@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VM17: (2017-11-05 )
MEARVIGLEKLGKHDVELVGGKNSSLGEMISHLSNAGVSVPGGFATTADAYREFLDQSGLNARIQAELAELNVDDVNALAETGAKIRQWIVETPLTPGLEQEIREAFAALSNGNPDIAVAVRSSATAEDLPDASFAGQQETFLNIRGIDNVLIAVKEVFASLFNDRAIAYRVHQGFEHSLVALSAGVQRMVRSETGAAGVMFTLDTESGFRDVVFITASYGLGEMVVQGAVNPDEFYLSKPLLNAGKHAVLRRNLGSKHQKMIYGEEGSAGKSVVVVDVEKQERQQFALNDHELQELAKQALIIEKHYGAPMDIEWAKDGDDGQIYIVQARPETVKSRQNVGTMERYLLKQKGTVLCEGRSIGQRIGSGKVRIVNSIKEMDKVQDGDVLVSDMTDPDWEPVMKRAAAIITNRGGRTCHAAIITRELGVPAIVGCGNATEVLTDGQEVTVSCAEGDTGFIYEGALDFEVQRNSIESMPKLSFKIMMNVGNPDRAFDFAQIPNEGIGLARLEFIINRMIGVHPKALLNIESLPRETRAAVMTRTAGYASPVEFYVEKLVEGIATLAAAFADKPVIVRMSDFKSNEYANLIGGKLYEPEEENPMLGFRGASRYISDNFRDCFELECRALKKVRDEMGLTNIQIMIPFVRTVSEAKRVIELLAQNGLKRGENGLKVIMMCELPTNALLAEQFLEHFDGFSIGSNDLTQLTLGLDRDSGIVSHLFDERDAAVKALLSMAIHACRKAGKYVGICGQGPSDHPDLAKWLMEQGIESVSLNPDSVLDTWFFLAEEKIKQI
Atome Classification :
(20 SA)
........-.10---.......-..20........30....-....40........50......-----.-----.-----60......-------..70.-------.---------------------------------------..---------------------------------------.---.---------..-80------------------.------.------..------------..-----------.-------.90---------..------------------------------------.--......100-----------------------.--------..---------..--------..---110---------------...--------------------.--------------------..-----------------------------------.120---------------........130..--....-.----140--------..-----..------------.-------.-----.150..-------------------------.....160.......170.......180.......190--..-----.---..----...200.....-------------------..210.......220.......230.......240.-......250.......260....--.--..270....-...280.......290.......300--.........---310.......320.......330-----...------------------.....340---------.---------.-----------.-------.--------------.------------.---.350-----------.---.......360---------------......----------.370.-.-..-...-380..-.....390.......400.......410.......420.......430....------------.-----.------------.------------440.......-----450--.....-------....460---------.--.------.....470------.-------.-------.-.....--------480---.........490.......500.......510-.........520........530-..-.....540.......550.......560.......570--.......580..--------------------.------------..------------..----------590-----------------.-------.-.------------------.....600.......610-.--.......620......----.630----.---.-.-.-..-.----640.......650.---.----.....660..-----.-----.-..-----.670--.........680.......690.......700.......710-----------..------------.--..--.--------.-------720.------.-------------.....730.......--740----.--..------.--.....750.......760.......770.......780.......790
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEA
R
V
I
G
L
-
E
K
----LGKH
D
V
E
-
L
VGGKNS
S
L
G
E
M
I
S
H
L
SN-AGVSVPGGFA
T
T
A
D
A
Y
R
E
F
L
D
Q-----S-----G-----LN
A
R
I
Q
A
E
-------
L
A
EL
N
-------
V
---------------------------------------
D
D
---------------------------------------
V
---
N
---------
A
L
-
A
E
------------------
T
------
G
------
A
K
------------
I
R
-----------
Q
-------
W
I
----------
V
E------------------------------------T--PLTP
G
L
E
Q
E
-----------------------
I
--------
R
E
---------
A
F
--------
A
A
---LSN---------------GNP--------------------
D
--------------------
I
A
-----------------------------------
V
A
V----------------RSSATAEDLPDAS--FAGQ-Q----
E
T
F
--------
L
N
-----IR------------G-------I-----
D
N
V
L
I
A
-------------------------
V
K
E
V
F
A
S
L
FNDR
A
I
A
Y
R
VHQGF
E
H
S
L
V
A
L
S
A
G
V
Q
R
M
V
---
R
S-----E---TG----A
A
G
V
M
F
T
LDTE-------------------SGF
R
D
V
V
F
I
T
ASYG
L
G
E
M
V
V
QGAV
N
P
D
E
F
Y
LSK
P
L
L
-
N
A
G
K
H
A
V
L
R
R
NLGS
K
H
Q
K
M
I
YGE--E--GSAG
K
S
V
V
V
-
V
DV
E
K
Q
E
R
Q
Q
FAL
N
D
H
E
L
Q
E
L
A
K
Q
----
A
L
I
I
EKHYG---APM
D
I
E
WAKDGDD
G
Q
I
Y
I
V
QAR------
P
E
T
------------------
V
K
S
RQNV
G
---------
T
---------
M
-----------
E
-------
R
--------------
Y
------------
L
---
L
KQ------------K---
G
T
V
L
CEG
R
S
I
---------------
G
Q
R
IGS----------G
K
V
R
I
-
V
-
N
S
-
I
K
E
-
M
D
KVQ-DG
D
V
L
V
SDMTDP
D
W
E
P
V
M
K
R
A
A
A
I
ITNRGG
R
T
C
H
A
A
I
I
TRELGV
P
A
I
VGCG
N
------------
A
-----
T
------------
E
------------VLTDG
Q
E
V
T
V
-----
S
----CAEGD-------T
G
F
I
Y
EG---------
A
--
L
------
D
F
E
V
QR
N
-------
S
-------
I
-------E-SMPK
L
--------
S
-----
F
K
I
M
M
NVGNPDRAF
D
F
A
QIPNEGI
G
L
A
R
L
E
---
F
I
I
N
R
M
IGV
H
P
-
K
A
L
L
N
I
E
SL
P
R
-
E
T
-
R
A
A
V
M
TRTAGY
A
S
P
V
E
F
Y
V
E
K
L
V
E
G
I
A
T
L
A
A
A
FADK
P
V
--
I
V
R
MSDFKS
N
E
Y
--------------------
A
------------
N
L------------IG----------GK------------------L-------Y-E------------------PEEENP
M
L
GFR
G
A
S
R
Y
I
--
S
--
D
N
F
R
D
C
F
E
L
E
C
R
A
L
K
K
----
V
R
D
E
----M---G-L-
T
-
N
I
-
Q
----
I
M
I
P
F
V
R
T
V
S
E
A
K
R
---
V
----
I
E
L
L
A
Q
NGLK-----R-----G-EN-----G
L
----
K
V
I
M
M
CELPT
N
A
L
L
A
E
Q
F
L
E
H
FDGFSIGSND
L
T
Q
L
T
LGLDRD-----------S
G
------------
I
--
V
S
--
H
--------
L
-------FDE
R
------
D
-------------
A
A
V
K
A
L
L
S
M
A
I
H
A
C
R
--K------A--G
K
------
Y
--
V
G
I
CGQGPSD
H
P
D
L
A
K
W
L
M
EQGIESVSLN
P
D
S
V
L
D
T
W
F
F
L
A
E
E
K
I
KQI
23
HHSearch
66.08
27%
29
- C2 -
-
1VBG
-
PPDK1_MAIZE
A:
[3-874]
-
K
K
R
V
F
H
F
-
G
K
GKSE
G
N
K
T
M
K
E
-
L
L
G
G
K
G
A
N
L
A
E
M
A
----
S
-
I
G
L
S
V
P
P
G
F
T
V
S
T
E
A
C
Q
Q
Y
Q
D
A
G
CALP
A
-----
G
-----
L
W
A
E
I
V
D
G
-------
L
Q
W
V
E
-------
E
Y
M
GATL---------------------------------
G
D
---------------------------------------
P
QR
P
L
---------
L
L
-
S
V
------------------
R
------
S
G
A
AVSM
P
G
------------
M
M
-----------
D
-------
T
V
----------
L
N
------------------------------------
L
--
G
L
N
D
E
V
A
A
G
-----------------------
L
--------
A
A
KSG
E
R
F
A
Y
D
S
F
--------
R
R
---
F
L
D
---------------
M
F
G
--------------------
N
VVMDIP
R
S
L
F
E
E
K
L
E
H
M
K
E
S
K
G
-----------------------------------
L
K
N
----------------
D
T
D
L
T
A
S
D
L
--
K
E
--
L
V
G
Q
-
Y
----
K
E
V
Y
-------
L
S
-----
A
K
------------
G
EPFPSD
P
K
-----
K
Q
L
E
L
A
-------------------------
V
L
A
V
F
N
S
W
E
S
P
R
A
K
K
Y
R
S
I
N
Q
I
T
G
-
L
R
G
T
A
V
N
V
Q
C
M
V
---
F
G
-----
N
MGN
T
S
----
G
T
G
V
L
F
T
R
N
P
N
-------------------
T
G
E
K
K
L
Y
G
E
F
L
V
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
E
D
L
D
A
M
K
-----------------------------------------------------
N
L
M
P
Q
A
Y
D
E
L
V
E
N
----
C
N
I
L
E
S
H
Y
K
---
E
M
Q
D
I
E
F
T
V
Q
E
--
N
R
L
W
M
L
Q
C
R
------
T
G
K
------------------
R
T
G
K
S
A
V
K
---------
I
A
V
D
M
V
N
E
GL
V
E
P
R
S
A
I
-----
K
M
------
V
E
P
G
H
L
D
Q
L
L
H
PQFE
N
------------
P
---
S
A
Y
------------
K
---
D
Q
V
I
A
T
G
L
P
A
---------------
S
P
G
A
A
V
----------
G
Q
V
V
F
-
T
-
A
E
-
D
A
E
A
W
H
S
Q
G
-
K
A
A
I
L
V
R
A
E
T
S
P
E
D
V
G
G
M
H
A
A
V
G
I
L
T
E
R
G
G
M
T
S
H
A
A
V
V
A
R
G
W
G
K
C
C
V
S
G
C
S
G
------------
I
-----
R
VNDAEK
L
V
T
I
GG
H
------------
V
L
R
E
G
E
W
L
S
L
------------
N
G
S
-------
T
G
E
V
I
L
G
---------
K
--
Q
------
P
L
S
P
P
A
L
-------
S
G
D
L
G
T
F
M
A
-------
W
-
V
D
D
V
R
--------
K
-----
L
K
V
L
A
N
A
D
T
P
D
D
A
L
T
A
R
N
N
G
A
Q
G
I
G
L
C
R
T
E
---
H
M
F
F
A
S
-
D
E
R
I
-
K
A
V
R
Q
M
I
M
A
P
T
-
L
E
L
R
Q
Q
A
----------
L
D
R
L
L
P
Y
Q
R
S
D
F
E
G
I
F
R
A
M
D
G
L
P
V
--
T
I
R
L
L
D
P
P
L
H
E
F
--------------------
L
------------
P
E
G
N
I
E
D
I
V
S
E
L
C
A
E
T
----------
G
A
------------------
N
Q
E
D
A
L
A
R
I
E
K
------------------
L
S
E
V
N
P
M
L
G
F
R
G
C
R
L
G
I
--
S
--
Y
--
P
E
L
T
E
M
Q
A
R
A
I
F
E
----
A
A
I
A
M
T
N
-
Q
---
G
V
Q
-
V
-
F
P
-
E
----
I
M
V
P
L
V
G
T
P
Q
E
L
G
H
---
Q
----
V
T
L
I
R
Q
V
A
E
K
V
F
A
N
-
V
G----
K
-
T
I
-----
G
Y
----
K
V
G
T
M
I
E
I
P
R
A
A
L
V
A
D
E
I
A
E
Q
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
Y
S
R
D
-----------
D
V
------------
G
K-
F
I
--
P
V
Y
L
A
Q
GIL
Q
-------
H
D
P
F
------
E
-------------
V
L
D
Q
R
G
V
G
E
L
V
K
F
A
T
--
E
R
G
R
K
A
R
P
--
N
L
------
K
--
V
G
I
C
G
E
H
G
G
E
-
P
S
S
V
A
F
F
A
K
A
G
L
D
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
V
-----
25
HHSearch
65.19
26%
20
* C2 *
-
5JVL
2
PPDK_FLATR
D:
[1-872]
-
K
K
R
V
F
T
F
-
G
K
GRSE
G
N
R
D
M
K
S
-
L
L
G
G
K
G
A
N
L
A
E
M
S
----
S
-
I
G
L
S
V
P
P
G
L
T
I
S
T
E
A
C
E
E
Y
Q
Q
N
-----
G
KSLPP
G
-----
L
W
D
E
I
S
E
G
-------
L
D
Y
V
Q
-------
K
---------------------------------------
E
M
---------------------------------------
S
---
A
SLGDPSKPL
L
L
-
S
V
------------------
R
------
S
GAAISM
P
G
------------
M
M
-----------
D
-------
T
V
----------
L
N
------------------------------------
L
--
G
L
N
D
E
V
V
A
G
-----------------------
L
--------
A
G
KSGARF---
A
Y
--------
D
S
YRR
F
L
D
---------------
M
F
G
--------------------
N
VVMGIPHSLFDEKLEQMKAE
K
G
-----------------------------------
I
H
L
----------------
D
T
D
L
T
A
A
D
L
K
D
L
V
EK
Y
K
N
V
-
Y
VEAK
G
E
K
--------
F
P
-----
T
D
------------
P
-------
K
-----
K
Q
L
E
L
A
-------------------------
V
N
A
V
F
D
S
W
D
S
P
R
A
N
K
Y
R
S
I
N
Q
I
T
G
L
-
K
G
T
A
V
N
I
Q
S
M
V
---
F
G
-----
N
MGN
T
S
----
G
T
G
V
L
F
T
R
N
P
S
-------------------
T
G
E
K
K
L
Y
G
E
F
L
I
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
E
D
L
G
T
M
-----------------------------------------------------
E
T
C
M
P
E
A
Y
K
E
L
V
E
N
----
C
E
I
L
E
R
H
Y
K
---
D
M
M
D
I
E
F
T
V
Q
E
--
N
R
L
W
M
L
Q
C
R
------
T
G
K
------------------
R
T
G
K
G
A
V
R
IAVD-----
M
---------
V
NEGLIDTRTAI
K
R------
V
ETQHLDQLLHPQFE
D
------------
P
---
S
A
Y
------------
K
---
S
H
V
V
A
T
G
L
P
A
---------------
S
P
G
A
A
V
----------
G
Q
V
C
F
-
S
-
A
E
-
D
A
E
T
W
H
A
Q
G
-
K
S
A
I
L
V
R
T
E
T
S
P
E
D
V
G
G
M
H
A
A
A
G
I
L
T
A
R
G
G
M
T
S
H
A
A
V
V
A
R
G
W
G
K
C
C
V
S
G
C
A
D
------------
I
-----
R
VNDDMKIFTIGD
R
------------
V
I
K
E
G
D
W
L
S
L
------------
N
G
T
-------
T
G
E
V
I
L
G
---------
K
--
Q
------
L
L
A
P
P
A
M
-------
S
NDLEIFM
S
-------
W
-
A
D
Q
A
R
--------
R
-----
L
K
V
M
A
N
A
D
T
P
N
D
A
L
T
A
R
N
N
G
A
Q
G
I
G
L
C
R
T
E
---
H
M
F
F
A
S
-
D
E
R
I
-
K
A
V
R
K
M
I
M
A
V
T
-
P
E
-
Q
---------
R
K
V
A
L
D
L
L
L
P
Y
Q
R
S
D
F
E
G
I
F
R
A
M
D
G
L
P
V
--
T
I
R
L
L
D
P
P
L
H
E
F
--------------------
L
PEGDLEHIVNEL
A
V
------------
D
T
----------
G
M
------------------
S
-------
A
-
D
EIYSKIEN----------
L
S
E
V
N
P
M
L
G
F
R
G
C
R
L
G
I
--
S
--
Y
--
P
E
L
T
E
M
Q
V
R
A
I
F
Q
----
A
A
V
S
----
M
TNQ
G
V
T
-
V
-
I
P
-
E
----
I
M
V
P
L
V
G
T
P
Q
E
L
R
H
---
Q
----
I
S
V
I
R
G
V
A
A
N
-----
V
FAEM-
G
V
T
L
-----
E
Y
----
K
V
G
T
M
I
E
I
P
R
A
A
L
I
A
E
E
I
G
K
E
A
D
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
Y
S
R
D
-----------
D
V
------------
G
--
K
F
LQ
I
--------
Y
LAQGILQ
H
D
P
F
EVID--
Q
-------------
K
G
V
G
Q
L
I
K
M
A
T
E
K
G
R
--
A
------
A
NP
S
L
------
K
--
V
G
I
C
G
E
H
G
G
E
-
P
S
S
V
A
F
F
D
G
V
G
L
D
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
V
-----
17
PsiBlast_PDB
64.64
24%
30
- C2 -
-
1VBG
-
PPDK1_MAIZE
A:
[22-861]
---------------------
E
-
L
L
G
G
K
G
A
N
L
A
E
M
A
S
-----
I
G
L
S
V
P
P
G
F
T
V
S
T
E
A
C
Q
Q
Y
Q
D
A
G
----
C
-----
A
-----
L
P
A
G
L
W
A
E
-------
I
-----------
V
---------------------------------------
D
G
---------------------------------------
L
---
Q
---------
W
V
-
E
E
Y
M
GATLGDPQR
P
L
L
L
S
V
R
S
------
G
------
A
A
------------
V
S
-----------
M
P------
G
M
----------
M
D
------------------------------------
T
--
V
L
N
L
G
L
N
D
E
-----------------------
V
--------
A
A
---------
G
L
--------
A
A
---
K
S
G
E
R
F
A
Y
D
S
F
R
R
F
L
D
M
F
G
N
V
VM------------------
D
--------------------
I
P
-----------------------------------
R
S
L
F
E
E
K
L
E
H
M
K
E
S
K
GLKN
D
T
D
L
T
A
S
D
L
K
E
----
L
V
G
Q
Y
K
----
E
V
Y
--------
L
S
-----
A
K
------------
G
EPFPSD
P
K
-----
K
Q
L
E
L
A
-------------------------
V
L
A
V
F
N
S
W
E
S
P
R
A
K
K
Y
R
S
I
N
Q
I
T
-
G
L
R
G
T
A
V
N
V
Q
C
M
V
F
GN
M
G
-----
N
---
T
S
----
G
T
G
V
L
F
T
R
N
P
N
-------------------
T
G
E
K
K
L
Y
G
E
F
L
V
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
E
D
L
D
A
M
K
N
L
M
P
Q
A
Y
D
E
L
V
E
N
C
N
I
L
E
S
H
Y
K
E
M
Q
D
----------------
I
E
F
T
V
Q
E
N
R
L
W
M
L
Q
C
R
T
G
K
R
T
G
K
S
----
A
V
K
I
A
-----------
V
D
M
V
N
E
G
--------
L
V
E
------
P
R
S
------------------
A
I
K
M
V
E
P
G
---------
H
---------
L
-----------
D
-------
Q
--------------
L
------------
L
---
H
P
Q
FENPSAY-----
K
---
D
Q
V
I
A
T
G
L
P
A
---------------
S
P
G
A
A
V
----------
G
Q
V
V
F
-
T
-
A
E
-
D
A
E
-
A
W
H
S
Q
G
K
A
A
I
L
V
R
A
E
T
S
P
E
D
V
G
G
M
H
A
A
V
G
I
L
T
E
R
G
G
M
T
S
H
A
A
V
V
A
R
G
W
G
K
C
C
V
S
G
C
S
G
IRVNDAEK
L
V
T
I
G
-----
G
------------
H
------------
V
L
R
E
G
E
W
L
S
L
-----
N
-------
G
S
-------
T
G
E
V
I
L
G
KQPLSPP--
A
--
L
SG----
D
L
G
T
F
M
A
-------
W
-------
V
-------
D
-
D
V
R
K
L
---------------
K
V
L
A
N
A
D
T
P
D
D
A
L
T
A
R
N
N
G
A
Q
G
I
G
L
C
R
T
E
H
M
F
F
A
S
D
E
R
I
-----
K
A
V
R
Q
M
I
M
A
P
T
L
E
L
-
R
Q
Q
A
L
D
R
L
L
P
Y
Q
R
S
D
F
E
G
I
F
R
A
M
D
G
L
----------
P
V
--
T
I
R
L
L
D
P
P
L
H
E
F
L
P
E
G
N
I
E
D
I
V
----------
S
------------
E
L
------------
C
A
E
TGAN
Q
E
D
A
L
A
R
------------------
I
-------
E
-
K
------------------
L
S
E
V
N
P
M
L
G
F
R
G
C
R
L
G
I
--
S
----
Y
P
E
L
T
E
M
Q
A
R
A
I
F
E
----
A
A
I
A
----
M
---
T
-
N
-
Q
-
G
V
-
Q
VF
P
E
I
M
V
P
L
V
G
T
P
Q
E
L
G
H
---
Q
----
V
T
L
I
R
Q
V
A
E
K
-----
V
-----
F
-
A
N
V
G
K
T
I
G
Y
----
K
V
G
T
M
I
E
I
P
R
A
A
L
V
A
D
E
I
A
E
Q
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
Y
S
R
D
DVGKF
I
P
V
Y
L
A
Q
G
------------
I
--
L
Q
--
H
DPFE----
V
-------
L
D
Q
R
---------------------
G
V
G
E
L
V
K
F
A
T
E
R
G
R
--
K
------
A
RP
N
L
------
K
--
V
G
I
C
G
E
H
-
G
G
E
P
S
S
V
A
F
F
A
K
A
G
L
D
Y
V
S
C
S
P
------------------
14
PsiBlast_PDB
64.53
24%
33
- C2 -
-
1DIK
-
PPDK_CLOSY
A:
[18-856]
-----------------------
L
L
G
G
K
G
C
N
L
A
E
M
----
T
I
-
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
-------------
K
Q
I
T
Q
E
-------
I
Q
D
Q
I
-------
F
---------------------------------------
E
A
---------------------------------------
I
---
T
---------
W
L
-
E
E
------------------
L
------
N
------
G
K
KFGDTE
D
P
L
L
V
S
V
R
-----------
S
A
A
R
A
S
M
P
G
M
----------
M
D
------------------------------------
T
--
I
L
N
L
G
L
N
D
V
-----------------------
A
--------
V
E
---------
G
F
--------
A
K
----
K
T
---------------
G
N
P
--------------------
R
--------------------
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
VVMEVP
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
----------------
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
-
Y
----
K
E
A
--------
M
N
-----
G
E
------------
E
-------
F
PQE
P
K
D
Q
L
M
G
A
-------------------------
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
-
G
T
A
V
N
V
Q
T
M
V
FGN
K
G
-----
E
---
T
S
----
G
T
G
V
A
F
T
R
N
P
S
-------------------
T
G
---------------------------------------------------
E
K
G
I
Y
G
E
--
Y
L
I
N
A
Q
G
E
D
V
V
A
-
G
V
R
T
P
Q
P
I
T
Q
L
---
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
---
D
M
Q
D
M
E
F
T
I
E
--
E
G
K
L
Y
F
L
Q
T
R
NGKRT
A
P
A
A
------------------
L
Q
I
A
C
D
L
----------
V
---------
D
-----------
E
-------
G
--------------
M
------------
I
---
T
E
E
------------
E
---
A
V
V
R
I
E
A
K
S
L
DQLLHPTFN
P
A
A
L
K
A
G
E
V
I
G
S
ALPA
S
P
G
A
A
A
G
K
V
Y
F
-
T
A
D
E
-
A
K
A
-
A
H
E
K
G
-
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
--------------------------------
E
------------
I
K
I
N
E
E
A
K
T
F
E
L
GG
H
T
----
F
A
E
G
D
YISLDGS
T
G
K
I
-----------------------
I
E
T
Q
E
A
-------
S
-------
V
-------
S
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
-----
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
D
R
I
M
K
I
R
K
-
M
I
L
----
S
D
S
V
-
E
A
-
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
-
R
P
M
T
V
R
Y
L
D
P
P
L
HE
F
V
P
H
T
E
E
E
Q
A
E
L
--------------------
A
------------
K
N
------------
M
G
LT
L
A
E
V
K
---
A
K
------------------
V
-------
D
-
E
------------------
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
--
T
----
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
----
T
---
G
-
I
-
D
-
I
V
P
E
----
I
M
I
P
L
V
G
E
K
K
E
L
K
F
---
V
K
D
V
V
V
E
V
A
E
Q
V
K
K
E
-----
K
-----
G
-
S
D
M
----
Q
Y
----
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
D
-----------
D
A
GKF
L
D
S
Y
Y
K
A
KI
Y
--
E
S
--
D
--------
P
-------
F
A
R
L
------
D
Q------------
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
R
------
P
--
G
L
------
K
--
C
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
------------------
18
PsiBlast_PDB
63.56
24%
26
- C2 -
-
1VBH
1
PPDK1_MAIZE
A:
[22-861]
---------------------
E
-
L
L
G
G
K
G
A
N
L
A
E
M
A
S
-----
I
G
L
S
V
P
P
G
F
T
V
S
T
E
A
C
Q
Q
Y
Q
D
A
G----
C
-----
A
-----
L
P
A
G
L
W
A
E
-------
I
-----------
V
---------------------------------------
D
G
---------------------------------------
L
---
Q
---------
W
V
-
E
E
Y
M
GATLGDPQR
P
L
L
L
S
V
R
S
------
G
------
A
A
------------
V
S
-----------
M
P------
G
M
----------
M
D
------------------------------------
T
--
V
L
N
L
G
L
N
D
E
-----------------------
V
--------
A
A
---------
G
L
--------
A
A
---
K
S
G
E
R
F
A
Y
D
S
F
R
R
F
L
D
M
F
G
N
V
VM------------------
D
--------------------
I
P
-----------------------------------
R
S
L
F
E
E
K
L
E
H
M
K
E
S
K
GLKN
D
T
D
L
T
A
S
D
L
K
E
----
L
V
G
Q
Y
K
----
E
V
Y
--------
L
S
-----
A
K
------------
G
EPFPSD
P
K
-----
K
Q
L
E
L
A
-------------------------
V
L
A
V
F
N
S
W
E
S
P
R
A
K
K
Y
R
S
I
N
Q
I
T
-
G
L
R
G
T
A
V
N
V
Q
C
M
V
F
GN
M
G
-----
N
---
T
S
----
G
T
G
V
L
F
T
R
N
P
N
-------------------
T
G
E
K
K
L
Y
G
E
F
L
V
N
A
---------
R
T
P
E
D
L
D
A
M
K
N
L
M
P
Q
A
Y
D
E
L
V
E
N
C
N
I
L
E
S
H
Y
K
E
M
Q
D
----------------
I
E
F
T
V
Q
E
N
R
L
W
M
L
Q
C
R
T
G
K
R
T
G
K
S
----
A
V
K
I
A
-----------
V
D
M
V
N
E
G
--------
L
V
E
------
P
R
S
------------------
A
I
K
M
V
E
P
G
---------
H
---------
L
-----------
D
-------
Q
--------------
L
------------
L
---
H
P
Q
FENPSAY-----
K
---
D
Q
V
I
A
T
G
L
P
A
---------------
S
P
G
A
A
V
----------
G
Q
V
V
F
-
T
-
A
E
-
D
A
E
-
A
W
H
S
Q
G
K
A
A
I
L
V
R
A
E
T
S
P
E
D
V
G
G
M
H
A
A
V
G
I
L
T
E
---
M
T
S
H
A
A
V
V
A
R
G
W
G
K
C
C
V
S
G
C
S
G
I
R
V
N
DAEK
L
V
T
I
G
-----
G
------------
H
------------
V
L
R
E
G
E
W
L
S
L
-----
N
-------
G
S
-------
T
G
E
V
I
L
G
K
Q
P
L
SPP--
A
--
L
SG----
D
L
G
T
F
M
A
-------
W
-------
V
-------
D
-
D
V
R
K
L
---------------
K
V
L
A
N
A
D
T
P
D
D
A
L
T
A
R
N
N
G
A
Q
G
I
G
L
C
R
T
E
H
M
F
F
A
S
D
E
R
I
-----
K
A
V
R
Q
M
I
M
A
P
T
L
E
L
-
R
Q
Q
A
L
D
R
L
L
P
Y
Q
R
S
D
F
E
G
I
F
R
A
M
D
G
L
----------
P
V
--
T
I
R
L
L
D
P
P
L
H
E
F
L
P
E
G
N
I
E
D
I
V
----------
S
------------
E
L
------------
C
A
E
TGAN
Q
E
D
A
L
A
R
------------------
I
-------
E
-
K
------------------
L
S
E
V
N
P
M
L
G
F
R
G
C
R
L
G
I
--
S
----
Y
P
E
L
T
E
M
Q
A
R
A
I
F
E
----
A
A
I
A
----
M
---
T
-
N
-
Q
-
G
V
-
Q
VF
P
E
I
M
V
P
L
V
G
T
P
Q
E
L
G
H
---
Q
----
V
T
L
I
R
Q
V
A
E
K
-----
V
-----
F
-
A
N
V
G
K
T
I
G
Y
----
K
V
G
T
M
I
E
I
P
R
A
A
L
V
A
D
E
I
A
E
Q
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
Y
S
R
D
DVGKF
I
P
V
Y
L
A
Q
G
------------
I
--
L
Q
--
H
DPFE----
V
-------
L
D
Q
R
---------------------
G
V
G
E
L
V
K
F
A
T
E
R
G
R
--
K
------
A
RP
N
L
------
K
--
V
G
I
C
G
E
H
-
G
G
E
P
S
S
V
A
F
F
A
K
A
G
L
D
Y
V
S
C
S
P
------------------
22
HHSearch
62.86
25%
18
- C2 -
-
1KBL
-
PPDK_CLOSY
A:
[1-871]
-
A
K
W
V
Y
K
F
-
E
E
----
G
N
A
S
M
R
N
-
L
L
G
G
K
G
C
N
L
A
E
M
T
----
I
-
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
-----
K
Q----
I
T
Q
E
I
Q
D
Q
I
F
E
A
---
I
T
W
L
E
-------
E
---------------------------------------
L
N
---------------------------------------
G
---
K
---------
K
F
-
G
D
T
E
D
P
--------------
L
------
L
------
V
S
------------
V
R
S
G
A
R
A
S
M
P
GM
M
D
-------
T
I
----------
L
N
LGLN
D
V
A
V
E
G
F
A
K
K
T
GN
P
R
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
VV
M
--
E
V
P
K
S
H
F
E
K
-----------------------
I
--------
I
D
---------
A
M
--------
K
E
--------------------------------------------
E
--------------------
K
G
-----------------------------------
V
H
F
----------------
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
-
Y
----
K
E
A
--------
M
N
GEEFP
Q
E
------------
P
-------
K
-----
D
Q
L
M
G
A
-------------------------
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
-
D
W
G
T
A
V
N
V
Q
T
M
V
---
F
G
NKGET
S
---------
G
T
G
V
A
F
T
R
N
P
S
-------------------
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
Q
L
E
N
D
-----------------------------------------------------
M
P
D
C
Y
K
Q
F
M
D
L
----
A
M
K
L
E
K
H
F
R
---
D
M
Q
D
M
E
F
T
I
E
E
--
G
K
L
Y
F
L
Q
T
R
------
N
G
K
------------------
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
---------
I
-----------
T
E
E
E
A
V
V
R
I
EA------------
K
SLDQLLHPTFN
P
A
---
A
L
K
------------
A
---
G
E
V
I
G
S
A
L
P
A
---------------
S
P
G
A
A
A
----------
G
K
V
Y
F
-
T
-
A
D
-
E
A
K
A
A
H
E
K
G
-
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
------------
I
-----
K
INEEAK
T
F
E
L
GG
H
------------
T
F
A
E
G
D
Y
I
S
L
------------
D
G
S
-------
T
G
K
I
Y
K
G
---------
D
--
I
------
E
T
Q
E
A
S
V
-------
S
-------
G
S
F
E
R
I
M
V
W
-
A
D
K
F
R
--------
T
-----
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
---
H
M
F
F
E
A
D
R
I
M
K
I
R
K
M
I
L
S
D
S
V
E
A
-
R
---
E
E
----------
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
--
T
V
R
Y
L
D
P
P
L
H
E
F
--------------------
V
------------
P
H
------------
T
E
----------
E
E
Q
A
E
L
A
K
N
M
GLT
L
A
E
V
K
A
K
V
-------
D
-
E
------------------
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
--
T
--
Y
--
P
E
I
A
K
M
Q
T
R
A
V
M
E
----
A
A
I
E
V
K
E
E
T
---
G
I
D
-
I
-
V
P
-
E
----
I
M
I
P
L
V
G
E
K
K
E
L
K
F
---
V
----
K
D
V
V
V
E
V
A
E
Q
-----
V
K
K
E
K
G
S
-
D
M
-----
Q
Y
----
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
D
-----------
D
A
------------
G
KF
L
D
--
S
--------
Y
Y
K
A
KIYE
S
D
P
F
ARLD--
Q
-------------
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
--
Q
T
R----
P
--
G
L
------
K
--
C
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
--
10
PsiBlast_PDB
62.18
24%
40
- C2 -
-
1KC7
1
PPDK_CLOSY
A:
[17-855]
-----------------------
L
L
G
G
K
G
C
N
L
A
E
M
----
T
I
-
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
-----
K
Q----
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
GKKFGDT
E
---------------------------------------
D
P
---------------------------------------
L
---
L
---------
V
S
-
V
R
------------------
S
------
G
------
A
R
------------
A
S
-----------
M
P
------
G
M
----------
M
D
------------------------------------
T
--
I
L
N
L
G
L
N
D
V
-----------------------
A
--------
V
E
---------
G
F
--------
A
K
----
K
T
---------------
G
N
P
--------------------
R
--------------------
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
VMEVPK
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
----------------
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
-
Y
----
K
E
A
--------
M
N
-----
G
E
------------
E
-------
F
PQE
P
K
D
Q
L
M
G
A
-------------------------
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
-
G
T
A
V
N
V
Q
T
M
V
F
GN
K
G
-----
E
---
T
S
----
G
T
G
V
A
F
T
R
N
P
S
-------------------
T
G
---------------------------------------------------
E
K
G
I
Y
G
E
--
Y
LI
N
A
Q
G
E
D
V
V
A
-
G
V
R
T
P
Q
P
I
T
Q
L
---
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
---
D
M
Q
D
M
E
F
T
I
E
--
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
------------------
L
Q
I
A
C
D
L
----------
V
---------
D
-----------
E
-------
G
--------------
M
------------
I
---
T
E
E
------------
E
---
A
V
V
R
I
E
A
K
S
L
DQLLHPTFN
P
A
A
L
K
A
G
E
V
I
G
S
ALPA
S
P
G
A
A
A
G
K
V
Y
F
-
T
A
D
E
-
A
K
A
-
A
H
E
K
G
-
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
--------------------------------
E
------------
I
K
I
N
E
E
A
K
T
F
E
L
GG
H
T
----
F
A
E
G
D
Y
I
S
L
D
GS
T
G
K
I
Y
K
G
-------------------
D
I
E
T
Q
E
A
-------
S
-------
V
-------
S
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
-----
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
D
R
I
M
K
I
R
K
-
M
I
L
----
S
D
S
V
-
E
A
-
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
-
R
P
M
T
V
R
Y
L
D
P
P
L
HE
F
V
P
H
T
E
E
E
Q
A
E
L
--------------------
A
------------
K
N
------------
M
G
LT
L
A
E
V
K
---
A
K
------------------
V
-------
D
-
E
------------------
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
--
T
----
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
----
T
---
G
-
I
-
D
-
I
V
P
E
----
I
M
I
P
L
V
G
E
K
K
E
L
K
F
---
V
K
D
V
V
V
E
V
A
E
Q
V
K
K
E
-----
K
-----
G
-
S
D
M
----
Q
Y
----
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
D
-----------
D
A
GKF
L
D
S
Y
Y
K
A
KI
Y
--
E
S
--
D
--------
P
-------
F
A
R
L
------
D
Q------------
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
R
------
P
--
G
L
------
K
--
C
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
------------------
9
PsiBlast_PDB
62.11
24%
42
- C2 -
-
1KBL
-
PPDK_CLOSY
A:
[17-855]
-----------------------
L
L
G
G
K
G
C
N
L
A
E
M
----
T
I
-
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
-----
K
Q----
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
GKKFGDT
E
---------------------------------------
D
P
---------------------------------------
L
---
L
---------
V
S
-
V
R
------------------
S
------
G
------
A
R
------------
A
S
-----------
M
P
------
G
M
----------
M
D
------------------------------------
T
--
I
L
N
L
G
L
N
D
V
-----------------------
A
--------
V
E
---------
G
F
--------
A
K
----
K
T
---------------
G
N
P
--------------------
R
--------------------
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
VVMEVPK
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
----------------
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
-
Y
----
K
E
A
--------
M
N
-----
G
E
------------
E
-------
F
PQE
P
K
D
Q
L
M
G
A
-------------------------
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
-
G
T
A
V
N
V
Q
T
M
V
F
GN
K
G
-----
E
---
T
S
----
G
T
G
V
A
F
T
R
N
P
S
-------------------
T
G
---------------------------------------------------
E
K
G
I
Y
G
E
--
Y
LI
N
A
Q
G
E
D
V
V
A
-
G
V
R
T
P
Q
P
I
T
Q
L
---
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
---
D
M
Q
D
M
E
F
T
I
E
--
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
------------------
L
Q
I
A
C
D
L
----------
V
---------
D
-----------
E
-------
G
--------------
M
------------
I
---
T
E
E
------------
E
---
A
V
V
R
I
E
A
K
S
L
DQLLHPTFN
P
A
A
L
K
A
G
E
V
I
G
S
ALPA
S
P
G
A
A
A
G
K
V
Y
F
-
T
A
D
E
-
A
K
A
-
A
H
E
K
G
-
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
--------------------------------
E
------------
I
K
I
N
E
E
A
K
T
F
E
L
GG
H
T
----
F
A
E
G
D
Y
I
S
L
DGS
T
G
K
I
Y
K
G
-------------------
D
I
E
T
Q
E
A
-------
S
-------
V
-------
S
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
-----
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
D
R
I
M
K
I
R
K
-
M
I
L
----
S
D
S
V
-
E
A
-
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
-
R
P
M
T
V
R
Y
L
D
P
P
L
HE
F
V
P
H
T
E
E
E
Q
A
E
L
--------------------
A
------------
K
N
------------
M
G
LT
L
A
E
V
K
---
A
K
------------------
V
-------
D
-
E
------------------
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
--
T
----
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
----
T
---
G
-
I
-
D
-
I
V
P
E
----
I
M
I
P
L
V
G
E
K
K
E
L
K
F
---
V
K
D
V
V
V
E
V
A
E
Q
V
K
K
E
-----
K
-----
G
-
S
D
M
----
Q
Y
----
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
D
-----------
D
A
GKF
L
D
S
Y
Y
K
A
KI
Y
--
E
S
--
D
--------
P
-------
F
A
R
L
------
D
Q------------
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
R
------
P
--
G
L
------
K
--
C
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
------------------
20
PsiBlast_PDB
62.10
23%
19
- C2 -
-
5JVL
2
PPDK_FLATR
A:
[14-859]
----------------
G
N
R
D
M
K
S
L
L
G
G
K
G
A
N
L
A
E
M
----
S
S
-
I
G
L
S
V
P
P
G
L
T
I
S
T
E
A
C
E
E
Y
-
Q
Q
-----
N
-----
G
-----
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
G
L
W
D
E
-----------------------
I
--------
S
E
---------
G
L
D
Y
V
Q
K
E
M
S
A
S
---
L
G
D
---------------
P
S
K
--------------------
P
--------------------
L
L
-----------------------------------
L
S
V
----------------
R
S
G
A
A
I
------
S
--
M
P
G
M
-
M
----
D
T
V
--------
L
N
-----
L
-------------
G
-------
L
-----
N
D
E
V
V
A
G
L
A
G
K
SG
A
R
F
A
Y
D
S
Y
R
R
F
L
D
M
F
G
N
V
V
M
G
I
P
H
S
L
F
D
E
K
L
E
Q
M
K
A
E
K
G
I
H
L
D
T
D
L
T
A
A
D
L
K
D
L
V
---
E
K
-----
Y
---
K
N
V
Y
V
E
A
K
G
E
K
F
P
T
D
P
K
K
Q
L
E
L
A
V
N
A
V
F
D
S
W
D
S
P
R
A
N
K
Y
R
S
I
N
Q
I
T
G
L
K
G
T
-------
A
V
N
I
Q
S
M
V
F
G
N
M
G
N
-
T
S
G
T
G
V
L
F
T
R
N
-
P
S
T
G
E
K
K
L
Y
G
E
--
F
L
I
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
E
D
L
G
T
M
E
T
C
M
P
E
A
Y
K
E
L
V
E
N
----
C
E
I
L
E
R
H
Y
K
---
D
M
M
D
I
E
F
T
V
Q
--
E
N
R
L
W
M
L
Q
C
R
------
T
G
K
R
T
G
K
G
A
V
R
I
A
V
D
M
V
N
E
GL
I
D
T
R
T
A
I
K
---------
R
---------
V
-----------
E
-------
T
--------------
Q
------------
H
---
L
D
Q
L
L
H
PQFEDPSAY
K
---
S
H
V
V
A
T
G
L
P
A
---------------
S
P
G
A
A
V
----------
G
Q
V
C
F
-
S
-
A
E
-
D
A
E
-
T
W
H
A
Q
G
K
S
A
I
L
V
R
T
E
T
S
P
E
D
V
G
G
M
H
A
A
A
G
I
L
T
A
R
G
G
M
T
S
H
A
A
V
V
A
R
G
W
G
K
C
C
V
S
G
C
A
D
------------
I
R
V
N
DD
M
------------
K
------------
I
F
T
I
G
D
R
V
I
K
-----
E
G
D
W
L
S
L
N
G
T
-------
T
G
E
V
I
L
G
K
Q
L
L
A
P
PAM
S
--
N
------
D
L
E
I
F
M
S
-------
W
-------
A
-------
D
-
Q
A
R
R
L
---------------
K
V
M
A
N
A
D
T
P
N
D
A
L
T
A
R
N
N
G
A
Q
G
I
G
L
C
R
T
E
HMF
F
A
S
D
E
R
I
K
A
V
R
-
K
M
I
M
A
V
T
P
E
Q
R
-
K
V
-
A
L
D
L
L
L
P
----------
Y
Q
R
S
D
F
E
G
I
F
R
---
A
M
D
G
L
P
V
--
T
I
R
L
L
D
P
P
L
H
E
F
L
P
E
G
D
L
E
H
I
V
N
E
L
A
V
D
T
GMS
A
------------
D
E
------------
I
Y
----------
S
K
------------------
I
-------
E
-
N
------------------
L
S
E
V
N
P
M
L
G
F
R
G
C
R
L
G
I
--
S
----
Y
P
E
L
T
E
M
Q
V
R
A
I
F
Q
----
A
A
V
S
----
M
T
N
Q
G
-
V
-
T
-
V
I
P
E
----
I
M
V
P
L
V
G
T
P
Q
E
L
R
H
Q
I
S
V
----
I
R
G
V
A
A
N
V
F
------------
A
-
E
M
-----
G
V
T
L
E
Y
K
V
G
T
M
I
E
I
P
R
A
A
L
I
A
E
E
I
G
K
E
A
D
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
Y
S
R
D
DVGKF
L
Q
I
Y
L
A
Q
G
------------
I
--
L
Q
--
H
DPFE----
V
-------
I
D
Q
K
---------------------
G
V
G
Q
L
I
K
M
A
T
E
K
G
R
--
A
------
A
--
N
P
------
S
L
K
V
G
I
C
G
E
H
G
G
E
-
P
S
S
V
A
F
F
D
G
V
G
L
D
Y
V
S
C
S
P
------------------
16
PsiBlast_PDB
61.67
23%
32
- C2 -
-
2DIK
-
PPDK_CLOSY
A:
[17-855]
-----------------------
L
L
G
G
K
G
C
N
L
A
E
M
----
T
I
-
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
-------------
K
Q
I
T
Q
E
-------
I
Q
D
Q
I
-------
F
---------------------------------------
E
A
---------------------------------------
I
---
T
---------
W
L
-
E
E
------------------
L
------
N
------
G
K
KFGDTE
D
P
L
L
V
S
V
R
-----------
S
A
A
R
A
S
M
P
G
M
----------
M
D
------------------------------------
T
--
I
L
N
L
G
L
N
D
V
-----------------------
A
--------
V
E
---------
G
F
--------
A
K
----
K
T
---------------
G
N
P
--------------------
R
--------------------
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
VVMEVPK
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
----------------
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
-
Y
----
K
E
A
--------
M
N
-----
G
E
------------
E
-------
F
PQE
P
K
D
Q
L
M
G
A
-------------------------
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
-
G
T
A
V
N
V
Q
T
M
V
FGN
K
G
-----
E
---
T
S
----
G
T
G
V
A
F
T
R
N
P
S
-------------------
T
G
---------------------------------------------------
E
K
G
I
Y
G
E
--
Y
L
I
N
A
Q
G
E
D
V
V
A
-
G
V
R
T
P
Q
P
I
T
Q
L
---
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
---
D
M
Q
D
M
E
F
T
I
E
--
E
G
K
L
Y
F
L
Q
T
A
NGKRT
A
P
A
A
------------------
L
Q
I
A
C
D
L
----------
V
---------
D
-----------
E
-------
G
--------------
M
------------
I
---
T
E
E
------------
E
---
A
V
V
R
I
E
A
K
S
L
DQLLHPTFN
P
A
A
L
K
A
G
E
V
I
G
S
ALPA
S
P
G
A
A
A
G
K
V
Y
F
-
T
A
D
E
-
A
K
A
-
A
H
E
K
G
-
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
--------------------------------
E
------------
I
K
I
N
E
E
A
K
T
F
E
L
GG
H
T
----
F
A
E
G
D
Y
I
S
L
DGS
T
G
K
I
-----------------------
I
E
T
Q
E
A
-------
S
-------
V
-------
S
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
-----
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
D
R
I
M
K
I
R
K
-
M
I
L
----
S
D
S
V
-
E
A
-
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
-
R
P
M
T
V
R
Y
L
D
P
P
L
HE
F
V
P
H
T
E
E
E
Q
A
E
L
--------------------
A
------------
K
N
------------
M
G
LT
L
A
E
V
K
---
A
K
------------------
V
-------
D
-
E
------------------
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
--
T
----
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
----
T
---
G
-
I
-
D
-
I
V
P
E
----
I
M
I
P
L
V
G
E
K
K
E
L
K
F
---
V
K
D
V
V
V
E
V
A
E
Q
V
K
K
E
-----
K
-----
G
-
S
D
M----
Q
Y
----
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
D
-----------
D
A
GKF
L
D
S
Y
Y
K
A
KI
Y
--
E
S
--
D
--------
P
-------
F
A
R
L
------
D
Q------------
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
R
------
P
--
G
L
------
K
--
C
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
------------------
26
HHSearch
61.49
36%
-98
- C2 -
-
5HV3
1
?
A:
[13-355]
M
K
P
Y
V
L
K
F
-
Q
E
----
I
R
P
H
S
E
A
-
L
V
G
G
K
G
M
N
L
G
A
C
S
N
---
I
-
E
G
V
H
V
P
A
G
F
C
L
T
T
E
A
Y
K
R
T
L
A
E
-----
N
-----
N
-----
E
F
T
Q
L
L
Q
R
-------
L
S
S
L
K
-------
T
---------------------------------------
S
D
---------------------------------------
M
---
D
---------
A
I
-
R
E
------------------
I
------
S
------
E
T
------------
I
R
-----------
T
-------
L
I
----------
Q
H
------------------------------------
T
--
Q
I
P
S
E
I
A
S
Y
-----------------------
M
--------
D
A
---------
T
L
--------
L
D
---
V
G
-----------------
G
Y
--------------------
E
--------------------
M
P
-----------------------------------
F
A
V
----------------
R
S
S
A
T
A
E
D
L
P
H
A
S
--
F
A
G
Q
-
H
----
D
T
Y
--------
L
N
-----
I
I
------------
G
-------
K
-----
D
A
L
L
Q
H
-------------------------
I
S
M
C
W
A
S
L
F
T
E
R
A
I
I
Y
R
I
Q
N
Q
F
D
H
R
K
V
Q
L
A
V
V
I
Q
Q
M
I
---
S
P
-----
E
---------
A
S
G
I
L
F
T
A
D
P
I
-------------------
T
S
N
R
K
S
L
S
I
D
A
S
F
G
L
G
E
A
L
V
S
G
L
V
S
A
D
S
Y
T
V
R
E
N
T
--------
I
T
N
K
I
I
A
T
K
K
L
A
I
Y
S
L
K
--
E
--
G
----
G
T
E
T
-
R
I
L
E
K
S
Q
Q
T
K
Q
T
L
T
D
Q
Q
I
I
Q
L
A
K
L
----
G
R
K
I
E
A
Y
F
G
---
K
P
Q
D
I
E
W
C
L
A
E
--
G
A
F
Y
I
V
Q
S
R
------
P
I
T
------------------
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
61.45
24%
23
- C2 -
-
5JVN
2
PPDK_FLAPR
A:
[15-860]
----------------
G
N
K
D
M
K
S
L
L
G
G
K
G
A
N
L
A
E
M
A
S
-----
I
G
L
S
V
P
P
G
L
T
I
S
T
E
A
C
E
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
------------------
N
------
G
------
K
K
---------------------------------------------------------------------------------------
L
P
P
G
L
W
D
E
-----------------------
I
L
E
G
L
R
Y
V
Q
K
E
---------
M
S
--------
A
S
---
L
G
D
---------------
P
S
K
--------------------
P
--------------------
L
L
-----------------------------------
L
S
V
----------------
R
S
G
A
A
I
------
S
--
M
P
G
M
-
M
----
D
T
V
--------
L
N
-----
L
-------------
G
-------
L
-----
N
D
E
V
V
A
G
L
A
G
K
SG
A
R
F
A
Y
D
S
Y
R
R
F
L
D
M
F
G
N
V
V
M
G
I
P
H
S
L
F
D
E
K
L
E
E
M
K
A
E
K
G
V
H
L
D
T
D
L
T
A
A
D
L
K
D
L
V
---
E
Q
-----
Y
---
K
N
V
Y
V
E
A
K
G
E
K
F
P
T
D
P
K
K
Q
L
E
L
A
V
N
A
V
F
D
S
W
D
S
P
R
A
N
K
Y
R
S
I
N
Q
I
T
G
L
K
G
T
-------
A
V
N
I
Q
C
M
V
F
G
N
M
G
N
-
T
S
G
T
G
V
L
F
T
R
N
-
P
S
T
G
E
K
K
L
Y
G
E
F
L
V
--
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
E
D
L
A
T
M
E
T
C
M
P
E
A
Y
R
E
L
V
E
N
----
C
K
I
L
E
R
H
Y
K
---
D
M
M
D
I
E
F
T
V
Q
--
E
N
R
L
W
M
L
Q
C
R
------
T
G
K
R
T
G
K
G
A
V
R
I
A
V
D
M
V
N
E
GL
I
D
T
R
T
A
I
K
---------
R
---------
V
-----------
E
-------
T
--------------
Q
------------
H
---
L
D
Q
L
L
H
PQFENPSAY
K
---
S
H
V
V
A
T
G
L
P
A
---------------
S
P
G
A
A
V
----------
G
Q
V
V
F
-
S
-
A
E
-
D
A
E
-
T
W
H
A
Q
G
K
S
A
I
L
V
R
T
E
T
S
P
E
D
V
G
G
M
H
A
A
A
G
I
L
T
A
R
G
G
M
T
S
H
A
A
V
V
A
R
G
W
G
K
C
C
V
S
G
C
A
D
------------
I
R
V
N
DD
M
------------
K
------------
V
L
T
I
--
R
V
I
K
-----
E
G
D
W
L
S
L
N
G
S
-------
T
G
E
V
I
L
G
---------
K
Q
L
L
------
A
P
P
A
M
S
N
-------
D
-------
L
-------
E
-
T
F
M
S
W
--------
A
D
Q
V
RR
L
K
V
M
A
N
A
D
T
P
N
D
A
L
T
A
R
N
N
G
A
Q
G
I
G
L
C
R
T
E
HMF
F
A
S
D
E
R
I
K
A
V
R
-
K
M
I
M
A
V
T
--
P
E
-
Q
R
-
K
A
A
L
D
L
L
L
P
--------
Y
Q
R
S
D
F
E
G
I
F
R
---
A
M
D
G
L
P
V
--
T
I
R
L
L
D
P
P
L
H
E
F
L
P
E
G
D
L
E
H
I
V
N
E
L
A
V
D
TGMS
E
------------
D
E
------------
I
Y
----------
S
K
------------------
I
-------
E
-
K
------------------
L
S
E
V
N
P
M
L
G
F
R
G
C
R
L
G
I
--
S
----
Y
P
E
L
T
E
M
Q
V
R
A
I
F
Q
----
A
A
V
S
----
M
N
N
Q
G
-
V
-
T
-
V
I
P
E
----
I
M
V
P
L
V
G
T
P
Q
E
L
R
H
Q
I
G
V
----
I
R
G
V
A
A
N
V
F
------------
A
-
E
M
-----
G
L
T
M
D
Y
K
V
G
T
M
I
E
I
P
R
A
A
L
I
A
E
E
I
A
K
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
Y
S
R
D
DVGKF
L
Q
I
Y
L
S
Q
G
------------
I
--
L
Q
--
H
DPFE----
V
-------
L
D
Q
K
---------------------
G
V
G
Q
L
I
K
M
A
T
E
K
G
R
--
A
------
A
--
N
P
N
L
----
K
--
V
G
I
C
G
E
H
G
G
E
-
P
S
S
V
A
F
F
D
G
V
G
L
D
Y
V
S
C
S
P
------------------
15
PsiBlast_PDB
60.26
24%
46
- C2 -
-
1GGO
-
PPDK_CLOSY
A:
[17-855]
-----------------------
L
L
G
G
K
G
C
N
L
A
E
M
----
T
I
-
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
-----
K
Q----
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
GKKFGDT
E
---------------------------------------
D
P
---------------------------------------
L
---
L
---------
V
S
-
V
R
------------------
S
------
G
------
A
R
------------
A
S
-----------
M
P------
G
M
----------
M
D
------------------------------------
T
--
I
L
N
L
G
L
N
D
V
-----------------------
A
--------
V
E
---------
G
F
--------
A
K
----
K
T
---------------
G
N
P
--------------------
R
--------------------
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
VVMEVP
K
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
----------------
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
-
Y
----
K
E
A
--------
M
N
-----
G
E
------------
E
-------
F
PQE
P
K
D
Q
L
M
G
A
-------------------------
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
-
G
T
A
V
N
V
Q
T
M
V
FGN
K
G
-----
E
---
T
S
----
G
T
G
V
A
F
T
R
N
P
S
-------------------
T
G
---------------------------------------------------
E
K
G
I
Y
G
E
--
Y
L
I
N
A
Q
G
E
D
V
V
A
-
G
V
R
T
P
Q
P
I
T
Q
L
---
E
N
D
M
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
R
---
D
M
Q
D
M
E
F
T
I
E
--
E
G
K
L
Y
F
L
Q
T
R
NGKRT
A
P
A
A
------------------
L
Q
I
A
C
D
L
----------
V
---------
D
-----------
E
-------
G
--------------
M
------------
I
---
T
E
E
------------
E
---
A
V
V
R
I
E
A
K
S
L
DQLLHPTFN
P
A
A
L
K
A
G
E
V
I
G
S
ALPA
S
P
G
AAA
G
K
V
Y
F
-
T
A
D
E
-
A
K
A
-
A
H
E
K
G
-
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
G
I
L
T
V
R
G
G
M
A
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
--------------------------------
E
------------
I
K
I
N
E
E
A
K
T
F
E
L
GG
H
T
----
F
A
E
G
D
YISLDGS
T
G
K
I
-----------------------
I
E
T
Q
E
A
-------
S
-------
V
-------
S
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
-----
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
D
R
I
M
K
I
R
K
-
M
I
L
----
S
D
S
V
-
E
A
-
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
-
R
P
M
T
V
R
Y
L
D
P
P
L
HE
F
V
P
H
T
E
E
E
Q
A
E
L
--------------------
A
------------
K
N
------------
M
G
LT
L
A
E
V
K
---
A
K
------------------
V
-------
D
-
E
------------------
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
--
T
----
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
----
T
---
G
-
I
-
D
-
I
V
P
E
----
I
M
I
P
L
V
G
E
K
K
E
L
K
F
---
V
K
D
V
V
V
E
V
A
E
Q
V
K
K
E
-----
K
-----
G
-
S
D
M
----
Q
Y
----
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
D
-----------
D
A
GKF
L
D
S
Y
Y
K
A
KI
Y
--
E
S
--
D
--------
P
-------
F
A
R
L
------
D
Q------------
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
R
------
P
--
G
L
------
K
--
C
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
------------------
13
PsiBlast_PDB
59.54
24%
31
- C2 -
-
2R82
-
PPDK_CLOSY
A:
[18-856]
-----------------------
L
L
G
G
K
G
C
N
L
A
E
M
----
T
I
-
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
-----
K
Q----
I
T
Q
E
I
Q
D
Q
I
F
E
A
I
T
W
L
E
E
L
N
GKKFGDT
E
---------------------------------------
D
P
---------------------------------------
L
---
L
---------
V
S
-
V
R
------------------
S
------
G
------
A
R
------------
A
S
-----------
M
P------
G
M
----------
M
D
------------------------------------
T
--
I
L
N
L
G
L
N
D
V
-----------------------
A
--------
V
E
---------
G
F
--------
A
K
----
K
T
---------------
G
N
P
--------------------
R
--------------------
F
A
Y
D
S
Y
R
R
F
I
Q
M
Y
S
D
V
VMEVPK
S
H
F
E
K
I
I
D
A
M
K
E
E
K
G
V
H
F
----------------
D
T
D
L
T
A
D
D
L
K
E
L
A
E
K
F
K
A
V
-
Y
----
K
E
A
--------
M
N
-----
G
E
------------
E
-------
F
PQE
P
K
D
Q
L
M
G
A
-------------------------
V
K
A
V
F
R
S
W
D
N
P
E
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
-
G
T
A
V
N
V
Q
T
M
V
F
GN
K
G
-----
E
---
T
S
----
G
T
G
V
A
F
T
R
N
P
D
-------------------
T
G
E
K
G
I
Y
G
R
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
------
Q
P
I
T
-
Q
------
L
E
N
D
M
P
D
C
Y
K
Q
F
M
----------------------------------------
D
L
----
A
M
K
L
E
K
H
F
R
---
D
M
Q
D
M
E
F
T
I
E
--
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
------------------
L
Q
I
A
C
D
L
----------
V
---------
D
-----------
E
-------
G
--------------
M
------------
I
---
T
E
E
------------
E
---
A
V
V
R
I
E
A
K
S
L
D
Q
L
L
H
PTFN
P
A
A
L
K
A
G
E
V
I
G
S
ALPA
S
P
G
A
A
A
G
K
V
Y
F
-
T
A
D
E
-
A
K
A
-
A
H
E
K
G
-
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
--------------------------------
E
------------
I
K
I
N
E
E
A
K
T
F
E
L
GG
H
T
----
F
A
E
G
D
Y
I
S
L
D
GS
T
G
K
I
Y
K
G
-------------------
D
I
E
T
Q
E
A
-------
S
-------
V
-------
S
G
S
F
E
R
I
M
V
W
A
D
K
F
R
T
-----
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
D
R
I
M
K
I
R
K
-
M
I
L
----
S
D
S
V
-
E
A
-
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
-
R
P
M
T
V
R
Y
L
D
P
P
L
HE
F
V
P
H
T
E
E
E
Q
A
E
L
--------------------
A
------------
K
N
------------
M
G
LT
L
A
E
V
K
---
A
K
------------------
V
-------
D
-
E
------------------
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
--
T
----
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
----
T
---
G
-
I
-
D
-
I
V
P
E
----
I
M
I
P
L
V
G
E
K
K
E
L
K
F
---
V
K
D
V
V
V
E
V
A
E
Q
V
K
K
E
-----
K
-----
G
-
S
D
M
----
Q
Y
----
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
D
-----------
D
A
GKF
L
D
S
Y
Y
K
A
KI
Y
--
E
S
--
D
--------
P
-------
F
A
R
L
------
D
Q------------
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
R
------
P
--
G
L
------
K
--
C
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
------------------
44
Fugue
54.12
21%
30
- C2 -
-
1JDE
-
PPDK_CLOSY
A:
[1-873]
-
A
K
W
V
Y
K
F
-
E
E
----
G
N
A
S
M
R
N
-
L
L
G
G
A
G
C
N
L
A
E
M
T
I
L
-----
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
-----
G
-----
K
Q
I
T
Q
E
I
Q
D
Q
I
F
E
A
-------
I
T
W
L
E
-------
E
L
N
G
K
K
F
GDTED
P
L
L
V
S
V
R
S
G
A
RASMPG
M
M
D
T
I
L
NLGLN
D
V
A
---------------------------------------
V
---
E
---------
G
F
-
A
K
------------------
K
T
GNPR
F
A
------
Y
D
------------
S
Y
-----------
R
-------
R
F
----------
I
Q
------------------------------------
M
--
Y
S
D
V
V
M
E
V
P
-----------------------
K
--------
S
H
---------
F
E
--------
K
I
---
I
D
A
---------------
M
K
E
--------------------
E
--------------------
K
G
-----------------------------------
V
H
F
----------------
D
T
D
L
T
A
D
D
L
K
E
L
A
--
E
K
F
K
-
A
----
V
Y
K
--------
E
A
-----
M
N
------------
G
EEFPQEP
K
-----
D
Q
L
M
G
A
-------------------------
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
-
G
T
A
V
N
V
Q
T
M
V
---
F
G
-----
N
---
K
G
ET
S
-
G
T
G
V
A
F
T
R
N
P
S
-------------------
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
Q
L
E
N
D
M
-
P
D
C
Y
K
Q
F
M
D
L
A
M
K
L
E
K
H
F
--------------
R
D
M
Q
D
-
M
E
F
T
I
E
E
G
K
L
Y
F
L
Q
T
R
N
G
K
R
T
-------------------
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
------
V
V
R
------------------
I
E
A
K
S
L
D
Q
---------
L
---------
L
-----------
H
-------
P
--------------
T
------------
F
---
N
P
A
------------
A
L
K
A
G
E
V
I
G
S
A
L
P
A
---------------
S
P
G
A
A
A
----------
G
K
V
Y
F
T
A
-
D
E
-
A
K
A
-
A
H
E
K
G
-
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
------------
I
-----
K
INEEAK
T
F
E
L
GG
H
------------
T
F
A
E
G
D
Y
I
S
L
-----
D
----
G
S
T
G
K
-------
I
-
E
T
Q
E
A
---------
S
--
V
------
S
G
S
F
E
R
I
-------
M
-------
V
-------
W
-
A
D
K
F
R
--------
T
-----
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
---
H
M
F
F
E
A
D
R
I
M
K
-
I
R
K
M
I
L
S
D
S
V
E
-
A
R
-
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
--
F
V
P
H
T
E
E
E
Q
A
E
L
--------------------
A
K
N
M
GLT
L
-----
A
E
------------
V
K
----------
A
K
------------------
V
-------
D
-
E
------------------
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
--
T
YP
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
----
V
K
E
E
----
T
---
G
-
I
-
D
I
V
P
-
E
----
I
M
I
P
L
V
G
E
K
K
E
L
K
F
---
V
----
K
D
V
V
V
E
V
A
E
Q
V
KKEK
G
-----
S
-
D
M
-----
Q
Y
----
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
D
DAGKF
L
D
----
S
Y
------------
Y
--
K
A
--
K
--------
I
-------
Y
E
S
D
PFARLD
Q
-------------
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
--
Q
------
T
--
R
P
G
L
----
K
--
C
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
K
43
Fugue
53.40
22%
33
- C2 -
-
1KBL
-
PPDK_CLOSY
A:
[1-872]
--
A
K
W
V
Y
K
F
E
E
----
G
N
A
S
M
R
N
-
L
L
G
G
K
G
C
N
L
A
E
M
T
I
-----
L
G
M
P
I
P
Q
G
F
T
V
T
T
E
A
C
T
E
Y
Y
N
S
GKQIT
Q
-----
E
-----
I
Q
D
Q
I
F
E
A
-------
I
T
W
L
E
-------
E
---------------------------------------
L
N
GKKFGDT
E
D
P
L
L
V
S
V
R
S
G
A
R
A
S
M
P
GM
M
D
T
I
L
NLGLN
D
V
A
V
---
E
---------
G
F
-
A
K
------------------
K
------
T
------
G
-------------
N
P
-----------
R
-------
F
A
----------
Y
D
------------------------------------
S
Y
R
R
F
I
Q
M
Y
S
D
V
-----------------------
V
--------
M
E
---------
V
P
--------
K
S
---
H
F
E
---------------
K
I
I
--------------------
D
--------------------
A
M
-----------------------------------
K
E
E
----------------
K
G
V
H
F
D
T
D
L
T
A
D
D
--
L
K
E
L
-
A
----
E
K
F
--------
K
A
-----
V
Y
K
E
A
MNGEEFPQE
P
-------
K
-----
D
Q
L
M
G
A
-------------------------
V
K
A
V
F
R
S
W
D
N
P
R
A
I
V
Y
R
R
M
N
D
I
P
G
D
W
-
G
T
A
V
N
V
Q
T
M
V
---
F
G
-----
N
---
K
G
ET
S
-
G
T
G
V
A
F
T
R
N
P
S
-------------------
T
G
E
K
G
I
Y
G
E
Y
L
I
N
A
Q
G
E
D
V
V
A
G
V
R
T
P
Q
P
I
T
Q
--------------------------
L
E
N
--
D
--
M
P
D
C
Y
K
Q
F
M
-
D
L
A
M
K
L
E
K
H
F
R
D
M
Q
D
M
E
F
T
I
E
E
G
K
----
L
Y
F
L
Q
T
R
N
G
K
R
T
A
P
A
A
L
Q
I
A
C
D
L
V
D
E
G
M
I
T
E
E
E
A
------
V
V
R
------------------
I
E
A
K
S
L
D
Q
---------
L
---------
L
-----------
H
-------
P
--------------
T
------------
F
N
P
A
A
L
K
------------
A
---
G
E
V
I
G
S
A
L
P
A
---------------
S
P
G
A
A
A
----------
G
K
V
Y
F
T
A
-
D
E
-
A
K
A
-
A
H
E
K
G
-
E
R
V
I
L
V
R
L
E
T
S
P
E
D
I
E
G
M
H
A
A
E
G
I
L
T
V
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
T
C
C
V
S
G
C
G
E
------------
I
-----
K
------------
I
NEEAK
T
F
E
L
GG
H
T
F
A
E
G
D
Y
I
S
L
-----
D
-----
G
S
T
G
-------
K
I
Y
K
G
D
I
---------
E
--
T
Q
E
A
S
V
S
-
G
S
F
E
R
I
-------
M
-------
V
-------
W
-
A
D
K
F
R
--------
T
-----
L
K
V
R
T
N
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
---
H
M
F
F
------------
E
A
D
R
I
M
K
-
I
R
-
K
M
I
L
S
D
S
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
--
T
V
R
Y
L
D
P
P
L
H
E
F
VPHT
E
E
E
Q
A
E
L
A
K
N
M
GLT--
L
------------
A
E
------------
V
K
----------
A
K
------------------
V
-------
D
-
E
------------------
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
Y
P
--
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
----
V
K
E
E
----
T
---
G
-
I
D
I
-
V
P
-
E
----
I
M
I
P
L
V
G
E
K
K
E
L
K
F
---
V
----
K
D
V
V
V
E
V
A
E
Q
-----
V
-----
K
-
K
E
K
GSD
M
Q
Y
----
H
I
G
T
M
I
E
I
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
D
L
T
Q
M
T
F
G
F
S
R
D
-----------
D
A
------------
G
--
K
F
--
L
--------
D
-------
S
Y
Y
K
------
A
KIYESDPFARLDQ
T
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
--
Q
------
T
--
R
P
G
L
----
K
--
C
G
I
C
G
E
H
G
G
D
-
P
S
S
V
E
F
C
H
K
V
G
L
N
Y
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
-
24
HHSearch
50.12
23%
-
- C- -
-
2X0S
-
?
A:
[2-896]
A
K
K
W
V
Y
Y
F
-
G
G
GNAD
G
N
K
N
M
K
E
-
L
L
G
G
K
G
A
N
L
A
E
M
V
----
N
-
L
G
I
P
V
P
P
G
F
T
I
T
T
E
A
C
K
T
Y
Q
E
T
-----
E
-----
T
-----
I
P
Q
E
V
A
D
Q
-------
V
R
E
--------------------------------------------------
N
---------------------------------------
V
---
S
---------
R
V
E
K
E
------------------
M
------
G
------
A
K
------------
F
G
-----------
D
-------
P
A
N
P
L
L
F
S
V
R
S
G
A
A
------------------------------------
A
--
S
M
----
D
T
V
L
NLGLN
K
V
T
V
D
A
W
V
R
R
APRL
E
R
F
V
--------
Y
D
---------
S
Y
--------
R
R
---
F
I
T
---------------
M
Y
A
D
IVMQVGR
E
D
F
E
E
A
L
S
R
M
K
E
R
--------------------
R
G
-----------------------------------
T
K
F
----------------
D
T
D
L
T
A
S
D
L
K
E
----
L
C
D
G
-
Y
----
L
E
L
F
E
L
KTGCS
F
P
-----
Q
D
------------
P
-------
V
-----
M
Q
L
F
A
A
-------------------------
I
K
A
V
F
R
S
W
G
N
P
R
A
T
I
Y
R
R
M
N
N
I
T
G
-
L
L
G
T
A
V
N
V
Q
A
M
V
---
F
G
NINDR
S
---------
A
T
G
V
A
F
S
R
S
P
S
-------------------
T
G
E
N
F
F
F
G
E
Y
L
V
N
A
Q
G
E
D
V
V
A
G
I
R
T
P
Q
Q
I
N
H
S
L
S
L
R
------
W
A
K
A
H
G
V
G
E
E
E
R
R
------------------------
K
R
Y
P
S
M
E
E
A
M
P
E
N
Y
R
L
L
C
D
V
----
R
K
R
L
E
N
H
Y
R
---
D
M
Q
D
L
E
F
T
V
Q
D
--
G
R
L
W
L
L
Q
C
R
------
N
G
K
------------------
R
T
I
H
A
A
V
R
---------
I
---------
A
I
D
M
V
N
E
GLI--
S
R
E
E
A
V
L
R
I
DPYQ
V
D
H
L
M
H
----
P
N
L
E
---------
P
G--
A
E
K
------------
A
---
N
K
P
I
G
R
G
L
A
A
---------------
S
P
G
A
A
V
----------
G
Q
V
V
F
-
D
-
A
E
S
A
K
E
-
W
S
G
R
G
-
K
K
V
I
M
V
R
L
E
T
S
P
E
D
L
A
G
M
D
A
A
C
G
I
L
T
A
R
G
G
M
T
S
H
A
A
V
V
A
R
G
M
G
K
C
C
V
S
G
C
G
D
------------
M
-----
V
I
R
G
KSFKLNG--
S
------------
V
F
R
E
G
D
Y
I
T
I
------------
D
G
S
-------
K
G
L
I
Y
A
G
---------
K
--
L
------
K
L
R
S
P
D
L
KGS
F
Q
T
I
L
-------
Q
-------
W
-
C
Q
E
M
K
--------
R
-----
L
G
V
R
T
N
A
D
T
P
A
D
A
A
K
A
R
S
F
G
A
E
G
V
G
L
C
R
T
E
---
H
M
F
F
E
G
S
R
I
N
F
I
R
E
M
I
L
A
D
S
A
S
G
-
R
---
K
----------
A
A
L
D
K
L
L
P
I
Q
R
A
D
F
V
G
I
L
R
A
M
R
G
L
P
V
--
T
I
R
L
L
D
P
P
L
H
E
F
--------------------
V
------------
P
H
------------
D
A
----------
A
A
------------------
Q
-------
F
-
E
LAQKLGMPAEK
V
R
N
R
V
N
A
L
H
E
L
N
P
M
L
G
H
R
G
C
R
L
G
I
--
T
--
Y
--
P
E
I
Y
N
M
Q
V
R
A
I
I
E
----
A
A
I
A
V
S
E
-
E
---
G
S
S
-
V
-
I
P
-
E
----
I
M
V
P
L
V
G
K
K
E
E
L
S
L
---
I
----
R
E
E
V
V
K
T
A
E
A
V
I
T
K
-
S
G----
K
-
R
V
-----
H
Y
----
T
V
G
T
M
I
E
V
P
R
A
A
V
T
A
D
S
I
A
Q
K
A
D
F
F
S
F
G
T
N
D
L
T
Q
M
G
C
G
F
S
R
D
-----------
D
A
------------
G
PF
L
R
--
H
--------
Y
G
N
L
GIYA
Q
D
P
F
------
Q
-------------
S
I
D
Q
E
G
I
G
E
L
V
R
I
A
V
--
T
------
K
--
G
R
R
V
KPM
L
K
--
M
G
I
C
G
E
H
G
G
D
-
P
A
T
I
G
F
C
H
K
V
G
L
D
Y
V
S
C
S
P
F
R
V
P
V
A
I
V
A
A
A
H
A
S
I
K
--
2
PsiBlast_PDB
49.34
34%
-6
- C2 -
-
5HV1
1
?
A:
[17-351]
M
K
P
Y
V
L
K
F
-
Q
E
----
I
R
P
H
S
E
A
-
L
V
G
G
K
G
M
N
L
G
A
----
C
S
N
I
E
G
V
H
V
P
A
G
F
C
L
T
T
E
A
Y
K
R
T
L
A
E
-----
N
-----
N
-----
E
F
T
Q
L
L
Q
R
-------
L
S
S
L
K
-------
T
---------------------------------------
S
D
---------------------------------------
M
---
D
---------
A
I
-
R
E
------------------
I
------
S
------
E
T
------------
I
R
-----------
T
-------
L
I
----------
Q
H
------------------------------------
T
--
Q
I
P
S
E
I
A
S
Y
-----------------------
M
--------
D
A
---------
T
L
-------------
L
D
V
---------------
G
G
Y
--------------------
E
--------------------
M
P
-----------------------------------
F
A
V
----------------
R
S
S
A
T
A
E
D
L
P
H
A
S
--
F
A
G
Q
-
H
----
D
T
Y
--------
L
N
-----
I
I
------------
G
-------
K
-----
D
A
L
L
Q
H
-------------------------
I
S
M
C
W
A
S
L
F
T
E
R
A
I
I
Y
R
I
Q
N
Q
F
D
H
R
K
V
Q
L
A
V
V
I
Q
Q
M
I
---
S
P
-----
E
---------
A
S
G
I
L
F
T
A
D
P
I
-------------------
T
S
N
R
K
S
L
S
I
D
A
S
F
G
L
G
E
A
L
V
S
G
L
V
S
A
D
S
Y
T
V
R
--------
E
N
T
I
T
N
K
I
I
A
T
K
K
L
A
I
Y
S
L
K
--
E
--
G
G
T
E
T
R
I
-----
L
E
K
S
Q
Q
T
K
Q
T
L
T
D
Q
Q
I
I
Q
L
A
K
L
----
G
R
K
I
E
A
Y
F
G
---
K
P
Q
D
I
E
W
C
L
--
A
E
G
A
F
Y
I
V
Q
S
R
------
P
I
T
------------------
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
47.01
28%
-52
- C2 -
-
2BG5
-
?
D:
[263-545]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
D
G
K
--------
K
-----
V
M
L
A
A
N
I
G
T
P
K
D
V
A
S
A
L
A
N
G
A
E
G
V
G
L
F
R
T
E
---
F
L
Y
M
D
R
-
N
S
L
P
-
S
E
----
E
E
Q
--------------------
F
E
A
Y
--------
K
E
V
V
E
K
M
G
G
R
P
V
--
T
I
R
T
L
D
I
G
G
D
K
E
--------------------
L
------------
P
Y
------------
L
D
----------------------------------------
M
------------------
P
K
E
M
N
P
F
L
G
Y
R
A
I
R
L
C
L
--
D
--
R
--
P
D
I
F
K
T
Q
L
R
A
I
L
R
----
A
S
A
-----------
Y
-
G
-
N
V
-
Q
----
I
M
Y
P
M
I
S
S
V
E
E
V
R
K
---
A
----
N
S
I
L
E
E
V
K
A
E
LDR--
E
GVK--
Y
-
D
K
-----
E
I
----
K
V
G
I
M
V
E
I
P
S
A
A
V
T
A
D
I
L
A
K
E
V
D
F
F
S
I
G
T
N
D
L
T
Q
Y
T
L
A
V
D
R
M
-----------
N
E
------------
H
--
V
K
--
E
--------
Y
-------
Y
Q
P
F
------
H
-------------
P
A
I
L
R
L
V
K
M
V
I
D
A
A
H
--
K
------
E
--
G
K
------
F
--
A
A
M
C
G
E
M
A
G
D
-
P
L
A
A
V
I
L
L
G
L
G
L
D
E
F
S
M
S
A
T
S
I
P
E
I
K
N
I
I
R
N
V
E
Y
E
--
4
PsiBlast_PDB
46.86
34%
-6
- C2 -
-
5HV3
1
?
A:
[13-355]
M
K
P
Y
V
L
K
F
-
Q
E
----
I
R
P
H
S
E
A
-
L
V
G
G
K
G
M
N
L
G
A
----
C
S
N
I
E
G
V
H
V
P
A
G
F
C
L
T
T
E
A
Y
K
R
T
L
A
E
-----
N
-----
N
-----
E
F
T
Q
L
L
Q
R
-------
L
S
S
L
K
-------
T
---------------------------------------
S
D
---------------------------------------
M
---
D
---------
A
I
-
R
E
------------------
I
------
S
------
E
T
------------
I
R
-----------
T
-------
L
I
----------
Q
H
------------------------------------
T
--
Q
I
P
S
E
I
A
S
Y
-----------------------
M
--------
D
A
---------
T
L
-------------
L
D
V
---------------
G
G
Y
--------------------
E
--------------------
M
P
-----------------------------------
F
A
V
----------------
R
S
S
A
T
A
E
D
L
P
H
A
S
--
F
A
G
Q
-
H
----
D
T
Y
--------
L
N
-----
I
I
------------
G
-------
K
-----
D
A
L
L
Q
H
-------------------------
I
S
M
C
W
A
S
L
F
T
E
R
A
I
I
Y
R
I
Q
N
Q
F
D
H
R
K
V
Q
L
A
V
V
I
Q
Q
M
I
---
S
P
-----
E
---------
A
S
G
I
L
F
T
A
D
P
I
-------------------
T
S
N
R
K
S
L
S
I
D
A
S
F
G
L
G
E
A
L
V
S
G
L
V
S
A
D
S
Y
T
V
R
--------
E
N
T
I
T
N
K
I
I
A
T
K
K
L
A
I
Y
S
L
K
--
E
--
G
G
T
E
T
R
I
-----
L
E
K
S
Q
Q
T
K
Q
T
L
T
D
Q
Q
I
I
Q
L
A
K
L
----
G
R
K
I
E
A
Y
F
G
---
K
P
Q
D
I
E
W
C
L
--
A
E
G
A
F
Y
I
V
Q
S
R
------
P
I
T
------------------
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------