@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VM81: (2017-11-06 )
MAFKNIADQTNGFYIPCVSLFGPGCAKEIGTKAQNLGAKKALIVTDEGLFKFGVADLIASYLTEAGVASHIFPGAEPNPTDINVHNGVNAYNENGCDFIVSLGGGSSHDCAKGIGLVTAGGGHIRDYEGIDKSKVPMTPLIAVNTTAGTASEMTRFCIITNTDTHVKMAIVDWRCTPLIAIDDPKLMIAKPAGLTAATGMDALTHAVEAYVSTAANPITDACAEKAITMISQWLQPAVANGENIEARDAMSYAQYLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAILLPHVCEFNLIACPDRYAKIAELMGVNTHGLTVTEAAYAAIDAIRKLSSSIGIPSGLTELGVKTEDLAVMAENAQKDACMLTNPRKANHAQVVEIFKAAL
Atome Classification :
(20 SA)
.........10........20........30........40.....---...-50--........60........70........80........90........100.......110.......120-........130--........140.......150.......160.......170.......180.......190.......200.......210....-...220.......230.......240.......250.......260......---.270.......280.......290.......300.......310.......320.......330.......340.......350.......360.....-..370........380.......390
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
A
F
K
N
IADQTN
G
F
Y
I
P
C
V
S
LFGP
G
C
A
K
E
I
G
T
K
A
QNLGA
K
K
A
L
I
V
TD---E
G
L
-
F
K--F
G
V
A
D
L
I
A
S
Y
L
T
EAG
V
A
S
HIFPGAEPNPT
D
I
N
VHNGVNAYNENG
C
D
F
I
V
SLGGGSS
H
D
C
AKG
I
G
L
V
TAGG--GHIRDYEGID---KSKVPM
T
P
L
I
A
V
NTTAG
T
A
S
E
M
T
R
F
C
I
I
TNTDT
H
V
K
M
A
I
V
DWRC
T
P
L
I
A
IDDP
K
L
M
I
AKPAGLTAA
T
G
M
D
A
L
T
H
A
V
E
A
Y
V
S
TAAN-P
I
T
D
A
C
A
E
K
A
I
T
M
I
S
Q
W
L
Q
P
A
VANGENI
E
A
R
D
A
M
S
Y
A
Q
Y
L
A
G
MAFNNA
S
L
G
Y
---
V
H
A
M
A
H
QLGGFYNL
P
H
G
V
C
N
A
I
L
LPHVCEF
N
L
I
AC
P
D
R
Y
A
K
I
A
E
L
MGVNTHGL
T
V
T
E
A
A
Y
A
A
I
D
A
I
R
K
L
S
S
SIGIPS
G
L
T
ELGVK
T
E
D
L
A
V
M
A
ENAQK
D
-
A
C
ML-TNPRKA
N
H
A
Q
V
V
E
I
F
K
A
AL
40
PsiBlast_CBE
97.12
56%
-105
- C4 -
-
3OX4
1
ADH2_ZYMMO
D:
[6-383]
------------
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
---
A
F
M
-
N
K
--
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
--
G
E
V
K
D
Y
E
G
I
D
---
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
-
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
---
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
-
A
C
A
L
-
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
42
PsiBlast_CBE
96.71
56%
-107
- C4 -
-
3OX4
1
ADH2_ZYMMO
B:
[6-383]
------------
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
---
A
F
M
-
N
K
--
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
--
G
E
V
K
D
Y
E
G
I
D
---
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
-
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
---
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
-
A
C
A
L
-
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
3
PsiBlast_PDB
96.45
56%
-106
- C4 -
-
3OX4
1
ADH2_ZYMMO
A:
[6-383]
------------
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
---
A
F
M
-
N
K
--
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
--
G
E
V
K
D
Y
E
G
I
D
---
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
-
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
---
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
-
A
C
A
L
-
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
41
PsiBlast_CBE
96.43
56%
-104
- C4 -
-
3OX4
1
ADH2_ZYMMO
C:
[6-383]
------------
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
---
A
F
M
-
N
K
--
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
--
G
E
V
K
D
Y
E
G
I
D
---
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
-
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
---
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
-
A
C
A
L
-
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
60
HHSearch
96.17
55%
-104
- C4 -
-
3BFJ
-
DHAT_KLEPN
J:
[4-387]
--------
R
M
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
G
K
K
A
L
L
V
T
D
---
K
G
L
-
R
K
--
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
--
G
D
L
Y
Q
Y
A
G
I
E
---
T
L
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
-
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
---
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
E
N
I
T
G
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
Y
M
A
E
M
A
L
K
D
-
G
-
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
2
PsiBlast_PDB
96.14
56%
-110
- C4 -
-
3OWO
-
ADH2_ZYMMO
A:
[6-383]
------------
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
---
A
F
M
-
N
K
--
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
--
G
E
V
K
D
Y
E
G
I
D
---
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
-
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
---
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
-
A
C
A
L
-
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
59
HHSearch
95.21
55%
-99
- C4 -
-
3OX4
1
ADH2_ZYMMO
B:
[2-383]
--------
A
S
S
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
---
A
F
M
-
N
K
--
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
--
G
E
V
K
D
Y
E
G
I
D
---
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
-
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
---
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
-
A
-
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
1
PsiBlast_PDB
86.34
55%
-36
- C4 -
-
3BFJ
-
DHAT_KLEPN
A:
[8-387]
------------
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
G
K
K
A
L
L
V
T
D
---
K
G
L
R-
K
--
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
--
G
D
L
Y
Q
Y
A
G
I
E
---
T
L
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
-
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
---
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
E
N
I
T
G
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
Y
M
A
E
M
A
L
K
D
-
G
N
A
F
-
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
4
PsiBlast_PDB
80.06
50%
-28
- C4 -
-
4FR2
-
?
A:
[16-397]
---------
A
Y
D
F
L
M
P
S
V
N
F
F
G
P
G
V
I
S
K
I
G
E
R
A
K
M
L
G
M
K
K
P
V
I
V
T
D
K
F
L
E
N
L
-
K
N
--
G
A
V
A
Q
T
L
A
S
-
L
K
K
S
G
V
D
Y
V
V
Y
N
G
V
E
P
N
P
K
I
H
N
I
K
E
V
K
T
L
Y
E
K
E
D
A
D
S
I
I
T
V
G
G
G
S
A
H
D
T
G
K
G
A
G
I
I
M
T
N
G
--
D
D
I
T
K
L
A
G
I
E
---
T
L
K
N
P
L
P
P
L
I
A
V
N
T
T
A
G
T
G
S
E
L
T
R
H
A
V
I
T
N
E
E
T
H
L
K
F
V
V
V
S
W
R
N
I
P
L
V
S
F
N
D
P
T
L
M
L
D
I
P
K
G
L
T
A
A
T
G
M
D
A
F
V
Q
A
V
E
P
Y
V
S
V
D
H
N
-
P
I
T
D
S
Q
C
I
Q
A
I
K
L
I
E
S
S
L
R
E
A
V
A
N
G
H
N
L
Q
A
R
T
K
M
V
E
A
E
M
L
A
G
M
A
F
N
N
A
N
L
G
Y
---
V
H
A
M
A
H
Q
L
G
G
Q
Y
D
A
P
H
G
V
C
C
A
L
L
L
P
Y
A
E
E
Y
N
L
I
A
D
P
E
R
F
A
E
L
A
R
I
M
G
E
N
T
D
G
L
S
T
R
D
A
A
E
L
S
I
K
A
M
K
Q
L
S
E
D
V
G
I
P
H
S
I
K
D
I
G
A
K
P
E
D
F
D
L
M
A
E
N
A
L
K
D
-
G
N
A
F
-
S
N
P
R
K
G
T
K
E
D
I
V
K
I
F
Q
E
A
-
63
HHSearch
74.83
40%
-43
- C4 -
-
5BR4
3
FUCO_ECOLI
B:
[3-383]
---------
A
N
R
M
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
---
K
T
L
-
V
Q
--
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
EF
A
D
V
R
S
L
E
G
L
S
---
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
C
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
-
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
--
D
K
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
---
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
-
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
62
HHSearch
74.79
49%
-5
- C4 -
-
4FR2
-
?
A:
[16-398]
---------
A
Y
D
F
L
M
P
S
V
N
F
F
G
P
G
V
I
S
K
I
G
E
R
A
K
M
L
G
M
K
K
P
V
I
V
T
D
---
K
F
L
-
E
N
L
K
N
G
A
V
A
Q
T
L
A
S
L
K
K
S
G
V
D
Y
V
V
Y
N
G
V
E
P
N
P
K
I
H
N
I
K
E
V
K
T
L
Y
E
K
E
D
A
D
S
I
I
T
V
G
G
G
S
A
H
D
T
G
K
G
A
G
I
I
M
T
N
G
--
D
D
I
T
K
L
A
G
I
E
---
T
L
K
N
P
L
P
P
L
I
A
V
N
T
T
A
G
T
G
S
E
L
T
R
H
A
V
I
T
N
E
E
T
H
L
K
F
V
V
V
S
W
R
N
I
P
L
V
S
F
N
D
P
T
L
M
L
D
I
P
K
G
L
T
A
A
T
G
M
D
A
F
V
Q
A
V
E
P
Y
V
S
V
D
H
N
-
P
I
T
D
S
Q
C
I
Q
A
I
K
L
I
E
S
S
L
R
E
A
V
A
N
G
H
N
L
Q
A
R
T
K
M
V
E
A
E
M
L
A
G
M
A
F
N
N
A
N
L
G
Y
---
V
H
A
M
A
H
Q
L
G
G
Q
Y
D
A
P
H
G
V
C
C
A
L
L
L
P
Y
A
E
E
Y
N
L
I
A
D
P
E
R
F
A
E
L
A
R
I
M
G
E
N
T
D
G
L
S
T
R
D
A
A
E
L
S
I
K
A
M
K
Q
L
S
E
D
V
G
I
P
H
S
I
K
D
I
G
A
K
P
E
D
F
D
L
M
A
E
N
A
L
K
D
-
G
N
A
F
-
S
N
P
R
K
G
T
K
E
D
I
V
K
I
F
Q
E
A
Y
61
HHSearch
74.13
39%
-44
- C4 -
-
1RRM
2
FUCO_ECOLI
A:
[2-383]
--------
M
A
N
R
M
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
---
K
T
L
-
V
Q
--
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
EF
A
D
V
R
S
L
E
G
L
S
---
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
-
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
--
D
K
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
---
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
-
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
8
PsiBlast_PDB
72.33
38%
-43
- C4 -
-
1RRM
2
FUCO_ECOLI
A:
[12-382]
------------------
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
---
K
T
L
-
V
Q
--
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
EF
A
D
V
R
S
L
E
G
L
S
---
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
-
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
--
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
---
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
-
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
-
5
PsiBlast_PDB
72.10
39%
-43
- C4 -
-
2BI4
1
FUCO_ECOLI
A:
[21-391]
------------------
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
---
K
T
L
-
V
Q
--
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
EF
A
D
V
R
S
L
E
G
L
S
---
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
-
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
--
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
---
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
-
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
-
48
PsiBlast_CBE
72.00
39%
-41
- C4 -
-
5BR4
3
FUCO_ECOLI
B:
[12-382]
------------------
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
---
K
T
L
-
V
Q
--
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
EF
A
D
V
R
S
L
E
G
L
S
---
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
C
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
-
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
--
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
---
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
-
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
-
7
PsiBlast_PDB
71.94
39%
-43
- C4 -
-
5BR4
3
FUCO_ECOLI
A:
[12-382]
------------------
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
---
K
T
L
-
V
Q
--
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
EF
A
D
V
R
S
L
E
G
L
S
---
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
C
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
-
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
--
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
---
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
-
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
-
46
PsiBlast_CBE
71.75
39%
-43
- C4 -
-
2BL4
1
FUCO_ECOLI
B:
[21-391]
------------------
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
---
K
T
L
-
V
Q
--
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
EF
A
D
V
R
S
L
E
G
L
S
---
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
-
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
--
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
---
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
-
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
-
47
PsiBlast_CBE
71.52
39%
-45
- C4 -
-
2BI4
1
FUCO_ECOLI
B:
[21-391]
------------------
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
---
K
T
L
-
V
Q
--
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
EF
A
D
V
R
S
L
E
G
L
S
---
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
-
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
--
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
---
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
-
V
C
T
G
-
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
-
6
PsiBlast_PDB
71.33
39%
-40
- C4 -
-
2BL4
1
FUCO_ECOLI
A:
[21-391]
------------------
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
---
K
T
L
-
V
Q
--
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
EF
A
D
V
R
S
L
E
G
L
S
---
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
-
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
--
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
---
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
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A
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-
49
Fugue
63.38
23%
-63
- C4 -
-
1OJ7
2
YQHD_ECOLI
A:
[19-408]
----
K
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