@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VM07: (2017-11-05 )
MSQANATSLTLSSPTENKTSESGQLKEFRTPPHNLAIEQAVLAALMTVAESFEQVSDLLKENDFYATRHKYIYRAIEKLAQENSPYDAVLVNDWLLKQNLLDAIGGEEYLMQLMADSPSSFYNLETYATKIKEFSTLRSMIKVSTEILQNAYDTKGRGVSEILDLAETSIFSLAEQHNNNKKDSGPKAISSVTADVISKLDELSKLDGNITGLTTGFLELDNKTSGMQPGDLIIVAARPSMGKTTFAMNLVESVLQYNKLPALVFSMEMPADSIAMRLISAMGKVHQGHLRSGNLDADEWTKVTGTILQLQQMHLYIDDSSALPPTEVRARARRIAKMHDGKIGCIMVDYLQLMKVPGMGDNRVGEISEISRSLKALAKEMNCPVIALSQLNRSLENRPNKRPVMSDLRESGAIEQDADLIMFIYRDEVYNKESKEAGTAEIIIGKQRNGPIGTVRLAFEGQYTRFSNLSPEYYNQYDDEE
Atome Classification :
(20 SA)
.........10........20........30........40........50........-60........70........80.-.......90........100.......110..--.....120.......130.......140.......150.......160.......170.......180....-...190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......-360........370.......380.......390.......400.......410.......420.......430.--.-.....440.......450.......460.......470.......480
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSQAN
A
T
S
L
T
LSSPTENKTSESGQLKEFRTPPH
N
L
A
I
E
Q
A
V
L
A
A
L
M
T
V
A
E
S
F
E
Q
V
S
D
L
L
-KEND
F
Y
A
T
R
H
K
Y
I
Y
R
A
I
E
K
L
A
QE-NSPY
D
A
V
L
V
N
D
W
L
L
K
Q
N
L
L
D
AIG
G
E
E
Y
L
M
Q
L
M
--ADSPSSFY
N
L
E
T
Y
A
T
K
I
K
E
F
S
T
L
R
S
M
I
K
V
S
T
E
I
L
Q
N
AYDTKGR
G
V
S
E
I
L
D
L
A
E
T
S
I
F
S
L
A
E
Q
HNNNKKDSG
P
-
K
A
I
S
S
V
T
A
D
V
I
S
K
L
D
E
L
S
K
LDGNITG
L
T
T
G
F
L
E
LDNKTSGMQPG
D
L
I
I
V
AARPSMG
K
T
T
F
A
M
N
L
V
E
S
V
L
Q
YNKL
P
A
L
V
F
S
MEM
P
A
D
S
I
A
M
R
L
I
S
A
M
G
K
V
HQGHLRSGNL
D
A
D
E
W
T
K
V
T
G
T
I
L
Q
L
Q
Q
M
H
L
Y
IDDSSAL
P
P
T
E
V
R
A
R
A
R
R
I
A
K
MHDGK
I
G
C
I
M
V
D
Y
L
Q
L
MKVPGM-G-DNRVG
E
I
S
E
I
S
R
S
L
K
A
L
A
K
EMNCP
V
I
A
L
S
Q
L
N
R
S
L
ENRPNKR
P
V
M
S
D
L
R
ESGAIEQDA
D
L
I
M
F
I
YRDEVYNKE--S-KEAGT
A
E
I
I
I
GKQRNGPI
G
T
V
R
L
A
FEGQYTRFSNL
S
P
E
Y
Y
N
QYDDEE
50
HHSearch
85.55
42%
-87
- C4 -
-
4ESV
2
?
C:
[8-441]
----------------------------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
D
R
-
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
--
D
A
V
P
T
A
-
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
-
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
R
K
----
H
S
G
A
F
-
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
H
N
R
D
G
E
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
R
S
K
-
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
-
E
N
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------------
2
PsiBlast_PDB
82.71
42%
-135
- C4 -
-
2R6E
-
?
A:
[8-441]
----------------------------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
D
R
-
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
---
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
--------------------------------------
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
--
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
R
-----
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
---
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
----------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------------
28
PsiBlast_CBE
82.47
42%
-38
- C4 -
-
4ESV
2
?
C:
[8-441]
----------------------------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
D
R
-
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
---
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
-----
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
H
N
R
D
G
E
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
--
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
R
-
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
-
E
N
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------------
27
PsiBlast_CBE
80.56
42%
-33
- C4 -
-
4ESV
1
?
D:
[8-441]
----------------------------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
D
R
-
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
---
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
-----
R
K
H
--
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
H
N
R
D
G
-
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
--
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
R
-
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
-
E
N
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------------
26
PsiBlast_CBE
79.90
42%
-38
- C4 -
-
4ESV
2
?
F:
[9-441]
-----------------------------
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
D
R
-
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
---
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
-----------
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
--
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
R
-
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
-
E
N
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------------
1
PsiBlast_PDB
79.52
42%
-50
- C4 -
-
2R6A
-
?
A:
[8-441]
----------------------------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
D
R
-
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
---
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
-----
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
H
N
R
D
G
E
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
--
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
R
-----
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
---
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
----------
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------------
3
PsiBlast_PDB
79.26
42%
-37
- C4 -
-
4ESV
2
?
A:
[8-441]
----------------------------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
D
R
-
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
---
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
-----------F
K
N
I
K
D
I
L
V
Q
T
Y
------------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
--
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
R
-
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
-
E
N
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------------
24
PsiBlast_CBE
79.24
42%
-38
- C4 -
-
4ESV
2
?
H:
[9-445]
-----------------------------
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
D
R
-
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
---
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
--------------F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
H
N
R
---
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
--
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
R
-
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
-
E
N
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
E
R
R
F
--------
29
PsiBlast_CBE
79.12
42%
-39
- C4 -
-
4ESV
2
?
B:
[8-445]
----------------------------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
D
R
-
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
---
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
-----
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
H
N
--
G
E
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
--
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
R
-
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
--------
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
-
E
N
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
E
R
R
F
--------
23
PsiBlast_CBE
78.71
42%
-40
- C4 -
-
4ESV
27
?
I:
[9-441]
-----------------------------
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
D
R
-
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
---
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
--------------F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
--
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
R
-
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
-
E
N
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------------
49
HHSearch
78.05
42%
-140
- C4 -
-
2R6A
-
?
B:
[9-441]
-----------------------------
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
D
R
-
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
--
D
A
V
P
T
A
-
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
-
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
R
K
----
H
S
G
A
F
-
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
--------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
-------------
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
-------------------------
D
A
D
I
V
A
F
L
-----------------
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------------
25
PsiBlast_CBE
77.83
42%
-34
- C4 -
-
4ESV
1
?
G:
[8-441]
----------------------------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
D
R
-
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
---
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
------------F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
--
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
R
-
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
-
E
N
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------------
21
PsiBlast_CBE
77.73
42%
-36
- C4 -
-
4ESV
1
?
L:
[10-441]
------------------------------
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
D
R
-
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
---
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
------------
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
--
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
R
-
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
-
E
N
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------------
22
PsiBlast_CBE
76.89
42%
-40
- C4 -
-
4ESV
26
?
J:
[14-441]
----------------------------------
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
D
R
-
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
---
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
-----------F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
--
E
S
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
G
S
G
R
-
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
-
E
N
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
------------
5
PsiBlast_PDB
76.87
43%
-46
- C4 -
-
2VYE
1
?
A:
[9-440]
-----------------------------
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
T
A
L
T
L
A
S
E
R
L
-
I
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
A
D
K
-
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
L
E
Q
L
E
E
V
G
G
V
S
Y
L
S
E
L
---
A
D
S
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
L
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
-
T
R
E
D
E
I
D
V
L
L
D
E
A
E
R
K
I
M
E
V
S
Q
-----
R
K
H
S
G
A
F
K
N
I
K
D
V
L
V
Q
T
Y
D
N
I
E
M
L
H
N
R
N
G
D
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
Q
--
E
S
G
L
G
M
V
V
I
D
Y
L
Q
L
I
Q
G
S
G
R
-
N
R
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
--
P
M
M
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
--
N
K
D
--
S
-
E
N
K
N
I
I
E
I
I
I
A
K
Q
R
N
G
----
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
-------------
52
HHSearch
76.12
40%
-15
- C4 -
-
4NMN
1
?
A:
[2-433]
-------------------------------
P
C
D
E
S
A
E
R
A
V
L
G
S
M
L
E
D
P
E
N
I
P
L
V
L
E
Y
L
-
K
E
E
D
F
C
I
D
E
H
K
L
L
F
R
V
L
T
N
L
W
S
E
Y
G
N
K
L
D
F
V
L
I
K
D
H
L
E
K
K
N
L
L
Q
----
I
D
W
L
E
E
L
Y
--
E
E
A
V
S
P
-
D
T
L
E
E
V
C
K
I
V
K
Q
R
S
A
Q
R
A
I
I
Q
L
G
I
E
L
I
H
K
G
K
E
N
--
K
D
F
H
T
L
I
E
E
A
Q
S
R
I
F
S
I
A
E
S
------
S
T
Q
F
-
Y
H
V
K
D
V
A
E
E
V
I
E
L
I
Y
K
F
K
S
S
D
R
L
V
T
G
L
P
S
G
F
T
E
L
D
L
K
T
T
G
F
H
P
G
D
L
I
I
L
A
A
R
P
G
M
G
K
T
A
F
M
L
S
I
I
Y
N
L
A
K
D
E
G
K
P
S
A
V
F
S
L
E
M
S
K
E
Q
L
V
M
R
L
L
S
M
M
S
E
V
P
L
F
K
I
R
S
G
S
I
S
N
E
D
L
K
K
L
E
A
S
A
I
E
L
A
K
Y
D
I
Y
L
D
D
T
P
A
L
T
T
T
D
L
R
I
R
A
R
K
L
R
K
E
K
--
E
V
E
F
V
A
V
D
Y
L
Q
L
L
R
P
P
V
R
-
K
-
S
P
R
Q
E
E
V
A
E
V
S
R
N
L
K
A
L
A
K
E
L
R
I
P
V
M
A
L
A
Q
L
S
R
E
V
E
K
R
S
D
K
R
P
Q
L
A
D
L
R
E
S
G
Q
I
E
Q
D
A
D
L
I
L
F
L
H
R
P
E
Y
Y
T
K
K
--
P
N-
E
Q
G
I
A
E
V
I
I
A
K
Q
R
Q
G
P
T
D
I
V
K
L
A
F
I
K
E
Y
T
K
F
A
N
L
E
-----------
51
HHSearch
75.18
40%
-92
- C4 -
-
4NMN
2
?
B:
[2-432]
-------------------------------
P
C
D
E
S
A
E
R
A
V
L
G
S
M
L
E
D
P
E
N
I
P
L
V
L
E
Y
L
-
K
E
E
D
F
C
I
D
E
H
K
L
L
F
R
V
L
T
N
L
W
S
E
-
G
N
K
L
D
F
V
L
I
K
D
H
L
E
K
K
-------
P
I
D
W
L
E
E
L
Y
--
E
E
A
V
S
P
-
D
T
L
E
E
V
C
K
I
V
K
Q
R
S
A
Q
R
A
I
I
Q
L
G
I
E
L
I
H
K
G
K
E
N
--
K
D
F
H
T
L
I
E
E
A
Q
S
R
I
F
S
I
A
E
S
A
----
T
S
T
Q
F
-
Y
H
V
K
D
V
A
E
E
V
I
E
L
I
Y
K
F
K
S
S
D
R
L
V
T
G
L
P
S
G
F
T
E
L
D
L
K
T
T
G
F
H
P
G
D
L
I
I
L
A
A
R
P
G
M
G
K
T
A
F
M
L
S
I
I
Y
N
L
A
K
D
E
G
K
P
S
A
V
F
S
L
E
M
S
K
E
Q
L
V
M
R
L
L
S
M
M
S
E
V
P
L
F
K
I
R
S
G
S
I
S
N
E
D
L
K
K
L
E
A
S
A
I
E
L
A
K
Y
D
I
Y
L
D
D
T
P
A
L
T
T
T
D
L
R
I
R
A
R
K
L
R
K
E
K
--
E
V
E
F
V
A
V
D
Y
L
Q
L
L
R
P
P
V
R
-
K
-
S
P
R
Q
E
E
V
A
E
V
S
R
N
L
K
A
L
A
K
E
L
R
I
P
V
M
A
L
A
Q
L
S
--------
K
R
P
Q
L
A
D
L
R
E
S
G
Q
I
E
Q
D
A
D
L
I
L
F
L
H
R
P
E
Y
Y
T
-----P
E
E
Q
G
I
A
E
V
I
I
A
K
Q
R
Q
G
P
T
D
I
V
K
L
A
F
I
K
E
Y
T
K
F
A
N
L
------------
6
PsiBlast_PDB
73.98
39%
-7
- C4 -
-
4NMN
1
?
A:
[2-432]
-------------------------------
P
C
D
E
S
A
E
R
A
V
L
G
S
M
L
E
D
P
E
N
I
P
L
V
L
E
Y
L
-
K
E
E
D
F
C
I
D
E
H
K
L
L
F
R
V
L
T
N
L
W
S
E
Y
G
N
K
L
D
F
V
L
I
K
D
H
L
E
K
K
N
L
L
Q
---
I
D
-
W
L
E
E
L
Y
E
E
A
V
S
P
D
T
---
L
E
E
V
C
K
I
V
K
Q
R
S
A
Q
R
A
I
I
Q
L
G
I
E
L
I
H
K
G
K
E
N
K
D
--
F
H
T
L
I
E
E
A
Q
S
R
I
F
S
I
A
E
S
--
S
T
Q
F
-----
Y
H
V
K
D
V
A
E
E
V
I
E
L
I
Y
K
F
K
S
S
D
R
L
V
T
G
L
P
S
G
F
T
E
L
D
L
K
T
T
G
F
H
P
G
D
L
I
I
L
A
A
R
P
G
M
G
K
T
A
F
M
L
S
I
I
Y
N
L
A
K
D
E
G
K
P
S
A
V
F
S
L
E
M
S
K
E
Q
L
V
M
R
L
L
S
M
M
S
E
V
P
L
F
K
I
R
S
G
S
I
S
N
E
D
L
K
K
L
E
A
S
A
I
E
L
A
K
Y
D
I
Y
L
D
D
T
P
A
L
T
T
T
D
L
R
I
R
A
R
K
L
R
K
--
E
K
E
V
E
F
V
A
V
D
Y
L
Q
L
L
R
P
P
V
R
-
K
-
S
P
R
Q
E
E
V
A
E
V
S
R
N
L
K
A
L
A
K
E
L
R
I
P
V
M
A
L
A
Q
L
S
R
E
V
E
K
R
S
D
K
R
P
Q
L
A
D
L
R
E
S
G
Q
I
E
Q
D
A
D
L
I
L
F
L
H
R
P
E
Y
Y
T
K
K
PN---
E
Q
G
I
A
E
V
I
I
A
K
Q
R
Q
G
P
T
D
I
V
K
L
A
F
I
K
E
Y
T
K
F
A
N
L
------------
75
Fugue
73.54
42%
-4
- C4 -
-
2Q6T
-
?
A:
[5-440]
-----------------------------
I
P
P
H
S
L
E
A
E
Q
S
V
L
G
S
I
L
L
D
S
D
V
M
D
E
V
E
G
L
L
P
S
P
E
A
F
Y
A
E
A
H
R
K
I
Y
A
A
M
Q
A
L
R
S
Q
-
G
R
P
V
D
L
V
T
L
S
E
E
L
S
R
R
G
Q
L
E
E
V
G
G
T
A
Y
L
L
Q
L
S
--
E
A
T
P
T
A
-
A
Y
A
E
H
Y
A
R
I
V
A
E
K
W
T
L
R
R
L
I
Q
A
A
G
E
A
M
R
L
A
Y
E
E
A
G
S
-
L
D
E
I
L
D
T
A
G
K
K
I
L
E
V
A
L
T
K
T
D
T
E
A
R
P
---------------
M
R
E
L
V
H
E
T
F
E
H
I
E
A
V
R
T
G
F
K
E
L
D
Q
L
I
G
T
L
G
P
G
S
L
N
I
I
A
A
R
P
A
M
G
K
T
A
F
A
L
T
I
A
Q
N
A
A
L
K
E
G
V
G
V
G
I
Y
S
L
E
M
P
A
A
Q
L
T
L
R
M
M
C
S
E
A
R
I
D
M
N
R
V
R
L
G
Q
L
T
D
R
D
F
S
R
L
V
D
V
A
S
R
L
S
E
A
P
I
Y
I
D
D
T
P
D
L
T
L
M
E
V
R
A
R
A
R
R
L
V
S
Q
N
Q
--
V
G
L
I
I
I
D
Y
L
Q
L
M
S
-----
G
-
P
N
R
Q
Q
E
I
A
A
I
S
R
G
L
K
A
L
A
R
E
L
G
I
P
I
I
A
L
S
Q
L
S
R
A
V
E
A
R
P
N
K
R
P
M
L
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
L
V
M
F
I
Y
R
D
E
Y
Y
N
P
H
--
S
-
E
K
A
G
I
A
E
I
I
V
G
K
Q
R
N
G
P
T
G
T
V
E
L
Q
F
H
A
S
H
V
R
F
N
D
L
------------
54
HHSearch
73.43
41%
-6
- C4 -
-
2Q6T
-
?
A:
[5-440]
-----------------------------
I
P
P
H
S
L
E
A
E
Q
S
V
L
G
S
I
L
L
D
S
D
V
M
D
E
V
E
G
L
L
P
S
P
E
A
F
Y
A
E
A
H
R
K
I
Y
A
A
M
Q
A
L
R
S
Q
-
G
R
P
V
D
L
V
T
L
S
E
E
L
S
R
R
G
Q
L
E
E
V
G
G
T
A
Y
L
L
Q
L
S
--
E
A
T
P
T
A
-
A
Y
A
E
H
Y
A
R
I
V
A
E
K
W
T
L
R
R
L
I
Q
A
A
G
E
A
M
R
L
A
Y
E
E
A
-
G
S
L
D
E
I
L
D
T
A
G
K
K
I
L
E
V
A
L
T
K
----
T
D
T
E
A
-
R
P
M
R
E
L
V
H
E
T
F
E
H
I
E
A
----------
V
R
T
G
F
K
E
L
D
Q
L
I
G
T
L
G
P
G
S
L
N
I
I
A
A
R
P
A
M
G
K
T
A
F
A
L
T
I
A
Q
N
A
A
L
K
E
G
V
G
V
G
I
Y
S
L
E
M
P
A
A
Q
L
T
L
R
M
M
C
S
E
A
R
I
D
M
N
R
V
R
L
G
Q
L
T
D
R
D
F
S
R
L
V
D
V
A
S
R
L
S
E
A
P
I
Y
I
D
D
T
P
D
L
T
L
M
E
V
R
A
R
A
R
R
L
V
S
Q
N
--
Q
V
G
L
I
I
I
D
Y
L
Q
L
M
S
G
P
------
N
R
Q
Q
E
I
A
A
I
S
R
G
L
K
A
L
A
R
E
L
G
I
P
I
I
A
L
S
Q
L
S
R
A
V
E
A
R
P
N
K
R
P
M
L
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
L
V
M
F
I
Y
R
D
E
Y
Y
N
P
H
--
S
-
E
K
A
G
I
A
E
I
I
V
G
K
Q
R
N
G
P
T
G
T
V
E
L
Q
F
H
A
S
H
V
R
F
N
D
L
------------