@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLI7: (2017-11-02 )
MLNGLNIDQWVMARDRYRLNRLRKDKKANTAEIEKLFEQSNAKVRQRFERLPKITLNQDLPVTQYADRLIEAIQKHQVIIVAGETGSGKTTQLPQIAMLAGRGLTGMIGHTQPRRLAARSVSQRIAEEVGEKLGESIGFKIRFNEQGSQDSIVRLMTDGILLAELGNDRFVSKYDTIIIDEAHERSLNIDFIMGYLKQLLPKRPDLKVIVTSATLDVNRFSNYFNNAPIFEVEGRSYPVEVRYRPISEMNIGGSDDDEFDDFEENLPRAVVQAVEECFADAEEKGHPEHADILIFSSTEQEIRELQETLQKYGPRHTEILPLYARLAVSEQQKIFSPSGKGRRIIIATNVAETALTVPNIRYVIDSGFARISRYNYRSRVQRLPIEAISQAAANQRKGRCGRVAPGVCIRLYSEEDFLSRPEFTEPEIKRTNLASVILQMQTLGLGELENFDFIEPPDFRLVNDGRKLLIELGALNEKKNELTKVGQMMARMPIDPRLARMIVGGAHFGVLKEILVVVSALAVQDPRERPADKQMQADQKHALFKEADSDFLFYLKLWDTLNPKGEAGMSENKRRQFAKQHFLSWLRLREWKQIHQQLVELAEGLKLSFNEKPANYENLHRALLTGLLSFIANKTDERNTFMAVRQQKAKVFPASTLHKTNTAWVMAFEMVETSQVYLRTLAKIDPEWILLAARDLLKYHYFEPHWSKKAGIVNAYAQISLFGLIIEPKRLVNFEKVDQPAAHEIFLRDALTTGNLGTVPPFLKHNLLKLEEVERVEDKLRRRDLVVDEETIYQFYESKIPEEIASRRSFEDWRATVEAKNPRYLYVEDDALWLNDRPTTQQFPDHLHNGQLRLATTYRFDPSHDEDGATVQIPVQALPQVDENIWSWGIPGWRLDLIEALLKALPKDKRRNLVPIPDTARKLMQGIDAVHLRQHIFSYLAFALRGEQITDKDFSFERIDPYLVPFIKVIDEKGKLIAKGRDLAELKARCRVETHRPVKQQKGEFKTFPENFTFEASQKVTGVVVKQYQALVPTKNFAELEAKDESGVVIQTFNDQAEAIKQHREGIIRLVHMQLGDLVRQLKKQISKPLALAYSPLGDKAKLEQMLVYATLQMAITTLPINADEFNKLLDQVKKQFLSYGQQALEQLGDIYIQWQQIRRQLLVLDPDVFGRSIDDIEDQLDLMSLGNFVYCQPVDLWQEYPRYLKALLLRLDRLPNNLQRDHAAIDDVDPWMDKVFKFKNDPRIKELYLMLEELRISLFSQPMKTKMPISPTRLQKLWDRLGIS
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------.......-----------..10........20-------------------------------.........-------------------30........40---........50---.........60........70........80........90.......----.--100---...--.---...110.......120.......130.......140.......150........160......-.170.......180.......190.......200.......210.......220.......230.......240........------250.......260......----------------------..270.----------......280...-.-...290.......300.--------......----310---..--------.------.--...--------.320.......330....-------.-------..340----.-------.-.......350.......360.......370.......380.......390.......400.......410......-.-420-........430.......440.......450--.......460.......470.......480.......490.......500.......510.......520.......530....-...540.......550.......560.......570.......580.......590.......600.....-----..----610--.----....----....620.......630-.....-..640.-..-....650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------MLNGL
N
I
-----------
D
Q
W
V
M
A
R
D
R
Y
R
L
N
--------------------------------
R
L
RKDKKA
N
-------------------
T
A
E
I
E
K
L
F
E
QS
N
---
A
K
V
R
Q
R
F
E
R----LP
K
I
TLNQDL
P
V
T
Q
Y
A
D
R
L
I
E
A
I
Q
KH
Q
V
I
I
V
AGETGSGKTTQL
P
Q
I
A
M
----L--AGR---GLT--G---MIGHT
Q
P
R
R
L
A
A
R
S
V
S
Q
R
I
A
E
E
V
G
E
K
L
G
E
SI
G
F
K
I
R
FNEQGS
Q
D
S
-
I
V
R
L
M
TD
G
I
L
L
A
ELGND-R
F
V
SKY
D
T
I
I
I
DEAHERSL
N
I
D
F
I
M
G
Y
L
K
Q
LLPKRPD
L
K
V
I
V
T
S
A
T
L
D
V
N
R
F
S
N
YFNNA
P
I
F
E
VEGRS
Y
P
V
E
V
-
R
Y
R
PISEM------NIGGSDDD
E
F
D
-
D
F
E
E
N
L
P
----------------------
R
A
V
V
Q
A
----------
V
E
E
C
F
A
D
A
E
EKG-H-PEHA
D
I
L
I
FSS
T
E
Q
E
I
R
--------
E
L
Q
E
T
L
----
Q
K----YG--------P------R--HTE--------
I
L
P
L
Y
A
R
L
AVS
E
Q
Q
K
IFS-------P-------SGK------G-------
R
-
R
I
I
I
ATNVAETALTVP
N
I
R
Y
V
IDS
G
F
A
R
I
S
R
Y
N
Y
R
S
R
V
Q
RL
P
I
E
A
I
S
Q
A
A
ANQRKGRCGRVAP
G
V
C
I
R
L
YSE
E
D
FL-S-R-P-EFTEP
E
I
K
R
T
N
L
A
S
V
I
L
Q
M
Q
TLGLGELENFD--FIEPPD
F
R
L
VNDG
R
K
L
L
I
E
LGALN
E
K
K
N
E
L
T
K
V
G
Q
M
M
A
RMPI
D
P
R
L
A
R
M
I
VGG
A
H
F
G
V
L
K
E
I
L
V
V
V
S
A
L
AVQDPRERPA
D
K
Q
M
Q
-
A
D
Q
K
H
A
L
F
K
EADS
D
F
L
F
Y
L
K
L
W
DTLNPKGEAGM
S
E
N
K
R
R
Q
F
A
K
Q
H
F
L
S
W
L
R
L
R
E
W
K
Q
I
H
Q
Q
L
V
E
L
A
EG
L
K
L
-----SF----N----E----KPA
N
----
Y
E
N
L
H
R
A
L
L
T
G
L
L
S
F
I
A-NKTDE-R
N
T
F
M
A
-
V
R
-
Q
QKAKVFPASTLHKTN
T
A
W
V
M
A
F
E
MV
E
T
S
Q
V
Y
L
R
T
L
A
KI
D
P
E
W
I
L
L
A
A
R
D
L
L
K
Y
HYFEPHWSKKA
G
I
V
N
A
Y
A
Q
I
S
L
F
G
L
I
I
E
P
K
R
LV
N
F
E
KVDQPA
A
H
E
I
F
L
RDALTTGNLGTV
P
P
F
L
K
H
N
L
L
K
L
E
E
V
E
R
V
E
D
K
L
R
RRDLVV
D
E
E
T
I
Y
Q
F
Y
E
S
KI
P
E
E
I
A
SRR
S
F
E
D
W
R
A
TVEAKNP
R
Y
L
Y
VED
D
A
L
WLNDRP
T
T
Q
Q
F
P
D
HLHNG
Q
L
R
L
A
T
T
Y
RFDPSHDEDG
A
T
V
Q
I
P
V
Q
ALPQVDE
N
I
WSWGIPG
W
R
L
D
L
I
E
A
L
L
K
AL
P
K
D
KRRNLVPI
P
D
T
A
R
K
L
M
Q
G
I
D
A
V
H
L
R
Q
H
I
F
S
Y
L
A
F
A
LRGEQITDKDFSFERI
D
P
Y
L
V
P
F
I
K
V
IDEKG
K
L
I
AKGR
D
L
A
E
L
K
A
R
CRVETHR
P
V
K
Q
QKGEFKTFPEN
F
T
FEASQK
V
T
G
V
V
V
K
Q
Y
Q
A
LVPTKN
F
A
E
L
EAKDES
G
V
V
I
Q
TFN
D
Q
A
E
A
I
K
Q
H
R
E
G
I
I
R
L
V
H
M
Q
L
G
D
L
V
R
Q
L
K
K
Q
I
SKP
L
A
L
A
YSPLG
D
K
A
K
L
E
Q
M
L
V
Y
A
T
L
Q
M
A
I
T
TLPI
N
A
D
E
F
N
K
L
L
D
Q
V
K
K
Q
F
L
S
Y
G
Q
Q
A
L
E
Q
L
G
D
I
Y
I
Q
W
Q
Q
I
R
R
Q
L
L
VL
D
P
D
V
FGR
S
I
D
D
I
E
D
Q
L
D
L
M
SLG
N
F
V
Y
C
Q
P
V
D
L
W
Q
E
Y
P
R
Y
L
K
A
L
L
L
R
L
D
RLP
N
N
L
Q
R
D
HAAIDDV
D
P
W
M
D
K
V
F
KFKNDP
R
I
K
E
L
Y
L
M
L
E
E
L
R
I
S
L
FSQPMKTKMPI
S
P
T
R
L
Q
K
L
W
D
RLGIS
28
Fugue
74.39
30%
24
- C3 -
-
5AOR
3
MLE_DROME
A:
[119-1158]
LGEAYRPLEQ
R
D
M
N
E
A
E
A
FDVNAAIHGNWTIEN
A
K
E
R
L
N
I
Y
K
Q
T
N
NIRD
D
Y
K
Y
T
P
V
G
P
EHA
R
S
F
L
A
E
L
S
I
Y
V
PALN
R
T
V
T
A
R
E
S
G
SN
K
K
S
A
S
K
S
C
A
L
S
L
V
R
Q
L
F
H
L
NVIEPFS
G
T
L
K
KDEQL
K
P
Y
P
V
K
L
S
P
N
L
I
N
K
I
D
E
V
I
K
G
L
D
L
-----------
P
V
V
N
P
R
N
I
K
I
E
L
D
GPPIPLIVNLSRIESSVI
P
W
A
P
P
QANWNTWHA
C
N
I
D
E
G
E
L
A
-------------------
T
T
S
I
D
D
L
S
M
D
Y
E
---
R
S
L
R
D
R
R
Q
N
D
N
E
Y
R
Q
F
L
E
F
R
E
K
L
P
I
A
A
M
R
S
E
I
L
T
A
I
N
D
N
P
V
V
I
I
R
G
N
T
G
C
G
K
T
T
Q
I
A
Q
Y
I
L
D
D
Y
I
C
--
S
G
Q
---
G
G
Y
--
A
---
N
I
Y
V
T
Q
P
R
R
I
S
A
I
S
V
A
E
R
V
A
R
E
R
C
E
Q
L
G
D
T
V
G
Y
S
V
R
F
E
S
V
F
P
R
P
Y
G
A
I
L
F
C
T
V
G
V
L
L
R
K
L
E
A
G
L
R
G
V
S
---
H
I
I
V
D
E
I
H
E
R
D
V
N
S
D
F
L
L
V
I
L
R
D
M
V
D
T
Y
P
D
L
H
V
I
L
M
S
A
T
I
D
T
T
K
F
S
K
Y
F
G
I
C
P
V
L
E
V
P
G
R
A
F
P
V
Q
Q
F
F
L
E
D
I
I
Q
M
T
D
F
V
P
S
A
E
S
R
R
K
R
K
E
V
E
-
D
E
E
Q
L
L
S
EDKDEAEINYNKVCEDKYS
Q
K
T
R
N
A
M
A
M
LSESDVS
F
E
L
L
E
A
L
L
M
H
I
K
S
K
N
-
I
-
P
G
--
A
I
L
V
F
L
P
G
W
N
L
I
F
--------
A
L
M
K
F
L
----
Q
N
----
T
N
IFGD----
T
------
S
--
Q
Y
Q
--------
I
L
P
C
H
S
Q
I
P
R
D
E
Q
R
K
V
F
E
-------
P
-------
V
P
E
------
G
V
------
T
-
K
I
I
L
S
T
N
I
A
E
T
S
I
T
I
D
D
I
V
F
V
I
D
I
C
K
A
R
M
K
L
F
T
S
H
N
N
L
T
S
Y
A
T
V
W
A
S
K
T
N
L
E
Q
R
K
G
R
A
G
R
V
R
P
G
F
C
F
T
L
C
S
R
A
R
F
Q
-
A
-
L
-
E
-
D
N
L
T
P
E
M
F
R
T
P
L
H
E
M
A
L
T
I
K
L
L
R
L
G
S
I
H
H
F
L
S
K
A
L
E
P
P
P
V
D
A
V
I
E
A
E
V
L
L
R
E
M
R
C
L
D
A
N
-
D
E
L
T
P
L
G
R
L
L
A
R
L
P
I
E
P
R
L
G
K
M
M
V
L
G
A
V
F
G
C
A
D
L
M
A
I
M
A
S
Y
S
S
T
F
S
E
V
F
S
L
D
I
G
Q
R
R
L
A
N
H
Q
K
A
L
S
G
T
K
C
S
D
H
V
A
M
I
V
A
S
Q
M
W
R
R
E
K
Q
R
G
-------
E
H
M
E
A
R
F
C
D
W
K
G
L
Q
--------------------------------------------------------------------------------------------------------------------------------------
M
S
T
M
N
V
I
W
D
A
K
Q
Q
L
L
D
L
L
Q
Q
-------------------------------------------------------------------------------
A
G
F
P
E
E
C
M
--------------------------------------------------
I
S
H
E
V
D
E
R
I
D
G
D
D
-----------------------------------------------------------------
P
V
L
D
V
S
L
A
L
L
C
L
G
----------------
L
Y
P
N
I
C
V
H
K
E
K
R
K
V
L
T
T
E
S
K
A
A
L
L
--------
H
K
T
S
V
N
C
S
N
L
A
V
T
F
P
Y
P
F
F
V
F
G
E
K
I
R
T
R
A
V
S
C
K
Q
L
S
M
V
S
---------------
P
L
Q
V
I
L
F
G
S
R
K
I
D
L
A
A
N
N
I
V
R
V
D
N
W
--------
L
N
F
D
I
E
P
E
L
A
A
K
I
G
A
L
--
K
P
A
L
E
D
L
I
T
V
A
C
D
----------------------------
N
P
S
D
I
L
R
L
E
E
P
Y
A
Q
L
V
K
V
V
K
D
L
C
V
K
S
A
G
D
F
G
-----------------------------------------------
L
Q
R
----------------------------------------------------------------
6
PsiBlast_PDB
70.61
36%
-34
- C3 -
-
5MQ0
-
PRP22_YEAST
V:
[476-1115]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
A
Q
R
Q
T
L
P
V
Y
A
M
R
S
E
L
I
Q
A
V
R
D
N
Q
F
L
V
I
V
G
E
T
G
S
G
K
T
T
Q
I
T
Q
Y
L
D
----
E
--
E
G
F
---
S
N
Y
--
G
---
M
I
G
C
T
Q
P
R
R
V
A
A
V
S
V
A
K
R
V
A
E
E
V
G
C
K
V
G
H
D
V
G
Y
T
I
R
F
E
D
V
T
G
P
D
T
-
R
I
K
Y
M
T
D
G
M
L
Q
R
E
A
L
L
D
-
P
E
M
S
K
Y
S
V
I
M
L
D
E
A
H
E
R
T
V
A
T
D
V
L
F
A
L
L
K
K
A
A
I
K
R
P
E
L
K
V
I
V
T
S
A
T
L
N
S
A
K
F
S
E
Y
F
L
N
C
P
I
I
N
I
P
G
K
T
F
P
V
E
V
-
L
Y
S
Q
T
P
Q
M
------
D
------------------------------------------
Y
I
E
A
----------
A
L
D
C
V
I
D
I
H
I
N
E
-
G
-
P
--
G
D
I
L
V
F
L
T
G
Q
E
E
I
D
--------
S
C
C
E
I
L
YDRV
K
T
----
L
G
--------
D
------
S
--
I
G
E
LL------
I
L
P
V
Y
S
A
L
P
S
E
I
Q
S
K
I
F
E
-------
P
-------
T
P
K
------
G
S------
R
-
K
V
V
F
A
T
N
I
A
E
T
S
I
T
I
D
G
I
Y
Y
V
V
D
P
G
F
A
K
I
N
I
Y
N
A
R
A
G
I
E
Q
L
I
V
S
P
I
S
Q
A
Q
A
N
Q
R
K
G
R
A
G
R
T
G
P
G
K
C
Y
R
L
Y
T
E
S
A
F
Y
-
N
-
E
-
M
L
E
N
T
V
P
E
I
Q
R
Q
N
L
S
H
T
I
L
M
L
K
A
M
G
I
N
D
L
L
K
F
D
--
F
M
D
P
P
P
K
N
L
M
L
N
A
L
T
E
L
Y
H
L
Q
S
L
D
D
-
E
G
K
L
T
N
L
G
K
E
M
S
L
F
P
M
D
P
T
L
S
R
S
L
L
S
S
V
D
N
Q
C
S
D
E
I
V
T
I
I
S
M
L
S
V
Q
N
V
F
Y
R
P
K
D
R
Q
L
E
-
A
D
S
K
K
A
K
F
H
H
P
Y
G
D
H
L
T
L
L
N
V
Y
T
R
W
Q
---
Q
A
N
Y
S
E
----
Q
Y
C
K
T
N
F
L
H
F
R
H
L
K
R
A
R
D
V
K
S
Q
I
S
M
I
F
K
K
I
G
L
-----
K
L
----
I
----
S
----
C
H
S
D
----
P
D
L
I
R
K
T
F
V
S
G
F
F
-
M
N
A
-
A
K
R
D
S
-
Q
V
G
Y
K
T
-
I
N
G
G
T
E
V
G
I
H
P
S
S
S
L
Y
----
E
Y
V
M
Y
H
S
I
V
L
T
S
R
E
Y
M
S
Q
V
T
S
I
E
P
Q
W
L
L
E
V
A
P
H
F
Y
K
A
G
D
A
E
S
Q
S
R
K
K
A
K
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
69.70
37%
-35
- C3 -
-
5MQ0
-
PRP22_YEAST
V:
[477-1104]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
Q
R
Q
T
L
P
V
Y
A
M
R
S
E
L
I
Q
A
V
R
D
N
Q
F
L
V
I
V
G
E
T
G
S
G
K
T
T
Q
I
T
Q
Y
L
D
----
E
--
E
G
F
---
S
N
Y
--
G
---
M
I
G
C
T
Q
P
R
R
V
A
A
V
S
V
A
K
R
V
A
E
E
V
G
C
K
V
G
H
D
V
G
Y
T
I
R
F
E
D
V
T
G
P
D
T
-
R
I
K
Y
M
T
D
G
M
L
Q
R
E
A
L
L
D
-
P
E
M
S
K
Y
S
V
I
M
L
D
E
A
H
E
R
T
V
A
T
D
V
L
F
A
L
L
K
K
A
A
I
K
R
P
E
L
K
V
I
V
T
S
A
T
L
N
S
A
K
F
S
E
Y
F
L
N
C
P
I
I
N
I
P
G
K
T
F
P
V
E
V
-
L
Y
S
Q
T
P
Q
M
------
D
---------------------------------------------
Y
----------
I
E
A
A
L
D
C
V
I
D
I
H
I
N
-
E
G
P
G
D
I
L
V
F
L
T
G
Q
E
E
I
D
--------
S
C
C
E
I
L
----
Y
D
----
R
V
KTLGDS--
I
------
G
--
E
L
L
--------
I
L
P
V
Y
S
A
L
P
S
E
I
Q
S
K
I
F
E
-------
P
-------
T
P
K
------
G
-------
S
R
K
V
V
F
A
T
N
I
A
E
T
S
I
T
I
D
G
I
Y
Y
V
V
D
P
G
F
A
K
I
N
I
Y
N
A
R
A
G
I
E
Q
L
I
V
S
P
I
S
Q
A
Q
A
N
Q
R
K
G
R
A
G
R
T
G
P
G
K
C
Y
R
L
Y
T
E
S
A
F
Y
N
E
-
M
-
L
-
E
N
T
V
P
E
I
Q
R
Q
N
L
S
H
T
I
L
M
L
K
A
M
G
I
N
D
L
L
K
F
D
--
F
M
D
P
P
P
K
N
L
M
L
N
A
L
T
E
L
Y
H
L
Q
S
L
D
D
E
-
G
K
L
T
N
L
G
K
E
M
S
L
F
P
M
D
P
T
L
S
R
S
L
L
S
S
V
D
N
Q
C
S
D
E
I
V
T
I
I
S
M
L
S
V
Q
N
V
F
Y
R
P
K
D
R
Q
L
E
-
A
D
S
K
K
A
K
F
H
H
P
Y
G
D
H
L
T
L
L
N
V
Y
T
R
W
Q
Q
-
A
N
------
Y
S
E
Q
Y
C
K
T
N
F
L
H
F
R
H
L
K
R
A
R
D
V
K
S
Q
I
S
M
I
F
K
K
I
G
L
-----
K
L
----
I
----
S
----
C
H
S
D
----
P
D
L
I
R
K
T
F
V
S
G
F
F
M
N
A
A
-
K
R
D
S
Q
-
V
G
Y
K
T
I
-
N
G
-
G
T
E
V
G
I
H
P
S
S
S
L
Y
----
E
Y
V
M
Y
H
S
I
V
L
T
S
R
E
Y
M
S
Q
V
T
S
I
E
P
Q
W
L
L
E
V
A
P
H
F
Y
K
A
G
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
66.31
36%
-7
- C3 -
-
5XDR
1
?
A:
[32-657]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
W
E
Y
K
D
R
F
T
D
I
L
V
R
H
Q
S
F
V
L
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
W
C
V
----
E
--
Y
M
R
---
S
L
P
--
G
P
K
R
G
V
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
D
E
M
D
V
M
L
G
Q
E
V
G
Y
S
I
R
F
E
D
C
S
S
A
K
T
-
I
L
K
Y
M
T
D
G
M
L
L
R
E
A
M
N
D
-
P
L
L
E
R
Y
G
V
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
G
V
L
K
E
V
V
R
Q
R
S
D
L
K
V
I
V
M
S
A
T
L
D
A
G
K
F
Q
I
Y
F
D
N
C
P
L
L
T
I
P
G
R
T
H
P
V
E
I
-
F
Y
T
P
E
P
E
R
------------------
D
Y
L
E
A
A
I
----------------------
R
T
V
I
Q
-----------
I
H
M
C
---
E
E
E
E
G
-------
D
L
L
L
F
L
T
G
Q
E
E
I
D
--------
E
A
C
K
R
I
----
K
R
EVDD
L
G
--------
P
------
E
VG
D
I
K
--------
I
I
P
L
Y
S
T
L
P
P
Q
Q
Q
Q
R
I
F
E
-------
P
PPPKKQN
G
A
I
------
G
-------
R
-
K
V
V
V
S
T
N
I
A
E
T
S
L
T
I
D
G
V
V
F
V
I
D
P
G
F
A
K
Q
K
V
Y
N
P
R
I
R
V
E
S
L
L
V
T
A
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
K
A
Y
K
-
T
-
E
M
Q
-
D
N
T
Y
P
E
I
L
R
S
N
L
G
S
V
V
L
Q
L
K
K
L
G
I
D
D
L
V
H
F
D
--
F
M
D
P
P
A
P
E
T
L
M
R
A
L
E
L
L
N
Y
L
A
A
L
N
D
-
D
G
D
L
T
E
L
G
S
M
M
A
E
F
P
L
D
P
Q
L
A
K
M
V
I
A
S
C
D
Y
N
C
S
N
E
V
L
S
I
T
A
M
L
S
V
P
Q
C
F
V
R
P
T
E
A
K
K
A
-
A
D
E
A
K
M
R
F
A
H
I
D
G
D
H
L
T
L
L
N
V
Y
H
A
F
K
Q
N
H
E
S
-------
V
Q
W
C
Y
D
N
F
I
N
Y
R
S
L
M
S
A
D
N
V
R
Q
Q
L
S
R
I
M
D
R
F
N
L
PRRSS
D
F
----
T
----
S
----
R
-
D
Y
----
Y
I
N
I
R
K
A
L
V
T
G
Y
F
M
Q
V
A
-
H
-
L
E
R
-
T
G
H
Y
L
T
-
V
K
-
D
N
Q
V
V
Q
L
H
P
S
T
V
L
D
H
K
P
E
W
V
L
Y
N
E
F
V
L
T
T
K
N
Y
I
R
T
C
T
D
I
K
P
E
W
L
V
K
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
66.17
37%
1
- C3 -
-
5XDR
1
?
A:
[27-671]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
R
L
Q
L
P
V
W
E
Y
K
D
R
F
T
D
I
L
V
R
H
Q
S
F
V
L
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
W
C
V
----
E
--
Y
M
R
S
LP
G
P
K
--
R
---
G
V
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
D
E
M
D
V
M
L
G
Q
E
V
G
Y
S
I
R
F
E
D
C
S
S
A
K
T
-
I
L
K
Y
M
T
D
G
M
L
L
R
E
A
M
N
D
-
P
L
L
E
R
Y
G
V
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
G
V
L
K
E
V
V
R
Q
R
S
D
L
K
V
I
V
M
S
A
T
L
D
A
G
K
F
Q
I
Y
F
D
N
C
P
L
L
T
I
P
G
R
T
H
P
V
E
I
-
F
Y
T
P
E
P
E
R
------
D
Y
-----------------------------------------
L
E
A
A
----------
I
R
T
V
I
Q
I
H
M
C
---
E
-
E
E
E
G
D
L
L
L
F
L
T
G
Q
E
E
I
D
--------
E
A
C
K
R
I
----
K
R
----
E
V
--------
D
DLGPEV
G
--
D
I
K
--------
I
I
P
L
Y
S
T
L
P
P
Q
Q
Q
Q
R
I
F
E
-------
P
-------
P
P
P
------
K
KQNGAIG
R
-
K
V
V
V
S
T
N
I
A
E
T
S
L
T
I
D
G
V
V
F
V
I
D
P
G
F
A
K
Q
K
V
Y
N
P
R
I
R
V
E
S
L
L
V
T
A
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
K
A
Y
K
-
T
E
M
-
Q
-
D
N
T
Y
P
E
I
L
R
S
N
L
G
S
V
V
L
Q
L
K
K
L
G
I
D
D
L
V
H
F
D
--
F
M
D
P
P
A
P
E
T
L
M
R
A
L
E
L
L
N
Y
L
A
A
L
N
D
D
-
G
D
L
T
E
L
G
S
M
M
A
E
F
P
L
D
P
Q
L
A
K
M
V
I
A
S
C
D
Y
N
C
S
N
E
V
L
S
I
T
A
M
L
S
V
P
Q
C
F
V
R
P
T
E
A
K
K
A
-
A
D
E
A
K
M
R
F
A
H
I
D
G
D
H
L
T
L
L
N
V
Y
H
A
F
K
Q
-
N
H
------
E
S
V
Q
W
C
Y
D
N
F
I
N
Y
R
S
L
M
S
A
D
N
V
R
Q
Q
L
S
R
I
M
D
R
F
N
L
-----
P
R
----
R
----
S
SDFT
S
R
D
Y
----
Y
I
N
I
R
K
A
L
V
T
G
Y
F
M
Q
V
A
-
H
L
E
R
T
--
G
H
Y
L
T
V
K
D
-
N
Q
V
V
Q
L
H
P
S
T
V
L
D
-
H
K
P
E
W
V
L
Y
N
E
F
V
L
T
T
K
N
Y
I
R
T
C
T
D
I
K
P
E
W
L
V
K
I
A
P
Q
Y
Y
D
M
S
N
F
P
Q
C
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
66.13
36%
11
- C3 -
-
3KX2
1
PRP43_YEAST
A:
[87-719]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
R
R
E
L
P
V
H
A
Q
R
D
E
F
L
K
L
Y
Q
N
N
Q
I
M
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
F
V
L
----
F
D
E
M
P
H
---
L
E
N
--
T
---
Q
V
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
E
E
M
D
V
K
L
G
E
E
V
G
Y
S
I
R
F
E
N
K
T
S
N
K
T
-
I
L
K
Y
M
T
D
G
M
L
L
R
E
A
M
E
D
-
H
D
L
S
R
Y
S
C
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
G
L
L
K
Q
V
V
K
R
R
P
D
L
K
I
I
I
M
S
A
T
L
D
A
E
K
F
Q
R
Y
F
N
D
A
P
L
L
A
V
P
G
R
T
Y
P
V
E
L
-
Y
Y
T
P
------------------
E
F
Q
R
D
Y
L
D
S
A
I
----------------------
R
T
V
L
Q
---------------
I
H
A
T
E
E
A
G
-------
D
I
L
L
F
L
T
G
E
D
E
I
E
D
A
V
R
K
I
S
L
E
G
D
Q
L
V
----
R
E
----
E
G
--------
C
------
G
--
P
L
S
--------
V
Y
P
L
Y
G
S
L
P
P
H
Q
Q
Q
R
I
F
E
-------
P
-------
A
P
E
SHNG
R
P
G
-------
R
-
K
V
V
I
S
T
N
I
A
E
T
S
L
T
I
D
G
I
V
Y
V
V
D
P
G
F
S
K
Q
K
V
Y
N
P
R
I
R
V
E
S
L
L
V
S
P
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
E
A
F
Q
-
K
-
E
L
I
-
E
Q
S
Y
P
E
I
L
R
S
N
L
S
S
T
V
L
E
L
K
K
L
G
I
D
D
L
V
H
F
D
--
F
M
D
P
P
A
P
E
T
M
M
R
A
L
E
E
L
N
Y
L
A
C
L
D
D
E
G
N
-
L
T
P
L
G
R
L
A
S
Q
F
P
L
D
P
M
L
A
V
M
L
I
G
S
F
E
F
Q
C
S
Q
E
I
L
T
I
V
A
M
L
S
V
P
N
V
F
I
R
P
T
K
D
K
K
R
-
A
D
D
A
K
N
I
F
A
H
P
D
G
D
H
I
T
L
L
N
V
Y
H
A
F
K
-
S
D
E
A
--
Y
E
Y
G
I
H
K
W
C
R
D
H
Y
L
N
Y
R
S
L
S
A
A
D
N
I
R
S
Q
L
E
R
L
M
N
R
Y
N
L
-----
E
L
----
N
T
T
DY
E
----
S
P
K
Y
----
F
D
N
I
R
K
A
L
A
S
G
F
F
M
Q
V
A
-
K
K
R
S
G
-
A
K
G
Y
I
T
-
V
K
-
D
N
Q
D
V
L
I
H
P
S
T
V
L
G
H
D
A
E
W
V
I
Y
N
E
F
V
L
T
S
K
N
Y
I
R
T
V
T
S
V
R
P
E
W
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
66.02
36%
11
- C3 -
-
3KX2
1
PRP43_YEAST
B:
[87-719]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
R
R
E
L
P
V
H
A
Q
R
D
E
F
L
K
L
Y
Q
N
N
Q
I
M
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
F
V
L
----
F
DE
M
P
H
---
L
E
N
--
T
---
Q
V
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
E
E
M
D
V
K
L
G
E
E
V
G
Y
S
I
R
F
E
N
K
T
S
N
K
T
-
I
L
K
Y
M
T
D
G
M
L
L
R
E
A
M
E
D
-
H
D
L
S
R
Y
S
C
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
G
L
L
K
Q
V
V
K
R
R
P
D
L
K
I
I
I
M
S
A
T
L
D
A
E
K
F
Q
R
Y
F
N
D
A
P
L
L
A
V
P
G
R
T
Y
P
V
E
L
-
Y
Y
T
P
------------------
E
F
Q
R
D
Y
L
D
S
A
I
----------------------
R
T
V
L
Q
---------------
I
H
A
T
E
E
A
G
-------
D
I
L
L
F
L
T
G
E
D
E
I
E
DAVRKISL
E
G
D
Q
L
V
----
R
E
----
E
G
--------
C
------
G
--
P
L
S
--------
V
Y
P
L
Y
G
S
L
P
P
H
Q
Q
Q
R
I
F
E
-------
P
-------
A
P
E
SHNGRP
G
-------
R
-
K
V
V
I
S
T
N
I
A
E
T
S
L
T
I
D
G
I
V
Y
V
V
D
P
G
F
S
K
Q
K
V
Y
N
P
R
I
R
V
E
S
L
L
V
S
P
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
E
A
F
Q
-
K
-
E
L
I
-
E
Q
S
Y
P
E
I
L
R
S
N
L
S
S
T
V
L
E
L
K
K
L
G
I
D
D
L
V
H
F
D
--
F
M
D
P
P
A
P
E
T
M
M
R
A
L
E
E
L
N
Y
L
A
C
L
D
D
E
G
N
-
L
T
P
L
G
R
L
A
S
Q
F
P
L
D
P
M
L
A
V
M
L
I
G
S
F
E
F
Q
C
S
Q
E
I
L
T
I
V
A
M
L
S
V
P
N
V
F
I
R
P
T
K
D
K
K
R
-
A
D
D
A
K
N
I
F
A
H
P
D
G
D
H
I
T
L
L
N
V
Y
H
A
F
K
-
S
D
E
A
--
Y
E
Y
G
I
H
K
W
C
R
D
H
Y
L
N
Y
R
S
L
S
A
A
D
N
I
R
S
Q
L
E
R
L
M
N
R
Y
N
L
-----
E
L
----
N
TTDY
E
----
S
P
K
Y
----
F
D
N
I
R
K
A
L
A
S
G
F
F
M
Q
V
A
-
K
K
R
S
G
-
A
K
G
Y
I
T
-
V
K
-
D
N
Q
D
V
L
I
H
P
S
T
V
L
G
H
D
A
E
W
V
I
Y
N
E
F
V
L
T
S
K
N
Y
I
R
T
V
T
S
V
R
P
E
W
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
65.96
36%
9
- C3 -
-
5JPT
1
PRP43_YEAST
B:
[87-719]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
R
R
E
L
P
V
H
A
Q
R
D
E
F
L
K
L
Y
Q
N
N
Q
I
M
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
F
V
L
----
F
DE
M
P
H
---
L
E
N
--
T
---
Q
V
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
E
E
M
D
V
K
L
G
E
E
V
G
Y
S
I
R
F
E
N
K
T
S
N
K
T
-
I
L
K
Y
M
T
D
G
M
L
L
R
E
A
M
E
D
-
H
D
L
S
R
Y
S
C
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
G
L
L
K
Q
V
V
K
R
R
P
D
L
K
I
I
I
M
S
A
T
L
D
A
E
K
F
Q
R
Y
F
N
D
A
P
L
L
A
V
P
G
R
T
Y
P
V
E
L
-
Y
Y
T
P
------------------
E
F
Q
R
D
Y
L
D
S
A
I
----------------------
R
T
V
L
Q
---------------
I
H
A
T
E
E
A
G
-------
D
I
L
L
F
L
T
G
E
D
E
I
E
DAVRKISL
E
G
D
Q
L
V
----
R
E
----
E
G
--------
C
------
G
--
P
L
S
--------
V
Y
P
L
Y
G
S
L
P
P
H
Q
Q
Q
R
I
F
E
-------
P
-------
A
P
E
SHNGRP
G
-------
R
-
K
V
V
I
S
T
N
I
A
E
T
S
L
T
I
D
G
I
V
Y
V
V
D
P
G
F
S
K
Q
K
V
Y
N
P
R
I
R
V
E
S
L
L
V
S
P
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
E
A
F
Q
-
K
-
E
L
I
-
E
Q
S
Y
P
E
I
L
R
S
N
L
S
S
T
V
L
E
L
K
K
L
G
I
D
D
L
V
H
F
D
--
F
M
D
P
P
A
P
E
T
M
M
R
A
L
E
E
L
N
Y
L
A
C
L
D
D
E
G
N
-
L
T
P
L
G
R
L
A
S
Q
F
P
L
D
P
M
L
A
V
M
L
I
G
S
F
E
F
Q
C
S
Q
E
I
L
T
I
V
A
M
L
S
V
P
N
V
F
I
R
P
T
K
D
K
K
R
-
A
D
D
A
K
N
I
F
A
H
P
D
G
D
H
I
T
L
L
N
V
Y
H
A
F
K
-
S
D
E
A
--
Y
E
Y
G
I
H
K
W
C
R
D
H
Y
L
N
Y
R
S
L
S
A
A
D
N
I
R
S
Q
L
E
R
L
M
N
R
Y
N
L
-----
E
L
----
N
TTDY
E
----
S
P
K
Y
----
F
D
N
I
R
K
A
L
A
S
G
F
F
M
Q
V
A
-
K
K
R
-----
G
Y
I
T
-
V
K
-
D
N
Q
D
V
L
I
H
P
S
T
V
L
G
H
D
A
E
W
V
I
Y
N
E
F
V
L
T
S
K
N
Y
I
R
T
V
T
S
V
R
P
E
W
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
65.92
36%
14
- C3 -
-
5JPT
2
PRP43_YEAST
A:
[87-719]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
R
R
E
L
P
V
H
A
Q
R
D
E
F
L
K
L
Y
Q
N
N
Q
I
M
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
F
V
L
----
F
D
E
M
P
H
---
L
E
N
--
T
---
Q
V
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
E
E
M
D
V
K
L
G
E
E
V
G
Y
S
I
R
F
E
N
K
T
S
N
K
T
-
I
L
K
Y
M
T
D
G
M
L
L
R
E
A
M
E
D
-
H
D
L
S
R
Y
S
C
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
G
L
L
K
Q
V
V
K
R
R
P
D
L
K
I
I
I
M
S
A
T
L
D
A
E
K
F
Q
R
Y
F
N
D
A
P
L
L
A
V
P
G
R
T
Y
P
V
E
L
-
Y
Y
T
P
------------------
E
F
Q
R
D
Y
L
D
S
A
I
----------------------
R
T
V
L
Q
---------------
I
H
A
T
E
E
A
G
-------
D
I
L
L
F
L
T
G
E
D
E
I
E
D
A
V
R
K
I
S
L
E
G
D
Q
L
V
----
R
E
----
E
G
--------
C
------
G
--
P
L
S
--------
V
Y
P
L
Y
G
S
L
P
P
H
Q
Q
Q
R
I
F
E
-------
P
-------
A
P
E
SHNG
R
P
G
-------
R
-
K
V
V
I
S
T
N
I
A
E
T
S
L
T
I
D
G
I
V
Y
V
V
D
P
G
F
S
K
Q
K
V
Y
N
P
R
I
R
V
E
S
L
L
V
S
P
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
E
A
F
Q
-
K
-
E
L
I
-
E
Q
S
Y
P
E
I
L
R
S
N
L
S
S
T
V
L
E
L
K
K
L
G
I
D
D
L
V
H
F
D
--
F
M
D
P
P
A
P
E
T
M
M
R
A
L
E
E
L
N
Y
L
A
C
L
D
D
E
G
N
-
L
T
P
L
G
R
L
A
S
Q
F
P
L
D
P
M
L
A
V
M
L
I
G
S
F
E
F
Q
C
S
Q
E
I
L
T
I
V
A
M
L
S
V
P
N
V
F
I
R
P
T
K
D
K
K
R
-
A
D
D
A
K
N
I
F
A
H
P
D
G
D
H
I
T
L
L
N
V
Y
H
A
F
K
-
S
D
E
A
--
Y
E
Y
G
I
H
K
W
C
R
D
H
Y
L
N
Y
R
S
L
S
A
A
D
N
I
R
S
Q
L
E
R
L
M
N
R
Y
N
L
-----
E
L
----
N
T
T
DY
E
----
S
P
K
Y
----
F
D
N
I
R
K
A
L
A
S
G
F
F
M
Q
V
A
-
K
K
R
S
G
---
G
Y
I
T
-
V
K
-
D
N
Q
D
V
L
I
H
P
S
T
V
L
G
H
D
A
E
W
V
I
Y
N
E
F
V
L
T
S
K
N
Y
I
R
T
V
T
S
V
R
P
E
W
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
65.76
36%
9
- C3 -
-
2XAU
2
PRP43_YEAST
B:
[87-719]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
R
R
E
L
P
V
H
A
Q
R
D
E
F
L
K
L
Y
Q
N
N
Q
I
M
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
F
V
L
----
F
DE
M
P
H
---
L
E
N
--
T
---
Q
V
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
E
E
M
D
V
K
L
G
E
E
V
G
Y
S
I
R
F
E
N
K
T
S
N
K
T
-
I
L
K
Y
M
T
D
G
M
L
L
R
E
A
M
E
D
-
H
D
L
S
R
Y
S
C
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
G
L
L
K
Q
V
V
K
R
R
P
D
L
K
I
I
I
M
S
A
T
L
D
A
E
K
F
Q
R
Y
F
N
D
A
P
L
L
A
V
P
G
R
T
Y
P
V
E
L
-
Y
Y
T
P
------------------
E
F
Q
R
D
Y
L
D
S
A
I
----------------------
R
T
V
L
Q
---------------
I
H
A
T
E
E
A
G
-------
D
I
L
L
F
L
T
G
E
D
E
I
E
DAVRKISL
E
G
D
Q
L
V
----
R
E
----
E
G
--------
C
------
G
--
P
L
S
--------
V
Y
P
L
Y
G
S
L
P
P
H
Q
Q
Q
R
I
F
E
-------
P
-------
A
P
E
SHNGRP
G
-------
R
-
K
V
V
I
S
T
N
I
A
E
T
S
L
T
I
D
G
I
V
Y
V
V
D
P
G
F
S
K
Q
K
V
Y
N
P
R
I
R
V
E
S
L
L
V
S
P
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
E
A
F
Q
-
K
-
E
L
I
-
E
Q
S
Y
P
E
I
L
R
S
N
L
S
S
T
V
L
E
L
K
K
L
G
I
D
D
L
V
H
F
D
--
F
M
D
P
P
A
P
E
T
M
M
R
A
L
E
E
L
N
Y
L
A
C
L
D
D
E
G
N
-
L
T
P
L
G
R
L
A
S
Q
F
P
L
D
P
M
L
A
V
M
L
I
G
S
F
E
F
Q
C
S
Q
E
I
L
T
I
V
A
M
L
S
V
P
N
V
F
I
R
P
T
K
D
K
K
R
-
A
D
D
A
K
N
I
F
A
H
P
D
G
D
H
I
T
L
L
N
V
Y
H
A
F
K
-
S
D
E
A
--
Y
E
Y
G
I
H
K
W
C
R
D
H
Y
L
N
Y
R
S
L
S
A
A
D
N
I
R
S
Q
L
E
R
L
M
N
R
Y
N
L
-----
E
L
----
N
TTDY
E
----
S
P
K
Y
----
F
D
N
I
R
K
A
L
A
S
G
F
F
M
Q
V
A
-
K
K
R
-----
G
Y
I
T
-
V
K
-
D
N
Q
D
V
L
I
H
P
S
T
V
L
G
H
D
A
E
W
V
I
Y
N
E
F
V
L
T
S
K
N
Y
I
R
T
V
T
S
V
R
P
E
W
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
65.67
36%
11
- C3 -
-
5I8Q
2
PRP43_YEAST
B:
[87-719]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
R
R
E
L
P
V
H
A
Q
R
D
E
F
L
K
L
Y
Q
N
N
Q
I
M
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
F
V
L
----
F
DE
M
P
H
---
L
E
N
--
T
---
Q
V
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
E
E
M
D
V
K
L
G
E
E
V
G
Y
S
I
R
F
E
N
K
T
S
N
K
T
-
I
L
K
Y
M
T
D
G
M
L
L
R
E
A
M
E
D
-
H
D
L
S
R
Y
S
C
I
I
L
D
E
A
H
E
R
T
L
A
T
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I
L
M
G
L
L
K
Q
V
V
K
R
R
P
D
L
K
I
I
I
M
S
A
T
L
D
A
E
K
F
Q
R
Y
F
N
D
A
P
L
L
A
V
P
G
R
T
Y
P
V
E
L
-
Y
Y
T
P
------------------
E
F
Q
R
D
Y
L
D
S
A
I
----------------------
R
T
V
L
Q
---------------
I
H
A
T
E
E
A
G
-------
D
I
L
L
F
L
T
G
E
D
E
I
E
DAVRKISL
E
G
D
Q
L
V
----
R
E
----
E
G
--------
C
------
G
--
P
L
S
--------
V
Y
P
L
Y
G
S
L
P
P
H
Q
Q
Q
R
I
F
E
-------
P
-------
A
P
E
SHNGRP
G
-------
R
-
K
V
V
I
S
T
N
I
A
E
T
S
L
T
I
D
G
I
V
Y
V
V
D
P
G
F
S
K
Q
K
V
Y
N
P
R
I
R
V
E
S
L
L
V
S
P
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
E
A
F
Q
-
K
-
E
L
I
-
E
Q
S
Y
P
E
I
L
R
S
N
L
S
S
T
V
L
E
L
K
K
L
G
I
D
D
L
V
H
F
D
--
F
M
D
P
P
A
P
E
T
M
M
R
A
L
E
E
L
N
Y
L
A
C
L
D
D
E
G
N
-
L
T
P
L
G
R
L
A
S
Q
F
P
L
D
P
M
L
A
V
M
L
I
G
S
F
E
F
Q
C
S
Q
E
I
L
T
I
V
A
M
L
S
V
P
N
V
F
I
R
P
T
K
D
K
K
R
-
A
D
D
A
K
N
I
F
A
H
P
D
G
D
H
I
T
L
L
N
V
Y
H
A
F
K
-
S
D
E
A
--
Y
E
Y
G
I
H
K
W
C
R
D
H
Y
L
N
Y
R
S
L
S
A
A
D
N
I
R
S
Q
L
E
R
L
M
N
R
Y
N
L
-----
E
L
----
N
TTDY
E
----
S
P
K
Y
----
F
D
N
I
R
K
A
L
A
S
G
F
F
M
Q
V
A
-
K
K
R
S
G
-
A
K
G
Y
I
T
-
V
K
-
D
N
Q
D
V
L
I
H
P
S
T
V
L
G
H
D
A
E
W
V
I
Y
N
E
F
V
L
T
S
K
N
Y
I
R
T
V
T
S
V
R
P
E
W
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
65.62
36%
22
- C3 -
-
5LTA
2
?
A:
[38-692]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
N
K
Q
R
Q
E
F
L
D
L
Y
H
N
N
Q
I
L
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
V
L
----
Y
D
E
L
P
H
---
Q
T
G
--
K
---
L
I
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
D
E
L
D
V
K
L
G
E
E
V
G
Y
S
I
R
F
E
N
K
T
S
S
K
T
-
L
L
K
Y
M
T
D
G
Q
L
L
R
E
A
M
H
D
-
R
D
M
S
R
Y
S
C
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
A
L
L
K
Q
L
S
E
R
R
K
D
L
K
I
I
V
M
S
A
T
L
D
A
Q
K
F
Q
S
Y
F
F
N
A
P
L
L
A
V
P
G
R
T
H
P
V
E
I
-
F
Y
T
P
E
A
E
R
------------------
D
Y
V
E
A
A
I
----------------------
R
T
V
L
Q
-----------
I
H
A
C
---------
E
-
P
E
-
G
D
I
L
L
F
L
T
G
E
E
E
I
E
D
A
C
R
R
I
S
L
E
V
D
E
M
I
----
R
E
----
S
D
--------
A
------
G
--
P
M
S
--------
V
Y
P
L
Y
G
T
L
P
P
H
Q
Q
Q
R
I
F
E
KAPQPFR
P
-------
G
G
R
P
-----
G
-------
R
-
K
C
I
V
A
T
N
I
A
E
T
S
L
T
I
D
G
I
V
Y
V
V
D
P
G
F
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K
Q
K
I
Y
N
P
R
T
R
V
E
S
L
L
V
S
P
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
E
A
F
K
-
K
-
E
L
I
-
E
Q
T
Y
P
E
I
L
R
S
N
L
S
N
T
V
L
E
L
K
K
L
G
V
E
D
L
V
H
F
D
--
L
M
D
P
P
A
P
E
T
M
M
R
A
L
E
E
L
N
Y
L
A
C
L
D
D
-
D
G
E
L
T
P
L
G
N
L
A
S
E
F
P
L
D
P
A
L
A
V
M
L
I
S
S
P
E
F
Y
C
S
N
E
I
L
S
I
T
S
L
L
S
V
P
Q
I
W
V
R
P
A
N
A
R
K
R
-
A
D
E
M
K
A
Q
F
A
H
P
D
G
D
H
L
T
L
L
N
A
Y
H
A
Y
--
K
G
A
E
A
R
G
E
D
M
K
K
-
W
C
H
E
H
F
L
S
Y
R
H
L
S
S
A
D
N
V
R
A
Q
L
K
K
I
M
E
T
H
G
I
-----
E
L
----
V
----
S
----
T
P
F
H
DKN
Y
Y
T
N
I
R
R
A
L
L
A
G
F
F
M
Q
V
A
M
R
E
S
S
N
-
S
K
V
Y
K
T
-
V
K
-
D
E
Q
L
V
L
I
H
P
S
T
T
V
T
T
P
Y
E
W
V
V
Y
N
E
F
V
L
T
T
K
Q
Y
V
R
T
V
T
N
I
R
P
E
W
L
L
E
I
A
P
V
-----
Y
Y
D
L
S
T
F
Q
K
G
E
I
K
N
A
L
T
R
V
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
65.53
36%
10
- C3 -
-
5I8Q
2
PRP43_YEAST
A:
[87-719]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
R
R
E
L
P
V
H
A
Q
R
D
E
F
L
K
L
Y
Q
N
N
Q
I
M
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
F
V
L
----
F
D
E
M
P
H
---
L
E
N
--
T
---
Q
V
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
E
E
M
D
V
K
L
G
E
E
V
G
Y
S
I
R
F
E
N
K
T
S
N
K
T
-
I
L
K
Y
M
T
D
G
M
L
L
R
E
A
M
E
D
-
H
D
L
S
R
Y
S
C
I
I
L
D
E
A
H
E
R
T
L
A
T
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I
L
M
G
L
L
K
Q
V
V
K
R
R
P
D
L
K
I
I
I
M
S
A
T
L
D
A
E
K
F
Q
R
Y
F
N
D
A
P
L
L
A
V
P
G
R
T
Y
P
V
E
L
-
Y
Y
T
P
------------------
E
F
Q
R
D
Y
L
D
S
A
I
----------------------
R
T
V
L
Q
---------------
I
H
A
T
E
E
A
G
-------
D
I
L
L
F
L
T
G
E
D
E
I
E
D
A
V
R
K
I
S
L
E
G
D
Q
L
V
----
R
E
----
E
G
--------
C
------
G
--
P
L
S
--------
V
Y
P
L
Y
G
S
L
P
P
H
Q
Q
Q
R
I
F
E
-------
P
-------
A
P
E
SHNG
R
P
G
-------
R
-
K
V
V
I
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T
N
I
A
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L
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I
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L
L
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A
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A
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R
A
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R
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C
F
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L
Y
T
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A
F
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-
K
-
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L
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Y
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L
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N
L
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L
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L
K
K
L
G
I
D
D
L
V
H
F
D
--
F
M
D
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P
A
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T
M
M
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A
L
E
E
L
N
Y
L
A
C
L
D
D
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N
-
L
T
P
L
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R
L
A
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F
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L
D
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M
L
A
V
M
L
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F
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L
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A
M
L
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P
N
V
F
I
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P
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K
D
K
K
R
-
A
D
D
A
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N
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F
A
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D
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L
L
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V
Y
H
A
F
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-
S
D
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A
--
Y
E
Y
G
I
H
K
W
C
R
D
H
Y
L
N
Y
R
S
L
S
A
A
D
N
I
R
S
Q
L
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L
M
N
R
Y
N
L
-----
E
L
----
N
T
T
D
Y
E
----
S
P
K
Y
----
F
D
N
I
R
K
A
L
A
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G
F
F
M
Q
V
A
-
K
K
R
S
G
-
A
K
G
Y
I
T
-
V
K
-
D
N
Q
D
V
L
I
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V
L
G
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D
A
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W
V
I
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N
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L
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S
K
N
Y
I
R
T
V
T
S
V
R
P
E
W
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
65.52
34%
36
- C3 -
-
3KX2
1
PRP43_YEAST
A:
[1-755]
-------------------------------------------------------------------------------------------------------------------------------------------
M
G
S
K
R
R
F
S
SEHPDPVETS
I
P
E
Q
A
A
E
I
A
E
E
L
S
--------------------------------
K
Q
H
P
L
P
S
E
E
P
L
V
H
H
D
AGEFKGLQRHHTS
A
E
E
A
Q
K
L
E
D
G
K
I
NPF
T
G
R
E
F
T
P
K
Y
----
V
D
I
L
K
I
R
R
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L
P
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H
A
Q
R
D
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F
L
K
L
Y
Q
N
N
Q
I
M
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
F
V
L
----
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--
D
E
M
---
P
H
L
EN
T
---
Q
V
A
C
T
Q
P
R
R
V
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V
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L
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-
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H
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L
-
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P
----------------------
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F
Q
R
D
Y
L
----------------------
D
S
A
I
R
T
----------
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L
Q
I
H
A
T
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E
A
G
--------
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L
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--------
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----
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----
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--------
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--
L
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-------
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------
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R
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K
V
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L
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R
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C
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A
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-
K
-
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L
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Q
S
Y
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L
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T
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L
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K
L
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L
V
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--
F
M
D
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M
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G
N
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Y
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---
S
D
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G
I
H
K
W
C
R
D
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Y
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A
D
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I
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L
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L
M
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Y
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L
-----
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L
N
T
T
D
Y
----
E
----
S
P
K
Y
----
F
D
N
I
R
K
A
L
A
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V
A
-
K
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-
W
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A
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Y
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K
L
S
L
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R
I
K
E
K
V
D
R
L
N
E
L
K
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
65.48
36%
24
- C3 -
-
5D0U
10
?
A:
[38-692]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
N
K
Q
R
Q
E
F
L
D
L
Y
H
N
N
Q
I
L
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
V
L
----
Y
D
E
L
P
H
---
Q
T
G
--
K
---
L
I
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
D
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L
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V
K
L
G
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V
G
Y
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F
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N
K
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K
T
-
L
L
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Y
M
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L
L
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A
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D
-
R
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T
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A
E
R
------------------
D
Y
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A
A
I
----------------------
R
T
V
L
Q
-----------
I
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A
C
---------
E
-
P
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G
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--------
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--
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--------
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P
-------
G
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-----
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-------
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L
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V
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L
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----
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----
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----
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-----
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Y
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F
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G
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I
K
N
A
L
T
R
V
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
65.29
38%
26
- C3 -
-
5D0U
10
?
A:
[32-676]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
R
R
K
L
P
V
N
K
Q
R
Q
E
F
L
D
L
Y
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I
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Y
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----
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--
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PH-
Q
T
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--
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---
L
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A
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------
D
---------------------------------------------
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----------
V
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A
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L
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C
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--------
D
A
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--------
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-------
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P
--
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-------
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A
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L
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I
L
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L
L
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I
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V
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P
A
N
A
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K
R
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A
D
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A
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D
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L
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L
L
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A
Y
H
A
Y
K
G
-
A
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A
--
R
G
E
D
M
K
K
W
C
H
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L
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Y
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L
S
S
A
D
N
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R
A
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L
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K
I
M
E
T
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-----
E
L
----
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----
S
T
PFH
D
K
N
Y
----
Y
T
N
I
R
R
A
L
L
A
G
F
F
M
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A
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M
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S
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S
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Y
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L
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L
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T
P
Y
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W
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V
Y
N
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F
V
L
T
T
K
Q
Y
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V
T
N
I
R
P
E
W
L
L
E
I
A
P
V
Y
Y
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
65.19
36%
13
- C3 -
-
2XAU
2
PRP43_YEAST
A:
[87-719]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
R
R
E
L
P
V
H
A
Q
R
D
E
F
L
K
L
Y
Q
N
N
Q
I
M
V
F
V
G
E
T
G
S
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K
T
T
Q
I
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Q
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----
F
D
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M
P
H
---
L
E
N
--
T
---
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L
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Y
Y
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------------------
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F
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R
D
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L
D
S
A
I
----------------------
R
T
V
L
Q
---------------
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H
A
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-------
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--------
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------
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--------
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R
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-------
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L
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L
----
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T
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DY
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----
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----
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V
R
P
E
W
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
64.37
38%
22
- C3 -
-
5LTJ
9
?
A:
[32-676]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
R
R
K
L
P
V
N
K
Q
R
Q
E
F
L
D
L
Y
H
N
N
Q
I
L
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
V
L
----
Y
--
D
E
L
PH-
Q
T
G
--
K
---
L
I
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
D
E
L
D
V
K
L
G
E
E
V
G
Y
S
I
R
F
E
N
K
T
S
S
K
T
-
L
L
K
Y
M
T
D
G
Q
L
L
R
E
A
M
H
D
-
R
D
M
S
R
Y
S
C
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
A
L
L
K
Q
L
S
E
R
R
K
D
L
K
I
I
V
M
S
A
T
L
D
A
Q
K
F
Q
S
Y
F
F
N
A
P
L
L
A
V
P
G
R
T
H
P
V
E
I
-
F
Y
T
P
E
A
E
R
------
D
---------------------------------------------
Y
----------
V
E
A
A
I
R
T
V
L
Q
I
H
-
A
C
E
P
E
G
D
I
L
L
F
L
T
G
E
E
E
I
E
--------
D
A
C
R
R
I
----
S
L
----
E
V
D
E
M
I
R
E
SD
A
------
G
--
P
M
S
--------
V
Y
P
L
Y
G
T
L
P
P
H
Q
Q
Q
R
I
F
E
-------
K
APQP---
F
R
P
GGR
P
--
G
-------
R
-
K
C
I
V
A
T
N
I
A
E
T
S
L
T
I
D
G
I
V
Y
V
V
D
P
G
F
S
K
Q
K
I
Y
N
P
R
T
R
V
E
S
L
L
V
S
P
I
S
K
A
S
A
Q
Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
E
A
F
K
K
E
-
L
-
I
-
E
Q
T
Y
P
E
I
L
R
S
N
L
S
N
T
V
L
E
L
K
K
L
G
V
E
D
L
V
H
F
D
--
L
M
D
P
P
A
P
E
T
M
M
R
A
L
E
E
L
N
Y
L
A
C
L
D
D
D
-
G
E
L
T
P
L
G
N
L
A
S
E
F
P
L
D
P
A
L
A
V
M
L
I
S
S
P
E
F
Y
C
S
N
E
I
L
S
I
T
S
L
L
S
V
P
Q
I
W
V
R
P
A
N
A
R
K
R
-
A
D
E
M
K
A
Q
F
A
H
P
D
G
D
H
L
T
L
L
N
A
Y
H
A
Y
K
G
-
A
E
A
--
R
G
E
D
M
K
K
W
C
H
E
H
F
L
S
Y
R
H
L
S
S
A
D
N
V
R
A
Q
L
K
K
I
M
E
T
H
G
I
-----
E
L
----
V
----
S
T
PFH
D
K
N
Y
----
Y
T
N
I
R
R
A
L
L
A
G
F
F
M
Q
V
A
-
M
R
E
S
S
N
S
K
V
Y
K
T
V
K
D
-
E
Q
L
V
L
I
H
P
S
T
T
V
T
-
T
P
Y
E
W
V
V
Y
N
E
F
V
L
T
T
K
Q
Y
V
R
T
V
T
N
I
R
P
E
W
L
L
E
I
A
P
V
Y
Y
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
64.30
36%
22
- C3 -
-
5LTK
1
?
A:
[38-692]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
N
K
Q
R
Q
E
F
L
D
L
Y
H
N
N
Q
I
L
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
V
L
----
Y
D
E
L
P
H
---
Q
T
G
--
K
---
L
I
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
D
E
L
D
V
K
L
G
E
E
V
G
Y
S
I
R
F
E
N
K
T
S
S
K
T
-
L
L
K
Y
M
T
D
G
Q
L
L
R
E
A
M
H
D
-
R
D
M
S
R
Y
S
C
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
A
L
L
K
Q
L
S
E
R
R
K
D
L
K
I
I
V
M
S
A
T
L
D
A
Q
K
F
Q
S
Y
F
F
N
A
P
L
L
A
V
P
G
R
T
H
P
V
E
I
-
F
Y
T
P
E
A
E
R
------------------
D
Y
V
E
A
A
I
----------------------
R
T
V
L
Q
-----------
I
H
A
C
---------
E
-
P
E
-
G
D
I
L
L
F
L
T
G
E
E
E
I
E
D
A
C
R
R
I
S
L
E
V
D
E
M
I
----
R
E
----
S
D
--------
A
------
G
--
P
M
S
--------
V
Y
P
L
Y
G
T
L
P
P
H
Q
Q
Q
R
I
F
E
KAPQPFR
P
-------
G
G
R
P
-----
G
-------
R
-
K
C
I
V
A
T
N
I
A
E
T
S
L
T
I
D
G
I
V
Y
V
V
D
P
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Q
K
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Y
N
P
R
T
R
V
E
S
L
L
V
S
P
I
S
K
A
S
A
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Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
E
A
F
K
-
K
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L
I
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E
Q
T
Y
P
E
I
L
R
S
N
L
S
N
T
V
L
E
L
K
K
L
G
V
E
D
L
V
H
F
D
--
L
M
D
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P
A
P
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M
M
R
A
L
E
E
L
N
Y
L
A
C
L
D
D
-
D
G
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L
T
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L
G
N
L
A
S
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F
P
L
D
P
A
L
A
V
M
L
I
S
S
P
E
F
Y
C
S
N
E
I
L
S
I
T
S
L
L
S
V
P
Q
I
W
V
R
P
A
N
A
R
K
R
-
A
D
E
M
K
A
Q
F
A
H
P
D
G
D
H
L
T
L
L
N
A
Y
H
A
Y
--
K
G
A
E
A
R
G
E
D
M
K
K
-
W
C
H
E
H
F
L
S
Y
R
H
L
S
S
A
D
N
V
R
A
Q
L
K
K
I
M
E
T
H
G
I
-----
E
L
----
V
----
S
----
T
P
F
H
DKN
Y
Y
T
N
I
R
R
A
L
L
A
G
F
F
M
Q
V
A
M
R
E
S
S
N
-
S
K
V
Y
K
T
-
V
K
-
D
E
Q
L
V
L
I
H
P
S
T
T
V
T
T
P
Y
E
W
V
V
Y
N
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F
V
L
T
T
K
Q
Y
V
R
T
V
T
N
I
R
P
E
W
L
L
E
I
A
P
V
-----
Y
Y
D
L
S
T
F
Q
K
G
E
I
K
N
A
L
T
R
V
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
64.30
36%
23
- C3 -
-
5LTJ
9
?
A:
[38-692]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
N
K
Q
R
Q
E
F
L
D
L
Y
H
N
N
Q
I
L
V
F
V
G
E
T
G
S
G
K
T
T
Q
I
P
Q
Y
V
L
----
Y
D
E
L
P
H
---
Q
T
G
--
K
---
L
I
A
C
T
Q
P
R
R
V
A
A
M
S
V
A
Q
R
V
A
D
E
L
D
V
K
L
G
E
E
V
G
Y
S
I
R
F
E
N
K
T
S
S
K
T
-
L
L
K
Y
M
T
D
G
Q
L
L
R
E
A
M
H
D
-
R
D
M
S
R
Y
S
C
I
I
L
D
E
A
H
E
R
T
L
A
T
D
I
L
M
A
L
L
K
Q
L
S
E
R
R
K
D
L
K
I
I
V
M
S
A
T
L
D
A
Q
K
F
Q
S
Y
F
F
N
A
P
L
L
A
V
P
G
R
T
H
P
V
E
I
-
F
Y
T
P
E
A
E
R
------------------
D
Y
V
E
A
A
I
----------------------
R
T
V
L
Q
-----------
I
H
A
C
---------
E
-
P
E
-
G
D
I
L
L
F
L
T
G
E
E
E
I
E
D
A
C
R
R
I
S
L
E
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D
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M
I
----
R
E
----
S
D
--------
A
------
G
--
P
M
S
--------
V
Y
P
L
Y
G
T
L
P
P
H
Q
Q
Q
R
I
F
E
KAPQPFR
P
-------
G
G
R
P
-----
G
-------
R
-
K
C
I
V
A
T
N
I
A
E
T
S
L
T
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D
G
I
V
Y
V
V
D
P
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K
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R
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R
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L
L
V
S
P
I
S
K
A
S
A
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Q
R
A
G
R
A
G
R
T
R
P
G
K
C
F
R
L
Y
T
E
E
A
F
K
-
K
-
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L
I
-
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Q
T
Y
P
E
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L
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N
L
S
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L
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L
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K
L
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V
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L
V
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F
D
--
L
M
D
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P
A
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M
M
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A
L
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L
N
Y
L
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D
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D
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L
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N
L
A
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P
L
D
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A
L
A
V
M
L
I
S
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P
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F
Y
C
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N
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I
L
S
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S
L
L
S
V
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Q
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W
V
R
P
A
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A
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K
R
-
A
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A
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A
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P
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L
L
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A
Y
H
A
Y
--
K
G
A
E
A
R
G
E
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M
K
K
-
W
C
H
E
H
F
L
S
Y
R
H
L
S
S
A
D
N
V
R
A
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L
K
K
I
M
E
T
H
G
I
-----
E
L
----
V
----
S
----
T
P
F
H
DKN
Y
Y
T
N
I
R
R
A
L
L
A
G
F
F
M
Q
V
A
M
R
E
S
S
N
-
S
K
V
Y
K
T
-
V
K
-
D
E
Q
L
V
L
I
H
P
S
T
T
V
T
T
P
Y
E
W
V
V
Y
N
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F
V
L
T
T
K
Q
Y
V
R
T
V
T
N
I
R
P
E
W
L
L
E
I
A
P
V
-----
Y
Y
D
L
S
T
F
Q
K
G
E
I
K
N
A
L
T
R
V
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------