@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLH5: (2017-11-02 )
MKISLLGSGRVAFHLAKALLAQGHHIAQVYARDFEKTKKFAEQIQAKACQSLQEFQPTDLIILAVSDSAITELATQVHELFPKMLMVHTSGSTDIQVISQVHEKAGVFYPLQTFSLERDVDWKATPLFVEATNKDDLVILSDLANSLSKRVYQYTSKQRLTLHLAAVFACNFSNYCFDMAKQVVDAEQVDFGLLYPLILETAKKATENDPKQMQTGPAMRGDQNILVMHQSLLAQANRDDLKQVYQLLSDGIVKRHHSS
Atome Classification :
(20 SA)
........-.10........20....-....30.....--...40...----------------------------.--------------------------.--..--.50.-.....---.-..60.......--.--70.........-80-........90.......--.100-.---.......110-.......120-------.-........130-.--.-......140.....---..150------------------.....-....160....--...170..----.....180....-------------...190.......200.......210.......220.......230.......240......--...250.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
I
S
L
LGS-
G
R
V
A
F
H
L
A
K
A
L
L
AQG
H
H
-
I
A
Q
V
Y
A
R
D
F
E
K
--
T
K
K
F
A
E
Q
I
----------------------------
Q
--------------------------
A
--
K
A
--
C
Q
-
S
-
L
Q
EFQ---P-T
D
L
I
I
L
AVS
D
S
--
A
--
I
-
T
E
L
A
T
Q
V
H
E
-
L
F
-
P
K
M
L
M
V
HTSGS
T
D
I
Q
V
I
--
S
Q
V
--
H
---
E
KA
G
V
F
Y
PLQ-TFSLERDV---------D-WKAT
P
L
F
V
E
A--T--N-KD
D
L
V
I
L
S
D
L
A
N
S
L
---
S
K
R
--------------------
V
Y
Q
Y
T-SK
Q
R
L
T
L
H
L
A
A
--
V
F
ACNF
S
N
----
Y
C
F
D
M
A
K
Q
V
V
D
A
-------------
E
QV
D
F
G
L
L
Y
P
L
I
L
E
T
A
K
KATEN
D
P
K
QMQTGPAMRGDQ
N
I
L
V
M
H
Q
S
L
L
AQA
N
R
D
D
--
L
K
Q
V
Y
Q
--
L
L
S
D
G
I
V
K
RHHSS
15
HHSearch
75.03
40%
-28
- C3 -
-
3D1L
-
?
B:
[11-265]
T
P
I
V
L
I
G
A
-
G
N
L
A
T
N
L
A
K
A
L
Y
R
K
G
F
R
I
V
Q
-
V
Y
S
R
T
E
E
S
--
A
R
E
L
A
Q
K
V
----------------------------
E
--------------------------
A
--
E
Y
--
T
T
-
D
L
A
E
V
N
P
---
Y
-
A
K
L
Y
I
V
S
L
K
D
S
--
A
--
F
-
A
E
L
L
Q
G
I
V
E
-
G
K
R
E
E
A
L
M
V
H
T
A
G
S
I
P
M
N
V
W
--
E
G
H
--
V
---
P
H
Y
G
V
F
Y
P
M
Q
-
T
F
S
K
Q
R
E
V
---------
D
-
F
K
E
I
P
F
F
I
E
A
--
S
--
S
-
T
E
D
A
A
F
L
K
A
I
A
S
T
L
---
S
N
R
--------------------
V
Y
D
A
D
-
S
E
Q
R
K
S
L
H
L
A
A
--
V
F
T
C
N
F
T
N
----
H
M
Y
A
L
A
A
E
L
L
K
K
-------------
Y
N
L
P
F
D
V
M
L
P
L
I
D
E
T
A
R
K
V
H
E
L
E
P
K
T
A
Q
T
G
P
A
I
R
Y
D
E
N
V
I
G
N
H
L
R
M
L
A
D
D
-
P
A
---
M
Q
R
L
Y
E
--
L
L
S
R
S
I
H
E
R
----
1
PsiBlast_PDB
74.41
41%
-46
- C3 -
-
3D1L
-
?
A:
[13-265]
--
I
V
L
I
G
A
-
G
N
L
A
T
N
L
A
K
A
L
Y
R
K
G
F
R
-
I
V
Q
V
Y
S
R
T
E
E
S
--
A
R
E
L
A
Q
K
V
----------------------------
E
--------------------------
A
--
E
Y
--
T
T
-
D
-
L
A
E
V
N
---
P
Y
A
K
L
Y
I
V
S
L
K
D
S
--
A
--
F
-
A
E
L
L
Q
G
I
V
E
G
K
R
-
E
E
A
L
M
V
H
T
A
G
S
I
P
M
N
V
W
--
E
G
H
--
V
---
P
H
Y
G
V
F
Y
P
M
Q
-
T
F
---
R
E
V
---------
D
-
F
K
E
I
P
F
F
I
E
A
--
S
--
S
-
T
E
D
A
A
F
L
K
A
I
A
S
T
L
---
S
N
R
--------------------
V
Y
D
A
D
-
S
E
Q
R
K
S
L
H
L
A
A
--
V
F
T
C
N
F
T
N
----
H
M
Y
A
L
A
A
E
L
L
K
K
-------------
Y
N
L
P
F
D
V
M
L
P
L
I
D
E
T
A
R
K
V
H
E
L
E
P
K
T
A
Q
T
G
P
A
I
R
Y
D
E
N
V
I
G
N
H
L
R
M
L
A
----
D
D
P
A
M
Q
R
L
Y
E
--
L
L
S
R
S
I
H
E
R
----
35
HHSearch
47.75
13%
-55
- C3 -
-
4E21
1
?
B:
[23-274]
M
Q
I
G
M
I
G
L
-
G
R
M
G
A
D
M
V
R
R
L
R
K
G
G
H
E
-
C
V
-
V
Y
D
L
N
V
N
A
--
V
Q
A
L
E
R
E
-----------------------------
G
--------------------------
I
--
A
G
--
A
R
-
S
I
E
E
F
C
A
K
LV
K
-
P
R
V
V
W
L
M
V
P
A
A
--
V
--
V
-
D
S
M
L
Q
R
M
T
P
-
L
L
A
A
N
D
I
V
I
D
G
G
N
S
H
Y
Q
D
D
I
R
R
A
D
Q
--
M
---
R
A
Q
G
I
T
Y
V
D
V
-
G
T
S
G
G
I
F
G
---------
L
-
E
R
G
Y
C
L
M
I
G
G
--
E
----
K
Q
A
V
E
R
L
D
P
V
F
R
T
L
---
A
P
G
IGAAPRTPGREKREGTAELG
Y
L
H
C
G
P
S
G
A
G
H
----
F
V
--
K
M
V
H
N
G
I
E
Y
G
L
M
A
A
Y
A
E
G
L
N
I
L
H
H
A
NAGPLRNPDFYR
Y
D
L
D
L
A
D
I
T
E
V
W
R
R
G
--------------------------------------------------------------
21
HHSearch
44.84
12%
-59
- C3 -
-
4PZC
-
?
C:
[4-247]
R
T
V
G
I
V
G
A
-
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
-
V
V
-
M
V
D
I
S
D
A
A
--
V
Q
K
G
V
A
T
V
ASSLDRLIKK------------------
E
KLTEADKASAL---------------
A
--
R
I
K-
G
S
-
T
S
Y
D
D
L
K
---
A
-
T
D
I
V
I
E
A
A
T
E
N
YD
L
--
K
-
V
K
I
L
K
Q
I
D
G
-
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
--
A
A
V
--
T
SRA
D
R
F
I
G
M
H
F
F
N
-
P
V
P
V
M
----------------
A
L
V
E
L
I
R
G
LQ
T
--
S
-
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
---
G
K
Y
--------------------
P
I
T
V
K
-
N
S
P
G
F
---------
V
V
N
R
I
L
C
----
P
M
I
N
E
A
F
C
V
L
G
E
-------------
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
---------
H
P
I
G
P
L
A
L
A
D
M
I
G
L
D
T
M
L
A
V
M
E
V
L
---------------------------
3
PsiBlast_PDB
43.99
34%
-177
- C3 -
-
3WS7
1
?
A:
[21-94]
M
R
V
G
F
I
G
L
-
G
I
M
G
G
P
M
A
T
H
L
L
K
A
G
F
--
L
A
A
V
Y
N
R
T
R
E
K
--
T
K
P
F
A
E
A
G
----------------------------
V
--------------------------
Y
--
V
A
--
E
S
-
P
-
A
D
L
A
K
---
R
-
V
D
V
V
I
V
M
V
S
D
A
--
P
--
D
-
V
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
43.34
16%
-63
- C3 -
-
3MOG
1
PAAH_ECOLI
C:
[6-249]
Q
T
V
A
V
I
G
S
-
G
T
M
G
A
G
I
A
E
V
A
A
S
H
G
H
Q
-
V
L
-
L
Y
D
I
S
A
E
A
--
L
T
R
A
I
D
G
I
----------------------------
H
ARLNSRVTRGKLTAETCERTL-----
K
--
R
L
I-
P
V
-
T
D
I
H
A
L
A
---
A
-
A
D
L
V
I
E
A
A
S
E
R
L-
E
--
V
K
K
A
L
F
A
Q
L
A
E
-
V
C
P
P
Q
T
L
L
T
T
N
T
S
S
I
S
I
T
A
I
--
A
A
E
--
I
KNP
E
R
V
A
G
L
H
F
F
N
-
P
A
P
V
M
----------------
K
L
V
E
V
V
S
G
--
L
AT
A
-
A
E
V
V
E
Q
L
C
E
L
T
L
S
W
---
G
K
Q
--------------------
P
V
R
C
H
-
S
T
P
G
F
---------
I
V
N
R
V
A
R
----
P
Y
Y
S
E
A
W
R
A
L
E
E
-------------
Q
V
A
A
P
E
V
I
D
A
A
L
R
D
G
A
G
---------
F
P
M
G
P
L
E
L
T
D
L
I
G
Q
D
V
N
F
A
V
T
C
S
V
---------------------------
25
HHSearch
42.73
13%
-75
- C3 -
-
4R1N
-
?
A:
[2-245]
K
K
V
F
V
L
G
A
-
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
-
V
I
-
V
R
D
I
K
E
E
F
--
V
D
R
G
I
A
T
I
T
K
S
L
S
K
L
V
A
K
------------------
E
KIT
E
A
D
K
E
E
I
L
---------------
S
--
R
I
S
-
G
T
-
T
D
M
K
L
A
A
---
D
-
C
D
L
V
V
E
A
A
I
E
N
M
K
I
--
K
-
K
E
I
F
A
E
L
D
G
-
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
--
A
S
A
--
T
KRA
D
K
V
I
G
M
H
F
F
N
-
P
A
P
V
M
K
-------------
L
V
E
V
I
-
R
G
A
A
--
T
--
S
-
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
---
G
K
T
--------------------
P
V
E
V
A
-
E
A
P
G
F
---------
V
V
N
R
I
L
I
----
P
M
I
N
E
A
T
F
I
L
Q
E
-------------
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
---------
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
I
M
D
V
L
---------------------------
2
PsiBlast_PDB
42.55
34%
-176
- C3 -
-
3W6Z
1
?
A:
[21-91]
M
R
V
G
F
I
G
L
-
G
I
M
G
G
P
M
A
T
H
L
L
K
A
G
F
--
L
A
A
V
Y
N
R
T
R
E
K
--
T
K
P
F
A
E
A
G
----------------------------
V
--------------------------
Y
--
V
A
--
E
S
-
P
-
A
D
L
A
K
---
R
-
V
D
V
V
I
V
M
V
S
D
A
--
P
--
D
-
V
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
42.40
12%
-95
- C3 -
-
3DFU
-
?
B:
[7-219]
L
R
V
G
I
F
D
D
-
G
S
S
T
V
N
M
A
E
K
L
D
S
V
G
H
Y
-
V
T
-
V
L
H
A
---------------------------------------------------------------------------------
P
E
D
I
R
---
D
-
F
E
L
V
V
I
D
A
--
H
--
G
--
V
-
E
G
Y
V
E
K
L
S
A
-
F
A
R
R
G
Q
M
F
L
H
T
S
L
T
H
G
I
T
V
M
--
D
P
L
--
E
T
S
G
G
I
V
M
S
A
H
----
P
I
G
------------------
Q
D
R
W
V
A
S
A
--
L
--
D
-
E
L
G
E
T
I
V
G
L
L
V
G
E
L
---
G
G
S
--------------------
I
V
E
I
A
-
D
D
K
R
A
Q
L
A
A
A
L
--
T
Y
A
-
G
F
L
S
----
T
L
Q
R
D
A
S
Y
F
L
D
E
-------------
F
L
G
D
P
D
V
-------
T
S
-----
D
I
V
M
D
S
A
Q
Q
F
Q
A
L
P
S
L
D
E
V
I
A
Q
Y
D
S
I
N
N
--
P
G
---
R
Q
R
L
F
R
--
D
L
A
R
R
Q
A
E
I
S
R
A
-
23
HHSearch
40.68
13%
-35
- C3 -
-
2HDH
1
HCDH_HUMAN
A:
[5-254]
K
H
V
T
V
I
G
G
-
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
-
V
V
-
L
V
D
Q
T
E
D
I
--
L
A
K
S
K
K
G
I
----------------------------
E
E
S
L
R
K
V
A
K
K
K
F
A
EN
P
K
A
G
D
E
F
V
A
K
T
L
S
--
T
I
A
T
S
T
-
D
A
A
S
V
V
H
---
S
-
T
D
L
V
V
E
A
I
V
E
N
--
L
K
V
K
-
N
E
L
F
K
R
L
D
K
-
R
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
--
A
N
A
--
T
TRQ
D
R
F
A
G
L
H
F
F
N
-
P
V
P
V
M
----------------
K
L
V
E
V
I
K
T
PM
T
--
S
-
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
---
G
K
H
--------------------
P
V
S
C
K
-
D
T
P
G
F
---------
I
V
N
R
L
L
V
----
P
Y
L
M
E
A
I
R
L
Y
E
R
-------------
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
---------
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---------------------------
22
HHSearch
40.67
12%
-59
- C3 -
-
4PZE
2
?
G:
[4-247]
R
T
V
G
I
V
G
A
-
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
-
V
V
-
M
V
D
I
S
D
A
A
--
V
Q
K
G
V
A
T
V
ASSLDRLIKK------------------
E
KLTEADKASAL---------------
A
--
R
I
K-
G
S
-
T
S
Y
D
D
L
K
---
A
-
T
D
I
V
I
E
A
A
T
E
N
YD
L
--
K
-
V
K
I
L
K
Q
I
D
G
-
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
--
A
A
V
--
T
SRA
D
R
F
I
G
M
H
F
F
N
-
P
V
P
V
M
----------------
A
L
V
E
L
I
R
G
LQ
T
--
S
-
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
---
G
K
Y
--------------------
P
I
T
V
K
-
N
S
P
G
F
---------
V
V
N
R
I
L
C
----
P
M
I
N
E
A
F
C
V
L
G
E
-------------
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
---------
H
P
I
G
P
L
A
L
A
D
M
I
G
L
D
T
M
L
A
V
M
E
V
L
---------------------------
26
HHSearch
39.93
11%
-25
- C3 -
-
3C24
1
?
A:
[12-282]
K
T
V
A
I
L
G
A
G
G
K
M
G
A
R
I
T
R
K
I
H
D
S
A
H
H
-
L
A
-
A
I
E
I
A
P
E
G
--
R
D
R
L
Q
G
M
-----------------------------
G
--------------------------
I
--
P
---
L
T
-
D
G
D
G
W
I
D
---
E
-
A
D
V
V
V
L
A
L
P
D
N
--
I
--
I
-
E
K
V
A
E
D
I
V
P
-
R
V
R
P
G
T
I
V
L
I
L
D
A
A
A
P
Y
A
G
V
--
M
P
E
RA
D
---
I
T
Y
F
I
G
H
P
C
H
P
P
L
F
N
D
E
T
D
P
A
A
R
T
DYHG
G
I
A
K
Q
A
I
V
C
A
L
M
--
Q
--
G
P
E
E
H
Y
A
I
G
A
D
I
C
E
T
M
W
SP
V
T
R
--------------------
T
H
R
V
T
-
T
E
Q
L
A
I
L
E
P
G
L
SE
M
V
A
M
P
F
V
E
----
T
M
V
H
A
V
D
E
C
A
D
R
-------------
Y
G
I
D
R
Q
A
A
L
D
F
M
I
G
H
L
N
V
E
I
A
M
W
F
G
Y
S
-
P
K
V
---
A
A
L
R
L
M
E
F
A
K
D
I
V
V
K
E
---
D
--
W
R
E
A
L
N
P
A
K
V
K
Q
A
A
E
L
-----
24
HHSearch
39.43
13%
-36
- C3 -
-
1F0Y
3
HCDH_HUMAN
A:
[16-265]
K
H
V
T
V
I
G
G
-
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
-
V
V
-
L
V
D
Q
T
E
D
I
--
L
A
K
S
K
K
G
I
E
E
S
L
R
K
V
A
K
K
K
FAEN
P
K
A
G
D
E
F
V
E
K
T
L
S
T
--------------------------
I
--
A
T
--
S
T
-
D
A
A
S
V
V
H
---
S
-
T
D
L
V
V
E
A
I
V
E
N
--
L
K
V
K
-
N
E
L
F
K
R
L
D
K
-
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
I
--
A
N
A
--
T
TRQ
D
R
F
A
G
L
H
F
F
N
-
P
V
P
V
M
----------------
K
L
V
E
V
I
K
T
PM
T
--
S
-
Q
K
T
F
E
S
L
V
D
F
S
K
A
L
---
G
K
H
--------------------
P
V
S
C
K
-
D
T
P
G
F
---------
I
V
N
R
L
L
V
----
P
Y
L
M
E
A
I
R
L
Y
E
R
-------------
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
---------
Y
P
M
G
P
F
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
V
D
G
W
---------------------------
31
HHSearch
38.91
11%
-49
* C3 *
-
3F3S
2
CRYL1_HUMAN
A:
[4-225]
G
C
V
V
I
V
G
S
-
G
V
I
G
R
S
W
A
M
L
F
A
S
G
G
F
Q
-
V
K
-
L
Y
D
I
E
Q
Q
Q
--
I
R
N
A
L
E
N
I
R
K
E
M
K
L
L
E
Q
A
------------------
G
SLKGSLS
V
E
E
Q
L
--------------
S
L
I
S
G
--
C
P
-
N
I
Q
E
A
V
E
---
G
-
A
M
H
I
Q
E
C
V
P
E
D
--
L
E
L
K
-
K
K
I
F
A
Q
L
D
S
-
I
I
D
D
R
V
I
L
S
S
S
T
S
C
L
M
P
S
K
L
--
F
A
G
--
L
VHV
K
Q
C
I
V
A
H
P
V
N
-
P
P
Y
Y
----------------
I
P
L
V
E
L
V
P
H
--
P
ET
A
-
P
T
T
V
D
R
T
H
A
L
M
K
K
I
---
G
Q
C
--------------------
P
M
R
V
Q
-
K
E
V
A
G
F
--------
V
L
N
R
L
Q
Y
----
A
I
I
S
E
A
W
R
L
V
E
E
-------------
G
I
V
S
P
S
D
L
D
L
V
M
S
E
G
L
-------------------------------------------------------------
33
HHSearch
38.86
15%
-51
- C3 -
-
1ZEJ
1
?
A:
[13-236]
M
K
V
F
V
I
G
A
-
G
L
M
G
R
G
I
A
I
A
I
A
-
S
K
H
E
-
V
V
-
L
Q
D
V
S
E
K
A
--
L
E
A
A
R
E
Q
I
PEELLS----------------------
K
--------------------------
I
--
E
F
--
T
T
-
T
-
L
E
K
V
K
---
D
-
C
D
I
V
M
E
A
V
F
E
D
L
-
N
--
T
K
V
E
V
L
R
E
V
E
R
-
L
--
T
N
A
P
L
C
S
N
T
S
V
I
S
V
D
D
I
--
A
E
R
--
L
DSP
S
R
F
L
G
V
H
W
M
N
-
P
P
H
V
----------------
M
P
L
V
E
I
V
I
S
RF
T
--
D
-
S
K
T
V
A
F
V
E
G
F
L
R
E
L
---
G
K
E
--------------------
V
V
V
C
K
-
G
Q
--
S
---------
L
V
N
R
F
N
A
----
A
V
L
S
E
A
S
R
M
I
-
E
-------------
E
G
V
R
A
E
D
V
D
R
V
W
K
H
H
L
G
L
------
L
Y
T
L
F
G
P
L
G
N
L
D
Y
I
G
L
D
V
A
Y
Y
A
S
L
Y
L
---------------------------
29
HHSearch
38.75
11%
-82
- C- -
-
1ZCJ
-
ECHP_RAT
A:
[297-536]
S
S
V
G
V
L
G
L
-
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
-
V
V
-
A
V
E
S
D
P
K
Q
--
L
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
------------------
A
H
Q
N
G
Q
A
S
A
K-----------------
P
--
K
L
R
-
F
S
S
S
-
T
K
E
L
S
---
T
-
V
D
L
V
V
E
A
V
F
E
D
--
M
N
L
K
-
K
K
V
F
A
E
L
S
A
-
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
--
A
S
S
--
T
DRP
Q
L
V
I
G
T
H
F
F
S
-
P
A
H
V
M
----------------
R
L
L
E
V
I
P
S
RY
S
--
S
-
P
T
T
I
A
T
V
M
S
L
S
K
K
I
---
G
K
I
--------------------
G
V
V
V
G
-
N
C
Y
G
F
---------
V
G
N
R
M
L
A
----
P
Y
Y
N
Q
G
F
F
L
L
E
E
--------------
G
S
K
P
E
D
V
D
G
V
L
E
-
E
F
G
---------
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
---------------------------
7
PsiBlast_PDB
38.67
39%
-111
- C3 -
-
1LSS
1
TRKA_METJA
A:
[5-49]
M
Y
I
I
I
A
G
I
-
G
R
V
G
Y
T
L
A
K
S
L
S
E
K
G
H
D
-
I
V
L
I
---
D
I
D
K
D
I
C
K
K
A
S
A
E
I
----------------------------
D
--------------------------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
37.63
11%
-21
- C3 -
-
3C24
2
?
B:
[12-282]
K
T
V
A
I
L
G
A
G
G
K
M
G
A
R
I
T
R
K
I
H
D
S
A
H
H
-
L
A
-
A
I
E
I
A
P
E
G
--
R
D
R
L
Q
G
M
-----------------------------
G
--------------------------
I
--
P
---
L
T
-
D
G
D
G
W
I
D
---
E
-
A
D
V
V
V
L
A
L
P
D
N
--
I
--
I
-
E
K
V
A
E
D
I
V
P
-
R
V
R
P
G
T
I
V
L
I
L
D
A
A
A
P
Y
A
G
V
--
M
P
E
RA
D
---
I
T
Y
F
I
G
H
P
C
H
P
P
L
F
N
D
E
T
D
P
A
A
R
T
DYHG
G
I
A
K
Q
A
I
V
C
A
L
M
--
Q
--
G
P
E
E
H
Y
A
I
G
A
D
I
C
E
T
M
W
SP
V
T
R
--------------------
T
H
R
V
T
-
T
E
Q
L
A
I
L
E
P
G
L
SE
M
V
A
M
P
F
V
E
----
T
M
V
H
A
V
D
E
C
A
D
R
-------------
Y
G
I
D
R
Q
A
A
L
D
F
M
I
G
H
L
N
V
E
I
A
M
W
F
G
Y
S
-
P
K
V
---
A
A
L
R
L
M
E
F
A
K
D
I
V
V
K
E
---
D
--
W
R
E
A
L
N
P
A
K
V
K
Q
A
A
E
L
-----
17
HHSearch
36.99
12%
-28
- C3 -
-
4J0E
-
HCDH1_CAEEL
A:
[12-260]
R
N
V
A
I
V
G
S
-
G
Q
M
G
S
G
I
A
Q
V
T
A
S
S
G
F
N
-
V
M
-
L
A
D
V
N
K
K
A
--
L
D
R
A
M
K
A
I
S
Q
S
V
T
H
L
S
K
K
------------------
Q
K
G
T
D
K
E
K
S
D
F
V
T
L
T
M
-----------
S
--
R
I
K
T
C
N
-
N
V
S
T
A
V
A
---
D
-
A
D
L
I
I
E
A
A
I
E
N
I
-
D
--
L
K
R
G
I
F
A
Q
I
E
Q
-
S
C
K
K
D
S
I
L
T
T
N
T
S
S
F
L
L
E
D
V
--
A
K
G
--
L
QDK
T
R
F
G
G
L
H
F
F
N
-
P
V
P
V
M
----------------
K
L
L
E
V
I
R
S
DD
T
--
S
-
D
E
T
Y
A
T
L
I
K
F
G
T
A
V
---
G
K
T
--------------------
T
V
A
C
K
-
D
S
P
G
F
---------
I
V
N
R
L
L
I
----
P
Y
F
F
E
A
A
R
M
Y
E
R
-------------
G
D
A
S
M
T
D
I
D
E
A
M
K
L
G
A
G
---------
H
P
M
G
P
F
E
L
A
D
Y
I
G
L
D
T
V
K
F
V
M
D
G
W
---------------------------
34
HHSearch
36.08
14%
-
- C3 -
-
2WTB
-
MFP2_ARATH
A:
[313-575]
K
K
V
A
I
I
G
G
-
G
L
M
G
S
G
I
A
T
A
L
I
L
S
N
Y
P
-
V
I
-
L
K
E
V
N
E
K
F
--
L
E
A
G
I
G
R
V
----------------------------
K
A
N
L
Q
S
R
V
RS
Q
E
K
F
E
K
T
M
---------
S
--
L
L
K
-
G
S
-
L
D
Y
E
S
F
R
---
D
-
V
D
M
V
I
E
A
V
I
E
N
I
-
S
--
L
K
Q
Q
I
F
A
D
L
E
K
-
Y
C
P
Q
H
C
I
L
A
S
N
T
S
T
I
D
L
N
K
I
--
G
E
R
--
T
KSQ
D
R
I
V
G
A
H
F
F
S
-
P
A
H
I
M
P
----------------
L
L
E
I
V
R
T
NH
T
--
S
-
A
Q
V
I
V
D
L
L
D
V
G
K
K
I
---
K
K
T
--------------------
P
V
V
V
G
-
N
C
T
G
F
---------
A
V
N
R
M
F
F
----
P
Y
T
Q
A
A
M
F
L
V
E
C
--------------
G
A
D
P
Y
L
I
D
R
A
I
S
-
K
F
G
---------
M
P
M
G
P
F
R
L
C
D
L
V
G
F
G
V
A
I
A
T
A
T
Q
F
---------------------------