L
W
G
K
V
L
K
G
K
V
I
Y
T
I
K
-------------------------------------------------
7
PsiBlast_PDB
67.36
29%
35
- C2 -
-
3GRI
-
PYRC_STAAC
A:
[4-412]
------
I
K
N
G
K
V
L
---
Q
N
G
E
L
Q
Q
A
D
I
L
I
D
G
K
V
I
K
QIAP
A
I
E
P
S
-
N
-----
G
-----
V
D
-----
I
I
D
A
K
G
H
F
V
S
P
G
F
V
D
V
H
V
H
L
R
E
P
--
G
G
--
E
Y
K
E
T
I
E
T
G
T
K
A
A
A
R
G
G
F
T
T
V
C
--
P
M
P
N
T
R
-
P
-
V
P
D
S
V
E
H
F
E
A
L
Q
K
------
L
I
D
D
N
A
Q
V
R
V
L
P
Y
A
S
I
T
T
R
Q
L
G
K
E
L
V
D
F
P
A
L
V
-
K
E
G
A
F
A
---
F
T
---
D
---
D
---
G
V
G
V
Q
T
A
S
M
M
Y
E
G
M
I
E
A
A
K
V
N
K
A
I
V
A
H
C
E
D
N
S
---------
L
I
Y
G
G
---
A
---
M
H
---
E
G
K
R
S
K
E
L
G
I
-
P
G
I
P
N
I
C
E
S
V
Q
I
A
R
D
V
------
L
L
A
E
A
------
A
G
C
H
Y
H
V
C
H
V
S
T
K
E
S
V
R
V
I
R
D
A
K
R
A
G
I
H
V
T
A
E
V
T
P
H
H
L
L
L
T
E
D
D
I
P
----
G
----
N
N
A
I
Y
K
M
N
----
P
P
L
R
S
T
E
D
R
E
A
L
L
E
G
L
L
D
G
T
I
D
C
I
A
T
D
H
A
P
H
A
R
D
E
K
---
A
---
Q
---
P
M
E
K
A
P
F
G
I
V
G
S
E
-
T
A
F
P
-
L
L
Y
T
H
-
F
V
K
N
G
D
W
T
L
Q
Q
L
V
D
Y
L
-
T
I
K
P
C
E
T
F
N
L
---
E
--
Y
---
G
-----
T
-----
L
K
E
---
N
G
Y
AD
L
T
I
I
D
L
D
S
E
Q
E
I
K
G
E
D
F
L
S
K
A
D
N
T
P
F
I
G
Y
K
V
Y
G
N
P
I
L
T
---------------------------------------------------
9
PsiBlast_PDB
67.02
27%
-102
- C2 -
-
4C6B
6
A:
[11-340]
------------------------------------------------------------------------
L
P
G
L
I
D
V
H
V
H
L
R
-----------
E
D
F
A
S
G
T
A
A
A
L
A
G
G
I
T
M
V
C
--
A
M
P
N
T
R
-
P
P
I
I
D
A
P
A
L
--
A
L
A
Q
------
K
L
A
E
A
G
A
----------------------------
R
C
D
F
---
A
L
---
F
---
L
---
G
A
S
S
E
N
A
G
T
L
G
T
V
A
G
S
A
A
G
L
K
L
Y
L
N
E
T
F
S
E
L
R
---------
L
D
S
V
V
---
Q
---
W
M
---
E
H
F
E
T
W
P
S
H
L
-
P
I
V
-
A
H
A
E
Q
Q
T
V
A
A
V
L
------
M
V
A
Q
L
------
T
Q
R
S
V
H
I
C
H
V
A
R
K
E
E
I
L
L
I
K
A
A
K
A
R
G
L
P
V
T
C
E
V
A
P
H
H
L
F
L
S
H
D
D
---------------
G
E
V
R
----
P
E
L
G
S
R
Q
D
V
E
A
L
W
E
N
M
--
A
V
I
D
C
F
A
S
D
H
A
P
H
T
L
E
E
K
---
C
----------
R
P
P
P
G
F
P
G
L
E
-
T
-
M
L
-
P
L
L
L
T
-
A
V
S
E
G
R
L
S
L
D
D
L
L
Q
R
L
-
H
H
N
P
R
R
I
F
H
L
---
P
--
P
---
Q
-------------
E
---
D
T
Y
---
V
E
V
D
L
E
H
E
W
T
I
P
S
H
M
P
F
S
K
A
H
W
T
P
F
E
G
Q
K
V
K
G
T
V
------------------------------------------------------
8
PsiBlast_PDB
66.05
30%
32
- C2 -
-
2Z00
-
PYRC_THET8
A:
[2-409]
---
I
-
L
I
R
N
V
R
L
V
D
-
A
R
G
E
R
G
P
A
D
V
L
I
G
E
G
R
I
L
S
L------
E
G
-
G
-----
E
-----
A
K
----
Q
V
V
D
G
T
G
C
F
L
A
P
G
F
L
D
L
H
A
H
L
R
E
P
--
G
E
--
E
V
K
E
D
L
F
S
G
L
L
A
A
V
R
G
G
Y
T
D
L
V
--
S
M
P
N
T
K
-
P
P
V
-
D
T
P
E
A
V
R
A
L
K
E
------
K
A
K
A
L
G
L
A
R
L
H
P
A
A
A
L
T
E
K
Q
E
G
K
T
L
T
P
A
G
L
L
R
-
E
A
G
A
V
L
---
L
T
---
D
---
D
---
G
R
T
N
E
D
A
G
V
L
A
A
G
L
L
M
A
A
P
L
G
L
P
V
A
V
H
A
E
D
A
G
---------
L
R
R
N
G
---
V
---
M
N
---
D
G
P
L
A
D
L
L
G
L
-
P
G
N
P
P
E
A
E
A
A
R
I
A
R
D
L
E
V
L
R
Y
A
L
R
R
S
P
------
A
T
P
R
L
H
V
Q
H
L
S
T
K
R
G
L
E
L
V
R
E
A
K
R
A
G
L
P
V
T
A
E
A
T
P
H
H
L
T
L
T
E
E
A
L
R
----
T
----
F
D
P
L
F
K
V
A
----
P
P
L
R
G
E
E
D
R
E
A
L
L
E
G
L
L
D
G
T
L
D
A
I
A
T
D
H
A
P
H
T
L
A
E
K
---
E
---
K
---
D
L
L
R
A
P
F
G
I
P
S
L
E
-
V
-
A
F
-
P
L
L
Y
T
-
E
L
H
L
K
R
G
F
P
L
Q
R
L
V
E
L
F
T
D
G
P
R
R
V
L
G
L
---
P
--
P
L
H
L
E
-----
E
-----
G
A
E
---
A
S
L
---
V
L
L
S
P
K
-
E
R
P
V
D
P
S
A
F
A
S
K
A
R
Y
S
P
W
A
G
W
V
L
G
G
--------------------------------------------------------
67
Fugue
65.12
25%
14
- C2 -
-
4TQT
6
?
A:
[14-490]
A
S
K
V
--
I
K
G
G
T
V
I
T
A
D
R
T
F
R
A
--
D
I
L
I
E
D
G
K
I
A
A
-------
I
G
-
D
-----
S
-----
L
E
G
D--
E
V
I
D
A
S
G
C
Y
V
M
P
G
G
I
D
P
H
T
H
L
Q
M
P
FM
G
T
--
Y
S
S
D
D
F
D
T
G
T
A
A
A
L
A
G
G
T
T
M
V
V
D
F
V
L
P
D
S
E
-
G
N
L
L
D
A
L
Q
E
W
F
Q
K
A
G
------
K
A
R
T
D
Y
S
F
H
M
A
I
-----
T
G
W
N
E
R
T
F
N
E
M
A
E
V
V
-
K
R
G
I
N
T
---
F
H
FMA
Y
---
K
---
G
A
L
M
V
N
D
D
E
M
F
A
S
F
Q
R
C
A
E
L
G
A
M
P
L
V
H
A
E
N
G
D
---------
I
V
A
Q
L
---
Q
---
A
K
L
M
A
E
G
N
D
G
P
E
A
H
A
-
Y
S
R
P
P
E
V
E
G
E
A
T
N
R
A
I
------
M
I
A
D
Q
------
A
G
V
P
L
Y
V
V
H
V
S
C
E
Q
S
H
E
A
I
R
R
A
R
Q
K
G
M
R
V
F
G
E
P
L
I
Q
H
L
T
L
D
E
S
E
Y
H
----
N
----
R
D
W
D
Y
A
A
R
R
VMS
P
P
F
R
D
K
L
N
Q
D
S
L
W
A
G
L
A
A
G
S
L
Q
C
V
A
T
D
H
C
A
F
T
T
E
Q
K
---
R
---
Y
GIG
N
F
T
K
I
P
N
G
T
G
G
L
E
E
R
-
M
P
-
V
L
W
T
R
-
G
V
R
T
G
R
L
T
P
N
E
F
V
A
V
T
-
S
T
N
I
A
K
I
L
N
I
---
Y
--
P
---
Q
KGAVV
P
-----
G
A
D
---
A
D
L
---
V
I
W
D
P
E
T
T
K
K
I
S
A
K
T
Q
H
S
S
I
D
Y
N
V
F
E
G
F
E
L
K
G
L
P
I
M
T
L
S
R
GRIAFDKGQVTAKPGD
G
R
F
I
E
R
E
P
NG
A
V
N
R
A
L
S
Q
W
K
E
I
V
A
P
R
K
V
E
R
S
A
11
PsiBlast_PDB
62.68
24%
11
- C2 -
-
4TQT
6
?
A:
[34-441]
------------------------
I
L
I
E
D
G
K
I
A
A
-------
I
G
-
D
-----
S
-----
L
E
G
D--
E
V
I
D
A
S
G
C
Y
V
M
P
G
G
I
D
P
H
T
H
L
Q
M
P
FM
G
T
--
Y
S
S
D
D
F
D
T
G
T
A
A
A
L
A
G
G
T
T
M
V
V
D
F
V
L
P
D
S
E
-------
G
N
L
L
D
A
L
Q
E
W
F
Q
K
A
G
K
A
R
T
D
Y
S
F
H
M
A
I
T
G
W
N
E
R
T
F
N
-----
E
M
A
E
V
V
-
K
R
G
I
N
T
FHF
M
A
---
Y
---
K
---
G
A
L
M
V
N
D
D
E
M
F
A
S
F
Q
R
C
A
E
L
G
A
M
P
L
V
H
A
E
N
G
D
I
V
A
Q
L
Q
A
K
L
M
A
E
G
N
---
D
---
G
P
---
E
A
H
A
Y
S
R
-------
P
P
E
V
E
G
E
A
T
N
R
A
I
------
M
I
A
D
Q
------
A
G
V
P
L
Y
V
V
H
V
S
C
E
Q
S
H
E
A
I
R
R
A
R
Q
K
G
M
R
V
F
G
E
P
L
I
Q
H
L
T
L
D
E
S
E
Y
H
----
N
RD
W
D
Y
A
A
R
R
V
M
S
----
P
P
F
R
D
K
L
N
Q
D
S
L
W
A
G
L
A
A
G
S
L
Q
C
V
A
T
D
H
C
A
F
T
T
E
Q
K
R
Y
G
I
---
G
---
N
F
T
K
I
P
N
G
T
G
G
L
E
-
E
-
R
M
P
V
L
W
T
R
-
G
V
R
T
G
R
L
T
P
N
E
F
V
A
V
T
-
S
T
N
I
A
K
I
L
N
I
---
Y
--
P
---
Q
-----
K
GAVVP
G
A
D
---
A
D
L
---
V
I
W
D
P
E
T
T
K
K
I
S
A
K
T
Q
H
S
S
I
D
Y
N
V
F
E
G
F
E
L
K
G
L
P
I
M
T
L
S
-------------------------------------------------
3
PsiBlast_PDB
61.52
28%
16
- C2 -
-
1XRT
-
PYRC_AQUAE
A:
[51-458]
------
V
K
N
G
Y
V
I
D
P
S
Q
N
L
E
G
E
F
D
I
L
V
E
N
G
K
-
I
K
-------
K
I
-
D
-----
K
N
I
L
V
P
E
A
----
E
I
I
D
A
K
G
L
I
V
C
P
G
F
I
D
I
H
V
H
L
R
D
P
--
G
Q
--
T
Y
K
E
D
I
E
S
G
S
R
C
A
V
A
G
G
F
T
T
I
V
--
C
M
P
N
T
N
-
P
P
I
-
D
N
T
T
V
V
N
Y
I
L
Q
------
K
S
K
S
V
G
L
C
R
V
L
P
T
G
T
I
T
K
G
R
K
G
K
E
I
A
D
F
Y
S
L
K
-
E
A
G
C
V
A
---
F
T
---
D
---
D
---
G
S
P
V
M
D
S
S
V
M
R
K
A
L
E
L
A
S
Q
L
G
V
P
I
M
D
H
C
E
D
D
K
---------
L
A
Y
-------------------------------
A
E
E
I
Q
I
A
R
D
G
------
I
L
A
Q
R
------
T
G
G
H
V
H
I
Q
H
V
S
T
K
L
S
L
E
I
I
E
F
F
K
E
K
G
V
K
I
T
C
E
V
N
P
N
H
L
L
----------------------------------
E
D
R
L
A
L
I
E
G
V
K
R
G
I
I
D
C
F
A
T
D
H
A
P
H
Q
T
---------------------
G
I
I
G
L
Q
-
T
-
A
L
-
P
S
A
L
E
-
L
Y
R
K
G
I
I
S
L
K
K
L
I
E
M
F
-
T
I
N
P
A
R
I
I
G
V
DLG
T
--
L
---
K
-----
L
-----
G
S
P
---
A
D
I
---
T
I
F
D
P
N
K
E
W
I
L
N
E
E
T
N
L
S
K
S
R
N
T
P
L
W
G
K
V
L
K
G
K
V
I
Y
T
I
--------------------------------------------------
56
HHSearch
61.32
27%
25
- C2 -
-
1XRT
-
PYRC_AQUAE
A:
[46-459]
-
M
L
K
L
I
V
K
N
G
Y
V
I
D
P
S
Q
N
L
E
G
E
F
D
I
L
V
E
N
G
K
I
K
K
-------
I
D
K
N
I
L
V
--
P
-----
E
A
----
E
I
I
D
A
K
G
L
I
V
C
P
G
F
I
D
I
H
V
H
L
R
D
P
--
G
Q
--
T
Y
K
E
D
I
E
S
G
S
R
C
A
V
A
G
G
F
T
T
I
V
--
C
M
P
N
T
N
-
P
P
I
D
N
T
-
T
V
V
N
Y
I
L
Q
------
K
S
K
S
V
G
L
C
R
V
L
P
T
G
T
I
T
K
G
R
K
G
K
E
I
A
D
F
Y
S
L
K
-
E
A
G
C
V
A
---
F
T
---
D
---
D
---
G
S
P
V
M
D
S
S
V
M
R
K
A
L
E
L
A
S
Q
L
G
V
P
I
M
D
H
C
E
D
D
K
---------
L
A
Y
-------------------------------
A
E
E
I
Q
I
A
R
D
G
------
I
L
A
Q
R
------
T
G
G
H
V
H
I
Q
H
V
S
T
K
L
S
L
E
I
I
E
F
F
K
E
K
G
V
K
I
T
C
E
V
N
P
N
H
L
L
----------------------------------
E
D
R
L
A
L
I
E
G
V
K
R
G
I
I
D
C
F
A
T
D
H
A
P
H
Q
T
---------------------
G
I
I
G
L
Q
-
T
-
A
L
-
P
S
A
L
E
-
L
Y
R
K
G
I
I
S
L
K
K
L
I
E
M
F
-
T
I
N
P
A
R
I
I
G
V
---
D
--
L
---
G
TLK--
L
-----
G
S
P
---
A
D
I
---
T
I
F
D
P
N
K
E
W
I
L
N
E
E
T
N
L
S
K
S
R
N
T
P
L
W
G
K
V
L
K
G
K
V
I
Y
T
I
K
-------------------------------------------------
2
PsiBlast_PDB
61.03
28%
8
- C2 -
-
1XRF
-
PYRC_AQUAE
A:
[51-458]
------
V
K
N
G
Y
V
I
D
P
S
Q
N
L
E
G
E
F
D
I
L
V
E
N
G
K
-
I
K
-------
K
I
-
D
-----
K
N
I
L
V
P
E
A
----
E
I
I
D
A
K
G
L
I
V
C
P
G
F
I
D
I
H
V
H
L
R
D
P
--
G
Q
--
T
Y
K
E
D
I
E
S
G
S
R
C
A
V
A
G
G
F
T
T
I
V
--
C
M
P
N
T
N
-
P
P
I
-
D
N
T
T
V
V
N
Y
I
L
Q
------
K
S
K
S
V
G
L
C
R
V
L
P
T
G
T
I
T
K
G
R
K
G
K
E
I
A
D
F
Y
S
L
K
-
E
A
G
C
V
A
---
F
T
---
D
---
D
---
G
S
P
V
M
D
S
S
V
M
R
K
A
L
E
L
A
S
Q
L
G
V
P
I
M
D
H
------------------------------------------------
A
E
E
I
Q
I
A
R
D
G
------
I
L
A
Q
R
------
T
G
G
H
V
H
I
Q
H
V
S
T
K
L
S
L
E
I
I
E
F
F
K
E
K
G
V
K
I
T
C
E
V
N
P
N
H
L
L
-----------------------------------
D
R
L
A
L
I
E
G
V
K
R
G
I
I
D
C
F
A
T
D
H
A
P
H
Q
T
-------------------
M
P
G
I
I
G
L
Q
-
T
-
A
L
-
P
S
A
L
E
-
L
Y
R
K
G
I
I
S
L
K
K
L
I
E
M
F
-
T
I
N
P
A
R
I
I
G
V
DLG
T
--
L
---
K
-----
L
-----
G
S
P
---
A
D
I
---
T
I
F
D
P
N
K
E
W
I
L
N
E
E
T
N
L
S
K
S
R
N
T
P
L
W
G
K
V
L
K
G
K
V
I
Y
T
I
--------------------------------------------------
46
HHSearch
59.68
22%
2
- C2 -
-
5E5C
-
HYDA_PSEAE
C:
[2-432]
---
S
L
L
I
R
G
A
T
V
V
T
H
E
E
--
S
Y
R
A
D
V
L
C
A
N
G
L
I
Q
A
-------
I
G
E
N
LETP-
S
-----
G
C
----
D
V
L
D
G
G
G
Q
Y
L
M
P
G
G
I
D
P
H
T
H
M
Q
L
P
--
F
M
GT
V
A
S
E
D
F
F
S
G
T
A
A
G
L
A
G
G
T
T
S
I
I
--
D
F
V
I
P
N
-
P
R
Q
S
L
L
-
E
A
F
H
T
W
R
G
------
W
A
-
Q
K
S
A
A
D
Y
G
F
H
V
A
I
T
W
W
S
-
D
E
V
A
R
E
M
G
E
L
V
A
Q
H
G
V
N
S
---
F
-H--
F
---
M
AYK
N
A
I
M
A
A
D
D
T
L
V
A
S
F
E
R
C
L
E
L
G
A
V
P
T
V
H
A
E
N
G
E
---------
L
V
F
H
L
---
Q
QKL
L
A
---
Q
G
L
T
G
P
E
A
H
P
-
L
S
R
P
P
Q
V
E
G
E
A
A
S
R
A
I
------
R
I
A
E
T
------
L
G
T
P
L
Y
L
V
H
I
S
S
R
E
A
L
D
E
I
A
Y
A
R
A
K
G
Q
P
V
Y
G
E
V
L
A
G
H
L
L
L
D
D
S
V
Y
R
HPDW
A
----
T
A
A
G
Y
V
M
S
----
P
P
F
R
P
V
E
H
Q
E
A
L
W
R
G
L
Q
S
G
N
L
H
T
T
A
T
D
H
C
C
F
C
A
E
Q
K
---
A
MGR
D
---
D
F
S
K
I
P
N
G
T
A
G
I
E
-
D
-
R
M
-
A
L
L
W
D
A
G
V
N
S
G
R
L
S
M
H
E
F
V
A
L
T
-
S
T
N
T
A
K
I
F
N
L
F--
P
R-
K
---
G
AIR--
V
-----
G
A
D
---
A
D
L
---
V
L
W
D
P
Q
G
S
R
T
L
S
A
A
T
H
H
Q
R
V
D
F
N
I
F
E
G
R
T
V
R
G
I
P
S
H
T
I
S
-------------------------------------------------
43
HHSearch
59.20
22%
12
- C2 -
-
3HM7
-
ALLB_BACHD
B:
[4-431]
K
R
F
D
L
I
I
R
S
S
T
V
V
T
E
T
T
--
T
Y
R
A
D
V
A
I
R
N
G
I
V
S
A
-------
I
T
E
P
GSISS
D
-----
D
G
----
P
A
I
D
G
T
G
L
H
L
F
P
G
M
V
D
V
H
V
H
F
N
E
P
--
G
R
--
T
E
W
E
G
F
A
S
G
S
K
S
L
A
A
G
G
V
T
T
Y
F
--
D
M
P
L
N
S
N
P
P
T
I
T
R
-
E
E
L
D
K
K
R
Q
------
L
A
N
E
K
S
L
V
D
Y
R
F
W
G
G
L
V
P
G
N
----
I
D
H
L
Q
D
L
H
-
D
G
G
V
I
G
---
F
K
A
--
F
MSE
C
GTD
D
F
Q
F
S
H
D
E
T
L
L
K
G
M
K
K
I
A
A
L
G
S
I
L
A
V
H
A
E
S
N
E
---------
M
V
N
A
L
T
T
I
A
---
I
E
---
E
Q
R
L
T
V
K
D
Y
S
-
E
A
R
P
I
V
S
E
L
E
A
V
E
R
I
L
------
R
F
A
Q
L
------
T
C
C
P
I
H
I
C
H
V
S
S
R
K
V
L
K
R
I
K
Q
A
K
G
E
G
V
N
V
S
V
E
T
C
P
H
Y
L
L
F
S
L
D
E
F
A
----
E
----
I
G
Y
L
A
K
C
A
----
P
P
L
R
E
R
Q
E
V
E
D
L
W
D
G
L
M
A
G
E
I
D
L
I
S
S
D
H
S
P
S
L
P
Q
M
K
---
T
G--
K
---
T
I
F
E
V
W
G
G
I
A
G
C
Q
-
N
-
T
L
-
A
V
M
L
T
E
G
Y
H
K
R
K
M
P
L
T
Q
I
V
Q
L
L
-
S
T
E
P
A
K
R
F
G
L
---
Y
PQ
K
---
G
TIQ--
V
-----
G
A
E
---
A
S
F
---
T
L
I
D
L
N
E
S
Y
T
L
N
A
S
D
L
Y
Y
R
H
P
I
S
P
Y
V
G
Q
R
F
R
G
K
V
K
H
T
I
C
-------------------------------------------------