@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLQ8: (2017-11-04 )
MTITPKPDSVVYRVRVAVPVHLYDTFDYTLTKAQYERAQVGSRVAISFGRQNLIGIITEKVDPQESFTGNFQLKAISELLDDEPILDEQVLNLLTWSAQYYQFPIGEVMQTALPALLRQGKPMDVLFHLWKIIPCDNAEALLKRSIKQQDAYQILKLHPAGTTENILNLSGVETATLKALQKKGLVDCTLEPHDFSPAPVQLAQMPLTLNEDQKKATQHVLNAQHQYQAFLLDGLTGSGKTEVYLHIMHEVLKQGKQVLVLVPEIGLTPQTISRFKSRFNCDIALLHSGLNDSKRLQAWQQAQTGKASIILGTRSAIYTPLPRLGLIILDEEHDLSYKQQEGFRYHARDVALYRGHLQGCPVLLGSATPSIDSYHLVETGKLTALQLNQRAGHALLPKMHLIDLKIVKKQHGISQPLIEQIKNTLARKEQVLIFLNRRGYAPVLVCESCGWQANCPHCDAHFTLHTQPYSYLHCHHCGTVHRLPDHCPECQQKSLKTLGAGTAKVEEHLQELFPDHDVIRVDRDSTSRVGSWQKIYDRIQQNKPSILLGTQMLAKGHHFPHVTLVAILDIDAGLLSVDIRAPERTAQLIVQVAGRAGRGEHKGHVYLQTLRPDHPLLTTLIEKDYRAVAKQTLAERKVALLPPYRYAVLIRAESKDRDYTLHFLNEAAEQLRQIAGGIVDIWGPIPAPMERKAGRYRAHMVILSADRTRLHFYLRQWWAQLVHAPRQHQLRLSIDVDPQEFS
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50-....--....60........70........80......---..--90.....-...100.......110.......120-..------.....130.--......140---........150--------------------------------........--.160.......170---------------------------.........180.......-190-------........200....-----------------------....210.----------------------------------------......220..---.....--230...---------------..----....240.......250--..------------.....260.......270.......280--.---.....-----...290.....-----------..300--.......310.....-----------------.--------.------------320--..--.....330.......340.......350.--...-...360......--.370.--......--380.......390...-.....400.-......410.......420..-.....430.......440.......450.......460...-...-.470.......--------480..--.....490.......500.......510........520.......530.......540.......550---.......560.......570...-.....580....-...590......------.600.......610---------------........620.--......630........640.......650....-...-660.--......670.--.--.....680..--.......690.......700.--...------...710....-----------------------------...720.-.....-.730..----.....740-------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTITPKPD
S
V
V
Y
R
V
R
V
A
V
P
V
H
L
Y
DTFDY
T
L
T
K
A
Q
Y
E
R
A
QVG
S
R
V
A
I
SFGRQ-N
L
I
G
--
I
ITEKVDPQESFTGN
F
Q
L
K
A
I
S
E
L
LDDEPI
L
D
---
E
Q
--
V
L
N
L
L
TW-SA
Q
Y
Y
QF
P
I
G
E
V
M
Q
T
A
L
P
A
L
L
RQGK
P
-
M
D
------
V
L
F
H
L
W
K
II--PCD
N
A
E
A
L
----
L
K
R
S
I
K
Q
Q
D
----------------------------------
A
Y
Q
I
L
K
LH--PAGTTE
N
I
L
NLS-----------------------------GV
E
T
A
T
L
K
A
L
Q
KKG
L
V
D
C
T-LE--------PHDFSPAP
V
-
Q
L
A
QM-----------------------PLTLN
E
D
Q
----------------------------------------
K
K
A
T
Q
H
V
L
N
A
Q
---
H
Q
Y
Q
A
--
F
--LLD---------------GL----TGSGK
T
E
V
Y
L
H
I
M
H
E
V
L
--KQ------------G
K
Q
V
L
V
LVPEIGL
T
P
Q
T
I
S
R
F
K
S
RFN----C---
D
I
A
L
L
-----HSGLN
D
S
K
R
L
Q
-----------
A
W
Q
QA--QTG
K
A
S
I
I
L
GTR
S
A
I
-----------------Y--------T------------PLP--R
L
--
G
L
I
I
L
DEEHDLS
Y
K
Q
QEG
F
R
YHA
R
D
V
A
L
Y
--RGH-LQGC
P
V
L
LGSAT--PSID
S
--
Y
H
L
VET--G
K
L
T
A
L
Q
LNQRA-GHA-LLP
K
M
H
L
I
D
-
L
K
I
V
K
K
QHGIS
Q
P
L
I
E
Q
I
K
N
T
-LARK
E
Q
V
L
I
F
LNRRGY
A
P
V
L
V
CESCGWQANCPHCDA
H
F
T
L
H-TQP-
Y
S
Y
L
H
C
HHCG
T
--------
V
HRLP--DH
C
P
E
C
Q
Q
K
S
L
K
T
LGA
G
T
A
K
V
E
E
H
L
Q
E
-LFPDH
D
V
I
R
VDRDSTSRVG
S
W
Q
K
I
Y
D
R
I
QQNKP
S
I
L
L
G
T
Q
M
---
L
AKGHHFP
H
V
T
L
V
A
I
L
DI-DA
G
L
-
L
S
V
D
IRA
P
E
R
T
A
-
Q
L
I
V
Q
V
AGRAGR------GEHK
G
H
V
Y
L
Q
TLR----------------PD
H
P
L
L
T
T
L
I
E
K
--
D
Y
R
A
V
A
K
-
Q
T
L
A
ER
K
V
A
LLPP
Y
R
Y
A
V
L
I
R
AESKD-RD
Y
-
T
L
H
F
--
L
N
E
A
A
E
Q
L
R
Q
--
I
--AG
G
I
V
D
--IW--GPIPAP
M
E
RKAGR
Y
R
A
H
M
V
I
L
--SAD------
R
T
R
L
H
F
Y
L
R
Q
-----------------------------
W
W
A
Q
L
VH-APRQ
H
-
Q
L
R
L
S
I
----DVDPQEFS-------------------------------------------------------------------------------------------
36
Fugue
84.74
45%
-17
- C2 -
-
4NL4
1
?
H:
[18-747]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
A
H
V
A
L
P
V
P
L
P
R
T
F
D
Y
L
L
P
E
G
M
--
A
V
K
A
G
C
R
V
R
V
P
F
G
K
Q
-
E
R
I
G
--
I
V
A
A
V
S
E
R
S
E
--
L
P
L
D
E
L
K
P
V
A
E
A
L
D
D
E
P
V
F
S
---
T
T
--
V
W
R
L
L
M
W
-
A
A
E
Y
Y
H
H
P
I
G
D
V
L
F
H
A
L
P
V
M
L
R
Q
G
K
P
-
A
S
------
A
T
-
P
L
W
Y
W
F
--
A
T
E
Q
G
Q
V
V
DLNG
L
K
R
S
R
K
Q
Q
Q
----------------------------------
A
L
A
A
L
R
Q
G
--
K
--
I
W
R
H
Q
V
G
E
L
-----------------------------
E
F
N
E
A
A
L
Q
A
L
R
G
K
G
L
A
E
L
A
-
C
E
--------
A
T
D
W
R
S
A
Y
--
S
V
A
G
E
-----------------------
R
L
R
L
N
T
E
Q
----------------------------------------
A
T
A
V
G
A
I
H
S
A
A
---
D
R
F
S
A
--
W
--
L
L
A
---------------
G
I
----
T
G
S
G
K
T
E
V
Y
L
S
V
L
E
N
V
L
--
A
Q
------------
G
R
Q
A
L
V
M
V
P
E
I
G
L
T
P
Q
T
I
A
R
F
R
Q
R
F
N
----
A
---
P
V
E
V
L
-----
H
S
G
L
N
D
S
E
R
L
S
-----------
A
W
L
K
A
--
K
N
G
E
A
A
I
V
I
G
T
R
S
S
L
-----------------
F
--------
T
------------
P
F
K
--
D
L
--
G
V
I
V
I
D
E
E
H
D
S
S
Y
K
Q
Q
E
G
W
R
Y
H
A
R
D
L
A
V
W
--
R
A
H
-
S
E
Q
I
P
I
I
L
G
S
A
T
--
P
A
L
E
T
--
L
H
N
V
R
Q
--
G
K
Y
R
Q
L
T
L
S
K
P
--------
A
Q
Q
H
V
L
D
-
L
K
G
Q
P
L
Q
A
G
L
S
P
A
L
I
S
R
M
R
Q
H
-
L
Q
A
D
N
Q
V
I
L
F
L
N
R
R
G
F
A
P
A
L
L
C
H
D
C
G
W
I
A
E
C
P
R
C
D
S
Y
Y
T
L
H
-
Q
A
Q
-
H
-
H
L
R
C
H
H
C
D
S
--------
Q
R
P
I
P
--
R
Q
C
P
S
C
G
S
T
H
L
V
P
V
G
I
G
T
E
Q
L
E
Q
A
L
A
P
-
L
F
P
E
V
P
I
S
R
I
D
R
H
L
A
A
-----------
V
H
R
G
G
A
R
I
L
I
G
T
Q
M
---
L
A
K
G
H
H
F
P
D
V
T
L
V
S
L
L
D
V
-
D
G
A
L
-
F
S
A
D
F
R
S
A
E
R
F
A
-
Q
L
Y
T
Q
V
S
G
R
A
G
R
------
A
G
K
Q
G
E
V
I
L
Q
T
H
H
----------------
P
E
H
P
L
L
Q
T
L
L
Y
K
--
G
Y
D
A
F
A
E
-
Q
A
L
A
E
R
Q
T
M
Q
L
P
P
W
T
S
H
V
L
I
R
A
E
D
H
N
-
N
Q
Q
-
A
P
L
F
--
L
Q
Q
L
R
N
L
L
Q
A
SP
L
--
A
D
E
K
L
W
--
V
L
--
G
P
V
P
A
L
--------
R
W
Q
I
L
L
Q
--
H
P
S
------
R
V
R
L
Q
H
I
V
S
G
-----------------------------
T
L
A
L
I
N
T
-
L
P
E
A
W
-----
V
L
----
D
V
D
P
I
E
G
--------------------------------------------------------------------------------------------
1
PsiBlast_PDB
76.65
44%
-112
- C2 -
-
4NL8
-
?
A:
[22-746]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
P
V
P
L
P
R
T
F
D
Y
L
L
P
E
----
K
A
--
G
C
R
V
R
V
P
F
G
K
Q
-
E
R
I
G
--
I
V
A
A
V
------------
L
K
P
V
---
L
D
D
E
P
V
F
S
---
T
T
--
V
W
R
L
L
M
W
-
A
A
E
Y
Y
H
H
P
I
G
D
V
L
F
H
A
L
P
V
M
L
R
Q
G
K
P
-
A
S
------
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
N
T
E
Q
----------------------------------------
A
T
A
V
G
A
I
H
S
A
A
---
D
R
F
S
A
--
W
--
L
L
A
---------------
G
I
----
T
G
S
G
K
T
E
V
Y
L
S
V
L
E
N
V
L
--
A
Q
------------
G
R
Q
A
L
V
M
V
P
E
I
G
L
T
P
Q
T
I
A
R
F
R
Q
R
F
N
----
A
---
P
V
E
V
L
-----
H
S
G
L
N
D
S
E
R
L
S
-----------
A
W
L
K
A
--
K
N
G
E
A
A
I
V
I
G
T
R
S
S
L
-----------------
F
--------
T
------------
P
F
K
--
D
L
--
G
V
I
V
I
D
E
E
H
D
S
S
Y
K
Q
Q
E
G
W
R
Y
H
A
R
D
L
A
V
W
--
R
A
H
-
S
E
Q
I
P
I
I
L
G
S
A
T
--
P
A
L
E
T
--
L
H
N
V
R
Q
--
G
K
Y
R
Q
L
T
L
S
-----------
Q
Q
H
V
L
D
-
L
K
G
Q
P
L
Q
A
G
L
S
P
A
L
I
S
R
M
R
Q
H
-
L
Q
A
D
N
Q
V
I
L
F
L
N
R
R
G
F
A
P
A
L
L
C
H
D
C
G
W
I
A
E
C
P
R
C
D
S
Y
Y
T
L
H
--
Q
A
-
Q
H
H
L
R
C
H
H
C
D
S
--------
Q
R
P
I
P
--
R
Q
C
P
S
C
G
S
T
H
L
V
P
V
G
I
G
T
E
Q
L
E
Q
A
L
A
P
-----------------------------------------------------------
L
L
D
V
-
D
G
A
L
-
F
S
A
D
F
R
S
A
E
R
F
A
-
Q
L
Y
T
Q
V
S
G
R
-----------
K
Q
G
E
V
I
L
Q
T
H
H
----------------
P
E
H
P
L
L
Q
T
L
L
Y
K
--
G
Y
D
A
F
A
E
-
Q
A
L
A
E
R
Q
T
M
Q
L
P
P
W
T
S
H
V
L
I
R
A
E
D
H
N
-
N
Q
Q
-
A
P
L
F
--
L
----
Q
Q
L
R
N
--
L
L
Q
A
S
P
L
A
D
EK
L
W
V
L
G
P
V
P
A
L
A
-------
R
W
Q
I
L
L
Q
--
H
P
S
------
R
V
R
L
Q
H
I
V
S
G
-----------------------------
T
L
A
L
I
N
T
-
L
------
V
K
W
V
L
----
D
V
D
P
I
E
---------------------------------------------------------------------------------------------
38
Fugue
49.53
20%
19
- C2 -
-
2EYQ
3
MFD_ECOLI
A:
[5-1150]
PEQYR
Y
T
L
P
V
K
AG
E
Q
R
L
L
GELTGA
A
C
A
T
L
V
A
E
I
A
E
R
HA
G
P
V
V
L
I
A
PD
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
M
V
M
N
LADWETLPYDSFSPH
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
LPTMQ
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
KGQRLS
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
DQVMEHG
E
Y
A
T
R
GA
L
L
D
L
FPMGSE
L
P
Y
R
L
D
F
F
DDEID
S
L
R
V
F
D
VDSQRTLEEVE
A
I
N
L
L
P
AHEFPTD
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
RDPEH
I
Y
Q
Q
V
S
K
GTLPAGIEYW
Q
P
L
F
F
SEPLPPLFSYFPAN
T
L
L
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
GVDPM
R
P
L
L
P
PQSLWLR
V
D
E
L
F
S
E
L
K
N
W
P
R
V
Q
L
K
TEHLPTKAA
N
A
N
L
GFQKLPDLAVQAQQKAPL
D
A
L
R
K
F
L
E
T
FD
G
P
V
V
F
S
V
ES
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
-
Q
R
I
M
R
L
D
E
A
S
-----
D
R
G
R
Y
L
M
I
G
A
A
E
H
G
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D
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V
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N
L
A
L
I
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S
-
D
L
L
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A
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I
N
P
D
T
L
I
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N
L
A
E
L
H
I
G
Q
P
V
V
H
---
L
E
H
G
V
G
R
Y
A
G
M
-
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
D
A
K
L
Y
V
P
-
V
S
------
S
L
H
L
I
S
R
Y
A
--
G
G
A
E
E
N
A
P
----
L
H
K
--
L
G
G
D
----------------------------------
A
W
S
R
A
R
Q
K
--
A
A
E
K
V
R
D
V
A
A
E
L
-----------------------------
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
F
---------------
K
H
D
R
E
Q
Y
Q
L
-
F
C
D
S
F
-----------------------
P
F
E
T
T
P
D
Q
----------------------------------------
A
Q
A
I
N
A
V
L
S
D
M
---
C
Q
P
L
A
M
D
R
--
L
V
C
---------------
G
D
----
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
--
D
N
------------
H
K
Q
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
NWP-
V
---
R
I
E
M
I
-----
S
R
F
R
S
A
K
E
Q
T
Q
-----------
I
L
A
E
V
--
A
E
G
K
I
D
I
L
I
G
T
H
K
L
L
-----------------
Q
--------
S
------------
D
V
K
FK
D
L
--
G
L
L
I
V
D
E
E
H
R
F
G
V
R
H
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E
R
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A
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R
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V
D
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L
--
T
L
T
-
A
T
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I
P
R
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M
A
M
--
S
G
M
R
D
--
L
S
I
I
A
T
---------------------
P
P
A
R
R
L
A
-
V
K
T
F
V
R
E
Y
D
-
S
M
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A
I
L
R
E
-
I
L
R
G
G
Q
V
Y
Y
L
Y
N
D
V
E
-------------------------------------------------------------------------
N
I
Q
K
A
A
E
R
L
A
E
-
L
V
P
E
A
R
I
A
I
G
H
G
Q
M
--
R
E
R
E
L
E
R
V
M
N
D
F
H
H
Q
R
F
N
V
L
V
C
T
T
I
---
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
E
-------------
R
A
D
H
F
G
L
-
A
Q
L
H
Q
L
R
G
R
V
G
R
------
S
H
H
Q
A
Y
A
W
L
L
T
P
H
----------------
P
K
A
--
M
T
T
D
A
Q
K
--
R
L
E
A
I
A
S
L
E
D
L
G
A
G
F
A
L
A
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H
D
L
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R
G
A
G
E
L
L
G
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-
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S
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-
S
M
E
T
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F
S
L
Y
M
E
L
L
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N
--
A
--
V
D
A
L
K
A
--
G
R
--
E
P
S
L
E
D
L
T
S
Q
Q
T
E
V
E
L
R
M
P
S
L
--
L
P
D
DFIPD
V
N
T
R
L
S
F
Y
K
R
I
-----------------------------
A
S
A
K
T
E
N
-
E
L
E
E
I
-
K
V
E
L
I
D
----
R
F
G
L
L
P
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
GIR
K
L
E
G
N
EK
G
G
V
I
E
F
A
EKNHVN
P
A
W
L
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G
L
L
Q
KQPQH
Y
R
L
D
G
PT
R
L
K
F
I
Q
DLSE
R
K
T
R
I
E
W
V
R
Q
F
M
R
E
L
E
E
N
AI
50
HHSearch
42.45
19%
-52
- C2 -
-
5LST
-
?
A:
[56-463]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
F
R
P
G
----------------------------------------
Q
E
R
A
V
M
R
I
L
------
S
G
I
S
--
T
--
L
L
V
---------------
L
P
----
T
G
A
G
K
S
L
C
Y
Q
L
P
A
L
L
Y
S
--
R
R
S
-----------
P
C
L
T
L
V
V
S
P
L
L
S
L
M
D
D
Q
V
S
G
L
P
P
C
L
---------
K
A
A
C
I
-----
H
S
G
M
T
R
K
Q
R
E
S
-----------
V
L
Q
K
I
--
R
A
A
Q
V
H
V
L
M
L
T
P
E
A
L
-----------------
V
GAGGLPPA
A
------------
Q
L
P
--
P
V
--
A
F
A
C
I
D
E
A
H
C
L
S
Q
W
S
-
H
N
F
R
P
C
Y
L
R
V
C
K
V
--
L
R
E
R
M
G
V
H
C
F
L
G
L
T
A
T
--
A
T
R
R
T
--
A
S
D
V
A
Q
H
L
A
V
A
E
E
P
D
----
A
--
P
--
V
P
T
N
L
H
L
S
V
-
S
M
D
R
----
D
T
D
Q
A
L
L
T
L
L
Q
G
K
R
F
Q
N
L
D
S
I
I
I
Y
C
N
R
R
E
D
T
E
R
I
A
----------------------------
A
L
L
R
T
C
L
H
--------
A
----------
R
A
------------------------
P
K
T
T
A
E
A
Y
H
A
G
M
C
S
R
--
E
R
R
R
V
Q
R
A
F
M
Q
G
Q
L
R
V
V
V
A
T
V
A
---
F
G
M
G
L
D
R
P
D
V
R
A
V
L
H
L
G
L
-
P
P
S
F
--------------
E
S
Y
V
Q
A
V
G
R
A
G
R
------
D
G
Q
P
A
H
C
H
L
F
L
Q
P
QG--------------
E
D
L
R
E
L
R
R
H
V
H
A
--
D
S
T
D
F
L
A
-
V
K
R
L
V
Q
R
V
F
P
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
41.09
40%
-171
- C4 -
-
2D7E
-
PRIA_ECOLI
A:
[1-105]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
V
A
H
V
A
L
P
V
P
L
P
R
T
F
D
Y
L
L
P
E
G
M
--
T
V
K
A
G
C
R
V
R
V
P
F
G
K
Q
-
Q
E
R
I
--
G
I
V
V
S
V
S
D
A
S
E
-
L
P
L
N
E
L
K
A
V
V
E
V
L
D
S
E
P
V
F
T
---
H
S
--
V
W
R
L
L
L
W
-
A
A
D
Y
Y
H
H
P
I
G
D
V
L
F
H
A
L
P
I
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
40.52
17%
-31
- C2 -
-
1OYW
-
RECQ_ECOLI
A:
[24-346]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
F
R
P
G
----------------------------------------
Q
E
E
I
I
D
T
V
L
------
S
G
R
D
--
C
--
L
V
V
---------------
M
P
----
T
G
G
G
K
S
L
C
Y
Q
I
P
A
L
L
L
-----------------
N
G
L
T
V
V
V
S
P
L
I
S
L
M
K
D
Q
V
D
Q
L
Q
A
N
-
G
----
V
---
A
A
A
C
L
-----
N
S
T
Q
T
R
E
Q
Q
L
E
-----------
V
M
T
G
C
--
R
T
G
Q
I
R
L
L
Y
I
A
P
E
R
L
-----------------
M
--------
L
DN
F
L
E
H
L
-----
A
H
W
--
N
P
--
V
L
L
A
V
D
E
A
H
C
I
S
Q
W
G
-
H
D
F
R
P
E
Y
A
A
L
G
Q
L
--
R
Q
R
-
F
P
T
L
P
F
M
A
L
T
A
T
--
A
D
D
T
T
--
R
Q
D
I
V
R
L
L
G
L
N
D
P
L
I
Q
I
S
---
S
F
--
D
R
P
N
I
R
Y
M
L
-
M
E
K
F
---
K
-
P
L
D
Q
L
M
R
Y
V
Q
E
---
Q
R
G
K
S
G
I
I
Y
C
N
S
R
A
K
V
-------------------------------------------------------------------------
E
D
T
A
A
R
L
Q
S
-
K
--
G
I
S
A
A
A
Y
H
A
G
L
E
N
N
--
V
R
A
D
V
Q
E
K
F
Q
R
D
D
L
Q
I
V
V
A
T
V
A
---
F
G
M
G
I
N
K
P
N
V
R
F
V
V
H
F
D
I
-
P
R
N
I
--------------
E
S
Y
Y
Q
E
T
G
R
A
G
R
------
D
G
L
P
A
E
A
M
L
F
Y
D
P
----------------
A
D
M
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
39.24
18%
-25
- C2 -
-
4D26
2
?
A:
[71-408]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
P
T
P
I
----------------------------------------
Q
K
N
A
I
P
I
I
M
------
S
G
R
D
--
L
--
M
G
C
---------------
A
Q
----
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
--
L
Q
D
P
K
D
L
I
S
E
NG
C
A
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
----
G
SV
L
K
V
A
V
A
-----
Y
G
G
T
A
V
R
H
Q
G
D
-----------
N
I
------
A
R
G
C
H
I
L
V
A
T
P
G
R
L
-----------------
H
D
F
V
E
R
NR-
V
------------
S
F
G
--
S
V
--
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
G
---
F
M
P
S
I
E
K
M
M
L
H
PT
M
V
E
-
T
T
K
R
Q
T
L
M
F
S
A
T
--
F
P
E
D
I
--
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
-
G
A
S
-
T
D
V
E
Q
I
F
I
E
-
V
T
K
----
Y
E
K
R
N
S
L
K
Q
L
I
E
E
N
---
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
-------------------------------------------------------------------------
F
I
A
A
M
L
S
E
-
Q
--
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
--
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
---
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
-
P
K
S
I
--------------
D
E
Y
V
H
R
I
G
R
T
G
R
------
V
G
N
R
G
K
A
V
S
F
Y
D
S
----------------
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
37.49
18%
-21
- C2 -
-
4D25
3
?
A:
[71-408]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
P
T
P
I
----------------------------------------
Q
K
N
A
I
P
I
I
M
------
S
G
R
D
--
L
--
M
G
C
---------------
A
Q
----
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
--
L
Q
D
PKD
L
I
S
E
NG
C
A
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
----
G
SV
L
K
V
A
V
A
-----
Y
G
G
T
A
V
R
H
Q
G
D
-----------
N
I
------
A
R
G
C
H
I
L
V
A
T
P
G
R
L
-----------------
H
D
F
V
E
R
NR-
V
------------
S
F
G
--
S
V
--
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
G
---
F
M
P
S
I
E
K
M
M
L
H
PT
M
V
E
-
T
T
K
R
Q
T
L
M
F
S
A
T
--
F
P
E
D
I
--
Q
H
L
A
G
R
FL
N
N
Y
L
F
V
A
V
G
I
V
G
-
G
A
S
-
T
D
V
E
Q
I
F
I
E
-
V
T
K
----
Y
E
K
R
N
S
L
K
Q
L
I
E
E
N
---
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
-------------------------------------------------------------------------
F
I
A
A
M
L
S
E
-
Q
--
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
--
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
---
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
-
P
K
S
I
--------------
D
E
Y
V
H
R
I
G
R
T
G
R
------
V
G
N
R
G
K
A
V
S
F
Y
D
S
----------------
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
37.48
16%
-21
- C2 -
-
2V1X
1
RECQ1_HUMAN
A:
[43-378]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
R
P
L
----------------------------------------
Q
L
E
T
I
N
V
T
M
------
A
G
K
E
--
V
--
F
L
V
---------------
M
P
----
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
-----
S
------------
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
-
G
----
I
---
S
A
T
M
L
-----
N
A
S
S
S
K
E
H
V
K
W
-----------
V
H
A
E
M
V
N
K
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
-----------------
A
--------
K
S
K
M
F
M
S
R
L
E
K
A
Y
E
A
R
--
R
F
--
T
R
I
A
V
D
E
V
H
C
C
S
Q
W
G
-
H
D
F
R
P
D
Y
K
A
L
G
I
L
--
K
R
Q
-
F
P
N
A
S
L
I
G
L
T
A
T
--
A
T
N
H
V
--
L
T
D
A
Q
K
I
L
C
I
E
K
C
F
T
F
T
A
S
F
-----
N
R
P
N
L
Y
Y
E
V
-
R
Q
K
P
S
N
T
E
D
F
I
E
D
I
V
K
L
I
N
G
R
--
Y
K
G
Q
S
G
I
I
Y
C
F
S
Q
K
D
-------------------------------------------------------------------------
S
E
Q
V
T
V
S
L
Q
N
-
L
--
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
--
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
---
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
-
S
K
S
M
--------------
E
N
Y
Y
Q
E
S
G
R
A
G
R
------
D
D
M
K
A
D
C
I
L
Y
Y
G
F
----------------
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
37.41
17%
-16
- C2 -
-
4Q48
-
?
B:
[24-344]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
R
G
V
----------------------------------------
Q
G
E
I
V
Q
Q
V
A
------
E
G
G
N
--
A
--
L
V
L
---------------
M
P
----
T
G
G
G
K
S
L
C
Y
Q
L
P
S
L
L
-----
R
------------
P
G
T
G
I
V
V
S
P
L
I
A
L
M
K
D
Q
V
D
T
L
R
Q
N
G
-----
V
---
R
A
A
F
L
-----
N
S
T
L
L
P
H
E
A
R
E
-----------
V
E
D
A
L
--
L
R
G
D
L
D
L
L
Y
V
A
P
E
R
L
-----------------
L
--------
M
PRTLDLL-----
E
R
A
--
P
V
--
A
L
F
A
I
D
E
A
H
C
V
S
Q
W
G
-
H
D
F
R
P
E
Y
Q
Q
L
S
V
L
--
A
E
R
-
F
P
E
L
P
R
V
A
L
T
A
T
--
A
D
E
R
T
--
R
A
D
I
K
S
VL
R
L
E
D
A
P
Q
F
V
S
S
F
-----
D
R
P
N
I
Q
Y
R
V
-
G
L
K
D
---
S
-
P
K
T
Q
L
L
H
F
I
R
E
E
--
H
P
G
D
A
G
I
V
Y
C
L
S
R
K
S
-------------------------------------------------------------------------
V
E
E
T
A
K
W
L
Q
A
-
Q
--
G
I
D
A
L
A
Y
H
A
G
L
S
S
T
--
E
R
N
N
V
Q
E
R
F
L
N
E
E
G
V
I
V
C
A
T
V
A
--------
D
K
P
N
V
R
F
V
A
H
L
D
L
-
P
K
S
M
--------------
E
G
Y
Y
Q
E
T
G
R
A
G
R
------
D
G
L
P
S
T
A
W
M
V
Y
G
L
----------------
S
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
37.40
17%
12
- C2 -
-
5SUQ
3
SUB2_YEAST
A:
[83-413]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
P
S
E
V
----------------------------------------
Q
Q
H
T
I
P
Q
S
I
------
H
G
T
D
--
V
--
L
C
Q
---------------
A
K
----
S
G
L
G
K
T
A
V
F
V
L
S
T
L
Q
Q
L
--
D
P
VPG---------
E
V
A
V
V
V
I
C
N
A
R
E
L
A
Y
Q
I
R
N
E
Y
L
R
F
S
K
YMPD
V
---
K
T
A
V
F
-----
Y
G
G
T
P
I
S
K
D
A
E
-----------
L
L
K
N
---
K
D
T
A
P
H
I
V
V
A
T
P
G
R
L
-----------------
K
A
L
V
R
E
KY-
I
------------
D
L
S
--
H
V
--
K
N
F
V
I
D
E
C
D
K
V
L
E
E
--
L
D
M
R
R
D
V
Q
E
I
F
R
A
--
T
P
R
---
D
K
Q
V
M
M
F
S
A
T
--
L
S
Q
E
I
--
R
P
I
C
R
R
FL
Q
N
P
L
E
I
F
V
----------
G
L
Q
Q
Y
Y
I
K
-
L
E
E
----
R
E
K
N
R
K
L
A
Q
L
L
D
D
L
---
E
F
N
Q
V
I
I
F
V
K
S
T
T
R
A
-------------------------------------------------------------------------
N
E
L
T
K
L
L
N
A
-
S
--
N
F
P
A
I
T
V
H
G
H
M
K
Q
E
--
E
R
I
A
R
Y
K
A
F
K
D
F
E
K
R
I
C
V
S
T
D
V
---
F
G
R
G
I
D
I
E
R
I
N
L
A
I
N
Y
D
L
-
T
N
E
A
--------------
D
Q
Y
L
H
R
V
G
R
A
G
R
------
F
G
T
K
G
L
A
I
S
F
V
S
S
----------------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
37.16
26%
-28
- C2 -
-
2EYQ
-
MFD_ECOLI
A:
[600-781]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-----------------------
P
F
E
T
T
P
D
Q
----------------------------------------
A
Q
A
I
N
A
V
L
S
D
M
---
C
Q
P
L
A
--
M
D
R
L
V
C
---------------
G
D
----
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
--
D
N
------------
H
K
Q
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
NWP-
V
---
R
I
E
M
I
-----
S
R
F
R
S
A
K
E
Q
T
Q
-----------
I
L
A
E
V
--
A
E
G
K
I
D
I
L
I
G
T
H
K
L
L
-----------------
Q
--------
S
DV----------
K
F
K
--
D
L
--
G
L
L
I
V
D
E
E
H
R
F
G
V
R
H
K
E
R
I
K
A
M
R
A
N
V
D
I
L
--
T
L
T
-
A
T
P
I
P
R
T
L
N
M
A
M
--
S
G
M
R
D
--
L
S
I
I
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
36.69
21%
18
- C2 -
-
5B7I
1
CAS3_PSEAB
A:
[4-1082]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEFMN
I
L
L
V
S
Q
C
E
K
R
A
L
S
E
T
R
R
I
L
D
Q
F
A
E
R
R
G
E
R
T
W
Q
T
P
I
T
Q
A
G
L
D
T
L
R
R
L
L
K
K
S
A
R
-
R
N
T
A
--
V
A
C
H
W
I
R
G
R
D
H
S
E
L
L
W
I
V
G
D
A
S
R
F
N
A
Q
G
A
V
N
D
WHS
A
E
--
D
I
R
L
L
T
V
M
A
A
L
F
H
D
--
I
G
K
A
S
Q
A
F
Q
A
K
L
R
N
R
G
K
P
M
A
D
AYR
H
E
W
V
S
L
R
L
F
E
A
F
V
G
P
G
S
S
D
E
D
W
----
L
R
R
L
A
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K
R
E
TGD
A
W
L
S
Q
LARDDRQSAPPGPFQKSRLP
P
L
A
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A
V
G
W
L
I
V
S
H
H
RL
P
N
G
D
H
R
G
S
A
S
L
A
R
LPAPIQSQWCGARDADAKEKAACWQFPH
G
L
P
F
A
S
A
H
W
R
A
R
T
A
L
C
A
Q
S
M
L
E
RPGLLAR
G
P
A
L
L
H
D
S
Y
V
M
H
V
S
R
L
I
L
M
L
A
D
H
H
Y
S
S
LPADSRLGDPNF
P
L
H
A
N
T
D
R
DSGKLKQR
L
D
E
H
L
L
G
V
A
L
H
S
R
K
L
A
G
T
LPRLERQ
L
P
R
L
A
RH
K
G
F
T
R
R
V
E
Q
P
R
---
F
R
W
Q
D
--
K
--
A
Y
D
C
A
M
A
C
R
E
Q
A
M
E
H
G
F
F
G
L
NLAS
T
G
C
G
K
T
L
A
N
G
R
I
L
Y
A
L
A
DP
Q
R
------------
G
A
R
F
S
I
A
L
G
L
R
S
L
T
L
Q
T
G
Q
A
Y
R
E
R
L
G
----
L
GDD
D
L
A
I
L
V
G
G
S
A
Q
E
L
L
A
E
N
S
H
V
H
F
A
G
TLEDGPLR
E
W
L
G
G
--
N
S
A
G
N
R
L
L
Q
A
P
I
L
A
C
T
IDHLMPASESLRGGHQ
I
--------
A
------------
P
L
L
--
R
L
M
T
S
D
L
V
L
D
E
V
D
D
F
D
I
D
D
L
P
A
L
S
R
L
V
H
W
A
G
L
F
--------
G
S
R
V
L
L
S
S
A
T
LP
P
A
L
V
Q
G
L
F
E
A
Y
R
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--
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A
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A
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L
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L
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C
T
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H
A
A
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--
E
A
R
P
A
L
C
R
E
L
A
G
Q
M
N
T
W
M
A
D
L
H
R
C
H
H
T
E
H
QG
R
R
I
S
F
G
L
L
R
L
A
N
I
E
P
L
I
E
L
A
Q
A
I
L
A
Q
--
G
A
P
E
G
L
H
V
H
L
C
V
-
Y
H
S
R
H
--
P
L
L
V
R
S
A
I
E
R
--
Q
L
D
E
L
L
K
R
S
D
D
D
A
A
A
L
F
A
R
P
T
L
A
K
A
L
Q
A
S
T
E
R
D
H
L
F
V
V
L
A
S
P
V
A
E
V
G
R
D
H
D
Y
D
W
A
I
V
E
P
S
S
M
R
S
I
I
Q
L
A
G
R
I
R
R
HRSGFS
G
E
A
N
L
Y
L
L
S
R
N
I
R
S
L
E
GQNPAFQRPGFET
P
D
F
P
L
D
S
H
D
L
H
D
LL
D
P
A
L
L
A
R
-
I
D
A
S
P
R
I
V
E
P
F
P
L
F
P
R
S
R
L
V
D
L
E
H
R
R
L
R
A
L
M
L
A
D
D
--
P
P
S
S
L
L
G
V
P
L
--
W
--
W
Q
T
P
A
S
--
L
S
--
G
A
L
Q
T
S
Q
P
F
R
A
G
A
K
E
R
C
Y
A
L
L
PD
E
D
D
------
E
E
R
L
H
F
S
R
Y
E
EG
T
W
S
N
QDNL
L
R
N
L
D
L
T
Y
G
P
R
I
Q
T
W
GTVN
Y
R
E
E
L
V
A
M
A
G
R
E
D
L
D
L
R
Q
C
A
M
R
YG
E
V
R
L
R
E
N
T
Q
G
W
S
Y
H
PYLGFKKYN----------------------------------------------------------------------------
58
HHSearch
36.60
16%
-17
- C2 -
-
4U7D
-
RECQ1_HUMAN
C:
[43-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
R
P
L
----------------------------------------
Q
L
E
T
I
N
V
T
M
------
A
G
K
E
--
V
--
F
L
V
---------------
M
P
----
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
-----
S
------------
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
-
G
----
I
---
S
A
T
M
L
-----
N
A
S
S
S
K
E
H
V
K
W
-----------
V
H
A
E
M
VN
K
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
-----------------
A
--------
K
SKMFMSRLEKAY
E
A
R
--
R
F
--
T
R
I
A
V
D
E
V
H
C
C
S
Q
W
G
-
H
D
F
R
P
D
Y
K
A
L
G
I
L
--
K
R
Q
-
F
P
N
A
S
L
I
G
L
T
A
T
--
A
T
N
H
V
--
L
T
D
A
Q
K
IL
C
I
E
K
C
F
T
F
T
A
S
F
-----
N
R
P
N
L
Y
Y
E
V
-
R
Q
K
P
S
N
T
E
D
F
I
E
D
I
V
K
L
I
N
G
R
-
Y
-
K
G
Q
S
G
I
I
Y
C
F
S
Q
K
D
-------------------------------------------------------------------------
S
E
Q
V
T
V
S
L
Q
N
-
L
--
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
--
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
---
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
-
S
K
S
M
--------------
E
N
Y
Y
Q
E
S
G
R
A
G
R
------
D
D
M
K
A
D
C
I
L
Y
Y
G
F
----------------
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
36.45
16%
-1
* C2 *
-
2DB3
2
VASA1_DROME
A:
[77-405]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
P
T
P
I
----------------------------------------
Q
K
C
S
I
P
V
I
S
------
S
G
R
D
--
L
--
M
A
C
---------------
A
Q
----
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
--
L
E
DP
H
E
L
E
L
G----
R
P
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
----
E
SY
L
K
I
G
I
V
-----
Y
G
G
T
S
F
R
H
Q
N
E
-----------
C
I
------
T
R
G
C
H
V
V
I
A
T
P
G
R
L
-----------------
L
D
F
V
D
R
TF-
I
------------
T
F
E
--
D
T
--
R
F
V
V
L
D
E
A
D
R
M
L
D
---
M
G
F
S
E
D
M
R
R
I
M
T
H
--
V
T
M
-
R
P
E
H
Q
T
L
M
F
S
A
T
--
F
P
E
E
I
--
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
-
G
A
C
-
S
D
V
K
Q
T
I
Y
E
-
V
N
K
----
Y
A
K
R
S
K
L
I
E
I
L
S
----
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
-------------------------------------------------------------------------
F
L
A
S
F
L
S
E
-
K
--
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
--
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
---
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
-
P
S
K
I
--------------
D
D
Y
V
H
R
I
G
R
T
G
R
------
V
G
N
N
G
R
A
T
S
F
F
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
35.95
18%
14
- C2 -
-
5ELX
2
DBP5_YEAST
A:
[23-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
P
S
K
I
----------------------------------------
Q
E
R
A
L
P
L
L
L
H
----
N
P
P
R
N
--
M
--
I
A
Q
---------------
S
Q
----
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
--
N
P
EDA---------
S
P
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
----
F
---
T
-
K
-
I
-----
T
S
Q
L
I
V
P
---
D
-----------
S
F
E
K
N
--
K
Q
I
N
A
Q
V
I
V
G
T
P
G
T
V
-----------------
L
D
L
M
R
R
KL-
M
------------
Q
L
Q
--
K
I
--
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
Q
--
G
L
G
D
Q
C
I
R
V
K
R
F
--
L
P
K
---
D
T
Q
L
V
L
F
S
A
T
--
F
A
D
A
V
--
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
E
V
N
V
--
D
A
I
K
Q
L
Y
M
D
-
C
K
N
E
---
A
D
K
F
D
V
L
T
E
L
Y
G
L
---
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
-------------------------------------------------------------------------
V
L
Y
G
K
L
K
S
-
E
--
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
--
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
---
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
-
P
T
-------
L
A
N
G
Q
A
D
P
-
A
T
Y
I
H
R
I
G
R
T
G
R
------
F
G
R
K
G
V
A
I
S
F
V
H
D
----------------
K
N
S
F
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
35.84
45%
-80
- C4 -
-
2DWN
1
PRIA_ECOLI
A:
[6-105]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
P
V
P
L
P
R
T
F
D
Y
L
L
P
E
G
M
T
V
K
A
--
G
C
R
V
R
V
P
F
G
K
Q
Q
E
R
I
G
--
I
V
V
S
V
S
D
A
S
E
L
P
L
N
--
E
L
K
A
V
V
E
V
L
D
S
E
P
V
F
T
---
H
S
--
V
W
R
L
L
L
W
-
A
A
D
Y
Y
H
H
P
I
G
D
V
L
F
H
A
L
P
I
L
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
35.69
17%
11
- C2 -
-
5SUP
2
SUB2_YEAST
A:
[27-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
P
S
E
V
----------------------------------------
Q
Q
H
T
I
P
Q
S
I
------
H
G
T
D
--
V
--
L
C
Q
---------------
A
K
----
S
G
L
G
K
T
A
V
F
V
L
S
T
L
Q
Q
L
--
D
P
VPG---------
E
V
A
V
V
V
I
C
N
A
R
E
L
A
Y
Q
I
R
N
E
Y
L
R
F
S
K
YMPD
V
---
K
T
A
V
F
-----
Y
G
G
T
P
I
S
K
D
A
E
-----------
L
L
K
N
---
K
D
T
A
P
H
I
V
V
A
T
P
G
R
L
-----------------
K
A
L
V
R
E
KY-
I
------------
D
L
S
--
H
V
--
K
N
F
V
I
D
E
C
D
K
V
L
E
E
--
L
D
M
R
R
D
V
Q
E
I
F
R
A
--
T
P
R
---
D
K
Q
V
M
M
F
S
A
T
--
L
S
Q
E
I
--
R
P
I
C
R
R
FL
Q
N
P
L
E
I
F
V
D
D
E
A
-
K
L
T
L
H
G
L
Q
Q
Y
Y
I
K
-
L
E
E
----
R
E
K
N
R
K
L
A
Q
L
L
D
D
L
---
E
F
N
Q
V
I
I
F
V
K
S
T
T
R
A
-------------------------------------------------------------------------
N
E
L
T
K
L
L
N
A
-
S
--
N
F
P
A
I
T
V
H
G
H
M
K
Q
E
--
E
R
I
A
R
Y
K
A
F
K
D
F
E
K
R
I
C
V
S
T
D
V
---
F
G
R
G
I
D
I
E
R
I
N
L
A
I
N
Y
D
L
-
T
N
E
A
--------------
D
Q
Y
L
H
R
V
G
R
A
G
R
------
F
G
T
K
G
L
A
I
S
F
V
S
S
----------------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
35.66
22%
24
- C2 -
-
2EYQ
3
MFD_ECOLI
A:
[598-922]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
-----------------------
F
P
F
E
T
T
P
D
----------------------------------------
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
--
R
--
L
V
C
---------------
G
D
----
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
--
D
N
------------
H
K
Q
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
----
N
WP
V
R
I
E
M
I
-----
S
R
F
R
S
A
K
E
Q
T
Q
-----------
I
L
A
E
V
--
A
E
G
K
I
D
I
L
I
G
T
H
K
L
L
-----------------
Q
S
D------
V
------------
K
F
K
--
D
L
--
G
L
L
I
V
D
E
E
H
R
F
G
V
R
H
K
--------
E
R
I
K
A
--
M
R
---
A
N
V
D
I
L
T
L
T
A
T
--
P
I
P
R
T
--
L
N
M
A
M
S
--
G
M
R
D
L
S
I
I
A
T
P
P
--
A
--
R
R
L
A
V
K
T
F
V
-
R
------
E
Y
D
S
M
V
V
R
E
A
I
L
R
E
-
I
L
R
G
G
Q
V
Y
Y
L
Y
N
D
V
E
N
-------------------------------------------------------------------------
I
Q
K
A
A
E
R
L
A
E
-
L
V
P
E
A
R
I
A
I
G
H
G
Q
M
R
E
R
--
E
L
E
R
V
M
N
D
F
H
H
Q
R
F
N
V
L
V
C
T
T
I
---
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
E
R
A
-
D
H
F
G
------------
L
-
A
Q
L
H
Q
L
R
G
R
V
G
R
------
S
H
H
Q
A
Y
A
W
L
L
T
P
H
----------------
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
35.41
20%
15
- C2 -
-
1GM5
1
?
A:
[363-702]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
-----------------------
L
P
F
K
L
T
N
A
----------------------------------------
Q
K
R
A
H
Q
E
I
R
N
D
M
I
S
E
K
P
M
N
--
R
--
L
L
Q
---------------
G
D
----
V
G
S
G
K
T
V
V
A
Q
L
A
I
L
D
N
Y
--
E
A
------------
G
F
Q
T
A
F
M
V
P
T
S
I
L
A
I
Q
H
Y
R
R
T
V
E
S
F
S
KF
N
-
I
---
H
V
A
L
L
-----
I
G
A
T
T
P
S
E
K
E
K
-----------
I
K
S
G
L
--
R
N
G
Q
I
D
V
V
I
G
T
H
A
L
I
-----------------
Q
E
D
------
V
------------
H
F
K
--
N
L
--
G
L
V
I
I
D
E
Q
H
R
F
-------------
E
A
L
M
N
--
K
G
---
K
M
V
D
T
L
V
M
S
A
T
--
P
I
P
R
S
--
M
A
L
A
F
Y
--
G
D
L
D
V
T
V
I
D
E
M
P
--
P
--
G
R
K
E
V
Q
T
M
L
-
V
P
-----
M
D
R
V
N
E
V
Y
E
F
V
R
Q
E
-
V
M
R
G
G
Q
A
F
I
V
Y
P
L
I
-------------------------------------------------------------------------
K
S
A
V
E
M
Y
E
Y
L
S
K
E
V
F
---
K
L
G
L
M
H
G
R
L
S
Q
E
--
E
K
D
R
V
M
L
E
F
A
E
G
R
Y
D
I
L
V
S
T
T
V
---
I
E
V
G
I
D
V
P
R
A
N
V
M
V
I
E
N
P
-
E
R
F
G
------------
L
-
A
Q
L
H
Q
L
R
G
R
V
G
R
------
G
G
Q
E
A
Y
C
F
L
V
V
G
D
----------------
V
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------