@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLK7: (2017-11-03 )
MTIKRALISVSDKTGIVEFAQNLAALGVELLSTGGTYKLLKDNNIAVVEVSEHTGFPEMMDGRVKTLHPKIHGGILARRGLDEAVMQEHNIDPIDLVVVNLYPFAATVAKPNCSLADAIENIDIGGPTMVRAAAKNHASVGIVVNASDYDTVISELKASGSLSYETRFDLAVKAFEHTAQYDGMIASYLGARVGKAEGEADLFPRTFNTQLNKAQDLRYGENPHQSAAFYVEANAKEASVSTAKQLQGKELSYNNIADTDAALECVKSFAKPACVIVKHANPCGVAVSLDGIKAAYDLAYATDPESAFGGIIAFNRELDVATAQAIVDRQFVEVIIAPSIADGVLEVTGAKKNVRVLVCGELPAIDARAPQLDYKRVNGGLLVQDQDLGMITKDDLKVVTKRAPTEQEIDDLIFAWKVAKYVKSNAIVYAKNRQTIGVGAGQMSRVNSARIAAIKAEHAGLVVEGAVMASDAFFPFRDGIDNAAKAGIKCIIQPGGSMRDEEVIAAADEAGIAMVFTGMRHFRH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70-.......--..-80........90........100.......110.......120.......130.......140.......150.......--160-........170.......180.......190.......200.......210.......220......-.230.......240.......250.......260.......270---........280.....-------------------..290-----------------.........300.......310.......320.......330.......340.......350--.......360.......370.......380........390---..---..-.---..400........410.......420.......430.......440.......450.......-------------460-----------------------------------------------.........470.......480.......490.......500.......510.......520..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MT
I
K
R
A
L
ISVSDKT
G
I
V
E
F
A
Q
N
L
A
A
L
G
V
E
L
LSTGG
T
Y
K
L
LKDN
N
I
A
V
V
E
VSEHTG
F
P
E
MMDGR
V
K
T
LHPK--IH
G
G
I
L
A
--RR-GL
D
E
A
V
M
Q
EHNIDP
I
D
L
V
V
V
NLYPFAATVAKPNC
S
L
A
D
A
I
E
NIDIGG
P
T
M
V
R
A
A
AKNH
A
S
V
G
I
V
V
NA
S
D
Y
D
T
V
I
S
E
L
K
AS--GS--L
S
Y
E
T
R
F
D
L
A
V
K
A
F
E
H
T
A
Q
Y
D
G
M
I
A
S
Y
L
G
A
RVGKAEGEADLFPR
T
F
NTQLNKAQDLRYGENPHQ
S
A
A
-
F
Y
V
E
ANAKEAS
V
S
T
A
K
QLQGKELSYNNIAD
T
D
A
A
L
E
C
V
K
S
FAK----
P
A
C
V
I
V
KHANPC
G
V
A
V
-------------------
S
LD-------------------GI
K
A
A
Y
D
L
A
YATDPESAFG
G
I
I
A
FNREL
D
V
A
T
A
Q
A
I
V
D
R
Q
F
V
E
V
IIAPSIAD
G
V
L
E
VTGAKK--
N
V
R
V
L
V
CGELPAIDARAPQL
D
Y
K
RVNG
G
L
-
L
V
QDQDLGMI
T
---
K
D
---
D
L
-
K
---
V
V
TK-RAP
T
E
Q
E
I
D
D
L
I
F
A
W
K
V
A
K
Y
V
KSN
A
I
V
Y
AKN
R
Q
T
I
GVGAGQMSRVNS
A
R
I
A
A
I
KAEHA-------------
G
-------------------------------------------------
L
V
V
E
G
A
V
MASDAFF
P
F
RDGI
D
N
A
A
K
AG
I
K
C
I
IQPGGSMR
D
E
E
V
I
AAADEAG
I
A
M
V
F
T
G
M
R
H
FRH
21
PsiBlast_CBE
77.94
45%
-9
- C7 -
-
4A1O
2
PUR9_MYCTU
B:
[10-523]
--
I
R
R
A
L
I
S
V
Y
D
K
T
G
L
V
D
L
A
Q
G
L
S
A
A
G
V
E
I
I
S
T
G
S
T
A
K
T
I
A
D
T
G
I
P
V
T
P
V
E
Q
L
T
G
F
P
E
V
L
D
G
R
V
K
T
L
H
P
R
--
V
H
A
G
L
L
A
DL
R
K
-
S
E
H
A
A
A
L
E
Q
L
G
I
E
A
F
E
L
V
V
V
N
L
Y
P
F
S
Q
T
V
-
E
S
G
A
S
V
D
D
C
V
E
Q
I
D
I
G
G
P
A
M
V
R
A
A
A
K
N
H
P
S
A
A
V
V
T
D
P
L
G
Y
H
G
V
L
A
A
L
R
A
---
G
G
--
F
T
L
A
E
R
K
R
L
A
S
L
A
F
Q
H
I
A
E
Y
D
I
A
V
A
S
W
M
Q
Q
T
L
A
P
-
E
H
P
V
A
A
F
P
Q
W
F
G
R
S
W
R
R
V
A
M
L
R
Y
G
E
N
P
H
Q
Q
A
A
-
L
Y
G
D
P
T
A
W
P
-
G
L
A
Q
A
E
Q
L
H
G
K
D
M
S
Y
N
N
F
T
D
A
D
A
A
W
R
A
A
F
D
H
E
Q
----
T
C
V
A
I
I
K
H
A
N
P
C
G
I
A
I
-------------------
S
S
V
-------------------
S
V
A
D
A
H
R
K
A
H
E
C
D
P
L
S
A
Y
G
G
V
I
A
A
N
T
E
V
S
V
E
M
A
E
-
Y
V
S
T
I
F
T
E
V
I
V
A
P
G
Y
A
P
G
A
L
D
V
L
A
R
K
K
--
N
I
R
V
L
V
A
A
E
-----
P
L
A
G
G
S
E
L
R
P
I
S
G
G
L
-
L
I
Q
Q
S
D
Q
L
D
A
H
---
G
D
NPA
N
W
-
T
---
L
A
T
G
-
S
P
A
D
P
A
T
L
T
D
L
V
F
A
W
R
A
C
R
A
V
K
S
N
A
I
V
I
A
A
D
G
A
T
V
G
V
G
M
G
Q
V
N
R
V
D
A
A
R
L
A
---
V
E
R
G
-------------
G
-------------------------------------------------
E
R
V
R
G
A
V
A
A
S
D
A
F
F
P
F
P
D
G
L
E
T
L
A
A
A
G
V
T
A
V
V
H
P
G
G
S
V
R
D
E
E
V
T
E
A
A
A
K
A
G
V
T
L
Y
L
T
G
A
R
H
F
A
H
2
PsiBlast_PDB
77.81
45%
-13
- C7 -
-
4A1O
3
PUR9_MYCTU
A:
[10-523]
--
I
R
R
A
L
I
S
V
Y
D
K
T
G
L
V
D
L
A
Q
G
L
S
A
A
G
V
E
I
I
S
T
G
S
T
A
K
T
I
A
D
T
G
I
P
V
T
P
V
E
Q
L
T
G
F
P
---
D
G
R
V
K
T
L
H
P
R
--
V
H
A
G
L
L
A
DL
R
K
-
S
E
H
A
A
A
L
E
Q
L
G
I
E
A
F
E
L
V
V
V
N
L
Y
P
F
S
Q
T
V
-
E
S
G
A
S
V
D
D
C
V
E
Q
I
D
I
G
G
P
A
M
V
R
A
A
A
K
N
H
P
S
A
A
V
V
T
D
P
L
G
Y
H
G
V
L
A
A
L
R
A
---
G
G
--
F
T
L
A
E
R
K
R
L
A
S
L
A
F
Q
H
I
A
E
Y
D
I
A
V
A
S
W
M
Q
Q
T
L
A
P
-
E
H
P
V
A
A
F
P
Q
W
F
G
R
S
W
R
R
V
A
M
L
R
Y
G
E
N
P
H
Q
Q
A
A
-
L
Y
G
D
P
T
A
W
P
-
G
L
A
Q
A
E
Q
L
H
G
K
D
M
S
Y
N
N
F
T
D
A
D
A
A
W
R
A
A
F
D
H
E
Q
----
T
C
V
A
I
I
K
H
A
N
P
C
G
I
A
I
-------------------
S
S
V
-------------------
S
V
A
D
A
H
R
K
A
H
E
C
D
P
L
S
A
Y
G
G
V
I
A
A
N
T
E
V
S
V
E
M
A
E
-
Y
V
S
T
I
F
T
E
V
I
V
A
P
G
Y
A
P
G
A
L
D
V
L
A
R
K
K
--
N
I
R
V
L
V
A
A
E
-----
P
L
A
G
G
S
E
L
R
P
I
S
G
G
L
-
L
I
Q
Q
S
D
Q
L
D
A
H
---
G
D
NPA
N
W
-
T
---
L
A
T
G
-
S
P
A
D
P
A
T
L
T
D
L
V
F
A
W
R
A
C
R
A
V
K
S
N
A
I
V
I
A
A
D
G
A
T
V
G
V
G
M
G
Q
V
N
R
V
D
A
A
R
L
A
---
V
E
R
G
-------------
G
-------------------------------------------------
E
R
V
R
G
A
V
A
A
S
D
A
F
F
P
F
P
D
G
L
E
T
L
A
A
A
G
V
T
A
V
V
H
P
G
G
S
V
R
D
E
E
V
T
E
A
A
A
K
A
G
V
T
L
Y
L
T
G
A
R
H
F
A
H
22
PsiBlast_CBE
77.47
45%
-13
- C7 -
-
3ZZM
2
PUR9_MYCTU
B:
[10-523]
--
I
R
R
A
L
I
S
V
Y
D
K
T
G
L
V
D
L
A
Q
G
L
S
A
A
G
V
E
I
I
S
T
G
S
T
A
K
T
I
A
D
T
G
I
P
V
T
P
V
E
Q
L
T
G
F
P
E
V
L
D
G
R
V
K
T
L
H
P
R
--
V
H
A
G
L
L
A
DL
R
K
-
S
E
H
A
A
A
L
E
Q
L
G
I
E
A
F
E
L
V
V
V
N
L
Y
P
F
S
Q
T
V
-
E
S
G
A
S
V
D
D
C
V
E
Q
I
D
I
G
G
P
A
M
V
R
A
A
A
K
N
H
P
S
A
A
V
V
T
D
P
L
G
Y
H
G
V
L
A
A
L
R
A
---
G
G
--
F
T
L
A
E
R
K
R
L
A
S
L
A
F
Q
H
I
A
E
Y
D
I
A
V
A
S
W
M
Q
Q
T
L
A
P
-
E
H
P
V
A
A
F
P
Q
W
F
G
R
S
W
R
R
V
A
M
L
R
Y
G
E
N
P
H
Q
Q
A
A
-
L
Y
G
D
P
T
A
W
P
-
G
L
A
Q
A
E
Q
L
H
G
K
D
M
S
Y
N
N
F
T
D
A
D
A
A
W
R
A
A
F
D
H
E
Q
----
T
C
V
A
I
I
K
H
A
N
P
C
G
I
A
I
-------------------
S
S
V
-------------------
S
V
A
D
A
H
R
K
A
H
E
C
D
P
L
S
A
Y
G
G
V
I
A
A
N
T
E
V
S
V
E
M
A
E
-
Y
V
S
T
I
F
T
E
V
I
V
A
P
G
Y
A
P
G
A
L
D
V
L
A
R
K
K
--
N
I
R
V
L
V
A
A
E
-----
P
L
A
G
G
S
E
L
R
P
I
S
G
G
L
-
L
I
Q
Q
S
D
Q
L
D
A
H
---
G
D
NPA
N
W
-
T
---
L
A
T
G
-
S
P
A
D
P
A
T
L
T
D
L
V
F
A
W
R
A
C
R
A
V
K
S
N
A
I
V
I
A
A
D
G
A
T
V
G
V
G
M
G
Q
V
N
R
V
D
A
A
R
L
A
---
V
E
R
G
-------------
G
-------------------------------------------------
E
R
V
R
G
A
V
A
A
S
D
A
F
F
P
F
P
D
G
L
E
T
L
A
A
A
G
V
T
A
V
V
H
P
G
G
S
V
R
D
E
E
V
T
E
A
A
A
K
A
G
V
T
L
Y
L
T
G
A
R
H
F
A
H
1
PsiBlast_PDB
77.42
45%
-13
- C7 -
-
3ZZM
2
PUR9_MYCTU
A:
[10-523]
--
I
R
R
A
L
I
S
V
Y
D
K
T
G
L
V
D
L
A
Q
G
L
S
A
A
G
V
E
I
I
S
T
G
S
T
A
K
T
I
A
D
T
G
I
P
V
T
P
V
E
Q
L
T
G
F
P
E
V
L
D
G
R
V
K
T
L
H
P
R
--
V
H
A
G
L
L
A
DL
R
K
-
S
E
H
A
A
A
L
E
Q
L
G
I
E
A
F
E
L
V
V
V
N
L
Y
P
F
S
Q
T
V
-
E
S
G
A
S
V
D
D
C
V
E
Q
I
D
I
G
G
P
A
M
V
R
A
A
A
K
N
H
P
S
A
A
V
V
T
D
P
L
G
Y
H
G
V
L
A
A
L
R
A
---
G
G
--
F
T
L
A
E
R
K
R
L
A
S
L
A
F
Q
H
I
A
E
Y
D
I
A
V
A
S
W
M
Q
Q
T
L
A
P
-
E
H
P
V
A
A
F
P
Q
W
F
G
R
S
W
R
R
V
A
M
L
R
Y
G
E
N
P
H
Q
Q
A
A
-
L
Y
G
D
P
T
A
W
P
-
G
L
A
Q
A
E
Q
L
H
G
K
D
M
S
Y
N
N
F
T
D
A
D
A
A
W
R
A
A
F
D
H
E
Q
----
T
C
V
A
I
I
K
H
A
N
P
C
G
I
A
I
-------------------
S
S
V
-------------------
S
V
A
D
A
H
R
K
A
H
E
C
D
P
L
S
A
Y
G
G
V
I
A
A
N
T
E
V
S
V
E
M
A
E
-
Y
V
S
T
I
F
T
E
V
I
V
A
P
G
Y
A
P
G
A
L
D
V
L
A
R
K
K
--
N
I
R
V
L
V
A
A
E
-----
P
L
A
G
G
S
E
L
R
P
I
S
G
G
L
-
L
I
Q
Q
S
D
Q
L
D
A
H
---
G
D
NPA
N
W
-
T
---
L
A
T
G
-
S
P
A
D
P
A
T
L
T
D
L
V
F
A
W
R
A
C
R
A
V
K
S
N
A
I
V
I
A
A
D
G
A
T
V
G
V
G
M
G
Q
V
N
R
V
D
A
A
R
L
A
---
V
E
R
G
-------------
G
-------------------------------------------------
E
R
V
R
G
A
V
A
A
S
D
A
F
F
P
F
P
D
G
L
E
T
L
A
A
A
G
V
T
A
V
V
H
P
G
G
S
V
R
D
E
E
V
T
E
A
A
A
K
A
G
V
T
L
Y
L
T
G
A
R
H
F
A
H
40
HHSearch
76.20
45%
-15
- C7 -
-
3ZZM
2
PUR9_MYCTU
A:
[9-523]
-
P
I
R
R
A
L
I
S
V
Y
D
K
T
G
L
V
D
L
A
Q
G
L
S
A
A
G
V
E
I
I
S
T
G
S
T
A
K
T
I
A
D
T
G
I
P
V
T
P
V
E
Q
L
T
G
F
P
E
V
L
D
G
R
V
K
T
L
H
P
R
V
H
A
G
L
L
A
D
L
--
R
K
-
S
E
H
A
A
A
L
E
Q
L
G
I
E
A
F
E
L
V
V
V
N
L
Y
P
F
S
Q
T
V
E
S
-
G
A
S
V
D
D
C
V
E
Q
I
D
I
G
G
P
A
M
V
R
A
A
A
K
N
H
P
S
A
A
V
V
T
D
P
L
G
Y
H
G
V
L
A
A
L
R
A
---
G
G
--
F
T
L
A
E
R
K
R
L
A
S
L
A
F
Q
H
I
A
E
Y
D
I
A
V
A
S
W
M
Q
Q
T
L
A
P
E
H
P
V
-
A
A
F
P
Q
W
F
G
R
S
W
R
R
V
A
M
L
R
Y
G
E
N
P
H
Q
Q
A
A
-
L
Y
G
D
-
P
T
A
W
P
G
L
A
Q
A
E
Q
L
H
G
K
D
M
S
Y
N
N
F
T
D
A
D
A
A
W
R
A
A
F
D
H
E
Q
----
T
C
V
A
I
I
K
H
A
N
P
C
G
I
A
I
-------------------
S
S
V
-------------------
S
V
A
D
A
H
R
K
A
H
E
C
D
P
L
S
A
Y
G
G
V
I
A
A
N
T
E
V
S
V
E
M
A
E
Y
V
S
-
T
I
F
T
E
V
I
V
A
P
G
Y
A
P
G
A
L
D
V
L
A
R
K
K
--
N
I
R
V
L
V
A
A
E
P
L
A
-----
G
G
S
E
L
R
P
I
S
G
G
L
-
L
I
Q
Q
S
D
Q
L
D
A
H
GDN
P
A
---
N
W
-
T
---
L
A
T
G
-
S
P
A
D
P
A
T
L
T
D
L
V
F
A
W
R
A
C
R
A
V
K
S
N
A
I
V
I
A
A
D
G
A
T
V
G
V
G
M
G
Q
V
N
R
V
D
A
A
R
L
A
V
E
R
G
-
G
----------------------------------------------------------------
E
R
V
R
G
A
V
A
A
S
D
A
F
F
P
F
P
D
G
L
E
T
L
A
A
A
G
V
T
A
V
V
H
P
G
G
S
V
R
D
E
E
V
T
E
A
A
A
K
A
G
V
T
L
Y
L
T
G
A
R
H
F
A
H
3
PsiBlast_PDB
75.69
45%
-42
- C7 -
-
4EHI
1
PUR9_CAMJE
A:
[26-534]
----
R
A
L
L
S
V
S
D
K
E
G
I
V
E
F
G
K
E
L
E
N
L
G
F
E
I
L
S
T
G
G
T
F
K
L
L
K
E
N
G
I
K
V
I
E
V
S
D
F
T
-----------------------------------------
I
L
G
I
D
L
V
C
V
N
L
Y
P
F
K
K
T
T
I
M
S
D
-
D
F
D
E
I
I
E
N
I
D
I
G
G
P
A
M
I
R
S
A
A
K
N
Y
K
D
V
M
V
L
C
D
P
L
D
Y
E
K
V
I
E
T
L
K
-
K
--
G
Q
--
N
D
E
N
F
R
L
N
L
M
I
K
A
Y
E
H
T
A
N
Y
D
A
Y
I
A
N
Y
M
N
E
R
F
N
G
G
F
G
A
S
K
F
I
V
G
Q
------
K
V
F
D
T
K
Y
G
E
N
P
H
Q
K
G
A
-
L
Y
-
E
F
D
A
F
F
S
A
--
N
F
K
A
L
K
G
-
E
A
S
F
N
N
L
T
D
I
N
A
A
L
N
L
A
S
S
F
D
K
A---
P
A
I
A
I
V
K
H
G
N
P
C
G
F
A
I
-------------------
K
-
E
-------------------
N
L
V
Q
S
Y
I
H
A
L
K
C
D
S
V
S
A
Y
G
G
V
V
A
I
N
G
T
L
D
E
A
L
A
N
K
I
-
N
E
I
Y
V
E
V
I
I
A
A
N
V
D
E
K
A
L
A
V
F
E
G
K
K
--
R
I
K
I
F
T
-
Q
E
S
P
F
L
I
R
S
F
D
K
Y
D
F
K
H
I
D
G
G
F
-
V
Y
Q
N
S
D
--
E
V
G
---
E
D
---
E
L
-
K
NAK
L
M
S
Q
-
R
E
A
S
K
E
E
L
K
D
L
E
I
A
M
K
I
A
A
F
T
K
S
N
N
V
V
Y
V
K
N
G
A
M
V
A
I
G
M
G
M
T
S
R
I
D
A
A
K
A
A
I
A
K
A
K
E
M
-------------
G
-------------------------------------------------
L
D
L
Q
G
C
V
L
A
S
E
A
F
F
P
F
R
D
S
I
D
E
A
S
K
V
G
V
K
A
I
V
E
P
G
G
S
I
R
D
D
E
V
V
K
A
A
D
E
Y
G
M
A
L
Y
F
T
G
V
R
H
F
L
H
41
HHSearch
75.68
45%
-55
- C7 -
-
4EHI
1
PUR9_CAMJE
A:
[23-534]
-
N
A
M
R
A
L
L
S
V
S
D
K
E
G
I
V
E
F
G
K
E
L
E
N
L
G
F
E
I
L
S
T
G
G
T
F
K
L
L
K
E
N
G
I
K
V
I
E
V
S
D
F
T
-----------------------------------------
I
L
G
I
D
L
V
C
V
N
L
Y
P
F
K
K
T
T
I
M
-
S
D
D
F
D
E
I
I
E
N
I
D
I
G
G
P
A
M
I
R
S
A
A
K
N
Y
K
D
V
M
V
L
C
D
P
L
D
Y
E
K
V
I
E
T
L
K
K
---
G
Q
--
N
D
E
N
F
R
L
N
L
M
I
K
A
Y
E
H
T
A
N
Y
D
A
Y
I
A
N
Y
M
N
E
R
F
N
G
------
G
F
G
A
S
K
F
I
V
G
Q
K
V
F
D
T
K
Y
G
E
N
P
H
Q
K
G
A
-
L
Y
E
F
-
D
A
F
--
F
S
A
N
F
K
A
L
K
G
-
E
A
S
F
N
N
L
T
D
I
N
A
A
L
N
L
A
S
S
F
D
K
A---
P
A
I
A
I
V
K
H
G
N
P
C
G
F
A
I
-------------------
K
E
--------------------
N
L
V
Q
S
Y
I
H
A
L
K
C
D
S
V
S
A
Y
G
G
V
V
A
I
N
G
T
L
D
E
A
L
A
N
K
I
N
-
E
I
Y
V
E
V
I
I
A
A
N
V
D
E
K
A
L
A
V
F
E
G
K
K
--
R
I
K
I
F
T
Q
E
S
P
F
L
I
-
R
S
F
D
K
Y
D
F
K
H
I
D
G
G
F
-
V
Y
Q
N
S
D
E
V
G
E
D
E--
L
K
---
N
A
-
K
---
L
M
S
Q
-
R
E
A
S
K
E
E
L
K
D
L
E
I
A
M
K
I
A
A
F
T
K
S
N
N
V
V
Y
V
K
N
G
A
M
V
A
I
G
M
G
M
T
S
R
I
D
A
A
K
A
A
I
A
K
A
K
E
M
-------------
G
-------------------------------------------------
L
D
L
Q
G
C
V
L
A
S
E
A
F
F
P
F
R
D
S
I
D
E
A
S
K
V
G
V
K
A
I
V
E
P
G
G
S
I
R
D
D
E
V
V
K
A
A
D
E
Y
G
M
A
L
Y
F
T
G
V
R
H
F
L
H
43
HHSearch
73.85
39%
-22
- C7 -
-
1G8M
-
PUR9_CHICK
B:
[4-593]
-
R
Q
Q
L
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V-
H
A
G
I
L
A
R
--
N
I
-
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
A
A
S
KD
K
D
--
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
F
R
K
E
Y
S
---------------
K
G
V
S
Q
L
P
L
R
Y
G
M
N
P
H
Q
S
P
A
-
Q
L
Y
T
-
T
R
---
P
K
L
P
L
T
V
V
N
G
S
P
-
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
Q
ALGI
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
-------------------
G
I
P
LSEEEAQVCMVHDLHKTLT
P
L
A
S
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
-
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
NG
G
Y
C
V
L
Q
M
D
P
N
Y
E
P
----
D
D
N
E
I
R
T
L
Y
G
L
Q
-
L
M
Q
K
R
N
N
A
V
I
D
---
R
S
---
L
F
-
K
NI-
V
T
K
N
-
K
T
L
P
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
S
W
WLRHHPRVLSMKF
K
AGVKRAEVSNAIDQYVTGTIGEDEDLVKWQAMFEEVPAQLTEAEKKQWI
A
K
L
T
A
V
S
L
S
S
D
A
F
F
P
F
R
D
N
V
D
R
A
K
R
I
G
V
Q
F
I
V
A
P
S
G
S
A
A
D
E
V
V
I
E
A
C
N
E
L
G
I
T
L
I
H
T
N
L
R
L
F
H
H
44
HHSearch
73.17
39%
-19
- C7 -
-
2B1G
1
PUR9_CHICK
D:
[4-593]
-
R
Q
Q
L
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V-
H
A
G
I
L
A
R
--
N
I
-
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
A
A
S
KD
K
D
--
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
F
R
K
E
Y
S
---------------
K
G
V
S
Q
L
P
L
R
Y
G
M
N
P
H
Q
S
P
A
-
Q
L
Y
T
-
T
R
---
P
K
L
P
L
T
V
V
N
G
S
P
-
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
Q
ALGI
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
-------------------
G
I
P
LSEEEAQVCMVHDLHKTLT
P
L
A
S
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
-
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
NG
G
Y
C
V
L
Q
M
D
P
N
Y
E
P
----
D
D
N
E
I
R
T
L
Y
G
L
Q
-
L
M
Q
K
R
N
N
A
V
I
D
---
R
S
---
L
F
-
K
NI-
V
T
K
N
-
K
T
L
P
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
S
W
WLRHHPRVLSMKF
K
AGVKRAEVSNAIDQYVTGTIGEDEDLVKWQAMFEEVPAQLTEAEKKQWI
A
K
L
T
A
V
S
L
S
S
D
A
F
F
P
F
R
D
N
V
D
R
A
K
R
I
G
V
Q
F
I
V
A
P
S
G
S
A
A
D
E
V
V
I
E
A
C
N
E
L
G
I
T
L
I
H
T
N
L
R
L
F
H
H
42
HHSearch
71.95
45%
1
- C7 -
-
4EHI
-
PUR9_CAMJE
B:
[23-534]
-
N
A
M
R
A
L
L
S
V
S
D
K
E
G
I
V
E
F
G
K
E
L
E
N
L
G
F
E
I
L
S
T
G
G
T
F
K
L
L
K
E
N
G
I
K
V
I
E
V
S
D
F
T
K
S
-------
V
K
T
L
H
P
K
IH
G
G
I
L
H
K
R
--
S
D
-
E
N
H
I
K
Q
--
E
N
E
I
L
G
I
D
L
V
C
V
N
L
Y
-----------
D
F
D
E
I
I
E
N
I
D
I
G
G
P
A
M
I
R
S
A
A
K
N
Y
K
D
V
M
V
L
C
D
P
L
D
Y
E
K
V
I
E
T
L
K
K
---
G
Q
--
N
D
E
N
F
R
L
N
L
M
I
K
A
Y
E
H
T
A
N
Y
D
A
Y
I
A
N
Y
M
N
E
R
F
N
G
------
G
F
G
A
S
K
F
I
V
G
Q
K
V
F
D
T
K
Y
G
E
N
P
H
Q
K
G
A
-
L
Y
E
F
-
D
A
F
--
F
S
A
N
F
K
A
L
K
G
-
E
A
S
F
N
N
L
T
D
I
N
A
A
L
N
L
A
S
S
F
D
K
A---
P
A
I
A
I
V
K
H
G
N
P
C
G
F
A
I
-------------------
K
E
--------------------
N
L
V
Q
S
Y
I
H
A
L
K
C
D
S
V
S
A
Y
G
G
V
V
A
I
N
G
T
L
D
E
A
L
A
N
K
I
N
-
E
I
Y
V
E
V
I
I
A
A
N
V
D
E
K
A
L
A
V
F
E
G
K
K
--
R
I
K
I
F
T
Q
E
S
P
F
L
I
-
R
S
F
D
K
Y
D
F
K
H
I
D
G
G
F
-
V
Y
Q
N
S
D
E
V
G
E
D
E--
L
K
---
N
A
-
K
---
L
M
S
Q
-
R
E
A
S
K
E
E
L
K
D
L
E
I
A
M
K
I
A
A
F
T
K
S
N
N
V
V
Y
V
K
N
G
A
M
V
A
I
G
M
G
M
T
S
R
I
D
A
A
K
A
A
I
A
K
A
K
E
M
-------------
G
-------------------------------------------------
L
D
L
Q
G
C
V
L
A
S
E
A
F
F
P
F
R
D
S
I
D
E
A
S
K
V
G
V
K
A
I
V
E
P
G
G
S
I
R
D
D
E
V
V
K
A
A
D
E
Y
G
M
A
L
Y
F
T
G
V
R
H
F
L
H
25
PsiBlast_CBE
67.03
39%
-22
- C7 -
-
1P4R
4
PUR9_HUMAN
B:
[7-485]
-----
A
L
F
S
V
S
D
K
T
G
L
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
G
L
A
V
R
D
V
S
E
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
--
V
H
A
G
I
L
A
--
R
N
I
P
E
D
N
A
D
M
A
R
L
D
F
N
L
I
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
S
P
G
V
T
V
E
E
A
V
E
Q
I
D
I
G
G
V
T
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Y
V
V
V
S
T
E
M
Q
S
S
--
E
S
KD
T
S
L
E
T
R
R
Q
L
A
L
K
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
F
R
K
Q
Y
S
K
G
V
S
Q
---------------
M
P
L
R
Y
G
M
N
P
H
Q
T
P
A
-
Q
L
Y
T
L
Q
P
K
-
L
P
I
T
V
L
N
G
A
P
G
----
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
E
A
LG
I
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
GIPLS
E
D
E
A
K
V
C
MVYDLYK
T
L
T
-------------------
P
I
S
A
A
Y
A
R
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
S
D
V
C
D
V
P
T
A
K
-
I
I
S
R
E
V
S
D
G
I
I
A
P
G
Y
E
E
E
A
L
T
I
L
S
K
K
K
--
N
G
N
Y
C
V
---
L
Q
M
D
Q
S
Y
K
P
D
E
N
E
V
R
T
L
F
G
L
H
L
S
Q
K
R
N
N
G
V
V
D
---
K
S
---
L
F
S
N
---
V
V
T
K
N
K
D
L
P
E
S
A
L
R
D
L
I
V
A
T
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
N
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
Y
W
-------------
W
-------------------------------------------------
L
R
H
H
P
Q
V
L
S
----
M
K
F
K
T
G
V
K
R
A
-----------------------------------------
4
PsiBlast_PDB
66.17
39%
-22
- C7 -
-
1P4R
5
PUR9_HUMAN
A:
[7-485]
-----
A
L
F
S
V
S
D
K
T
G
L
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
G
L
A
V
R
D
V
S
E
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
--
V
H
A
G
I
L
A
--
R
N
I
P
E
D
N
A
D
M
A
R
L
D
F
N
L
I
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
S
P
G
V
T
V
E
E
A
V
E
Q
I
D
I
G
G
V
T
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Y
V
V
V
S
T
E
M
Q
S
S
--
E
S
KD
T
S
L
E
T
R
R
Q
L
A
L
K
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
F
R
K
Q
Y
S
K
G
V
S
Q
---------------
M
P
L
R
Y
G
M
N
P
H
Q
T
P
A
-
Q
L
Y
T
L
Q
P
K
-
L
P
I
T
V
L
N
G
A
P
G
----
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
E
A
LG
I
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
GIPLS
E
D
E
A
K
V
C
MVYDLYK
T
L
T
-------------------
P
I
S
A
A
Y
A
R
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
S
D
V
C
D
V
P
T
A
K
-
I
I
S
R
E
V
S
D
G
I
I
A
P
G
Y
E
E
E
A
L
T
I
L
S
K
K
K
--
N
G
N
Y
C
V
---
L
Q
M
D
Q
S
Y
K
P
D
E
N
E
V
R
T
L
F
G
L
H
L
S
Q
K
R
N
N
G
V
V
D
---
K
S
---
L
F
S
N
---
V
V
T
K
N
K
D
L
P
E
S
A
L
R
D
L
I
V
A
T
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
N
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
Y
W
-------------
W
-------------------------------------------------
L
R
H
H
P
Q
V
L
S
----
M
K
F
K
T
G
V
K
R
A
-----------------------------------------
6
PsiBlast_PDB
66.07
37%
-25
- C7 -
-
1THZ
2
PUR9_CHICK
A:
[8-486]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
--
V
H
A
G
I
L
A
--
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
A
A
S
KD
K
D
--
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
F
--
R
K
E
Y
S
K
G
V
S
Q
L
-------------
P
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
Q
A
LG
I
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
GIPLS
E
E
E
A
Q
V
C
MVHDLHK
T
L
T
-------------------
P
L
A
S
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
-
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
--
N
G
G
Y
C
V
L
Q
M
D
P
N
Y
E
---
P
D
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
R
N
N
A
V
I
D
---
R
S
---
L
F
-
K
N--
I
V
T
K
N
K
T
L
P
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
S
W
-------------
W
-------------------------------------------------
L
R
H
H
P
R
V
L
S
----
M
K
F
K
A
G
V
K
R
A
-----------------------------------------
5
PsiBlast_PDB
65.66
39%
-21
- C7 -
-
1PL0
3
PUR9_HUMAN
A:
[7-485]
-----
A
L
F
S
V
S
D
K
T
G
L
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
G
L
A
V
R
D
V
S
E
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
--
V
H
A
G
I
L
A
--
R
N
I
P
E
D
N
A
D
M
A
R
L
D
F
N
L
I
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
S
P
G
V
T
V
E
E
A
V
E
Q
I
D
I
G
G
V
T
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Y
V
V
V
S
T
E
M
Q
S
S
--
E
S
KD
T
S
L
E
T
R
R
Q
L
A
L
K
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
F
R
K
Q
Y
S
K
G
V
S
Q
---------------
M
P
L
R
Y
G
M
N
P
H
Q
T
P
A
-
Q
L
Y
T
L
Q
P
K
-
L
P
I
T
V
L
N
G
A
P
G
----
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
E
A
L
G
I
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
GIPLS
E
D
E
A
K
V
C
MVYDLYK
T
L
T
-------------------
P
I
S
A
A
Y
A
R
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
S
D
V
C
D
V
P
T
A
K
-
I
I
S
R
E
V
S
D
G
I
I
A
P
G
Y
E
E
E
A
L
T
I
L
S
K
K
K
--
N
G
N
Y
C
V
---
L
Q
M
D
Q
S
Y
K
P
D
E
N
E
V
R
T
L
F
G
L
H
L
S
Q
K
R
N
N
G
V
V
D
---
K
S
---
L
F
S
N
---
V
V
T
K
N
K
D
L
P
E
S
A
L
R
D
L
I
V
A
T
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
N
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
Y
W
-------------
W
-------------------------------------------------
L
R
H
H
P
Q
V
L
S
----
M
K
F
K
T
G
V
K
R
A
-----------------------------------------
8
PsiBlast_PDB
65.52
37%
-24
- C7 -
-
2B1I
4
PUR9_CHICK
A:
[8-486]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
--
V
H
A
G
I
L
A
--
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
A
A
S
KD
K
D
--
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
F
--
R
K
E
Y
S
K
G
V
S
Q
L
-------------
P
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
Q
A
LG
I
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
GIPLS
E
E
E
A
Q
V
C
MVHDLHK
T
L
T
-------------------
P
L
A
S
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
-
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
--
N
G
G
Y
C
V
L
Q
M
D
P
N
Y
E
---
P
D
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
R
N
N
A
V
I
D
---
R
S
---
L
F
-
K
N--
I
V
T
K
N
K
T
L
P
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
S
W
-------------
W
-------------------------------------------------
L
R
H
H
P
R
V
L
S
----
M
K
F
K
A
G
V
K
R
A
-----------------------------------------
27
PsiBlast_CBE
65.18
37%
-23
- C7 -
-
2IU0
1
PUR9_CHICK
B:
[8-486]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
--
V
H
A
G
I
L
A
--
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
A
A
S
KD
K
D
--
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
F
--
R
K
E
Y
S
K
G
V
S
Q
L
-------------
P
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
Q
ALGI
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
GIPLSEEEAQVCMVHDLHK
T
L
T
-------------------
P
L
A
S
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
-
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
--
N
G
G
Y
C
V
L
Q
M
D
P
N
Y
E
---
P
D
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
R
N
N
A
V
I
D
---
R
S
---
L
F
-
K
N--
I
V
T
K
N
K
T
L
P
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
S
W
-------------
W
-------------------------------------------------
L
R
H
H
P
R
V
L
S
----
M
K
F
K
A
G
V
K
R
A
-----------------------------------------
33
PsiBlast_CBE
65.11
37%
-22
- C7 -
-
1OZ0
2
PUR9_CHICK
B:
[28-506]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
--
V
H
A
G
I
L
A
--
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
A
A
S
KD
K
D
--
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
F
--
R
K
E
Y
S
K
G
V
S
Q
L
-------------
P
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
Q
ALGI
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
GIPLSEEEAQVCMVHDLHK
T
L
T
-------------------
P
L
A
S
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
-
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
--
N
G
G
Y
C
V
L
Q
M
D
P
N
Y
E
---
P
D
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
R
N
N
A
V
I
D
---
R
S
---
L
F
-
K
N--
I
V
T
K
N
K
T
L
P
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
S
W
-------------
W
-------------------------------------------------
L
R
H
H
P
R
V
L
S
----
M
K
F
K
A
G
V
K
R
A
-----------------------------------------
28
PsiBlast_CBE
65.09
37%
-22
- C7 -
-
2B1I
4
PUR9_CHICK
B:
[8-486]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
--
V
H
A
G
I
L
A
--
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
A
A
S
KD
K
D
--
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
F
--
R
K
E
Y
S
K
G
V
S
Q
L
-------------
P
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
Q
ALGI
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
GIPLSEEEAQVCMVHDLHK
T
L
T
-------------------
P
L
A
S
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
-
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
--
N
G
G
Y
C
V
L
Q
M
D
P
N
Y
E
---
P
D
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
R
N
N
A
V
I
D
---
R
S
---
L
F
-
K
N--
I
V
T
K
N
K
T
L
P
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
S
W
-------------
W
-------------------------------------------------
L
R
H
H
P
R
V
L
S
----
M
K
F
K
A
G
V
K
R
A
-----------------------------------------
32
PsiBlast_CBE
64.96
37%
-23
- C7 -
-
1THZ
2
PUR9_CHICK
B:
[8-486]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
--
V
H
A
G
I
L
A
--
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
A
A
S
KD
K
D
--
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
F
--
R
K
E
Y
S
K
G
V
S
Q
L
-------------
P
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
Q
ALGI
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
GIPLSEEEAQVCMVHDLHK
T
L
T
-------------------
P
L
A
S
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
-
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
--
N
G
G
Y
C
V
L
Q
M
D
P
N
Y
E
---
P
D
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
R
N
N
A
V
I
D
---
R
S
---
L
F
-
K
N--
I
V
T
K
N
K
T
L
P
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
S
W
-------------
W
-------------------------------------------------
L
R
H
H
P
R
V
L
S
----
M
K
F
K
A
G
V
K
R
A
-----------------------------------------
11
PsiBlast_PDB
64.94
37%
-21
- C7 -
-
1M9N
2
PUR9_CHICK
A:
[28-506]
-----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
--
V
H
A
G
I
L
A
--
R
N
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
A
A
S
KD
K
D
--
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
F
--
R
K
E
Y
S
K
G
V
S
Q
L
-------------
P
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
T
T
R
P
K
L
P
L
T
V
V
N
G
S
P
------
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
Q
A
LG
I
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
GIPLS
E
E
E
A
Q
V
C
MVHDLHK
T
L
T
-------------------
P
L
A
S
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
-
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
K
K
K
--
N
G
G
Y
C
V
L
Q
M
D
P
N
Y
E
---
P
D
D
N
E
I
R
T
L
Y
G
L
Q
L
M
Q
K
R
N
N
A
V
I
D
---
R
S
---
L
F
-
K
N--
I
V
T
K
N
K
T
L
P
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
S
W
-------------
W
-------------------------------------------------
L
R
H
H
P
R
V
L
S
----
M
K
F
K
A
G
V
K
R
A
-----------------------------------------