@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMC7: (2017-11-07 )
MTTSSNPPNSAAPNQTSGMWGGRFSEATDAFVAEFTASVQFDQRFYKQDIAGSIAHATMLAKVGVLTEAERDDIIEGLSTIRAEIEAGTFEWRIDLEDVHMNIESRLTQRIGITGKKLHTGRSRNDQVATDIRLYLRDEIDDILGLLERLQKGLLGLAAKNVNTIMPGFTHLQTAQPVTFGHHLLAWFEMLVRDTERLQDCRKRVNRMPLGSAALAGTTYPIDRAYTAELLGFEAVSENSLDAVSDRDFAIEFNAAASLIMMHLSRMSEELILWTSAQFKFVNIPDRFCTGSSIMPQKKNPDVPELIRGKSGRVFGDLISLLTLMKGQPLAYNKDNQEDKEPLFDAIDTVRGSLMAFADMIPALVPNVEIMREAALRGFSTATDLADYLVKKGVAFRDAHEIVGKAVALGVAEEKDLSELTLEQLQQFSDLITADVFDKALTLEASVNARDHIGGTSPKQVEAAIARAHKRLEQLYA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTTSSNPPNSAAPNQTSGMWGGRFS
E
A
T
D
A
F
V
A
E
F
T
A
S
V
Q
F
D
Q
R
F
Y
K
Q
D
I
A
G
S
I
A
H
A
T
M
L
A
K
VGVLTE
A
E
R
D
D
I
I
E
G
L
S
T
I
R
A
EIEAG
T
F
E
W
R
I
D
L
E
D
V
H
M
N
I
E
S
R
L
T
Q
R
IGITGKKLHTGRSRND
Q
V
A
T
D
I
R
L
Y
L
R
D
E
I
D
D
I
L
G
L
L
E
R
L
Q
K
G
L
L
G
L
A
AK
N
V
N
T
IMPGFTHLQTAQP
V
T
F
G
H
H
L
L
A
W
F
E
M
L
V
R
D
T
E
R
L
Q
D
C
R
K
R
VNRMPLGSAALAGTTYPI
D
R
A
Y
T
A
E
L
LG
F
E
AVSENSLDAVSDR
D
F
A
I
E
F
N
A
A
A
S
L
I
M
M
H
L
S
R
MSE
E
L
I
L
W
TS
A
Q
F
K
F
VNI
P
D
RFCTGSSIMPQKKNP
D
V
P
E
L
IRGKSG
R
V
F
G
D
L
I
S
L
L
T
LMKGQPLAYNKDNQ
E
D
K
E
P
L
F
D
A
I
D
T
V
R
G
S
L
M
A
F
A
D
M
I
P
A
LVP
N
V
E
I
M
R
E
A
A
LRGFS
T
A
T
D
L
A
D
Y
L
V
KKGVA
F
R
D
A
H
E
I
V
G
K
A
V
ALGVAEEK
D
L
S
E
L
T
L
E
Q
L
Q
Q
F
S
D
L
I
T
A
D
V
FDK
A
L
T
L
E
A
SVNARDHIGGT
S
P
K
Q
V
E
A
A
I
A
R
A
H
K
R
L
E
Q
LYA
12
PsiBlast_PDB
85.68
43%
-91
- C3 -
-
1K62
-
ARLY_HUMAN
A:
[15-460]
-------------------------
G
A
V
D
P
I
M
E
K
F
N
A
S
I
A
Y
D
R
H
L
W
E
V
D
V
Q
G
S
K
A
Y
S
R
G
L
E
K
A
G
L
L
T
K
A
E
M
D
Q
I
L
H
G
L
D
K
V
A
E
E
W
A
Q
G
T
F
K
L
N
S
N
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
A
T
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
R
L
W
M
R
Q
T
C
S
T
L
S
G
L
L
W
E
L
I
R
T
M
V
D
R
A
E
A
E
R
D
V
L
F
P
G
Y
T
H
L
Q
R
A
Q
P
I
R
W
S
H
W
I
L
S
H
A
V
A
L
T
R
D
S
E
R
L
L
E
V
R
K
R
I
N
V
L
P
L
G
S
G
A
I
A
G
N
P
L
G
V
D
R
E
L
L
R
A
E
L
N
F
G
A
I
T
L
N
S
M
D
A
T
S
E
R
D
F
V
A
E
F
L
F
W
R
S
L
C
M
T
H
L
S
R
M
A
E
D
L
I
L
Y
C
T
K
E
F
S
F
V
Q
L
S
D
A
Y
S
T
G
S
S
L
M
P
R
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
C
A
G
L
L
M
T
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
E
V
S
D
T
M
S
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
H
Q
E
N
M
G
Q
-
A
L
S
P
D
M
L
A
T
D
L
A
Y
Y
L
V
R
K
G
M
P
F
R
Q
A
H
E
A
S
G
K
A
V
F
M
A
E
T
K
G
V
A
L
N
Q
L
S
L
Q
E
L
Q
T
I
S
P
L
F
S
G
D
V
I
-
C
V
W
D
Y
R
H
S
V
E
Q
Y
G
A
L
G
G
T
A
R
S
S
V
D
W
Q
I
R
Q
V
R
A
L
L
Q
----
5
PsiBlast_PDB
83.52
44%
-95
- C3 -
-
1TJU
-
ARLY2_ANAPL
A:
[19-454]
---------------------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
I
L
P
G
Y
S
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
-
E
K
A
L
T
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
A
G
T
A
K
S
S
V
T
T
Q
I
------------
7
PsiBlast_PDB
83.43
44%
-93
- C3 -
-
1TJV
-
ARLY2_ANAPL
A:
[19-454]
---------------------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
I
L
P
G
Y
D
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
-
E
K
A
L
T
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
A
G
T
A
K
S
S
V
T
T
Q
I
------------
4
PsiBlast_PDB
83.35
45%
-92
- C3 -
-
1HY1
-
ARLY2_ANAPL
A:
[17-452]
---------------------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
I
L
P
G
Y
T
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
-
E
K
A
L
T
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
A
G
T
A
K
S
S
V
T
T
Q
I
------------
25
PsiBlast_CBE
83.20
45%
-92
- C3 -
-
1K7W
3
ARLY2_ANAPL
D:
[18-454]
--------------------------
S
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
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L
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G
D
I
A
G
K
L
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T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
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T
L
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R
A
A
I
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I
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V
I
L
P
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T
H
L
Q
K
A
Q
P
I
R
W
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Q
F
L
L
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H
A
V
A
L
T
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R
L
G
E
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K
K
R
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N
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L
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A
L
A
G
N
P
L
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L
E
F
A
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I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
A
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
-
E
K
A
L
T
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
G
G
T
A
K
S
S
V
T
T
Q
I
------------
53
HHSearch
83.07
43%
-93
* C3 *
-
1K7W
3
ARLY2_ANAPL
C:
[19-464]
---------------------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
I
L
P
G
Y
T
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
A
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
E
K
A
L
T
-
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
S
Q
-
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
G
G
T
A
K
S
S
V
T
T
Q
I
E
Q
L
R
E
L
M
K
K
Q
--
26
PsiBlast_CBE
82.65
45%
-92
- C3 -
-
1K7W
3
ARLY2_ANAPL
C:
[19-454]
---------------------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
I
L
P
G
Y
T
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
A
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
-
E
K
A
L
T
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
G
G
T
A
K
S
S
V
T
T
Q
I
------------
52
HHSearch
82.60
43%
-91
- C3 -
-
1K62
-
ARLY_HUMAN
B:
[6-463]
----------------
G
K
L
W
G
G
R
F
V
G
A
V
D
P
I
M
E
K
F
N
A
S
I
A
Y
D
R
H
L
W
E
V
D
V
Q
G
S
K
A
Y
S
R
G
L
E
K
A
G
L
L
T
K
A
E
M
D
Q
I
L
H
G
L
D
K
V
A
E
E
W
A
Q
G
T
F
K
L
N
S
N
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
A
T
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
R
L
W
M
R
Q
T
C
S
T
L
S
G
L
L
W
E
L
I
R
T
M
V
D
R
A
E
A
E
R
D
V
L
F
P
G
Y
T
H
L
Q
R
A
Q
P
I
R
W
S
H
W
I
L
S
H
A
V
A
L
T
R
D
S
E
R
L
L
E
V
R
K
R
I
N
V
L
P
L
G
S
G
A
I
A
G
N
P
L
G
V
D
R
E
L
L
R
A
E
L
N
F
G
A
I
T
L
N
S
M
D
A
T
S
E
R
D
F
V
A
E
F
L
F
W
R
S
L
C
M
T
H
L
S
R
M
A
E
D
L
I
L
Y
C
T
K
E
F
S
F
V
Q
L
S
D
A
Y
S
T
G
S
S
L
M
P
R
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
C
A
G
L
L
M
T
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
E
V
S
D
T
M
S
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
H
Q
E
N
M
G
Q
A
L
S
-
P
D
M
L
A
T
D
L
A
Y
Y
L
V
R
K
G
M
P
F
R
Q
A
H
E
A
S
G
K
A
V
F
M
A
E
T
K
G
V
A
L
N
Q
L
S
L
Q
E
L
Q
T
I
S
P
L
F
S
G
D
V
I
C
-
V
W
D
Y
R
H
S
V
E
Q
Y
G
A
L
G
G
T
A
R
S
S
V
D
W
Q
I
R
Q
V
R
A
L
L
Q
A
Q
Q
-
27
PsiBlast_CBE
82.33
45%
-88
- C3 -
-
1K7W
3
ARLY2_ANAPL
B:
[18-454]
--------------------------
S
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
I
L
P
G
Y
T
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
A
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
-
E
K
A
L
T
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
G
G
T
A
K
S
S
V
T
T
Q
I
------------
16
PsiBlast_PDB
82.20
40%
-98
- C3 -
-
1I0A
-
ARLY1_MELGA
A:
[11-461]
---------------------
G
R
F
V
G
S
V
D
P
I
M
E
I
L
S
S
S
I
S
T
E
Q
R
L
T
E
V
D
I
Q
A
S
M
A
Y
A
K
A
L
E
K
A
S
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
S
S
K
G
V
L
V
M
T
Q
S
D
E
D
I
Q
T
A
I
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
Q
T
G
R
S
R
N
E
Q
V
V
T
D
L
K
L
L
L
K
S
S
I
S
V
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
I
I
M
P
G
Y
T
H
L
Q
K
A
L
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
T
V
L
P
L
G
S
G
V
L
A
G
N
P
L
E
I
D
R
E
L
L
R
S
E
L
D
M
T
S
I
T
L
N
S
I
D
A
I
S
E
R
D
F
V
V
E
L
I
S
V
A
T
L
L
M
I
H
L
S
K
L
A
E
D
L
I
I
F
S
T
T
E
F
G
F
V
T
L
S
D
A
Y
S
T
G
S
S
L
L
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
A
I
L
M
V
L
K
G
I
P
S
T
F
S
K
D
L
Q
E
D
K
E
A
V
L
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
N
K
E
N
M
-
E
K
A
L
T
P
E
L
L
S
T
D
L
A
L
Y
L
V
R
K
G
M
P
I
R
Q
A
Q
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
N
L
T
L
E
D
L
K
S
I
S
P
L
F
A
S
D
V
-
S
Q
V
F
S
V
V
N
S
V
E
Q
Y
T
A
V
G
G
T
A
K
S
S
V
T
A
Q
I
E
Q
L
R
E
L
L
K
K
---
32
PsiBlast_CBE
82.14
43%
-98
- C3 -
-
1DCN
1
ARLY2_ANAPL
D:
[3-445]
-----------------------------
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
N
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
I
L
P
G
Y
T
N
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
---------
N
P
D
S
L
E
L
I
R
S
K
S
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
-
E
K
A
L
T
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
N
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
A
G
T
A
K
S
S
V
T
T
Q
I
E
Q
L
R
E
L
M
K
K
---
15
PsiBlast_PDB
82.06
43%
-104
- C3 -
-
1DCN
1
ARLY2_ANAPL
A:
[15-445]
-----------------------------------------
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
N
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
I
L
P
G
Y
T
N
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
---------
N
P
D
S
L
E
L
I
R
S
K
S
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
-
E
K
A
L
T
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
N
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
A
G
T
A
K
S
S
V
T
T
Q
I
E
Q
L
R
E
L
M
K
K
---
11
PsiBlast_PDB
82.04
44%
-93
- C3 -
-
1U16
1
ARLY1_ANAPL
A:
[16-452]
--------------------------
S
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
A
S
I
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
E
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
I
L
P
G
Y
T
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
V
A
T
L
L
L
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
I
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
-
E
K
A
L
T
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
M
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
A
I
N
N
L
T
L
E
D
L
K
S
I
S
P
L
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
G
G
T
A
K
S
S
V
T
T
Q
I
------------
6
PsiBlast_PDB
81.92
45%
-89
- C3 -
-
1AUW
-
ARLY2_ANAPL
A:
[17-452]
---------------------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
N
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
I
L
P
G
Y
T
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
D
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
-
E
K
A
L
T
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
G
G
T
A
K
S
S
V
T
T
Q
I
------------
3
PsiBlast_PDB
81.91
45%
-89
- C3 -
-
1K7W
3
ARLY2_ANAPL
A:
[19-454]
---------------------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
I
L
P
G
Y
T
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
A
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
-
E
K
A
L
T
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
G
G
T
A
K
S
S
V
T
T
Q
I
------------
30
PsiBlast_CBE
81.88
44%
-90
- C3 -
-
1TJW
2
ARLY2_ANAPL
B:
[20-454]
----------------------------
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
I
L
P
G
Y
D
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
-
E
K
A
L
T
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
A
G
T
A
K
S
S
V
T
T
Q
I
------------
29
PsiBlast_CBE
81.84
44%
-90
- C3 -
-
1TJW
2
ARLY2_ANAPL
C:
[20-454]
----------------------------
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
I
L
P
G
Y
D
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
-
E
K
A
L
T
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
A
G
T
A
K
S
S
V
T
T
Q
I
------------
10
PsiBlast_PDB
81.69
44%
-94
- C3 -
-
1U15
-
ARLY1_ANAPL
A:
[17-452]
---------------------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
A
S
I
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
E
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
I
L
P
G
Y
T
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
V
A
T
L
L
L
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
I
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
-
E
K
A
L
T
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
M
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
A
I
N
N
L
T
L
E
D
L
K
S
I
S
P
L
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
G
G
T
A
K
S
S
V
T
T
Q
I
------------
8
PsiBlast_PDB
81.56
44%
-90
- C3 -
-
1TJW
2
ARLY2_ANAPL
A:
[19-454]
---------------------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
R
A
A
I
E
I
D
V
I
L
P
G
Y
D
H
L
Q
K
A
Q
P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
E
D
L
I
I
Y
S
T
S
E
F
G
F
L
T
L
S
D
A
F
S
T
G
S
S
L
M
P
Q
K
K
N
P
D
S
L
E
L
I
R
S
K
A
G
R
V
F
G
R
L
A
S
I
L
M
V
L
K
G
L
P
S
T
Y
N
K
D
L
Q
E
D
K
E
A
V
F
D
V
V
D
T
L
T
A
V
L
Q
V
A
T
G
V
I
S
T
L
Q
I
S
K
E
N
M
-
E
K
A
L
T
P
E
M
L
A
T
D
L
A
L
Y
L
V
R
K
G
V
P
F
R
Q
A
H
T
A
S
G
K
A
V
H
L
A
E
T
K
G
I
T
I
N
K
L
S
L
E
D
L
K
S
I
S
P
Q
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
A
G
T
A
K
S
S
V
T
T
Q
I
------------
28
PsiBlast_CBE
81.21
44%
-93
- C3 -
-
1TJW
2
ARLY2_ANAPL
D:
[19-454]
---------------------------
T
D
P
I
M
E
K
L
N
S
S
I
A
Y
D
Q
R
L
S
E
V
D
I
Q
G
S
M
A
Y
A
K
A
L
E
K
A
G
I
L
T
K
T
E
L
E
K
I
L
S
G
L
E
K
I
S
E
E
W
S
K
G
V
F
V
V
K
Q
S
D
E
D
I
H
T
A
N
E
R
R
L
K
E
L
I
G
D
I
A
G
K
L
H
T
G
R
S
R
N
D
Q
V
V
T
D
L
K
L
F
M
K
N
S
L
S
I
I
S
T
H
L
L
Q
L
I
K
T
L
V
E
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A
A
I
E
I
D
V
I
L
P
G
Y
D
H
L
Q
K
A
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P
I
R
W
S
Q
F
L
L
S
H
A
V
A
L
T
R
D
S
E
R
L
G
E
V
K
K
R
I
N
V
L
P
L
G
S
G
A
L
A
G
N
P
L
D
I
D
R
E
M
L
R
S
E
L
E
F
A
S
I
S
L
N
S
M
D
A
I
S
E
R
D
F
V
V
E
F
L
S
F
A
T
L
L
M
I
H
L
S
K
M
A
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D
L
I
I
Y
S
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F
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F
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S
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A
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-
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L
A
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L
A
L
Y
L
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G
V
P
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A
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T
A
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K
A
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H
L
A
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T
K
G
I
T
I
N
K
L
S
L
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D
L
K
S
I
S
P
Q
F
S
S
D
V
-
S
Q
V
F
N
F
V
N
S
V
E
Q
Y
T
A
L
A
G
T
A
K
S
S
V
T
T
Q
I
------------