@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VM38: (2017-11-06 )
MKMNTQTHVNSHKQTMAVPNFEVWKNAFVKLLPQHVIKNPVMATVWLGTVVTGISTILGYTTLLFGLVVTAILFITILFANYAEAVAEARGRGQASSLRAARENLTARRLNSLTDRQTTQVAASELHLNDFIEVHAGELVPADGEIVEGFATINESAVTGESAPVLREAGTDLSGVIGGTKVLTDRIVVQVTAESGQSFLDRMIALVEGSNRQKTPNEIALGFLLMVMTITFLIVVISLPFIADYLHIELDPVVLVALLVCLIPTTIGGLLPAIGIAGMNRALKANVLAKSGKAVEVAGDIDVLLLDKTGTITYGDRQATSFYPLTSVTESELRAAAWVSSLADPTPEGKSIVKLAKEQGLKQQEPEQAEFITFSASTRISGVNLPNGDQIRKGALDAILKFVDEDYSQDLELKARVEQVAKKGATPLVVANQHHVLGVIELSDAIKHGIKERFARLREMGIKTVMVTGDNPLTAAAIAAEAGVDDYIAEAKPEDKLACIRTEQQQGRLVAMVGDGTNDAPALAQADIGLAMNSGTQAAKEAGNMVDLDSDPTKLLAVVEIGKQQLITRGALTTFSLANDVSKYFAILPALFAAAIPQMQVLNVMHLASSNSAILSALIFNAIIIPLLIPIALRGVKFKPSTATQLLRRNMLIYGVGGVVLPFLAIKAIDVVIVQLFGL
Atome Classification :
(20 SA)
-------------------------------......--...10........20-------.-------........30........40--------------.........50.-.......60----..-.----.....-----------------.70...--.....80........90........100.......110-..-.....120.......130.......140......---.150---........160......----------.170----------...-------....180......-.190.......200.......210----....-----...220.......230......-.-240----.-..----------.-.--....250------------..-----.--....260.......270.......280.......290.......300.......310...----....320...---...-------------------.------------------------------------330--------------.........340.----------------..-------------------....350.......-360---..--------------------.--------------------....--..370....---...380--......---.---------..390-------.-----........400----------.....----------.---.----.----------.-410.......420-........430.------------------------.------------------------.-----------------------....440.......450.......460.......470.......480.------------------------.-----------------------------------------.------------------------------.-----------------------------------------------------.-----------------..490-----------.------.......500.......510.......520.......530.-......540.......550.......560..--.....570.......580.......590------........600.....-..610-------------........----620....----...630.......640.....--.-.650.......660.......670...-------....-----------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------MKMNTQ--THVNSHKQTMAVP
N
--------
F
-------
E
V
W
K
N
A
F
V
K
L
L
P
Q
H
V
IKNP---------------V
M
A
T
V
W
L
G
T
V
V
T
-
G
I
S
T
I
L
G
Y
-----
T
T
-
L
----
L
F
G
L
V
-----------------
V
T
A
I
L
F
--
I
T
I
L
F
A
N
Y
A
E
A
V
A
E
ARGRG
Q
A
S
S
L
R
A
A
R
E
N
L
T
A
R
R
L
N
S
-
L
T-D
R
Q
T
T
Q
V
A
A
S
EL
H
L
N
D
F
I
E
VHAGELVPADG
E
I
V
E
---
G
F
-A---TINESAVTGESA
P
V
L
R
E----------AGTD----------
L
S
G
-------VIGG
T
K
V
L
T
D
R
I
V
-
V
Q
V
T
A
E
S
G
Q
S
F
L
D
R
M
I
A
L
VEGSNR----QK
T
P
-----
N
E
I
A
L
G
F
L
L
M
V
M
T
I
T
F
L
I
V
V
I
S
-
L
-
P
------
F
-
I
A
----------
D
-
Y
--
L
H
IEL
D
P
------------
V
V
-----
L
--
V
A
L
L
V
C
L
I
P
T
T
I
G
G
L
L
P
A
I
G
I
A
G
M
N
R
A
L
K
A
N
V
LAKSG
K
A
V
E
VAG
D
I
D
V
L
L
LDKT
G
T
I
T
YG----DRQAT
S
F
YPL---TSV-------------------
T
------------------------------------
E
----------------
S
E
L
R
A
A
A
W
V
S
S
LA----------------DP-------------------TPE
G
K
S
I
V
K
L
A
K
EQ-G-----LK--------------------Q--------------------QEPE--QA
E
F
I
T
F
SA---STRI----SGVNLP---
N
---------
G
D
Q
---------
I
-----
R
K
G
A
L
D
A
I
L
------------
K
F
V
DE----------D---Y----S----------Q-
D
L
E
L
K
A
R
V
E
Q
V
A
--KKGAT
P
L
V
V
ANQ------------------------
H
------------------------
H
-----------------------
V
L
G
V
I
E
L
S
D
A
I
K
H
G
I
K
E
R
F
A
R
L
R
EMGI
K
T
V
M
V
TGDNPL
T
A
A
A
I
A
AEAG------------------------V-----------------------------------------
D
------------------------------
D
-----------------------------------------------------
Y
-----------------
I
AEA------------K------PED
K
L
A
C
I
RTEQQQ
G
R
L
V
A
M
VGDGTNDA
P
A
L
A
Q
A
D
I
G
L
AMN-SG
T
Q
A
A
K
EAG
N
M
VDLDSDPTK
L
L
A
V
V
EI
G
K
Q
--
Q
L
I
T
RGA
L
T
T
F
S
L
A
N
D
V
S
K
Y
F
A
I
L
P
A
L
-------
F
A
A
AI
P
Q
M
Q
V
L
N
V
M
HL-ASS-
N
-------------
S
A
I
L
S
A
L
I
----
F
N
A
I
I
I
P
----
L
L
I
P
I
A
LRGVKFKP
S
T
A
T
Q
L
L
--R-RN
M
L
I
Y
GV
G
G
V
V
L
P
F
L
A
I
K
A
I
D
V
V
I
V
Q
-------
L
FGL-----------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.65
57%
-17
- C3 -
-
5MRW
1
?
B:
[11-668]
------------------------------------------------------------------------
K
E
A
V
K
K
L
N
P
Q
A
Q
W
R
N
P
---------------
V
M
F
I
V
W
I
G
S
L
L
T
T
C
I
S
I
A
M
A
S
-----
G
A
-
M
PGNA
L
F
S
A
A
-----------------
I
S
G
W
L
W
--
I
T
V
L
F
A
N
F
A
E
A
L
A
E
G
R
S
K
A
Q
A
N
S
L
K
G
V
K
K
T
A
F
A
R
K
L
R
E
P
K
Y
-
G
A
A
A
D
K
V
P
A
D
Q
L
R
K
G
D
I
V
L
V
E
A
G
D
I
I
P
C
D
G
E
V
I
E
---
G
G
-
A
---
S
V
D
E
S
A
I
T
G
E
S
A
P
V
I
R
E
----------
S
G
G
D
----------
F
A
S
-------
V
T
G
G
T
R
I
L
S
D
W
L
V
-
I
E
C
S
V
N
P
G
E
T
F
L
D
R
M
I
A
M
V
E
G
A
Q
R
----
R
K
T
P
-----
N
E
I
A
L
T
I
L
L
I
A
L
T
I
V
F
L
L
A
T
A
T
-
L
W
P
------
F
-
S
A
------------
W
--
G
G
N
A
V
S
V
------------
T
V
-----
L
--
V
A
L
L
V
C
L
I
P
T
T
I
G
G
L
L
S
A
I
G
V
A
G
M
S
R
M
L
G
A
N
V
I
A
T
S
G
R
A
V
E
A
A
G
D
V
D
V
L
L
L
D
K
T
G
T
I
T
L
G
----
N
R
Q
A
S
E
F
I
P
A
---
Q
G
V
-------------------
D
------------------------------------
E
----------------
K
T
L
A
D
A
A
Q
L
A
S
L
A
----------------
D
E
-------------------
T
P
E
G
R
S
I
V
I
L
A
K
Q
R
F
N
-----
L
R
--------------------
E
--------------------
R
D
V
Q
SL
H
A
T
F
V
P
F
T
A
---
Q
S
R
M
----
S
G
I
N
I
D
---
N
----------
R
M
---------
I
-----
R
K
G
S
V
D
A
I
R
------------
R
H
V
E
A
----------
N
G
G
H
F
----
P
----------
T
-
D
V
D
Q
K
--
V
D
Q
V
A
--
R
Q
G
A
T
P
L
V
V
V
E
G
------------------------
S
------------------------
R
-----------------------
V
L
G
V
I
A
L
K
D
I
V
K
G
G
I
K
E
R
F
A
Q
L
R
K
M
G
I
K
T
V
M
I
T
G
D
N
R
L
T
A
A
A
I
A
A
E
A
G
------------------------
V
-----------------------------------------
D
------------------------------
D
-----------------------------------------------------
F
-----------------
L
A
E
A
------------
T
------
P
E
A
K
L
A
L
I
R
Q
Y
Q
A
E
G
R
L
V
A
M
T
G
D
G
T
N
D
A
P
A
L
A
Q
A
D
V
A
V
A
M
N
-
S
G
T
Q
A
A
K
E
A
G
N
M
V
D
L
D
S
N
P
T
K
L
I
E
V
V
H
I
G
K
Q
--
M
L
M
T
R
G
S
L
T
T
F
S
I
A
N
D
V
A
K
Y
F
A
I
I
P
A
A
-------
F
A
A
T
Y
P
Q
L
N
A
L
N
I
M
C
L
-
H
S
P
-
D
-------------
S
A
I
L
S
A
V
I
----
F
N
A
L
I
I
V
----
F
L
I
P
L
A
L
K
G
V
S
Y
K
P
L
T
A
S
A
M
L
--
R
-
R
N
L
W
I
Y
G
L
G
G
L
L
V
P
F
I
G
I
K
V
I
D
L
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
62.48
57%
-17
- C3 -
-
5MRW
-
?
J:
[5-671]
---------------------------------------------------
L
V
--------
V
-------
Q
A
L
K
E
A
V
K
K
L
N
P
Q
A
Q
W
R
N
P
---------------
V
M
F
I
V
W
I
G
S
L
L
T
-
T
C
I
S
I
A
M
A
SGAMP
G
N
-
A
----
L
F
S
A
A
-----------------
I
S
G
W
L
W
--
I
T
V
L
F
A
N
F
A
E
A
L
A
E
G
R
S
K
A
Q
A
N
S
L
K
G
V
K
K
T
A
F
A
R
K
L
R
E
-
P
K
Y
G
A
A
A
D
K
V
P
A
D
Q
L
R
K
G
D
I
V
L
V
E
A
G
D
I
I
P
C
D
G
E
V
I
E
---
G
G
-
A
---
S
V
D
E
S
A
I
T
G
E
-
A
P
V
I
R
E
----------
S
G
G
D
----------
F
A
S
-------
V
T
G
G
T
R
I
L
S
D
W
L
V
-
I
E
C
S
V
N
P
G
E
T
F
L
D
R
M
I
A
M
V
E
G
A
Q
R
----
R
K
T
P
-----
N
E
I
A
L
T
I
L
L
I
A
L
T
I
V
F
L
L
A
T
A
T
-
L
-
W
------
P
-
F
S
----------
A
-
W
--
G
G
N
A
V
S
V
------------
T
V
-----
L
--
V
A
L
L
V
C
L
I
P
T
T
I
G
G
L
L
S
A
I
G
V
A
G
M
S
R
M
L
G
A
N
V
I
A
T
S
G
R
A
V
E
A
A
G
D
V
D
V
L
L
L
D
K
T
G
T
I
T
L
G
----
N
R
Q
A
S
E
F
I
P
A
---
Q
G
V
-------------------
D
------------------------------------
E
----------------
K
T
L
A
D
A
A
Q
L
A
S
L
A
----------------
D
E
-------------------
T
P
E
G
R
S
I
V
I
L
A
K
Q
R
-
F
-----
N
L
RER-----------------
D
--------------------
V
Q
S
L
--
H
A
T
F
V
P
F
T
A
---
Q
S
R
M
----
S
G
I
N
I
----
D
---------
N
R
M
---------
I
-----
R
K
G
S
V
D
A
I
R
------------
R
H
V
E
A
----------
N
---
G
----
G
----------
H
F
P
T
D
V
D
Q
K
V
D
Q
V
A
--
R
Q
G
A
T
P
L
V
V
V
E
G
------------------------
S
------------------------
R
-----------------------
V
L
G
V
I
A
L
K
D
I
V
K
G
G
I
K
E
R
F
A
Q
L
R
K
M
G
I
K
T
V
M
I
T
G
D
N
R
L
T
A
A
A
I
A
A
E
A
G
------------------------
V
-----------------------------------------
D
------------------------------
D
-----------------------------------------------------
F
-----------------
L
A
E
A
------------
T
------
P
E
A
K
L
A
L
I
R
Q
Y
Q
A
E
G
R
L
V
A
M
T
G
D
G
T
N
D
A
P
A
L
A
Q
A
D
V
A
V
A
M
N
-
S
G
T
Q
A
A
K
E
A
G
N
M
V
D
L
D
S
N
P
T
K
L
I
E
V
V
H
I
G
K
Q
--
M
L
M
T
R
G
S
L
T
T
F
S
I
A
N
D
V
A
K
Y
F
A
I
I
P
A
A
-------
F
A
A
T
Y
P
Q
L
N
A
L
N
I
M
C
L
-
H
S
P
-
D
-------------
S
A
I
L
S
A
V
I
----
F
N
A
L
I
I
V
----
F
L
I
P
L
A
L
K
G
V
S
Y
K
P
L
T
A
S
A
M
L
--
R
-
R
N
L
W
I
Y
G
L
G
G
L
L
V
P
F
I
G
I
K
V
I
D
L
L
L
T
V
-------
C
--------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
60.45
57%
-11
- C3 -
-
5MRW
1
?
F:
[11-668]
------------------------------------------------------------------------
K
E
A
V
K
K
L
N
P
Q
A
Q
W
R
N
P
---------------
V
M
F
I
V
W
I
G
S
L
L
T
T
C
I
S
I
A
M
A
S
-----
G
A
-
M
PGNA
L
F
S
A
A
-----------------
I
S
G
W
L
W
--
I
T
V
L
F
A
N
F
A
E
A
L
A
E
G
R
S
K
A
Q
A
N
S
L
K
G
V
K
K
T
A
F
A
R
K
L
R
E
P
K
Y
-
G
A
A
A
D
K
V
P
A
D
Q
L
R
K
G
D
I
V
L
V
E
A
G
D
I
I
P
C
D
G
E
V
I
E
---
G
G
-
A
---
S
V
D
E
S
A
I
T
G
E
-
A
P
V
I
R
E
----------
S
G
G
D
----------
F
A
S
-------
V
T
G
G
T
R
I
L
S
D
W
L
V
-
I
E
C
S
V
N
P
G
E
T
F
L
D
R
M
I
A
M
V
E
G
A
Q
R
----
R
K
T
P
-----
N
E
I
A
L
T
I
L
L
I
A
L
T
I
V
F
L
L
A
T
A
T
-
L
W
P
------
F
-
S
A
------------
W
--
G
G
N
A
V
S
V
------------
T
V
-----
L
--
V
A
L
L
V
C
L
I
P
T
T
I
G
G
L
L
S
A
I
G
V
A
G
M
S
R
M
L
G
A
N
V
I
A
T
S
G
R
A
V
E
A
A
G
D
V
D
V
L
L
L
D
K
T
G
T
I
T
L
G
----
N
R
Q
A
S
E
F
I
P
A
---
Q
G
V
-------------------
D
------------------------------------
E
----------------
K
T
L
A
D
A
A
Q
L
A
S
L
A
----------------
D
E
-------------------
T
P
E
G
R
S
I
V
I
L
A
K
Q
R
F
N
-----
L
R
--------------------
E
--------------------
R
D
V
Q
SL
H
A
T
F
V
P
F
T
A
---
Q
S
R
M
----
S
G
I
N
I
D
---
N
----------
R
M
---------
I
-----
R
K
G
S
V
D
A
I
R
------------
R
H
V
E
A
----------
N
GGH
F
----
P
----------
T
-
D
V
D
Q
K
--
V
D
Q
V
A
--
R
Q
G
A
T
P
L
V
V
V
E
G
------------------------
S
------------------------
R
-----------------------
V
L
G
V
I
A
L
K
D
I
V
K
G
G
I
K
E
R
F
A
Q
L
R
K
M
G
I
K
T
V
M
I
T
G
D
N
R
L
T
A
A
A
I
A
A
E
A
G
------------------------
V
-----------------------------------------
D
------------------------------
D
-----------------------------------------------------
F
-----------------
L
A
E
A
------------
T
------
P
E
A
K
L
A
L
I
R
Q
Y
Q
A
E
G
R
L
V
A
M
T
G
D
G
T
N
D
A
P
A
L
A
Q
A
D
V
A
V
A
M
N
-
S
G
T
Q
A
A
K
E
A
G
N
M
V
D
L
D
S
N
P
T
K
L
I
E
V
V
H
I
G
K
Q
--
M
L
M
T
R
G
S
L
T
T
F
S
I
A
N
D
V
A
K
Y
F
A
I
I
P
A
A
-------
F
A
A
T
Y
P
Q
L
N
A
L
N
I
M
C
L
-
H
S
P
-
D
-------------
S
A
I
L
S
A
V
I
----
F
N
A
L
I
I
V
----
F
L
I
P
L
A
L
K
G
V
S
Y
K
P
L
T
A
S
A
M
L
--
R
-
R
N
L
W
I
Y
G
L
G
G
L
L
V
P
F
I
G
I
K
V
I
D
L
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
52.86
22%
-4
- C3 -
-
2ZXE
1
?
A:
[97-796]
--------------------------------------------------------------------------------
F
C
R
Q
L
F
G
G
---------------
F
S
I
L
L
W
I
G
A
I
L
C
-
F
L
A
Y
G
I
Q
A
A
TED-
E
P
-
A
----
N
D
N
L
Y
-----------------
L
G
V
V
L
S
--
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
-
Q
Q
A
L
V
I
R
D
-----
G
E
K
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
---
A
H
G
C
---
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
----------
P
E
F
S
SENPLET---
R
N
I
-------
A
F
F
S
T
N
C
V
E
G
T
A
R
-
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
----
G
R
T
P
-----
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
-
F
-
F
------
I
L
S
L
I
---------
L
-
G
--
Y
S
W
L
E
A
V
------------
I
F
-----
L
--
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
----
R
M
T
V
A
H
M
W
F
D
---
N
Q
I
H
E
A
DTTENQSGAAFDKTS
A
T
------------------------------------
W
----------------
S
A
L
S
R
I
A
A
L
C
N
R
A
V
F
Q
A
GQDNVPILKRSV
A
G
-------------------
D
A
S
E
S
A
L
L
K
C
I
E
L
C
-
C
-----
G
S
V
Q
G
M
----------------
R
--------------------
D
R
N
P
--
K
I
V
E
I
P
F
N
S
---
T
N
K
Y
----
Q
L
S
I
H
E
---
N
EKSSES
R
--
Y
L
L
---------
V
-----
M
K
G
A
P
E
R
I
L
------------
D
R
C
S
T
----------
I
---
L
----
L
NG
A
E
E
P
LK
E
D
M
-
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
L
G
E
R
V
L
G
F
C
H
F
ALPEDKYNEG
Y
P
F
D
ADEPNFPTTD
L
------------------------
C
-----------------------
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
------------------------
I
-----------------------------------------
I
------------------------------
S
EGNET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
L
H
Y
H
T
E
I
V
-----------------
F
A
R
T
------------
S
------
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
--
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Fugue
51.74
26%
-21
- C4 -
-
3RFU
-
COPA_LEGPH
A:
[74-736]
VSP
E
Y
L
D
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
GHG
L
K
H
F
I
S
--
G
N
G
S
S
W
I
Q
L
L
L
A
T
P
--------
V
-------
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
---------------
Q
L
N
M
F
T
L
I
A
M
G
I
-
G
V
A
W
I
Y
S
M
-----
V
A
-
V
----
L
W
P
G
V
FPHAFRSQEGVVAVY
F
E
A
A
A
V
I
T
--
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
-
S
A
H
R
I
K
E
----
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
---
G
R
-
S
---
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
----------
A
S
-------------
A
K
-------
V
I
G
A
T
I
N
Q
T
G
S
F
V
-
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
----
S
R
A
P
I
Q
R
L
-
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
-
W
-
A
------
L
-
L
G
----------
P
-
Q
--
P
A
L
S
Y
G
L
------------
I
A
-----
A
--
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
----
H
P
K
L
T
R
I
V
T
D
---
D
F
V
-------------------
E
------------------------------------
D
----------------
N
A
L
A
L
A
A
A
L
E
H
-
Q
----------------
S
E
-------------------
H
P
L
A
N
A
I
V
H
A
A
K
E
K
-
G
-----
L
S
--------------------
L
--------------------
G
S
V
E
--
A
-----
F
E
A
---
P
T
G
K
----
G
V
V
G
Q
V
---
D
---------
G
H
H
---------
V
-----
A
I
G
N
----
A
------------
R
L
M
Q
E
----------
H
---
G
----
G
----------
D
-
N
A
P
L
F
E
K
A
D
E
L
R
--
G
K
G
A
S
V
M
F
M
A
V
D
------------------------
G
------------------------
K
-----------------------
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
------------------------
I
-----------------------------------------
K
------------------------------
K
-----------------------------------------------------
V
-----------------
V
A
E
I
------------
M
------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
------------------
R
G
-------------------------------------
I
A
K
A
R
R
L
-
S
E
S
-
T
-------------
M
S
N
I
R
Q
N
L
----
F
F
A
F
I
Y
N
----
V
L
G
V
P
L
A
A
G
V
L
Y
P
L
---
T
G
L
L
--
L
-
S
P
M
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
-------
L
--------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
50.59
20%
3
* C3 *
-
3AR4
4
AT2A1_RABIT
A:
[54-779]
--------------------------------------------------------------------------------
V
I
E
Q
F
E
D
L
---------------
L
V
R
I
L
L
L
A
A
C
I
S
-
F
V
L
A
W
F
E
E
-----
G
E
E
T
----
I
T
A
F
V
-----------------
E
P
F
V
I
L
--
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
-
E
M
G
K
V
Y
R
A
--
D
-
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
IKS
T
T
-
L
---
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
----------
T
E
P
V
PDPRAVNQDK
K
N
M
-------
L
F
S
G
T
N
I
A
A
G
K
A
L
-
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
----
D
K
T
P
-----
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
-
V
-
W
L
I
----
N
-
I
G
HFNDPVHGGS
W
-
I
--
R
G
A
I
Y
Y
F
------------
K
I
-----
A
--
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
----
Q
M
S
V
C
K
M
F
I
I
---
D
K
V
-------------------
D
GD
F
C
S
L
N
E
F
S
I
T
G
STYAPE
G
E
V
L
K
ND
K
P
I
R
SGQF
D
G
L
----------------
V
E
L
A
T
I
C
A
L
C
N
D
S
S
L
D
F
NETKG
V
Y
E
K
---
V
G
-------------------
E
A
T
E
T
A
L
T
T
L
V
E
K
M
-
N
-----
V
F
--------------------
N
TEVRNLS
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
M
K
--
K
E
F
T
L
E
F
S
R
---
D
R
K
S
----
M
S
V
Y
C
S
---
P
AKSSRAA
V
G
N
K
M
---------
F
-----
V
K
G
A
P
E
G
V
I
------------
D
R
C
N
Y
----------
V
---
R
----
V
GT
T
R
V
P
MT
G
P
V
-
K
E
K
I
L
S
V
I
K
E
W
G
TG
R
D
T
L
R
C
L
A
L
A
T
R
DTPPKREEMVLDDSSR
F
M
E
Y
E
TD-
L
------------------------
T
-----------------------
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
------------------------
I
-----------------------------------------
F
------------------------------
G
ENEEVADRAYT
G
R
E
F
D
D
LP
L
A
E
Q
R
E
A
C
R
R
AC----------------------
C
-----------------
F
A
R
V
------------
E
------
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
--
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
50.00
30%
13
- C3 -
-
3J09
-
COPA_ARCFU
A:
[205-707]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
V
V
-
I
R
-
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
---
G
E
-
S
---
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
----------
K
G
D
E
----------
V
F
G
A------
T
I
N
N
T
G
V
L
K
-----
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
----
S
K
P
P
-----
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
---
A
------
F
-
I
Y
----------
W
-
Y
--
F
-
I
A
H
A
P
------------
L
L
FAFTT
L
--
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
----
K
P
E
V
T
D
L
V
P
L
---
N
G
--------------------
D
------------------------------------
E
----------------
R
E
L
L
R
L
A
A
I
A
E
R
R
----------------
S
E
-------------------
H
P
I
A
E
A
I
V
K
K
A
L
E
H
-
G
-----
I
E
--------------------
L
--------------------
G
E
P
E
--
K
V
E
V
I
A
---------------------------------
G
E
G
---------
V
--------
V
A
D
G
I
L
V
G
N
---------
K
R
L
M
E
----------
D
---
F
G
V
A
V
S
----------
N
-
E
V
E
L
A
--
L
E
K
L
E
--
R
E
A
K
T
A
V
I
V
A
R
N
------------------------
G
------------------------
R
-----------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
------------------------
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
-----------------
I
A
E
V
------------
L
------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
--
T
------------------------------------------------
M
-
S
K
I
-
K
-------------
Q
N
I
F
W
A
L
I
----
Y
N
V
I
L
I
P
A
A
A
G
L
L
Y
P
I
F
--
G
V
V
F
R
P
E
F
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
48.72
21%
9
- C3 -
-
5KSD
1
PMA2_ARATH
B:
[50-649]
--------------------------------------------------------------------------------
F
L
G
F
M
W
N
P
---------------
L
S
W
V
M
E
M
A
A
I
M
A
-
I
A
L
A
N
G
D
G
RP---
P
D
-
W
----
Q
D
F
V
G
-----------------
I
----
I
--
C
L
L
V
I
N
S
T
I
S
F
I
E
E
N
N
A
G
N
A
A
A
A
L
M
A
G
L
A
-
P
K
T
K
V
L
R
D
-----
G
K
W
S
E
Q
E
A
A
I
L
V
P
G
D
I
V
S
I
K
L
G
D
I
I
P
A
D
A
R
L
L
E
---
G
D
P
L
---
K
V
D
Q
S
A
L
T
G
E
S
L
P
V
T
K
H
----------
P
G
Q
-------------
E
-------
V
F
S
G
S
T
C
K
Q
G
E
I
E
-
A
V
V
I
A
T
G
V
H
T
F
F
G
K
A
A
H
L
V
D
S
-
T
N
----
Q
V
G
H
-----
F
Q
K
V
L
T
A
I
G
N
F
C
I
C
S
I
A
I
G
M
V
I
-
E
-
I
------
I
-
V
M
----------
Y
P
I
QR
R
K
Y
R
D
G
I
------------
D
N
-----
L
--
L
V
L
L
I
G
G
I
P
I
A
M
P
T
V
L
S
V
T
M
A
I
G
S
H
R
L
S
Q
Q
G
A
I
T
K
R
M
T
A
I
E
E
M
A
G
M
D
V
L
C
S
D
K
T
G
T
L
T
L
N
----
K
L
S
V
D
K
N
L
V
E
VFC
K
G
V
-------------------
E
------------------------------------
K
----------------
D
Q
V
L
L
F
A
A
M
A
S
R
V
E---------------
N
Q
-------------------
D
A
I
D
A
A
M
V
G
M
L
A
D
P
-
K
-----
E
A
--------------------
R
--------------------
A
G
I
R
--
E
V
H
F
L
P
F
N
P
---
V
D
K
R
----
T
A
L
T
Y
I
---
D
GSGN-----
W
H
R
---------
V
-----
S
K
G
A
P
E
Q
I
L
------------
E
L
A
K
A
----------
S
---
N
----
D
----------
L
-
S
K
K
V
L
S
I
I
D
K
Y
A
--
E
R
G
L
R
S
L
A
V
A
R
Q
VVPEKTKESPGAP-----------
W
------------------------
E
-----------------------
F
V
G
L
L
P
L
F
D
P
P
R
H
D
S
A
E
T
I
R
R
A
L
N
L
G
V
N
V
K
M
I
T
G
D
Q
L
A
I
G
K
E
T
G
R
R
L
G
------------------------
M
-----------------------------------------
G
TNMYPSSALLGTHKDANLASIPVEELIEKA
D
-----------------------------------------------------
G
-----------------
F
A
G
V
------------
F
------
P
E
H
K
Y
E
I
V
K
K
L
Q
E
R
K
H
I
V
G
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
D
I
G
I
A
V
A
-
D
A
T
D
A
A
R
G
A
S
D
I
V
L
T
E
P
G
L
S
V
I
I
S
A
V
L
T
S
R
A
--
I
F
Q
R
M
K
N
Y
T
I
Y
A
V
S
I
T
I
R
I
V
F
G
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Fugue
48.40
20%
-5
- C3 -
-
1SU4
-
AT2A1_RABIT
A:
[1-994]
----------------MEAAHSKS
T
E
E
C
L
A
Y
F
G
V
S
E
T
--
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
--------
Y
GHN
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
--
E
D
L
---------------
L
V
R
I
L
L
L
A
A
C
I
S
-
F
V
L
A
W
F
E
E
-----
G
E
-
E
----
T
I
T
A
F
-----------------
V
E
P
F
V
I
--
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
--
D
-
R
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
---
I
K
-
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
TEPVPDPRAV
N
Q
D
K
----------
K
N
M
-------
L
F
S
G
T
N
I
A
A
G
K
A
L
-
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
----
D
K
T
P
-----
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
-
V
-
W
------
L
-
I
N
----------
I
-
G
--
H
F
N
D
P
V
H
GGSWI
R
G
A
I
Y
Y
F
K
I
-----
A
--
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
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V
I
C
S
D
K
T
G
T
L
T
T
N
----
Q
M
S
V
C
K
M
F
I
I
---
D
K
V
-------------------
D
GD
F
C
S
L
N
E
F
S
I
T
G
S
T
YAP
E
G
E
V
L
K
ND
K
P
I
R
SGQ---
F
----------------
D
G
L
V
E
L
A
T
I
C
A
L
C
----------------
N
D
S
S
L
D
F
NETKG
V
Y
E
K
V
G
---
E
A
T
E
T
A
L
T
T
L
V
E
K
M
-
N
-----
V
F
NTEVRNLSKVERAN
A
C
N
S
V
I
R
--------------------
Q
L
M
K
--
K
E
F
T
L
E
F
S
R
---
D
R
K
S
----
M
S
V
Y
C
S
---
P
---------
A
K
S
SRAAVG
N
K
M
F
-----
V
K
G
A
P
E
G
V
I
D
R
CN
Y
V
R
V
GT
T
R
V
P
M
T
G
----------
P
---
V
----
K
----------
E
-
K
I
L
S
V
I
K
E
W
G
T
G
--
R
D
T
L
R
C
L
A
L
A
T
R
------------------------
D
------------------------
T
PPKREEMVLDDSSR
F
M
E
Y
E
TD
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
------------------------
I
FGENEEVADRAYT
G
---------------------------
R
------------------------------
E
-----------------------------------------------------
F
D
D
LP
L
A
E
Q
R
E
A
C
R
R
ACC
F
A
R
V
------------
E
------
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
--
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
-------
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
-
N
L
V
T
D
-------------
G
L
P
A
T
A
L
G
----
F
N
------------
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
IS
G
-
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
M
Y
-------
A
E
D
G
PGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
LSENQSLMRMPPWVN
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
YV
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
YLEG-----
128
HHSearch
48.27
30%
6
- C4 -
-
4UMW
-
ZNTA_SHISS
A:
[203-694]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
M
V
L
--
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
-
E
T
A
T
R
L
R
N
-----
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
---
P
F
-
A
---
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
----------
T
G
D
-------------
K
-------
V
P
A
G
A
T
S
V
D
R
L
V
T
-
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
----
R
R
A
P
-----
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
-
L
------
V
-
P
P
----------
L
-
L
FA
A
S
W
Q
E
W
I
------------
Y
K
-----
G
--
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
----
K
P
R
V
T
A
I
H
P
A
---
T
G
I
-------------------
S
------------------------------------
E
----------------
S
E
L
L
T
L
A
A
A
V
E
Q
G
----------------
A
T
-------------------
H
P
L
A
Q
A
I
V
R
E
A
Q
V
A
-
E
-----
L
A
--------------------------------------------------
I
P
T
A
E
S
---
Q
R
A
L
----
V
G
S
G
I
E
A
Q
V
N
---------
G
E
R
---------
V
-----
L
I
C
A
A
G
K
--------------------------------------
H
----------
P
-
A
D
A
F
A
G
L
I
N
E
L
E
--
S
A
G
Q
T
V
V
L
V
V
R
N
------------------------
D
------------------------
D
-----------------------
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
------------------------
L
-----------------------------------------
E
------------------------------------------------------------------------------------
F
-----------------
K
A
G
L
------------
L
------
P
E
D
K
V
K
A
V
T
K
L
N
Q
-
H
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
--
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Fugue
47.24
25%
-14
- C4 -
-
4UMW
-
ZNTA_SHISS
A:
[124-730]
-------------------------------
R
L
K
E
N
L
--
P
L
I
T
L
I
V
M
M
A
I
S
W
G
--------
L
-------
E
Q
F
N
H
P
F
G
Q
L
A
F
I
A
T
T
L
V
G
---------------
L
Y
P
I
A
R
Q
A
L
R
L
I
-
K
S
G
S
Y
F
A
I
-----
E
T
-
L
----
M
S
V
A
A
-----------------
I
G
A
L
F
I
GA
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
V
S
A
L
M
A
L
K
P
E
T
A
T
R
-
L
R
-
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
---
P
F
-
A
---
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
----------
T
G
D
K
----------
V
P
A
----------
G
A
T
S
V
D
R
L
V
T
-
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
----
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
-
P
-
L
------
L
-
F
A
----------
A
-
S
--
W
Q
E
W
I
Y
K
------------
G
L
-----
T
--
L
L
L
I
G
C
--
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
----
K
P
R
V
T
A
I
H
P
A
---
T
G
I
-------------------
S
------------------------------------
E
----------------
S
E
L
L
T
L
A
A
A
V
E
Q
G
----------------
A
T
-------------------
H
P
L
A
Q
A
I
V
R
E
A
Q
V
A
-
E
-----
L
A
--------------------
I
--------------------
P
T
A
E
--
S
Q
R
A
L
V
---------------------------------
G
S
G
---------
I
-----
E
A
Q
V
N
G
E
R
V
------------
L
I
C
A
A
----------
G
---
K
----
H
----------
P
-
A
D
A
F
A
G
L
I
N
E
L
E
--
S
A
G
Q
T
V
V
L
V
V
R
N
------------------------
D
------------------------
D
-----------------------
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
------------------------
L
------------------------------------------------------------------------
E
-----------------------------------------------------
F
-----------------
K
A
G
L
------------
L
------
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
P
-
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
---------------------------
A
A
L
T
----
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
-------
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
-
L
K
G
-
I
-------------
F
L
V
T
T
L
L
G
----
M
T
G
--------------
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
--
T
-
A
N
A
L
R
L
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
47.14
30%
24
- C3 -
-
3J08
-
COPA_ARCFU
A:
[205-707]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
V
V
-
I
R
-
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
---
G
E
-
S
---
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
----------
K
G
D
E
----------
V
F
G
A------
T
I
N
N
T
G
V
L
K
-----
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
----
S
K
P
P
-----
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
---
A
------
F
-
I
Y
----------
W
-
Y
--
F
-
I
A
H
A
P
------------
L
L
FAFTT
L
--
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
----
K
P
E
V
T
D
L
V
P
L
---
N
G
--------------------
D
------------------------------------
E
----------------
R
E
L
L
R
L
A
A
I
A
E
R
R
----------------
S
E
-------------------
H
P
I
A
E
A
I
V
K
K
A
L
E
H
-
G
-----
I
E
--------------------
L
--------------------
G
E
P
E
--
K
V
E
V
I
A
---------------------------------
G
E
G
---------
V
--------
V
A
D
G
I
L
V
G
N
---------
K
R
L
M
E
----------
D
---
F
G
V
A
V
S
----------
N
-
E
V
E
L
A
--
L
E
K
L
E
--
R
E
A
K
T
A
V
I
V
A
R
N
------------------------
G
------------------------
R
-----------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
------------------------
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
-----------------
I
A
E
V
------------
L
------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
--
T
------------------------------------------------
M
-
S
K
I
-
K
-------------
Q
N
I
F
W
A
L
I
----
Y
N
V
I
L
I
P
A
A
A
G
L
L
Y
P
I
F
--
G
V
V
F
R
P
E
F
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
46.48
34%
-85
- C4 -
-
3SKY
1
A:
[5-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
F
E
R
A
K
D
L
Q
A
V
I
F
D
K
T
G
T
L
T
E
G
----
R
F
G
V
T
D
I
V
G
F
----
N
H
-------------------
S
------------------------------------
E
----------------
D
E
L
L
Q
I
A
A
S
L
E
A
R
----------------
S
E
-------------------
H
P
I
A
A
A
I
V
E
E
A
E
K
R
-
G
-----
F
G
--------------------
L
--------------------
T
E
V
E
-------
E
F
R
A
---
I
P
G
K
----
G
V
E
G
I
V
---
N
---------
G
R
R
---------
Y
-----
M
V
V
S
P
G
Y
I
R
------------
E
L
G
-----------------------------------
I
K
T
D
E
S
V
E
K
L
K
--
Q
Q
G
K
T
V
V
F
I
L
K
N
------------------------
G
------------------------
E
-----------------------
V
S
G
V
I
A
L
A
D
R
I
R
P
E
S
R
E
A
I
S
K
L
K
A
I
G
I
K
C
M
M
L
T
G
D
N
R
F
V
A
K
W
V
A
E
E
L
G
------------------------
L
-----------------------------------------
D
------------------------------
D
-----------------------------------------------------
Y
-----------------
F
A
E
V
------------
L
------
P
H
E
K
A
E
K
V
K
E
V
Q
Q
-
K
Y
V
T
A
M
V
G
D
G
V
N
D
A
P
A
L
A
Q
A
D
V
G
I
A
I
G
-
A
G
T
D
V
A
V
E
T
A
D
I
V
L
V
R
N
D
P
R
D
V
A
A
I
V
E
L
S
R
K
--
T
Y
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Fugue
46.47
21%
-7
- C3 -
-
5KSD
2
PMA2_ARATH
A:
[1-833]
-----------------VDLEKIPIE
E
V
F
Q
Q
L
K
C
S
R
E
GL
T
T
Q
E
G
E
D
R
I
Q
I
F
G
P
--------
N
-------
K
L
E
E
K
K
E
S
K
L
L
K
F
L
G
F
M
W
N
---------------
P
L
S
W
V
M
E
M
A
A
I
M
-
A
I
A
L
A
N
G
D
-----
G
R
-
P
----
P
D
W
Q
D
-----------------
F
V
G
I
I
C
--
L
L
V
I
N
S
T
I
S
F
I
E
E
N
N
A
G
N
A
A
A
A
L
M
A
G
L
A
P
K
T
K
V
L
R
-------
D
G
K
W
S
E
Q
E
A
A
I
L
V
P
G
D
I
V
S
I
K
L
G
D
I
I
P
A
D
A
R
L
L
E
---
G
D
P
L
---
K
V
D
Q
S
A
L
T
G
E
S
L
P
V
T
K
H
----------
P
G
-------------
Q
E
-------
V
F
S
G
S
T
C
K
Q
G
E
I
E
-
A
V
V
I
A
T
G
V
H
T
F
F
G
K
A
A
H
L
V
D
S
T
N
Q
VG
H
F
Q
K
V
L
-----
T
A
I
G
-
N
F
C
I
C
S
I
A
I
G
M
V
I
E
I
I
V
-
M
-
Y
------
P
-
I
Q
----------
R
-
R
--
K
Y
R
D
G
I
D
------------
N
L
-----
L
--
V
L
L
I
G
G
-
I
P
I
A
M
P
T
V
L
S
V
T
M
A
I
G
S
H
R
L
S
Q
Q
G
A
I
T
K
R
M
T
A
I
E
E
M
A
G
M
D
V
L
C
S
D
K
T
G
T
L
T
L
N
KLSV
D
K
N
L
V
E
V
F
C
K
---
G
V
E
-------------------
K
------------------------------------
D
----------------
Q
V
L
L
F
A
A
M
A
S
R
V
E
----------------
N
Q
-------------------
D
A
I
D
A
A
M
V
G
M
L
A
D
P
-
K
-----
E
A
--------------------
R
--------------------
A
G
I
R
--
E
V
H
F
L
P
F
N
P
VDK
R
T
A
L
----
T
Y
I
D
G
S
G
--
N
---------
W
H
R
---------
V
-----
S
K
G
A
P
E
Q
I
L
------------
E
L
A
K
A
----------
S
---
N
----
D
----------
L
-
S
K
K
V
L
S
I
I
D
K
Y
A
--
E
R
G
L
R
S
L
A
V
A
R
Q
V
V
PEKTKESPGAP-----------
W
------------------------
E
-----------------------
F
V
G
L
L
P
L
F
D
P
P
R
H
D
S
A
E
T
I
R
R
A
L
N
L
G
V
N
V
K
M
I
T
G
D
Q
L
A
I
G
K
E
T
G
R
R
L
G
MGTNMYPSSALLGTHKDANLASIP
V
-----------------------------------------
E
------------------------------
E
-----------------------------------------------------
L
-----------------
I
E
K
A
------------
D
G
F
A
GVF
P
E
H
K
Y
E
I
V
K
K
L
Q
E
R
K
H
I
V
G
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
D
I
G
I
A
V
A
-
D
A
T
D
A
A
R
G
A
S
D
I
V
L
T
E
P
G
L
S
V
I
I
S
A
V
L
T
S
R
A
I
F
Q
R
M
K
N
Y
T
I
Y
A
V
S
I
T
I
R
I
V
F
G
F
M
L
I
A
L
I
WEFDFS
A
F
M
V
L
I
I
A
I
L
N
D
G
T
I
M
T
-
I
S
K
-
D
R
V
K
P
S
PTPDSWK
L
K
E
I
F
A
T
G
V
V
L
G
G
Y
Q
A
I
M
T
V
----
I
F
F
W
A
A
H
K
T
D
F
F
S
D
T
F
G
V
R
S
I
--
R
D
N
N
H
E
L
M
G
A
V
Y
L
Q
V
S
I
I
S
Q
A
L
I
F
V
T
R
S
R
-------
S
W
S
F
VERPG
A
L
L
M
I
A
F
L
I
A
Q
L
I
A
T
L
I
A
V
YANWEFAK
I
R
G
I
G
W
G
W
A
G
V
I
W
L
Y
S
I
V
T
Y
F
P
L
D
V
F
K
F
A
I
R
YI------------------------------------------------------------------------
131
HHSearch
45.26
33%
-90
- C4 -
-
3SKX
-
A:
[5-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
F
E
R
A
K
D
L
Q
A
V
I
F
D
K
T
G
T
L
T
E
G
----
R
F
G
V
T
D
I
V
G
F
----
N
H
-------------------
S
------------------------------------
E
----------------
D
E
L
L
Q
I
A
A
S
L
E
A
R
----------------
S
E
-------------------
H
P
I
A
A
A
I
V
E
E
A
E
K
R
-
G
-----
F
G
--------------------
L
--------------------
T
-------
E
V
E
E
F
R
A
---
I
P
G
K
----
G
V
E
G
I
V
---
N
---------
G
R
R
---------
Y
-----
M
V
V
S
P
G
Y
I
R
------------
E
L
G
-----------------------------------
I
K
T
D
E
S
V
E
K
L
K
--
Q
Q
G
K
T
V
V
F
I
L
K
N
------------------------
G
------------------------
E
-----------------------
V
S
G
V
I
A
L
A
D
R
I
R
P
E
S
R
E
A
I
S
K
L
K
A
I
G
I
K
C
M
M
L
T
G
D
N
R
F
V
A
K
W
V
A
E
E
L
G
------------------------
L
-----------------------------------------
D
------------------------------
D
-----------------------------------------------------
Y
-----------------
F
A
E
V
------------
L
------
P
H
E
K
A
E
K
V
K
E
V
Q
Q
-
K
Y
V
T
A
M
V
G
D
G
V
N
D
A
P
A
L
A
Q
A
D
V
G
I
A
I
G
-
A
G
T
D
V
A
V
E
T
A
D
I
V
L
V
R
N
D
P
R
D
V
A
A
I
V
E
L
S
R
K
--
T
Y
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Fugue
44.25
19%
-28
- C3 -
-
3B8E
2
AT1A1_PIG
A:
[1-998]
--------------------AKKERDMDELK
K
E
V
S
M
D
--
D
H
K
L
S
L
D
E
L
H
R
K
Y
G
TDLSRGLT
P
-------
A
R
A
A
E
I
L
A
R
D
G
P
N
A
L
T
P
P
P
TTPEWVKFCRQLFGG
F
S
M
L
L
W
I
G
A
I
L
C
-
F
L
A
Y
G
I
Q
A
-----
A
T
-
E
----
E
E
P
Q
N
-----------------
D
N
L
Y
L
G
--
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
Q
A
L
V
-
I
R
-
N
G
E
K
M
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
---
A
N
G
C
---
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
----------
P
D
F
T
----------
N
E
N
PLETRNI
A
F
F
S
T
N
C
V
E
G
T
A
R
-
G
I
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
G
----
G
Q
T
P
-----
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
-
F
-
F
------
I
-
L
S
----------
L
-
I
--
L
E
Y
T
W
L
E
------------
A
V
-----
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
----
R
M
T
V
A
H
M
W
S
D
---
N
Q
I
-------------------
H
------------------------------------
E
A
DTTENQSGVSFDKTS
A
T
W
L
A
L
S
R
I
A
G
L
C
----------------
N
R
A
V
F
Q
A
NQENLPILK
R
A
V
A
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
-
C
GS
V
K
E
M
R
--------------------
E
--------------------
R
Y
T
K
--
I
V
E
I
P
F
N
S
T
---
N
K
Y
Q
----
L
S
I
H
K
N
---
P
---------
N
T
A
EPR
H
L
L
---
V
-----
M
K
G
A
P
E
R
I
L
------------
D
R
C
S
S
I
L
I
HGKEQPL
D
---
E
----
E
----------
L
-
K
D
A
F
Q
N
A
Y
L
E
L
G
--
G
L
G
E
R
V
L
G
F
C
H
L
------------------------
F
L
P
DEQFPEGF
Q
F
D
T
DDVNFPLDN
L
C
-----------------------
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
------------------------
I
ISEGN
E
T
V
E
D
IAARLNIPVSQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
MT
S
------------------------------
E
-----------------------------------------------------
Q
-----------------
L
D
D
I
L
K
YHTEIVFART
S
------
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
S
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
--
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
I
F
I
-------
I
A
N
I
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
-
D
-------------
M
V
P
A
I
S
L
A
----
Y
E
----
Q
----
A
E
S
D
I
M
K
R
Q
P
R
N
P
K
T
D
K
L
V
N
E
--
Q
-
L
I
S
M
A
Y
G
Q
I
G
M
I
Q
A
L
G
G
F
F
T
Y
F
V
I
L
A
E
N
GFLPIH
L
L
G
L
R
V
N
WDDRWINDVEDSYG
Q
Q
W
T
Y
EQRKIVEFT
C
H
T
P
F
F
V
T
I
V
V
V
Q
W
A
D
L
V
I
C
KTRRNSVFQQGMKN
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
CPGMGVA
L
R
M
Y
P
LKPTWWFCAFPY
S
L
L
I
F
V
Y
D
E
V
R
K
L
I
I
R
R
RPGGW
V
E
K
E
T
YY
9
PsiBlast_PDB
43.80
33%
-1
- C4 -
-
3A1E
1
COPA_ARCFU
A:
[14-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
----
K
P
E
V
T
D
L
V
P
L
---
N
G
--------------------
D
------------------------------------
E
----------------
R
E
L
L
R
L
A
A
I
A
E
R
R
----------------
S
E
-------------------
Q
P
I
A
E
A
I
V
K
K
A
L
E
H
-
G
-----
I
E
--------------------
L
--------------------
G
E
P
E
--
K
V
E
V
I
A
G
E
G
---
V
V
-
A
----
D
G
I
L
V
G
---
N
------------------------------------------------
K
R
L
M
E
----------
D
---
F
G
V
A
V
S
----------
N
-
E
V
E
L
A
--
L
E
K
L
E
--
R
E
A
K
T
A
V
I
V
A
R
N
------------------------
G
------------------------
R
-----------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
------------------------
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
-----------------
I
A
E
V
------------
L
------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
43.13
33%
1
- C4 -
-
3A1D
1
?
A:
[14-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
----
K
P
E
V
T
D
L
V
P
L
---
N
G
--------------------
D
------------------------------------
E
----------------
R
E
L
L
R
L
A
A
I
A
E
R
R
----------------
S
E
-------------------
H
P
I
A
E
A
I
V
K
K
A
L
E
H
-
G
-----
I
E
--------------------
L
--------------------
G
E
P
E
--
K
V
E
V
I
A
G
E
G
---
V
V
-
A
----
D
G
I
L
V
G
---
N
------------------------------------------------
K
R
L
M
E
----------
D
---
F
G
V
A
V
S
----------
N
-
E
V
E
L
A
--
L
E
K
L
E
--
R
E
A
K
T
A
V
I
V
A
R
N
------------------------
G
------------------------
R
-----------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
------------------------
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
-----------------
I
A
E
V
------------
L
------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
42.92
33%
-1
- C4 -
-
3A1C
1
?
A:
[14-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
----
K
P
E
V
T
D
L
V
P
L
---
N
G
--------------------
D
------------------------------------
E
----------------
R
E
L
L
R
L
A
A
I
A
E
R
R
----------------
S
E
-------------------
H
P
I
A
E
A
I
V
K
K
A
L
E
H
-
G
-----
I
E
--------------------
L
--------------------
G
E
P
E
--
K
V
E
V
I
A
G
E
G
---
V
V
-
A
----
D
G
I
L
V
G
---
N
------------------------------------------------
K
R
L
M
E
----------
D
---
F
G
V
A
V
S
----------
N
-
E
V
E
L
A
--
L
E
K
L
E
--
R
E
A
K
T
A
V
I
V
A
R
N
------------------------
G
------------------------
R
-----------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
------------------------
L
-----------------------------------------
D
------------------------------
L
-----------------------------------------------------
V
-----------------
I
A
E
V
------------
L
------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
42.61
30%
17
- C4 -
-
4UMW
-
ZNTA_SHISS
A:
[204-676]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
V
L
--
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
A
T
R
-----
L
R
-
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
---
P
F
-
A
---
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
----------
T
G
D
K
----------
V
P
A
---------
G
A
T
S
V
--
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
----
R
R
A
P
-----
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
-
V
-
T
L
VPPLL
F
-
A
A
----------
S
-
W
--
Q
E
W
I
Y
K
G
------------
L
T
-----
L
--
L
-
L
I
G
C
--
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
----
K
P
R
V
T
A
I
H
P
A
---
T
G
I
-------------------
S
------------------------------------
E
----------------
S
E
L
L
T
L
A
A
A
V
E
Q
G
----------------
A
T
-------------------
H
P
L
A
Q
A
I
V
R
--------------------------------------------------------
E
A
Q
--
V
A
E
L
A
I
P
T
A
---
E
S
Q
R
ALVG
S
G
I
E
A
Q
V
--
N
---------
G
E
R
---------
V
L
I
C
A
A
G
K
H
P
A
D
A
F
A
------------
G
L
I
N
E
------------------------------------------
L
E
--
S
A
G
Q
T
V
V
L
V
V
R
N
------------------------
D
------------------------
D
-----------------------
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
------------------------
L
------------------------------------------------------------------------
E
-----------------------------------------------------
F
-----------------
K
A
G
L
------------
L
------
P
E
D
K
V
K
A
V
-
T
K
L
N
Q
H
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------