@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VM82: (2017-11-06 )
MKQETALKLLKAGENVFLTGSAGAGKTYTLNQYIHYLKARKVPVAITASTGIAATHMNGMTIHTWAGIGIKDHLTDDDLKRMKERKYLKEHLEDAQVLVIDEISMLHAKQLNLVNQVLKYFKESDEAFGGIQVIVAGDFFQLPPVGRNGEANRDKFCFMSDAWVEAKFRVCYLTEQHRQDDEILNQILNAIRAQSIQTEHLQALHQSRTHDIGETFTRLYTHNMDVDNINYQHLNEIDNEGHQFNAVLDGNEKLLETLKSSVRAPEELTLKKHAKVMFVKNNFDMGYINGSLGEVIGFEEDDENGLLPKVKLTDGTTLLVAPETWSIENEAGKVIASFQQIPLRLAWAITIHKSQGMTLEAAEINLMHTFEKGQGYVALSRLKSLTGLKLLGFNEQALELDSLAVKADRRFQKLSKEAEDNFANVDLTAQHKAFIRHCGGTLNETEISRNEKKLARGEKQNYASATLDETRALFEEGYEIEDIAHERGLTPATIINHLARLHKEQKLDISVAHPGEEVVEEVRKIYKKLKKRQNPDHFSDDGSIKLRPIVEATSPRMGYDQVRLALLFIE
Atome Classification :
(20 SA)
---.........10-----........20........30........----40.-.......50......------.-----------------------.60........70.----.......80...-.....90.....--...100....-...110.......120.......130.......140.......150------...-.----...160....-------------------....170.......180........190...--------------------....200-------------....--------------.....----210---.---------------------------------........220--....---...-..230.......240.......250.......260--........270......----.280.-----------......290.......300....------...310------......-----..320..-------------------..------...-------330-----...-.-.....340---.-.......350.......----360......------.370.......380.......390......---.400.......410.......420.......430.......440.......450.---------......---------460.......470.......480.......490.......500.......510.......520.......530.......540..--.....550.......560.......570-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MK
Q
E
T
A
L
K
L
L
K-----AGE
N
V
F
L
TGSAGAG
K
T
Y
T
L
N
Q
Y
I
H
Y
L
K
A----RKV-
P
V
A
I
TAST
G
I
A
A
T
HM------N-----------------------
G
M
T
I
H
T
W
AGIGIKD----HL
T
D
D
D
L
K
R
M
K
E
-
R
K
Y
L
K
E
H
LEDA
Q
--
V
L
V
I
D
E
I
S
M
L
-
H
A
K
Q
L
N
L
V
N
Q
V
L
K
Y
F
K
ESDEAFG
G
I
Q
V
I
V
AGDFFQLPPVGRNGEAN------R
D
K
-
F
----
C
F
MSD-
A
W
V
E
-------------------
A
K
F
R
V
C
Y
L
T
E
Q
HR
Q
D
-
D
E
I
L
N
Q
I
L
N
A
I
R
A
QS--------------------I
Q
T
E
H
---------------
L
Q
A
L
--------------
H
Q
SRT----
H
-----
D
---------------------------------
I
G
E
T
F
T
R
L
Y
----THNM---DVD-NI
N
Y
Q
H
L
N
E
IDNEG
H
Q
F
N
A
V
LDG
N
E
K
L
L
E
T
L
K
S
S
---VRA
P
E
E
L
T
L
K
KH
A
K
V
M
F
----
V
KNNF-----------D
M
G
Y
INGSLGEVIGFEEDDENGL------
L
P
K
V
K
-------LTDG
T
T
-----
L
L
V
APET-------------------WS------IEN-------E-------
A
G
K
-
V
-
I
A
S
F
Q
QI----
P
-
L
R
L
A
W
A
I
T
I
HKSQ
G
M
T
L
----
E
A
A
E
I
N
L
M
H
------
T
FEKGQG
Y
V
A
L
S
R
L
K
S
L
TG
L
K
L
LGFN
E
Q
AL---
E
L
D
S
L
A
V
K
A
D
R
R
F
Q
K
L
S
K
E
AEDNFANVD
L
T
A
Q
H
K
A
F
I
R
HCGGTL
N
E
T
E
ISR
N
E
K
K
---------
L
ARGEK---------QNYASA
T
L
D
E
T
R
A
L
F
EEGY
E
I
E
D
I
A
H
ERGL
T
P
A
T
I
I
N
H
L
A
R
L
H
KEQKL
D
I
S
VAHP
G
E
E
V
V
E
E
V
R
K
I
Y
K
K
L
K
KRQNPDHFSDDG
S
I
--
K
L
R
P
I
V
EATSPRM
G
Y
D
Q
V
R
L
A
L
L
F
IE---
1
PsiBlast_PDB
78.84
36%
-33
- C3 -
-
5FTF
1
?
A:
[23-397]
----------------------
N
V
F
V
T
G
K
A
G
S
G
K
T
-
T
F
L
K
Y
L
I
E
K
S
G
----
K
N
C
-
I
V
A
--
A
P
T
G
I
A
A
I
N
A
------
G
-----------------------
G
V
T
L
H
S
L
F
G
I
P
F
G
P
-----
I
T
P
Y
D
R
L
E
N
K
F
-
S
E
Y
K
V
E
C
L
L
K
M
E
--
L
L
I
I
D
E
I
S
M
V
-
R
P
D
I
L
D
T
I
D
R
K
L
R
W
V
Y
E
S
D
E
P
F
G
G
V
Q
V
I
M
F
G
D
L
F
Q
L
P
P
V
T
K
K
Q
E
R
E
ILSDF-
Y
D
G
-
F
----
F
F
F
N
A
L
V
F
K
R
-------------------
T
G
F
H
I
V
E
L
T
K
I
F
R
Q
T
-
E
P
E
F
I
N
V
L
N
N
I
R
N
Y
Q
--------------------
V
T
S
D
E
---------------
L
D
L
L
--------------
S
E
L
K
D
----
R
-----
K
---------------------------------
I
S
S
S
Y
D
N
E
Y
IHIC
T
H
K
A
---
D
V
E
-
K
I
N
A
D
K
L
G
E
--
Q
E
I
R
N
Y
D
I
V
I
--
K
D
K
F
P
E
---
S
S
---
I
P
C
D
L
H
L
K
L
R
V
G
A
R
V
M
S
----
L
V
N
D
S
-----------
L
K
G
Y
Y
N
G
M
L
G
I
V
T
A
L
E
D
N
-----------
V
I
T
V
R
-------
M
D
N
G
R
T
-----
I
K
F
E
R
Y
T
-------------------
W
S
N
T
Q
Y
T
L
K
D
N
-------
E
-------
C
V
K
E
E
-
I
G
S
C
T
Q
F
----
P
-
L
T
L
A
W
A
I
T
I
H
K
S
Q
G
L
T
F
----
D
K
I
I
I
H
V
S
H
------
T
F
C
P
G
Q
L
Y
V
A
L
S
R
C
R
T
L
E
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
77.31
34%
1
- C3 -
-
5FTF
1
?
A:
[8-419]
---
E
E
M
Q
K
I
M
N
L
I
Q
D----
D
E
N
N
V
F
V
T
G
K
A
G
S
G
K
T
T
F
L
K
Y
L
I
E
K
S
-------
G
K
-
N
C
I
V
A
A
P
T
G
I
A
A
I
N
A
------
G
-----------------------
G
V
T
L
H
S
L
F
G
I
P
F
G
P
----
I
T
P
Y
D
R
L
E
N
K
-
F
-
S
E
Y
K
V
E
C
L
L
K
M
E
--
L
L
I
I
D
E
I
S
M
V
-
R
P
D
I
L
D
T
I
D
R
K
L
R
W
V
Y
E
S
D
E
P
F
G
G
V
Q
V
I
M
F
G
D
L
F
Q
L
P
P
V
T
K
K
Q
E
R
E
ILSDFY
D
G
F
-
F
----
F
F
N
A
L
-
V
F
K
R
-------------------
T
G
F
H
I
V
E
L
T
K
I
F
R
Q
T
-
E
P
E
F
I
N
V
L
N
N
I
R
N
Y
Q
--------------------
V
T
S
D
E
---------------
L
D
L
L
--------------
S
E
L
K
D
R
K
I
S
S
-----
S
---------------------------------
Y
D
N
E
Y
I
H
I
C
----
T
H
K
A
---
D
V
E
-
K
I
N
A
D
K
L
G
E
Q
E
I
R
N
Y
D
I
V
I
K
D
K
-------
F
P
E
S
S
---
I
P
C
D
L
H
L
K
L
R
V
G
A
R
V
M
S
----
L
V
N
D
S
-----------
L
K
G
Y
Y
N
G
M
L
G
I
V
T
A
L
E
D
N
-----------
V
I
T
V
R
-------
M
D
N
G
R
T
-----
I
K
F
E
R
Y
T
-------------------
W
S
------
N
T
Q
-------
Y
T
L
K
DN
E
C
V
K
E
-
E
-
I
G
S
C
T
Q
F
----
P
-
L
T
L
A
W
A
I
T
I
H
K
S
Q
G
L
T
F
----
D
K
I
I
I
H
V
S
H
------
T
F
C
P
G
Q
L
Y
V
A
L
S
R
C
R
T
--
L
E
G
I
V
S
D
A
F
I
T
K
QMI
I
P
E
Y
A
L
I
D
F
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.17
36%
-26
- C3 -
-
5FTD
-
?
A:
[23-397]
----------------------
N
V
F
V
T
G
K
A
G
S
G
K
T
-
T
F
L
K
Y
L
I
E
K
S
G
----
K
N
C
-
I
V
A
--
A
P
T
G
I
A
A
I
N
A
------
G
-----------------------
G
V
T
L
H
S
L
F
G
I
P
F
G
P
-----
I
T
P
Y
D
R
L
E
N
K
F
-
S
E
Y
K
V
E
L
L
L
K
M
E
--
L
L
I
I
D
E
I
S
M
V
-
R
P
D
I
L
D
T
I
D
R
K
L
R
W
V
Y
E
S
D
E
P
F
G
G
V
Q
V
I
M
F
G
D
L
F
Q
L
P
P
V
T
K
K
Q
E
R
E
I
L
SDF-
Y
D
G
-
F
----
F
F
F
N
A
L
V
F
K
R
-------------------
T
G
F
H
I
V
E
L
T
K
I
F
R
Q
T
-
E
P
E
F
I
N
V
L
N
N
I
R
N
Y
Q
--------------------
V
T
S
D
E
---------------
L
D
L
L
--------------
S
E
L
K
D
----
R
-----
K
---------------------------------
I
S
S
S
Y
D
N
E
Y
I
H
I
C
T
H
K
A
---
D
V
E
-
K
I
N
A
D
K
L
G
E
--
Q
E
I
R
N
Y
D
I
V
I
--
K
D
K
F
P
E
---
S
S
---
I
P
C
D
L
H
L
K
L
R
V
G
A
R
V
M
S
----
L
V
N
D
S
-----------
L
K
G
Y
Y
N
G
M
L
G
I
V
T
A
L
E
D
N
-----------
V
I
T
V
R
-------
M
D
N
G
R
T
-----
I
K
F
E
R
Y
T
-------------------
W
S
N
T
Q
Y
T
L
K
D
N
-------
E
-------
I
V
K
E
E
-
I
G
S
C
T
Q
F
----
P
-
L
T
L
A
W
A
I
T
I
H
K
S
Q
G
L
T
F
----
D
K
I
I
I
H
V
S
H
------
T
F
C
P
G
Q
L
Y
V
A
L
S
R
C
R
T
L
E
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
76.30
35%
1
- C3 -
-
5FTB
1
?
A:
[8-400]
---
E
E
M
Q
K
I
M
N
L
I
Q
D----
D
E
N
N
V
F
V
T
G
K
A
G
S
G
K
T
T
F
L
K
Y
L
I
E
K
S
-------
G
K
-
N
C
I
V
A
A
P
T
G
I
A
A
I
N
A
------
G
-----------------------
G
V
T
L
H
S
L
F
G
I
P
F
G
P
----
I
T
P
Y
D
R
L
E
N
-
K
F
-
S
E
Y
K
V
E
L
L
L
K
M
E
--
L
L
I
I
D
E
I
S
M
V
-
R
P
D
I
L
D
T
I
D
R
K
L
R
W
V
Y
E
S
D
E
P
F
G
G
V
Q
V
I
M
F
G
D
L
F
Q
L
P
P
V
T
K
K
Q
E
R
E
I
L
SDFY
D
G
F
-
F
----
F
F
N
A
L
-
V
F
K
R
-------------------
T
G
F
H
I
V
E
L
T
K
I
F
R
Q
T
-
E
P
E
F
I
N
V
L
N
N
I
R
N
Y
Q
--------------------
V
T
S
D
E
---------------
L
D
L
L
--------------
S
E
L
K
D
R
K
I
S
S
-----
S
---------------------------------
Y
D
N
E
Y
I
H
I
C
----
T
H
K
A
---
D
V
E
-
K
I
N
A
D
K
L
G
E
Q
E
I
R
N
Y
D
I
V
I
K
D
K
-------
F
P
E
S
S
---
I
P
C
D
L
H
L
K
L
R
V
G
A
R
V
M
S
----
L
V
N
D
S
-----------
L
K
G
Y
Y
N
G
M
L
G
I
V
T
A
L
E
D
N
-----------
V
I
T
V
R
-------
M
D
N
G
R
T
-----
I
K
F
E
R
Y
T
-------------------
W
S
------
N
T
Q
Y
T
L
KDN
E
I
-------
V
K
E
-
E
-
I
G
S
C
T
Q
F
----
P
-
L
T
L
A
W
A
I
T
I
H
K
S
Q
G
L
T
F
----
D
K
I
I
I
H
V
S
H
------
T
F
C
P
G
Q
L
Y
V
A
L
S
R
C
R
T
--
L
E
G
I
V
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.01
36%
-26
- C3 -
-
5FHF
1
?
A:
[23-397]
----------------------
N
V
F
V
T
G
K
A
G
S
G
K
T
-
T
F
L
K
Y
L
I
E
K
S
G
----
K
N
C
-
I
V
A
--
A
P
T
G
I
A
A
I
N
A
------
G
-----------------------
G
V
T
L
H
S
L
F
G
I
P
F
G
P
-----
I
T
P
Y
D
R
L
E
N
K
F
-
S
E
Y
K
V
E
L
L
L
K
M
E
--
L
L
I
I
D
E
I
S
M
V
-
R
P
D
I
L
D
T
I
D
R
K
L
R
W
V
Y
E
S
D
E
P
F
G
G
V
Q
V
V
M
F
G
D
L
F
Q
L
P
P
V
T
K
K
Q
E
R
E
I
L
SDF-
Y
D
G
-
F
----
F
F
F
N
A
L
V
F
K
R
-------------------
T
G
F
H
I
V
E
L
T
K
I
F
R
Q
T
-
E
P
E
F
I
N
V
L
N
N
I
R
N
Y
Q
--------------------
V
T
S
D
E
---------------
L
D
L
L
--------------
S
E
L
K
D
----
R
-----
K
---------------------------------
I
S
S
S
Y
D
N
E
Y
I
H
I
C
T
H
K
A
---
D
V
E
-
K
I
N
A
D
K
L
G
E
--
Q
E
I
R
N
Y
D
I
V
I
--
K
D
K
F
P
E
---
S
S
---
I
P
C
D
L
H
L
K
L
R
V
G
A
R
V
M
S
----
L
V
N
D
S
-----------
L
K
G
Y
Y
N
G
M
L
G
I
V
T
A
L
E
D
N
-----------
V
I
T
V
R
-------
M
D
N
G
R
T
-----
I
K
F
E
R
Y
T
-------------------
W
S
N
T
Q
Y
T
L
K
D
N
-------
E
-------
I
V
K
-
E
E
I
G
S
C
T
Q
F
----
P
-
L
T
L
A
W
A
I
T
I
H
K
S
Q
G
L
T
F
----
D
K
I
I
I
H
V
S
H
------
T
F
C
P
G
Q
L
Y
V
A
L
S
R
C
R
T
L
E
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.57
36%
-24
- C3 -
-
5FTC
1
?
A:
[23-397]
----------------------
N
V
F
V
T
G
K
A
G
S
G
K
T
-
T
F
L
K
Y
L
I
E
K
S
G
----
K
N
C
-
I
V
A
--
A
P
T
G
I
A
A
I
N
A
------
G
-----------------------
G
V
T
L
H
S
L
F
G
I
P
F
G
P
-----
I
T
P
Y
D
R
L
E
N
K
F
-
S
E
Y
K
V
E
L
L
L
K
M
E
--
L
L
I
I
D
E
I
S
M
V
-
R
P
D
I
L
D
T
I
D
R
K
L
R
W
V
Y
E
S
D
E
P
F
G
G
V
Q
V
I
M
F
G
D
L
F
Q
L
P
P
V
T
K
K
Q
E
R
E
I
L
SDF-
Y
D
G
-
F
----
F
F
F
N
A
L
V
F
K
R
-------------------
T
G
F
H
I
V
E
L
T
K
I
F
R
Q
T
-
E
P
E
F
I
N
V
L
N
N
I
R
N
Y
Q
--------------------
V
T
S
D
E
---------------
L
D
L
L
--------------
S
E
L
K
D
----
R
-----
K
---------------------------------
I
S
S
S
Y
D
N
E
Y
I
H
I
C
T
H
K
A
---
D
V
E
-
K
I
N
A
D
K
L
G
E
--
Q
E
I
R
N
Y
D
I
V
I
--
K
D
K
F
P
E
---
S
S
---
I
P
C
D
L
H
L
K
L
R
V
G
A
R
V
M
S
----
L
V
N
D
S
-----------
L
K
G
Y
Y
N
G
M
L
G
I
V
T
A
L
E
D
N
-----------
V
I
T
V
R
-------
M
D
N
G
R
T
-----
I
K
F
E
R
Y
T
-------------------
W
S
N
T
Q
Y
T
L
K
D
N
-------
E
-------
I
V
K
E
E
-
I
G
S
C
T
Q
F
----
P
-
L
T
L
A
W
A
I
T
I
H
K
S
Q
G
L
T
F
----
D
K
I
I
I
H
V
S
H
------
T
F
C
P
G
Q
L
Y
V
A
L
S
R
C
R
T
L
E
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.41
36%
-15
- C3 -
-
5FTB
1
?
A:
[23-397]
----------------------
N
V
F
V
T
G
K
A
G
S
G
K
T
-
T
F
L
K
Y
L
I
E
K
S
G
----
K
N
C
-
I
V
A
--
A
P
T
G
I
A
A
I
N
A
------
G
-----------------------
G
V
T
L
H
S
L
F
G
I
P
F
G
P
-----
I
T
P
Y
D
R
L
E
N
K
F
-
S
E
Y
K
V
E
L
L
L
K
M
E
--
L
L
I
I
D
E
I
S
M
V
-
R
P
D
I
L
D
T
I
D
R
K
L
R
W
V
Y
E
S
D
E
P
F
G
G
V
Q
V
I
M
F
G
D
L
F
Q
L
P
P
V
T
K
K
Q
E
R
E
I
L
SDF-
Y
D
G
-
F
----
F
F
F
N
A
L
V
F
K
R
-------------------
T
G
F
H
I
V
E
L
T
K
I
F
R
Q
T
-
E
P
E
F
I
N
V
L
N
N
I
R
N
Y
Q
--------------------
V
T
S
D
E
---------------
L
D
L
L
--------------
S
E
L
K
D
----
R
-----
K
---------------------------------
I
S
S
S
Y
D
N
E
Y
I
H
I
C
T
H
K
A
---
D
V
E
-
K
I
N
A
D
K
L
G
E
--
Q
E
I
R
N
Y
D
I
V
I
--
K
D
K
F
P
E
---
S
S
---
I
P
C
D
L
H
L
K
L
R
V
G
A
R
V
M
S
----
L
V
N
D
S
-----------
L
K
G
Y
Y
N
G
M
L
G
I
V
T
A
L
E
D
N
-----------
V
I
T
V
R
-------
M
D
N
G
R
T
-----
I
K
F
E
R
Y
T
-------------------
W
S
N
T
Q
Y
T
L
K
D
N
-------
E
-------
I
V
K
E
E
-
I
G
S
C
T
Q
F
----
P
-
L
T
L
A
W
A
I
T
I
H
K
S
Q
G
L
T
F
----
D
K
I
I
I
H
V
S
H
------
T
F
C
P
G
Q
L
Y
V
A
L
S
R
C
R
T
L
E
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.65
36%
-25
- C3 -
-
5FHE
2
?
A:
[23-397]
----------------------
N
V
F
V
T
G
K
A
G
S
G
K
T
-
T
F
L
K
Y
L
I
E
K
S
G
----
K
N
C
-
I
V
A
--
A
P
T
G
I
A
A
I
N
A
------
G
-----------------------
G
V
T
L
H
S
L
F
G
I
P
F
G
P
-----
I
T
P
Y
D
R
L
E
N
K
F
-
S
E
Y
K
V
E
L
L
L
K
M
E
--
L
L
I
I
D
E
I
S
M
V
-
R
P
D
I
L
D
T
I
D
R
K
L
R
W
V
Y
E
S
D
E
P
F
G
G
V
Q
V
V
M
F
G
D
L
F
Q
L
P
P
V
T
K
K
Q
E
R
E
I
L
S
D
F
-
Y
D
G
-
F
----
F
F
F
N
A
L
V
F
K
R
-------------------
T
G
F
H
I
V
E
L
T
K
I
F
R
Q
T
-
E
P
E
F
I
N
V
L
N
N
I
R
N
Y
Q
--------------------
V
T
S
D
E
---------------
L
D
L
L
--------------
S
E
L
K
D
----
R
-----
K
---------------------------------
I
S
S
S
--
N
E
Y
I
H
I
C
T
H
K
A
---
D
V
E
-
K
I
N
A
D
K
L
G
E
--
Q
E
I
R
N
Y
D
I
V
I
--
K
D
K
F
P
E
---
S
S
---
I
P
C
D
L
H
L
K
L
R
V
G
A
R
V
M
S
----
L
V
N
D
S
-----------
L
K
G
Y
Y
N
G
M
L
G
I
V
T
A
L
E
D
N
-----------
V
I
T
V
R
-------
M
D
N
G
R
T
-----
I
K
F
E
R
Y
T
-------------------
W
S
N
T
Q
Y
T
L
K
D
N
-------
E
-------
I
V
K
-
E
E
I
G
S
C
T
Q
F
----
P
-
L
T
L
A
W
A
I
T
I
H
K
S
Q
G
L
T
F
----
D
K
I
I
I
H
V
S
H
------
T
F
C
P
G
Q
L
Y
V
A
L
S
R
C
R
T
L
E
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.35
36%
-21
- C- -
-
5FHG
-
?
A:
[23-397]
----------------------
N
V
F
V
T
G
K
A
G
S
G
K
T
-
T
F
L
K
Y
L
I
E
K
------
K
N
C
-
I
V
A
--
A
P
T
G
I
A
A
I
N
A
------
G
-----------------------
G
V
T
L
H
S
L
F
G
I
P
F
G
P
-----
I
T
P
Y
D
R
L
E
--
F
-
S
E
Y
K
V
E
L
L
L
K
M
E
--
L
L
I
I
D
E
I
S
M
V
-
R
P
D
I
L
D
T
I
D
R
K
L
R
W
V
Y
E
S
D
E
P
F
G
G
V
Q
V
V
M
F
G
D
L
F
Q
L
P
P
V
T
K
K
Q
E
R
E
I
L
SDF-
Y
D
G
-
F
----
F
F
F
N
A
L
V
F
K
R
-------------------
T
G
F
H
I
V
E
L
T
K
I
F
R
Q
T
-
E
P
E
F
I
N
V
L
N
N
I
R
N
Y
Q
--------------------
V
T
S
D
E
---------------
L
D
L
L
--------------
S
E
L
K
D
----
R
-----
K
---------------------------------
I
S
S
S
Y
D
N
E
Y
I
H
I
C
T
H
K
A
---
D
V
E
-
K
I
N
A
D
K
L
G
E
--
Q
E
I
R
N
Y
D
I
V
I
--
K
D
K
F
P
E
---
S
S
---
I
P
C
D
L
H
L
K
L
R
V
G
A
R
V
M
S
----
L
V
N
D
S
-----------
L
K
G
Y
Y
N
G
M
L
G
I
V
T
A
L
E
D
N
-----------
V
I
T
V
R
-------
M
D
N
G
R
T
-----
I
K
F
E
R
Y
T
-------------------
W
S
N
T
Q
Y
T
L
K
D
N
-------
E
-------
I
V
K
-
E
E
I
G
S
C
T
Q
F
----
P
-
L
T
L
A
W
A
I
T
I
H
K
S
Q
G
L
T
F
----
D
K
I
I
I
H
V
S
H
------
T
F
C
P
G
Q
L
Y
V
A
L
S
R
C
R
T
L
E
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.02
36%
-19
- C3 -
-
5FTE
3
?
A:
[23-397]
----------------------
N
V
F
V
T
G
K
A
G
S
G
K
T
-
T
F
L
K
Y
L
I
E
K
S
G
----
K
N
C
-
I
V
A
--
A
P
T
G
I
A
A
I
N
A
------
G
-----------------------
G
V
T
L
H
S
L
F
G
I
P
F
G
P
-----
I
T
P
Y
D
R
L
E
N
K
F
-
S
E
Y
K
V
E
L
L
L
K
M
E
--
L
L
I
I
D
E
I
S
M
V
-
R
P
D
I
L
D
T
I
D
R
K
L
R
W
V
Y
E
S
D
E
P
F
G
G
V
Q
V
I
M
F
G
D
L
F
Q
L
P
P
V
T
K
K
Q
E
R
E
I
L
S
D
F-
Y
D
G
-
F
----
F
F
F
N
A
L
V
F
K
R
-------------------
T
G
F
H
I
V
E
L
T
K
I
F
R
Q
T
-
E
P
E
F
I
N
V
L
N
N
I
R
N
Y
Q
--------------------
V
T
S
D
E
---------------
L
D
L
L
--------------
S
E
L
K
D
----
R
-----
K
---------------------------------
I
S
S
S
Y
D
N
E
Y
I
H
I
C
T
H
K
A
---
D
V
E
-
K
I
N
A
D
K
L
G
E
--
Q
E
I
R
N
Y
D
I
V
I
--
K
D
K
F
P
E
---
S
S
---
I
P
C
D
L
H
L
K
L
R
V
G
A
R
V
M
S
----
L
V
N
D
S
-----------
L
K
G
Y
Y
N
G
M
L
G
I
V
T
A
L
E
D
N
-----------
V
I
T
V
R
-------
M
D
N
G
R
T
-----
I
K
F
E
R
Y
T
-------------------
W
S
N
T
Q
Y
T
L
K
D
N
-------
E
-------
I
V
K
E
E
-
I
G
S
C
T
Q
F
----
P
-
L
T
L
A
W
A
I
T
I
H
K
S
Q
G
L
T
F
----
D
K
I
I
I
H
V
S
H
------
T
F
C
P
G
Q
L
Y
V
A
L
S
R
C
R
T
L
E
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
59.95
21%
-4
- C3 -
-
5LD2
-
RECD_ECOLI
D:
[154-584]
----
W
Q
K
V
A
A
A
V
A
L
-----
T
R
R
I
S
V
I
S
G
G
P
G
T
G
K
T
T
T
V
A
K
L
L
A
A
L
I
Q
MADG
E
R
C
-
R
I
R
L
A
A
P
T
G
K
A
A
A
R
L
------
T
ESLGKALRQLPLTDEQKKRIPED
A
S
T
L
H
R
L
L
G
A
Q
P
G
S
----
Q
R
-----------
L
R
H
H
A
G
N
P
L
H
L
D
--
V
L
V
V
D
E
A
S
M
I
-
D
L
P
M
M
S
R
L
I
D
A
L
P
D
---------
H
A
R
V
I
F
L
G
D
R
D
Q
L
A
S
V
E
A
G
A
V
L
G
------
D
I
C
-
A
YANA
G
F
T
A
E
-
R
A
R
Q
LSRLTGTHVPAGTGTEAAS
L
R
D
S
L
C
L
L
Q
K
S
Y
R
F
G
S
D
S
G
I
G
Q
L
A
A
A
I
N
R
G
D
--------------------
K
T
A
V
K
TVFQQD---------
F
T
D
I
--------------
E
K
R
L
L
----
Q
-----
S
GEDYIAMLEEALAGYGRYLDLLQARAEPDLIIQ
A
F
N
E
Y
Q
L
L
C
----
A
L
R
E
GPF
G
V
A
-
G
L
N
E
R
I
E
Q
F
M
Q
Q
K
-------------------
R
K
---
I
H
R
H
P
H
S
R
W
Y
E
G
R
P
V
M
I
----
A
R
N
D
S
-----------
A
L
G
L
F
N
G
D
I
G
I
A
L
D
R
G
Q
G
T
----------
R
V
W
F
A
-------
M
P
D
G
N
I
-----
K
S
V
Q
P
S
--------------------------------------------------------
R
L
P
----
E
-
H
E
T
T
W
A
M
T
V
H
K
S
Q
G
S
E
F
----
D
H
A
A
L
I
L
P
S
QRTP--
V
V
T
R
E
L
V
Y
T
A
V
T
R
A
R
R
--
R
L
S
L
Y
A
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
52.16
22%
4
- C3 -
-
3E1S
-
RECDL_DEIRA
A:
[341-690]
---
E
E
Q
A
S
V
L
D
Q
L
A
-----
G
H
R
L
V
V
L
T
G
G
P
G
T
G
K
S
T
T
T
K
A
V
A
D
L
A
E
S
----
L
G
L
-
E
V
G
L
C
A
P
T
G
K
A
A
R
R
L
------
G
E
V
T
G
R
T
-----------------
A
S
T
V
H
R
L
L
G
Y
G
P
Q
G
----
F
R
-------------
H
N
H
L
E
P
A
P
Y
D
--
L
L
I
V
D
E
V
S
M
M
-
G
D
A
L
M
L
S
L
L
A
A
V
P
---------
P
G
A
R
V
L
L
V
G
D
T
D
Q
L
P
P
V
D
A
G
L
P
-------------------
L
L
A
-
L
A
Q
---------------------
A
A
P
T
I
K
L
T
Q
V
Y
R
Q
A
A
K
N
P
I
I
Q
A
A
H
G
L
L
H
G
E
--------------------
A
P
A
W
G
---------------
D
K
R
L
N
L
T
E
I
E
PDGG
A
R
R
V
A
L
M
V
R
----
E
L
----
G
---------------------------------
G
P
G
A
V
Q
V
L
T
----
P
M
R
K
GPL
G
M
D
-
H
L
N
Y
H
L
Q
A
L
F
N
P
G
E
-------------------
G
---
G
V
R
I
A
E
G
E
A
R
P
G
D
T
V
V
Q
----
T
K
N
D
Y
-----------
N
N
E
I
F
N
G
T
L
G
M
V
L
K
A
E
G
A
-----------
R
L
T
V
D
-------
F
-
D
G
N
V
-----
V
E
L
T
G
--------------------------------------------------------
A
E
L
F
----
N
-
L
Q
L
G
Y
A
L
T
V
H
R
A
Q
G
S
E
W
----
G
T
V
L
G
V
L
H
E
AHMP--
M
L
S
R
N
L
V
Y
T
A
L
T
R
A
R
D
--
R
F
F
S
A
G
S
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
51.16
22%
1
- C3 -
-
3GP8
1
RECDL_DEIRA
A:
[192-541]
---
E
E
Q
A
S
V
L
D
Q
L
A
-----
G
H
R
L
V
V
L
T
G
G
P
G
T
G
K
S
T
T
T
K
A
V
A
D
L
A
E
S
----
L
G
L
-
E
V
G
L
C
A
P
T
G
K
A
A
R
R
L
------
G
E
V
T
G
R
T
-----------------
A
S
T
V
H
R
L
L
G
Y
G
P
Q
G
----
F
R
-------------
H
N
H
L
E
P
A
P
Y
D
--
L
L
I
V
D
E
V
S
M
M
-
G
D
A
L
M
L
S
L
L
A
A
V
P
---------
P
G
A
R
V
L
L
V
G
D
T
D
Q
L
P
P
V
D
A
G
L
P
-------------------
L
L
A
-
L
A
Q
---------------------
A
A
P
T
I
K
L
T
Q
V
Y
R
Q
A
A
K
N
P
I
I
Q
A
A
H
G
L
L
H
G
E
--------------------
A
P
A
W
G
---------------
D
K
R
L
N
L
T
E
I
E
PDG
G
A
R
R
V
A
L
M
V
R
----
E
L
----
G
---------------------------------
G
P
G
A
V
Q
V
L
T
----
P
M
R
K
GPL
G
M
D
-
H
L
N
Y
H
L
Q
A
L
F
N
P
G
E
-------------------
G
---
G
V
R
I
A
E
G
E
A
R
P
G
D
T
V
V
Q
----
T
K
N
----------------
I
F
N
G
T
L
G
M
V
L
K
A
E
G
A
-----------
R
L
T
V
D
-----------
N
V
-----
V
E
L
T
G
--------------------------------------------------------
A
E
L
F
----
N
-
L
Q
L
G
Y
A
L
T
V
H
R
A
Q
G
S
E
W
----
G
T
V
L
G
V
L
H
E
AHMP--
M
L
S
R
N
L
V
Y
T
A
L
T
R
A
R
D
--
R
F
F
S
A
G
S
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
49.52
19%
26
- C3 -
-
3UPU
1
DDA_BPT4
C:
[28-459]
---
E
G
Q
K
N
A
F
N
I
V
M
KAIKE
K
K
H
H
V
T
I
N
G
P
A
G
T
G
A
T
T
L
T
K
F
I
I
E
A
L
I
S
----
T
G
E
T
G
I
I
L
A
A
P
T
H
A
A
K
K
I
L
SKLSGK
E
-----------------------
A
S
T
I
H
S
I
L
K
I
N
P
V
T
----
Y
E
E
N
-----
V
L
F
-
E
Q
K
E
V
P
D
L
A
K
C
R
--
V
L
I
C
D
E
V
S
M
Y
-
D
R
K
L
F
K
I
L
L
S
T
I
P
P
---------
W
C
T
I
I
G
I
G
D
N
K
Q
I
R
P
V
D
P
G
E
N
------------
T
----
A
Y
I
S
P
-
F
F
T
H
-------------------
K
D
F
Y
Q
C
E
L
T
E
V
K
R
S
N
--
A
P
I
I
D
V
A
T
D
V
R
N
G
K
--------------------
W
I
Y
D
K
VVDGHGVRGFTGDTA
L
R
D
F
--------------
M
V
N
Y
F
----
S
IVKSL
D
---------------------------------
D
L
F
E
N
R
V
M
A
----
F
T
N
K
---
S
V
D
-
K
L
N
S
I
I
R
K
K
I
F
E
T
-----------------------------
D
K
D
F
I
V
G
E
I
I
V
M
----
Q
E
P
L
F
KTYKIDGKPVS
E
I
I
F
N
N
G
Q
L
V
R
I
I
E
A
E
Y
T
S
T
F
V
K
ARGVPG
E
Y
L
I
R
HWDLTVE
T
Y
G
D
D
E
YYREK
I
K
I
I
S
S
D
EELYKFNLFLGKTAETYKN
W
N
------
K
G
G
KA-----
P
-------
W
S
D
-
F
-
W
D
A
K
S
Q
F
----
S
K
V
K
A
L
P
A
S
T
F
H
K
A
Q
G
M
S
V
----
D
R
A
F
I
Y
T
P
C
IHYADV
E
L
A
Q
Q
L
L
Y
V
G
V
T
R
G
R
Y
--
D
V
F
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
49.29
16%
23
- C2 -
-
4XDN
-
SCC4_YEAST
A:
[24-640]
G
D
K
L
S
I
S
Q
V
Y
H
L
A
Q
-----
E
Y
R
D
H
A
Y
S
I
A
N
K
I
G
S
E
E
G
L
K
Q
Y
Y
G
L
M
N
M
----
S
I
Q
-
M
F
Q
L
L
K
T
K
C
T
L
S
V
L
E
------
D
-----------------------
S
K
V
T
F
E
M
V
E
L
L
I
Q
E
TYN
F
D
L
A
E
L
Y
I
S
S
L
K
E
-
R
--
L
Q
T
H
Q
S
D
T
D
L-
V
E
E
I
M
R
C
E
F
L
-
L
L
H
D
L
P
L
M
R
D
S
K
F
H
Y
K
I
A
L
R
N
C
N
E
L
V
Q
Y
M
V
N
L
-------------
Q
------
D
E
L
-
Y
----
Q
N
W
A
S
-
V
F
Q
Y
-------------------
V
G
V
M
L
C
I
K
L
K
Q
H
R
R
V
-
K
T
S
F
H
G
L
L
S
Q
C
R
E
K
S
Q
W
K
W
F
L
N
L
C
Y
V
N
Y
L
L
N
E
RFP
I
P
E
D
A
---------------
L
Q
E
L
--------------
R
S
T
E
L
----
H
-----
T
---------------------------------
V
G
---
P
E
L
Y
----
A
W
K
L
---
A
L
E
M
V
I
Q
L
C
K
D
G
N
I
T
D
H
L
N
E
F
K
N
F
F
D
T
N
K
Q
S
L
V
T
N
E
G
K
GCV
I
K
I
M
P
R
I
A
L
K
V
E
L
P
M
I
F
H
Y
K
E
L
K
N
I
L
-----------
L
L
L
Q
S
V
S
Y
I
V
N
C
Y
D
E
K
G
N
F
S
R
K
F
------
L
P
K
V
Y
-------
S
T
T
Q
K
L
-----
I
K
N
I
A
A
G
-------------------
G
V
------
S
M
N
-------
E
-------
L
D
S
-
R
-
I
Q
T
Y
K
S
I
L
E
F
C
E
-
F
Y
K
V
W
E
Q
T
L
L
K
G
A
V
V
L
G
PSPG
Y
V
R
L
L
Q
A
M
K
------
V
Q
F
E
G
G
G
A
-----
V
E
E
Y
T
R
L
A
Q
S
G
G
T
S
S
E
V
---
K
M
I
S
L
L
N
C
Y
T
V
Q
A
A
R
V
S
R
C
S
G
D
K
--
Q
G
E
L
V
E
Q
C
N
K
V
W
L
Q
V
E
K
L
L
Q
E
T
D
L
Q
F
N
P
I
W
E
C
T
V
T
I
L
W
L
F
S
H
F
E
P
FSWNPLPCS
D
K
Q
R
A
E
Y
V
S
K
L
R
E
F
Y
S
S
N
K
F
V
N
R
F
K
L
K
K
A
L
L
L
Q
I
L
V
N
Y
L
G
G
R
M
L
E
--------
H
D
L
G
E
I
Y
A
I
S
A
K
C
F
D
M
C
R
Q
Q
G
G
M
R
K
V
Q
Y
V
I
G
I
W
H
L
M
N
C
T
V
A
M
R
G
K
D
V
A
L
T
N
A
K
L
E
A
L
V
K
Q
I
T
S
32
HHSearch
48.10
21%
-12
- C3 -
-
1W36
-
RECD_ECOLI
D:
[153-583]
----
W
Q
K
V
A
A
A
V
A
L
-----
T
R
R
I
S
V
I
S
G
G
P
G
T
G
K
T
T
T
V
A
K
L
L
A
A
L
I
Q
MADG
E
R
C
-
R
I
R
L
A
A
P
T
G
K
A
A
A
R
L
------
T
ESLGKALRQLPLTDEQKKRIPED
A
S
T
L
H
R
L
L
--------------------------
H
A
G
N
P
L
H
L
D
--
V
L
V
V
D
E
A
S
M
I
-
D
L
P
M
M
S
R
L
I
D
A
L
P
D
---------
H
A
R
V
I
F
L
G
D
R
D
Q
L
A
S
V
E
A
G
A
V
L
G
------
D
I
C
A
Y
ANA-
G
F
T
A
E
-
R
A
R
Q
LSRLTGTHVPAGTGTEAAS
L
R
D
S
L
C
L
L
Q
K
S
Y
R
F
G
S
D
S
G
I
G
Q
L
A
A
A
I
N
R
G
D
--------------------
K
T
A
V
K
TVFQQD---------
F
T
D
I
--------------
E
K
R
L
L
----
Q
-----
S
GEDYIAMLEEALAGYGRYLDLLQARAEPDLIIQ
A
F
N
E
Y
Q
L
L
C
----
A
L
R
E
GPF
G
V
A
-
G
L
N
E
R
I
E
Q
F
M
Q
Q
K
-------------------
R
------------------------------------------------------------------------------------------------
Q
P
S
--------------------------------------------------------
R
L
P
----
E
-
H
E
T
T
W
A
M
T
V
H
K
S
Q
G
S
E
F
----
D
H
A
A
L
I
L
P
S
QRTP--
V
V
T
R
E
L
V
Y
T
A
V
T
R
A
R
R
--
R
L
S
L
Y
A
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
46.44
29%
-66
- C3 -
-
3GPL
2
RECDL_DEIRA
A:
[193-321]
----
E
Q
A
S
V
L
D
Q
L
A
-----
G
H
R
L
V
V
L
T
G
G
P
G
T
G
K
S
T
T
T
K
A
V
A
D
L
A
E
S
----
L
G
L
-
E
V
G
L
C
A
P
T
G
K
A
A
R
R
L
------
G
-----------------------
E
V
T
G
R
T
A
S
------------
T
V
H
R
L
L
G
Y
G
P
-
Q
G
F
R
H
N
H
L
E
P
A
P
YD
L
L
I
V
D
E
V
S
M
M
G
D
A
L
M
L
S
L
L
A
A
V
P
P
----------
G
A
R
V
L
L
V
G
D
T
D
Q
L
P
P
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
46.42
29%
-67
- C3 -
-
3GP8
1
RECDL_DEIRA
A:
[193-329]
----
E
Q
A
S
V
L
D
Q
L
A
-----
G
H
R
L
V
V
L
T
G
G
P
G
T
G
K
S
T
T
T
K
A
V
A
D
L
A
E
S
----
L
G
L
-
E
V
G
L
C
A
P
T
G
K
A
A
R
R
L
------
G
-----------------------
E
V
T
G
R
T
A
S
------------
T
V
H
R
L
L
G
Y
G
P
-
Q
G
F
R
H
N
H
L
E
P
A
P
YD
L
L
I
V
D
E
V
S
M
M
G
D
A
L
M
L
S
L
L
A
A
V
P
P
----------
G
A
R
V
L
L
V
G
D
T
D
Q
L
P
P
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
44.07
25%
-74
- C3 -
-
2QPO
-
KITH_THEMA
A:
[2-117]
-------------------
S
G
K
L
T
V
I
T
G
P
M
Y
S
G
K
T
T
E
L
L
S
F
V
E
I
Y
K
L
----
G
K
K
-
K
V
A
V
F
K
P
---------------------------------------------------
A
----
H
V
----
I
E
R
P
E
E
M
R
K
Y
I
E
---
E
D
T
R
--
G
V
F
I
D
E
V
Q
F
F
-
N
P
S
L
F
E
V
V
K
D
L
L
D
R
---------
G
I
D
V
F
C
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
43.94
29%
-61
- C3 -
-
3E1S
-
RECDL_DEIRA
A:
[342-470]
----
E
Q
A
S
V
L
D
Q
L
A
-----
G
H
R
L
V
V
L
T
G
G
P
G
T
G
K
S
T
T
T
K
A
V
A
D
L
A
E
S
----
L
G
L
-
E
V
G
L
C
A
P
T
G
K
A
A
R
R
L
------
G
-----------------------
E
V
T
G
R
T
A
S
------------
T
V
H
R
L
L
G
Y
G
P
-
Q
G
F
R
H
N
H
L
E
P
A
P
YD
L
L
I
V
D
E
V
S
M
M
G
D
A
L
M
L
S
L
L
A
A
V
P
P
----------
G
A
R
V
L
L
V
G
D
T
D
Q
L
P
P
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------