@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLJ4: (2017-11-03 )
MQRCLMDSKTTKLPAYSETLSIEGMTCASCVGRVEKALKKVENVEIANVNLATEKAVVYSNQPIQREALVKAVERAGYDVPKAAPVELSIEGMTCASCVARVEKALKKVEGVQNTTVNLATEQAWVQADPSVNVEDLIRAVKKAGYDAKASEKNQDEQLDKKASELDQLKKDLIISIVLALPVFILEMCSHLIPAFHMWVMHTIGQYNSWLLQFVLTTLVLVFPGRRFYQKGIPALWRLAPDMNSLVAVGTLAAYSFSVVATFMPQVLPEGTVNVYFEAAAVIVSLILLGRYFEAKAKGRTSQAIQHLVGMQPKTARIQRNGQIVEVAVAEVVSGTIVEIRPGERVPVDGEVVEGHSYIDESMITGEPVPVEKIIGQQVVGGTVNQNGTLNIRATAVGSSSVLSQIIRMVEQAQGSKLPIQGLVDKVTMWFVPAVMLIAAITFLVWFIWGPEPALTFGLVNAVAVLIIACPCAMGLATPTSIMVGTGRGAELGVLFRKGEALQLLQEAQVVAVDKTGTLTEGKPTLTDFNVQSGFERNQVLTLVASVEAKSEHPIALAIVQAAESEGLNLLPVTAFNSITGSGIEAEVSGQKVQIGADRYMHELRLDTSSFQAIAAQLGEEGKTPLYVAIDQQLAAIIAVADPIKETTYAAIEALHQLGLKVAMITGDNRHTAQAIAKKLNIDEVVAEVLPEGKVDTVRQLQKQYGRLAFVGDGINDAPALAQADVGLAIGTGTDVAIEAADVVLMSGSLKGVPNAIALSKATMRNIRQNLFWAFVYNVALIPIAAGALYPAFGVLLSPMFAAGAMALSSVFVLGNALRLKRFHAPVH
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90--........100.......110.......120.......130........140.......150......--.160.......170.-......180.......190.......200.......210.......220.......230.......240........250.......260.......------270.......280.......290.......300.......310....-...320.......330.......340.......350....-...360.......370....----------...380.......390.......400.......410.......420.......430.......440...--------....450.......460.......470.......480.......490.......500.......510.......520.......530....-------------------...540......----------------.550.......560.......570-------.........580.......------590.........600......--------------.610...-....620.......630-----------------------........640.......650.......660.......670.......680.-----------------------------------------------------......690.......700.......710.......720.......730........740.....---..750-.......760.......770...-....780.......790.......800.......810.......820......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQRCLMDSKTTKLPAYS
E
T
L
SIEG
M
T
C
A
S
C
V
G
R
V
E
K
A
L
K
K
VEN
V
E
I
A
N
V
N
LA
T
E
K
A
V
V
YSNQP
I
Q
R
E
A
L
V
K
A
V
E
RAGYDVPKAA
P
V
E
L
S
IE--G
M
T
C
A
S
C
V
A
R
V
E
K
A
L
K
K
V
EGVQNT
T
V
N
L
ATE
Q
A
W
VQADPS-V
N
V
E
D
L
I
R
A
V
K
KAGYDAKASEKN
Q
D
E
Q
--
L
D
K
K
A
S
E
L
D
Q
L
K
K
D
L
-
I
I
S
I
V
L
A
L
P
V
F
I
L
E
M
C
S
H
L
I
P
A
F
H
M
W
V
M
H
T
I
G
Q
Y
N
S
W
L
L
Q
F
V
L
T
T
L
V
L
VFP
G
R
R
F
Y
Q
KG
I
P
A
L
W
R
LA-P
D
M
N
S
L
V
A
V
G
T
L
A
A
Y
S
F
S
V
V
A
T
F
M
P
Q
VLP------EG
T
V
N
V
Y
F
E
A
A
A
V
I
V
S
L
I
L
L
G
R
Y
F
E
AKAKGR
T
S
Q
A
I
Q
H
L
VGMQPKT
A
-
R
I
QRN
G
Q
I
V
E
V
A
V
A
E
VVS
G
T
I
V
E
IRPGERVPVD
G
E
VVEGH-S
Y
I
D
ESMITGEPV
P
V
E
K
I
IG----------QQVVGGTVNQN
G
T
L
N
I
R
A
T
AVG
S
S
S
V
L
S
Q
I
I
R
M
V
E
Q
AQGSKL
P
I
Q
G
L
V
D
K
V
T
M
W
F
V
P
A
V
M
L
I
A
A
I
T
F
L
V
--------
W
F
IWGP
E
P
A
L
T
F
G
L
V
N
A
V
A
V
L
I
IACPCAMGLATP
T
S
I
M
V
GTGRG
A
E
L
G
V
L
FRK
G
E
A
L
Q
L
L
Q
EA
Q
V
V
A
VDKTGTLTEGKPT
L
T
DFNVQSGFE-------------------RN
Q
V
L
T
L
V
A
SVE----------------AKSEH
P
I
A
L
A
I
V
QAAESEG
L
N
L
---------
L
P
VTAFNSITGSG
I
E
A
EVS------G--
Q
K
V
Q
IG
A
D
R
Y
M
H
E
LRLD
T
--------------
S
S
F
Q
A
I
A
-
A
Q
LGEEGKT
P
L
Y
V
A
I
D
------------------------
Q
Q
L
A
A
I
I
A
VAD
P
I
K
E
T
T
Y
A
A
I
E
A
L
H
QLG
L
K
V
A
M
I
TGDNR
H
T
A
Q
A
I
A
K
KL
N
I
D
-----------------------------------------------------
E
V
V
A
E
VLPEGK
V
D
T
V
R
Q
L
Q
K
QYG
R
L
A
F
VGDGINDA
P
A
L
A
QAD
V
G
L
A
IG-TGT
D
V
A
I
E
A
A
D
V
V
L
MS---GSLKG-VP
N
A
I
A
L
S
K
A
T
M
R
N
I
R
Q
N
L
F
W
A
F
-
V
Y
N
V
A
L
I
PIA
A
G
A
L
Y
P
A
F
G
V
L
L
S
P
M
F
A
A
G
A
M
A
L
S
S
V
F
V
LG
N
A
L
R
L
K
R
FHAPVH
51
Fugue
75.98
48%
-27
- C1 -
-
3RFU
-
COPA_LEGPH
A:
[74-736]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
Y
L
D
M
R
R
R
F
-
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
-------
H
F
I
S
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
-
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
W
P
G
V
F
P
HAFRSQ
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
--------
W
A
L
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
V
T
D
-
D
F
V
-------------------
E
D
N
A
L
A
L
A
A
A
L
E
----------------
H
Q
S
E
H
P
L
A
N
A
I
V
H
A
A
K
E
K
G
L
S
L
---------
G
S
V
E
A
F
E
A
P
T
G
K
G
V
V
G
Q
V
D
------
G
--
H
H
V
A
I
G
N
A
R
L
M
Q
E
H
G
G
D
N
--------------
A
P
L
F
E
K
A
-
D
E
L
R
G
K
G
A
S
V
M
F
M
A
V
D
------------------------
G
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
---
G
D
L
R
G
-
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
-
I
Y
N
V
L
G
V
P
L
A
A
G
V
L
Y
P
L
T
G
L
L
L
S
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
---
1
PsiBlast_PDB
74.75
47%
-26
- C1 -
-
3RFU
-
COPA_LEGPH
A:
[77-733]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
L
D
M
R
R
R
F
-
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
------
I
S
G
N
G
S
S
W
I
-
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
-
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
W
P
G
V
F
P
HAFRSQ
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
--------
W
A
L
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-
V
T
D
D
F
V
-------------------
E
D
N
A
L
A
L
A
A
A
L
E
----------------
H
Q
S
E
H
P
L
A
N
A
I
V
H
A
A
K
E
K
G
L
S
L
---------
G
S
V
E
A
F
E
A
P
T
G
K
G
V
V
G
Q
V
D
------
G
--
H
H
V
A
I
G
N
A
R
L
M
Q
E
H
G
G
D
N
--------------
A
P
L
F
E
K
A
-
D
E
L
R
G
K
G
A
S
V
M
F
M
A
V
D
------------------------
G
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
---
G
D
L
R
G
-
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
-
I
Y
N
V
L
G
V
P
L
A
A
G
V
L
Y
P
L
T
G
L
L
L
S
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
------
2
PsiBlast_PDB
74.21
47%
-24
- C1 -
-
4BEV
1
COPA_LEGPH
A:
[77-733]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
L
D
M
R
R
R
F
-
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
------
I
S
G
N
G
S
S
W
I
-
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
-
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
W
P
G
V
F
P
HAFRSQ
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
--------
W
A
L
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-
V
T
D
D
F
V
-------------------
E
D
N
A
L
A
L
A
A
A
L
E
----------------
H
Q
S
E
H
P
L
A
N
A
I
V
H
A
A
K
E
K
G
L
S
L
---------
G
S
V
E
A
F
E
A
P
T
G
K
G
V
V
G
Q
V
D
------
G
--
H
H
V
A
I
G
N
A
R
L
M
Q
E
H
G
G
D
N
--------------
A
P
L
F
E
K
A
-
D
E
L
R
G
K
G
A
S
V
M
F
M
A
V
D
------------------------
G
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
---
G
D
L
R
G
-
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
-
I
Y
N
V
L
G
V
P
L
A
A
G
V
L
Y
P
L
T
G
L
L
L
S
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
------
3
PsiBlast_PDB
74.03
47%
-25
- C1 -
-
4BYG
1
COPA_LEGPH
A:
[77-733]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
L
D
M
R
R
R
F
-
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
------
I
S
G
N
G
S
S
W
I
-
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
-
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
W
P
G
V
F
P
HAFRSQ
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
--------
W
A
L
L
G
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
I
-
V
T
D
D
F
V
-------------------
E
D
N
A
L
A
L
A
A
A
L
E
----------------
H
Q
S
E
H
P
L
A
N
A
I
V
H
A
A
K
E
K
G
L
S
L
---------
G
S
V
E
A
F
E
A
P
T
G
K
G
V
V
G
Q
V
D
------
G
--
H
H
V
A
I
G
N
A
R
L
M
Q
E
H
G
G
D
N
--------------
A
P
L
F
E
K
A
-
D
E
L
R
G
K
G
A
S
V
M
F
M
A
V
D
------------------------
G
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
---
G
D
L
R
G
-
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
-
I
Y
N
V
L
G
V
P
L
A
A
G
V
L
Y
P
L
T
G
L
L
L
S
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
------
4
PsiBlast_PDB
72.60
43%
-9
- C1 -
-
3J09
-
COPA_ARCFU
A:
[15-733]
------------------------------------------------------------------------------------
P
M
E
R
T
V
R
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
V
N
L
A
T
E
T
A
F
I
R
F
D
E
K
R
I
D
F
E
T
I
K
R
V
I
E
D
L
G
Y
G
V
------
V
D
E
Q
A
A
V
S
A
E
V
E
H
L
S
R
M
K
R
K
L
-
Y
V
A
---
A
F
A
G
V
L
L
L
F
L
A
H
F
I
S
L
----------
P
Y
E
D
F
V
-
Q
L
L
I
A
L
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
-
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
--
A
G
V
L
P
------
R
E
Y
S
--
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
-
V
V
I
R
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
--------
W
Y
F
I
A
H
A
P
-
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
N
G
D
E
-------------------
R
-
E
L
L
R
L
A
A
I
A
E
----------------
R
R
S
E
H
P
I
A
E
A
I
V
K
K
A
L
E
H
G
I
E
L
---------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
D
------------
G
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
V
--------------
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
A
V
I
V
A
R
N
------------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
E
-
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
---
D
D
L
R
D
-
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
-
I
Y
N
V
I
L
I
P
A
A
A
G
L
L
Y
P
I
F
G
V
V
F
R
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
P
I
R
52
Fugue
71.40
32%
-103
- C1 -
-
4UMW
-
ZNTA_SHISS
A:
[124-730]
--------------------------------
R
L
K
E
N
L
P
L
I
T
L
I
V
M
M
A
I
S
W
G
L
E
Q
F
----
N
H
P
F
G
Q
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
------
G
A
L
F
I
G
A
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
V
S
A
L
M
A
----
L
K
P
E
T
A
-
T
R
L
R
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
--------
P
P
L
L
-
F
A
A
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
H
P
A
T
G
I
S
-------------------
E
S
E
L
L
T
L
A
A
A
V
E
----------------
Q
G
A
T
H
P
L
A
Q
A
I
V
R
E
A
Q
V
A
E
L
A
I
---------
P
T
A
E
S
Q
R
A
L
V
G
S
G
I
E
A
Q
V
N
------
G
--
E
R
V
L
I
C
A
A
G
-----
K
H
P
A
--------------
D
A
F
A
G
L
I
-
N
E
L
E
S
A
G
Q
T
V
V
L
V
V
R
N
------------------------
D
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------
E
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
-
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
---
N
H
L
R
G
-
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
-
G
L
K
G
I
F
L
V
T
T
L
L
G
M
-------
T
G
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
------
5
PsiBlast_PDB
70.62
45%
-75
- C1 -
-
3J08
-
COPA_ARCFU
A:
[113-733]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
L
A
H
F
I
S
L
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
-
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
--
A
G
V
L
P
------
R
E
Y
S
--
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
-
V
V
I
R
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
--------
W
Y
F
I
A
H
A
P
-
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
N
G
D
E
-------------------
R
-
E
L
L
R
L
A
A
I
A
E
----------------
R
R
S
E
H
P
I
A
E
A
I
V
K
K
A
L
E
H
G
I
E
L
---------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
D
------------
G
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
V
--------------
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
A
V
I
V
A
R
N
------------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
E
-
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
---
D
D
L
R
D
-
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
-
I
Y
N
V
I
L
I
P
A
A
A
G
L
L
Y
P
I
F
G
V
V
F
R
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
P
I
R
62
HHSearch
63.87
32%
-34
- C1 -
-
4UMW
-
ZNTA_SHISS
A:
[124-730]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
K
E
N
L
-
P
L
I
T
L
--
I
V
M
M
A
I
S
W
G
L
--
E
Q
-------------
F
N
H
P
F
G
Q
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
A
-----------------------
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
A
-
T
R
L
R
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
--------
P
P
L
L
F
A
-
A
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
H
P
A
T
G
I
S
-------------------
E
S
E
L
L
T
L
A
A
A
V
E
----------------
Q
G
A
T
H
P
L
A
Q
A
I
V
R
E
A
Q
V
A
E
L
A
I
---------
P
T
A
E
S
Q
R
A
L
V
G
S
G
I
E
A
Q
V
N
------
G
--
E
R
V
L
I
C
A
A
G
K
H
P
-----
A
--------------
D
A
F
A
G
L
I
-
N
E
L
E
S
A
G
Q
T
V
V
L
V
V
R
N
------------------------
D
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
E
------------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
-
H
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
---
N
H
L
R
G
-
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
-
G
L
K
G
I
F
L
V
T
T
L
L
G
-------
M
T
G
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
------
7
PsiBlast_PDB
63.85
32%
-23
- C1 -
-
4UMW
-
ZNTA_SHISS
A:
[124-730]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
K
E
N
L
P
L
I
T
L
I
V
M
M
A
I
------
S
W
G
L
E
Q
F
N
----
H
P
F
G
Q
-----
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
A
---
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
A
T
A
E
-----------------------
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
A
-
T
R
L
R
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
PPLLFAAS
W
Q
E
W
---------
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
H
P
A
T
G
I
S
-------------------
E
S
E
L
L
T
L
A
A
A
V
E
----------------
Q
G
A
T
H
P
L
A
Q
A
I
V
R
E
A
Q
V
A
E
L
A
I
---------
P
T
A
E
S
Q
R
A
L
V
G
S
G
I
E
A
Q
V
N
------
G
--
E
R
V
L
I
C
A
A
G
-----
K
H
P
A
--------------
D
A
F
A
G
L
I
-
N
E
L
E
S
A
G
Q
T
V
V
L
V
V
R
N
------------------------
D
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------
E
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
-
Q
H
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
---
N
H
L
R
G
-
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
----
L
L
G
M
T
G
L
W
L
A
V
L
A
D
T
G
A
----
T
V
L
V
T
A
N
A
L
R
L
L
R
------
6
PsiBlast_PDB
60.70
32%
-19
- C1 -
-
4UMV
-
ZNTA_SHISS
A:
[126-730]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
N
L
P
L
I
T
L
I
V
M
M
A
I
------
S
W
G
L
E
Q
F
N
----
H
P
F
G
Q
-----
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
A
---
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
A
T
A
E
-----------------------
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
A
R
Q
G
V
S
A
L
M
A
L
K
P
E
T
A
-
T
R
L
R
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
LFAAS
W
Q
E
W
---------
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
H
P
A
T
G
I
S
-------------------
E
S
E
L
L
T
L
A
A
A
V
E
----------------
Q
G
A
T
H
P
L
A
Q
A
I
V
R
E
A
Q
V
A
E
L
A
I
---------
P
T
A
E
S
Q
R
A
L
V
G
S
G
I
E
A
Q
V
N
------
G
--
E
R
V
L
I
C
A
A
G
-----
K
H
P
A
--------------
D
A
F
A
G
L
I
-
N
E
L
E
S
A
G
Q
T
V
V
L
V
V
R
N
------------------------
D
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------
E
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
-
Q
H
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
---
N
H
L
R
G
-
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
----
L
L
G
M
T
G
L
W
L
A
V
L
A
D
T
G
A
----
T
V
L
V
T
A
N
A
L
R
L
L
R
------
65
HHSearch
54.50
22%
-16
- C1 -
-
2ZXE
1
?
A:
[135-796]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
-
L
V
I
R
D
G
E
K
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
FSSENPLETR
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
--------
S
L
I
L
G
--
Y
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
H
E
A
DTTENQSGAAFDKTS
A
T
W
S
A
L
S
R
I
A
A
L
C
N
R
A
V
F
Q
A
GQDNVPILKR
S
V
A
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
C
G
S
V
Q
G
M
R
D
R
N
PK
I
V
E
I
P
F
N
S
T
N
K
-
Y
Q
L
S
I
H
E
NEKSSE
S
R
Y
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
I
LLNG
A
E
E
P
LK
E
D
M
K
E
A
F
Q
N
A
Y
-
L
E
L
G
G
L
G
E
R
V
L
G
F
C
H
F
ALPEDKYNEG
Y
P
F
D
ADEPNFPTTD
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
SEGNET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
L
H
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
---
D
N
F
A
S
-
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
-
T
S
N
I
P
E
I
T
P
F
L
------------------------------------------
73
HHSearch
54.08
40%
-113
- C1 -
-
3SKX
-
A:
[5-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
F
E
R
A
K
D
L
Q
A
V
I
F
D
K
T
G
T
L
T
E
G
R
F
G
V
T
D
I
V
G
F
-
N
H
S
-------------------
E
D
E
L
L
Q
I
A
A
S
L
E
----------------
A
R
S
E
H
P
I
A
A
A
I
V
E
E
A
E
K
R
G
F
G
L
---------
T
E
V
E
E
F
R
A
I
P
G
K
G
V
E
G
I
V
N
------
G
--
R
R
Y
M
V
V
S
P
G
Y
I
R
E
L
G
I
K
-----------------
T
D
E
S
V
-
E
K
L
K
Q
Q
G
K
T
V
V
F
I
L
K
N
------------------------
G
E
V
S
G
V
I
A
L
A
D
R
I
R
P
E
S
R
E
A
I
S
K
L
K
A
I
G
I
K
C
M
M
L
T
G
D
N
R
F
V
A
K
W
V
A
E
E
L
G
L
D
-----------------------------------------------------
D
Y
F
A
E
V
L
P
H
E
K
A
E
K
V
K
E
V
Q
Q
-
K
Y
V
T
A
M
V
G
D
G
V
N
D
A
P
A
L
A
Q
A
D
V
G
I
A
I
G
-
A
G
T
D
V
A
V
E
T
A
D
I
V
L
V
R
---
N
D
P
R
D
-
V
A
A
I
V
E
L
S
R
K
T
Y
S
----------------------------------------------------------------
11
PsiBlast_PDB
53.65
41%
-114
- C1 -
-
3SKX
-
A:
[5-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
F
E
R
A
K
D
L
Q
A
V
I
F
D
K
T
G
T
L
T
E
G
R
F
G
V
T
D
I
-
V
G
F
N
H
S
-------------------
E
D
E
L
L
Q
I
A
A
S
L
E
----------------
A
R
S
E
H
P
I
A
A
A
I
V
E
E
A
E
K
R
G
F
G
L
---------
T
E
V
E
E
F
R
A
I
P
G
K
G
V
E
G
I
V
N
------
G
--
R
R
Y
M
V
V
S
P
G
Y
I
R
E
L
G
I
K
T
--------------
D
E
S
---
V
-
E
K
L
K
Q
Q
G
K
T
V
V
F
I
L
K
N
------------------------
G
E
V
S
G
V
I
A
L
A
D
R
I
R
P
E
S
R
E
A
I
S
K
L
K
A
I
G
I
K
C
M
M
L
T
G
D
N
R
F
V
A
K
W
V
A
E
E
L
G
L
D
-----------------------------------------------------
D
Y
F
A
E
V
L
P
H
E
K
A
E
K
V
K
E
V
Q
Q
K
Y
-
V
T
A
M
V
G
D
G
V
N
D
A
P
A
L
A
Q
A
D
V
G
I
A
I
G
-
A
G
T
D
V
A
V
E
T
A
D
I
V
L
V
R
---
N
D
P
R
D
-
V
A
A
I
V
E
L
S
R
K
T
Y
S
----------------------------------------------------------------
12
PsiBlast_PDB
53.44
42%
-114
- C1 -
-
3SKY
1
A:
[5-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
F
E
R
A
K
D
L
Q
A
V
I
F
D
K
T
G
T
L
T
E
G
R
F
G
V
T
D
I
-
V
G
F
N
H
S
-------------------
E
D
E
L
L
Q
I
A
A
S
L
E
----------------
A
R
S
E
H
P
I
A
A
A
I
V
E
E
A
E
K
R
G
F
G
L
---------
T
E
V
E
E
F
R
A
I
P
G
K
G
V
E
G
I
V
N
------
G
--
R
R
Y
M
V
V
S
P
G
Y
I
R
E
L
G
I
K
T
--------------
D
E
S
---
V
-
E
K
L
K
Q
Q
G
K
T
V
V
F
I
L
K
N
------------------------
G
E
V
S
G
V
I
A
L
A
D
R
I
R
P
E
S
R
E
A
I
S
K
L
K
A
I
G
I
K
C
M
M
L
T
G
D
N
R
F
V
A
K
W
V
A
E
E
L
G
L
D
-----------------------------------------------------
D
Y
F
A
E
V
L
P
H
E
K
A
E
K
V
K
E
V
Q
Q
K
Y
-
V
T
A
M
V
G
D
G
V
N
D
A
P
A
L
A
Q
A
D
V
G
I
A
I
G
-
A
G
T
D
V
A
V
E
T
A
D
I
V
L
V
R
---
N
D
P
R
D
-
V
A
A
I
V
E
L
S
R
K
T
------------------------------------------------------------------
74
HHSearch
52.82
41%
-112
- C1 -
-
3SKY
1
A:
[5-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
F
E
R
A
K
D
L
Q
A
V
I
F
D
K
T
G
T
L
T
E
G
R
F
G
V
T
D
I
V
G
F
N
-
H
S
-------------------
E
D
E
L
L
Q
I
A
A
S
L
E
----------------
A
R
S
E
H
P
I
A
A
A
I
V
E
E
A
E
K
R
G
F
G
L
---------
T
E
V
E
E
F
R
A
I
P
G
K
G
V
E
G
I
V
N
------
G
--
R
R
Y
M
V
V
S
P
G
Y
I
R
E
L
G
I
K
-----------------
T
D
E
S
V
-
E
K
L
K
Q
Q
G
K
T
V
V
F
I
L
K
N
------------------------
G
E
V
S
G
V
I
A
L
A
D
R
I
R
P
E
S
R
E
A
I
S
K
L
K
A
I
G
I
K
C
M
M
L
T
G
D
N
R
F
V
A
K
W
V
A
E
E
L
G
L
D
-----------------------------------------------------
D
Y
F
A
E
V
L
P
H
E
K
A
E
K
V
K
E
V
Q
Q
-
K
Y
V
T
A
M
V
G
D
G
V
N
D
A
P
A
L
A
Q
A
D
V
G
I
A
I
G
-
A
G
T
D
V
A
V
E
T
A
D
I
V
L
V
R
---
N
D
P
R
D
-
V
A
A
I
V
E
L
S
R
K
T
Y
S
----------------------------------------------------------------
24
PsiBlast_CBE
49.10
44%
-37
- C1 -
-
3A1D
1
?
B:
[13-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
N
G
D
E
-------------------
R
-
E
L
L
R
L
A
A
I
A
E
----------------
R
R
S
E
H
P
I
A
E
A
I
V
K
K
A
L
E
H
G
I
E
L
---------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
D
------------
G
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
V
--------------
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
A
V
I
V
A
R
N
------------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
E
-
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
---
D
D
L
R
D
-
V
V
A
A
I
Q
L
S
R
K
T
M
S
----------------------------------------------------------------
25
PsiBlast_CBE
48.61
44%
-38
- C1 -
-
3A1C
1
?
B:
[14-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
N
G
D
E
-------------------
R
-
E
L
L
R
L
A
A
I
A
E
----------------
R
R
S
E
H
P
I
A
E
A
I
V
K
K
A
L
E
H
G
I
E
L
---------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
D
------------
G
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
V
--------------
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
A
V
I
V
A
R
N
------------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
E
-
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
---
D
D
L
R
D
-
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
--------------------------------------------------------------
20
PsiBlast_PDB
48.40
30%
-99
- C1 -
-
2YJ4
1
?
A:
[13-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
P
I
V
T
Q
F
I
G
D
S
------------------------
L
S
L
A
Y
A
A
S
V
E
----------------
A
L
S
S
H
P
I
A
K
A
I
V
K
Y
A
K
E
Q
G
V
K
I
---------
L
E
V
K
D
F
K
E
I
S
G
I
G
V
R
G
K
I
S
------
D
--
K
I
I
E
V
K
K
-------------------------------------
A
E
N
--
D
I
A
V
Y
I
N
------------------------
G
E
P
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
Q
-----------------------------------------------------
E
Y
Y
S
N
L
S
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
G
-
N
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
ND
I
G
T
L
L
G
L
I
K
N
--------------------------------------------------------------------------
26
PsiBlast_CBE
48.39
44%
-37
- C1 -
-
3A1E
1
B:
[13-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
N
G
D
E
-------------------
R
-
E
L
L
R
L
A
A
I
A
E
----------------
R
R
S
E
Q
P
I
A
E
A
I
V
K
K
A
L
E
H
G
I
E
L
---------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
D
------------
G
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
V
--------------
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
A
V
I
V
A
R
N
------------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
E
-
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
---
D
D
L
R
D
-
V
V
A
A
I
Q
L
S
R
K
T
M
S
----------------------------------------------------------------
10
PsiBlast_PDB
47.98
44%
-35
- C1 -
-
3A1E
1
COPA_ARCFU
A:
[14-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
N
G
D
E
-------------------
R
-
E
L
L
R
L
A
A
I
A
E
----------------
R
R
S
E
Q
P
I
A
E
A
I
V
K
K
A
L
E
H
G
I
E
L
---------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
D
------------
G
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
V
--------------
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
A
V
I
V
A
R
N
------------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
E
-
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
---
D
D
L
R
D
-
V
V
A
A
I
Q
L
S
R
K
-------------------------------------------------------------------
8
PsiBlast_PDB
47.93
44%
-37
- C1 -
-
3A1C
1
?
A:
[14-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
N
G
D
E
-------------------
R
-
E
L
L
R
L
A
A
I
A
E
----------------
R
R
S
E
H
P
I
A
E
A
I
V
K
K
A
L
E
H
G
I
E
L
---------
G
E
P
E
K
V
E
V
I
A
G
E
G
V
V
A
D
------------
G
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
V
--------------
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
A
V
I
V
A
R
N
------------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
E
-
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
---
D
D
L
R
D
-
V
V
A
A
I
Q
L
S
R
--------------------------------------------------------------------