@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLX4: (2017-11-05 )
MIHAGNAITVQMLADGIAEFRFDLQGESVNKFNRATIEDFKAAIAAVKANNDIKGLVVTSGKSTFIVGADITEFGQNFAQGEKAIVDWLMPVHEIFNSFEDLDLPKVAAINGIALGGGFEMCLVCDYRVMSEAAQVGLPEIKLGIYPGFGGSVRLSRLIGIDNAVEWMAMATPKKPAAALKDGAVDAVVAADKLLDAATDLVKQAISGRLNWKAKRQEKLEAVKLNPLEQMMAFNTAKGAVLAKANPAQYPAPKLLLDSLQAGASLARDEALKAEAEGFAKAAVTPQAEALIGLFINDQVVKKASKQHEKGAHPVNQAAVLGAGIMGGGIAYQAASKGTPIIMKDIGNPQLALGMKEANNLLTKQVERKKMKPAQMGETLARIRPTLSYEEFKEVDIVIEAVTENPKVKEIVLAETEKNVRENTIIASNTSTISITRLAKALQRPENFVGMHFFNPVHMMPLVEVIRGEKTSEEAIATTVVLAQKMGKTPIVVNDCPGFLVNRVLFPYFGAFDLLVKDGADFQQIDNVMSKFGWPMGPAYLIDVVGIDTGVHGAEVMAEGFPDRMKPDYKGAIEAMYEAKRLGQKNDVGFYKYELDKKGKKAKTVDPTAYEVIAPFVTGEKREFDNQEIIDRMMLALCNETARCLEDNIVATASEADMAMIMGIGFPPFRGGPCRYIDQTGVAEYVALCDKYAHLGKAYEAPQMLRDMAANNKKFYG
Atome Classification :
(22 SA)
.........10........20........30........40........-50.-.......60..-......70........80-.-.......90.-.......100.......110.......120.......130--.......140.......150.......160..-.-....170.......180.......190....-..---..200....------.------..210..-.....220.--...-...230.......240...-....250--........260.......270.......280.......290......-.300...-----....310........320.......330.......340.......350.......360.......370......-----.380--..-.....390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......-510.......-520.......530..--......540.......550-------.......560--.--.---.....--.-570.........580.......590.......600.......610.......---620.......630.......640.......650.......660.......670.....------..------680.......690-..-.....700.......710.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MIHAG
N
A
I
T
V
Q
M
L
A
D
G
I
A
E
F
R
FDLQGESVNKF
N
R
A
T
I
E
D
F
K
A
A
I
A
A
V
KA-NND-I
K
G
L
V
VTSGK
S
-
T
F
I
V
GA
D
I
T
E
F
G
Q
N
F
AQ
G
-
E
-
K
A
I
V
D
W
L
M
P
V
-
H
E
I
F
N
S
F
E
DLDLP
K
V
A
A
I
N
G
I
A
LGGG
F
E
M
C
L
V
CD
Y
R
V
M
S
E
--
A
A
QVGL
P
E
I
K
L
G
I
YPGFGGS
V
R
L
S
R
L
IGID
N
A
-
V
-
E
W
M
AMATPKK
P
A
A
A
LKDGA
V
D
A
V
V
A
A
-
D
K
L
L
-
D
A
---
A
T
D
L
V
K
Q
A
I------S------GRLNW
K
A
-
K
R
Q
EK
L
E
AV--KL
N
-
P
L
E
Q
M
M
A
FNTAK
G
A
V
L
AKA-NPAQYP---
A
P
K
L
L
L
D
S
L
Q
A
G
A
S
LA
R
D
E
A
L
K
A
E
A
EGFAKAAVTP
Q
A
E
A
L
I
G
L
FIN
D
-
Q
V
V
K
K
A
S
-----
K
Q
HEK-GAHP
V
N
Q
A
A
V
LGAGIMGGGI
A
Y
QAASKGT
P
I
I
M
KDIGNPQ
L
A
L
G
M
K
E
A
N
N
L
L
T
K
Q
V
E
R
KKM
K
P
A
Q
M
G
E
-----
T
L
A
R
--IR-PTL
S
Y
E
E
F
K
E
V
D
I
V
I
E
AVTENPK
V
K
E
I
V
L
AETEKNVRE
N
T
I
I
ASNT
S
T
I
S
I
T
R
L
A
K
A
L
QR
P
E
N
F
V
G
M
HFFN
P
V
H
M
M
P
L
V
E
V
IRGEKT
S
E
E
A
I
A
T
T
V
V
L
A
Q
KMGKT
P
I
V
VNDC
P
G
F
L
V
N
R
V
L
F
P
Y
F
-
G
A
F
D
L
L
VKDG-A
D
F
Q
Q
I
D
N
V
M
S
-
K
FG--WPMG
P
A
Y
L
I
D
V
V
GIDTGV
H
-------
G
A
E
V
M
A
EGF---P--D---RMKPD--
Y
-
K
--
G
A
I
E
A
M
Y
E
A
K
RLGQKNDV
G
F
Y
K
Y
ELDKKGKKAKTVDP
T
A
Y
E
V
I
A
PFVTG---EKREFD
N
Q
E
I
I
D
R
M
M
L
A
L
C
N
E
T
A
R
C
L
E
DNIVATASEA
D
M
A
M
I
M
GIGFPPFRGGP
C
R
Y
I------
D
Q
------
T
G
V
A
E
Y
V
A
L
C
D
K
Y
-
A
H
-LG
K
A
Y
E
A
P
Q
M
L
R
D
M
AANNKKFYG
24
PsiBlast_CBE
97.04
63%
-107
- C2 -
-
1WDK
3
FADB_PSEFR
B:
[1-715]
M
I
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
-
D
-
A
E
L
I
A
G
N
L
E
A
-
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
-
D
K
L
G
-
A
A
---
A
L
D
L
I
K
R
A
I
------
S
------
G
E
L
D
Y
K
A
-
K
R
Q
P
K
L
E
K
L
--
K
L
N
-
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
-
G
P
-
N
Y
P
---
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
K
K
A
-----
K
V
Y
D
K
-
I
A
K
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
-----
V
L
N
G
--
I
R
-
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
-
G
G
F
A
K
L
V
S
A
G
-
V
D
F
V
R
I
D
K
V
M
E
-
K
F
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
-------
G
R
D
V
M
A
E
G
F
---
P
--
D
---
R
M
K
D
D
--
R
-
R
--
S
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
A
D
----
Q
K
K
L
V
D
S
S
V
L
E
V
L
K
P
I
V
Y
----
E
Q
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
------
I
G
V
A
E
F
V
A
L
A
D
Q
Y
-
A
E
-
L
G
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
23
PsiBlast_CBE
95.83
63%
-104
* C1 *
-
1WDL
2
FADB_PSEFR
B:
[1-715]
M
I
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
-
D
-
A
E
L
I
A
G
N
L
E
A
-
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
-
D
K
L
G
-
A
A
---
A
L
D
L
I
K
R
A
I
------
S
------
G
E
L
D
Y
K
A
-
K
R
Q
P
K
L
E
K
L
--
K
L
N
-
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
-
G
P
-
N
Y
P
---
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
K
K
A
-----
K
V
Y
D
K
-
I
A
K
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
-----
V
L
N
G
--
I
R
-
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
-
G
G
F
A
K
L
V
S
A
G
-
V
D
F
V
R
I
D
K
V
M
E
-
K
F
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
-------
G
R
D
V
M
A
E
G
F
---
P
--
D
---
R
M
K
D
D
--
R
-
R
--
S
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
---------
K
L
V
D
S
S
V
L
E
V
L
K
P
I
V
Y
----
E
Q
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
------
I
G
V
A
E
F
V
A
L
A
D
Q
Y
-
A
E
-
L
G
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
22
PsiBlast_CBE
95.63
63%
-107
- C2 -
-
1WDM
1
FADB_PSEFR
B:
[1-715]
M
I
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
-
D
-
A
E
L
I
A
G
N
L
E
A
-
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
-
D
K
L
G
-
A
A
---
A
L
D
L
I
K
R
A
I
------
S
------
G
E
L
D
Y
K
A
-
K
R
Q
P
K
L
E
K
L
--
K
L
N
-
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
-
G
P
-
N
Y
P
---
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
K
K
A
-----
K
V
Y
D
K
-
I
A
K
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
-----
V
L
N
G
--
I
R
-
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
-
G
G
F
A
K
L
V
S
A
G
-
V
D
F
V
R
I
D
K
V
M
E
-
K
F
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
-------
G
R
D
V
M
A
E
G
F
---
P
--
D
---
R
M
K
D
D
--
R
-
R
--
S
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
-----
K
Q
K
K
L
V
D
S
S
V
L
E
V
L
K
P
I
V
Y
----
E
Q
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
------
I
G
V
A
E
F
V
A
L
A
D
Q
Y
-
A
E
-
L
G
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
2
PsiBlast_PDB
95.58
63%
-107
- C2 -
-
1WDM
2
FADB_PSEFR
A:
[1-715]
M
I
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
-
D
-
A
E
L
I
A
G
N
L
E
A
-
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
-
D
K
L
G
-
A
A
---
A
L
D
L
I
K
R
A
I
------
S
------
G
E
L
D
Y
K
A
-
K
R
Q
P
K
L
E
K
L
--
K
L
N
-
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
-
G
P
-
N
Y
P
---
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
K
K
A
-----
K
V
Y
D
K
-
I
A
K
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
-----
V
L
N
G
--
I
R
-
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
-
G
G
F
A
K
L
V
S
A
G
-
V
D
F
V
R
I
D
K
V
M
E
-
K
F
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
-------
G
R
D
V
M
A
E
G
F
---
P
--
D
---
R
M
K
D
D
--
R
-
R
--
S
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
--------
K
K
L
V
D
S
S
V
L
E
V
L
K
P
I
V
Y
----
E
Q
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
------
I
G
V
A
E
F
V
A
L
A
D
Q
Y
-
A
E
-
L
G
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
112
Fugue
95.20
62%
-107
- C2 -
-
1WDK
3
FADB_PSEFR
A:
[1-715]
M
I
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
-
D
-
A
E
L
I
A
G
N
L
E
A
-
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
-
D
K
L
G
-
A
A
---
A
L
D
L
I
K
R
A
I
------
S
------
G
E
L
D
Y
K
A
-
K
R
Q
P
K
L
E
K
L
--
K
L
N
-
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
-
G
P
-
N
Y
P
---
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
K
K
A
-----
K
V
Y
D
K
-
I
A
K
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
-----
V
L
N
G
--
I
R
-
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
-
G
G
F
A
K
L
V
S
A
G
-
V
D
F
V
R
I
D
K
V
M
E
-
K
F
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
-------
G
R
D
V
M
A
E
G
F
---
P
--
D
---
R
M
K
D
D
--
R
-
R
--
S
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
--------
K
K
L
V
D
S
S
V
L
E
V
L
K
P
I
V
Y
---
E
Q
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
------
I
G
V
A
E
F
V
A
L
A
D
Q
Y
-
A
E
-
L
G
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
21
PsiBlast_CBE
95.15
63%
-105
- C2 -
-
2D3T
1
FADB_PSEFR
B:
[1-715]
M
I
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
-
D
-
A
E
L
I
A
G
N
L
E
A
-
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
-
D
K
L
G
-
A
A
---
A
L
D
L
I
K
R
A
I
------
S
------
G
E
L
D
Y
K
A
-
K
R
Q
P
K
L
E
K
L
--
K
L
N
-
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
-
G
P
-
N
Y
P
---
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
K
K
A
-----
K
V
Y
D
K
-
I
A
K
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
-----
V
L
N
G
--
I
R
-
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
-
G
G
F
A
K
L
V
S
A
G
-
V
D
F
V
R
I
D
K
V
M
E
-
K
F
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
-------
G
R
D
V
M
A
E
G
F
---
P
--
D
---
R
M
K
D
D
--
R
-
R
--
S
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
A
D
----
Q
K
K
L
V
D
S
S
V
L
E
V
L
K
P
I
V
Y
----
E
Q
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
------
I
G
V
A
E
F
V
A
L
A
D
Q
Y
-
A
E
-
L
G
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
1
PsiBlast_PDB
94.24
63%
-98
- C2 -
-
1WDL
4
FADB_PSEFR
A:
[1-715]
M
I
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
K
D
-
V
F
I
V
G
A
D
I
T
E
F
V
E
N
F
K
L
P
-
D
-
A
E
L
I
A
G
N
L
E
A
-
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
-
D
K
L
G
-
A
A
---
A
L
D
L
I
K
R
A
I
------
S
------
G
E
L
D
Y
K
A
-
K
R
Q
P
K
L
E
K
L
--
K
L
N
-
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
-
G
P
-
N
Y
P
---
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
-
Q
E
L
K
K
K
A
-----
K
V
Y
D
K
-
I
A
K
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
-----
V
L
N
G
--
I
R
-
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
-
G
G
F
A
K
L
V
S
A
G
-
V
D
F
V
R
I
D
K
V
M
E
-
K
F
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
-------
G
R
D
V
M
A
E
G
F
---
P
--
D
---
R
M
K
D
D
--
R
-
R
--
S
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
A
D
K
K
G
K
Q
K
K
L
V
D
S
S
V
L
E
V
L
K
P
I
V
Y
----
E
Q
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
------
I
G
V
A
E
F
V
A
L
A
D
Q
Y
-
A
E
-
L
G
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
121
HHSearch
80.00
61%
-11
- C2 -
-
1WDL
4
FADB_PSEFR
A:
[1-715]
M
I
Y
E
G
K
A
I
T
V
T
A
L
E
S
G
I
V
E
L
K
F
D
L
K
G
E
S
V
N
K
F
N
R
L
T
L
N
E
L
R
Q
A
V
D
A
I
K
A
-
D
A
S
-
V
K
G
V
I
V
S
S
G
-
K
D
V
F
I
V
G
A
D
I
T
E
F
V
-
E
N
F
K
L
P
D
-
A
E
L
I
A
G
-
N
L
E
A
N
K
I
F
S
D
F
E
D
L
N
V
P
T
V
A
A
I
N
G
I
A
L
G
G
G
L
E
M
C
L
A
A
D
F
R
V
M
A
D
--
S
A
K
I
G
L
P
E
V
K
L
G
I
Y
P
G
F
G
G
T
V
R
L
P
R
L
I
G
V
D
N
A
-
V
-
E
W
I
A
S
G
K
E
N
R
A
E
D
A
L
K
V
S
A
V
D
A
V
V
T
A
-
D
-
K
L
G
A
A
---
A
L
D
L
I
K
R
A
I
--------------
S
-
G
E
L
D
Y
K
A
K
R
Q
P
K
L
E
KL
K
L
N
-
A
I
E
Q
M
M
A
F
E
T
A
K
G
F
V
A
G
Q
A
-
G
P
-
N
Y
P
---
A
P
V
E
A
I
K
T
I
Q
K
A
A
N
F
G
R
D
K
A
L
E
V
E
A
A
G
F
A
K
L
A
K
T
S
A
S
N
C
L
I
G
L
F
L
N
D
Q
E
L
K
K
K
A
K
-----
V
-
Y
D
K
-
I
A
K
D
V
K
Q
A
A
V
L
G
A
G
I
M
G
G
G
I
A
Y
Q
S
A
S
K
G
T
P
I
L
M
K
D
I
N
E
H
G
I
E
Q
G
L
A
E
A
A
K
L
L
V
G
R
V
D
K
G
R
M
T
P
A
K
M
A
E
-----
V
L
N
G
--
I
R
-
P
T
L
S
Y
G
D
F
G
N
V
D
L
V
V
E
A
V
V
E
N
P
K
V
K
Q
A
V
L
A
E
V
E
N
H
V
R
E
D
A
I
L
A
S
N
T
S
T
I
S
I
S
L
L
A
K
A
L
K
R
P
E
N
F
V
G
M
H
F
F
N
P
V
H
M
M
P
L
V
E
V
I
R
G
E
K
S
S
D
L
A
V
A
T
T
V
A
Y
A
K
K
M
G
K
N
P
I
V
V
N
D
C
P
G
F
L
V
N
R
V
L
F
P
Y
F
-
G
G
F
A
K
L
V
S
A
G
-
V
D
F
V
R
I
D
K
V
M
E
-
K
F
G
--
W
P
M
G
P
A
Y
L
M
D
V
V
G
I
D
T
G
H
H
-------
G
R
D
V
M
A
E
G
F
---
P
--
D
R--
M
K
D
D
R
----
R
--
S
A
I
D
A
L
Y
E
A
K
R
L
G
Q
K
N
G
K
G
F
Y
A
Y
E
A
D
K
K
G
K
Q
K
K
L
V
D
S
S
V
L
E
V
L
K
P
I
-
V
Y
---
E
Q
R
D
V
T
D
E
D
I
I
N
W
M
M
I
P
L
C
L
E
T
V
R
C
L
E
D
G
I
V
E
T
A
A
E
A
D
M
G
L
V
Y
G
I
G
F
P
L
F
R
G
G
A
L
R
Y
I
------
D
S
------
I
G
V
A
E
F
V
A
L
A
D
Q
Y
-
A
E
-
L
G
A
L
Y
H
P
T
A
K
L
R
E
M
A
K
N
G
Q
S
F
F
G
27
PsiBlast_CBE
64.10
34%
5
- C2 -
-
4B3H
2
?
B:
[20-734]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
-
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
-
A
-
G
D
V
F
N
T
V
E
T
I
-
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
VK
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
-
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
E
E
L
V
-
P
A
---
A
K
A
W
I
K
E
E
L
K
ANPDG
A
------
G
V
Q
P
W
D
K
-
K
G
Y
K
M
P
G
G
T
--
P
S
S
-
P
--
G
L
A
A
I
L
P
S
F
P
S
N
L
R
K
Q
L
K
G
A
P
M
P
---
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
A
G
G
-----
S
R
P
E
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
E
R
S
D
A
-----
L
L
A
R
--
I
T
-
P
T
A
D
A
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
-
N
E
A
L
A
M
L
G
E
G
-
V
E
P
A
S
I
E
Q
A
G
S
-
Q
A
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
-------
I
A
V
A
T
R
K
G
V
---
E
--
D
A
GG
T
Y
Q
P
H
P-
A
-
E
--
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
---
A
D
G
K
R
S
G
-
L
W
P
G
L
R
E
T
---
F
K
S
G
---
S
S
Q
P
-
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
YSGP
A
G
------
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
-
Y
G
D
R
F
L
P
P
E
S
L
------------
5
PsiBlast_PDB
63.70
34%
5
- C2 -
-
4B3I
4
?
A:
[20-734]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
-
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
-
A
-
G
D
V
F
N
T
V
E
T
I
-
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
VK
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
-
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
E
E
L
V
-
P
A
---
A
K
A
W
I
K
E
E
L
K
A
NPDG
A
------
G
V
Q
P
W
D
K
-
K
G
Y
K
M
P
G
G
T
--
P
S
S
-
P
--
G
L
A
A
I
L
P
S
F
P
S
N
L
R
K
Q
L
K
G
A
P
M
P
---
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
A
G
G
-----
S
R
P
E
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
E
R
S
D
A
-----
L
L
A
R
--
I
T
-
P
T
A
D
A
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
-
N
E
A
L
A
M
L
G
E
G
-
V
E
P
A
S
I
E
Q
A
G
S
-
Q
A
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
-------
I
A
V
A
T
R
K
G
V
---
E
--
D
A
G
G
T
Y
Q
P
H
P
-
A
-
E
--
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
---
A
D
G
K
R
S
G
-
L
W
P
G
L
R
E
T
---
F
K
S
G
---
S
S
Q
P
-
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
YSGP
A
G
------
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
-
Y
G
D
R
F
L
P
P
E
S
L
------------
4
PsiBlast_PDB
63.36
34%
6
- C2 -
-
4B3H
4
?
A:
[20-734]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
-
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
-
A
-
G
D
V
F
N
T
V
E
T
I
-
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
VK
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
-
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
E
E
L
V
-
P
A
---
A
K
A
W
I
K
E
E
L
K
A
NPDG
A
------
G
V
Q
P
W
D
K
-
K
G
Y
K
M
P
G
G
T
--
P
S
S
-
P
--
G
L
A
A
I
L
P
S
F
P
S
N
L
R
K
Q
L
K
G
A
P
M
P
---
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
A
G
G
-----
S
R
P
E
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
E
R
S
D
A
-----
L
L
A
R
--
I
T
-
P
T
A
D
A
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
-
N
E
A
L
A
M
L
G
E
G
-
V
E
P
A
S
I
E
Q
A
G
S
-
Q
A
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
-------
I
A
V
A
T
R
K
G
V
---
E
--
D
A
G
G
T
Y
Q
P
H
P
-
A
-
E
--
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
---
A
D
G
K
R
S
G
-
L
W
P
G
L
R
E
T
---
F
K
S
G
---
S
S
Q
P
-
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
YSGP
A
G
------
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
-
Y
G
D
R
F
L
P
P
E
S
L
------------
6
PsiBlast_PDB
63.35
34%
4
- C2 -
-
4B3J
5
?
A:
[20-734]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
-
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
-
A
-
G
D
V
F
N
T
V
E
T
I
-
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
VK
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
-
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
E
E
L
V
-
P
A
---
A
K
A
W
I
K
E
E
L
K
A
NPDG
A
------
G
V
Q
P
W
D
K
-
K
G
Y
K
M
P
G
G
T
--
P
S
S
-
P
--
G
L
A
A
I
L
P
S
F
P
S
N
L
R
K
Q
L
K
G
A
P
M
P
---
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
A
G
G
-----
S
R
P
E
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
E
R
S
D
A
-----
L
L
A
R
--
I
T
-
P
T
A
D
A
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
-
N
E
A
L
A
M
L
G
E
G
-
V
E
P
A
S
I
E
Q
A
G
S
-
Q
A
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
-------
I
A
V
A
T
R
K
G
V
---
E
--
D
A
G
G
T
Y
Q
P
H
P
-
A
-
E
--
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
---
A
D
G
K
R
S
G
-
L
W
P
G
L
R
E
T
---
F
K
S
G
---
S
S
Q
P
-
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
YSGP
A
G
------
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
-
Y
G
D
R
F
L
P
P
E
S
L
------------
26
PsiBlast_CBE
63.25
34%
8
- C2 -
-
4B3I
2
?
B:
[20-734]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
-
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
-
A
-
G
D
V
F
N
T
V
E
T
I
-
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
VK
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
-
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
E
E
L
V
-
P
A
---
A
K
A
W
I
K
E
E
L
K
A
N
PDG
A
------
G
V
Q
P
W
D
K
-
K
G
Y
K
M
P
G
G
T
--
P
S
S
-
P
--
G
L
A
A
I
L
P
S
F
P
S
N
L
R
K
Q
L
K
G
A
P
M
P
---
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
A
G
G
-----
S
R
P
E
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
E
R
S
D
A
-----
L
L
A
R
--
I
T
-
P
T
A
D
A
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
-
N
E
A
L
A
M
L
G
E
G
-
V
E
P
A
S
I
E
Q
A
G
S
-
Q
A
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
-------
I
A
V
A
T
R
K
G
V
---
E
--
D
A
G
G
T
Y
Q
P
H
P-
A
-
E
--
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
---
A
D
G
K
R
S
G
-
L
W
P
G
L
R
E
T
---
F
K
S
G
---
S
S
Q
P
-
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
YSGP
A
G
------
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
-
Y
G
D
R
F
L
P
P
E
S
L
------------
25
PsiBlast_CBE
63.25
34%
8
- C2 -
-
4B3J
2
?
B:
[20-734]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
-
E
K
D
S
I
T
G
V
V
V
A
S
A
K
K
-
T
F
F
A
G
G
D
V
K
T
M
I
Q
A
R
P
E
D
-
A
-
G
D
V
F
N
T
V
E
T
I
-
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
VK
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
F
V
-
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
V
E
E
L
V
-
P
A
---
A
K
A
W
I
K
E
E
L
K
A
NPDG
A
------
G
V
Q
P
W
D
K
-
K
G
Y
K
M
P
G
G
T
--
P
S
S
-
P
--
G
L
A
A
I
L
P
S
F
P
S
N
L
R
K
Q
L
K
G
A
P
M
P
---
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
A
G
G
-----
S
R
P
E
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
E
R
S
D
A
-----
L
L
A
R
--
I
T
-
P
T
A
D
A
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
-
N
E
A
L
A
M
L
G
E
G
-
V
E
P
A
S
I
E
Q
A
G
S
-
Q
A
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
-------
I
A
V
A
T
R
K
G
V
---
E
--
D
A
GG
T
Y
Q
P
H
P-
A
-
E
--
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
---
A
D
G
K
R
S
G
-
L
W
P
G
L
R
E
T
---
F
K
S
G
---
S
S
Q
P
-
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
V
G
YSGP
A
G
------
T
G
K
A
A
F
V
A
R
A
R
E
L
A
A
A
-
Y
G
D
R
F
L
P
P
E
S
L
------------
124
HHSearch
61.20
35%
22
- C2 -
-
4B3I
4
?
A:
[20-733]
-----
N
T
I
Q
W
D
K
D
A
D
G
I
V
T
L
T
M
D
D
P
S
G
S
T
N
V
M
N
E
A
Y
I
E
S
M
G
K
A
V
D
R
L
V
A
E
K
D
S
-
I
T
G
V
V
V
A
S
A
-
K
K
T
F
F
A
G
G
D
V
K
T
M
I
-
Q
A
R
P
E
-
D
A
G
D
V
F
N
T
-
V
E
T
I
K
R
Q
L
R
T
L
E
T
L
G
K
P
V
V
A
A
I
N
G
A
A
L
G
G
G
L
E
I
A
L
A
C
H
H
R
I
A
A
D
VK
G
S
Q
L
G
L
P
E
V
T
L
G
L
L
P
G
G
G
G
V
T
R
T
V
R
M
F
G
I
Q
N
A
-
F
V
S
V
L
A
Q
G
T
R
F
K
P
A
K
A
K
E
I
G
L
V
D
E
L
V
A
T
-
V
E
E
L
V
P
A
---
A
K
A
W
I
K
E
E
L
------
K
A
NPDGA
G
V
Q
P
W
D
K
-
K
G
Y
K
M
P
G
G
T
--
P
S
S
P
G
L
A
--
A
I
L
P
S
F
P
S
N
L
R
K
Q
L
-
K
G
A
P
M
P
---
A
P
R
A
I
L
A
A
A
V
E
G
A
Q
V
D
F
D
T
A
S
R
I
E
S
R
Y
F
A
S
L
V
T
G
Q
V
A
K
N
M
M
Q
A
F
F
F
D
L
Q
A
I
N
A
G
G
-----
S
R
P
E
G
I
G
K
T
P
I
K
R
I
G
V
L
G
A
G
M
M
G
A
G
I
A
Y
V
S
A
K
A
G
Y
E
V
V
L
K
D
V
S
L
E
A
A
A
K
G
K
G
Y
S
E
K
L
E
A
K
A
L
E
R
G
R
T
T
Q
E
R
S
D
A
-----
L
L
A
R
--
I
T
-
P
T
A
D
A
A
D
F
K
G
V
D
F
V
I
E
A
V
F
E
N
Q
E
L
K
H
K
V
F
G
E
I
E
D
I
V
E
P
N
A
I
L
G
S
N
T
S
T
L
P
I
T
G
L
A
T
G
V
K
R
Q
E
D
F
I
G
I
H
F
F
S
P
V
D
K
M
P
L
V
E
I
I
K
G
E
K
T
S
D
E
A
L
A
R
V
F
D
Y
T
L
A
I
G
K
T
P
I
V
V
N
D
S
R
G
F
F
T
S
R
V
I
G
T
F
V
-
N
E
A
L
A
M
L
G
E
G
-
V
E
P
A
S
I
E
Q
A
G
S
-
Q
A
G
--
Y
P
A
P
P
L
Q
L
S
D
E
L
N
L
E
L
M
H
K
-------
I
A
V
A
T
R
K
G
V
E
D
A
G
--
G
---
T
Y
Q
P
H
--
P
A
E
--
A
V
V
E
K
M
I
E
L
G
R
S
G
R
L
K
G
A
G
F
Y
E
Y
A
D
G
K
R
-
S
---
G
L
W
P
G
L
R
E
T
F
K
----
S
---
G
S
S
Q
P
P
L
Q
D
M
I
D
R
M
L
F
A
E
A
L
E
T
Q
K
C
L
D
E
G
V
L
T
S
T
A
D
A
N
I
G
S
I
M
G
I
G
F
P
P
W
T
G
G
S
A
Q
F
I
------
V
G
YSGPAG
T
G
K
A
A
F
V
A
R
A
R
E
L
-
A
A
A
Y
G
D
R
F
L
P
P
E
S
-------------
13
PsiBlast_PDB
60.65
29%
-27
- C2 -
-
5MGB
5
ECHP_RAT
A:
[41-701]
----------------------------
V
N
A
V
S
P
T
V
I
R
E
V
R
N
G
L
Q
K
A
G
S
-
D
H
T
-
V
K
A
I
V
I
C
G
A
N
G
-
N
F
C
A
G
A
D
I
H
G
F
-
S
A
F
T
P
G
----------
L
A
L
-
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
A
--
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
-
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
A
V
V
K
S
-
D
P
V
E
-
E
A
I
K
F
A
Q
K
I
I
D
K
P
I
------
E
------
P
R
R
I
F
N
---------------
K
-
P
V
P
S
L
P
N
M
D
S
V
F
A
E
A
I
A
K
V
-
R
-
K
Q
Y
P
GV
L
A
P
E
T
C
V
R
S
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
-
K
S
A
N
K
W
S
TPSGA
S
W
K
T
A
-
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
----
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
A
H
Q
N
G
Q
-----
A
S
A
K
PK
L
R
-
F
S
S
S
T
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
-
N
Q
G
F
F
L
L
E
E
G
-
S
K
P
E
D
V
D
G
V
L
E
-
E
F
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
GL
T
G
P
S
L
P
P
G
T
---
P
--
V
---
R
K
R
G
N
S
R
Y
-
S
--
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
--
D
K
P
L
G
R
I
H
K
P
D
P
W
L
S
T
F
L
S
Q
Y
R
E
V
H
HI
E
Q
R
T
I
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
------
A
S
------
V
G
L
P
T
V
L
E
K
L
Q
K
Y
---------------------------
14
PsiBlast_PDB
60.61
29%
-27
- C2 -
-
3ZWB
3
ECHP_RAT
A:
[41-701]
----------------------------
V
N
A
V
S
P
T
V
I
R
E
V
R
N
G
L
Q
K
A
G
S
-
D
H
T
-
V
K
A
I
V
I
C
G
A
N
G
-
N
F
C
A
G
A
D
I
H
G
F
-
S
A
F
T
P
G
----------
L
A
L
-
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
A
--
K
A
R
V
G
L
P
A
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
-
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
A
V
V
K
S
-
D
P
V
E
-
E
A
I
K
F
A
Q
K
I
I
D
K
P
I
------
E
------
P
R
R
I
F
N
---------------
K
-
P
V
P
S
L
P
N
M
D
S
V
F
A
E
A
I
A
K
V
-
R
-
K
Q
Y
P
GV
L
A
P
E
T
C
V
R
S
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
-
K
S
A
N
K
W
S
TPSGA
S
W
K
T
A
-
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
----
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
A
H
Q
N
G
Q
-----
A
S
A
K
PK
L
R
-
F
S
S
S
T
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
-
N
Q
G
F
F
L
L
E
E
G
-
S
K
P
E
D
V
D
G
V
L
E
-
E
F
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
GL
T
G
P
S
L
P
P
G
T
---
P
--
V
---
R
K
R
G
N
S
R
Y
-
S
--
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
--
D
K
P
L
G
R
I
H
K
P
D
P
W
L
S
T
F
L
S
Q
Y
R
E
V
H
HI
E
Q
R
T
I
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
------
A
S
------
V
G
L
P
T
V
L
E
K
L
Q
K
Y
---------------------------
11
PsiBlast_PDB
60.51
29%
-25
- C2 -
-
3ZWC
3
ECHP_RAT
A:
[41-701]
----------------------------
V
N
A
V
S
P
T
V
I
R
E
V
R
N
G
L
Q
K
A
G
S
-
D
H
T
-
V
K
A
I
V
I
C
G
A
N
G
-
N
F
C
A
G
A
D
I
H
G
F
-
S
A
F
T
P
G
----------
L
A
L
-
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
A
--
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
-
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
A
V
V
K
S
-
D
P
V
E
-
E
A
I
K
F
A
Q
K
I
I
D
K
P
I
------
E
------
P
R
R
I
F
N
---------------
K
-
P
V
P
S
L
P
N
M
D
S
V
F
A
E
A
I
A
K
V
-
R
-
K
Q
Y
P
GV
L
A
P
E
T
C
V
R
S
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
-
K
S
A
N
K
W
S
TPSGA
S
W
K
T
A
-
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
----
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
A
H
Q
N
G
Q
-----
A
S
A
K
PK
L
R
-
F
S
S
S
T
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
-
N
Q
G
F
F
L
L
E
E
G
-
S
K
P
E
D
V
D
G
V
L
E
-
E
F
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
GL
T
G
P
S
L
P
P
G
T
---
P
--
V
---
R
K
R
G
N
S
R
Y
-
S
--
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
--
D
K
P
L
G
R
I
H
K
P
D
P
W
L
S
T
F
L
S
Q
Y
R
E
V
H
HI
E
Q
R
T
I
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
------
A
S
------
V
G
L
P
T
V
L
E
K
L
Q
K
Y
---------------------------
8
PsiBlast_PDB
60.43
29%
-23
- C2 -
-
3ZW8
1
ECHP_RAT
A:
[41-701]
----------------------------
V
N
A
V
S
P
T
V
I
R
E
V
R
N
G
L
Q
K
A
G
S
-
D
H
T
-
V
K
A
I
V
I
C
G
A
N
G
-
N
F
C
A
G
A
D
I
H
G
F
-
S
A
F
T
P
G
----------
L
A
L
-
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
A
--
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
-
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
A
V
V
K
S
-
D
P
V
E
-
E
A
I
K
F
A
Q
K
I
I
D
K
P
I
------
E
------
P
R
R
I
F
N
---------------
K
-
P
V
P
S
L
P
N
M
D
S
V
F
A
E
A
I
A
K
V
-
R
-
K
Q
Y
P
GV
L
A
P
E
T
C
V
R
S
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
-
K
S
A
N
K
W
S
TPSGA
S
W
K
T
A
-
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
----
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
A
H
Q
N
G
Q
-----
A
S
A
K
PK
L
R
-
F
S
S
S
T
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
-
N
Q
G
F
F
L
L
E
E
G
-
S
K
P
E
D
V
D
G
V
L
E
-
E
F
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
GL
T
G
P
S
L
P
P
G
T
---
P
--
V
---
R
K
R
G
N
S
R
Y
-
S
--
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
--
D
K
P
L
G
R
I
H
K
P
D
P
W
L
S
T
F
L
S
Q
Y
R
E
V
H
HI
E
Q
R
T
I
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
------
A
S
------
V
G
L
P
T
V
L
E
K
L
Q
K
Y
---------------------------
7
PsiBlast_PDB
60.27
29%
-26
- C2 -
-
2X58
3
ECHP_RAT
A:
[26-686]
----------------------------
V
N
A
V
S
P
T
V
I
R
E
V
R
N
G
L
Q
K
A
G
S
-
D
H
T
-
V
K
A
I
V
I
C
G
A
N
G
-
N
F
C
A
G
A
D
I
H
G
F
S
A
-
F
T
P
G
----------
L
A
L
-
G
S
L
V
D
E
I
Q
R
Y
Q
K
P
V
L
A
A
I
Q
G
V
A
L
G
G
G
L
E
L
A
L
G
C
H
Y
R
I
A
N
A
--
K
A
R
V
G
L
P
E
V
T
L
G
I
L
P
G
A
R
G
T
Q
L
L
P
R
V
V
G
V
P
V
A
-
L
-
D
L
I
T
S
G
K
Y
L
S
A
D
E
A
L
R
L
G
I
L
D
A
V
V
K
S
-
D
P
V
E
-
E
A
I
K
F
A
Q
K
I
I
D
K
P
I
------
E
------
P
R
R
I
F
N
---------------
K
-
P
V
P
S
L
P
N
M
D
S
V
F
A
E
A
I
A
K
V
-
R
-
K
Q
Y
P
GVL
A
P
E
T
C
V
R
S
I
Q
A
S
V
K
H
P
Y
E
V
G
I
K
E
E
E
K
L
F
M
Y
L
R
A
S
G
Q
A
K
A
L
Q
Y
A
F
F
A
E
-
K
S
A
N
K
W
S
TPSGA
S
W
K
T
A
-
S
A
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
----
D
A
A
K
K
I
I
T
F
T
L
E
K
E
A
S
R
A
H
Q
N
G
Q
-----
A
S
A
K
PK
L
R
-
F
S
S
S
T
K
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
-
N
Q
G
F
F
L
L
E
E
G
-
S
K
P
E
D
V
D
G
V
L
E
-
E
F
G
--
F
K
M
G
P
F
R
V
S
D
L
A
G
L
D
V
G
W
K
I
R
K
G
Q
GL
T
G
P
S
L
P
P
G
T
---
P
--
V
---
R
K
R
G
N
S
R
Y
-
S
--
P
L
G
D
M
L
C
E
A
G
R
F
G
Q
K
T
G
K
G
W
Y
Q
Y
--
D
K
P
L
G
R
I
H
K
P
D
P
W
L
S
T
F
L
S
Q
Y
R
E
V
H
HI
E
Q
R
T
I
S
K
E
E
I
L
E
R
C
L
Y
S
L
I
N
E
A
F
R
I
L
E
E
G
M
A
A
R
P
E
H
I
D
V
I
Y
L
H
G
Y
G
W
P
R
H
K
G
G
P
M
F
Y
A
------
A
S
------
V
G
L
P
T
V
L
E
K
L
Q
K
Y
---------------------------
20
PsiBlast_PDB
43.15
38%
-78
- C2 -
-
4KUG
1
?
A:
[6-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
D
R
G
I
A
T
I
T
K
S
L
S
K
L
V
A
K
E
K
I
T
E
A
D
K
E
E
-----
I
L
S
R
--
I
S
-
G
T
T
D
M
K
L
A
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
-
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
--
K
L
G
AN
H
P
M
G
P
L
A
L
G
D
L
I
G
L
D
V
C
L
A
-------
I
M
D
V
L
Y
N
E
T
---
G
--
D
----
T
K
Y
R
--
A
-
S
--
S
L
L
R
K
Y
V
R
A
G
W
L
G
R
K
T
G
K
G
F
Y
D
Y
S
K
-------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
32.82
35%
-0
- C2 -
-
3HDH
1
HCDH_PIG
A:
[15-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
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--
I
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-----------
T
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---
H
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---
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