@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLI8: (2017-11-02 )
MGIRITGTGLFHPTEIISNEELADSLNAYVEQYNQENAEKIAAGELEELRGSSAEFIEKASGIKRRYVIEKSGILDPTRLRPRLSERSNDELSIQAEWGVIAAKQAMENAGVTAEDIDVVILACSNMQRAYPAVAIEIQSALGIQGYAYDMNVACSAATFGLKQAADAIRSGARRVLLVNVEITSGHLDYRNRDCHFIFGDVATASIIEETTTKTGFEILDIHLFTQFSNNIRNNFGFLNRSEDAVVDDKLFRQDGRKVFKDVCPLVAKIINAQLEKMQLTANDIKRFWLHQANANMNELILKYVAGKDADLSRTPIILDEFANTSSAGVIIALHRTGHEVDDGEYGVISSFGAGYSVGSIVVQKHVA
Atome Classification :
(20 SA)
-------....---.....10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140..-.--.-.-.-.150.......160.......170-.-.-...-...180.......190........200.......210..-.-.---------....220.......--230--..-....-..240...--...--.250...-------....260.......270.......280.......290....-...300-------..--.....310.......320.......330...---..--..--340....------.....350.......360......--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------M
G
I
R
---
I
T
GTGLF
H
P
T
E
II
S
N
E
E
L
A
D
S
L
N
A
Y
V
E
Q
Y
N
Q
E
N
A
E
K
IAAG
E
L
E
E
L
RG
S
S
A
E
F
I
E
K
ASGI
K
R
R
Y
V
I
EKSGIL
D
P
T
R
LRPRLSERSND
E
L
S
I
Q
AEW
G
V
I
A
A
K
Q
A
M
E
NAGVTAED
I
D
V
V
I
L
ACSNMQRAY
P
A
V
A
I
E
I
QSALGI-Q--
G
-
Y
-
A
-
Y
DMNVA
C
S
A
A
T
F
G
L
K
Q
A
A
D
A
I
R
-S-G-A-
R
R
V
-
L
L
V
N
V
E
I
TSGHLDY-RNRD
C
H
F
I
FGDV
A
T
A
S
I
I
E
E
T-TT-K-T---------G
F
E
I
L
D
I
H
L
F
T
Q
F
S
--
N
N---I
R
-
N
NFG-FLNRSEDA--V
V
D
--
D
K
L
F
R
Q
D
-------
G
R
K
V
F
K
D
V
C
P
L
V
A
K
I
I
N
A
Q
L
E
K
M
QL
T
A
N
D
I
K
R
F
W
L
HQANA
N
-
M
N
E
L
I
L
-------
K
Y
--VAGKDADLSRT
P
I
I
L
D
EFANTSSA
G
V
I
I
A
L
H---RT--GH--E--VDDG------EY
G
V
I
SSFGAGY
S
V
G
S
I
V
V
Q
KHVA--
25
HHSearch
87.77
56%
-56
- C1 -
-
3LED
2
?
B:
[23-391]
-------
R
P
A
V
---
I
A
A
T
G
L
Y
T
P
P
D
S
V
S
N
A
E
L
V
E
A
F
N
T
Y
V
A
N
F
N
A
A
N
K
A
R
I
E
A
G
E
I
E
P
L
Q
P
S
S
S
E
F
I
E
K
A
S
G
I
K
S
R
Y
V
V
A
K
P
G
I
V
D
P
D
V
M
R
P
I
I
P
E
R
S
N
D
E
L
S
I
L
A
E
M
A
V
T
A
A
E
Q
A
I
E
R
W
G
K
P
R
E
R
I
G
A
V
L
C
A
C
S
N
M
Q
R
A
Y
P
A
M
A
I
E
V
Q
N
A
L
G
L
-
G
--
G
-
F
-
A
-
F
D
M
N
V
A
C
S
S
A
T
F
G
L
K
T
A
A
D
F
V
G
-
G
-
G
-
S
V
D
A
V
-
L
M
V
N
P
E
I
C
S
G
H
L
N
F
-
R
D
R
D
S
H
F
I
F
G
D
V
A
T
A
A
I
V
E
R
A
-
D
D
A
Q
-
G
---------
G
W
S
I
L
G
T
K
L
K
T
Q
F
S
--
N
N
---
I
R
-
N
N
A
G
-
F
L
N
R
A
W
P
E
GR
D
K
A
--
D
K
L
F
V
Q
Q
-------
G
R
K
V
F
K
E
V
V
P
L
V
S
E
M
I
I
E
H
A
R
E
I
G
I
D
P
H
G
L
K
R
M
W
L
H
Q
A
N
I
N
-
M
N
E
I
I
G
-------
R
K
--
V
L
G
R
D
P
T
R
D
E
N
V
I
I
L
D
D
Y
A
N
T
S
S
A
G
S
I
I
A
F
H
---
K
H
--
Q
D
--
D
--
M
A
Q
G
------
D
L
G
L
I
C
S
F
G
A
G
Y
S
A
G
T
V
F
V
Q
K
-----
1
PsiBlast_PDB
78.97
55%
3
- C1 -
-
3LED
-
?
A:
[20-391]
-------
Q
G
V
R
P
A
V
I
A
A
T
G
L
Y
T
P
P
D
S
V
S
N
A
E
L
V
E
A
F
N
T
Y
V
A
N
F
N
A
A
N
K
A
R
I
E
A
G
E
I
E
P
L
Q
P
S
S
S
E
F
I
E
K
A
S
G
I
K
S
R
Y
V
V
A
K
P
G
I
V
D
P
D
V
M
R
P
I
I
P
E
R
S
N
D
E
L
S
I
L
A
E
M
A
V
T
A
A
E
Q
A
I
E
R
W
G
K
P
R
E
R
I
G
A
V
L
C
A
C
S
N
M
Q
R
A
Y
P
A
M
A
I
E
V
Q
N
A
L
G
L
-
G
--
G
-
F
-
A
-
F
D
M
N
V
A
C
S
S
A
T
F
G
L
K
T
A
A
D
F
V
G
-
G
-
G
-
S
V
D
A
V
-
L
M
V
N
P
E
I
C
S
G
H
L
N
F
-
R
D
R
D
S
H
F
I
F
G
D
V
A
T
A
A
I
V
E
R
A
D
D
A
-
Q
-
G
---------
G
W
S
I
L
G
T
K
L
K
T
Q
F
S
--
N
N
---
I
R
-
N
N
A
G
-
F
L
N
R
A
W
P
E
--
G
R
D
KA
D
K
L
F
V
Q
Q
-------
G
R
K
V
F
K
E
V
V
P
L
V
S
E
M
I
I
E
H
A
R
E
I
G
I
D
P
H
G
L
K
R
M
W
L
H
Q
A
N
I
N
-
M
N
E
I
I
G
-------
R
K
--
V
L
G
R
D
P
T
R
D
E
N
V
I
I
L
D
D
Y
A
N
T
S
S
A
G
S
I
I
A
F
H
---
K
H
--
Q
D
--
D
--
M
A
Q
G
------
D
L
G
L
I
C
S
F
G
A
G
Y
S
A
G
T
V
F
V
Q
K
-----
40
HHSearch
67.14
28%
-58
- C1 -
-
2GYO
2
FABH_ECOLI
A:
[1-317]
-------
M
Y
T
K
---
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
------------------------
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
--------------------
E
T
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
-
K
G-
C
-
P
-
A
-
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
-
S
-
G
-
A
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
-
E
E
--------------
P
G
I
I
S
T
H
L
H
A
D
G
S
YG
E
L
---
L
T
-
L
P
N
A
D
R
V
N
P
-------
E
N
--
S
I
H
L
T
M
A
-------
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
-
I
I
S
A
T
A
-------
K
K
---
L
G
M
S
M
D
--
N
V
V
V
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
---
E
A
--
V
R
D
G
R
--
I
K
P
G
------
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
-----
39
HHSearch
67.10
28%
-61
* C1 *
-
1HNJ
1
FABH_ECOLI
A:
[1-317]
-------
M
Y
T
K
---
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
A
D
L
E
K
M
V
D
T
S
------------------------
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
N
--------------------
E
T
V
S
T
M
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
-
K
G-
C
-
P
-
A
-
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
-
S
-
G
-
A
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
-
E
E
--------------
P
G
I
I
S
T
H
L
H
A
D
G
S
YG
E
L
---
L
T
-
L
P
N
A
D
R
V
N
P
-------
E
N
--
S
I
H
L
T
M
A
-------
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
-
I
I
S
A
T
A
-------
K
K
---
L
G
M
S
M
D
--
N
V
V
V
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
---
E
A
--
V
R
D
G
R
--
I
K
P
G
------
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
F
-----
20
PsiBlast_PDB
64.38
25%
-62
- C1 -
-
4WZU
-
FABH2_VIBCH
A:
[8-319]
--------------
I
T
G
W
G
K
C
L
P
P
A
T
L
S
N
H
D
L
S
T
F
L
D
------------------------
T
S
D
E
W
I
Q
S
R
T
G
I
E
Q
R
----------------
R
I
S
H
V
N
T
S
D
L
A
------
T
V
A
A
Q
H
A
I
A
C
A
G
V
S
V
E
E
I
D
L
I
I
V
A
T
C
S
P
D
S
L
I
P
N
I
A
S
R
V
Q
Q
N
L
G
I
P
S
--
A
-
A
-
A
-
F
D
L
N
A
A
C
T
G
F
L
Y
G
L
E
T
A
T
R
L
M
Q
A
S
-
H
-
Y
-
R
H
A
-
L
V
I
G
A
E
R
L
S
F
Y
L
D
W
-
T
K
R
D
T
A
V
L
F
G
D
G
A
G
A
V
V
L
S
K
T
-
E
Q
-
K
-
V
---------
G
L
Q
D
A
Q
I
G
C
D
A
Q
G
R
--
D
I
---
L
A
V
P
K
F
G
-
T
A
M
D
R
F
D
A
--
D
N
G
--
Y
W
A
F
D
F
V
-------
G
K
E
I
F
K
R
A
V
R
G
M
G
A
A
A
Q
Q
V
L
A
R
S
G
L
S
T
E
E
I
D
V
V
I
P
H
Q
A
N
I
R
-
I
I
Q
T
L
C
-------
D
---
L
A
G
I
A
Q
D
--
K
A
F
V
N
I
H
R
Y
G
N
T
S
A
A
T
V
P
I
A
L
C
---
E
A
--
L
E
--
Q
GK
I
K
P
H
------
D
D
L
L
V
A
A
F
G
A
G
L
T
W
G
A
----------
2
PsiBlast_PDB
64.27
25%
-49
- C1 -
-
2EBD
-
FABH_AQUAE
A:
[1-308]
-------
M
G
T
K
---
I
I
G
T
G
V
Y
L
P
K
N
V
L
T
N
------------------------
F
D
L
E
K
I
V
D
T
S
D
E
W
I
T
T
R
T
G
I
K
E
R
R
I
A
K
---------------
E
E
T
I
T
Y
M
A
T
Q
A
------
A
K
E
A
L
R
E
A
N
L
S
P
E
E
L
D
L
I
I
L
A
T
L
T
P
Q
K
R
F
P
S
T
A
C
L
V
Q
A
Q
L
K
A
-
K
--
G
V
Y
-
A
-
F
D
I
S
A
A
C
S
G
F
I
Y
A
L
D
I
A
D
S
F
I
K
-
S
-
G
K
A
-
K
N
V
-
L
V
I
G
A
E
K
L
S
E
A
V
D
W
-
E
D
R
S
T
C
V
L
F
G
D
G
A
G
A
V
V
V
T
R
S
-
E
D
-
K
-
S
-----------
D
I
L
A
T
R
M
Y
A
E
G
S
--
L
E
EL
L
H
A
-
D
N
C
G
-
Y
I
-----------------
R
M
K
-------
G
R
E
L
F
K
V
A
V
R
S
M
E
E
V
C
R
E
V
L
E
K
A
G
V
K
P
E
E
V
S
L
V
I
P
H
Q
A
N
V
R
I
I
N
A
L
A
E
-------
K
L
--
N
I
P
K
E
----
K
V
F
V
N
I
Q
K
Y
G
N
T
S
A
A
S
I
P
I
A
L
H
---
E
A
--
I
K
--
E
GK
V
K
R
G
------
D
L
I
L
M
T
A
M
G
G
G
L
T
W
G
A
V
L
L
R
------
18
PsiBlast_PDB
63.41
25%
-54
- C1 -
-
5BNM
1
FABH_ECOLI
A:
[1-316]
-------
M
Y
T
K
---
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
------------------------
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
-----------------
N
E
T
V
S
T
M
---
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
-
K
--
G
-
C
P
A
-
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
-
S
-
G
-
A
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
-
E
E
-
P
-------------
G
I
I
S
T
H
L
H
A
D
G
S
------------
Y
G
-
E
L
L
T
L
P
N
A
-------
D
R
V
N
P
E
N
SIHLTMA
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
-
I
I
S
A
T
A
-------
K
K
--
L
G
---
M
S
M
D
N
V
V
V
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
--
G
---
R
--
I
K
P
G
------
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
------
15
PsiBlast_PDB
62.37
25%
-53
- C1 -
-
2EFT
2
FABH_ECOLI
A:
[1-316]
-------
M
Y
T
K
---
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
------------------------
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
-----------------
N
E
T
V
S
T
M
---
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
-
K
--
G
-
C
P
A
-
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
-
S
-
G
-
A
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
-
E
E
-
P
-------------
G
I
I
S
T
H
L
H
A
D
G
S
------------
Y
G
-
E
L
L
T
L
P
N
A
-------
D
R
V
N
P
E
N
SIHLTMA
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
-
I
I
S
A
T
A
-------
K
K
--
L
G
---
M
S
M
D
N
V
V
V
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
--
G
---
R
--
I
K
P
G
------
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
------
19
PsiBlast_PDB
62.27
25%
-54
- C1 -
-
5BNS
1
FABH_ECOLI
A:
[1-316]
-------
M
Y
T
K
---
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
------------------------
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
-----------------
N
E
T
V
S
T
M
---
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
-
K
--
G
-
C
P
A
-
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
-
S
-
G
-
A
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
-
E
E
-
P
-------------
G
I
I
S
T
H
L
H
A
D
G
S
------------
Y
G
-
E
L
L
T
L
P
N
A
-------
D
R
V
N
P
E
N
SI
H
L
T
M
A
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
-
I
I
S
A
T
A
-------
K
K
--
L
G
---
M
S
M
D
N
V
V
V
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
--
G
---
R
--
I
K
P
G
------
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
------
16
PsiBlast_PDB
62.16
25%
-53
- C1 -
-
2GYO
2
FABH_ECOLI
A:
[1-316]
-------
M
Y
T
K
---
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
------------------------
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
-----------------
N
E
T
V
S
T
M
---
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
-
K
--
G
-
C
P
A
-
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
-
S
-
G
-
A
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
-
E
E
-
P
-------------
G
I
I
S
T
H
L
H
A
D
G
S
------------
Y
G
-
E
L
L
T
L
P
N
A
-------
D
R
V
N
P
E
N
SIHLTMA
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
-
I
I
S
A
T
A
-------
K
K
--
L
G
---
M
S
M
D
N
V
V
V
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
--
G
---
R
--
I
K
P
G
------
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
------
17
PsiBlast_PDB
62.04
25%
-53
- C1 -
-
4Z8D
1
FABH_ECOLI
A:
[1-316]
-------
M
Y
T
K
---
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
------------------------
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
-----------------
N
E
T
V
S
T
M
---
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
-
K
--
G
-
C
P
A
-
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
-
S
-
G
-
A
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
-
E
E
-
P
-------------
G
I
I
S
T
H
L
H
A
D
G
S
------------
Y
G
-
E
L
L
T
L
P
N
A
-------
D
R
V
N
P
E
N
SIHLTMA
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
-
I
I
S
A
T
A
-------
K
K
--
L
G
---
M
S
M
D
N
V
V
V
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
--
G
---
R
--
I
K
P
G
------
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
------
11
PsiBlast_PDB
62.04
25%
-51
- C1 -
-
1HN9
-
FABH_ECOLI
A:
[1-316]
-------
M
Y
T
K
---
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
------------------------
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
-----------------
N
E
T
V
S
T
M
---
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
-
K
--
G
-
C
P
A
-
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
-
S
-
G
-
A
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
-
E
E
-
P
-------------
G
I
I
S
T
H
L
H
A
D
G
S
------------
Y
G
-
E
L
L
T
L
P
N
A
-------
D
R
V
N
P
E
N
SIHLTMA
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
-
I
I
S
A
T
A
-------
K
K
--
L
G
---
M
S
M
D
N
V
V
V
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
--
G
---
R
--
I
K
P
G
------
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
------
13
PsiBlast_PDB
61.96
25%
-54
- C1 -
-
1HNJ
1
FABH_ECOLI
A:
[1-316]
-------
M
Y
T
K
---
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
------------------------
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
-----------------
N
E
T
V
S
T
M
---
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
-
K
--
G
-
C
P
A
-
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
-
S
-
G
-
A
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
-
E
E
-
P
-------------
G
I
I
S
T
H
L
H
A
D
G
S
------------
Y
G
-
E
L
L
T
L
P
N
A
-------
D
R
V
N
P
E
N
SIHLTMA
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
-
I
I
S
A
T
A
-------
K
K
--
L
G
---
M
S
M
D
N
V
V
V
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
--
G
---
R
--
I
K
P
G
------
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
------
7
PsiBlast_PDB
61.74
25%
-51
- C1 -
-
4YLT
-
FABH_YERPE
A:
[1-315]
-------
M
Y
T
K
---
I
L
G
T
G
S
Y
L
P
V
Q
V
R
S
N
------------------------
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
R
I
A
G
----
L
D
E
T
----------------
V
A
T
M
G
F
Q
A
A
E
K
A
L
E
M
A
G
I
D
K
D
D
I
G
L
I
I
V
A
T
T
S
S
S
H
A
F
P
S
S
A
C
Q
V
Q
R
M
L
G
I
-
K
--
D
-
A
-
A
S
F
D
L
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
-
S
-
G
-
A
V
K
H
A
-
I
V
I
G
S
D
V
L
S
R
A
L
D
P
-
E
D
R
G
T
I
I
L
F
G
D
G
A
G
A
V
V
L
G
A
S
-
E
Q
-
P
-
G
------------
I
M
S
T
H
L
H
A
D
G
R
--
Y
G
---
E
L
-
L
A
L
P
-
Y
P
-------------
P
A
Y
V
T
M
A
-------
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
Q
V
N
N
L
D
R
T
A
L
D
W
L
V
P
H
Q
A
N
L
R
-
I
I
S
A
T
A
-------
K
K
--
L
G
---
M
G
M
D
K
V
V
I
T
L
D
R
H
G
N
T
S
A
A
S
V
P
S
A
F
D
E
A
V
R
D
--
G
---
R
--
I
Q
R
G
------
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
------
12
PsiBlast_PDB
61.67
25%
-51
- C1 -
-
1HND
1
FABH_ECOLI
A:
[1-316]
-------
M
Y
T
K
---
I
I
G
T
G
S
Y
L
P
E
Q
V
R
T
N
------------------------
A
D
L
E
K
M
V
D
T
S
D
E
W
I
V
T
R
T
G
I
R
E
R
H
I
A
A
P
-----------------
N
E
T
V
S
T
M
---
G
F
E
A
A
T
R
A
I
E
M
A
G
I
E
K
D
Q
I
G
L
I
V
V
A
T
T
S
A
T
H
A
F
P
S
A
A
C
Q
I
Q
S
M
L
G
I
-
K
--
G
-
C
P
A
-
F
D
V
A
A
A
C
A
G
F
T
Y
A
L
S
V
A
D
Q
Y
V
K
-
S
-
G
-
A
V
K
Y
A
-
L
V
V
G
S
D
V
L
A
R
T
C
D
P
-
T
D
R
G
T
I
I
I
F
G
D
G
A
G
A
A
V
L
A
A
S
-
E
E
-
P
-------------
G
I
I
S
T
H
L
H
A
D
G
S
------------
Y
G
-
E
L
L
T
L
P
N
A
-------
D
R
V
N
P
E
N
SIHLTMA
G
N
E
V
F
K
V
A
V
T
E
L
A
H
I
V
D
E
T
L
A
A
N
N
L
D
R
S
Q
L
D
W
L
V
P
H
Q
A
N
L
R
-
I
I
S
A
T
A
-------
K
K
--
L
G
---
M
S
M
D
N
V
V
V
T
L
D
R
H
G
N
T
S
A
A
S
V
P
C
A
L
D
E
A
V
R
D
--
G
---
R
--
I
K
P
G
------
Q
L
V
L
L
E
A
F
G
G
G
F
T
W
G
S
A
L
V
R
------
6
PsiBlast_PDB
61.24
26%
-41
- C1 -
-
4DFE
-
?
A:
[13-332]
----------
R
---
V
L
G
T
G
S
Y
L
P
P
N
R
V
T
N
Q
D
L
A
---------------
K
R
L
A
---
I
E
----
T
S
D
E
W
I
V
A
R
T
G
I
H
A
R
Y
F
A
E
-----------
P
D
V
T
T
---------
S
D
L
A
F
I
A
S
Q
R
A
I
E
A
A
D
I
D
P
Q
S
I
D
L
I
I
V
A
T
S
T
P
D
F
V
F
P
S
T
A
C
L
L
Q
N
K
L
G
I
-
R
NH
G
-
A
-
A
-
F
D
V
Q
A
V
C
S
G
F
A
Y
A
V
A
T
A
D
S
F
I
R
-
S
-
G
-
Q
-
H
R
T
A
L
V
I
G
A
E
T
F
S
R
I
L
D
F
-
K
D
R
T
T
C
V
L
F
G
D
G
A
G
A
-
V
I
L
Q
A
-
S
D
-
E
-
P
---------
G
V
L
A
S
A
L
H
A
D
G
S
H
S
---
N
---
I
L
-
C
T
P
G
-
N
V
N
G
G
--
V
--
V
S
G
--
S
A
F
L
H
M
D
-------
G
Q
A
V
F
K
L
A
V
N
V
L
E
K
V
A
V
E
A
L
E
K
A
N
L
S
A
E
Q
I
D
W
L
I
P
H
Q
A
N
I
R
-
I
M
Q
S
T
C
-------
R
K
--
L
G
L
P
Q
---
E
R
M
I
V
T
V
G
E
H
G
N
T
S
A
A
S
I
P
L
A
L
D
V
A
V
R
D
--
G
---
R
--
I
K
R
G
------
Q
N
V
L
I
E
G
V
G
G
G
F
T
W
G
A
S
V
I
R
------
5
PsiBlast_PDB
61.13
25%
-65
- C1 -
-
1MZJ
2
FABH_STRLI
A:
[13-323]
----------
R
---
V
L
G
V
G
S
Y
R
P
R
R
E
V
S
N
K
E
V
C
T
W
I
D
------------------------
S
T
E
E
W
I
E
T
R
T
G
I
R
S
R
R
I
A
E
P
------------------
D
E
-
T
I
Q
V
-
M
G
V
A
A
S
R
R
A
L
E
H
A
G
V
D
P
A
E
I
D
L
V
V
V
S
T
M
T
N
F
V
H
T
P
P
L
S
V
A
I
A
H
E
L
G
A
D
N
--
A
-
G
-
G
-
F
D
L
S
A
A
C
A
G
F
C
H
A
L
S
I
A
A
D
A
V
E
-
S
G
G
-
S
-
R
H
V
-
L
V
V
A
T
E
R
M
T
D
V
I
D
L
-
A
D
R
S
L
S
F
L
F
G
D
G
A
G
A
A
V
V
G
P
S
-
D
V
-
P
-
G
I
G
P
V
V
R
G
I
D
G
T
G
L
G
S
L
H
M
S
S
S
W
D
--
Q
Y
---
V
------------
E
D
P
--
S
V
G
--
R
P
A
L
V
M
D
-------
G
K
R
V
F
R
W
A
V
A
D
V
V
P
A
A
R
E
A
L
E
V
A
G
L
T
V
G
D
L
V
A
F
V
P
H
Q
A
N
L
R
-
I
I
D
V
L
V
D
R
L
GVPE
H
V
--
V
V
S
R
D
A
---------
E
D
T
G
N
T
S
S
A
S
V
A
L
A
L
D
---
R
L
V
R
S
G
--
A
--
V
P
G
G
------
G
P
A
L
M
I
G
F
G
A
G
L
S
-------------
44
HHSearch
59.91
25%
-62
- C1 -
-
2QO1
3
FABH_MYCTU
B:
[11-334]
-------
R
S
V
G
---
L
L
S
V
G
A
Y
R
P
E
R
V
V
T
N
D
E
I
C
Q
H
I
D
S
S
------------------------
D
E
W
I
Y
T
R
T
G
I
K
T
R
R
F
A
A
D
D
--------------------
E
S
A
A
S
M
A
T
E
A
C
R
R
A
L
S
N
A
G
L
S
A
A
D
I
D
G
V
I
V
T
T
N
T
H
F
L
Q
T
P
P
A
A
P
M
V
A
A
S
L
G
A
-
K
G-
I
-
L
-
G
-
F
D
L
S
A
G
C
A
G
F
G
Y
A
L
G
A
A
A
D
M
I
R
-
G
-
G
-
G
A
A
T
M
-
L
V
V
G
T
E
K
L
S
P
T
I
D
M
-
Y
D
R
G
N
C
F
I
F
A
D
G
A
A
A
V
V
V
G
E
T
-
P
F
--------------
Q
G
I
G
P
T
V
A
G
S
D
G
E
QA
D
A
---
I
R
-
Q
D
I
D
-
W
I
T
F
A
Q
N
P
--
S
G
P
--
R
P
F
V
R
L
E
-------
G
P
A
V
F
R
W
A
A
F
K
M
G
D
V
G
R
R
A
M
D
A
A
G
V
R
P
D
Q
I
D
V
F
V
P
H
Q
A
N
S
R
-
I
N
E
L
L
V
-------
K
N
---
L
Q
L
R
P
D
A
-
V
V
A
N
D
I
E
H
T
G
N
T
S
A
A
S
I
P
L
A
M
A
---
E
L
--
L
T
TG
A
--
A
K
P
G
------
D
L
A
L
L
I
G
Y
G
A
G
L
S
Y
A
A
Q
V
V
R
M
P
K
---
47
Fugue
59.66
27%
-20
- C1 -
-
1MZJ
2
FABH_STRLI
A:
[3-336]
G
L
R
V
P
E
R
R
F
S
R
---
V
L
G
V
G
S
Y
R
P
R
R
E
V
S
N
K
E
V
C
T
W
I
---------------
D
---------
S
T
E
E
W
I
E
T
R
T
G
I
R
S
R
R
I
A
E
P
--------------------
D
E
T
I
Q
V
M
G
V
A
A
S
R
R
A
L
E
H
A
G
V
D
P
A
E
I
D
L
V
V
V
S
T
M
T
N
F
V
H
T
P
P
L
S
V
A
I
A
H
E
L
G
A
-
D
N-
A
-
G
-
G
-
F
D
L
S
A
A
C
A
G
F
C
H
A
L
S
I
A
A
D
A
V
E
-
S
-
G
G
S
-
R
H
V
-
L
V
V
A
T
E
R
M
T
D
V
I
D
L
A-
D
R
S
L
S
F
L
F
G
D
G
A
G
A
A
V
V
G
P
S
--
D
--V
P
---------
G
I
G
P
V
V
R
G
I
D
G
T
G
L
--
G
S
---
L
H
-
M
S
S
S
-
W
D
Q
Y
V
E
D
P
--
S
V
G
--
R
P
A
L
V
M
D
-------
G
K
R
V
F
R
W
A
V
A
D
V
V
P
A
A
R
E
A
L
E
V
A
G
L
T
V
G
D
L
V
A
F
V
P
H
Q
A
N
L
R
-
I
I
D
V
L
V
-------
D
R
L
G
V
P
E
H
V
V
V
S
----
R
D
A
E
D
T
G
N
T
S
S
A
S
V
A
L
A
L
D
---
R
L
--
V
R
--
S
------GAVPGG
G
P
A
L
M
I
G
F
G
A
G
L
S
Y
A
G
Q
A
L
L
L
P
D
P
PS
31
HHSearch
59.62
28%
-31
- C1 -
-
3IL3
-
FABH_HAEIN
A:
[1-316]
-------
M
N
S
R
---
I
L
S
T
G
S
Y
L
P
S
H
I
R
T
N
A
D
L
E
K
M
V
D
T
S
------------------------
D
E
W
I
V
T
R
S
G
I
R
E
R
R
I
A
A
E
D
--------------------
E
T
V
A
T
M
G
F
E
A
A
K
N
A
I
E
A
A
Q
I
N
P
Q
D
I
E
L
I
I
V
A
T
T
S
H
S
H
A
Y
P
S
A
A
C
Q
V
Q
G
L
L
N
I
-
D
D-
A
-
I
-
S
-
F
D
L
A
A
A
-
T
G
F
V
Y
A
L
S
V
A
D
Q
F
I
R
-
A
-
G
-
K
V
K
K
A
-
L
V
I
G
S
D
L
N
S
R
K
L
D
E
-
T
D
R
S
T
V
V
L
F
G
D
G
A
G
A
V
I
L
E
A
S
-
E
Q
--------------
E
G
I
I
S
T
H
L
H
A
S
A
D
--
K
N
------
N
A
L
V
-
L
A
Q
P
-
E
R
G
--
I
E
K
--
S
G
Y
I
E
M
Q
-------
G
N
E
T
F
K
L
A
V
R
E
L
S
N
V
V
E
E
T
L
L
A
N
N
L
D
K
K
D
L
D
W
L
V
P
H
Q
A
N
L
R
-
I
I
T
A
T
A
-------
K
K
---
L
E
M
D
M
S
--
Q
V
V
V
T
L
D
K
Y
A
N
N
S
A
A
T
V
P
V
A
L
D
---
E
A
--
I
R
D
G
R
--
I
Q
R
G
------
Q
L
L
L
L
E
A
F
G
G
G
W
T
W
G
S
A
L
V
R
F
-----