@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLS4: (2017-11-04 )
MSEQQPKFEIRDEEQLSVDLIEAQYALKESRGKPNAKSTLILMSGIELAGKGEAVKQLREWLDPRYLRVKADAPRVLTDSEAFWQSYSAFIPTEGQIVVMFGNWYSDLLVTATHVSEPLDDARFDAYVENMRAFEQDLKNNYVDVIKVWFDLSWKSLQKRLDKIDPSEQHWHKLHGLDWRNKKQYDTLQKLRRRFTDDWYIIDGEDEKQRDQFFAQYLLQHMRQLPEHETEVKGKWQQAKIPESLLKPAQEKMDKAEYKKELDKLSKKIADTMRFDKRNVVIAFEGMDAAGKGGAIKRIVKNLDPREYDIHCIGAPERFEARHPYLWRFWNRINEAEKITIFDRTWYGRVLVERVEGFASPIEWQRAYDEINSFEKDLFDSQTIVVKIWLAISKDEQEQRFKAREETPHKRFKITAEDWRNRDKWDDYLKAAADMFERTSTEYAPWYIVATDDKYTARLEVLRAILKQLRAD
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70-----..-......80........90........100.......110.......120.......130.......140.......150.......160.......170.......180......----.190...-------...---.200.......210.......220.......230.......240....--...-------250.......260.......270---.---.---.-.----...280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSEQQPKFEIRD
E
E
QL
S
V
D
L
I
E
A
Q
Y
A
L
K
ESRGKPNA
K
S
T
L
I
L
M
SGIELAGK
G
E
A
V
K
Q
L
R
E
WLDP
R
Y
L
R
V
KA-----DA-PRVLTD
S
E
A
F
W
Q
S
Y
S
A
FIPTE
G
Q
I
V
V
M
FGNW
Y
S
D
L
L
V
T
A
THVSEP
L
D
D
A
R
F
D
A
Y
V
E
N
M
R
A
F
E
Q
D
L
K
N
N
Y
V
D
V
I
K
V
W
F
DL
S
W
K
S
L
Q
K
R
L
DKIDP
S
E
Q
H
W
H
K
LHGLDWRNKK
Q
Y
D
T
L
----
Q
K
L
R
R
RF-------TD
D
---
W
Y
I
IDGE
D
E
K
Q
R
D
Q
F
F
A
Q
Y
L
L
Q
H
M
R
QLPE
H
E
T
E
VKGK
W
Q
QAKI
P
E
S
L
L
--
K
P
A
-------
Q
E
K
M
D
K
A
E
Y
K
K
E
L
D
K
L
S
K
K
I
A
D
T
---M---R---F-D----KR
N
V
V
I
A
F
EGMDAAGK
G
G
A
I
K
R
I
V
K
NLDPR
E
Y
D
I
H
C
IGAPERFEARH
P
Y
L
W
R
F
W
N
RINEA
E
K
I
T
I
FDRT
W
Y
G
R
V
L
V
E
R
V
E
G
FAS
P
I
E
W
Q
R
A
Y
D
E
I
N
S
F
E
K
D
LFDS
Q
T
I
V
V
K
I
W
L
A
ISK
D
E
Q
E
Q
R
F
K
A
REETPHK
R
F
K
I
T
A
E
D
WRN
R
D
K
W
D
D
Y
L
K
A
A
A
D
M
F
E
RTSTEYA
P
W
Y
I
V
ATDD
K
Y
T
A
R
L
E
V
L
R
A
I
L
K
Q
LRAD
31
HHSearch
82.68
42%
8
- C5 -
-
3CZP
6
?
A:
[15-492]
-----
K
D
T
Y
E
K
A
V
I
E
L
R
E
A
L
L
E
A
Q
F
E
L
K
Q
Q
A
R
F
----
P
V
I
I
L
I
N
G
I
E
G
A
G
K
G
E
T
V
K
L
L
N
E
W
M
D
P
R
L
I
E
V
Q
S
-----
F
L
R
P
S
D
E
E
L
E
R
P
P
Q
W
R
F
W
R
R
L
P
P
K
G
R
T
G
I
F
F
G
N
W
Y
S
Q
M
L
Y
A
R
V
E
G
H
--
I
K
E
A
K
L
D
Q
A
I
D
A
A
E
R
F
E
R
M
L
C
D
E
G
A
L
L
F
K
F
W
F
H
L
S
K
K
Q
L
K
E
R
-------------
L
S
P
L
D
W
K
Q
S
E
V
Y
D
R
F
----
V
H
Y
G
E
R
V
L
R
R
T
SRD
Y
A
P
---
W
Y
V
V
E
G
A
D
E
R
Y
R
A
L
T
V
G
R
I
L
L
E
G
L
Q
A
A
L
A
T
------------
D
N
R
G
L
L
D
S
L
D
L
-------
G
Q
Y
L
D
K
D
A
Y
K
E
Q
L
A
A
E
Q
A
R
L
A
G
L
---
I
---
R
DKR
F
-
R
----
Q
H
S
L
V
A
V
F
E
G
N
D
A
A
G
K
G
G
A
I
R
R
V
T
D
A
L
D
P
R
Q
Y
H
I
V
P
I
A
A
P
T
E
E
E
R
A
Q
P
Y
L
W
R
F
W
R
H
I
P
A
R
R
Q
F
T
I
F
D
R
S
W
Y
G
R
V
L
V
E
R
I
E
G
F
C
A
P
A
D
W
L
R
A
Y
G
E
I
N
D
F
E
E
Q
L
S
E
Y
G
I
I
V
V
K
F
W
L
A
I
D
K
Q
T
Q
M
E
R
F
K
E
R
E
K
T
P
Y
K
R
Y
K
I
T
E
E
D
W
R
N
R
D
K
W
D
Q
Y
V
D
A
V
G
D
M
V
D
R
T
S
T
E
I
A
P
W
T
L
V
E
A
N
D
K
R
F
A
R
V
K
V
L
R
T
I
N
D
A
I
E
A
-
1
PsiBlast_PDB
80.85
41%
27
- C5 -
-
3CZP
6
?
A:
[24-486]
--------------
E
L
R
E
A
L
L
E
A
Q
F
E
L
K
Q
Q
A
R
F
P
----
V
I
I
L
I
N
G
I
E
G
A
G
K
G
E
T
V
K
L
L
N
E
W
M
D
P
R
L
I
E
V
Q
S
F
LRPS
D
E
-
E
L
E
R
P
P
Q
W
R
F
W
R
R
----
L
P
P
K
G
R
T
G
I
F
F
G
N
W
Y
S
Q
M
L
Y
A
--
R
V
E
G
H
I
K
E
A
K
L
D
Q
A
I
D
A
A
E
R
F
E
R
M
L
C
D
E
G
A
L
L
F
K
F
W
F
H
L
S
K
K
Q
L
K
E
R
-------------
L
S
P
L
D
W
K
Q
S
E
V
Y
D
R
F
V
H
Y
G
E
R
V
L
R
R
T
-------
S
R
D
Y
A
P
W
Y
V
V
E
G
A
D
E
R
Y
R
A
L
T
V
G
R
I
L
L
E
G
L
Q
A
A
L
A
T
-----------------
D
--
N
R
G
L
L
D
S
LDL
G
Q
Y
L
D
K
D
A
Y
K
E
Q
L
A
A
E
Q
A
R
L
A
G
L
---
I
---
R
DKR
F
-
R
----
Q
H
S
L
V
A
V
F
E
G
N
D
A
A
G
K
G
G
A
I
R
R
V
T
D
A
L
D
P
R
Q
Y
H
I
V
P
I
A
A
P
T
E
E
E
R
A
Q
P
Y
L
W
R
F
W
R
H
I
P
A
R
R
Q
F
T
I
F
D
R
S
W
Y
G
R
V
L
V
E
R
I
E
G
F
C
A
P
A
D
W
L
R
A
Y
G
E
I
N
D
F
E
E
Q
L
S
E
Y
G
I
I
V
V
K
F
W
L
A
I
D
K
Q
T
Q
M
E
R
F
K
E
R
E
K
T
P
Y
K
R
Y
K
I
T
E
E
D
W
R
N
R
D
K
W
D
Q
Y
V
D
A
V
G
D
M
V
D
R
T
S
T
E
I
A
P
W
T
L
V
E
A
N
D
K
R
F
A
R
V
K
V
L
R
T
I
-------
39
HHSearch
58.59
32%
-17
* C5 *
-
5LC9
-
?
B:
[48-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
Q
A
A
L
E
A
L
A
V
L
N
R
R
L
E
K
L
---
Q
---
E
---
L
-
L
YAEG
Q
H
K
V
L
V
V
L
Q
A
M
D
A
G
G
K
D
G
T
I
R
V
V
F
D
G
V
N
P
S
G
V
R
V
A
S
F
G
V
P
T
E
Q
E
L
A
R
D
Y
L
W
R
V
H
Q
Q
V
P
R
K
G
E
L
V
I
F
N
R
S
H
Y
E
D
V
L
V
V
R
V
K
N
L
V
P
Q
Q
V
W
Q
K
R
Y
R
H
I
R
E
F
E
R
M
L
A
D
E
G
T
T
I
L
K
F
F
L
H
I
S
K
D
E
Q
R
Q
R
L
Q
E
R
L
D
N
P
E
K
R
W
K
F
R
M
G
D
L
E
D
R
R
L
W
D
R
Y
Q
E
A
Y
E
A
A
I
R
E
T
S
T
E
Y
A
P
W
Y
V
I
P
A
N
K
N
W
Y
R
N
W
L
V
S
H
I
L
V
E
T
L
E
G
-
38
HHSearch
57.65
32%
-15
- C5 -
-
5LD1
4
?
C:
[48-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
Q
A
A
L
E
A
L
A
V
L
N
R
R
L
E
K
L
---
Q
---
E
---
L
-
L
YAEG
Q
H
K
V
L
V
V
L
Q
A
M
D
A
G
G
K
D
G
T
I
R
V
V
F
D
G
V
N
P
S
G
V
R
V
A
S
F
G
V
P
T
E
Q
E
L
A
R
D
Y
L
W
R
V
H
Q
Q
V
P
R
K
G
E
L
V
I
F
N
R
S
H
Y
E
D
V
L
V
V
R
V
K
N
L
V
P
Q
Q
V
W
Q
K
R
Y
R
H
I
R
E
F
E
R
M
L
A
D
E
G
T
T
I
L
K
F
F
L
H
I
S
K
D
E
Q
R
Q
R
L
Q
E
R
L
D
N
P
E
K
R
W
K
F
R
M
G
D
L
E
D
R
R
L
W
D
R
Y
Q
E
A
Y
E
A
A
I
R
E
T
S
T
E
Y
A
P
W
Y
V
I
P
A
N
K
N
W
Y
R
N
W
L
V
S
H
I
L
V
E
T
L
E
G
-
25
PsiBlast_CBE
55.79
36%
-110
- C5 -
-
5LD1
4
?
C:
[78-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
V
L
Q
A
M
D
A
G
G
K
D
G
T
I
R
V
V
F
D
G
V
N
P
S
G
V
R
V
A
S
F
G
V
P
T
E
Q
E
L
A
R
D
Y
L
W
R
V
H
Q
Q
V
P
R
K
G
E
L
V
I
F
N
R
S
H
Y
E
D
V
L
V
V
R
V
K
N
L
V
P
Q
Q
V
W
Q
K
R
Y
R
H
I
R
E
F
E
R
M
L
A
D
E
G
T
T
I
L
K
F
F
L
H
I
S
K
D
E
Q
R
Q
R
L
Q
E
R
L
D
N
P
E
K
R
W
K
F
R
M
G
D
L
E
D
R
R
L
W
D
R
Y
Q
E
A
Y
E
A
A
I
R
E
T
S
T
E
Y
A
P
W
Y
V
I
P
A
N
--------------------
7
PsiBlast_PDB
55.63
36%
-110
- C5 -
-
5LD1
3
?
A:
[78-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
V
L
Q
A
M
D
A
G
G
K
D
G
T
I
R
V
V
F
D
G
V
N
P
S
G
V
R
V
A
S
F
G
V
P
T
E
Q
E
L
A
R
D
Y
L
W
R
V
H
Q
Q
V
P
R
K
G
E
L
V
I
F
N
R
S
H
Y
E
D
V
L
V
V
R
V
K
N
L
V
P
Q
Q
V
W
Q
K
R
Y
R
H
I
R
E
F
E
R
M
L
A
D
E
G
T
T
I
L
K
F
F
L
H
I
S
K
D
E
Q
R
Q
R
L
Q
E
R
L
D
N
P
E
K
R
W
K
F
R
M
G
D
L
E
D
R
R
L
W
D
R
Y
Q
E
A
Y
E
A
A
I
R
E
T
S
T
E
Y
A
P
W
Y
V
I
P
A
N
--------------------
24
PsiBlast_CBE
55.50
36%
-111
- C5 -
-
5LD1
3
?
D:
[78-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
V
L
Q
A
M
D
A
G
G
K
D
G
T
I
R
V
V
F
D
G
V
N
P
S
G
V
R
V
A
S
F
G
V
P
T
E
Q
E
L
A
R
D
Y
L
W
R
V
H
Q
Q
V
P
R
K
G
E
L
V
I
F
N
R
S
H
Y
E
D
V
L
V
V
R
V
K
N
L
V
P
Q
Q
V
W
Q
K
R
Y
R
H
I
R
E
F
E
R
M
L
A
D
E
G
T
T
I
L
K
F
F
L
H
I
S
K
D
E
Q
R
Q
R
L
Q
E
R
L
D
N
P
E
K
R
W
K
F
R
M
G
D
L
E
D
R
R
L
W
D
R
Y
Q
E
A
Y
E
A
A
I
R
E
T
S
T
E
Y
A
P
W
Y
V
I
P
A
N
--------------------
26
PsiBlast_CBE
55.36
36%
-107
- C5 -
-
5LD1
4
?
B:
[78-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
V
L
Q
A
M
D
A
G
G
K
D
G
T
I
R
V
V
F
D
G
V
N
P
S
G
V
R
V
A
S
F
G
V
P
T
E
Q
E
L
A
R
D
Y
L
W
R
V
H
Q
Q
V
P
R
K
G
E
L
V
I
F
N
R
S
H
Y
E
D
V
L
V
V
R
V
K
N
L
V
P
Q
Q
V
W
Q
K
R
Y
R
H
I
R
E
F
E
R
M
L
A
D
E
G
T
T
I
L
K
F
F
L
H
I
S
K
D
E
Q
R
Q
R
L
Q
E
R
L
D
N
P
E
K
R
W
K
F
R
M
G
D
L
E
D
R
R
L
W
D
R
Y
Q
E
A
Y
E
A
A
I
R
E
T
S
T
E
Y
A
P
W
Y
V
I
P
A
N
--------------------
3
PsiBlast_PDB
54.42
37%
-31
- C5 -
-
3RHF
1
?
A:
[57-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
L
Q
E
K
L
F
A
E
---
G
---
K
---
F
G
N
----
P
K
R
L
L
L
I
L
Q
A
M
D
T
A
G
K
G
G
I
V
S
H
V
V
G
A
M
D
P
Q
G
V
Q
L
T
A
F
K
A
P
T
D
E
E
K
S
H
D
F
L
W
R
I
E
K
Q
V
P
A
A
G
M
V
G
V
F
D
R
S
Q
Y
E
D
V
L
I
H
R
V
H
G
W
A
D
A
A
E
L
E
R
R
Y
A
A
I
N
D
F
E
S
R
L
T
E
Q
G
T
T
I
V
K
V
M
L
N
I
S
K
D
E
Q
K
K
R
L
I
A
R
L
D
D
P
S
K
H
W
K
Y
S
R
G
D
L
A
E
R
A
Y
W
D
D
Y
M
D
A
Y
S
V
A
F
E
K
T
S
T
E
I
A
P
W
H
V
V
P
A
N
K
K
W
Y
A
R
I
A
V
Q
Q
L
L
L
D
A
L
---
37
HHSearch
54.32
20%
-30
- C5 -
-
3RHF
1
?
A:
[43-269]
-----
K
A
D
G
K
A
L
L
A
A
Q
D
A
R
L
A
E
L
Q
E
K
L
F
A
E
G
K
F
G
N
P
K
R
L
L
L
I
L
Q
A
M
D
T
A
G
K
G
G
I
V
S
H
V
V
G
A
M
D
P
Q
G
V
Q
L
T
A
-----
F
K
A
P
T
D
E
E
K
S
H
D
F
L
W
R
I
E
K
Q
V
P
A
A
G
M
V
G
V
F
D
R
S
Q
Y
E
D
V
L
I
H
R
V
H
G
W
--
A
D
A
A
E
L
E
R
R
Y
A
A
I
N
D
F
E
S
R
L
T
E
Q
G
T
T
I
V
K
V
M
L
N
I
S
K
D
E
Q
K
K
R
L
I
A
R
L
D
D
P
S
K
H
W
K
Y
S
R
G
D
L
A
E
R
A
Y
W
D
D
Y
----
M
D
A
Y
S
V
A
F
E
K
TSTE
I
A
P
---
W
H
V
V
P
A
N
K
K
W
Y
A
R
I
A
V
Q
Q
L
L
L
D
A
L
G
G
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
54.31
36%
-96
- C5 -
-
5LCD
1
?
C:
[78-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
V
L
Q
A
M
D
A
G
G
K
D
G
T
I
R
V
V
F
D
G
V
N
P
S
G
V
R
V
A
S
F
G
V
P
T
E
Q
E
L
A
R
D
Y
L
W
R
V
H
Q
Q
V
P
R
K
G
E
L
V
I
F
N
R
S
H
Y
E
D
V
L
V
V
R
V
K
N
L
V
P
Q
Q
V
W
Q
K
R
Y
R
H
I
R
E
F
E
R
M
L
A
D
E
G
T
T
I
L
K
F
F
L
H
I
S
K
D
E
Q
R
Q
R
L
Q
E
R
L
D
N
P
E
K
R
W
K
F
R
M
G
D
L
E
D
R
R
L
W
D
R
Y
Q
E
A
Y
E
A
A
I
R
E
T
S
T
E
Y
A
P
W
Y
V
I
P
A
N
--------------------
5
PsiBlast_PDB
54.24
36%
-104
- C5 -
-
5LC9
-
?
A:
[78-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
V
L
Q
A
M
D
A
G
G
K
D
G
T
I
R
V
V
F
D
G
V
N
P
S
G
V
R
V
A
S
F
G
V
P
T
E
Q
E
L
A
R
D
Y
L
W
R
V
H
Q
Q
V
P
R
K
G
E
L
V
I
F
N
R
S
H
Y
E
D
V
L
V
V
R
V
K
N
L
V
P
Q
Q
V
W
Q
K
R
Y
R
H
I
R
E
F
E
R
M
L
A
D
E
G
T
T
I
L
K
F
F
L
H
I
S
K
D
E
Q
R
Q
R
L
Q
E
R
L
D
N
P
E
K
R
W
K
F
R
M
G
D
L
E
D
R
R
L
W
D
R
Y
Q
E
A
Y
E
A
A
I
R
E
T
S
T
E
Y
A
P
W
Y
V
I
P
A
N
--------------------
21
PsiBlast_CBE
53.93
36%
-106
- C5 -
-
5LDB
1
?
D:
[78-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
V
L
Q
A
M
D
A
G
G
K
D
G
T
I
R
V
V
F
D
G
V
N
P
S
G
V
R
V
A
S
F
G
V
P
T
E
Q
E
L
A
R
D
Y
L
W
R
V
H
Q
Q
V
P
R
K
G
E
L
V
I
F
N
R
S
H
Y
E
D
V
L
V
V
R
V
K
N
L
V
P
Q
Q
V
W
Q
K
R
Y
R
H
I
R
E
F
E
R
M
L
A
D
E
G
T
T
I
L
K
F
F
L
H
I
S
K
D
E
Q
R
Q
R
L
Q
E
R
L
D
N
P
E
K
R
W
K
F
R
M
G
D
L
E
D
R
R
L
W
D
R
Y
Q
E
A
Y
E
A
A
I
R
E
T
S
T
E
Y
A
P
W
Y
V
I
P
A
N
--------------------
27
PsiBlast_CBE
53.85
36%
-99
- C5 -
-
5LCD
1
?
D:
[78-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
V
L
Q
A
M
D
A
G
G
K
D
G
T
I
R
V
V
F
D
G
V
N
P
S
G
V
R
V
A
S
F
G
V
P
T
E
Q
E
L
A
R
D
Y
L
W
R
V
H
Q
Q
V
P
R
K
G
E
L
V
I
F
N
R
S
H
Y
E
D
V
L
V
V
R
V
K
N
L
V
P
Q
Q
V
W
Q
K
R
Y
R
H
I
R
E
F
E
R
M
L
A
D
E
G
T
T
I
L
K
F
F
L
H
I
S
K
D
E
Q
R
Q
R
L
Q
E
R
L
D
N
P
E
K
R
W
K
F
R
M
G
D
L
E
D
R
R
L
W
D
R
Y
Q
E
A
Y
E
A
A
I
R
E
T
S
T
E
Y
A
P
W
Y
V
I
P
A
N
--------------------
6
PsiBlast_PDB
53.38
36%
-98
- C5 -
-
5LCD
1
?
A:
[78-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
V
L
Q
A
M
D
A
G
G
K
D
G
T
I
R
V
V
F
D
G
V
N
P
S
G
V
R
V
A
S
F
G
V
P
T
E
Q
E
L
A
R
D
Y
L
W
R
V
H
Q
Q
V
P
R
K
G
E
L
V
I
F
N
R
S
H
Y
E
D
V
L
V
V
R
V
K
N
L
V
P
Q
Q
V
W
Q
K
R
Y
R
H
I
R
E
F
E
R
M
L
A
D
E
G
T
T
I
L
K
F
F
L
H
I
S
K
D
E
Q
R
Q
R
L
Q
E
R
L
D
N
P
E
K
R
W
K
F
R
M
G
D
L
E
D
R
R
L
W
D
R
Y
Q
E
A
Y
E
A
A
I
R
E
T
S
T
E
Y
A
P
W
Y
V
I
P
A
N
--------------------
29
PsiBlast_CBE
53.37
36%
-99
- C5 -
-
5LCD
1
?
B:
[78-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
V
L
Q
A
M
D
A
G
G
K
D
G
T
I
R
V
V
F
D
G
V
N
P
S
G
V
R
V
A
S
F
G
V
P
T
E
Q
E
L
A
R
D
Y
L
W
R
V
H
Q
Q
V
P
R
K
G
E
L
V
I
F
N
R
S
H
Y
E
D
V
L
V
V
R
V
K
N
L
V
P
Q
Q
V
W
Q
K
R
Y
R
H
I
R
E
F
E
R
M
L
A
D
E
G
T
T
I
L
K
F
F
L
H
I
S
K
D
E
Q
R
Q
R
L
Q
E
R
L
D
N
P
E
K
R
W
K
F
R
M
G
D
L
E
D
R
R
L
W
D
R
Y
Q
E
A
Y
E
A
A
I
R
E
T
S
T
E
Y
A
P
W
Y
V
I
P
A
N
--------------------
23
PsiBlast_CBE
53.23
36%
-103
- C5 -
-
5LDB
1
?
B:
[78-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
V
L
Q
A
M
D
A
G
G
K
D
G
T
I
R
V
V
F
D
G
V
N
P
S
G
V
R
V
A
S
F
G
V
P
T
E
Q
E
L
A
R
D
Y
L
W
R
V
H
Q
Q
V
P
R
K
G
E
L
V
I
F
N
R
S
H
Y
E
D
V
L
V
V
R
V
K
N
L
V
P
Q
Q
V
W
Q
K
R
Y
R
H
I
R
E
F
E
R
M
L
A
D
E
G
T
T
I
L
K
F
F
L
H
I
S
K
D
E
Q
R
Q
R
L
Q
E
R
L
D
N
P
E
K
R
W
K
F
R
M
G
D
L
E
D
R
R
L
W
D
R
Y
Q
E
A
Y
E
A
A
I
R
E
T
S
T
E
Y
A
P
W
Y
V
I
P
A
N
--------------------
22
PsiBlast_CBE
53.18
36%
-102
- C5 -
-
5LDB
1
?
C:
[78-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
V
L
Q
A
M
D
A
G
G
K
D
G
T
I
R
V
V
F
D
G
V
N
P
S
G
V
R
V
A
S
F
G
V
P
T
E
Q
E
L
A
R
D
Y
L
W
R
V
H
Q
Q
V
P
R
K
G
E
L
V
I
F
N
R
S
H
Y
E
D
V
L
V
V
R
V
K
N
L
V
P
Q
Q
V
W
Q
K
R
Y
R
H
I
R
E
F
E
R
M
L
A
D
E
G
T
T
I
L
K
F
F
L
H
I
S
K
D
E
Q
R
Q
R
L
Q
E
R
L
D
N
P
E
K
R
W
K
F
R
M
G
D
L
E
D
R
R
L
W
D
R
Y
Q
E
A
Y
E
A
A
I
R
E
T
S
T
E
Y
A
P
W
Y
V
I
P
A
N
--------------------
8
PsiBlast_PDB
53.11
36%
-104
- C5 -
-
5LDB
2
?
A:
[78-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
V
L
Q
A
M
D
A
G
G
K
D
G
T
I
R
V
V
F
D
G
V
N
P
S
G
V
R
V
A
S
F
G
V
P
T
E
Q
E
L
A
R
D
Y
L
W
R
V
H
Q
Q
V
P
R
K
G
E
L
V
I
F
N
R
S
H
Y
E
D
V
L
V
V
R
V
K
N
L
V
P
Q
Q
V
W
Q
K
R
Y
R
H
I
R
E
F
E
R
M
L
A
D
E
G
T
T
I
L
K
F
F
L
H
I
S
K
D
E
Q
R
Q
R
L
Q
E
R
L
D
N
P
E
K
R
W
K
F
R
M
G
D
L
E
D
R
R
L
W
D
R
Y
Q
E
A
Y
E
A
A
I
R
E
T
S
T
E
Y
A
P
W
Y
V
I
P
A
N
--------------------
32
HHSearch
52.60
33%
31
- C5 -
-
3CZQ
1
?
C:
[54-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
K
L
D
R
E
E
Y
E
E
T
L
T
K
L
Q
I
E
L
V
K
V
Q
F
W
M
---
Q
---
A
-
T
----
G
K
R
V
M
A
V
F
E
G
R
D
A
A
G
K
G
G
A
I
H
A
T
T
A
N
M
N
P
R
S
A
R
V
V
A
L
T
K
P
T
E
T
E
R
G
Q
W
Y
F
Q
R
Y
V
A
T
F
P
T
A
G
E
F
V
L
F
D
R
S
W
Y
N
R
A
G
V
E
P
V
M
G
F
C
T
P
D
Q
Y
E
Q
F
L
K
E
A
P
R
F
E
E
M
I
A
N
E
G
I
H
L
F
K
F
W
I
N
I
G
R
E
M
Q
L
K
R
F
H
D
R
R
H
D
P
L
K
I
W
K
L
S
P
M
D
I
A
A
L
S
K
W
D
D
Y
T
G
K
R
D
R
M
L
K
E
T
H
T
E
H
G
P
W
A
V
I
R
G
N
D
K
R
R
S
R
I
N
V
I
R
H
M
L
T
K
L
D
Y
-
33
HHSearch
51.11
33%
35
- C5 -
-
3CZQ
1
?
A:
[54-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
K
L
D
R
E
E
Y
E
E
T
L
T
K
L
Q
I
E
L
V
K
V
Q
F
W
M
---
Q
---
A
-
T
----
G
K
R
V
M
A
V
F
E
G
R
D
A
A
G
K
G
G
A
I
H
A
T
T
A
N
M
N
P
R
S
A
R
V
V
A
L
T
K
P
T
E
T
E
R
G
Q
W
Y
F
Q
R
Y
V
A
T
F
P
T
A
G
E
F
V
L
F
D
R
S
W
Y
N
R
A
G
V
E
P
V
M
G
F
C
T
P
D
Q
Y
E
Q
F
L
K
E
A
P
R
F
E
E
M
I
A
N
E
G
I
H
L
F
K
F
W
I
N
I
G
R
E
M
Q
L
K
R
F
H
D
R
R
H
D
P
L
K
I
W
K
L
S
P
M
D
I
A
A
L
S
K
W
D
D
Y
T
G
K
R
D
R
M
L
K
E
T
H
T
E
H
G
P
W
A
V
I
R
G
N
D
K
R
R
S
R
I
N
V
I
R
H
M
L
T
K
L
D
Y
-
4
PsiBlast_PDB
50.51
32%
39
- C5 -
-
3CZQ
1
?
A:
[52-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
-------
K
K
K
L
D
R
E
E
Y
E
E
T
L
T
K
L
Q
I
E
L
V
K
V
---
Q
F
W
M
Q
---
A
-
T
----
G
K
R
V
M
A
V
F
E
G
R
D
A
A
G
K
G
G
A
I
H
A
T
T
A
N
M
N
P
R
S
A
R
V
V
A
L
T
K
P
T
E
T
E
R
G
Q
W
Y
F
Q
R
Y
V
A
T
F
P
T
A
G
E
F
V
L
F
D
R
S
W
Y
N
R
A
G
V
E
P
V
M
G
F
C
T
P
D
Q
Y
E
Q
F
L
K
E
A
P
R
F
E
E
M
I
A
N
E
G
I
H
L
F
K
F
W
I
N
I
G
R
E
M
Q
L
K
R
F
H
D
R
R
H
D
P
L
K
I
W
K
L
S
P
M
D
I
A
A
L
S
K
W
D
D
Y
T
G
K
R
D
R
M
L
K
E
T
H
T
E
H
G
P
W
A
V
I
R
G
N
D
K
R
R
S
R
I
N
V
I
R
H
M
L
T
K
L
D
Y
D