@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VM40: (2017-11-06 )
MQSNRENQAEALLNHVNRYQAGRLTVFLGAAPGVGKTYAMLARAKELFQQGTDVVVGIVETHGRIETLKILEGLPQIARKEMQYQRHTLEEMDLDAILLRHPQIVLVDELAHRNVPNSRHERRWQDVNELLDAGIDVFTTINIQHLESLNDVVYQITGIRVNETVPDRVFDRIRDIRLIDLPVSELIERLHQGKVYVPEQANLALQGFFSISNLTALRELAMQCVAEHVDSDLKESYASKGLKSISLQNELMIAIDGQGSSEYLVRAGCRLAERNGAIWTVVNVARSLDFGQSSGNSYKKEYIEIDRAFELARQLGGRTEVLYGHRVASVLMDAAVDRGISNLVIGKSISPWWLKLFKKNLAQQLLNQENSIALTILHPEQGTKKINQLEKPSFLSLKESVFVLAVTCASIFIAHFAEVLFGIEDFSVIFIISVLIVATKTRMLAAVVAALICFLAYNFFFIAPRYTFQISAHQGVVTVVAFFAAALIAGRLASQLRQQVLSLKAANAYTTVMQDLARKLSSAVNLEEVMQTGRMTLETQLQTKVWISIRDKVISSDIELNDKEKVTAEWCLKHRQPCGRFTDTLSQSNWCFLPLLEQKNSLGIVGIYFKDELVSLNFEQKKLTESVIEYIAQAVLRTQLVDELEQAKVISETERLRSALLSSVSHDLRSPLASIIGAADTLAHFKAEMTEQDQQDLLETIHLEGERLDRYIQNLLDMTRLGHEGLTLKRDWVGVDELIGSATRRLKRYKPDTQVVVQLPEQQISLYVHPALVEQAIFNVLENAANFSPPDEPVMIRAQLSSEDEVKIEIEDRGAGIPEDERHRIFDIFYTMERGDRGKFGTGLGLTIVKAIIGAHMGTIEAFSGRQNKGTLIQIKLPLHPVKE
Atome Classification :
(20 SA)
.........10........20........30........-40........50....-....60........70........80.....-...90.-.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......-220........230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510-------.......520.......530.......540.......550.....-----..560.......570.......580........590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750..-------...--..--..760---.......770.......780.......790.---......800.-.-.....810.......820.......830....-...840.........850.......860.......870-.......880..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQS
N
R
E
N
Q
A
E
A
L
L
N
H
V
N
R
YQAG
R
L
T
V
F
L
GAAPGV
G
K
T
Y
A
-
M
L
A
R
A
K
E
L
F
QQGT
D
V
V
-
V
G
I
VETHGR
I
E
T
L
K
I
L
EG
L
P
Q
I
A
R
K
E
M
Q
Y
Q
R
-
H
T
L
E
E
M-
D
L
D
A
I
L
LRHP
Q
I
V
L
V
D
E
L
AHRNVPN
S
R
H
E
R
R
W
Q
D
V
N
E
L
L
D
AGI
D
V
F
T
T
I
N
I
Q
H
L
E
S
L
N
D
V
V
Y
Q
I
TG
I
R
VNETV
P
D
R
V
F
D
R
I
RD
I
R
L
IDL
P
V
S
E
L
I
E
R
L
HQG
K
V
YVPEQA
N
L
A
L
Q
G
F
F
S
I
S
N
L
T
A
L
R
E
-
L
-
A
M
Q
C
V
A
E
H
V
D
S
D
L
K
E
S
Y
A
SKG
L
K
SISLQN
E
L
M
I
A
IDGQGS
S
E
Y
L
V
R
AGCRLAERNG
A
I
W
T
V
V
N
V
A
R
S
LDFGQSSGN
S
Y
K
K
E
Y
I
E
I
D
R
A
F
E
L
A
R
Q
LGGR
T
E
V
L
Y
G
H
R
V
A
S
V
L
M
D
A
A
V
DRGI
S
N
LVIGKSI
S
P
W
W
L
K
L
F
K
K
N
L
A
Q
Q
L
LNQEN
S
I
A
L
T
I
LHPEQG
T
K
K
I
N
QLEKP
S
F
L
S
L
K
E
S
V
F
V
L
A
V
T
C
A
S
I
F
I
A
H
F
A
E
V
L
F
G
IE
D
F
S
V
I
F
I
I
S
V
L
I
V
AT
K
T
R
M
L
A
A
V
V
A
A
L
I
C
F
L
A
Y
N
F
F
F
IA
P
R
Y
T
F
Q
I
SAHQ
G
V
V
T
V
V
A
F
F
A
A
A
L
I
A
G
R
L
A
S
Q
L
R
Q
Q
V
L
S
L
KA
A
N
A
Y
T
T
V
-------
M
Q
D
L
A
R
K
L
S
SAV
N
L
E
E
V
M
Q
TG
R
M
T
L
E
T
Q
L
Q
T
K
V
W
I
S
I
R
D
K
VISSD-----IELND
K
E
K
V
T
A
E
W
C
L
K
HRQPC
G
R
-
F
T
D
TLSQSN
W
C
F
L
P
L
L
EQKNSL
G
I
V
G
I
Y
F
KD
E
L
V
SLN
F
E
Q
K
K
L
T
E
S
V
I
E
Y
I
A
Q
A
V
L
R
T
Q
L
V
D
E
L
E
Q
A
K
V
I
S
E
T
E
R
L
R
S
A
L
L
S
S
V
S
H
D
L
R
S
P
L
A
S
I
I
G
A
A
D
T
L
A
H
F
K
A
E
M
T
E
Q
D
Q
Q
D
L
L
E
T
I
HL
E
G
E
R
L
D
R
Y
I
Q
N
L
L
D
M
T
R
LGHEG
L
T
L
K
R
D
WV
G
V
D
E
L
I
G
S
A
T
R
R
L
K
RYK--PD-------
T
Q
V
--
V
V
--QL
P
E
Q
---
Q
I
S
L
Y
V
H
P
A
L
V
E
Q
A
I
F
N
V
L
E
N
AANFSPPDE
P
---
V
M
I
R
A
QLSSE-
D
-
E
V
K
I
E
I
EDRGAGIP
E
D
ER
H
R
I
F
D
I
F
Y
T
MERGD-RGKF--GT
G
L
G
L
T
I
V
K
A
I
I
G
A
HMGT
I
E
AFSGRQNKG
T
L
-
I
Q
I
KLPLHPVKE
56
HHSearch
85.19
62%
-133
- C2 -
-
2R8R
2
?
A:
[4-211]
--------------------
R
G
R
L
K
V
F
L
G
A
A
P
G
V
G
K
T
Y
A
-
M
L
Q
A
A
H
A
Q
L
R
Q
G
V
R
V
M
-
A
G
V
V
E
T
H
G
R
A
E
T
E
A
L
L
N
G
L
P
Q
Q
P
L
L
R
T
E
Y
R
G
-
M
T
L
E
E
M
-
D
L
D
A
L
L
K
A
A
P
S
L
V
L
V
D
E
L
A
H
T
N
A
P
G
S
R
H
T
K
R
W
Q
D
I
Q
E
L
L
A
A
G
I
D
V
Y
T
T
V
N
V
Q
H
L
E
S
L
N
D
Q
V
R
G
I
T
G
V
Q
V
R
E
T
L
P
D
W
V
L
Q
E
A
F
D
L
V
L
I
D
L
P
P
R
E
L
L
E
R
L
R
D
G
K
V
Y
V
P
E
Q
A
R
A
A
I
D
A
F
F
T
Q
T
N
L
T
A
L
R
E
-
M
-
A
M
Q
T
A
A
A
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.52
60%
-133
- C2 -
-
2R8R
2
?
A:
[5-211]
---------------------
G
R
L
K
V
F
L
G
A
A
P
G
V
G
K
T
Y
A
-
M
L
Q
A
A
H
A
Q
L
R
Q
G
V
R
V
M
-
A
G
V
V
E
T
H
G
R
A
E
T
E
A
L
L
N
G
L
P
Q
Q
P
L
L
R
T
E
Y
R
G
-
M
T
L
E
E
M
-
D
L
D
A
L
L
K
A
A
P
S
L
V
L
V
D
E
L
A
H
T
N
A
P
G
S
R
H
T
K
R
W
Q
D
I
Q
E
L
L
A
A
G
I
D
V
Y
T
T
V
N
V
Q
H
L
E
S
L
N
D
Q
V
R
G
I
T
G
V
Q
V
R
E
T
L
P
D
W
V
L
Q
E
A
F
D
L
V
L
I
D
L
P
P
R
E
L
L
E
R
L
R
D
G
K
V
Y
V
P
E
Q
A
R
A
A
I
D
A
F
F
T
Q
T
N
L
T
A
L
R
E
-
M
-
A
M
Q
T
A
A
A
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
83.45
62%
-146
* C2 *
-
2R8R
1
?
B:
[4-213]
--------------------
R
G
R
L
K
V
F
L
G
A
A
P
G
V
G
K
T
Y
A
-
M
L
Q
A
A
H
A
Q
L
R
Q
G
V
R
V
M
-
A
G
V
V
E
T
H
G
R
A
E
T
E
A
L
L
N
G
L
P
Q
Q
P
L
L
R
T
E
Y
R
G
-
M
T
L
E
E
M
-
D
L
D
A
L
L
K
A
A
P
S
L
V
L
V
D
E
L
A
H
T
N
A
P
G
S
R
H
T
K
R
W
Q
D
I
Q
E
L
L
A
A
G
I
D
V
Y
T
T
V
N
V
Q
H
L
E
S
L
N
D
Q
V
R
G
I
T
G
V
Q
V
R
E
T
L
P
D
W
V
L
Q
E
A
F
D
L
V
L
I
D
L
P
P
R
E
L
L
E
R
L
R
D
G
K
V
Y
V
-----
A
A
I
D
A
F
F
T
Q
T
N
L
T
A
L
R
E
-
M
-
A
M
Q
T
A
A
A
Q
V
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
74.28
26%
-101
- C1 -
-
4KP4
-
ENVZ_ECOLI
B:
[9-225]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
D
R
T
L
L
M
A
G
V
S
H
D
L
R
T
P
L
T
R
I
R
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
L
A
E
S
I
N
K
D
I
E
E
C
N
A
I
I
E
Q
F
I
D
Y
L
R
T
G
Q
---
E
M
P
M
E
M
A
D
L
N
A
V
L
G
E
V
I
A
A
E
S
G
Y
----
E
-------
R
E
I
--
E
T
--
A
L
Y
P
G
---
S
I
E
V
K
M
H
P
L
S
I
K
R
A
V
A
N
M
V
V
N
A
A
R
Y
G
N
--
G
W
---
I
K
V
S
S
G
T
-
E
P
-
N
-
R
A
W
F
Q
V
E
D
D
G
P
G
I
A
P
E
Q
R
K
H
L
F
Q
P
F
V
R
G
D
S
A
--
R
T
I
S
--
G
T
G
L
G
L
A
I
V
Q
R
I
V
D
N
H
N
G
M
L
E
L
G
T
-
S
E
R
G
G
L
S
-
I
R
A
W
L
P
V
P
----
43
Fugue
72.02
23%
-
- C1 -
-
4I5S
-
?
A:
[37-432]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
KVEDNS
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
-
T
D
G
V
L
A
T
D
RSGKI
T
V
I
N
--
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
D
D
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
Y
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
-------
E
S
G
F
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
--
G
A
L
T
E
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
S
-----
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
SQ
Q
S
-------
T
E
I
--
I
R
--
D
Y
P
D
K
---
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
K
---
V
T
I
T
M
Q
T
T
-
D
-
T
-
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
---------
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
-
E
G
E
G
S
T
-
F
T
I
V
L
P
------
3
PsiBlast_PDB
69.20
31%
-29
- C1 -
-
4JAU
1
?
A:
[9-229]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
E
R
L
K
R
I
---
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
--
S
S
-------
H
N
V
--
N
V
--
L
F
E
S
N
VPC
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
--
K
Y
V
K
V
I
L
D
E
K
-
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
-----------
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
-------------------------
59
HHSearch
66.41
26%
-94
- C1 -
-
4KP4
2
ENVZ_ECOLI
A:
[9-227]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
D
R
T
L
L
M
A
G
V
S
H
D
L
R
T
P
L
T
R
I
R
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
L
A
E
S
I
N
K
D
I
E
E
C
N
A
I
I
E
Q
F
I
D
Y
L
R
T
G
Q
---
E
M
P
M
E
M
A
D
L
N
A
V
L
G
E
V
I
A
A
E
S
G
Y
----
E
-------
R
E
I
--
E
T
--
A
L
Y
P
G
---
S
I
E
V
K
M
H
P
L
S
I
K
R
A
V
A
N
M
V
V
N
A
A
R
Y
G
N
--
G
W
---
I
K
V
S
S
G
T
-
E
P
-
N
-
R
A
W
F
Q
V
E
D
D
G
P
G
I
A
P
E
Q
R
K
H
L
F
Q
P
F
V
R
G
D
S
A
--
R
T
I
S
--
G
T
G
L
G
L
A
I
V
Q
R
I
V
D
N
H
N
G
M
L
E
L
G
T
-
S
E
R
G
G
L
S
-
I
R
A
W
L
P
V
P
V
T
--
4
PsiBlast_PDB
66.19
31%
-30
- C1 -
-
2C2A
1
?
A:
[9-229]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
E
R
L
K
R
I
---
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
--
S
S
-------
H
N
V
--
N
V
--
L
F
E
S
N
VPC
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
--
K
Y
V
K
V
I
L
D
E
K
-
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
-----------
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
-------------------------
6
PsiBlast_PDB
65.99
31%
-11
- C1 -
-
4JAV
1
?
A:
[9-229]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
E
R
L
K
R
I
---
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
--
S
S
-------
H
N
V
--
N
V
--
L
F
E
S
N
VPC
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
--
K
Y
V
K
V
I
L
D
E
K
-
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
-
T
Y
E
V
P-
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
-------------------------
21
PsiBlast_CBE
65.97
31%
-10
- C1 -
-
4JAV
1
?
B:
[9-229]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
E
R
L
K
R
I
---
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
--
S
S
-------
H
N
V
--
N
V
--
L
F
E
S
N
VPC
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
--
K
Y
V
K
V
I
L
D
E
K
-
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
-
T
Y
E
V
P-
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
-------------------------
5
PsiBlast_PDB
64.89
31%
2
- C1 -
-
3DGE
2
?
A:
[14-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
---
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
--
S
S
-------
H
N
V
--
N
V
--
L
F
E
S
N
VPC
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D--
K
Y
V
K
V
I
L
D
E
K
-
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
-
T
Y
E
V
P-
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
-------------------------
47
HHSearch
64.17
26%
0
- C1 -
-
5C93
1
?
A:
[11-241]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
--
K
K
DDNPA
K
Y
Y
T
I
--
K
R
--
E
F
T
K
R
---
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
V
---
V
T
C
R
L
L
E
-
T
H
-
N
-
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
----
Q
G
--
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
-
V
E
G
K
G
S
T
-
F
Y
I
S
L
P
Y
E
----
53
HHSearch
63.41
30%
20
- C1 -
-
4JAV
1
?
A:
[17-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
--
S
S
-------
H
N
V
--
N
V
L
F
E
S
N
V
P
C--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
K
V
I
L
D
E
-
K
D
-
G
-
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
--
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
-
E
V
G
K
G
S
R
-
F
F
V
W
I
P
K
D
----
22
PsiBlast_CBE
63.23
31%
5
- C1 -
-
3DGE
1
?
B:
[14-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
---
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
--
S
S
-------
H
N
V
--
N
V
--
L
F
E
S
N
VPC
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D--
K
Y
V
K
V
I
L
D
E
K
-
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
-
T
Y
E
V
P-
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
-------------------------
15
PsiBlast_PDB
63.18
29%
-29
- C1 -
-
4KP4
2
ENVZ_ECOLI
A:
[12-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
L
L
M
A
G
V
S
H
D
L
R
T
P
L
T
R
I
R
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
L
A
E
S
I
N
K
D
I
E
E
C
N
A
I
I
E
Q
F
I
D
Y
L
R
T
G
Q
E
---
M
P
M
E
M
A
D
L
N
A
V
L
G
E
V
I
A
A
E
S
G
Y
----
E
-------
R
E
I
--
E
T
--
A
L
Y
P
G
---
S
I
E
V
K
M
H
P
L
S
I
K
R
A
V
A
N
M
V
V
N
A
A
R
Y
G
N
G
-------
W
I
K
V
S
S
G
T
E
P
N
-
R
A
W
F
Q
V
E
D
D
G
P
G
I
A
P
E
Q
R
K
H
L
F
Q
P
F
V
---
R
G
D
-
S
A
R
T
I
S
G
T
G
L
G
L
A
I
V
Q
R
I
V
D
N
H
N
G
M
L
E
L
--
G
T
S
E
R
G
G
L
S
I
R
A
W
L
P
V
-
P
V
--
52
HHSearch
63.14
26%
8
- C1 -
-
4U7O
1
?
A:
[33-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
--
K
K
DDNPA
K
Y
Y
T
I
--
K
R
--
E
F
T
K
R
---
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
V
---
V
T
C
R
L
L
E
-
T
H
-
N
-
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
--
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
-
V
E
G
K
G
S
T
-
F
Y
I
S
L
P
Y
E
----
2
PsiBlast_PDB
62.55
31%
-20
- C1 -
-
4JAS
1
?
A:
[13-229]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
I
---
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
--
S
S
-------
H
N
V
--
N
V
--
L
F
E
S
N
VPC
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
--
K
Y
V
K
V
I
L
D
E
K
-
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
-
T
Y
E
V
P-
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
-------------------------
51
HHSearch
62.08
30%
23
- C1 -
-
2C2A
1
?
A:
[17-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
--
S
S
-------
H
N
V
N
V
L
F
--
E
S
N
V
P
C--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
V
K
V
I
L
D
E
-
K
D
-
G
-
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
-----------
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
-
E
V
G
K
G
S
R
-
F
F
V
W
I
P
K
D
R
---
37
Fugue
61.01
58%
-16
- C2 -
-
2R8R
2
?
A:
[3-211]
-------------------
A
R
G
R
L
K
V
F
L
G
A
A
P
G
V
G
K
T
Y
A
M
L
Q
A
A
H
A
Q
L
R
Q
G
--
V
R
V
M
A
G
V
V
E
T
H
G
R
A
E
T
E
A
L
L
N
G
L
P
Q
Q
P
L
L
R
T
E
Y
R
G
M
T
--
L
E
E
M
D
L
D
A
L
L
K
A
A
P
S
L
V
L
V
D
E
L
A
H
T
N
A
P
G
S
R
H
T
K
R
W
Q
D
I
Q
E
L
L
A
A
G
I
D
V
Y
T
T
V
N
V
Q
H
L
E
S
L
N
D
Q
V
R
G
I
T
G
V
Q
V
R
E
T
L
P
D
W
V
L
Q
E
A
F
D
L
V
L
I
D
L
P
P
R
E
L
L
E
R
L
R
D
G
K
V
Y
V
P
E
Q
A
R
A
A
I
D
A
F
F
T
Q
T
N
L
T
A
L
R
E
M
A
M
Q
T
A
A
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
59.48
29%
-
- C1 -
-
4I5S
-
?
B:
[208-434]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
A
L
--
T
E
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
I
D
N
Q
T
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
--
S
Q
Q-------
E
I
--
I
R
--
D
Y
P
D
K
---
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
K
---
V
T
I
T
M
Q
T
-
T
D
-
T
-
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
--------
T
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
-
E
E
G
E
G
S
T
-
F
T
I
V
L
P
Y
E
----