@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VLY5: (2017-11-05 )
MNEQASQNYSFQAEVAQLLHLVTHSLYSNPEIFLRELISNASDACDKLRFEGINHPEYYENDPNLHVRISLNKEDKTLTISDNGIGLSQQEAIDNLGTIAKSGTKDFMSKLTGDQQADAQLIGQFGVGFYSGFIVADKITVESRRAGLDASEGVRWISGGTGEFEVQQIDKASRGTDIILHLRDNALDYLESYKVKQIVNKYSDHISLPIEMQKEVWQEEEAAEGEEPKGGQMVRTDEWEAINSASALWTRNKSEVTEEQYVEFYKNLTHDFEAPLAWAHNRVEGSTEYTQLLYIPSKAPHDIFTREAKAGIKLYVKRVFIMDDADNLIPNYLRFVQGVVDSADLPLNVSRELLQESRDVKTIREGNARRVLTLLDGLAKSEDEKDQEKFKTFYTEFGSVLKEGLGEDFGNRERILKLLRYATSTNDEVTTSFADYKARMKEGQKAIYYVTAESLAAAKNSPQLELFKKKGIEVLLMAERVDEWAMNFVHEFDGTPLKNVSKGAVDLGDLQDAEEKKALEQAAEQFKPVVEKLSDSLKAKTKEVRVTTRLVDSPACLVTSEGELSPQLIRMLKQAGQAVPEIKPILEINPEHPLVKKLEGSEQFDDLANVIFDQAVIAEGGLPEDPAAYVKRINSLLLK
Atome Classification :
(88 SA)
.........10........20........30........40........50....--------....60........70........80........90........100.......110.......120.......130.......140.......150.......160....---.--..-------170-..--.......180.......190.......200.......210----.........220.......230.....--------..240.......250.......260.......270.......280.......290.......300..-..--...310........320.......330.......340.......350.......360.......370.......380.......390.......400...---...--.410.......420...-.--..-.--430.......440.......450.......460.......470.......480.......490.......500.......510...---....520.......530...-.-...540.......550.......560.......570...-......---------580-------.--------.......590......-------.600---..---...-------....610--.........620.......630.......----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNEQASQNY
S
F
Q
A
E
V
A
Q
L
L
H
L
V
T
H
S
LYS
N
P
E
I
F
L
R
E
L
I
SN
A
S
D
A
C
D
K
L
R
FEGINH--------
P
E
Y
YENDP
N
L
H
V
R
I
S
LNKED
K
T
L
T
ISDNGIGL
S
Q
Q
E
A
I
D
N
L
G
T
I
A
KS
G
T
K
D
F
M
S
K
LTGD
Q
Q
A
D
A
Q
L
I
G
Q
F
G
V
G
F
YS
G
F
I
V
A
D
K
I
T
V
E
S
R
RAGL
D
A
S
EG
V
R
W
ISGGTG
E
F
E
V
---
Q
--
Q
I-------D---KA--SRG
T
D
I
I
L
H
LRD
N
A
L
D
Y
L
E
S
Y
K
V
K
Q
I
V
N
K
YSDHISL
P
I
------
E
M
Q
K
E
V
W
Q
E
E
EAAEGEEPKGG
Q
M
V
RTD--------
E
W
EAINS
A
S
A
LWTR
N
K
S
EV
T
E
E
Q
Y
V
E
F
Y
K
N
L
T
H
DFEA
P
L
A
W
AHNRVEGST
E
Y
T
Q
L
L
Y
IPSKAPH
D
I
F
-
T
R
--
E
A
KAG-
I
K
L
Y
V
K
R
V
F
I
MDD
A
D
N
L
I
P
N
Y
L
R
F
V
Q
G
V
VDSADLP
L
N
V
S
R
E
L
L
Q
ESRD
V
K
T
I
REGN
A
R
R
V
L
T
L
L
D
G
LAKSE
D
E
K
D
Q
E
K
F
K
T
F
Y
T
E
F
G
S
V
L
K
E
G
L---GED--FG
N
R
E
R
I
L
K
L
L
R
Y
ATST-N--D
E
-
V
--
T
T
S
F
A
D
Y
K
A
R
M
KEG
Q
K
A
I
Y
Y
V
T
A
E
S
L
AAAKNS
P
Q
L
E
L
F
K
KKG
I
E
V
L
L
M
A
E
R
V
D
E
W
A
M
N
F
V
H
E
FDGTPLKNVSKGAVDLGDLQ
D
A
E
E
---
K
K
A
L
E
Q
A
A
E
Q
F
K
P
V
V
E
K
L
S
D
-
S
-
L
KAKT
K
E
V
R
V
T
T
R
LVDSP
A
C
L
V
TSEGEL
S
P
Q
L
I
R
--
M
L
K
-
Q
AGQAV---------PE--------I--------KP
I
L
EINPEH
P
L
V
K
KL-------EG-----
S
E
---
Q
F
D
-------
D
L
A
N
V
----
I
F
D
Q
A
V
IAEGGLPE
D
P
A
A
Y
V
K
R
I
N
S
L
LLK----
21
PsiBlast_CBE
81.31
52%
-33
- C3 -
-
2IOP
1
HTPG_ECOLI
D:
[2-623]
---
K
G
Q
E
T
R
G
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
--------
P
D
L
Y
E
G
D
G
E
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
L
E
S
L
G
S
D
Q
A
K
D
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
G
E
K
P
E
N
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
---
A
--
D
I
-------
T
---
K
E
--
D
R
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
------
E
I
E
K
-----------
R
E
E
K
D
--
T
V
I
S
----------
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
W
D
M
W
-
N
R
---
H
K
H
G
-
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
----
D
A
E
K
Y
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
---
A
E
D
--
F
A
N
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
-
T
--
D
S
-
S
A
Q
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
K
V
D
E
S
L
E
K
L
---------------------
F
I
D
R
V
K
A
-
L
-
L
G
E
R
V
K
D
V
R
L
T
H
R
L
T
D
T
P
A
I
V
S
T
D
A
D
E
M
S
T
Q
M
A
K
--
L
F
A
-
A
A
G
Q
K
V
---------
P
E
--------
V
--------
K
Y
I
F
E
L
N
P
D
H
V
L
V
K
R
A
-------
A
D
-----
T
E
D
E
A
K
F
S
-------
E
W
V
E
L
----
L
L
D
Q
A
L
L
A
E
R
G
T
L
E
D
P
N
L
F
I
R
R
M
N
Q
L
L
V
-----
1
PsiBlast_PDB
77.43
52%
-35
- C3 -
-
2IOQ
-
HTPG_ECOLI
A:
[15-623]
----------------
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
--------
P
D
L
Y
E
G
D
G
E
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
---------------
K
D
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
G
E
K
P
E
N
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
---
A
--
D
I
-------
T
---
K
E
--
D
R
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
------
E
I
E
K
-----------
R
E
E
K
D
G
E
T
V
I
S
----------
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
W
D
M
W
-
N
R
--
D
H
K
H
G
-
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
----
D
A
E
K
Y
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
---
A
E
D
--
F
A
N
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
-
T
--
D
S
-
S
AQ
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
K
V
D
E
S
L
E
K
L
A
-----------
K
E
A
E
K
A
L
T
P
F
I
D
R
V
K
A
-
L
-
L
G
E
R
V
K
D
V
R
L
T
H
R
L
T
D
T
P
A
I
V
S
T
D
A
-------------------------------------------------
K
Y
I
F
E
L
N
P
D
H
V
L
V
K
R
A
-------
A
D
-----
T
E
D
E
A
K
F
S
-------
E
W
V
E
L
----
L
L
D
Q
A
L
L
A
E
R
G
T
L
E
D
P
N
L
F
I
R
R
M
N
Q
L
L
V
-----
22
PsiBlast_CBE
73.91
55%
-64
- C3 -
-
1Y4S
1
HTPG_ECOLI
B:
[9-483]
----------
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
--------
P
D
L
Y
E
G
D
G
E
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
L
E
S
--------
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
G
E
K
P
E
N
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
---
A
--
D
I
-------
T
---
K
E
--
D
R
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
------
E
I
E
K
-----------
R
E
E
K
D
G
E
T
V
I
S
----------
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
W
D
M
W
-
N
R
--
D
H
K
H
G
-
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
----
D
A
E
K
Y
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
---
A
E
D
--
F
A
N
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
-
T
--
D
S
-
S
AQ
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
73.75
40%
20
- C3 -
-
5FWK
1
HS90B_HUMAN
B:
[17-687]
-------
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
K
I
D
I
I
P
N
P
Q
E
R
T
L
T
L
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
V
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
AD
H
G
-------
E
---
P
I
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
V
K
E
V
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
Y
L
EK
E
--------------------------KEKYI---
D
Q
E
E
L
N
K
T
K
P
I
W
T
R
N
P
D
D
I
T
Q
E
E
Y
G
E
F
Y
K
S
L
T
N
D
W
E
D
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
R
A
L
L
F
I
P
R
R
A
P
F
D
L
F
E
N
K
--
K
K
K
N
N
-
I
K
L
Y
V
R
R
V
F
I
M
D
S
C
D
E
L
I
P
E
Y
L
N
F
I
R
G
V
V
D
S
E
D
L
P
L
N
I
S
R
E
M
L
Q
Q
S
K
I
L
K
V
I
R
K
N
I
V
K
K
C
L
E
L
F
S
E
L
A
E
-----
D
K
E
N
Y
K
K
F
Y
E
A
F
S
K
N
L
K
L
G
I
---
H
E
D
--
S
T
N
R
R
R
L
S
E
L
L
R
Y
H
T
S
Q
-
S
--
G
D
-
E
--
M
T
S
L
S
E
Y
V
S
R
M
K
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Q
V
A
N
S
A
F
V
E
R
V
R
K
R
G
F
E
V
V
Y
M
T
E
P
I
D
E
Y
C
V
Q
Q
L
K
E
F
D
G
K
S
L
V
S
V
T
K
E
G
L
E
L
--
P
E
D
E
E
E
---
K
K
K
M
E
E
S
K
A
K
F
E
N
L
C
K
L
M
K
E
-
I
-
L
D
K
K
V
E
K
V
T
I
S
N
R
L
V
S
S
P
C
C
I
V
T
S
T
Y
G
W
T
A
N
M
E
R
--
I
M
K
---
A
Q
A
L
---------
R
D
NSTMGYMM
A
--------
K
K
H
L
E
I
N
P
D
H
P
I
V
E
T
L
-------
R
Q
-----
K
A
---
E
A
D
KND
K
A
V
K
D
L
V
V
L
----
L
F
E
T
A
L
L
S
S
G
F
S
L
E
D
P
Q
T
H
S
N
R
I
Y
R
M
I
------
24
PsiBlast_CBE
73.74
40%
21
- C3 -
-
5FWP
1
HS90B_HUMAN
B:
[17-687]
-------
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
K
I
D
I
I
P
N
P
Q
E
R
T
L
T
L
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
V
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
AD
H
G
-------
E
---
P
I
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
V
K
E
V
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
Y
L
EK
E
--------------------------KEKYI---
D
Q
E
E
L
N
K
T
K
P
I
W
T
R
N
P
D
D
I
T
Q
E
E
Y
G
E
F
Y
K
S
L
T
N
D
W
E
D
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
R
A
L
L
F
I
P
R
R
A
P
F
D
L
F
E
N
K
--
K
K
K
N
N
-
I
K
L
Y
V
R
R
V
F
I
M
D
S
C
D
E
L
I
P
E
Y
L
N
F
I
R
G
V
V
D
S
E
D
L
P
L
N
I
S
R
E
M
L
Q
Q
S
K
I
L
K
V
I
R
K
N
I
V
K
K
C
L
E
L
F
S
E
L
A
E
-----
D
K
E
N
Y
K
K
F
Y
E
A
F
S
K
N
L
K
L
G
I
---
H
E
D
--
S
T
N
R
R
R
L
S
E
L
L
R
Y
H
T
S
Q
-
S
--
G
D
-
E
--
M
T
S
L
S
E
Y
V
S
R
M
K
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Q
V
A
N
S
A
F
V
E
R
V
R
K
R
G
F
E
V
V
Y
M
T
E
P
I
D
E
Y
C
V
Q
Q
L
K
E
F
D
G
K
S
L
V
S
V
T
K
E
G
L
E
L
--
P
E
D
E
E
E
---
K
K
K
M
E
E
S
K
A
K
F
E
N
L
C
K
L
M
K
E
-
I
-
L
D
K
K
V
E
K
V
T
I
S
N
R
L
V
S
S
P
C
C
I
V
T
S
T
Y
G
W
T
A
N
M
E
R
--
I
M
K
---
A
Q
A
L
---------
R
D
NSTMGYMM
A
--------
K
K
H
L
E
I
N
P
D
H
P
I
V
E
T
L
-------
R
Q
-----
K
A
---
E
A
D
KND
K
A
V
K
D
L
V
V
L
----
L
F
E
T
A
L
L
S
S
G
F
S
L
E
D
P
Q
T
H
S
N
R
I
Y
R
M
I
------
25
PsiBlast_CBE
73.68
40%
21
- C3 -
-
5FWM
1
HS90B_HUMAN
B:
[17-687]
-------
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
K
I
D
I
I
P
N
P
Q
E
R
T
L
T
L
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
V
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
AD
H
G
-------
E
---
P
I
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
V
K
E
V
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
Y
L
EK
E
--------------------------KEKYI---
D
Q
E
E
L
N
K
T
K
P
I
W
T
R
N
P
D
D
I
T
Q
E
E
Y
G
E
F
Y
K
S
L
T
N
D
W
E
D
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
R
A
L
L
F
I
P
R
R
A
P
F
D
L
F
E
N
K
--
K
K
K
N
N
-
I
K
L
Y
V
R
R
V
F
I
M
D
S
C
D
E
L
I
P
E
Y
L
N
F
I
R
G
V
V
D
S
E
D
L
P
L
N
I
S
R
E
M
L
Q
Q
S
K
I
L
K
V
I
R
K
N
I
V
K
K
C
L
E
L
F
S
E
L
A
E
-----
D
K
E
N
Y
K
K
F
Y
E
A
F
S
K
N
L
K
L
G
I
---
H
E
D
--
S
T
N
R
R
R
L
S
E
L
L
R
Y
H
T
S
Q
-
S
--
G
D
-
E
--
M
T
S
L
S
E
Y
V
S
R
M
K
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Q
V
A
N
S
A
F
V
E
R
V
R
K
R
G
F
E
V
V
Y
M
T
E
P
I
D
E
Y
C
V
Q
Q
L
K
E
F
D
G
K
S
L
V
S
V
T
K
E
G
L
E
L
--
P
E
D
E
E
E
---
K
K
K
M
E
E
S
K
A
K
F
E
N
L
C
K
L
M
K
E
-
I
-
L
D
K
K
V
E
K
V
T
I
S
N
R
L
V
S
S
P
C
C
I
V
T
S
T
Y
G
W
T
A
N
M
E
R
--
I
M
K
---
A
Q
A
L
---------
R
D
NSTMGYMM
A
--------
K
K
H
L
E
I
N
P
D
H
P
I
V
E
T
L
-------
R
Q
-----
K
A
---
E
A
D
KND
K
A
V
K
D
L
V
V
L
----
L
F
E
T
A
L
L
S
S
G
F
S
L
E
D
P
Q
T
H
S
N
R
I
Y
R
M
I
------
26
PsiBlast_CBE
73.37
40%
20
- C3 -
-
5FWL
1
HS90B_HUMAN
B:
[17-687]
-------
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
K
I
D
I
I
P
N
P
Q
E
R
T
L
T
L
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
V
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
AD
H
G
-------
E
---
P
I
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
V
K
E
V
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
Y
L
EK
E
--------------------------KEKYI---
D
Q
E
E
L
N
K
T
K
P
I
W
T
R
N
P
D
D
I
T
Q
E
E
Y
G
E
F
Y
K
S
L
T
N
D
W
E
D
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
R
A
L
L
F
I
P
R
R
A
P
F
D
L
F
E
N
K
--
K
K
K
N
N
-
I
K
L
Y
V
R
R
V
F
I
M
D
S
C
D
E
L
I
P
E
Y
L
N
F
I
R
G
V
V
D
S
E
D
L
P
L
N
I
S
R
E
M
L
Q
Q
S
K
I
L
K
V
I
R
K
N
I
V
K
K
C
L
E
L
F
S
E
L
A
E
-----
D
K
E
N
Y
K
K
F
Y
E
A
F
S
K
N
L
K
L
G
I
---
H
E
D
--
S
T
N
R
R
R
L
S
E
L
L
R
Y
H
T
S
Q
-
S
--
G
D
-
E
--
M
T
S
L
S
E
Y
V
S
R
M
K
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Q
V
A
N
S
A
F
V
E
R
V
R
K
R
G
F
E
V
V
Y
M
T
E
P
I
D
E
Y
C
V
Q
Q
L
K
E
F
D
G
K
S
L
V
S
V
T
K
E
G
L
E
L
--
P
E
D
E
E
E
---
K
K
K
M
E
E
S
K
A
K
F
E
N
L
C
K
L
M
K
E
-
I
-
L
D
K
K
V
E
K
V
T
I
S
N
R
L
V
S
S
P
C
C
I
V
T
S
T
Y
G
W
T
A
N
M
E
R
--
I
M
K
---
A
Q
A
L
---------
R
D
NSTMGYMM
A
--------
K
K
H
L
E
I
N
P
D
H
P
I
V
E
T
L
-------
R
Q
-----
K
A
---
E
A
D
KND
K
A
V
K
D
L
V
V
L
----
L
F
E
T
A
L
L
S
S
G
F
S
L
E
D
P
Q
T
H
S
N
R
I
Y
R
M
I
------
2
PsiBlast_PDB
73.33
55%
-65
- C3 -
-
1Y4S
1
HTPG_ECOLI
A:
[9-483]
----------
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
--------
P
D
L
Y
E
G
D
G
E
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
L
E
S
--------
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
G
E
K
P
E
N
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
---
A
--
D
I
-------
T
---
K
E
--
D
R
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
------
E
I
E
K
-----------
R
E
E
K
D
G
E
T
V
I
S
----------
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
W
D
M
W
-
N
R
--
D
H
K
H
G
-
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
----
D
A
E
K
Y
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
---
A
E
D
--
F
A
N
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
-
T
--
D
S
-
S
AQ
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.30
55%
-61
- C3 -
-
1Y4U
-
HTPG_ECOLI
A:
[9-489]
----------
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
--------
P
D
L
Y
E
G
D
G
E
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
-----------------
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
G
E
K
P
E
N
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
---
A
--
D
I
-------
T
---
K
E
--
D
R
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
------
E
I
E
K
-----------
R
E
E
K
D
G
E
T
V
I
S
----------
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
W
D
M
W
-
N
R
--
D
H
K
H
G
-
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
D
----
D
A
E
K
Y
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
---
A
E
D
--
F
A
N
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
-
T
--
D
S
-
S
AQ
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
K
V
D
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.97
34%
-45
- C3 -
-
4J0B
1
?
A:
[31-642]
--------
H
E
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
G
S
D
A
L
E
K
L
R
H
R
M
I
T
A
--------
G
G
---
D
T
A
P
M
E
I
H
L
Q
T
D
S
V
K
G
T
F
T
I
Q
D
T
G
V
G
M
N
K
E
D
L
V
S
N
L
G
T
I
A
R
S
G
S
K
A
F
L
D
A
L
Q
N
Q
A
E
A
S
S
S
I
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
K
V
E
V
Y
S
Q
S
A
E
A
D
A
P
-
G
Y
K
W
S
S
D
G
S
G
V
F
E
V
---
A
--
E
A
-------
S
---
G
V
--
R
Q
G
T
K
I
V
L
H
L
K
D
D
C
K
E
F
S
S
E
D
R
V
K
E
V
V
T
K
Y
S
N
F
V
S
F
P
I
------
F
L
N
G
---------------------------------
R
R
L
N
T
L
Q
A
L
W
M
M
E
P
K
D
I
S
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
Y
D
K
P
R
Y
T
L
H
Y
R
A
D
A
P
L
N
I
R
S
I
F
Y
V
P
E
M
K
P
----------
M
G
S
S
-
V
A
L
Y
S
R
K
I
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
L
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
L
L
Q
E
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
V
I
R
F
L
L
D
Q
S
K
----
K
D
P
E
K
Y
A
R
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
T
G
E
Q
---
S
V
K
E
D
I
A
K
L
L
R
F
E
S
S
A
-
L
--
P
A
G
Q
--
Q
T
S
L
M
E
Y
S
S
R
M
K
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
F
E
A
M
K
--
D
M
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
R
K
K
L
I
S
A
E
T
----------------
R
L
S
S
E
Q
A
E
D
----
L
L
A
W
M
R
N
-
A
-
L
V
Q
R
V
T
N
I
K
V
T
P
R
L
D
T
H
P
A
M
I
T
V
L
E
M
G
A
A
R
H
F
L
R
TQ-------------------
Q
I
--------
L
--------
Q
P
T
L
E
I
N
T
G
H
D
L
I
K
K
L
-------
H
A
-----
L
K
---
D
S
N
P
------
E
L
A
Q
L
L
L
E
Q
I
Y
D
N
A
M
I
A
-
A
G
L
N
E
D
P
R
P
M
I
S
R
L
N
Q
L
L
T
R
----
6
PsiBlast_PDB
70.97
40%
40
- C3 -
-
5FWL
1
HS90B_HUMAN
A:
[17-687]
-------
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
K
I
D
I
I
P
N
P
Q
E
R
T
L
T
L
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
V
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
A
D
H
G
-------
E
---
P
I
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
V
K
E
V
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
YLEK
E
R
E
K
E
I
S
--------------------KKIKEKYI
D
Q
E
E
L
N
K
T
K
P
I
W
T
R
N
P
D
D
I
T
Q
E
E
Y
G
E
F
Y
K
S
L
T
N
D
W
E
D
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
R
A
L
L
F
I
P
R
R
A
P
F
D
L
F
E
N
K
--
K
K
K
N
N
-
I
K
L
Y
V
R
R
V
F
I
M
D
S
C
D
E
L
I
P
E
Y
L
N
F
I
R
G
V
V
D
S
E
D
L
P
L
N
I
S
R
E
M
L
Q
Q
S
K
I
L
K
V
I
R
K
N
I
V
K
K
C
L
E
L
F
S
E
L
A
E
-----
D
K
E
N
Y
K
K
F
Y
E
A
F
S
K
N
L
K
L
G
I
---
H
E
D
--
S
T
N
R
R
R
L
S
E
L
L
R
Y
H
T
S
Q
-
S
--
G
D
-
E
--
M
T
S
L
S
E
Y
V
S
R
M
K
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Q
V
A
N
S
A
F
V
E
R
V
R
K
R
G
F
E
V
V
Y
M
T
E
P
I
D
E
Y
C
V
Q
Q
L
K
E
F
D
G
K
S
L
V
S
V
T
K
E
G
L
E
L
--
P
E
D
E
E
E
---
K
K
K
M
E
E
S
K
A
K
F
E
N
L
C
K
L
M
K
E
-
I
-
L
D
K
K
V
E
K
V
T
I
S
N
R
L
V
S
S
P
C
C
I
V
T
S
T
Y
G
W
T
A
N
M
E
R
--
I
M
K
---
A
Q
A
L
---------
R
D
N
S
T
M
G
Y
M
M
A
--------
K
K
H
L
E
I
N
P
D
H
P
I
V
E
T
L
-------
R
Q
-----
K
A
---
E
A
D
KND
K
A
V
K
D
L
V
V
L
----
L
F
E
T
A
L
L
S
S
G
F
S
L
E
D
P
Q
T
H
S
N
R
I
Y
R
M
I
------
7
PsiBlast_PDB
70.78
40%
39
- C3 -
-
5FWM
1
HS90B_HUMAN
A:
[17-687]
-------
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
K
I
D
I
I
P
N
P
Q
E
R
T
L
T
L
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
V
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
A
D
H
G
-------
E
---
P
I
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
V
K
E
V
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
Y
L
EK
E
R
E
K
E
I
S
--------------------KKIKEKYI
D
Q
E
E
L
N
K
T
K
P
I
W
T
R
N
P
D
D
I
T
Q
E
E
Y
G
E
F
Y
K
S
L
T
N
D
W
E
D
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
R
A
L
L
F
I
P
R
R
A
P
F
D
L
F
E
N
K
--
K
K
K
N
N
-
I
K
L
Y
V
R
R
V
F
I
M
D
S
C
D
E
L
I
P
E
Y
L
N
F
I
R
G
V
V
D
S
E
D
L
P
L
N
I
S
R
E
M
L
Q
Q
S
K
I
L
K
V
I
R
K
N
I
V
K
K
C
L
E
L
F
S
E
L
A
E
-----
D
K
E
N
Y
K
K
F
Y
E
A
F
S
K
N
L
K
L
G
I
---
H
E
D
--
S
T
N
R
R
R
L
S
E
L
L
R
Y
H
T
S
Q
-
S
--
G
D
-
E
--
M
T
S
L
S
E
Y
V
S
R
M
K
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Q
V
A
N
S
A
F
V
E
R
V
R
K
R
G
F
E
V
V
Y
M
T
E
P
I
D
E
Y
C
V
Q
Q
L
K
E
F
D
G
K
S
L
V
S
V
T
K
E
G
L
E
L
--
P
E
D
E
E
E
---
K
K
K
M
E
E
S
K
A
K
F
E
N
L
C
K
L
M
K
E
-
I
-
L
D
K
K
V
E
K
V
T
I
S
N
R
L
V
S
S
P
C
C
I
V
T
S
T
Y
G
W
T
A
N
M
E
R
--
I
M
K
---
A
Q
A
L
---------
R
D
N
S
T
M
G
Y
M
M
A
--------
K
K
H
L
E
I
N
P
D
H
P
I
V
E
T
L
-------
R
Q
-----
K
A
---
E
A
D
KND
K
A
V
K
D
L
V
V
L
----
L
F
E
T
A
L
L
S
S
G
F
S
L
E
D
P
Q
T
H
S
N
R
I
Y
R
M
I
------
8
PsiBlast_PDB
70.72
40%
42
- C3 -
-
5FWP
1
HS90B_HUMAN
A:
[17-687]
-------
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
K
I
D
I
I
P
N
P
Q
E
R
T
L
T
L
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
V
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
A
D
H
G
-------
E
---
P
I
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
V
K
E
V
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
Y
L
EK
E
R
E
K
E
I
S
--------------------KKIKEKYI
D
Q
E
E
L
N
K
T
K
P
I
W
T
R
N
P
D
D
I
T
Q
E
E
Y
G
E
F
Y
K
S
L
T
N
D
W
E
D
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
R
A
L
L
F
I
P
R
R
A
P
F
D
L
F
E
N
K
--
K
K
K
N
N
-
I
K
L
Y
V
R
R
V
F
I
M
D
S
C
D
E
L
I
P
E
Y
L
N
F
I
R
G
V
V
D
S
E
D
L
P
L
N
I
S
R
E
M
L
Q
Q
S
K
I
L
K
V
I
R
K
N
I
V
K
K
C
L
E
L
F
S
E
L
A
E
-----
D
K
E
N
Y
K
K
F
Y
E
A
F
S
K
N
L
K
L
G
I
---
H
E
D
--
S
T
N
R
R
R
L
S
E
L
L
R
Y
H
T
S
Q
-
S
--
G
D
-
E
--
M
T
S
L
S
E
Y
V
S
R
M
K
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Q
V
A
N
S
A
F
V
E
R
V
R
K
R
G
F
E
V
V
Y
M
T
E
P
I
D
E
Y
C
V
Q
Q
L
K
E
F
D
G
K
S
L
V
S
V
T
K
E
G
L
E
L
--
P
E
D
E
E
E
---
K
K
K
M
E
E
S
K
A
K
F
E
N
L
C
K
L
M
K
E
-
I
-
L
D
K
K
V
E
K
V
T
I
S
N
R
L
V
S
S
P
C
C
I
V
T
S
T
Y
G
W
T
A
N
M
E
R
--
I
M
K
---
A
Q
A
L
---------
R
D
N
S
T
M
G
Y
M
M
A
--------
K
K
H
L
E
I
N
P
D
H
P
I
V
E
T
L
-------
R
Q
-----
K
A
---
E
A
D
KND
K
A
V
K
D
L
V
V
L
----
L
F
E
T
A
L
L
S
S
G
F
S
L
E
D
P
Q
T
H
S
N
R
I
Y
R
M
I
------
30
PsiBlast_CBE
70.52
36%
-77
- C3 -
-
4Z1I
1
TRAP1_HUMAN
C:
[25-491]
----
S
T
S
K
H
E
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
A
S
D
A
L
E
K
L
R
H
K
L
V
S
D
--------
G
Q
A
L
---
P
E
M
E
I
H
L
Q
T
N
A
E
K
G
T
I
T
I
Q
D
T
G
I
G
M
T
Q
E
E
L
V
S
N
L
G
T
I
A
R
S
G
S
K
A
F
L
D
A
L
---
A
E
A
S
S
K
I
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
R
V
E
V
Y
S
R
S
A
A
-
P
G
S
L
G
Y
Q
W
L
S
D
G
S
G
V
F
E
I
---
A
--
E
A
-------
S
---
G
V
--
R
T
G
T
K
I
I
I
H
L
K
S
D
C
K
E
F
S
S
E
A
R
V
R
D
V
V
T
K
Y
S
N
F
V
S
F
P
L
------
Y
L
N
----------------
G
R
R
M
-----------------
N
T
L
Q
A
I
W
M
M
D
P
K
D
V
R
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
H
D
K
P
R
Y
T
L
H
Y
K
T
D
A
P
L
N
I
R
S
I
F
Y
V
P
D
M
K
P
------------
S
S
-
V
A
L
Y
S
R
K
V
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
I
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
L
L
Q
E
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
L
I
K
F
F
I
D
Q
S
K
----
K
D
A
E
K
Y
A
K
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
-
A
T
E
--
Q
E
V
K
E
D
I
A
K
L
L
R
Y
E
S
S
A
L
P
--
S
G
-
Q
--
L
T
S
L
S
E
Y
A
S
R
M
R
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
Y
E
A
M
K
K
K
D
T
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
K
K
K
L
I
S
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
70.29
55%
-58
- C3 -
-
1Y4U
-
HTPG_ECOLI
A:
[2-489]
---
K
G
Q
E
T
R
G
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
--------
P
D
L
Y
E
G
D
G
E
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
-----------------
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
G
E
K
P
E
N
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
---
A
--
D
I
-------
T
---
K
E
--
D
R
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
------
E
I
E
K
R
E
E
K
-------------
D
G
E
T
V
I
--------
S
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
W
D
M
W
-
N
R
--
D
H
K
H
G
-
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
M
L
E
K
L
A
K
----
D
D
A
E
K
Y
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
---
A
E
D
--
F
A
N
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
-
T
DS
S
A
-
Q
--
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
K
V
D
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
70.21
40%
42
- C3 -
-
5FWK
1
HS90B_HUMAN
A:
[17-687]
-------
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
K
I
D
I
I
P
N
P
Q
E
R
T
L
T
L
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
V
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
A
D
H
G
-------
E
---
P
I
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
V
K
E
V
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
Y
L
EK
E
R
E
K
E
I
S
--------------------KKIKEKYI
D
Q
E
E
L
N
K
T
K
P
I
W
T
R
N
P
D
D
I
T
Q
E
E
Y
G
E
F
Y
K
S
L
T
N
D
W
E
D
H
L
A
V
K
H
F
S
V
E
G
Q
L
E
F
R
A
L
L
F
I
P
R
R
A
P
F
D
L
F
E
N
K
--
K
K
K
N
N
-
I
K
L
Y
V
R
R
V
F
I
M
D
S
C
D
E
L
I
P
E
Y
L
N
F
I
R
G
V
V
D
S
E
D
L
P
L
N
I
S
R
E
M
L
Q
Q
S
K
I
L
K
V
I
R
K
N
I
V
K
K
C
L
E
L
F
S
E
L
A
E
-----
D
K
E
N
Y
K
K
F
Y
E
A
F
S
K
N
L
K
L
G
I
---
H
E
D
--
S
T
N
R
R
R
L
S
E
L
L
R
Y
H
T
S
Q
-
S
--
G
D
-
E
--
M
T
S
L
S
E
Y
V
S
R
M
K
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
E
Q
V
A
N
S
A
F
V
E
R
V
R
K
R
G
F
E
V
V
Y
M
T
E
P
I
D
E
Y
C
V
Q
Q
L
K
E
F
D
G
K
S
L
V
S
V
T
K
E
G
L
E
L
--
P
E
D
E
E
E
---
K
K
K
M
E
E
S
K
A
K
F
E
N
L
C
K
L
M
K
E
-
I
-
L
D
K
K
V
E
K
V
T
I
S
N
R
L
V
S
S
P
C
C
I
V
T
S
T
Y
G
W
T
A
N
M
E
R
--
I
M
K
---
A
Q
A
L
---------
R
D
N
S
T
M
G
Y
M
M
A
--------
K
K
H
L
E
I
N
P
D
H
P
I
V
E
T
L
-------
R
Q
-----
K
A
---
E
A
D
KND
K
A
V
K
D
L
V
V
L
----
L
F
E
T
A
L
L
S
S
G
F
S
L
E
D
P
Q
T
H
S
N
R
I
Y
R
M
I
------
31
PsiBlast_CBE
70.18
36%
-76
- C3 -
-
4Z1I
1
TRAP1_HUMAN
B:
[25-491]
----
S
T
S
K
H
E
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
A
S
D
A
L
E
K
L
R
H
K
L
V
S
D
--------
G
Q
A
L
---
P
E
M
E
I
H
L
Q
T
N
A
E
K
G
T
I
T
I
Q
D
T
G
I
G
M
T
Q
E
E
L
V
S
N
L
G
T
I
A
R
S
G
S
K
A
F
L
D
A
----
A
E
A
S
S
K
I
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
R
V
E
V
Y
S
R
S
A
A
-
P
G
S
L
G
Y
Q
W
L
S
D
G
S
G
V
F
E
I
---
A
--
E
A
-------
S
---
G
V
--
R
T
G
T
K
I
I
I
H
L
K
S
D
C
K
E
F
S
S
E
A
R
V
R
D
V
V
T
K
Y
S
N
F
V
S
F
P
L
------
Y
L
N
----------------
G
R
R
M
-----------------
N
T
L
Q
A
I
W
M
M
D
P
K
D
V
R
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
H
D
K
P
R
Y
T
L
H
Y
K
T
D
A
P
L
N
I
R
S
I
F
Y
V
P
D
M
K
P
S
M
F
----------
S
-
V
A
L
Y
S
R
K
V
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
I
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
L
L
Q
E
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
L
I
K
F
F
I
D
Q
S
K
----
K
D
A
E
K
Y
A
K
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
-
A
T
E
--
Q
E
V
K
E
D
I
A
K
L
L
R
Y
E
S
S
A
L
P
--
S
G
-
Q
--
L
T
S
L
S
E
Y
A
S
R
M
R
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
Y
E
A
M
K
K
K
D
T
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
K
K
K
L
I
S
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
69.13
36%
-18
- C3 -
-
4J0B
1
?
B:
[27-642]
----
S
F
S
K
H
E
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
G
S
D
A
L
E
K
L
R
H
R
M
I
T
A
--------
G
------
A
P
M
E
I
H
L
Q
T
D
S
V
K
G
T
F
T
I
Q
D
T
G
V
G
M
N
K
E
D
L
V
S
N
L
G
T
I
A
R
S
G
S
K
A
F
L
D
A
L
Q
-----
S
S
S
I
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
K
V
E
V
Y
S
Q
S
A
E
A
D
-
A
P
G
Y
K
W
S
S
D
G
S
G
V
F
E
V
---
A
--
E
A
-------
S
---
G
V
--
R
Q
G
T
K
I
V
L
H
L
K
D
D
C
K
E
F
S
S
E
D
R
V
K
E
V
V
T
K
Y
S
N
F
V
S
F
P
I
------
F
L
N
G
R
---------------------------------
R
L
N
T
L
Q
A
L
W
M
M
E
P
K
D
I
S
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
Y
D
K
P
R
Y
T
L
H
Y
R
A
D
A
P
L
N
I
R
S
I
F
Y
V
P
E
M
K
P
S
-
M
F
-
D
V
S
R
E
M
--
S
-
V
A
L
Y
S
R
K
I
L
I
Q
T
K
--
D
I
L
P
K
W
L
R
F
L
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
L
L
Q
E
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
V
I
R
F
L
L
D
Q
S
K
----
K
D
P
E
K
Y
A
R
F
F
E
D
Y
G
L
F
M
R
E
G
I
---
V
T
T
GE
Q
S
V
K
E
D
I
A
K
L
L
R
F
E
S
S
A
-
L
P-
A
G
-
Q
--
Q
T
S
L
M
E
Y
S
S
R
M
K
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
F
E
A
M
K
Q
K
D
M
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
R
K
K
L
I
S
A
E
T
D
I
V
V
D
H
Y
K
E
E
K
F
Q
D
SK
P
A
S
E
R
L
S
S
E
Q
A
E
D
L
L
A
W
M
R
N
-
A
-
L
V
Q
R
V
T
N
I
K
V
T
P
R
L
D
T
H
P
A
M
I
T
V
L
E
M
G
A
A
R
H
F
L
R
--
T
-------------------
I
--------
L
--------
Q
P
T
L
E
I
N
T
G
H
D
L
I
K
K
L
-------
H
A
L
K
D
S
N
P
E
---
L
A
Q
-------
L
L
L
E
Q
----
I
Y
D
N
A
M
I
A
A
G
L
N
-
E
D
P
R
P
M
I
S
R
L
N
Q
L
L
T
R
----
14
PsiBlast_PDB
67.59
36%
-77
- C3 -
-
4Z1F
1
TRAP1_HUMAN
A:
[25-491]
----
S
T
S
K
H
E
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
A
S
D
A
L
E
K
L
R
H
K
L
V
S
D
--------
G
Q
A
L
---
P
E
M
E
I
H
L
Q
T
N
A
E
K
G
T
I
T
I
Q
D
T
G
I
G
M
T
Q
E
E
L
V
S
N
------------------------------
G
V
G
F
Y
S
A
F
M
V
A
D
R
V
E
V
Y
S
R
S
A
A
-
P
G
S
L
G
Y
Q
W
L
S
D
G
S
G
V
F
E
I
---
A
--
E
A
-------
S
---
G
V
--
R
T
G
T
K
I
I
I
H
L
K
S
D
C
K
E
F
S
S
E
A
R
V
R
D
V
V
T
K
Y
S
N
F
V
S
F
P
L
------
Y
L
N
----------------
G
R
R
M
-----------------
N
T
L
Q
A
I
W
M
M
D
P
K
D
V
R
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
H
D
K
P
R
Y
T
L
H
Y
K
T
D
A
P
L
N
I
R
S
I
F
Y
V
P
D
M
K
P
-------------
S
-
V
A
L
Y
S
R
K
V
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
I
R
G
V
V
D
S
E
D
I
P
----------
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
L
I
K
F
F
I
D
Q
S
K
----
K
D
A
E
K
Y
A
K
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
-
A
T
E
--
Q
E
V
K
E
D
I
A
K
L
L
R
Y
E
S
S
A
L
P
--
S
G
-
Q
--
L
T
S
L
S
E
Y
A
S
R
M
R
A
G
-
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
Y
E
A
M
K
K
K
D
T
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
K
K
K
L
I
S
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
67.48
39%
10
- C3 -
-
2O1V
1
ENPL_CANLF
A:
[34-655]
-----------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
--------
E
N
A
L
A
G
N
E
E
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
----------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
--
N
D
T
Q
H
I
-
W
E
S
-
D
S
N
E
F
S
V
I
A
D
P
--
R
G
-------
N
---
T
L
--
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
----------
Y
V
W
S
S
K
-------------
V
W
----------
D
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
R
-------------Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
A
---
D
E
K
Y
N
D
---
T
F
W
K
E
F
G
T
N
I
K
L
G
V
---
I
E
D
--
H
S
N
R
T
R
L
A
K
L
L
R
F
Q
S
S
H
-
H
--
P
S
-
D
--
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
G
V
K
F
D
E
S
E
K
T
K
E
---
S
R
--
E
A
I
E
K
E
F
E
P
L
L
N
W
M
K
D
K
A
-
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
Y
G
W
S
G
N
M
E
R
--
I
M
K
A
Q
A
Y
Q
T
G
---------
K
D
--------
I
STNYYAS
Q
K
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
R
R
V
K
E
D
E
D
-----
D
K
---
T
V
S
-------
D
L
A
V
V
----
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
------
9
PsiBlast_PDB
67.45
39%
10
- C3 -
-
2O1U
1
?
A:
[34-655]
-----------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
--------
E
N
A
L
A
G
N
E
E
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
----------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
--
N
D
T
Q
H
I
-
W
E
S
-
D
S
N
E
F
S
V
I
A
D
P
--
R
G
-------
N
---
T
L
--
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
----------
Y
V
W
S
S
K
-------------
V
W
----------
D
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
R
-------------Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
A
---
D
E
K
Y
N
D
---
T
F
W
K
E
F
G
T
N
I
K
L
G
V
---
I
E
D
--
H
S
N
R
T
R
L
A
K
L
L
R
F
Q
S
S
H
-
H
--
P
S
-
D
--
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
G
V
K
F
D
E
S
E
K
T
K
E
---
S
R
--
E
A
I
E
K
E
F
E
P
L
L
N
W
M
K
D
K
A
-
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
Y
G
W
S
G
N
M
E
R
--
I
M
K
A
Q
A
Y
Q
T
G
---------
K
D
--------
I
STNYYASQ
K
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
R
R
V
K
E
D
E
D
-----
D
K
---
T
V
S
-------
D
L
A
V
V
----
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
------
136
Fugue
63.43
39%
43
- C3 -
-
2O1U
1
?
A:
[34-661]
-----------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
--------
E
N
A
L
A
G
N
E
E
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
----------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
N
---
D
T
Q
H
I
W
E
S
D
S
N
E
F
S
V
I
---
A
DP
R
G
-------
N
---
T
L
--
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
------
Y
V
W
S
S
-------------------
K
V
W
--------
D
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
R
------------
Y
-
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
A
------
D
E
K
Y
N
D
T
F
W
K
E
F
G
T
N
I
K
L
G
V
---
I
E
D
--
H
S
N
R
T
R
L
A
K
L
L
R
F
Q
S
S
H
-
H
--
P
S
-
D
--
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
K
E
G
V
K
F
D
E
--
S
E
K
T
---
K
E
S
R
E
A
I
E
K
E
F
E
P
L
L
N
W
M
K
D
-
K
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
C
A
L
V
A
S
Q
Y
G
W
S
G
N
M
E
R
--
I
M
K
-
A
Q
A
Y
Q
T
GKDISTNYY
A
S
--------
Q
--------
K
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
L
R
R
V
K
E
D
E
D
-----
D
K
---
T
V
S
-------
D
L
A
V
V
----
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
LNI
41
PsiBlast_CBE
57.70
58%
-85
- C3 -
-
2IOR
3
HTPG_ECOLI
A:
[22-231]
---
K
G
Q
E
T
R
G
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
--------
P
D
L
Y
E
G
D
G
E
L
R
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
L
E
S
L
G
S
D
Q
A
K
D
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
G
E
K
P
E
N
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
---
A
--
D
I
-------
T
---
K
E
--
D
R
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
H
I
A
L
P
V
------
E
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
52.77
45%
-57
- C3 -
-
3C11
3
HSP82_YEAST
A:
[21-232]
---
M
A
S
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
--------
P
K
Q
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
A
A
G
T
K
A
F
M
E
A
L
S
A
--
G
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
---
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
---
T
--
L
D
-------
E
VNE
R
I
--
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
------
Q
L
V
V
T
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
51.89
45%
-52
- C3 -
-
2BYH
1
HS90A_HUMAN
A:
[11-224]
M
E
E
E
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
51.71
45%
-55
- C3 -
-
3T10
1
HS90A_HUMAN
A:
[4-216]
M
E
E
E
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
51.57
45%
-52
- C3 -
-
2BYI
1
HS90A_HUMAN
A:
[11-224]
M
E
E
E
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
51.31
45%
-52
- C3 -
-
4FCR
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
-
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
51.06
45%
-56
- C3 -
-
4L91
1
HS90A_HUMAN
A:
[9-215]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
51.00
46%
-52
* C3 *
-
1AM1
1
HSP82_YEAST
A:
[3-211]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
--------
P
K
Q
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
--
S
A
G
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
---
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
---
T
--
L
D
-------
E
VNE
R
I
--
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
------
Q
L
V
V
T
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
50.91
45%
-47
- C3 -
-
3R4M
1
HS90A_HUMAN
A:
[4-217]
M
E
E
E
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
50.75
47%
-50
- C3 -
-
4GQT
1
HSP90_CAEEL
B:
[6-211]
--
E
N
A
-
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
Y
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
Q
A
L
T
E
--------
P
S
E
L
D
T
G
K
E
L
F
I
K
I
T
P
N
K
E
E
K
T
L
T
I
M
D
T
G
I
G
M
T
K
A
D
L
V
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
F
L
V
A
D
K
V
V
V
T
S
K
N
N
D
D
D
S
---
Y
Q
W
E
S
S
A
G
G
S
F
V
V
---
R
--
P
F
-------
N
DP-
E
V
--
T
R
G
T
K
I
V
M
H
I
K
E
D
Q
I
D
F
L
E
E
R
K
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
50.72
47%
-53
- C3 -
-
4GQT
1
HSP90_CAEEL
A:
[6-211]
--
E
N
A
-
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
Y
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
Q
A
L
T
E
--------
P
S
E
L
D
T
G
K
E
L
F
I
K
I
T
P
N
K
E
E
K
T
L
T
I
M
D
T
G
I
G
M
T
K
A
D
L
V
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
F
L
V
A
D
K
V
V
V
T
S
K
N
N
D
D
D
S
---
Y
Q
W
E
S
S
A
G
G
S
F
V
V
---
R
--
P
F
-------
N
D
P-
E
V
--
T
R
G
T
K
I
V
M
H
I
K
E
D
Q
I
D
F
L
E
E
R
K
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
50.51
45%
-54
- C3 -
-
2BT0
1
HS90A_HUMAN
B:
[15-222]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
50.44
44%
-46
- C3 -
-
3Q5L
2
?
A:
[20-226]
-----
T
E
T
F
A
F
Q
A
E
I
N
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
C
D
K
I
R
Y
Q
S
L
T
D
--------
P
S
V
L
G
E
S
P
R
L
C
I
R
V
V
P
D
K
E
N
K
T
L
T
V
E
D
N
G
I
G
M
T
K
A
D
L
V
N
N
L
G
T
I
A
R
S
G
T
K
A
F
M
E
A
L
--
E
A
G
G
D
M
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
D
R
V
T
V
T
S
K
N
---
N
S
D
E
S
Y
V
W
E
S
S
A
G
G
T
F
T
I
---
T
--
S
--------------M-
K
R
G
T
R
I
T
L
H
L
K
E
D
Q
M
E
Y
L
E
P
R
R
L
K
E
L
I
K
K
H
S
E
F
I
G
Y
D
I
------
E
L
M
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
50.33
45%
-57
- C3 -
-
1UY8
1
HS90A_HUMAN
A:
[17-223]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
50.32
45%
-55
- C3 -
-
1UYK
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
50.26
45%
-56
- C3 -
-
5CF0
1
HS90A_HUMAN
A:
[9-216]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
50.21
45%
-52
- C3 -
-
5FND
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
50.20
45%
-52
- C3 -
-
4U93
1
HS90A_HUMAN
A:
[17-223]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
50.09
45%
-52
- C3 -
-
4W7T
1
HS90A_HUMAN
A:
[17-223]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
50.04
45%
-48
- C3 -
-
3T2S
1
HS90A_HUMAN
A:
[9-219]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
E
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
50.03
44%
-51
- C3 -
-
3Q5J
1
?
A:
[20-226]
-----
T
E
T
F
A
F
Q
A
E
I
N
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
C
D
K
I
R
Y
Q
S
L
T
D
--------
P
-------
R
L
C
I
R
V
V
P
D
K
E
N
K
T
L
T
V
E
D
N
G
I
G
M
T
K
A
D
L
V
N
N
L
G
T
I
A
R
S
G
T
K
A
F
M
E
A
L
--
E
A
G
G
D
M
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
D
R
V
T
V
T
S
K
N
---
N
S
D
E
S
Y
V
W
E
S
S
A
G
G
T
F
T
I
---
T
--
S
T
-------
P
-----M-
K
R
G
T
R
I
T
L
H
L
K
E
D
Q
M
E
Y
L
E
P
R
R
L
K
E
L
I
K
K
H
S
E
F
I
G
Y
D
I
------
E
L
M
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
50.01
45%
-54
- C3 -
-
4L8Z
1
HS90A_HUMAN
A:
[9-216]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
49.97
45%
-50
- C3 -
-
1UYC
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
49.96
45%
-54
- C3 -
-
1UY9
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
49.96
45%
-55
- C3 -
-
4L90
1
HS90A_HUMAN
A:
[9-216]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
49.94
45%
-54
- C3 -
-
5FNC
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
49.91
45%
-50
- C3 -
-
1UYF
1
HS90A_HUMAN
A:
[16-224]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
49.87
45%
-52
- C3 -
-
2BZ5
1
HS90A_HUMAN
A:
[15-224]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
T
G-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
49.84
45%
-51
- C3 -
-
3T0Z
1
HS90A_HUMAN
A:
[4-215]
M
E
E
E
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
49.82
44%
-52
- C3 -
-
2JKI
1
?
B:
[8-219]
--
A
T
E
T
E
T
F
A
F
Q
A
E
I
N
Q
L
L
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
F
E
S
L
T
D
--------
K
S
K
L
D
A
Q
P
E
L
F
I
H
I
I
P
D
K
A
T
S
T
L
T
I
V
D
S
G
I
G
M
T
K
S
D
L
V
N
N
L
G
T
I
A
R
S
G
T
K
E
F
M
E
A
L
A
A
--
G
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
R
V
V
V
T
T
K
H
N
D
D
---
E
Q
Y
V
W
E
S
Q
A
G
G
S
F
T
V
---
T
--
R
D
-------
T
SGE
Q
L
--
G
R
G
T
K
M
V
L
Y
L
K
D
D
Q
M
E
Y
L
E
E
R
R
I
K
D
L
V
K
R
H
S
E
F
I
S
Y
P
I
------
S
L
W
T
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
49.80
45%
-51
- C3 -
-
1UYD
1
HS90A_HUMAN
A:
[16-224]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
49.62
45%
-52
- C3 -
-
2WI7
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
49.56
45%
-57
- C3 -
-
2WI2
1
HS90A_HUMAN
B:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
49.40
44%
-49
- C3 -
-
3Q5L
2
?
B:
[20-226]
-----
T
E
T
F
A
F
Q
A
E
I
N
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
C
D
K
I
R
Y
Q
S
L
T
D
--------
P
S
V
L
G
E
S
P
R
L
C
I
R
V
V
P
D
K
E
N
K
T
L
T
V
E
D
N
G
I
G
M
T
K
A
D
L
V
N
N
L
G
T
I
A
R
S
G
T
K
A
F
M
E
A
L
--
E
A
G
G
D
M
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
D
R
V
T
V
T
S
K
N
---
N
S
D
E
S
Y
V
W
E
S
S
A
G
G
T
F
T
I
---
T
--
S
T
-------
P
---
E
S
DM
K
R
G
T
R
I
T
L
H
L
K
E
D
Q
M
E
Y
L
E
P
R
R
L
K
E
L
I
K
K
H
S
E
F
I
G
Y
D
I
------
E
L
M
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
49.36
45%
-51
- C3 -
-
2BT0
1
HS90A_HUMAN
A:
[15-222]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
49.35
44%
-52
- C3 -
-
3H80
8
?
A:
[20-226]
-----
T
E
T
F
A
F
Q
A
E
I
N
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
C
D
K
I
R
Y
Q
S
L
T
D
--------
P
S
V
L
G
E
S
P
R
L
C
I
R
V
V
P
D
K
E
N
K
T
L
T
V
E
D
N
G
I
G
M
T
K
A
D
L
V
N
N
L
G
T
I
A
R
S
G
T
K
A
F
M
E
A
L
--
E
A
G
G
D
M
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
D
R
V
T
V
T
S
K
N
---
N
S
D
E
S
Y
V
W
E
S
S
A
G
G
T
F
T
I
---
T
--
S
T
-------
P
---
E
S
DM
K
R
G
T
R
I
T
L
H
L
K
E
D
Q
M
E
Y
L
E
P
R
R
L
K
E
L
I
K
K
H
S
E
F
I
G
Y
D
I
------
E
L
M
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
49.26
45%
-53
- C3 -
-
2VCJ
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
49.25
45%
-53
- C3 -
-
1UYH
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
49.23
45%
-47
- C3 -
-
3T1K
1
HS90A_HUMAN
A:
[9-221]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
E
R
D
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
49.23
45%
-52
- C3 -
-
4L93
1
HS90A_HUMAN
A:
[9-215]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
49.21
45%
-57
- C3 -
-
4L94
1
HS90A_HUMAN
A:
[9-215]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
49.19
45%
-50
- C3 -
-
2WI1
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
49.14
45%
-51
- C3 -
-
3T2S
1
HS90A_HUMAN
B:
[9-219]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
E
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
49.11
45%
-56
- C3 -
-
4HY6
1
HS90A_HUMAN
A:
[9-216]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
49.10
44%
-48
- C3 -
-
3Q5L
1
?
D:
[20-226]
-----
T
E
T
F
A
F
Q
A
E
I
N
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
C
D
K
I
R
Y
Q
S
L
T
D
--------
P
S
V
L
G
E
S
P
R
L
C
I
R
V
V
P
D
K
E
N
K
T
L
T
V
E
D
N
G
I
G
M
T
K
A
D
L
V
N
N
L
G
T
I
A
R
S
G
T
K
A
F
M
E
A
L
--
E
A
G
G
D
M
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
D
R
V
T
V
T
S
K
N
---
N
S
D
E
S
Y
V
W
E
S
S
A
G
G
T
F
T
I
---
T
--
S
T
-------
P
---
E
S
DM
K
R
G
T
R
I
T
L
H
L
K
E
D
Q
M
E
Y
L
E
P
R
R
L
K
E
L
I
K
K
H
S
E
F
I
G
Y
D
I
------
E
L
M
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
49.09
45%
-51
- C3 -
-
2WI6
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
49.02
45%
-48
- C3 -
-
4L93
1
HS90A_HUMAN
B:
[9-215]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
48.90
45%
-49
- C3 -
-
2UWD
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
48.90
45%
-50
- C3 -
-
2VCI
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
48.84
45%
-48
- C3 -
-
4FCQ
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
T
G
-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
48.82
45%
-54
- C3 -
-
4FCP
1
HS90A_HUMAN
B:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
48.79
45%
-58
- C3 -
-
2WI4
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
48.69
45%
-50
- C3 -
-
2BSM
1
HS90A_HUMAN
A:
[15-222]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
48.67
45%
-43
- C3 -
-
3T1K
1
HS90A_HUMAN
B:
[8-221]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
E
R
D
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
48.65
45%
-51
- C3 -
-
2WI3
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
48.59
45%
-50
- C3 -
-
1UYE
1
HS90A_HUMAN
A:
[16-224]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
48.40
44%
-45
- C3 -
-
3Q5L
2
?
C:
[20-226]
-----
T
E
T
F
A
F
Q
A
E
I
N
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
C
D
K
I
R
Y
Q
S
L
T
D
--------
P
S
V
L
G
E
S
P
R
L
C
I
R
V
V
P
D
K
E
N
K
T
L
T
V
E
D
N
G
I
G
M
T
K
A
D
L
V
N
N
L
G
T
I
A
R
S
G
T
K
A
F
M
E
A
L
--
E
A
G
G
D
M
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
D
R
V
T
V
T
S
K
N
---
N
S
D
E
S
Y
V
W
E
S
S
A
G
G
T
F
T
I
---
T
--
S
T
-------
P
---
E
S
DM
K
R
G
T
R
I
T
L
H
L
K
E
D
Q
M
E
Y
L
E
P
R
R
L
K
E
L
I
K
K
H
S
E
F
I
G
Y
D
I
------
E
L
M
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
48.35
45%
-54
- C3 -
-
4FCP
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
T
G-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
48.31
45%
-54
- C3 -
-
1UYG
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
48.26
45%
-46
- C3 -
-
2BZ5
1
HS90A_HUMAN
B:
[15-224]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
48.19
45%
-53
- C3 -
-
2WI2
2
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
48.17
45%
-52
- C3 -
-
1UY7
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
TG-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
47.99
45%
-50
- C3 -
-
2WI5
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
--------
P
S
K
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
A
G
--
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
---
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
---
R
--
T
D
T
G-----
E
---
P
M
--
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
------
T
L
F
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
47.72
44%
-42
- C3 -
-
3U67
4
?
A:
[20-226]
-----
T
E
T
F
A
F
Q
A
E
I
N
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
C
D
K
I
R
Y
Q
S
L
T
D
--------
P
S
V
L
G
E
S
P
R
L
C
I
R
V
V
P
D
K
E
N
K
T
L
T
V
E
D
N
G
I
G
M
T
K
A
D
L
V
N
N
L
G
T
I
A
R
S
G
T
K
A
F
M
E
A
L
--
E
A
G
G
D
M
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
D
R
V
T
V
T
S
K
N
---
N
S
D
E
S
Y
V
W
E
S
S
A
G
G
T
F
T
I
---
T
--
S
T
-------
P
---
E
S
M-
K
R
G
T
R
I
T
L
H
L
K
E
D
Q
M
E
Y
L
E
P
R
R
L
K
E
L
I
K
K
H
S
E
F
I
G
Y
D
I
------
E
L
M
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
46.41
41%
-56
- C3 -
-
3PEH
1
?
B:
[21-234]
---
E
S
M
E
S
H
Q
Y
Q
T
E
V
T
R
L
M
D
I
I
V
N
S
L
Y
T
Q
K
E
V
F
L
R
E
L
I
S
N
A
A
D
A
L
E
K
I
R
F
L
S
L
S
D
--------
E
S
V
L
G
E
E
K
K
L
E
I
R
I
S
A
N
K
E
K
N
I
L
S
I
T
D
T
G
I
G
M
T
K
V
D
L
I
N
N
L
G
T
I
A
K
S
G
T
S
N
F
L
E
A
I
S
K
S
-
G
G
D
M
S
L
I
G
Q
F
G
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
Y
T
K
N
N
D
D
---
E
Q
Y
I
W
E
S
T
A
D
A
K
F
T
I
---
Y
--
K
D
-------
P
RGA
T
L
--
K
R
G
T
R
I
S
L
H
L
K
E
D
A
T
N
L
L
N
D
K
K
L
M
D
L
I
S
K
Y
S
Q
F
I
Q
F
P
I
------
Y
L
L
H
E
N
V
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
35.37
46%
52
- C3 -
-
3IED
1
?
A:
[20-271]
-
Q
G
S
P
V
E
K
Y
N
F
K
A
E
V
N
K
V
M
D
I
I
V
N
S
L
Y
T
D
K
D
V
F
L
R
E
L
I
S
N
A
S
D
A
C
D
K
K
R
I
I
L
E
N
N
K
L
I
K
D
A
EV----
N
D
I
K
K
L
I
I
K
I
K
P
D
K
E
K
K
T
L
T
I
T
D
N
G
I
G
M
D
K
S
E
L
I
N
N
L
G
T
I
A
Q
S
G
T
A
K
F
L
K
Q
I
E
E
-
G
K
A
D
S
N
L
I
G
Q
F
G
V
G
F
Y
S
S
F
L
V
S
N
R
V
E
V
Y
T
K
K
E
D
Q
----
I
Y
R
W
S
S
D
L
K
G
S
F
S
V
---
N
--
E
I
KKYDQEY----
I
K
--
G
S
G
T
K
I
I
L
H
L
K
E
E
C
D
E
Y
L
E
D
Y
K
L
K
E
L
I
K
K
Y
S
E
F
I
K
F
P
I
------
E
I
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------