@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLL9: (2017-11-03 )
MEKLIITAAVNGGITPRSKNPAVPYTPEEIANAVYEVWNAGASVAHIHARNLDGSPSYQQEVWGEIVDKVRARCDIILNLSTSGLNLPLDAPKDQAWNHLVYRPEIASYNCGSVNHGSKPFINPPALAMELADAINQYGVKPEIEIYHSGVINEAETLHLKGYLKSPMLFAFAMGIHGGVTATCKNLIHLIDSLPAGSLWSALGIGKAQLPINVHTILLGGHVRTGLEDNIYYKAGELATSNAQLVERLVRLSHELDRPVASTQEARKILGLVS
Atome Classification :
(20 SA)
.........10........20........30........40........50-..-......60........70.-.-.-.....80..-...--...90-------------.......--------------..100.-.......110....--..------------------------.120--.......130.......140.......150.......160..-.-....170.......180---.....---.----.190----....---...200.......210.......220.......230.......240.......250.......260.......270..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
ME
K
L
I
I
T
A
AVNGGITPRSKNPAVPY
T
P
E
E
I
A
N
A
V
Y
E
V
W
NAGA
S
V
A
H
I
H
ARN-LD-GSP
S
Y
Q
Q
E
V
W
G
E
I
V
D
K
V
R
A
-R-
C
-
D
I
I
L
N
LSTS-GLN--LPLD--------------APKDQAW--------------N
H
L
V
-Y-RPEIASYNCGSVNH--GS------------------------KPFI--NP
P
A
L
A
M
E
L
A
D
A
I
N
QYGVKP
E
I
E
I
Y
HSGVINEA
E
T
L
H
L
KGYL-K-S
P
M
L
F
A
F
A
M
GIHGG
V
T
A
---
T
C
K
N
L
---
I
----
H
L
I
D----SLPA---
G
S
L
W
S
A
LGIGK
A
Q
L
P
I
N
V
H
T
I
L
LGGHVRTGLED
N
I
Y
Y
KAGELATS
N
A
Q
L
V
E
R
L
V
R
L
S
H
E
LDRPV
A
S
T
Q
E
A
R
K
I
L
GLVS
36
HHSearch
80.56
38%
-28
- C5 -
-
3CHV
-
?
A:
[7-280]
N
K
P
C
I
I
C
V
A
I
T
G
S
V
P
T
K
A
D
N
P
A
V
P
I
T
V
S
E
Q
V
E
S
T
Q
E
A
F
E
A
G
A
A
I
A
H
C
H
V
R
N
-
D
D
-
G
T
P
S
S
D
P
D
R
F
A
R
L
T
E
G
L
H
T
-
H
-
C
P
G
M
I
V
Q
F
S
T
G
-
G
R
S
--
G
A
G
------------------
Q
A
R
G
--------------
G
M
L
P
-
L
-
K
P
D
M
A
S
L
S
V
G
S
N
N
F
--
P
S
------------------------
R
V
Y
E
--
N
P
P
D
L
V
D
W
L
A
A
Q
M
R
S
Y
R
V
T
P
E
I
E
A
F
D
L
S
H
I
L
R
A
I
D
M
H
G
R
G
L
L
-
Y
-
G
K
L
Y
V
Q
F
V
M
G
V
K
N
A
M
P
A
---
D
R
E
V
F
---
D
----
F
Y
V
R
M
M
R
T
R
A
P
----
Q
A
E
W
C
A
A
G
I
G
A
N
Q
L
T
V
N
E
W
A
I
A
A
G
G
H
T
R
T
G
L
E
D
N
I
R
L
D
R
Q
T
L
A
P
S
N
A
A
L
V
R
R
S
V
E
L
C
D
K
Y
Q
R
P
V
A
S
W
Q
Q
A
R
E
I
L
G
L
P
A
5
PsiBlast_PDB
79.48
36%
-42
- C5 -
-
3CHV
-
?
A:
[10-278]
---
C
I
I
C
V
A
I
T
G
S
V
P
T
K
A
D
N
P
A
V
P
I
T
V
S
E
Q
V
E
S
T
Q
E
A
F
E
A
G
A
A
I
A
H
C
H
V
R
N
-
D
D
-
G
T
P
S
S
D
P
D
R
F
A
R
L
T
E
G
L
H
T
-
H
-
C
P
G
M
I
V
Q
F
S
T
G
-
G
R
S
--
G
A
G
Q
--------------
A
----
R
G
--------------
G
M
L
P
-
L
-
K
P
D
M
A
S
L
S
V
G
S
N
N
F
--
P
S
------------------------
R
V
Y
E
--
N
P
P
D
L
V
D
W
L
A
A
Q
M
R
S
Y
R
V
T
P
E
I
E
A
F
D
L
S
H
I
L
R
A
I
D
M
H
G
R
G
L
L
-
Y
-
G
K
L
Y
V
Q
F
V
M
G
V
K
N
A
M
P
A
---
D
R
E
V
F
D
F
Y
V
----
R
M
M
R
----
T
R
A
P
---
Q
A
E
W
C
A
A
G
I
G
A
N
Q
L
T
V
N
E
W
A
I
A
A
G
G
H
T
R
T
G
L
E
D
N
I
R
L
D
R
Q
T
L
A
P
S
N
A
A
L
V
R
R
S
V
E
L
C
D
K
Y
Q
R
P
V
A
S
W
Q
Q
A
R
E
I
L
G
L
--
33
HHSearch
78.30
32%
-41
- C5 -
-
3E49
4
?
B:
[5-305]
S
R
K
V
I
I
T
C
A
V
T
G
A
I
H
T
P
S
M
S
P
Y
L
P
V
T
P
D
E
V
A
Q
A
S
I
G
A
A
E
A
G
A
A
V
I
H
L
H
A
R
D
-
P
R
D
G
R
P
T
Q
D
P
A
A
F
A
E
F
L
P
R
I
K
S
-
N
-
T
-
D
A
V
I
N
L
T
T
G
-
G
S
P
--
H
M
T
----------------
V
-
E
E
R
L
--------------
R
P
A
T
-
H
Y
M
P
E
L
A
S
L
N
M
G
S
M
N
F
--
G
L
YPMLERFKEFAHGWEREHLERSRD
L
V
F
K
--
N
T
F
A
D
I
E
F
I
L
K
T
C
G
G
N
G
T
R
F
E
F
E
C
Y
D
T
S
H
L
Y
N
L
A
H
F
V
D
R
K
L
A
-
T
-
P
P
F
F
V
Q
T
V
F
G
L
L
G
G
I
G
P
---
H
P
E
D
L
---
A
----
H
M
R
R
TADR
L
F
G
A
---
D
Y
V
W
S
I
L
G
A
G
R
H
Q
I
P
L
A
S
I
G
A
A
Q
G
A
N
V
R
V
G
L
E
D
S
L
W
I
A
P
G
E
L
A
E
T
N
A
A
Q
V
R
K
I
R
Q
V
I
E
G
L
S
L
E
V
A
S
P
A
E
A
R
T
M
L
G
L
K
G
31
HHSearch
78.18
40%
-29
- C5 -
-
2Y7D
1
KCE_CLOAI
D:
[8-281]
-
E
P
L
I
L
T
A
A
I
T
G
A
E
T
T
R
A
D
Q
P
N
L
P
I
T
P
E
E
Q
A
K
E
A
K
A
C
F
E
A
G
A
R
V
I
H
L
H
I
R
E
-
D
D
-
G
R
P
S
Q
R
L
D
R
F
Q
E
A
I
S
A
I
R
E
-
V
-
V
P
E
I
I
I
Q
I
S
T
G
-
G
A
V
--
G
E
S
----------------
F
-
D
K
R
L
--------------
A
P
L
A
-
L
-
K
P
E
M
A
T
L
N
A
G
T
L
N
F
--
G
D
------------------------
D
I
F
I
--
N
H
P
A
D
I
I
R
L
A
E
A
F
K
Q
Y
N
V
V
P
E
V
E
V
Y
E
S
G
M
V
D
A
V
A
R
L
I
K
K
G
I
I
-
T
Q
N
P
L
H
I
Q
F
V
L
G
V
P
G
G
M
S
G
---
K
P
K
N
L
---
M
----
Y
M
M
E
----
H
L
K
E
E
IP
T
A
T
W
A
V
A
G
I
G
R
W
H
I
P
T
S
L
I
A
M
V
T
G
G
H
I
R
C
G
F
E
D
N
I
F
Y
H
K
G
V
I
A
E
S
N
A
Q
L
V
A
R
L
A
R
I
A
K
E
I
G
R
P
L
A
T
P
E
Q
A
R
E
I
L
A
L
N
-
23
PsiBlast_CBE
77.66
39%
-33
- C5 -
-
2Y7F
1
KCE_CLOAI
C:
[8-280]
-
E
P
L
I
L
T
A
A
I
T
G
A
E
T
T
R
A
D
Q
P
N
L
P
I
T
P
E
E
Q
A
K
E
A
K
A
C
F
E
A
G
A
R
V
I
H
L
H
I
R
E
-
D
D
-
G
R
P
S
Q
R
L
D
R
F
Q
E
A
I
S
A
I
R
E
-
V
-
V
P
E
I
I
I
Q
I
S
T
G
-
G
-----
A
V
G
--------------
E
S
F
D
K
R
L
--------------
A
P
L
A
-
L
-
K
P
E
M
A
T
L
N
A
G
T
L
N
F
--
G
D
------------------------
D
I
F
I
--
N
H
P
A
D
I
I
R
L
A
E
A
F
K
Q
Y
N
V
V
P
E
V
E
V
Y
E
S
G
M
V
D
A
V
A
R
L
I
K
K
G
I
I
T
Q
-
N
P
L
H
I
Q
F
V
L
G
V
P
G
G
M
S
G
---
K
P
K
N
L
---
M
YMME
H
L
K
E
----
E
I
P
T
---
A
T
-
W
A
V
A
G
I
G
R
W
H
I
P
T
S
L
I
A
M
V
T
G
G
H
I
R
C
G
F
E
D
N
I
F
Y
H
K
G
V
I
A
E
S
N
A
Q
L
V
A
R
L
A
R
I
A
K
E
I
G
R
P
L
A
T
P
E
Q
A
R
E
I
L
A
L
--
26
PsiBlast_CBE
77.52
39%
-35
- C5 -
-
2Y7D
1
KCE_CLOAI
D:
[8-280]
-
E
P
L
I
L
T
A
A
I
T
G
A
E
T
T
R
A
D
Q
P
N
L
P
I
T
P
E
E
Q
A
K
E
A
K
A
C
F
E
A
G
A
R
V
I
H
L
H
I
R
E
-
D
D
-
G
R
P
S
Q
R
L
D
R
F
Q
E
A
I
S
A
I
R
E
-
V
-
V
P
E
I
I
I
Q
I
S
T
G
-
G
-----
A
V
G
--------------
E
S
F
D
K
R
L
--------------
A
P
L
A
-
L
-
K
P
E
M
A
T
L
N
A
G
T
L
N
F
--
G
D
------------------------
D
I
F
I
--
N
H
P
A
D
I
I
R
L
A
E
A
F
K
Q
Y
N
V
V
P
E
V
E
V
Y
E
S
G
M
V
D
A
V
A
R
L
I
K
K
G
I
I
T
Q
-
N
P
L
H
I
Q
F
V
L
G
V
P
G
G
M
S
G
---
K
P
K
N
L
---
M
Y
M
M
E
H
L
K
E
----
E
I
P
T
---
A
T
-
W
A
V
A
G
I
G
R
W
H
I
P
T
S
L
I
A
M
V
T
G
G
H
I
R
C
G
F
E
D
N
I
F
Y
H
K
G
V
I
A
E
S
N
A
Q
L
V
A
R
L
A
R
I
A
K
E
I
G
R
P
L
A
T
P
E
Q
A
R
E
I
L
A
L
--
28
PsiBlast_CBE
77.41
39%
-34
- C5 -
-
2Y7D
1
KCE_CLOAI
B:
[8-280]
-
E
P
L
I
L
T
A
A
I
T
G
A
E
T
T
R
A
D
Q
P
N
L
P
I
T
P
E
E
Q
A
K
E
A
K
A
C
F
E
A
G
A
R
V
I
H
L
H
I
R
E
-
D
D
-
G
R
P
S
Q
R
L
D
R
F
Q
E
A
I
S
A
I
R
E
-
V
-
V
P
E
I
I
I
Q
I
S
T
G
-
G
-----
A
V
G
--------------
E
S
F
D
K
R
L
--------------
A
P
L
A
-
L
-
K
P
E
M
A
T
L
N
A
G
T
L
N
F
--
G
D
------------------------
D
I
F
I
--
N
H
P
A
D
I
I
R
L
A
E
A
F
K
Q
Y
N
V
V
P
E
V
E
V
Y
E
S
G
M
V
D
A
V
A
R
L
I
K
K
G
I
I
T
Q
-
N
P
L
H
I
Q
F
V
L
G
V
P
G
G
M
S
G
---
K
P
K
N
L
---
M
Y
M
M
E
H
L
K
E
----
E
I
P
T
---
A
T
-
W
A
V
A
G
I
G
R
W
H
I
P
T
S
L
I
A
M
V
T
G
G
H
I
R
C
G
F
E
D
N
I
F
Y
H
K
G
V
I
A
E
S
N
A
Q
L
V
A
R
L
A
R
I
A
K
E
I
G
R
P
L
A
T
P
E
Q
A
R
E
I
L
A
L
--
6
PsiBlast_PDB
77.34
36%
-26
- C5 -
-
3C6C
4
?
A:
[23-312]
--
K
V
I
L
T
C
A
V
T
G
N
A
P
F
N
P
K
H
P
S
M
P
I
T
P
A
Q
I
A
D
A
C
V
E
A
A
K
A
G
A
S
V
A
H
I
H
V
R
D
P
K
T
-
G
G
G
S
R
D
P
V
L
F
K
E
V
V
D
R
V
R
S
-
S
G
T
-
D
I
V
L
N
L
T
C
G
-
L
G
A
--
F
L
L
P
--------------
D
P
E
D
E
S
K
ALPE
S
D
V
V
P
V
A
E
R
V
K
H
L
E
D
C
-
L
P
E
I
A
S
L
D
I
T
T
G
N
Q
V
E
G
K
------------------------
L
E
F
V
Y
L
N
T
T
R
T
L
R
A
M
A
R
R
F
Q
E
L
G
I
K
P
E
L
E
V
F
S
P
G
D
I
L
F
G
K
Q
L
I
E
E
G
L
I
-
D
-
G
V
P
L
F
Q
M
V
L
G
V
L
W
G
A
P
A
---
S
T
E
T
M
---
I
----
Y
Q
R
N
----
L
I
P
A
---
N
A
Q
W
A
A
F
G
I
G
R
D
Q
M
P
M
M
A
Q
A
A
L
L
G
G
N
V
R
V
G
L
E
D
N
L
Y
L
S
R
G
V
F
A
T
-
N
G
Q
L
V
E
R
A
R
T
V
I
E
H
L
G
M
S
V
A
T
P
D
E
A
R
D
I
M
G
L
--
8
PsiBlast_PDB
77.22
32%
-39
- C5 -
-
3NO5
3
?
A:
[7-274]
----
I
I
S
V
A
I
T
G
S
L
P
R
K
K
D
N
P
A
V
P
I
T
V
S
E
Q
V
E
S
T
Q
A
A
F
E
A
G
A
T
L
V
H
L
H
V
R
N
-
D
D
-
E
T
P
T
S
N
P
D
R
F
A
L
V
L
E
G
I
R
K
-
H
-
A
P
G
M
I
T
Q
V
S
T
G
-
G
R
S
--------------------
G
A
G
N
E
R
G
--------------
A
M
L
S
-
L
-
R
P
D
M
A
S
L
A
T
G
S
V
N
F
--
P
T
------------------------
R
V
Y
D
--
N
P
P
E
L
V
D
W
L
A
A
E
M
K
T
Y
G
I
K
P
E
V
E
A
F
D
L
S
M
I
F
Q
A
A
A
M
Q
A
A
G
A
I
-
V
-
G
P
L
H
I
Q
F
V
M
G
I
K
N
A
M
P
V
---
D
R
E
V
L
E
F
Y
V
----
Q
T
L
K
----
R
L
S
P
---
D
A
T
W
T
G
A
G
I
G
R
H
Q
L
T
M
A
R
W
S
L
E
L
G
G
H
C
R
T
G
L
E
D
N
V
R
L
D
K
N
T
L
A
P
S
N
A
A
L
V
R
Q
V
A
E
L
C
E
E
Y
G
R
P
V
A
T
A
A
Q
A
R
E
I
M
S
L
--
21
PsiBlast_CBE
77.05
39%
-34
- C5 -
-
2Y7G
1
KCE_CLOAI
B:
[8-280]
-
E
P
L
I
L
T
A
A
I
T
G
A
E
T
T
R
A
D
Q
P
N
L
P
I
T
P
E
E
Q
A
K
E
A
K
A
C
F
E
A
G
A
R
V
I
H
L
H
I
R
E
-
D
D
-
G
R
P
S
Q
R
L
D
R
F
Q
E
A
I
S
A
I
R
E
-
V
-
V
P
E
I
I
I
Q
I
S
T
G
-
G
-----
A
V
G
--------------
E
S
F
D
K
R
L
--------------
A
P
L
A
-
L
-
K
P
E
M
A
T
L
N
A
G
T
L
N
F
--
G
D
------------------------
D
I
F
I
--
N
H
P
A
D
I
I
R
L
A
E
A
F
K
Q
Y
N
V
V
P
E
V
E
V
Y
E
S
G
M
V
D
A
V
A
R
L
I
K
K
G
I
I
T
Q
-
N
P
L
H
I
Q
F
V
L
G
V
P
G
G
M
S
G
---
K
P
K
N
L
---
M
YMME
H
L
K
E
----
E
I
P
T
---
A
T
-
W
A
V
A
G
I
G
R
W
H
I
P
T
S
L
I
A
M
V
T
G
G
H
I
R
C
G
F
E
D
N
I
F
Y
H
K
G
V
I
A
E
S
N
A
Q
L
V
A
R
L
A
R
I
A
K
E
I
G
R
P
L
A
T
P
E
Q
A
R
E
I
L
A
L
--
3
PsiBlast_PDB
77.04
39%
-35
- C5 -
-
2Y7F
1
KCE_CLOAI
A:
[8-280]
-
E
P
L
I
L
T
A
A
I
T
G
A
E
T
T
R
A
D
Q
P
N
L
P
I
T
P
E
E
Q
A
K
E
A
K
A
C
F
E
A
G
A
R
V
I
H
L
H
I
R
E
-
D
D
-
G
R
P
S
Q
R
L
D
R
F
Q
E
A
I
S
A
I
R
E
-
V
-
V
P
E
I
I
I
Q
I
S
T
G
-
G
-----
A
V
G
--------------
E
S
F
D
K
R
L
--------------
A
P
L
A
-
L
-
K
P
E
M
A
T
L
N
A
G
T
L
N
F
--
G
D
------------------------
D
I
F
I
--
N
H
P
A
D
I
I
R
L
A
E
A
F
K
Q
Y
N
V
V
P
E
V
E
V
Y
E
S
G
M
V
D
A
V
A
R
L
I
K
K
G
I
I
T
Q
-
N
P
L
H
I
Q
F
V
L
G
V
P
G
G
M
S
G
---
K
P
K
N
L
---
M
Y
M
M
E
H
L
K
E
----
E
I
P
T
---
A
T
-
W
A
V
A
G
I
G
R
W
H
I
P
T
S
L
I
A
M
V
T
G
G
H
I
R
C
G
F
E
D
N
I
F
Y
H
K
G
V
I
A
E
S
N
A
Q
L
V
A
R
L
A
R
I
A
K
E
I
G
R
P
L
A
T
P
E
Q
A
R
E
I
L
A
L
--
4
PsiBlast_PDB
76.96
39%
-33
- C5 -
-
2Y7G
2
KCE_CLOAI
A:
[8-280]
-
E
P
L
I
L
T
A
A
I
T
G
A
E
T
T
R
A
D
Q
P
N
L
P
I
T
P
E
E
Q
A
K
E
A
K
A
C
F
E
A
G
A
R
V
I
H
L
H
I
R
E
-
D
D
-
G
R
P
S
Q
R
L
D
R
F
Q
E
A
I
S
A
I
R
E
-
V
-
V
P
E
I
I
I
Q
I
S
T
G
-
G
-----
A
V
G
--------------
E
S
F
D
K
R
L
--------------
A
P
L
A
-
L
-
K
P
E
M
A
T
L
N
A
G
T
L
N
F
--
G
D
------------------------
D
I
F
I
--
N
H
P
A
D
I
I
R
L
A
E
A
F
K
Q
Y
N
V
V
P
E
V
E
V
Y
E
S
G
M
V
D
A
V
A
R
L
I
K
K
G
I
I
T
Q
-
N
P
L
H
I
Q
F
V
L
G
V
P
G
G
M
S
G
---
K
P
K
N
L
---
M
Y
M
M
E
H
L
K
E
----
E
I
P
T
---
A
T
-
W
A
V
A
G
I
G
R
W
H
I
P
T
S
L
I
A
M
V
T
G
G
H
I
R
C
G
F
E
D
N
I
F
Y
H
K
G
V
I
A
E
S
N
A
Q
L
V
A
R
L
A
R
I
A
K
E
I
G
R
P
L
A
T
P
E
Q
A
R
E
I
L
A
L
--
35
HHSearch
76.90
38%
-15
* C5 *
-
3C6C
4
?
A:
[21-314]
S
R
K
V
I
L
T
C
A
V
T
G
N
A
P
F
N
P
K
H
P
S
M
P
I
T
P
A
Q
I
A
D
A
C
V
E
A
A
K
A
G
A
S
V
A
H
I
H
V
R
D
-
P
K
T
G
G
G
S
R
D
P
V
L
F
K
E
V
V
D
R
V
R
S
S
G
-
T
-
D
I
V
L
N
L
T
C
G
L
G
A
F
--
L
L
P
D
PEDESKALPE
S
D
V
V
P
V
-
A
E
R
V
--------------
K
H
L
E
-
D
C
L
P
E
I
A
S
L
D
I
T
T
G
N
Q
--
V
E
GK
L
E
--------------------
F
V
Y
L
--
N
T
T
R
T
L
R
A
M
A
R
R
F
Q
E
L
G
I
K
P
E
L
E
V
F
S
P
G
D
I
L
F
G
K
Q
L
I
E
E
G
L
I
-
D
-
G
V
P
L
F
Q
M
V
L
G
V
L
W
G
A
P
A
---
S
T
E
T
M
---
I
----
Y
Q
R
N
----
L
I
P
A
---
N
A
Q
W
A
A
F
G
I
G
R
D
Q
M
P
M
M
A
Q
A
A
L
L
G
G
N
V
R
V
G
L
E
D
N
L
Y
L
S
R
G
V
F
A
-
T
N
G
Q
L
V
E
R
A
R
T
V
I
E
H
L
G
M
S
V
A
T
P
D
E
A
R
D
I
M
G
L
S
R
25
PsiBlast_CBE
76.90
39%
-32
- C5 -
-
2Y7E
1
KCE_CLOAI
B:
[8-280]
-
E
P
L
I
L
T
A
A
I
T
G
A
E
T
T
R
A
D
Q
P
N
L
P
I
T
P
E
E
Q
A
K
E
A
K
A
C
F
E
A
G
A
R
V
I
H
L
H
I
R
E
-
D
D
-
G
R
P
S
Q
R
L
D
R
F
Q
E
A
I
S
A
I
R
E
-
V
-
V
P
E
I
I
I
Q
I
S
T
G
-
G
-----
A
V
G
--------------
E
S
F
D
K
R
L
--------------
A
P
L
A
-
L
-
K
P
E
M
A
T
L
N
A
G
T
L
N
F
--
G
D
------------------------
D
I
F
I
--
N
H
P
A
D
I
I
R
L
A
E
A
F
K
Q
Y
N
V
V
P
E
V
E
V
Y
E
S
G
M
V
D
A
V
A
R
L
I
K
K
G
I
I
T
Q
-
N
P
L
H
I
Q
F
V
L
G
V
P
G
G
M
S
G
---
K
P
K
N
L
---
M
Y
M
M
E
H
L
K
E
----
E
I
P
T
---
A
T
-
W
A
V
A
G
I
G
R
W
H
I
P
T
S
L
I
A
M
V
T
G
G
H
I
R
C
G
F
E
D
N
I
F
Y
H
K
G
V
I
A
E
S
N
A
Q
L
V
A
R
L
A
R
I
A
K
E
I
G
R
P
L
A
T
P
E
Q
A
R
E
I
L
A
L
--
34
HHSearch
76.73
33%
-34
- C5 -
-
3LOT
1
?
D:
[5-308]
D
D
V
V
I
V
T
C
A
I
T
G
A
I
H
T
P
S
M
S
P
Y
L
P
V
T
P
D
Q
I
V
E
E
A
V
K
A
A
E
A
G
A
G
M
V
H
I
H
A
R
D
-
P
K
D
G
R
P
T
T
D
V
E
V
F
R
Y
I
C
R
E
I
K
K
-
Q
-
S
-
D
V
V
I
N
V
T
T
G
-
G
G
G
TL
G
I
P
----------------
V
-
E
E
R
A
--------------
K
V
V
P
-
A
L
K
P
E
I
A
T
F
N
M
G
S
M
N
F
--
A
I
HPLLKKYKEFKYDWEPEYLEMTRD
I
V
F
R
--
N
T
F
K
D
L
E
A
L
S
R
I
F
K
E
N
D
T
K
P
E
L
E
C
Y
D
I
G
Q
I
Y
N
T
A
F
M
F
H
E
G
Y
L
-
E
-
P
P
L
R
L
Q
F
I
H
G
I
L
G
G
I
G
T
---
A
V
E
D
V
---
L
----
F
M
K
Q
TADR
L
I
G
R
E--
N
Y
T
W
S
L
V
G
A
G
R
F
Q
M
P
L
G
T
L
A
V
I
M
G
G
D
V
R
V
G
L
E
D
S
L
Y
I
E
R
G
K
L
A
K
S
N
A
E
Q
V
E
K
M
V
R
I
V
K
E
L
G
K
R
P
A
T
P
D
E
V
R
E
I
L
G
L
K
G
30
HHSearch
76.64
34%
-22
- C5 -
-
3NO5
1
?
E:
[3-275]
N
K
P
C
I
I
S
V
A
I
T
G
S
L
P
R
K
K
D
N
P
A
V
P
I
T
V
S
E
Q
V
E
S
T
Q
A
A
F
E
A
G
A
T
L
V
H
L
H
V
R
N
-
D
D
-
E
T
P
T
S
N
P
D
R
F
A
L
V
L
E
G
I
R
K
-
H
-
A
P
G
M
I
T
Q
V
S
T
G
-
G
R
S
--
G
A
G
------------------
N
E
R
G
--------------
A
M
L
S
-
L
-
R
P
D
M
A
S
L
A
T
G
S
V
N
F
--
P
T
------------------------
R
V
Y
D
--
N
P
P
E
L
V
D
W
L
A
A
E
M
K
T
Y
G
I
K
P
E
V
E
A
F
D
L
S
M
I
F
Q
A
A
A
M
Q
A
A
G
A
I
-
V
-
G
P
L
H
I
Q
F
V
M
G
I
K
N
A
M
P
V
---
D
R
E
V
L
---
E
----
F
Y
V
Q
TLKR
L
S
P
----
D
A
T
W
T
G
A
G
I
G
R
H
Q
L
T
M
A
R
W
S
L
E
L
G
G
H
C
R
T
G
L
E
D
N
V
R
L
D
K
N
T
L
A
P
S
N
A
A
L
V
R
Q
V
A
E
L
C
E
E
Y
G
R
P
V
A
T
A
A
Q
A
R
E
I
M
S
L
G
-
32
HHSearch
76.58
40%
-29
- C5 -
-
2Y7E
1
KCE_CLOAI
A:
[8-280]
-
E
P
L
I
L
T
A
A
I
T
G
A
E
T
T
R
A
D
Q
P
N
L
P
I
T
P
E
E
Q
A
K
E
A
K
A
C
F
E
A
G
A
R
V
I
H
L
H
I
R
E
-
D
D
-
G
R
P
S
Q
R
L
D
R
F
Q
E
A
I
S
A
I
R
E
-
V
-
V
P
E
I
I
I
Q
I
S
T
G
-
G
A
V
--
G
E
S
----------------
F
-
D
K
R
L
--------------
A
P
L
A
-
L
-
K
P
E
M
A
T
L
N
A
G
T
L
N
F
--
G
D
------------------------
D
I
F
I
--
N
H
P
A
D
I
I
R
L
A
E
A
F
K
Q
Y
N
V
V
P
E
V
E
V
Y
E
S
G
M
V
D
A
V
A
R
L
I
K
K
G
I
I
-
T
Q
N
P
L
H
I
Q
F
V
L
G
V
P
G
G
M
S
G
---
K
P
K
N
L
---
M
----
Y
M
M
E
----
H
L
K
E
E
IP
T
A
T
W
A
V
A
G
I
G
R
W
H
I
P
T
S
L
I
A
M
V
T
G
G
H
I
R
C
G
F
E
D
N
I
F
Y
H
K
G
V
I
A
E
S
N
A
Q
L
V
A
R
L
A
R
I
A
K
E
I
G
R
P
L
A
T
P
E
Q
A
R
E
I
L
A
L
--
9
PsiBlast_PDB
76.57
34%
-36
- C5 -
-
3FA5
3
?
A:
[10-279]
---
C
I
I
C
V
A
I
T
G
S
L
P
T
K
E
N
N
P
A
V
P
I
T
L
A
E
Q
V
E
S
T
H
E
A
F
E
A
G
A
S
I
A
H
C
H
V
R
D
-
D
E
-
G
R
P
T
S
D
P
D
R
F
A
A
L
K
E
G
L
E
R
-
H
-
C
P
G
M
I
V
Q
L
S
T
G
-
G
R
S
--------------------
G
A
G
Q
A
R
G
--------------
A
M
L
P
-
L
-
C
P
D
M
A
S
L
S
V
G
S
N
N
F
--
P
T
------------------------
R
V
Y
E
--
N
P
P
D
L
V
D
W
L
A
A
E
M
L
K
Y
D
I
K
P
E
I
E
A
F
D
L
S
H
I
L
Q
A
K
R
M
A
G
D
G
R
L
-
A
-
G
T
P
Y
V
Q
F
V
M
G
V
R
N
A
M
P
A
D
R
D
V
F
D
Y
Y
---
I
----
H
T
V
R
----
R
L
F
G
E--
D
A
P
W
C
A
A
G
I
G
P
S
Q
I
V
L
N
E
W
A
I
S
S
G
G
H
A
R
T
G
L
E
D
N
V
R
L
D
R
D
R
L
A
P
S
N
A
A
L
V
G
R
A
V
E
L
C
E
K
Y
E
R
P
V
A
T
W
R
Q
A
R
Q
I
L
G
L
--
24
PsiBlast_CBE
76.50
39%
-32
- C5 -
-
2Y7F
1
KCE_CLOAI
B:
[8-280]
-
E
P
L
I
L
T
A
A
I
T
G
A
E
T
T
R
A
D
Q
P
N
L
P
I
T
P
E
E
Q
A
K
E
A
K
A
C
F
E
A
G
A
R
V
I
H
L
H
I
R
E
-
D
D
-
G
R
P
S
Q
R
L
D
R
F
Q
E
A
I
S
A
I
R
E
-
V
-
V
P
E
I
I
I
Q
I
S
T
G
-
G
-----
A
V
G
--------------
E
S
F
D
K
R
L
--------------
A
P
L
A
-
L
-
K
P
E
M
A
T
L
N
A
G
T
L
N
F
--
G
D
------------------------
D
I
F
I
--
N
H
P
A
D
I
I
R
L
A
E
A
F
K
Q
Y
N
V
V
P
E
V
E
V
Y
E
S
G
M
V
D
A
V
A
R
L
I
K
K
G
I
I
T
Q
-
N
P
L
H
I
Q
F
V
L
G
V
P
G
G
M
S
G
---
K
P
K
N
L
---
M
Y
M
M
E
H
L
K
E
----
E
I
P
T
---
A
T
-
W
A
V
A
G
I
G
R
W
H
I
P
T
S
L
I
A
M
V
T
G
G
H
I
R
C
G
F
E
D
N
I
F
Y
H
K
G
V
I
A
E
S
N
A
Q
L
V
A
R
L
A
R
I
A
K
E
I
G
R
P
L
A
T
P
E
Q
A
R
E
I
L
A
L
--
22
PsiBlast_CBE
76.29
39%
-32
- C5 -
-
2Y7F
1
KCE_CLOAI
D:
[8-280]
-
E
P
L
I
L
T
A
A
I
T
G
A
E
T
T
R
A
D
Q
P
N
L
P
I
T
P
E
E
Q
A
K
E
A
K
A
C
F
E
A
G
A
R
V
I
H
L
H
I
R
E
-
D
D
-
G
R
P
S
Q
R
L
D
R
F
Q
E
A
I
S
A
I
R
E
-
V
-
V
P
E
I
I
I
Q
I
S
T
G
-
G
-----
A
V
G
--------------
E
S
F
D
K
R
L
--------------
A
P
L
A
-
L
-
K
P
E
M
A
T
L
N
A
G
T
L
N
F
--
G
D
------------------------
D
I
F
I
--
N
H
P
A
D
I
I
R
L
A
E
A
F
K
Q
Y
N
V
V
P
E
V
E
V
Y
E
S
G
M
V
D
A
V
A
R
L
I
K
K
G
I
I
T
Q
-
N
P
L
H
I
Q
F
V
L
G
V
P
G
G
M
S
G
---
K
P
K
N
L
---
M
YMME
H
L
K
E
----
E
I
P
T
---
A
T
-
W
A
V
A
G
I
G
R
W
H
I
P
T
S
L
I
A
M
V
T
G
G
H
I
R
C
G
F
E
D
N
I
F
Y
H
K
G
V
I
A
E
S
N
A
Q
L
V
A
R
L
A
R
I
A
K
E
I
G
R
P
L
A
T
P
E
Q
A
R
E
I
L
A
L
--