@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLN6: (2017-11-03 )
MLSLKSLQCFVTLVKTKSFTRTAEELYLTQPTISKILQQLEEQLQVQLLVKPDHGRKRQIELTEIGERIYQHAGELLQAEQNIFLEIENYQQLKTGTLKLGVPPLGSQLLTTALFDFHRQWPDIELAFMEVGSRGIEQALLNNELDVGVLLQPFDEQTFNSIELCNYPLMVLLRRDATWATRKKINLEELQHQSFLMFPENFSLNSIILDACKQHGFYPTIACRTSQWHLLADMVLQRMGIALLPQYYTDMLDPTLFAAVPLEKPNIQWHLVMAWKKNLPVSPAVQAWLSIVRQHFQHIKP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100-..-.-.-....--110.......120........130.......140.......150..--.....160....-...170.....--..180-........190.......----200--..--.--...-...210..--.---..-..220--------........230.......240.......250--........260..-.....270.......280.......290....--...300
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLS
L
K
S
L
Q
C
F
V
T
L
V
KTKSFTR
T
A
E
E
LYLT
Q
P
T
I
S
K
I
L
Q
Q
L
E
E
QL
Q
V
Q
L
L
V
KPDHGR
K
R
Q
I
E
L
T
E
I
G
E
R
I
Y
Q
H
A
G
E
L
L
Q
AEQ
N
I
F
L
E
IE
N
Y
Q
Q
LKTG
T
L
K
L-G-VP-P-L-
G
S
Q
L
--
L
T
T
A
L
F
D
F
H
RQW-PD
I
E
L
A
F
M
E
V
G
S
R
G
I
E
Q
A
L
LNNEL
D
V
G
V
L
LQPF--DEQTFNSIELCN-Y
P
L
M
V
L
L
RRDA--TWAT--RKKI
N
L
E
E
L
Q
HQ
S
F
L
MFP----E----NF--
S
--
L
N
S
-
I
I
L
D
A
C
K
Q--H---GF-Y
P
T
I
---------
A
CRTS
Q
W
H
L
L
A
D
M
V
L
Q
RM
G
I
A
L
L
P
Q
Y
Y
T
D
M---L
D
P
T
L
F
A
AVPLEK-PN
I
Q
W
H
L
V
M
A
WKKNLPV
S
P
A
V
Q
A
W
L
S
I
V
R
Q
H
F
--
Q
HIKP
32
HHSearch
79.36
25%
-75
- C1 -
-
4X6G
4
?
A:
[7-303]
-
M
T
L
T
E
L
R
Y
I
V
T
L
A
Q
E
Q
H
F
G
R
A
A
E
R
C
H
V
S
Q
P
T
L
S
V
G
V
K
K
L
E
D
E
L
G
V
L
I
F
E
R
S
----
K
S
A
V
R
L
T
P
V
G
E
G
I
V
A
Q
A
Q
K
V
L
E
Q
A
Q
G
I
R
E
L
A
Q
A
G
K
N
Q
L
A
A
P
L
K
V
-
G
-
A
I
-
Y
-
T
I
G
P
Y
L
--
F
P
H
L
I
P
Q
L
H
R
V
A
-
P
Q
M
P
L
Y
I
E
E
N
F
T
H
I
L
R
D
K
L
R
T
G
E
L
D
A
I
I
I
A
L
P
F
--
Q
E
A
D
V
L
T
K
P
L
F
D
-
E
P
F
Y
V
L
M
P
A
D
H
--
P
W
T
A
--
K
A
S
I
D
S
E
L
L
N
D
K
S
L
L
L
L
G
----
E
----
G
H
--
D
--
F
R
D
-
Q
V
L
E
A
C
P
T
--
V
R
K
G
D
E
-
N
K
H
T
---------
T
V
E
S
S
S
L
E
T
I
R
H
M
V
A
S
G
L
G
V
S
V
L
P
F
S
A
V
D
S
H
H
-
Y
A
P
G
V
I
E
V
R
P
F
S
A
-
P
V
P
F
R
T
V
A
I
A
W
R
A
S
F
P
R
P
R
A
I
E
V
L
A
D
S
I
R
L
C
S
-------
1
PsiBlast_PDB
78.34
25%
-86
- C1 -
-
4X6G
4
?
A:
[7-300]
-
M
T
L
T
E
L
R
Y
I
V
T
L
A
Q
E
Q
H
F
G
R
A
A
E
R
C
H
V
S
Q
P
T
L
S
V
G
V
K
K
L
E
D
E
L
G
V
L
I
F
E
R
----
S
K
S
A
V
R
L
T
P
V
G
E
G
I
V
A
Q
A
Q
K
V
L
E
Q
A
Q
G
I
R
E
L
A
Q
A
G
K
N
Q
L
A
A
P
L
K
V
-
G
A
I
Y
-
T
-
I
-
G
P
Y
L
--
F
P
H
L
I
P
Q
L
H
R
V
A
-
P
Q
M
P
L
Y
I
E
E
N
F
T
H
I
L
R
D
K
L
R
T
G
E
L
D
A
I
I
I
A
L
P
F
--
Q
E
A
D
V
L
T
K
P
L
F
D
-
E
P
F
Y
V
L
M
P
A
D
H
--
P
W
T
A
--
K
A
S
I
D
S
E
L
L
N
D
K
S
L
L
L
L
G
----
E
----
G
H
--
D
--
F
R
D
-
Q
V
L
E
A
C
------------
P
T
V
R
K
GDENK
H
T
T
V
E
S
S
S
L
E
T
I
R
H
M
V
A
S
G
L
G
V
S
V
L
P
F
S
A
V
D
S
H
H
-
Y
A
P
G
V
I
E
V
R
P
F
S
A
-
P
V
P
F
R
T
V
A
I
A
W
R
A
S
F
P
R
P
R
A
I
E
V
L
A
D
S
I
R
----------
31
HHSearch
77.36
25%
-81
- C1 -
-
4X6G
2
?
E:
[7-305]
-
M
T
L
T
E
L
R
Y
I
V
T
L
A
Q
E
Q
H
F
G
R
A
A
E
R
C
H
V
S
Q
P
T
L
S
V
G
V
K
K
L
E
D
E
L
G
V
L
I
F
E
---------
V
R
L
T
P
V
G
E
G
I
V
A
Q
A
Q
K
V
L
E
Q
A
Q
G
I
R
E
L
A
Q
A
G
K
N
Q
L
A
A
P
L
K
V
-
G
-
A
I
-
Y
-
T
I
G
P
Y
L
--
F
P
H
L
I
P
Q
L
H
R
V
A
-
P
Q
M
P
L
Y
I
E
E
N
F
T
H
I
L
R
D
K
L
R
T
G
E
L
D
A
I
I
I
A
L
P
F
--
Q
E
A
D
V
L
T
K
P
L
F
D
-
E
P
F
Y
V
L
M
P
A
D
H
--
P
W
T
A
--
K
A
S
I
D
S
E
L
L
N
D
K
S
L
L
L
L
G
----
E
----
G
H
--
D
--
F
R
D
-
Q
V
L
E
A
C
P
T
--
V
R
K
G
D
E
-
N
K
H
T
---------
T
V
E
S
S
S
L
E
T
I
R
H
M
V
A
S
G
L
G
V
S
V
L
P
F
S
A
V
D
S
H
H-
Y
A
P
G
V
I
E
V
R
P
F
S
A
-
P
V
P
F
R
T
V
A
I
A
W
R
A
S
F
P
R
P
R
A
I
E
V
L
A
D
S
I
R
L
C
S
--
V
A
---
2
PsiBlast_PDB
73.04
25%
-67
- C1 -
-
3K1N
1
BENM_ACIAD
A:
[1-295]
-
M
E
L
R
H
L
R
Y
F
V
A
V
V
E
E
Q
S
F
T
K
A
A
D
K
L
C
I
A
Q
P
P
L
S
R
Q
I
Q
N
L
E
E
E
L
G
I
Q
L
L
E
R
----
G
S
R
P
V
K
T
T
P
E
G
H
F
F
Y
Q
Y
A
I
K
L
L
S
N
V
D
Q
M
V
S
M
T
K
R
I
A
S
V
E
K
-
T
I
R
I
-
G
-
F
----
V
-
G
S
L
L
FG
L
L
P
R
I
I
H
L
Y
R
Q
A
H
P
N
L
R
I
E
L
Y
E
M
G
T
K
A
Q
T
E
A
L
K
E
G
R
I
D
A
G
F
G
R
L
K
I
--
S
D
P
A
I
K
R
T
L
L
R
N
-
E
R
L
M
V
A
V
H
A
S
H
PL
N
Q
M
K
--
D
K
G
V
H
L
N
D
L
I
D
E
K
I
L
L
Y
P
----
S
SPKP
N
F
--
S
--
T
H
---
V
M
N
I
F
S
D
--
H
---
G
L
-
E
P
T
K
---------
I
N
E
V
R
E
V
Q
L
A
L
G
L
V
A
A
G
E
G
I
S
L
V
P
A
-
S
T
Q
S
---
I
Q
L
F
N
L
S
Y
V
P
L
L
D
-
P
D
A
I
T
P
I
Y
I
A
V
-
R
N
M
E
E
S
T
Y
I
Y
S
L
Y
E
T
I
R
Q
I
Y
--
A
Y
---
3
PsiBlast_PDB
71.63
24%
-51
- C1 -
-
3K1M
2
BENM_ACIAD
A:
[1-295]
-
M
E
L
R
H
L
R
Y
F
V
A
V
V
E
E
Q
S
F
T
K
A
A
D
K
L
C
I
A
Q
P
P
L
S
R
Q
I
Q
N
L
E
E
E
L
G
I
Q
L
L
E
R
----
G
S
R
P
V
K
T
T
P
E
G
H
F
F
Y
Q
Y
A
I
K
L
L
S
N
V
D
Q
M
V
S
M
T
K
R
I
A
S
V
E
K
-
T
I
R
I
-
G
F
V
G
-
S
-
L
-
L
F
G
L
--
L
P
R
I
I
H
L
Y
R
Q
A
H
-
P
N
L
R
I
E
L
Y
E
M
G
T
K
A
Q
T
E
A
L
K
E
G
R
I
D
A
G
F
G
R
L
K
I
--
S
D
P
A
I
K
H
T
L
L
R
N
-
E
R
L
M
V
A
V
H
A
S
H
PL
N
Q
M
K
--
D
K
G
V
H
L
N
D
L
I
D
E
K
I
L
L
Y
P
----
S
SPKP
N
F
--
S
--
T
H
---
V
M
N
I
F
S
D
--
H
---
G
L
-
E
P
T
K
---------
I
N
E
V
R
E
V
Q
L
A
L
G
L
V
A
A
G
E
G
I
S
L
V
P
A
-
S
T
Q
S
---
I
Q
L
F
N
L
S
Y
V
P
L
L
D
-
P
D
A
I
T
P
I
Y
I
A
V
-
R
N
M
E
E
S
T
Y
I
Y
S
L
Y
E
T
I
R
Q
I
Y
--
A
Y
---
21
HHSearch
69.61
22%
-67
- C1 -
-
3FXQ
6
TSAR_COMTE
A:
[1-296]
M
L
K
L
Q
T
L
Q
A
L
I
C
I
E
E
V
G
S
L
R
A
A
A
Q
L
L
H
L
S
Q
P
A
L
S
A
A
I
Q
Q
L
E
D
E
L
K
A
P
L
L
V
R
T
----
K
R
G
V
S
L
T
S
F
G
Q
A
F
M
K
H
A
R
L
I
V
T
E
S
R
R
A
Q
E
E
I
G
Q
L
R
G
R
W
E
G
H
I
T
F
-
A
-
A
S
-
P
-
A
I
A
L
A
A
--
L
P
L
A
L
A
S
F
A
R
E
F
-
P
D
V
T
V
N
V
R
D
G
M
Y
P
A
V
S
P
Q
L
R
D
G
T
L
D
F
A
L
T
A
A
H
K
HD
I
D
T
D
L
E
A
Q
P
L
Y
V
-
S
D
V
V
I
V
G
Q
R
Q
H
--
P
M
A
N
--
A
--
T
R
L
A
E
L
Q
E
C
R
W
A
F
S
S
----
A
----
P
R
--
G
--
P
G
A
-
I
I
R
N
A
F
A
R
--
Y
---
G
L
P
E
P
K
L
---------
G
L
V
C
E
S
F
L
A
L
P
G
V
V
A
H
S
D
L
L
T
T
M
P
R
T
L
Y
E
R
NA-
F
K
D
-
Q
L
C
S
I
P
L
Q
D
-
A
L
P
N
P
T
I
Y
V
L
R
R
H
D
L
P
V
T
P
A
A
A
G
L
I
R
W
I
Q
H
H
A
--
L
----
4
PsiBlast_PDB
65.84
25%
-59
- C- -
-
3K1P
-
BENM_ACIAD
A:
[1-295]
-
M
E
L
R
H
L
R
Y
F
V
A
V
V
E
E
Q
S
F
T
K
A
A
D
K
L
C
I
A
Q
P
P
L
S
R
Q
I
Q
N
L
E
E
E
L
G
I
Q
L
L
E
R
G
S
----
R
P
V
K
T
T
P
E
G
H
F
F
Y
Q
Y
A
I
K
L
L
S
N
V
D
Q
M
V
S
M
T
K
R
I
A
S
V
E
K
-
T
I
R
I
-
G
-
F
----
V
-
G
S
L
L
FG
L
L
P
R
I
I
H
L
Y
R
Q
A
H
P
N
L
R
I
E
L
Y
E
M
G
T
K
A
Q
T
E
A
L
K
E
G
R
I
D
A
G
F
G
R
L
K
I
--
S
D
P
A
I
K
R
T
L
L
R
N
-
E
R
L
M
V
A
V
H
A
S
H
P
L
N
Q
M
K
--
D
K
G
V
H
L
N
D
L
I
D
E
K
I
L
L
Y
P
----
S
SPKP
N
F
--
S
--
T
H
---
V
M
N
I
F
S
D
--
H
---
G
L
-
E
P
T
K
---------
I
N
E
V
R
K
V
Q
L
A
L
G
L
V
A
A
G
E
G
I
S
L
V
P
A
-
S
T
Q
S
---
I
Q
L
F
N
L
S
Y
V
P
L
L
D
-
P
D
A
I
T
P
I
Y
I
A
V
-
R
N
M
E
E
S
T
Y
I
Y
S
L
Y
E
T
I
R
Q
I
Y
--
A
Y
---
22
HHSearch
65.04
22%
-44
- C1 -
-
3FZV
-
?
D:
[4-300]
-
Y
T
L
R
Q
L
K
Y
F
V
T
T
V
E
C
---
A
E
A
S
R
K
L
Y
I
A
Q
P
S
I
S
T
A
V
--
L
E
E
S
F
-----------------
L
T
P
A
G
A
R
F
Y
R
K
A
Q
E
L
L
R
M
A
H
E
F
E
Q
-----
N
D
V
I
A
G
Q
I
D
I
-
G
-
C
F
-
E
-
T
V
A
P
L
Y
--
L
P
G
L
I
A
G
F
R
Q
A
Y
-
P
G
V
E
I
R
I
R
D
G
E
Q
Q
E
L
V
Q
G
L
T
S
G
R
F
D
L
A
F
L
Y
E
H
D
--
L
D
S
T
I
E
T
E
P
L
M
P
P
Q
R
P
H
A
L
L
P
E
G
H
--
R
F
A
G
--
Q
A
Q
V
S
L
R
D
L
C
L
E
P
M
I
L
L
D
----
V
----
Q
---
P
--
S
R
T
-
Y
F
V
S
L
F
E
E
--
L
---
G
L
-
T
P
N
I
---------
A
F
S
S
P
S
I
E
M
V
R
G
M
V
G
Q
G
F
G
F
S
L
L
V
T
R
P
H
S
E
CTY
D
G
K
-
K
V
V
M
V
D
L
A
E
-
P
V
S
T
S
G
L
A
A
A
W
L
K
R
A
Q
L
T
K
P
A
R
L
F
V
D
Y
C
R
E
Q
L
--
G
K
---
25
HHSearch
64.30
18%
-71
- C1 -
-
1IZ1
-
?
B:
[1-293]
-
M
E
F
R
Q
L
K
Y
F
I
A
V
A
E
A
G
N
M
A
A
A
A
K
R
L
H
V
S
Q
P
P
I
T
R
Q
M
Q
A
L
E
A
D
L
G
V
V
L
L
E
R
S
----
H
R
G
I
E
L
T
A
A
G
H
A
F
L
E
D
A
R
R
I
L
E
L
A
G
R
S
G
D
R
S
R
A
A
A
R
G
D
V
G
E
L
S
V
-
A
-
Y
F
-
G
-
T
P
I
Y
R
S
--
L
P
L
L
L
R
A
F
L
T
S
T
-
P
T
A
T
V
S
L
T
H
M
T
K
D
E
Q
V
E
G
L
L
A
G
T
I
H
V
G
F
S
R
F
F
P
--
R
H
P
G
I
E
I
V
N
I
A
Q
-
E
D
L
Y
L
A
V
H
R
S
Q
--
S
G
K
F
--
G
K
T
C
K
L
A
D
L
R
A
V
E
L
T
L
F
P
----
R
----
G
G
RP
S
--
F
A
D
-
E
V
I
G
L
F
K
H
--
A
---
G
I
-
E
P
R
I
---------
A
R
V
V
E
D
A
T
A
A
L
A
L
T
M
A
G
A
A
S
S
I
V
P
A
S
V
A
A
I
---
R
W
P
-
D
I
A
F
A
R
I
V
G
-
T
R
V
K
V
P
I
S
C
I
F
R
K
E
K
-
Q
P
P
I
L
A
R
F
V
E
H
V
R
R
S
A
--
K
----
29
HHSearch
63.24
18%
-
- C1 -
-
3SZP
-
?
A:
[1-290]
-
M
K
L
D
D
L
N
L
F
R
L
V
V
E
N
G
S
Y
T
S
T
S
K
K
T
M
I
P
V
A
T
I
T
R
R
I
Q
A
L
E
D
S
L
N
L
R
L
L
N
R
H
----
A
R
K
L
T
L
T
E
A
G
E
R
F
Y
K
D
C
S
P
L
L
E
R
L
A
S
M
T
E
E
I
T
D
E
C
R
G
A
S
G
R
I
R
I
-
S
-
A
P
-
S
-
N
L
T
K
R
M
--
M
M
P
M
F
N
A
F
M
E
K
Y
-
P
D
I
H
I
E
L
M
M
S
N
Q
---
A
D
D
L
D
P
T
E
W
D
V
I
F
R
V
G
P
Q
--
R
D
S
S
L
I
A
R
K
I
G
E
-
V
K
D
I
L
V
A
S
P
Q
Y
--
L
S
S
H
--
P
Q
P
T
H
A
E
E
L
H
Q
H
Q
L
L
K
G
Y
----
P
----
L
L
--
K
---
W
Q
-
L
T
N
S
Q
G
E
T
--
V
---
V
N
-
S
D
R
G
---------
R
F
Q
A
S
A
L
N
V
V
R
S
A
C
S
E
G
L
G
I
T
L
M
P
D
V
M
L
R
E
F
L
-
E
D
G
-
S
L
V
Q
V
L
S
D
W
-
S
S
N
P
R
D
I
Y
M
L
Y
N
H
K
D
H
Q
P
E
K
V
R
L
F
I
D
F
V
I
G
Y
H
--
L
----
30
HHSearch
61.63
21%
-55
- C1 -
-
3HHG
-
?
E:
[2-296]
K
T
N
S
E
E
L
T
V
F
V
Q
V
V
E
S
G
S
F
S
R
A
A
E
Q
L
A
M
A
N
S
A
V
S
R
I
V
K
R
L
E
E
K
L
G
V
N
L
L
N
R
T
----
T
R
Q
L
S
L
T
E
E
G
A
Q
Y
F
R
R
A
Q
R
I
L
Q
E
M
A
A
A
E
T
E
M
L
A
V
H
E
I
P
Q
G
V
L
S
V
-
D
-
S
A
-
M
-
P
M
V
L
H
L
--
L
A
P
L
A
A
K
F
N
E
R
Y
-
P
H
I
R
L
S
L
V
S
S
---
E
G
Y
I
N
L
I
E
R
K
V
D
I
A
L
R
A
G
E
L
--
D
D
S
G
L
R
A
R
H
L
F
D
-
S
R
F
R
V
I
A
S
P
E
Y
--
L
A
K
H
--
G
T
P
Q
S
T
E
E
L
A
G
H
Q
C
L
G
F
T
----
E
----
P
G
--
S
--
L
N
T
-
W
--
A
V
L
D
A
QG
N
---
P
Y
-
K
I
S
P
---------
H
F
T
A
S
S
G
E
I
L
R
S
L
C
L
S
G
C
G
I
V
C
L
S
D
F
L
V
D
N
DI-
A
E
G
-
K
L
I
P
L
L
A
E
Q
T
S
D
K
T
H
P
F
N
A
V
Y
Y
S
D
K
A
V
N
L
R
L
R
V
F
L
D
F
L
V
E
E
L
--
G
N
N
--
42
Fugue
61.10
17%
-67
- C1 -
-
1IZ1
-
?
A:
[1-292]
-
M
E
F
R
Q
L
K
Y
F
I
A
V
A
E
A
G
N
M
A
A
A
A
K
R
L
H
V
S
Q
P
P
I
T
R
Q
M
Q
A
L
E
A
D
L
G
V
V
L
L
E
R
S
H
R
G
----
I
E
L
T
A
A
G
H
A
F
L
E
D
A
R
R
I
L
E
L
A
G
R
S
G
D
R
S
R
A
A
A
R
G
D
V
G
E
L
S
V
-
A
-
Y
F
G
T
-
P
-
I
Y
R
S
--
L
P
L
L
L
R
A
F
L
T
S
T
-
P
T
A
T
V
S
L
T
H
M
T
K
D
E
Q
V
E
G
L
L
A
G
T
I
H
V
G
F
S
R
F
F
P
--
R
H
P
G
I
E
I
V
N
I
A
Q
-
E
D
L
Y
L
A
V
H
R
S
Q
--
S
G
K
F
--
G
K
T
C
K
L
A
D
L
R
A
V
E
L
T
L
F
P
----
R
----
G
G
--
R
PS
F
A
D
-
E
V
I
G
L
F
K
H
--
A
---
G
I
-
E
P
R
I
---------
A
R
V
V
E
D
A
T
A
A
L
A
L
T
M
A
G
A
A
S
S
I
V
P
A
S
V
A
A
I
---
R
W
P
D
-
I
A
F
A
R
I
V
G
-
T
R
V
K
V
P
I
S
C
I
F
R
K
E
-
K
Q
P
P
I
L
A
R
F
V
E
H
V
R
R
S
A
-------
7
PsiBlast_PDB
60.51
26%
-94
- C1 -
-
3HHG
-
?
A:
[8-245]
------
L
T
V
F
V
Q
V
V
E
S
G
S
F
S
R
A
A
E
Q
L
A
M
A
N
S
A
V
S
R
I
V
K
R
L
E
E
K
L
G
V
N
L
L
N
R
T
----
T
R
Q
L
S
L
T
E
E
G
A
Q
Y
F
R
R
A
Q
R
I
L
Q
E
M
A
A
A
E
T
E
M
L
A
V
H
E
I
P
Q
G
V
L
S
V
D
S
-
A
M
-
P
-
M
-
V
L
H
L
--
L
A
P
L
A
A
K
F
N
E
R
Y
-
P
H
I
R
L
S
L
--
V
S
S
E
G
Y
I
N
-
L
I
E
R
K
V
D
I
A
L
R
A
G
E
L
--
D
D
S
G
L
R
A
R
H
L
F
D
-
S
R
F
R
V
I
A
S
P
E
Y
--
L
A
K
H
--
G
T
P
Q
S
T
E
E
L
A
G
H
Q
C
L
G
F
T
----
E
----
P
G
--
S
--
L
N
T
W
A
V
L
D
A
-
Q
G
--
N
---
P
Y
-
K
I
S
P
---------
H
F
T
A
S
S
G
E
I
L
R
S
L
C
L
S
G
C
G
I
V
C
L
S
D
F
L
V
D
---------------------------------------------------------
28
HHSearch
57.79
18%
-
- C- -
-
3T1B
-
?
C:
[1-290]
-
M
K
L
D
D
L
N
L
F
R
L
V
V
E
N
G
S
Y
T
S
T
S
K
K
T
M
I
P
V
A
T
I
T
R
R
I
Q
A
L
E
D
S
L
N
L
R
L
L
N
R
H
----
A
R
K
L
T
L
T
E
A
G
E
R
F
Y
K
D
C
S
P
L
L
E
R
L
A
S
M
T
E
E
I
T
D
E
C
R
G
A
S
G
R
I
R
I
-
S
-
A
P
-
S
-
E
L
T
K
R
M
--
M
M
P
M
F
N
A
F
M
E
K
Y
-
P
D
I
H
I
E
L
M
M
S
N
----
A
D
D
L
D
P
T
E
W
D
V
I
F
R
V
G
P
Q
--
R
D
S
S
L
I
A
R
K
I
G
E
-
V
K
D
I
L
V
A
S
P
Q
Y
--
L
S
S
H
--
P
Q
P
T
H
A
E
E
L
H
Q
H
Q
L
L
K
G
Y
----
P
----
L
L
--
K
---
W
Q
-
L
T
N
S
Q
G
E
T
--
V
---
V
N
-
S
D
R
G
---------
R
F
Q
A
S
A
L
N
V
V
R
S
A
C
S
E
G
L
G
I
T
L
M
P
D
V
M
L
R
E
FL-
E
D
G
-
S
L
V
Q
V
L
S
D
W
-
S
S
N
P
R
D
I
Y
M
L
Y
N
H
K
D
H
Q
P
E
K
V
R
L
F
I
D
F
V
I
G
Y
H
--
L
----
18
PsiBlast_PDB
54.82
23%
-109
- C1 -
-
4XWS
-
?
A:
[93-294]
--------------------------------------------------------------------------------------------
L
K
V
G
A
I
Y
T
--------
I
-
G
P
Y
L
--
F
P
H
L
I
P
Q
L
H
R
V
A
-
P
Q
M
P
L
Y
I
E
E
N
F
T
H
I
L
R
D
K
L
R
T
G
E
L
D
A
I
I
I
A
L
P
F
--
Q
E
A
D
V
L
T
K
P
L
F
D
-
E
P
F
Y
V
L
M
P
A
D
H
--
P
W
T
A
--
K
A
S
I
D
S
E
L
L
N
D
K
S
L
L
L
L
G
----
E
----
G
H
--
D
--
F
R
D
-
Q
V
L
E
A
C
------------
P
T
V
RKGDENK
H
T
T
V
E
S
S
S
L
E
T
I
R
H
M
V
A
S
G
L
G
V
S
V
L
P
F
S
A
V
D
S
HH-
Y
A
P
G
V
I
E
V
R
P
F
S
A
-
P
V
P
F
R
T
V
A
I
A
W
R
A
S
F
P
R
P
R
A
I
E
V
L
A
D
S
I
R
----------
8
PsiBlast_PDB
52.90
24%
-33
- C1 -
-
2H98
-
CATM_ACIAD
A:
[89-300]
------------------------------------------------------------------------------------------
S
Q
----
T
L
R
I
-
G
Y
V
S
-
S
-
L
-
L
Y
G
L
--
L
P
E
I
I
Y
L
F
R
Q
Q
N
-
P
E
I
H
I
E
L
I
E
C
G
T
K
D
Q
I
N
A
L
K
Q
G
K
I
D
L
G
F
G
R
L
K
I
--
T
D
P
A
I
R
R
I
M
L
H
K
-
E
Q
L
K
L
A
I
H
K
H
H
HL
N
Q
F
A
--
A
T
G
V
H
L
S
Q
I
I
D
E
P
M
L
L
Y
P
VSQK
P
----
N
F
--
A
----
T
-
F
I
Q
S
L
F
T
E
--
L
---
G
L
-
V
P
S
K
---------
L
T
E
I
R
E
I
Q
L
A
L
G
L
V
A
A
G
E
G
V
C
I
V
P
A
S
A
M
D
I
---
G
V
K
N
L
L
-
Y
I
P
I
L
D
-
D
D
A
Y
S
P
I
S
L
A
V
-
R
N
M
D
H
S
N
Y
I
P
K
I
L
A
C
V
Q
E
V
F
A
T
H
H
I
R
P
40
HHSearch
49.68
21%
-43
- C1 -
-
3HFU
1
CYNR_ECOLI
B:
[28-231]
---------------------------------------------------------------------------------------------
T
R
G
S
L
R
I
-
A
-
V
T
-
P
-
T
F
T
S
Y
F
--
I
G
P
L
M
A
D
F
Y
A
R
Y
-
P
S
I
T
L
Q
L
Q
E
M
S
Q
E
K
I
E
D
M
L
C
R
D
E
L
D
V
G
I
A
F
A
P
V
--
H
S
P
E
L
E
A
I
P
L
L
T
-
E
S
L
A
L
V
V
A
Q
H
H
--
P
L
A
V
--
H
E
Q
V
A
L
S
R
L
H
D
E
K
L
V
L
L
S
----
A
----
E
F
--
A
--
T
R
E
-
Q
I
D
H
Y
C
E
K
--
A
---
G
L
-
H
P
Q
V
---------
V
I
E
A
N
S
I
S
A
V
L
E
L
I
R
R
T
S
L
S
T
L
L
P
A
A
I
A
T
Q
----
H
D
-
G
L
K
A
I
S
L
A
P
-
P
L
L
E
R
T
A
V
L
L
R
R
K
N
S
W
Q
T
A
A
A
K
A
F
L
H
M
A
L
D
K
C
--
A
V
---
33
HHSearch
48.42
22%
-19
- C1 -
-
2H98
-
CATM_ACIAD
A:
[89-295]
----------------------------------------------------------------------------------------------
S
Q
T
L
R
I
-
G
-
Y
V
-
S
-
S
L
L
Y
G
L
--
L
P
E
I
I
Y
L
F
R
Q
Q
N
-
P
E
I
H
I
E
L
I
E
C
G
T
K
D
Q
I
N
A
L
K
Q
G
K
I
D
L
G
F
G
R
L
K
I
--
T
D
P
A
I
R
R
I
M
L
H
K
-
E
Q
L
K
L
A
I
H
K
H
H
--
H
L
N
Q
FA
A
T
G
V
H
L
S
Q
I
I
D
E
P
M
L
L
Y
P
----
V
----
S
Q
KP
N
--
F
A
T
-
F
I
Q
S
L
F
T
E
--
L
---
G
L
-
V
P
S
K
---------
L
T
E
I
R
E
I
Q
L
A
L
G
L
V
A
A
G
E
G
V
C
I
V
P
A
S
A
M
D
I
---
G
V
K
-
N
L
L
Y
I
P
I
L
D
-
D
D
A
Y
S
P
I
S
L
A
V
R
N
M
D
-
H
S
N
Y
I
P
K
I
L
A
C
V
Q
E
V
F
--
A
T
---
39
HHSearch
48.10
21%
-53
- C1 -
-
2HXR
-
CYNR_ECOLI
A:
[92-291]
------------------------------------------------------------------------------------------------
S
L
R
I
-
A
-
V
T
-
P
-
T
F
T
S
Y
F
--
I
G
P
L
M
A
D
F
Y
A
R
Y
-
P
S
I
T
L
Q
L
Q
E
M
S
Q
E
K
I
E
D
M
L
C
R
D
E
L
D
V
G
I
A
F
A
P
V
--
H
S
P
E
L
E
A
I
P
L
L
T
-
E
S
L
A
L
V
V
A
Q
H
H
--
P
L
A
V
--
H
E
Q
V
A
L
S
R
L
H
D
E
K
L
V
L
L
S
----
A
----
E
F
--
A
--
T
R
E
-
Q
I
D
H
Y
C
E
K
--
A
---
G
L
-
H
P
Q
V
---------
V
I
E
A
N
S
I
S
A
V
L
E
L
I
R
R
T
S
L
S
T
L
L
P
A
A
I
A
T
Q
----
H
D
-
G
L
K
A
I
S
L
A
P
-
P
L
L
E
R
T
A
V
L
L
R
R
K
N
S
W
Q
T
A
A
A
K
A
F
L
H
M
A
L
D
K
C
--
A
----
10
PsiBlast_PDB
47.96
22%
-42
- C1 -
-
3HFU
-
CYNR_ECOLI
A:
[30-222]
-----------------------------------------------------------------------------------------------
G
S
L
R
I
-
A
-
V
T
-
P
T
F
-
T
S
Y
F
--
I
G
P
L
M
A
D
F
Y
A
R
Y
-
P
S
I
T
L
Q
L
Q
E
M
S
Q
E
K
I
E
D
M
L
C
R
D
E
L
D
V
G
I
A
F
A
P
V
--
H
S
P
E
L
E
A
I
P
L
L
T
-
E
S
L
A
L
V
V
A
Q
H
H
--
P
L
A
V
--
H
E
Q
V
A
L
S
R
L
H
D
E
K
L
V
L
L
S
----
A
----
E
F
--
A
--
T
R
E
-
Q
I
D
H
Y
C
E
K
--
A
---
G
L
-
H
P
Q
V
---------
V
I
E
A
N
S
I
S
A
V
L
E
L
I
R
R
T
S
L
S
T
L
L
P
A
A
I
A
T
Q
---
H
D
G
--
L
K
A
I
S
L
A
P
-
P
L
L
E
R
T
A
V
L
L
R
R
K
N
S
W
Q
T
A
A
A
K
A
F
L
--------------