@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLS1: (2017-11-04 )
MNSRVQVSYQPIIDIEFSGLHLIEASAGTGKTYTLSSLMVRIFLEKYLPGQVIATTFTRAAAAELKSRIRARLVETHRYLDAKRSLTEKEILLQAEQESDLLLQHILKHFATRIAYACERLKLVIDQLDELFVGTLDSFSQKLLREFAFESGKIERAQITDDAKTYSRQLIHDVLREWIQSQPQTVIDALYLAGELKSVDSFVKLVEDSLNFSSAHFKLPEKPTIQFEQLAQLKQLAAEIDISLLEPYYSLDGDHYKHVSGTIFRNGAFNKLFSECLPQLLQVLKQSDSILVFDGSLAVQRELVFKFLGQLADQKVFKKCPAEISDGFYQHPCIQQIQQLFGVLKNYAEQFDQLHIYLKAYFCVEVKKRLPQVLQNKGETTFSQQIRTLSEALKGEQGQRFAVFVQARYPLILVDEFQDTNQDQDDMLASIWRHPERYQKGCMIMVGDRKQAIYGFRGGDMLTFLNAYKDIQAKHGREYKLIHNHRSVADLVEVVDALFQRQIDFGEQVQYDPIRAGTRPHPVLIDQNQPNPHPLRWLMLKDKETEAQQVAWKIRDLLNQSHAGQLYFQKDAQTQTLNEDDIAVLSRNHDGLDKVQFELERLGIRVNRPSKRSVFDCTIAQDVGALLTAIFHPYDEAKVKRALISRLFAMDLKQLLQLEQTAEGLSQFMTGFDTIRELWSAQGFLVAWQQCLNQFGIWKNLVAVQSKDNERVVVNLRHLTEILSQHSEKYQGAQNLYHWYLKQLQSPLDREWELERRLSSEAGVQLMTIHQSKGLEFKIVFLLGADTPFRENNKTLNFSTQDITVSESAQTLTQRVVAIADKTYLNETELKQHEERALAEQNRLWYVALTRASHRVYALLQDTDGKSVSGLAFWKNRAEPFQHRCCTDEIILEQPPAARHLNQHINIIEIQAQHFPDQRFYSRGKTSFSYLAQHLRHKVGTDLLASQSHEAVLAEDELDQVISVETATAQPISWIKSNFPRGTLAGNFLHEIFEHIDFQCSDEWVSEIRRRFKNDYSSLWQDLLIKYQESFPEEQEAEYSLYHAVAEWLQEILSTPLYQGFRLNQLQPEHYLSECPFYLALSDRVLAMKRIQQLFAEYGMEMPELLEARSARYLNGSIDLVYFDGQRYHIADYKSNYLGENLADYSVESIAQSMALASYWLQAGLYLVALHRYLKVKMQNYDIEQHLGGATYLYLRGMNGEAEQGYYYWQPSTEFVLRLDAILGYFAEDKIA
Atome Classification :
(20 SA)
.........10........20........30........40...---------..---------..-.---50........60........70........80........90........100.......110.......120.......130.......140.......150.......160...--....170......-.180..-----------.....190.......200.......210--.......220.......230..--.....240.......250...---....260.......---270.......280.......290.......300....-...310.......320...-....---330----........340-------.....--------..-350.------......360.......370.......380.......390....-.------..400.......410.......420.......430..-.....-------440.......450.......460.......470..---.---....480.......490.......500------.-.--.--.-....510-----..-----.....520-..--.--......530...-..--------..540-------.--------......550.......560.......570.......580.....-..590.......600...-.....----610........620.......630.......640.-----------..---....650...--....660-----.-....----------------.-----------------.670--------------..----------------..-.---....----680-.........690....----...700..--....-------.710....----------....720..--..-..-----.---730...-------------....--740-...---....750.-..-------------.....760.-------.-......770.......------780.......----790--------.--.....-.800.......--810.......820.......830.......840-........850----...---....860------.......------.-870----..-......----------.-----880-..--------..---.----..---..890........900------..--------..--------..---.---.910---....-------------...920.......930.....------..940.-.------------...--------..950.......960.......970.......980.......990.......--1000......1010......1020......1030......1040......1050.....-.-1060......1070......1080.--...--..1090......1100.......--..1110......1120......1130......1140......1150......1160......1170......1180......1190......1200.-......1210......1220......1230
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNS
R
V
Q
V
S
YQ
P
I
I
D
I
E
FS
G
L
H
L
I
EASAGTG
K
T
Y
T
L
S
S
L
M
V
R
I
F
L
---------
E
K---------YL-P---G
Q
V
I
A
T
T
F
T
R
A
A
A
A
E
L
K
S
R
I
R
A
R
L
V
E
T
H
R
Y
L
D
A
K
RSL
T
E
K
E
I
L
L
QAEQES
D
L
L
L
Q
H
I
L
K
H
F
A
T
R
I
A
Y
A
C
E
R
L
K
L
V
I
D
Q
L
D
E
L
F
V
G
T
L
D
S
F
S
Q
K
L
L
R
E
F
A
FESG
K
I
E
R
A
QITD
D
A
K
T
--
Y
S
R
Q
L
I
H
D
V
L
R
E
W
-
I
Q
SQ
P
Q
-----------
T
V
I
D
A
L
Y
L
A
G
E
L
K
S
V
D
S
F
V
K
L
V
E
DSLNF--SS
A
H
F
KLPEKPTI
Q
F
E
Q
L
A
Q
L
K
--
Q
L
A
A
EI
D
I
S
L
L
E
P
Y
YSLDGDH---YKHVS
G
T
I
FRNG
A
F
---
N
K
L
F
S
E
C
L
P
Q
L
L
Q
V
L
KQSD
S
I
L
V
FDG
S
L
A
V
Q
R
E
L
V
F
K
-
F
L
G
Q
L
A
D
Q
K
V
F
K
KCP
A
E
IS-DGFY---QH-----
P
C
I
Q
Q
I
Q
Q
L
F
G
-------
V
L
K
N
Y
--------
A
E
-
Q
F
D
Q
------
L
H
I
Y
L
K
A
Y
F
C
V
E
V
K
K
R
L
P
Q
V
L
Q
NKGE
T
T
F
S
Q
Q
I
R
T
L
S
E
A
LKGE-Q------G
Q
R
F
A
V
F
V
QARY
P
L
I
L
V
DEFQDTNQ
D
Q
D
D
M
L
A
S
I
WRH-
P
E
R
YQ-------KG
C
M
I
M
VGDRK
Q
A
I
Y
GFRGG
D
M
L
T
F
L
N
A
Y
K
D
I
Q
A
K---H---GR
E
Y
K
L
IHNHR
S
V
A
D
L
V
E
V
V
D
A
L
F
Q
R
-------Q-I--D--F-GEQVQYD-----PI-----RAGTRP---H
P
--
V
--
L
I
DQNQPNPH
P
L
-
R
W
--------
L
M
LKD-------K--------ET
E
A
Q
Q
V
A
W
K
I
R
D
L
LNQSHAG
Q
L
Y
F
QKDAQTQTLNED
D
I
A
V
L
SR-NHD
G
L
D
K
V
Q
F
E
L
E
-RL
G
I
-
R
VNRP----S-KRS
V
F
D
C
T
I
A
Q
D
V
G
A
L
L
T
A
I
FHPY
D
E
A
K
V
K
R
A
L
-----------
I
S
---
R
L
F
A
M
D
L
K
Q
L
--
L
Q
L
E
Q
T
A
-----
E
-
G
L
S
Q
----------------
F
-----------------
M
T
----------------
G
F
----------------
D
T
-
I
---
R
E
L
W
----S---AQ
G
F
L
V
A
W
Q
Q
C
L
N
QFG----
I
W
K
N
L
V
A
V--QSKD-------N
E
-
R
V
V
V
N
----------
L
R
H
L
T
E
I
L
S
--
Q
H
-
S
E
-----
K
---
Y
Q
G
A
Q
N
-------------
L
Y
H
W
--
Y
L
K
-
Q
L
Q---SPLD
R
E
-
W
-
E
L
-------------
E
R
RLSS-EA-------
G
-
V
Q
L
M
T
I
HQSKG
L
E
F
K
I
------
V
F
L
LGADTPF----REN--------N--
K
T
L
N
F-STQ
D
I
T
V
S
E
S
A
--
Q
T
L
T
Q
R
V
V
A
IADKTYL
N
E
T
E
L
K
Q
H
E
E
R
A
L
A
EQ--N
R
L
W
Y
V
A
LTRA----S
H
R
---
V
Y
A
L
L
Q-------DTDGKSV------S-
G
------
L
A
-
F
W
KNRA----------E-----
P
---
F
Q--------HR---C----CT---DEI-ILEQP
P
A
A
R
H
L
-------
N
Q--------HI--------
N
I
---
I
---
E
I
Q
A---QHF
P
-------------
D
Q
R
F
Y
SRGK
T
S
F
S
Y
L
A
Q
H
L
R
H
------
K
V
G
T
D
L
-
L
------------ASQ--------SHEAVL
A
E
D
E
L
D
Q
V
I
S
VETATAQ
P
I
S
W
I
K
SNFPRGT
L
A
G
N
F
L
H
E
I
F
E
HIDFQ--C
S
D
E
W
V
S
E
I
R
R
R
F
K
N
D
Y
S
S
L
W
Q
D
L
L
I
K
Y
Q
E
SFP
E
E
Q
E
A
E
Y
S
L
Y
H
A
V
A
E
W
L
Q
E
I
L
S
T
P
L
Y-Q-GFRLNQL
Q
P
E
H
Y
L
S
EC
P
F
Y
L
AL
S
D
R
--
V
L
A
--
M
K
R
I
Q
Q
L
F
A
EYGM---E
M
P
E
L
L
E
--
A
R
SARYLNG
S
I
D
L
V
Y
FDG
Q
R
Y
H
I
ADY
K
S
N
YLGE
N
L
A
D
Y
S
V
E
S
I
A
Q
S
M
A
L
A
S
Y
W
L
Q
A
G
L
Y
L
V
A
L
H
R
Y
L
K
V
K
MQNY
D
I
E
Q
HLGG
A
T
Y
L
Y
L
RGMNGE-AE-Q
G
Y
Y
Y
WQPS
T
E
F
V
L
R
L
D
A
I
L
G
Y
F
AEDKIA
3
PsiBlast_PDB
66.62
27%
9
- C6 -
-
3K70
-
RECB_ECOLI
B:
[306-1173]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
-----
P
L
F
E
A
I
D
Q
L
L
---------------------
A
E
-
P
L
S
I
------
R
D
L
V
I
T
R
A
L
A
-
E
I
R
E
T
V
A
R
E
K
R
R
R
G
E
L
G
F
D
D
M
L
S
R
L
D
S
A
L
R
S
E
-
S
------
G
E
V
L
A
A
A
I
R
T
R
F
P
V
A
M
I
D
E
F
Q
D
T
D
P
Q
Q
Y
R
I
F
R
R
I
W
H
H
Q
P
E
-----------
T
A
L
L
L
I
G
D
P
K
Q
A
I
Y
A
F
R
G
A
D
I
F
T
Y
M
K
A
R
S
E
V
H
A
----------
H
Y
T
L
D
T
N
W
R
S
A
P
G
M
V
N
S
V
N
K
L
F
S
Q
-------
T
-
D
--
D
AF
M
-
F
R
E
I
P
F
I
-----
P
V
-----
K
S
A
G
K
N
---
Q
A
--
L
R-
F
V
F
K
G
E
T
Q
P
A
M
K
-
M
W
--------
L
M
E
G
E
SCGVGDY
Q
--------
S
T
M
A
Q
V
C
A
A
Q
I
R
D
W
L
Q
A
G
Q
R
G
E
A
L
L
M
N
G
D
D
A
R
P
V
R
A
S
D
I
S
V
L
V
R
-
S
R
Q
E
A
A
Q
V
R
D
A
L
T
-
L
L
E
I
P
S
V
Y
L
S
----
N
-
R
D
S
V
F
E
T
L
E
A
Q
E
M
L
W
L
L
Q
A
V
M
T
P
E
R
E
N
T
L
R
S
A
L
-----------
A
T
---
S
M
M
G
L
N
A
L
D
I
--
E
T
L
N
N
D
E
-----
H
-
A
W
D
V
----------------
V
-----------------
V
E
----------------
E
F
----------------
D
G
-
Y
---
R
Q
I
W
----
R
---
K
R
G
V
M
P
M
L
R
A
L
M
S
A
R
N
----
I
A
E
N
L
L
A
----
T
A
G
-------
G
E
-
R
R
L
T
D
----------
I
L
H
I
S
E
L
L
Q
--
E
A
-
G
T
-----
Q
---
L
E
S
E
H
A
-------------
L
V
R
W
--
L
S
Q
-
H
I
L
---
E
P
D
S
N
A
-
S
-
S
Q
-------------
Q
M
R
L
E
S
-
D
K
-------
H
L
V
Q
I
V
T
I
H
K
S
K
G
L
E
Y
P
L
------
V
W
L
-----
P
F
-------------------
I
T
N
F
-
R
V
Q
E
Q
A
F
Y
H
D
R
--
H
S
F
E
----
A
V
L
D
L
N
A
A
P
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S
V
D
L
A
E
A
E
R
-
L
A
E
D
--
L
R
L
L
Y
V
A
L
T
R
S
VWHC
S
L
G
---
V
A
P
L
V
R
RRGDKKG
D
T
D
V
H
Q
-------
S
-
A
------
L
G
-
R
L
L
Q
K
G
----------
E
-----
P
---
Q
D
AAGL----
R
T
---
C
IEAL
C
D
---
D
D
I
-
A
W
Q
T
A
Q
T
G
D
N
Q
-------
P
W
--------
Q
V
--------
N
D
---
V
STA
E
L
N
A
KTL
Q
R
L
P
-------------
G
D
N
W
R
V
---
T
S
Y
S
G
L
Q
Q
R
-
G
H
------
G
I
A
Q
D
L
-
M
------------
P
R
--------------
L
D
V
D
A
A
G
V
A
S
V
V
E
E
P
T
L
T
P
-----
H
Q
F
P
R
G
A
S
P
G
T
F
L
H
S
L
F
E
D
L
D
F
T
QP
V
D
P
N
W
V
R
E
--
K
L
E
L
G
G
F
E
S
Q
W
E
P
V
L
---------------------
T
E
W
I
T
A
V
L
Q
A
P
L
N
-
E
T
G
V
S
L
S
Q
L
S
A
R
N
K
Q
V
E
M
E
F
Y
L
P
I
S
E
P
--
L
I
A
SQ
L
D
T
L
I
R
Q
F
D
P
L
S
A
---
G
C
P
P
L
E
F
--
M
Q
V
R
G
M
L
K
G
F
I
D
L
V
F
R
H
E
G
R
Y
Y
L
L
D
Y
K
S
N
W
L
G
E
D
S
S
A
Y
T
Q
Q
A
M
A
A
A
M
Q
A
H
R
Y
D
L
Q
Y
Q
L
Y
T
L
A
L
H
R
Y
L
R
H
R
I
A
D
Y
D
Y
E
H
H
F
G
G
V
I
Y
L
F
L
R
G
V
D
K
E
H
P
Q
-
Q
G
I
Y
T
T
R
P
N
A
G
L
I
A
L
M
D
E
M
F
A
--------
2
PsiBlast_PDB
66.04
27%
12
- C6 -
-
1W36
-
RECB_ECOLI
B:
[306-1173]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
-----
P
L
F
E
A
I
D
Q
L
L
---------------------
A
E
-
P
L
S
I
------
R
D
L
V
I
T
R
A
L
A
-
E
I
R
E
T
V
A
R
E
K
R
R
R
G
E
L
G
F
D
D
M
L
S
R
L
D
S
A
L
R
S
E
-
S
------
G
E
V
L
A
A
A
I
R
T
R
F
P
V
A
M
I
D
E
F
Q
D
T
D
P
Q
Q
Y
R
I
F
R
R
I
W
H
H
Q
P
E
-----------
T
A
L
L
L
I
G
D
P
K
Q
A
I
Y
A
F
R
G
A
D
I
F
T
Y
M
K
A
R
S
E
V
H
A
----------
H
Y
T
L
D
T
N
W
R
S
A
P
G
M
V
N
S
V
N
K
L
F
S
Q
-------
T
-
D
--
D
AF
M
-
F
R
E
I
P
F
I
-----
P
V
-----
K
S
A
G
K
N
---
Q
A
--
L
R-
F
V
F
K
G
E
T
Q
P
A
M
K
-
M
W
--------
L
M
E
G
E
SCGVGDY
Q
--------
S
T
M
A
Q
V
C
A
A
Q
I
R
D
W
L
Q
A
G
Q
R
G
E
A
L
L
M
N
G
D
D
A
R
P
V
R
A
S
D
I
S
V
L
V
R
-
S
R
Q
E
A
A
Q
V
R
D
A
L
T
-
L
L
E
I
P
S
V
Y
L
S
----
N
-
R
D
S
V
F
E
T
L
E
A
Q
E
M
L
W
L
L
Q
A
V
M
T
P
E
R
E
N
T
L
R
S
A
L
-----------
A
T
---
S
M
M
G
L
N
A
L
D
I
--
E
T
L
N
N
D
E
-----
H
-
A
W
D
V
----------------
V
-----------------
V
E
----------------
E
F
----------------
D
G
-
Y
---
R
Q
I
W
----
R
---
K
R
G
V
M
P
M
L
R
A
L
M
S
A
R
N
----
I
A
E
N
L
L
A
----
T
A
G
-------
G
E
-
R
R
L
T
D
----------
I
L
H
I
S
E
L
L
Q
--
E
A
-
G
T
-----
Q
---
L
E
S
E
H
A
-------------
L
V
R
W
--
L
S
Q
-
H
I
L
---
E
P
D
S
N
A
-
S
-
S
Q
-------------
Q
M
R
L
E
S
-
D
K
-------
H
L
V
Q
I
V
T
I
H
K
S
K
G
L
E
Y
P
L
------
V
W
L
-----
P
F
-------------------
I
T
N
F
-
R
V
Q
E
Q
A
F
Y
H
D
R
--
H
S
F
E
----
A
V
L
D
L
N
A
A
P
E
S
V
D
L
A
E
A
E
R
-
L
A
E
D
--
L
R
L
L
Y
V
A
L
T
R
S
VWHC
S
L
G
---
V
A
P
L
V
R
RRGDKKG
D
T
D
V
H
Q
-------
S
-
A
------
L
G
-
R
L
L
Q
K
G
----------
E
-----
P
---
Q
D
AAGL----
R
T
---
C
IEAL
C
D
---
D
D
I
-
A
W
Q
T
A
Q
T
G
D
N
Q
-------
P
W
--------
Q
V
--------
N
D
---
V
STA
E
L
N
A
KTL
Q
R
L
P
-------------
G
D
N
W
R
V
---
T
S
Y
S
G
L
Q
Q
R
-
G
H
------
G
I
A
Q
D
L
-
M
------------
P
R
--------------
L
D
V
D
A
A
G
V
A
S
V
V
E
E
P
T
L
T
P
-----
H
Q
F
P
R
G
A
S
P
G
T
F
L
H
S
L
F
E
D
L
D
F
T
QP
V
D
P
N
W
V
R
E
--
K
L
E
L
G
G
F
E
S
Q
W
E
P
V
L
---------------------
T
E
W
I
T
A
V
L
Q
A
P
L
N
-
E
T
G
V
S
L
S
Q
L
S
A
R
N
K
Q
V
E
M
E
F
Y
L
P
I
S
E
P
--
L
I
A
SQ
L
D
T
L
I
R
Q
F
D
P
L
S
A
---
G
C
P
P
L
E
F
--
M
Q
V
R
G
M
L
K
G
F
I
D
L
V
F
R
H
E
G
R
Y
Y
L
L
D
Y
K
S
N
W
L
G
E
D
S
S
A
Y
T
Q
Q
A
M
A
A
A
M
Q
A
H
R
Y
D
L
Q
Y
Q
L
Y
T
L
A
L
H
R
Y
L
R
H
R
I
A
D
Y
D
Y
E
H
H
F
G
G
V
I
Y
L
F
L
R
G
V
D
K
E
H
P
Q
-
Q
G
I
Y
T
T
R
P
N
A
G
L
I
A
L
M
D
E
M
F
A
--------
34
HHSearch
65.13
26%
12
- C6 -
-
1W36
-
RECB_ECOLI
B:
[9-1174]
----------
D
P
L
R
L
P
L
Q
G
E
R
L
I
E
A
S
A
G
T
G
K
T
F
T
I
A
A
L
Y
L
R
L
L
L
---------
G
L
GGSAAFPRP
L
T
-
V
---
E
E
L
L
V
V
T
F
T
E
A
A
T
A
E
L
R
G
R
I
R
S
N
I
H
E
L
R
I
A
C
L
R
E
T
-------------
T
D
N
P
L
Y
E
R
L
L
E
E
-
I
D
D
K
A
Q
A
A
Q
W
L
L
L
A
E
R
Q
M
D
E
A
A
V
F
T
I
H
G
F
C
Q
R
M
L
N
L
N
A
F
E
S
G
M
L
F
E
Q
Q
L
I
E
D
E
S
L
--
L
R
Y
Q
A
C
A
D
F
W
R
R
H
-
C
Y
P
L
-
P
-----------
R
E
I
-
A
Q
V
V
F
E
T
W
K
G
P
Q
A
L
L
R
D
I
N
R
Y
L
Q
G
--
E
----------------
A
P
V
I
K
--
A
--------------------------
P
P
P
-
D
-
D
E
T
-
L
---
A
S
R
H
A
Q
I
V
A
-----------------
R
I
---
D
T
V
K
Q
Q
-
W
-----
R
D
A
-
V
G
E
L
D
A
L
I
E
S
S
G
I
D
RRK
F
N
RSNQA
K
W
I
D
K
I
S
A
W
A
E
EETNSYQ
L
P
E
S
L
EKPRHPLF
E
A
-
I
D
Q
L
LAEPLS
I
R
D
L
V
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T
R
A
L
A
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I
R
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A
R
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K
R
R
R
G
E
L
G
F
D
D
M
L
S
R
L
D
S
A
L
R
S
E
-
S
------
G
E
V
L
A
A
A
I
R
T
R
F
P
V
A
M
I
D
E
F
Q
D
T
D
P
Q
Q
Y
R
I
F
R
R
I
W
H
H
-
Q
---
P
-------
E
T
A
L
L
L
I
G
D
P
K
Q
A
I
Y
A
F
R
G
A
D
I
F
T
Y
M
K
A
R
S
E
V
----------
H
A
H
Y
T
L
D
T
N
W
R
S
A
P
G
M
V
N
S
V
N
K
L
F
S
Q
-------
T
D
D
--
A
--
F
M
F
R
E
I
P
F
I
-----
P
V
-----
K
S
A
G
K
N
---
Q
A
--
L
RF
V
F
K
G
E
T
Q
--
P
A
M
K
M
W
LMEGESCG
V
G
D
Y
Q
-------
S
---------
T
M
A
Q
V
C
A
A
Q
I
R
D
W
L
Q
A
G
Q
R
G
E
A
L
L
M
N
G
D
D
A
R
P
V
R
A
S
D
I
S
V
L
V
R
-
S
R
Q
E
A
A
Q
V
R
D
A
L
T
-
L
L
E
I
-
P
S
V
Y
L
----
S
N
R
D
S
V
F
E
T
L
E
A
Q
E
M
L
W
L
L
Q
A
V
M
T
P
E
R
E
N
T
L
R
S
A
L
-----------
A
T
---
S
M
M
G
L
N
A
L
D
I
--
E
T
L
N
N
D
E
-----
H
-
A
W
D
V
----------------
V
-----------------
V
E
----------------
E
F
----------------
D
G
-
Y
---
R
Q
I
W
----
R
---
K
R
G
V
M
P
M
L
R
A
L
M
S
A
R
N
----
I
A
E
N
L
L
A
----
T
A
G
-------
G
E
-
R
R
L
T
D
----------
I
L
H
I
S
E
L
L
Q
--
E
A
-
G
T
-----
Q
---
L
E
S
E
H
A
-------------
L
V
R
W
--
L
S
Q
-
H
I
L
---
E
P
D
S
N
A
S
S
-
Q
Q
-------------
M
R
L
E
S
D
-
K
H
-------
L
-
V
Q
I
V
T
I
H
K
S
K
G
L
E
Y
P
L
------
V
W
L
P
F
I
T
N
F
-----
R
V
Q
--------
E
---
Q
A
F
Y
-
H
D
R
H
S
-----------
F
E
A
V
L
D
L
N
---
A
A
P
E
S
V
D
-
L
A
E
A
E
R
L
A
E
D
--
L
R
L
L
Y
V
A
L
T
R
S
----
V
W
H
---
C
S
L
G
V
A
-------
P
L
V
R
R
R
G
DKKGDT
D
V
H
------
Q
S
-
A
L
G
R
L
L
----------
Q
-----
K
---
G
E
--------
P
Q
---
D
----
A
A
GLR
T
C
I
E
A
L
C
D
D
D
I
A
W
Q
T
AQTGDNQ
P
W
--------
Q
V
--------
N
D
---
V
---
S
T
A
E
---
L
N
A
K
-------------
T
L
Q
R
L
P
G
D
N
W
R
V
T
S
Y
S
G
L
Q
Q
R
------
G
H
G
I
A
Q
D
L
MPRLDVDAAGVA
S
V
V
--------
E
E
P
T
----------------------
L
T
P
H
Q
F
P
R
G
A
S
P
G
T
F
L
H
S
L
F
E
D
L
D
F
T
--
Q
P
V
D
P
N
-------------
W
V
R
E
K
L
E
L
G
---
G
-----
F
E
S
Q
W
E
P
V
L
T
E
W
I
T
A
V
L
Q
A
P
L
N
E
T
-
G
V
S
L
S
Q
L
S
A
R
N
K
Q
V
E
M
E
F
Y
L
P
I
S
E
P
---
L
I
--
A
S
Q
L
D
T
L
I
R
Q
F
D
P
LSA
G
C
P
P
L
E
F
--
M
Q
V
R
G
M
L
K
G
F
I
D
L
V
F
R
H
E
G
R
Y
Y
L
L
D
Y
K
S
N
W
L
G
E
D
S
S
A
Y
T
Q
Q
A
M
A
A
A
M
Q
A
H
R
Y
D
L
Q
Y
Q
L
Y
T
L
A
L
H
R
Y
L
R
H
R
I
A
D
Y
D
Y
E
H
H
F
G
G
V
I
Y
L
F
L
R
G
V
D
K
E
H
P
Q
-
Q
G
I
Y
T
T
R
P
N
A
G
L
I
A
L
M
D
E
M
F
A
G
-------
1
PsiBlast_PDB
64.93
27%
13
- C6 -
-
5MBV
-
?
B:
[307-1174]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
-----
P
L
F
E
A
I
D
Q
L
L
---------------------
A
E
-
P
L
S
I
------
R
D
L
V
I
T
R
A
L
A
-
E
I
R
E
T
V
A
R
E
K
R
R
R
G
E
L
G
F
D
D
M
L
S
R
L
D
S
A
L
R
S
E
-
S
------
G
E
V
L
A
A
A
I
R
T
R
F
P
V
A
M
I
D
E
F
Q
D
T
D
P
Q
Q
Y
R
I
F
R
R
I
W
H
H
Q
P
E
-----------
T
A
L
L
L
I
G
D
P
K
Q
A
I
Y
A
F
R
G
A
D
I
F
T
Y
M
K
A
R
S
E
V
H
A
----------
H
Y
T
L
D
T
N
W
R
S
A
P
G
M
V
N
S
V
N
K
L
F
S
Q
-------
T
-
D
--
D
AF
M
-
F
R
E
I
P
F
I
-----
P
V
-----
K
S
A
G
K
N
---
Q
A
--
L
R
-
F
V
F
K
G
E
T
Q
P
A
M
K
-
M
W
--------
L
M
E
G
E
SCG
V
G
D
Y
Q
--------
S
T
M
A
Q
V
C
A
A
Q
I
R
D
W
L
Q
A
G
Q
R
G
E
A
L
L
M
N
G
D
D
A
R
P
V
R
A
S
D
I
S
V
L
V
R
-
S
R
Q
E
A
A
Q
V
R
D
A
L
T
-
L
L
E
I
P
S
V
Y
L
S
----
N
-
R
D
S
V
F
E
T
L
E
A
Q
E
M
L
W
L
L
Q
A
V
M
T
P
E
R
E
N
T
L
R
S
A
L
-----------
A
T
---
S
M
M
G
L
N
A
L
D
I
--
E
T
L
N
N
D
E
-----
H
-
A
W
D
V
----------------
V
-----------------
V
E
----------------
E
F
----------------
D
G
-
Y
---
R
Q
I
W
----
R
---
K
R
G
V
M
P
M
L
R
A
L
M
S
A
R
N
----
I
A
E
N
L
L
A
----
T
A
G
-------
G
E
-
R
R
L
T
D
----------
I
L
H
I
S
E
L
L
Q
--
E
A
-
G
T
-----
Q
---
L
E
S
E
H
A
-------------
L
V
R
W
--
L
S
Q
-
H
I
L
---
E
P
D
S
N
A
-
S
-
S
Q
-------------
Q
M
R
L
E
S
-
D
K
-------
H
L
V
Q
I
V
T
I
H
K
S
K
G
L
E
Y
P
L
------
V
W
L
-----
P
F
-------------------
I
T
N
F
-
R
V
Q
E
Q
A
F
Y
H
D
R
--
H
S
F
E
----
A
V
L
D
L
N
A
A
P
E
S
V
D
L
A
E
A
E
R
-
L
A
E
D
--
L
R
L
L
Y
V
A
L
T
R
S
VW
H
C
S
L
G
---
V
A
P
L
V
R
RRGDKKG
D
T
D
V
H
Q
-------
S
-
A
------
L
G
-
R
L
L
Q
K
G
----------
E
-----
P
---
Q
D
A
A
G
L
----
R
T
---
C
I
E
A
L
C
D
---
D
D
I
-
A
W
Q
T
A
Q
T
G
D
N
Q
-------
P
W
--------
Q
V
--------
N
D
---
V
S
T
A
E
L
N
A
K
T
L
Q
R
L
P
-------------
G
D
N
W
R
V
---
T
S
Y
S
G
L
Q
Q
---------------------------------------------------------------
T
P
-----
H
Q
F
P
R
G
A
S
P
G
T
F
L
H
S
L
F
E
D
L
D
F
T
QP
V
D
P
N
W
V
R
E
--
K
L
E
L
G
G
F
E
S
Q
W
E
P
V
L
---------------------
T
E
W
I
T
A
V
L
Q
A
P
L
N
-
E
T
G
V
S
L
S
Q
L
S
A
R
N
K
Q
V
E
M
E
F
Y
L
P
I
S
E
P
--
L
I
A
SQ
L
D
T
L
I
R
Q
F
D
P
L
S
A
---
G
C
P
P
L
E
F
--
M
Q
V
R
G
M
L
K
G
F
I
D
L
V
F
R
H
E
G
R
Y
Y
L
L
D
Y
K
S
N
W
L
G
E
D
S
S
A
Y
T
Q
Q
A
M
A
A
A
M
Q
A
H
R
Y
D
L
Q
Y
Q
L
Y
T
L
A
L
H
R
Y
L
R
H
R
I
A
D
Y
D
Y
E
H
H
F
G
G
V
I
Y
L
F
L
R
G
V
D
K
E
H
P
Q
-
Q
G
I
Y
T
T
R
P
N
A
G
L
I
A
L
M
D
E
M
F
A
--------
54
Fugue
61.80
24%
17
- C6 -
-
1W36
-
RECB_ECOLI
B:
[1-1174]
M
S
D
V
A
E
T
--
L
D
P
L
R
L
P
L
Q
G
E
R
L
I
E
A
S
A
G
T
G
K
T
F
T
I
A
A
L
Y
L
R
L
L
L
GLGGSAAFP
R
P
---------
L
T
-
V
---
E
E
L
L
V
V
T
F
T
E
A
A
T
A
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L
R
G
R
I
R
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N
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A
C
L
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T
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N
P
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Y
E
R
L
L
E
E
I
D
D
--------------
K
A
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A
A
Q
W
L
L
L
A
E
R
Q
M
D
E
A
A
V
F
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H
G
F
C
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M
L
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L
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A
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Q
L
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E
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L
--
L
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W
R
R
H
-
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Y
P
L
P
R
-----------
E
I
A
Q
V
V
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--
W
K
G
P
Q
A
L
L
R
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A
L
---
I
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S
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------------------------------------
I
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R
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R
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A
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S
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L
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-
E
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L
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---
K
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-----
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P
L
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-------
A
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--------
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A
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L
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A
L
R
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E
-
S
------
G
E
V
L
A
A
A
I
R
T
R
F
P
V
A
M
I
D
E
F
Q
D
T
D
P
Q
Q
Y
R
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F
R
R
I
W
H
H
-
Q
P
----------
E
T
A
L
L
L
I
G
D
P
K
Q
A
I
Y
A
F
R
G
A
D
I
F
T
Y
M
K
A
R
S
E
V
H
----------
A
H
Y
T
L
D
T
N
W
R
S
A
P
G
M
V
N
S
V
N
K
L
F
S
Q
-------
T
-
D
--
D
AF
M
-
F
R
E
I
P
F
I
-----
P
V
-----
K
S
A
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N
---
Q
A
--
L
--
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F
K
G
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Q
P
A
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-
K
M
--------
W
L
M
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-------
E
SCGVGDYQ
S
T
M
A
Q
V
C
A
A
Q
I
R
D
W
L
Q
A
G
Q
R
G
E
A
L
L
M
N
G
D
D
A
R
P
V
R
A
S
D
I
S
V
L
V
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-
S
R
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A
A
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V
R
D
A
L
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-
L
L
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I
-
P
S
V
Y
L
----
S
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R
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V
F
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T
L
E
A
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E
M
L
W
L
L
Q
A
V
M
T
P
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R
E
N
T
L
R
S
A
L
-----------
A
T
---
S
M
M
G
L
N
A
L
D
I
--
E
T
L
N
N
D
E
-----
H
-
A
W
D
V
----------------
V
-----------------
V
E
----------------
E
F
----------------
D
G
-
Y
---
R
Q
I
W
----
R
---
K
R
G
V
M
P
M
L
R
A
L
M
S
A
R
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----
I
A
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N
L
L
A
----
T
A
G
-------
G
E
-
R
R
L
T
D
----------
I
L
H
I
S
E
L
L
Q
--
E
A
-
G
T
-----
Q
---
L
E
S
E
H
A
-------------
L
V
R
W
--
L
S
Q
-
H
I
L
---
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P
D
S
N
A
-
S
-
S
Q
-------------
Q
M
R
L
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S
-
D
K
H------
L
-
V
Q
I
V
T
I
H
K
S
K
G
L
E
Y
P
L
------
V
W
L
P
F
I
T
N
F
R
----
V
Q
E
--------
Q
--
A
F
Y
H
D
-
R
H
S
F
E
A
V
L
D
L
N
--
A
---------------
A
P
E
S
V
D
L
A
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A
E
R
L
A
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D
--
L
R
L
L
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A
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S
----
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W
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---
C
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L
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A
-------
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L
V
R
R
R
G
------
D
-
K
-------
K
-
G
D
T
D
V
H
----------
Q
-----
S
---
A
L
--------
G
R
---
L
----
L
Q
---
K
G
E
-
P
Q
D
A
A
G
L
R
T
C
I
-------
E
A
LC------
D
D
--------
D
I
---
A
---
W
Q
T
A
---
Q
T
G
D
-------------
N
Q
P
W
Q
V
N
D
V
S
T
A
E
L
N
A
K
T
L
Q
R
------
L
P
G
D
N
W
-
R
------------
V
T
S
YSGLQQRG
H
G
I
A
Q
D
L
M
P
R
L
D
V
D
A
A
G
V
A
S
V
V
E
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P
T
L
T
P
H
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F
P
R
G
A
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P
G
T
F
L
H
S
L
F
E
D
L
D
F
T
---
Q
P
V
D
P
N
W
V
R
E
K
L
E
L
--------------------
G
G
F
E
S
Q
W
E
P
V
L
T
E
W
I
T
A
V
L
Q
A
P
L
N
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T
-
G
V
S
L
S
Q
L
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A
R
N
K
Q
V
E
M
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F
Y
L
P
I
S
E
P
LI
A
S
Q
--
L
D
T
L
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R
Q
F
D
P
L
S
A
---
G
C
P
P
L
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F
--
M
Q
V
R
G
M
L
K
G
F
I
D
L
V
F
R
H
E
G
R
Y
Y
L
L
D
Y
K
S
N
W
L
G
E
D
S
S
A
Y
T
Q
Q
A
M
A
A
A
M
Q
A
H
R
Y
D
L
Q
Y
Q
L
Y
T
L
A
L
H
R
Y
L
R
H
R
I
A
D
Y
D
Y
E
H
H
F
G
G
V
I
Y
L
F
L
R
G
V
D
K
E
-
H
P
Q
Q
G
I
Y
T
T
R
P
N
A
G
L
I
A
L
M
D
E
M
F
A
G
-------
36
HHSearch
49.91
21%
12
- C6 -
-
3U4Q
-
ADDA_BACSU
A:
[345-1214]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
L
V
I
S
Y
G
K
R
F
E
A
A
K
Q
E
K
S
I
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F
S
D
L
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H
Y
C
L
A
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A
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-
N
DRE---
P
S
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A
A
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F
Y
Q
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Q
F
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V
L
V
D
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Y
Q
D
T
N
L
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Q
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L
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L
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-
P
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--
E
-------
T
G
N
L
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K
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R
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R
L
A
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P
L
L
F
L
S
K
Y
K
R
F
T
E
S
GEG
T
---
G
R
K
I
D
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
-------
L
M
G
--
G
--
K
-
I
G
E
V
D
Y
D
-----
E
Q
AELKL
G
A
A
Y
P
D
NDE
T
E
T
E
L
L
-
L
I
D
---------------------
L
E
T
V
-------
Q
---------
F
E
A
K
A
I
A
K
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I
R
K
L
I
S
S
P
F
K
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--
Y
---
K
K
T
H
R
N
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Y
R
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I
L
L
R
-
S
M
P
W
A
P
Q
I
M
E
E
L
R
-
A
Q
G
I
-
P
V
Y
A
N
----
L
-
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
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D
N
P
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D
I
P
L
A
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L
-----------
R
S
---
P
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V
G
A
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N
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--
S
L
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L
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N
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A
-
P
Y
Y
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----------------
A
M
K
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GDRSD
E
L
Y
Q
K
L
N
----------------
T
F
----------------
Y
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---
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K
W
R
A
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K
---
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H
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----
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Y
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G
G
----
M
P
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-------
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K
-
Q
R
Q
A
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----------
L
R
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L
Y
D
R
A
R
--
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Y
-
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S
T----
A
---
F
R
G
L
F
R
-------------
F
L
R
F
--
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R
-
M
Q
E
---
R
G
D
--------------------------
Q
-
E
D
-------
V
-
V
R
L
M
T
I
H
S
S
K
G
L
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F
P
V
------
V
F
V
A
G
L
G
R
N
-----
F
N
M
--------
M
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N
K
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Y
L
L
D
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L
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--
G
T
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---
L
F
L
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-------
C
K
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K
Q
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-----
A
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K
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A
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---------
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A
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---
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---
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------
F
A
F
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A
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L
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WTYPH
Q
E
V
T
Q
I
R
T
K
Q
S
V
S
--------DEYSGR----------------------
Y
--------
R
R
P
A
F
M
----------------------
M
K
K
G
L
T
A
A
E
K
G
T
A
M
H
T
V
M
Q
H
I
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--
H
V
P
S
I
E
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---------
A
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T
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L
Y
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K
E
L
--
L
T
-
E
--
E
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D
A
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A
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W
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L
A
L
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A
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--
E
--------------------
I
Y
P
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A
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--
A
D
E
P
L
L
V
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G
I
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C
L
Y
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T
E
D
G
L
Y
L
L
A
Y
K
S
D
R
I
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------
G
F
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A
A
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I
L
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K
R
Y
E
T
Q
I
Q
L
Y
T
K
A
V
E
Q
I
A
K
T
----------------------------------------------------------
35
HHSearch
48.84
21%
32
- C6 -
-
4CEJ
1
ADDA_BACSU
A:
[345-1214]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
L
V
I
S
Y
G
K
R
F
E
A
A
K
Q
E
K
S
I
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L
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H
Y
C
L
A
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-
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DKG
E
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P
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E
A
A
R
F
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L
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D
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D
T
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L
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L
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L
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T
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G
-
P
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--
E
-------
T
G
N
L
F
M
V
G
D
V
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R
F
R
L
A
E
P
L
L
F
L
S
K
Y
K
R
F
T
E
S
GEG
T
---
G
R
K
I
D
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
-------
L
M
G
--
G
--
K
-
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G
E
V
D
Y
D
-----
E
Q
AELKL
G
A
A
Y
P
D
NDE
T
E
T
E
L
L
-
L
I
D
--------------------
E
L
E
T
V
-------
Q
---------
F
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A
K
A
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A
K
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L
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P
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A
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A
L
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L
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P
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D
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L
A
S
V
L
-----------
R
S
---
P
I
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G
A
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E
N
E
L
--
S
L
I
R
L
E
N
KK---
A
-
P
Y
Y
E
----------------
A
M
K
D
Y
L
A
A
GDRSD
E
L
Y
Q
K
L
N
----------------
T
F
----------------
Y
G
-
H
---
L
Q
K
W
R
A
F
S
K
---
N
H
S
V
S
E
L
I
W
E
V
Y
R
D
T
K
----
Y
M
D
Y
V
G
G
----
M
P
G
-------
G
K
-
Q
R
Q
A
N
----------
L
R
V
L
Y
D
R
A
R
--
Q
Y
-
E
S
T
----
A
---
F
R
G
L
F
R
-------------
F
L
R
F
--
I
E
R
-
M
Q
E
---
R
G
D
--
D
-
L
G
T
A
-------------
R
G
L
S
E
Q
-
E
D
-------
V
-
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
------
V
F
V
A
G
L
G
R
N
-----
F
N
M
--------
M
DL
N
K
S
Y
L
L
D
K
E
L
G
F
--
G
T
K
--
Y
I
H
P
Q
L
R
I
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Y
P
-
T
L
P
L
I
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M
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K
-
K
M
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R
E
L
L
S
E
E
--
L
R
V
L
Y
V
A
L
T
R
A
----
K
E
K
---
L
F
L
I
G
S
-------
C
K
D
H
Q
K
Q
L
-----
A
-
K
W
Q
A
S
A
S
Q
T
D
W
L
L
P
E
F
----------
D
-----
R
Y
Q
A
R
T
Y
L
D
F
I
G
P
A
L
A
RHR
D
----
L
-----
H
A
-
D
I
S
G
H
P
A
R
F
A
V
Q
MIHS--
Y
D
LLDERMEE
K
S
E
R
L
E
A
I
R
R
G
E
---
P
---
V
P
G
S
---
F
A
F
D
E
K
A
R
E
Q
L
S
WTYPH
Q
E
V
T
Q
I
R
T
K
Q
S
V
S
E
I
K
R
--------------------------------
Y
--------
R
R
P
A
F
M
----------------------
M
K
K
G
L
T
A
A
E
K
G
T
A
M
H
T
V
M
Q
H
I
P
L
S
--
H
V
P
S
I
E
E
---------
A
E
Q
T
V
H
R
L
Y
E
K
E
L
--
L
T
-
E
--
E
-
Q
-
K
D
A
I
D
I
E
E
I
V
Q
F
F
H
T
E
I
G
-
G
-
Q
L
----
I
G
A
K
W
K
D
R
E
I
P
F
S
L
A
L
P
A
K
--
E
--------------------
I
Y
P
D
A
H
E
--
A
D
E
P
L
L
V
Q
G
I
I
D
C
L
Y
E
T
E
D
G
L
Y
L
L
A
Y
K
S
D
R
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K
--
F
Q
H
G
F
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G
A
A
P
I
L
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K
R
Y
E
T
Q
I
Q
L
Y
T
K
A
V
E
Q
I
A
K
T
----------------------------------------------------------
55
Fugue
48.23
20%
43
- C6 -
-
3U4Q
-
ADDA_BACSU
A:
[10-1232]
---
T
W
T
D
D
Q
W
N
A
I
V
S
T
G
Q
D
I
-
L
V
A
A
A
A
G
S
G
K
T
A
V
L
V
E
R
M
I
R
K
I
T
---------
A
E
---------
E
N
-
P
I
D
V
D
R
L
L
V
V
T
F
T
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A
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A
A
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K
H
R
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A
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A
L
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K
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V
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P
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S
-----------------------------------
L
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L
L
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L
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-
Y
A
K
G
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K
-----------
A
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F
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L
V
D
R
Y
T
T
D
R
H
D
L
D
L
Q
F
L
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K
Q
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Y
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Y
--
S
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H
-
P
N
P
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L
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--
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K
E
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V
---
L
N
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A
K
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K
L
L
R
A
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L
---
T
D
N
F
L
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L
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K
L
L
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K
L
K
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---
T
R
-----
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-
P
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Q
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L
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L
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-------
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--------
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-
T
L
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Q
------
L
V
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Y
G
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R
F
--
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A
A
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K
S
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D
F
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L
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C
L
A
I
L
T
A
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N
---
D
R
-
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------
P
S
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A
A
R
F
Y
Q
E
Q
F
H
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V
L
V
D
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L
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-
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--
E
-------
T
G
N
L
F
M
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G
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F
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L
A
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P
L
L
F
L
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K
Y
K
R
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---
G
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T
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K
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L
N
K
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A
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N
F
L
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-------
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-
M
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--
I
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V
D
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-----
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Q
-----
A
E
L
K
L
G
---
A
A
------
Y
P
D
N
D
E
T
E
T
E
L
-
L
L
--------
I
D
L
E
T
-------
V
--------
Q
F
E
A
K
A
I
A
K
E
I
R
K
L
I
S
S
P
F
K
-----
V
Y
K
K
T
H
R
N
I
Q
Y
R
D
I
V
I
L
L
R
-
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W
A
P
Q
I
M
E
E
L
R
-
A
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G
I
-
P
V
Y
A
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----
L
-
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
P
Y
Q
D
I
P
L
A
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V
L
-----------
R
S
---
P
I
V
G
A
D
E
N
E
L
--
S
L
I
R
L
E
N
-----
K
-
K
A
P
Y
----------------
Y
-----------------
E
A
----------------
M
K
----------------
D
Y
-
L
---
A
A
G
D
----
R
---
S
D
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L
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L
N
T
F
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Q
----
K
W
R
A
F
S
K
N
--
H
S
V
S
-------
E
L
I
W
E
V
Y
R
----------
D
T
K
Y
M
D
Y
V
G
--
G
M
-
P
G
-----
G
---
K
Q
R
Q
A
N
-------------
L
R
V
L
--
Y
D
R
-
A
R
Q
Y
E
S
T
A
F
R
G
L
-
F
-
R
F
-------------
L
R
F
I
E
R
-
M
Q
E
RGDQED
V
-
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
------
V
F
V
A
G
L
G
R
N
F
----
N
M
M
--------
D
L-
N
K
S
Y
L
-
L
D
K
E
L
G
F
G
T
K
Y
--
I
H
P
Q
L
R
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Y
---
P
T
L
P
L
I
A
M
K
K
K
M
R
R
E
L
L
S
E
E
--
L
R
V
L
Y
V
A
L
T
R
A
----
K
E
K
---
L
F
L
I
G
S
-------
C
K
D
H
Q
K
Q
------
L
-
A
------
K
W
-
Q
A
S
A
S
Q
----------
T
DWLLP
E
---
F
D
--------
R
Y
---
Q
----
A
R
---
T
Y
L
-
D
F
I
G
P
A
L
A
R
H
R
-------
H
A
--------
D
I
--------
S
G
HP-
A
---
R
F
A
V
---
Q
M
I
H
-------------
S
Y
D
S
E
R
L
E
A
I
R
R
G
E
P
V
F
A
F
D
E
------
K
A
R
E
Q
L
-
S
------------
W
T
Y
--------
P
H
Q
E
V
T
Q
I
R
T
K
Q
S
V
S
D
E
Y
S
G
R
Y
R
R
P
A
F
M
M
K
K
G
L
T
A
A
E
K
G
T
A
M
H
T
V
M
Q
H
I
P
L
S
HV
P
S
I
E
E
A
E
Q
T
V
H
R
L
Y
E
-------------
K
E
L
L
T
E
E
Q
K
D
A
I
D
-
I
E
E
I
V
Q
F
F
H
T
E
I
G
G
Q
L
I
-
G
-
A
K
W
K
D
R
--------
E
I
P
F
S
L
A
L
P
A
K
--
E
I
--------------------
Y
P
D
A
H
E
--
A
D
E
P
L
L
V
Q
G
I
I
D
C
L
Y
E
T
E
D
G
L
Y
L
L
A
Y
K
S
D
R
I
E
G
G
F
E
G
------
A
A
P
I
L
K
K
R
Y
E
T
Q
I
Q
L
Y
T
K
A
V
E
Q
I
A
K
T
K
V
K
G
----------
C
A
L
Y
F
---------------
F
D
G
G
H
I
L
T
L
---------------
5
PsiBlast_PDB
44.05
27%
34
- C6 -
-
4CEJ
1
ADDA_BACSU
A:
[381-961]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
N
D
K
G
E
R
E
------
P
S
E
A
A
R
F
Y
Q
E
Q
F
H
E
V
L
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
S
G
-
P
E
--
E
-------
T
G
N
L
F
M
V
G
D
V
K
Q
S
I
Y
R
F
R
L
A
E
P
L
L
F
L
S
K
Y
K
R
F
T
E
S
---
G
EG
T
G
R
K
I
D
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
L
MGGKIG
E
-
V
--
D
--
Y
-
D
E
Q
A
E
L
K
LG
A
A
Y
P
D
-----
N
D
E
T
E
T
---
E
L
--
L
--
L
I
D
---------------------
E
L
E
T
-------
V
--------
Q
F
E
A
K
A
I
A
K
E
I
R
K
L
I
--
S
S
P
F
K
V
Y
D
G
K
K
K
T
H
R
N
I
Q
Y
R
D
I
V
I
L
L
R
-
S
M
P
W
A
P
Q
I
M
E
E
L
R
-
A
Q
G
I
-
P
V
Y
A
N
----
L
-
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
I
D
N
P
Y
Q
D
I
P
L
A
S
V
L
-----------
R
S
---
P
I
V
G
A
D
E
N
E
L
S
L
I
R
L
E
N
K
K
AP
Y
Y
-
E
-
A
M
K
D
----------------
Y
-----------------
L
A
----------------
A
G
----------------
D
R
-
S
---
D
E
L
Y
Q
K
L
N
T
---
F
Y
G
H
L
Q
K
W
R
A
F
S
K
N
H
S
V
S
E
L
I
W
E
V
Y
R
D
T
--
K
Y
M
D
Y
V
G
G
MPG
G
K
-
Q
R
Q
A
N
----------
L
R
V
L
Y
D
R
A
R
--
Q
Y
E
S
T
-----
A
---
F
R
G
----------------
L
F
R
F
L
R
F
I
E
-
R
M
Q
---
E
R
G
D
-
D
-
L
-
G
T
-------------
A
R
G
L
S
E
Q
E
D
-------
V
-
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
------
V
F
V
A
G
L
G
R
N
F
----
N
M
M
DLNKS
Y
L
L
D
--
K
E
L
G
F
-
G
T
K
Y
I
H
P
Q
L
R
I
--
S
Y
P
T
L
P
L
I
A
M
K
----------
K
K
M
R
R
E
L
L
S
E
E
--
L
R
V
L
Y
V
A
L
T
R
A
----
K
E
K
---
L
F
L
I
G
S
-------
C
K
D
H
Q
--------
K
-
Q
------
L
A
-
K
W
Q
A
S
A
SQTDWLLP
E
F
D
-----
R
---
Y
Q
--------
A
R
---
T
----
Y
L
---
D
F
I
----
G
P
A
L
A
R
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
43.08
27%
35
- C6 -
-
4CEI
1
ADDA_BACSU
A:
[381-976]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
N
D
K
G
E
R
E
------
P
S
E
A
A
R
F
Y
Q
E
Q
F
H
E
V
L
V
D
E
Y
Q
D
T
N
L
V
Q
E
S
I
L
Q
L
V
T
S
G
-
P
E
--
E
-------
T
G
N
L
F
M
V
G
D
V
K
Q
S
I
Y
R
F
R
L
A
E
P
L
L
F
L
S
K
Y
K
R
F
T
E
S
---
G
EG
T
G
R
K
I
D
L
N
K
N
F
R
S
R
A
D
I
L
D
S
T
N
F
L
F
K
Q
LMGGKIG
E
-
V
--
D
--
Y
-
D
E
Q
A
E
L
K
LGAAY
P
D
-----
N
D
E
T
E
T
---
E
L
--
L
--
L
I
D
N
----------
A
--------
E
E
L
E
T
-------
V
--------
Q
F
E
A
K
A
I
A
K
E
I
R
K
L
I
--
S
S
P
F
K
V
Y
D
G
K
K
K
T
H
R
N
I
Q
Y
R
D
I
V
I
L
L
R
-
S
M
P
W
A
P
Q
I
M
E
E
L
R
-
A
Q
G
I
-
P
V
Y
A
N
----
L
-
T
S
G
Y
F
E
A
V
E
V
A
V
A
L
S
V
L
K
V
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V
L
-----------
R
S
---
P
I
V
G
A
D
E
N
E
L
S
L
I
R
L
E
N
K
K
AP
Y
Y
-
E
-
A
M
K
D
----------------
Y
-----------------
L
A
----------------
A
G
----------------
D
R
-
S
---
D
E
L
Y
Q
K
L
N
T
---
F
Y
G
H
L
Q
K
W
R
A
F
S
K
N
H
S
V
S
E
L
I
W
E
V
Y
R
D
T
--
K
Y
M
D
Y
V
G
G
MPG
G
K
-
Q
R
Q
A
N
----------
L
R
V
L
Y
D
R
A
R
--
Q
Y
E
S
T
-----
A
---
F
R
G
----------------
L
F
R
F
L
R
F
I
E
-
R
M
Q
---
E
R
G
D
-
D
-
L
-
G
T
-------------
A
R
G
L
S
E
Q
E
D
-------
V
-
V
R
L
M
T
I
H
S
S
K
G
L
E
F
P
V
------
V
F
V
A
G
L
G
R
N
F
----
N
M
M
DLNKS
Y
L
L
D
--
K
E
L
G
F
-
G
T
K
Y
I
H
P
Q
L
R
I
--
S
Y
P
T
L
P
L
I
A
M
K
----------
K
K
M
R
R
E
L
L
S
E
E
--
L
R
V
L
Y
V
A
L
T
R
A
----
K
E
K
---
L
F
L
I
G
S
-------
C
K
D
H
Q
--------
K
-
Q
------
L
A
-
K
W
Q
A
S
A
SQTDWLLP
E
F
D
-----
R
---
Y
Q
--------
A
R
---
T
----
Y
L
---
D
F
I
----
G
P
A
L
A
R
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
36.84
39%
-140
- C6 -
-
1QHH
1
PCRA_GEOSE
A:
[28-80]
---------------------
L
I
M
A
G
A
G
S
G
K
T
R
V
L
T
H
R
I
A
Y
L
M
A
---------
E
K
---------
H
V
A
P
---
W
N
I
L
A
I
T
F
T
N
K
A
A
R
E
M
R
E
R
V
Q
S
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
36.70
22%
7
- C6 -
-
4C2U
2
?
A:
[177-631]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
E
A
Y
R
R
Y
E
V
R
K
K
G
Q
N
A
I
D
F
G
D
L
I
T
E
T
V
R
L
F
K
E
V
---------
P
G
V
L
D
K
V
Q
N
K
A
K
F
I
H
V
D
E
Y
Q
D
T
N
R
A
Q
Y
E
L
T
R
L
L
A
S
R
-
D
------------
R
N
L
L
V
V
G
D
P
D
Q
S
I
Y
K
F
R
G
A
D
I
Q
N
I
L
D
F
Q
K
D
Y
P
-----
D
---
A
K
V
Y
M
L
E
H
N
Y
R
S
S
A
R
V
L
E
A
A
N
K
L
I
E
N
-------
N
-
T
-----
E
----
R
L
D
K
-----
T
L
-----
K
P
V
K
----------------
E
A
G
--
Q
P
V
T
F
H
--------
R
A
T
D
H
-------
R
---------
A
E
G
D
Y
V
A
D
W
L
T
R
L
H
G
---------------
E
G
R
A
W
S
E
M
A
I
L
Y
R
-
T
N
A
Q
S
R
V
I
E
E
S
L
R
-
R
V
Q
I
-
P
A
R
I
V
----
G
-
G
V
G
F
Y
D
R
R
E
I
R
D
I
L
A
Y
A
R
L
A
L
N
P
A
D
D
V
A
L
R
R
I
I
-----------
G
R
---
P
R
R
G
I
G
D
T
A
L
--
Q
K
L
M
E
W
A
-----
R
T
H
H
T
S
----------------
V
-----------------
L
T
----------------
A
C
A
N
A
AEQNILDRG
A
H
K
A
T
E
-
F
A
G
L
M
E
A
M
S
E
A
A
D
---
N
Y
E
P
A
A
F
L
R
F
V
M
E
T
S
G
----
Y
L
D
L
L
R
Q
E
---
G
Q
E
-------
G
Q
-
V
R
L
E
N
----------
L
E
E
L
V
S
A
A
E
--
E
W
-
S
Q
D----
E
ANV
G
G
S
I
A
D
-------------
F
L
D
D
--
A
A
L
-
L
S
S
---
V
D
-
D
M
R
-
T
-
K
A
-------------
E
N
K
G
A
P
-
E
D
-------
A
-
V
T
L
M
T
L
H
N
A
K
G
L
E
F
P
V
------
V
F
I
V
G
V
E
Q
G
-----
L
L
P
--------
S
--
K
-
G
A
------------------------
I
------------
A
E
G
P
S
G
I
E
E
E
--
R
R
L
F
Y
V
G
I
T
R
A
----
M
E
R
---
L
L
M
T
A
A
-------
Q
N
R
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
36.17
20%
-5
- C6 -
-
1UAA
1
REP_ECOLI
A:
[165-616]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
C
Y
G
L
Y
D
A
H
L
K
A
C
N
V
L
D
F
D
D
L
I
L
L
P
T
L
L
L
Q
A
N
---------
E
E
V
R
K
R
W
Q
N
K
I
R
Y
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
-------------
R
A
R
F
T
V
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
P
Q
N
L
V
L
L
S
Q
D
F
P
-----
A
---
L
K
V
I
K
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
-------
N
-
P
--
H
------
V
F
E
-
K
-----
R
L
-----
F
S
E
L
----------------
G
Y
G
--
A
E
L
K
V
L
--------
S
A
N
N
E
-------
E
---------
H
E
A
E
R
V
T
G
E
L
I
A
H
H
F
V
--------------
N
K
T
Q
Y
K
D
Y
A
I
L
Y
R
-
G
N
H
Q
S
R
V
F
E
K
F
L
M
-
Q
N
R
I
-
P
Y
K
I
S
----
G
-
G
T
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
-----------
N
T
---
P
K
R
E
I
G
P
A
T
L
--
K
K
L
G
E
W
A
M
T
R
NK
S
-
M
F
T
A
SFDMGLSQTLSG
R
G
Y
E
A
-----------------
L
T
----------------
R
F
----------------
T
H
-
W
---
L
A
E
I
----
Q
R
L
A
E
R
E
P
I
A
A
V
R
D
L
I
H
G
M
D
----
Y
E
S
W
L
Y
E
T
SP
S
P
K
A
-------
A
E
-
M
R
M
K
N
----------
V
N
Q
L
F
S
W
M
T
--
E
M
-
L
E
GSELD
E
---
P
M
T
L
T
Q
-------------
V
V
T
R
--
F
T
L
-
R
D
M
---
M
------
E
--
R
----------------
E
E
E
-
L
D
-------
Q
-
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
------
V
Y
M
V
G
M
E
E
G
-----
F
L
P
--------
H
--
Q
-
S
--------------------------------------
S
I
D
E
D
N
I
D
E
E
--
R
R
L
A
Y
V
G
I
T
R
A
----
Q
K
E
---
L
T
F
T
L
C
-------
K
E
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
35.71
17%
7
- C5 -
-
2EYQ
3
MFD_ECOLI
A:
[5-1150]
---
P
E
Q
Y
R
Y
T
L
P
V
K
A
G
-------
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
---------
E
R
---------
H
--
A
---
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
--------------
T
D
Q
M
V
M
N
L
A
D
W
E
T
-----
L
P
Y
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
-
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
--
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
VMEHG
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
TD
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
R
D
P
EH
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
YW
Q
P
L
F
F
S
E
P
L
P
P
L
F
S
Y
F
P
-
A
N
T
L
L
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
P
M
R
P
L
L
P
P
-
Q
S
L
W
---
L
----------
R
V
D
E
L
F
S
-------
E
L
K
N
W
--------
P
R
V
Q
L
K
T
------
E
H
L
P
T
K
A
A
N
A
N
L
G
F
Q
K
L
P
D
L
A
V
Q
A
Q
Q
K
A
P
L
D
A
L
R
K
F
L
E
T
F
D
G
---------------------
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
-
P
Q
R
I
M
RLDEASD
R
G
R
Y
L
M
I
G
---
A
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
G
E
---
R
---
V
A
R
R
R
--
Q
D
S
R
R
T
I
N
P
D
T
L
I
R
N
L
--
A
-------
E
-
L
--
H
--
I
-
G
Q
P
V
V
H
L
-----
E
H
-----
G
V
G
R
Y
A
---
G
-------
M
T
T
L
E
A
G
G
I
T
G
-
E
Y
--------
L
M
L
T
Y
-------
A
--------
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
---
E
E
N
A
P
L
H
K
L
G
G
D
--
A
W
S
R
A
-
R
Q
K
A
A
E
K
V
R
D
V
A
A
-
E
L
L
D
-
I
Y
A
Q
R
----
A
-
A
K
E
G
F
A
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
-
P
F
E
T
T
P
D
Q
A
Q
A
-----------
I
N
---
A
V
L
S
-
D
M
C
Q
P
--
L
A
M
D
R
L
V
-----
C
-
G
D
V
G
----------------
F
-----------------
G
K
-----------------------------------------
T
E
V
A
----
M
---
R
A
A
F
L
A
V
--------------------------
D
-------
N
H
-
K
Q
V
A
V
----------
L
V
P
T
T
L
L
A
Q
--
Q
H
-
Y
D
-----
N
---
F
R
D
R
F
A
-------------
N
W
P
V
--
R
I
E
-
M
I
S
---
R
F
R
S
A
K
-
E
-
Q
T
-------------
Q
I
L
A
E
V
-
A
E
-------
G
-
K
I
D
I
L
I
G
T
H
K
L
L
Q
S
D
V
KFKDLG
L
L
I
V
D
E
E
H
R
F
G
V
R
H
K
E
R
--------
I
--
K
A
M
R
A
-
N
V
D
I
L
T
L
T
A
T
P
IP
R
T
L
N
M
A
M
S
G
M
R
D
L
S
I
I
A
T
P
P
A
R
R
L
A
V
K
T
F
V
R
E
YD
S
M
V
V
R
E
A
I
L
R
E
----
I
L
R
G
G
Q
V
Y
Y
L
Y
N
-------
D
V
E
N
I
Q
K
------
A
-
A
------
E
R
-
L
A
E
L
V
P
----------
E
A
R
I
--
A
---
I
G
--------
H
G
---
Q
----
M
R
---
E
R
E
-
L
E
R
V
M
N
D
F
H
H
Q
-------
R
F
--------
N
V
--------
L
V
C
TT
I
---
I
E
T
G
---
I
D
I
P
TA-----------
N
T
I
I
I
E
R
A
D
H
F
G
L
A
Q
L
H
Q
L
R
G
------
R
V
G
-------------------
R
--------
S
H
H
Q
A
Y
A
W
L
L
T
P
H
P
K
A
M
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
---
E
D
L
G
A
G
F
A
L
A
T
H
D
L
E
I
R
G
--
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
I
G
F
S
L
Y
M
E
L
L
E
N
A
V
D
A
L
K
A
G
R
E
P
S
----------
L
E
D
L
T
S
Q
Q
T
E
-
V
-
E
L
R
M
P
S
L
L
P
D
D
F
I
P
D
V
N
T
R
L
S
F
Y
K
R
--
I
A
S
--
A
K
T
-
E
N
E
L
E
E
I
K
V
---
E
L
I
D
R
F
G
LL
P
D
P
A
R
T
L
L
-
D
I
A
R
L
R
Q
Q
A
Q
K
L
G
I
R
K
L
E
G
N
E
K
G
G
V
I
E
F
A
E
K
N
H
V
N
P
A
W
L
I
G
L
L
Q
K
Q
P
Q
H
Y
R
L
D
G
P
T
R
L
K
F
I
Q
D
-------------------------------
L
S
E
R
K
T
R
I
E
W
V
R
Q
F
M
R
E
L
E
E
N
A
I
-
40
HHSearch
34.17
20%
5
- C6 -
-
3LFU
-
UVRD_ECOLI
A:
[171-618]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
Y
Q
A
Y
Q
E
A
C
D
R
A
G
L
V
D
F
A
E
L
L
L
R
A
H
E
L
W
L
N
K
---------
P
H
I
L
Q
H
Y
R
E
R
F
T
N
I
L
V
D
E
F
Q
D
T
N
N
I
Q
Y
A
W
I
R
L
L
A
G
D
-
T
------------
G
K
V
M
I
V
G
D
D
D
Q
S
I
Y
G
W
R
G
A
Q
V
E
N
I
Q
R
F
L
N
D
F
P
-----
G
---
A
E
T
I
R
L
E
Q
N
Y
R
S
T
S
N
I
L
S
A
A
N
A
L
I
E
N
-------
N
-
N
--
G
--
R
-
L
----
G
K
-----
K
L
-----
W
T
D
G
A
---------------
D
G
---
E
P
I
S
L
Y
--------
C
A
F
N
E
-------
L
---------
D
E
A
R
F
V
V
N
R
I
K
T
W
Q
D
---------------
N
G
G
A
L
A
E
C
A
I
L
Y
R
-
S
N
A
Q
S
R
V
L
E
E
A
L
L
-
Q
A
S
M
-
P
Y
R
I
Y
----
G
-
G
M
R
F
F
E
R
Q
E
I
K
D
A
L
S
Y
L
R
L
I
A
N
R
N
D
D
A
A
F
E
R
V
V
-----------
N
T
---
P
T
R
G
I
G
D
R
T
L
--
D
V
V
R
Q
T
S
R
D
R
QL
T
-
L
W
Q
A
----------------
C
-----------------
R
E
L
L
Q
E
KALA
G
R
A
A
S
A
L
Q
R
F
----------------
M
E
-
L
---
I
D
A
L
A
Q
E
T
A
---
D
M
P
L
H
V
Q
T
D
R
V
I
K
D
S
G
----
L
R
T
M
Y
E
Q
E
--
K
G
E
K
-------
G
Q
-
T
R
I
E
N
----------
L
E
E
L
V
T
A
T
R
--
Q
F
-
S
-----------
E
D
L
M
P
-------------
L
Q
A
F
--
L
S
H
-
A
A
L
---
E
--------
G
E
-------------
G
Q
A
D
T
W
-
Q
D
-------
A
-
V
Q
L
M
T
L
H
S
A
K
G
L
E
F
P
Q
------
V
F
I
V
G
M
E
E
G
-----
M
F
P
--------
S
---
Q
M
S
-------------------------------------
L
--
G
G
R
L
E
E
E
--
R
R
L
A
Y
V
G
V
T
R
A
----
M
Q
K
---
L
T
L
T
Y
A
-------
E
T
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
32.39
47%
-209
- C7 -
-
1QHH
1
?
D:
[3-36]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
------
V
F
L
I
G
M
E
E
G
I
----
F
P
H
--------
N
--
R
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
31.05
23%
-11
- C6 -
-
1QHG
1
PCRA_GEOSE
A:
[212-591]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
----
A
E
R
F
Q
-------
N
I
C
A
--
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
--
P
---
N
---
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
-------
N
-
V
--
N
----------------------------
R
---
K
P
--
K
--
R
I
W
T
E
N
P
E
G
K
P
I
-
L
Y
--------
Y
E
A
M
N
-------
E
--------
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
---
G
E
R
R
Y
R
-----------
D
F
A
V
L
Y
R
-
T
-
N
A
Q
S
R
V
---
M
E
-
E
M
L
L
-
K
A
N
I
P
Y
Q
I
V
G
-
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
NVPKRGIGAST
I
D
-----------------
L
F
E
A
L
-----
G
-
E
L
E
M
----------------
I
-----------------
G
L
----------------
G
A
----------------
K
A
-
A
---
G
A
L
A
----
A
---
F
R
S
Q
L
E
Q
W
T
Q
L
Q
E
Y
V
S
----
V
T
E
L
V
E
E
V
--
L
D
K
S
-------
G
Y
-
R
E
M
L
K
A
E
RT
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
V
T
K
H
-
F
E
-----
N
---
V
S
D
D
K
S
-------------
L
I
A
F
--
L
T
D
L
A
L
I
---
S
------------------------------
G
D
-------
A
-
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
------
V
F
L
I
G
M
E
E
G
I
----
F
P
H
--------
N
--
R
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
30.50
23%
-10
- C6 -
-
1PJR
-
PCRA_GEOSE
A:
[212-591]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
----
A
E
R
F
Q
-------
N
I
C
A
--
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
--
P
---
N
---
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
-------
N
-
V
--
N
----------------------------
R
---
K
P
--
K
--
R
I
W
T
E
N
P
E
G
K
P
I
-
L
Y
--------
Y
E
A
M
N
-------
E
--------
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
---
G
E
R
R
Y
R
-----------
D
F
A
V
L
Y
R
-
T
-
N
A
Q
S
R
V
---
M
E
-
E
M
L
L
-
K
A
N
I
P
Y
Q
I
V
G
-
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
NVPKRGIGAST
I
D
-----------------
L
F
E
A
L
-----
G
-
E
L
E
M
----------------
I
-----------------
G
L
----------------
G
A
----------------
K
A
-
A
---
G
A
L
A
----
A
---
F
R
S
Q
L
E
Q
W
T
Q
L
Q
E
Y
V
S
----
V
T
E
L
V
E
E
V
--
L
D
K
S
-------
G
Y
-
R
E
M
L
K
A
E
RT
I
E
A
Q
S
R
L
E
N
L
D
E
F
L
S
V
T
K
H
-
F
E
-----
N
---
V
S
D
D
K
S
-------------
L
I
A
F
--
L
T
D
L
A
L
I
---
S
------------------------------
G
D
-------
A
-
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
------
V
F
L
I
G
M
E
E
G
I
----
F
P
H
--------
N
--
R
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
30.42
23%
-3
- C6 -
-
3PJR
2
?
A:
[212-591]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
Q
Y
K
F
Q
Y
I
H
I
D
E
Y
Q
D
T
N
R
A
Q
Y
T
L
V
K
K
L
----
A
E
R
F
Q
-------
N
I
C
A
--
V
G
D
A
D
Q
S
I
Y
R
W
R
G
A
D
I
Q
N
I
L
S
F
E
R
D
Y
--
P
---
N
---
A
K
V
I
L
L
E
Q
N
Y
R
S
T
K
R
I
L
Q
A
A
N
E
V
I
E
H
-------
N
-
V
--
N
----------------------------
R
---
K
P
--
K
--
R
I
W
T
E
N
P
E
G
K
P
I
-
L
Y
--------
Y
E
A
M
N
-------
E
--------
A
D
E
A
Q
F
V
A
G
R
I
R
E
A
V
E
R
---
G
E
R
R
Y
R
-----------
D
F
A
V
L
Y
R
-
T
-
N
A
Q
S
R
V
---
M
E
-
E
M
L
L
-
K
A
N
I
P
Y
Q
I
V
G
-
G
L
K
F
Y
D
R
K
E
I
K
D
I
L
A
Y
L
R
V
I
A
N
P
D
D
D
L
S
L
L
R
I
I
NVPKRGIGA
S
T
I
D
---
K
L
V
R
Y
A
A
D
H
E
--
L
S
L
F
E
A
L
-----
G
-
E
L
E
M
----------------
I
-----------------
G
L
----------------
G
A
----------------
K
A
-
A
---
G
A
L
A
----
A
---
F
R
S
Q
L
E
Q
W
T
Q
L
Q
E
Y
V
S
----
V
T
E
L
V
E
E
V
--
L
D
K
S
-------
G
Y
-
R
E
M
L
K
AERTIEA
Q
S
R
L
E
N
L
D
E
F
L
S
V
T
K
H
-
F
E
-----
N
---
V
S
D
D
K
S
-------------
L
I
A
F
--
L
T
D
L
A
L
I
---
S
D
L
D
-
E
------------------
T
E
Q
A
A
E
-
G
D
-------
A
-
V
M
L
M
T
L
H
A
A
K
G
L
E
F
P
V
------
V
F
L
I
G
M
E
E
G
I
----
F
P
H
--------
N
--
R
S
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
29.71
23%
-17
- C6 -
-
1UAA
1
REP_ECOLI
A:
[205-577]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
K
I
R
Y
L
L
V
D
E
Y
Q
D
T
N
T
S
Q
Y
E
L
V
K
L
L
V
G
S
-
R
A
R
F
------------
T
V
V
G
D
D
D
Q
S
I
Y
S
W
R
G
A
R
P
Q
N
L
V
L
L
S
Q
D
F
P
A
L
--------
K
V
I
K
L
E
Q
N
Y
R
S
S
G
R
I
L
K
A
A
N
I
L
I
A
N
-------
N
-
P
--
H
--
V
-
F
E
K
R
L
F
S
-----
E
L
-----
G
Y
G
A
E
----------------------
L
-
K
V
--------
L
S
A
N
N
-------
E
--------
E
H
E
A
E
R
V
T
G
E
L
-----
I
A
H
----
H
F
V
N
K
T
Q
Y
K
-----
D
Y
A
I
L
Y
R
G
N
H
Q
S
R
V
F
E
K
F
L
M
Q
N
R
I
P
Y
-
K
I
S
G
G
----
T
---
S
F
F
S
R
P
E
I
K
D
L
L
A
Y
L
R
V
L
T
N
P
D
D
D
S
A
F
L
R
I
V
-----------
N
T
PKR
E
I
G
P
A
T
L
K
K
L
--
G
E
W
A
M
T
------
R
-
N
K
S
M
----------------
F
-----------------
T
A
----------------
S
F
----------------
D
M
G
L
---
S
Q
T
L
----
S
---
G
R
G
Y
-----
E
A
L
T
R
F
T
----
H
W
--
L
A
E
I
--
Q
R
L
A
-------
E
R
-
E
P
I
A
A
----------
V
R
D
L
I
H
G
M
D
--
Y
E
-
S
W
-----
L
---
Y
E
T
S
P
S
P
K
A
A
E
M
R
M
K
N
V
N
Q
L
F
S
W
--
M
T
E
-
M
L
E
G--
S
E
L
D
E
P
-
M
-
T
L
T
Q
V
V
T
R
F
T
L
RDMM
E
R
---
E
-
E
E
LD-----
Q
-
V
Q
L
M
T
L
H
A
S
K
G
L
E
F
P
Y
------
V
Y
M
V
G
M
E
E
G
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------