@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VME9: (2017-11-07 )
MECDVKPVRLAILGLGTVGGGALKLLQENAAEIKRRTGREIQITHVGTRRPRPDLELEGIKQSADLLDIVRQPDVDVVVEVMGGIHPAYEIIMEAIKHGKQVVTANKALLAKHGNELFKAAEDNAVQIAYEAAVAGGIPIIKVIREGLAANHIEWLAGIINGTGNFILTEMREKGRAFDDVLKEAQELGYAEADPTFDVEGIDAAHKLTILASCAFGIPLQFDKVYTEGISKITAQDVKYAEELGFRIKHLGIARRAEKGIELRVHPTLIPDEQLIANVNGVKNAVLVQANAVGPTLYYGAGAGAGPTASAVVADVIDIVRDISYTEDGAGTIPQLAFEALTNMPILSREEMTTGYYIRLNAEDQTGVLADVTTILSRAGISIDAIMQQSRLKDLIPIVILTDPIVESKMDDALAQIQALPAIRGEIVRIRLESLDS
Atome Classification :
(20 SA)
.........10........20........-30........40.....----...50.------------....----------.---.------------..--60---.......-----------------..70---.........80----....----..----..----.90........100.......110--........120.......130.......140......-.150.......160.......170..---.....180.......190.......200.......210.......220.......230---..----------...------....240.....----..250.......260..--...-..270.......280.......290..-.....300.......310.......320.......330.......340.........350.......360.......370.......380.......-390.......400.......410.......420.......430.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MECDV
K
P
V
R
L
A
I
L
G
LGTVG
G
G
A
L
K
L
L
Q
E
N
-
A
A
E
I
K
R
RTG
R
E
I
Q
I
T
HV----GTRR-P------------RPDL----------
E
---
L
------------
E
G
--
I
----KQ
S
A
D
L
L
-----------------
D
I
V----RQP
D
V
D
V
V
V
E
-----
V
MGG----I
H
----
P
A
----
Y
E
I
I
M
E
A
I
KHG
K
Q
V
VTA
N
K
A
L
L
A
---KH
G
N
E
L
F
KAAED
N
A
V
Q
I
A
Y
E
A
AVAGG
I
P
I
I
K
V
I
R
E
G
L-A
A
N
H
I
E
W
L
A
G
I
INGTG
N
F
I
L
T
E
M
R
E
K---G
R
A
F
D
D
V
L
K
E
A
Q
ELGYAEADPTFDVEGIDA
A
H
K
L
T
I
L
ASCAFGIPL
Q
F
D
K
V
Y
T
E
G
I
-----
S
K
----------
I
T
A
------
Q
D
V
K
Y
A
E
E
LG
F
R
----
I
K
H
LG
I
A
R
R
AEKG
I
E
L
R
--
V
HP-TLI
P
D
E
Q
L
I
A
NVNGV
K
N
A
V
L
V
Q
ANAVG-P
T
L
Y
YGAGAGAGP
T
A
S
A
V
V
A
D
V
I
D
I
V
R
DISYTEDGAG
T
I
P
Q
L
A
F
E
A
--LTNMPILSREEMT
T
G
Y
Y
I
R
LNAEDQT
G
V
L
A
D
V
T
T
I
L
S
RAGI
S
I
D
A
I
M
Q
Q
-
S
R
L
K
DL
I
P
I
V
I
LT
D
P
I
V
E
S
K
M
D
D
A
L
A
Q
I
Q
A
L
P
AIR
G
E
I
V
R
I
R
L
E
SLDS
39
HHSearch
87.85
59%
-38
- C3 -
-
3MTJ
-
?
A:
[6-442]
--
Q
G
M
K
P
I
H
V
G
L
L
G
L
G
T
V
G
G
G
T
L
T
V
L
R
R
N
-
A
E
E
I
T
R
R
A
G
R
E
I
R
V
V
R
A
----
A
V
R
N
-
L
------------
D
K
A
E
----------
A
---
L
A-----------
G
G
--
L
----
P
L
T
T
N
P
F
-----------------
D
V
V
----
D
D
P
E
I
D
I
V
V
E
-----
L
I
G
G
----
L
E
----
P
A
----
R
E
L
V
M
Q
A
I
A
N
G
K
H
V
V
T
A
N
K
H
L
V
A
---
K
Y
G
N
E
I
F
A
A
A
Q
A
K
G
V
M
V
T
F
E
A
A
V
A
G
G
I
P
I
I
K
A
L
R
E
G
L
-
T
A
N
R
I
E
W
L
A
G
I
I
N
G
T
S
N
F
I
L
S
E
M
R
D
K
---
G
A
A
F
D
D
V
L
K
E
A
Q
R
L
G
Y
A
E
A
D
P
T
F
D
I
E
G
I
D
A
A
H
K
L
T
I
L
S
A
I
A
F
G
I
P
M
Q
F
E
R
A
Y
T
E
G
I
-----
S
Q
----------
L
T
R
------
E
D
V
R
Y
A
E
E
L
G
Y
R
----
I
K
L
L
G
I
A
R
R
A
E
N
G
I
E
L
R
--
V
H
P
-
T
L
I
P
E
R
R
L
I
A
N
V
D
G
A
M
N
A
V
L
V
K
G
D
A
V
G
-
P
T
L
Y
Y
G
A
G
A
G
S
E
P
T
A
S
A
V
V
A
D
L
V
D
V
T
R
L
H
T
A
D
P
H
--
H
R
V
P
H
L
A
F
Q
P
DQ
L
A
D
T
P
I
L
P
M
E
A
V
R
T
A
Y
Y
L
R
L
R
A
F
-
R
P
G
V
L
A
D
I
T
R
I
L
A
D
S
S
I
S
I
D
A
M
V
Q
K
-
E
----
Q
V
D
I
I
L
L
T
H
V
T
L
E
K
N
V
N
A
A
I
A
K
I
E
A
L
D
A
V
A
G
K
V
M
R
I
R
L
E
D
L
G
-
1
PsiBlast_PDB
81.61
58%
-24
- C3 -
-
3MTJ
-
?
A:
[30-441]
--------------------------
R
R
N
-
A
E
E
I
T
R
R
A
G
R
E
I
R
V
V
R
A
----
A
V
R
N
L
D
------------
K
A
E
A
----------
L
---
A
------------
G
G
--
L
----
P
L
T
T
N
P
F
-----------------
D
V
V
----
D
D
P
E
I
D
I
V
V
E
-----
L
I
G
G
----
L
E
----
P
A
----
R
E
L
V
M
Q
A
I
A
N
G
K
H
V
V
T
A
N
K
H
L
V
A
---
K
Y
G
N
E
I
F
A
A
A
Q
A
K
G
V
M
V
T
F
E
A
A
V
A
G
G
I
P
I
I
K
A
L
R
E
G
L
-
T
A
N
R
I
E
W
L
A
G
I
I
N
G
T
S
N
F
I
L
S
E
M
R
D
K
---
G
A
A
F
D
D
V
L
K
E
A
Q
R
L
G
Y
A
E
A
D
P
T
F
D
I
E
G
I
D
A
A
H
K
L
T
I
L
S
A
I
A
F
G
I
P
M
Q
F
E
R
A
Y
T
E
G
I
-----
S
Q
----------
L
T
R
------
E
D
V
R
Y
A
E
E
L
G
Y
R
----
I
K
L
L
G
I
A
R
R
A
E
N
G
I
E
L
R
--
V
H
P
-
T
L
I
P
E
R
R
L
I
A
N
V
D
G
A
M
N
A
V
L
V
K
G
D
A
V
G
-
P
T
L
Y
Y
G
A
G
A
G
S
E
P
T
A
S
A
V
V
A
D
L
V
D
V
T
R
--
L
H
T
A
D
P
H
H
R
V
P
H
L
A
F
Q
P
DQ
L
A
D
T
P
I
L
P
M
E
A
V
R
T
A
Y
Y
L
R
L
R
A
F
-
R
P
G
V
L
A
D
I
T
R
I
L
A
D
S
S
I
S
I
D
A
M
V
Q
K
E-----
Q
V
D
I
I
L
L
T
H
V
T
L
E
K
N
V
N
A
A
I
A
K
I
E
A
L
D
A
V
A
G
K
V
M
R
I
R
L
E
D
L
--
30
Fugue
69.06
35%
-118
- C3 -
-
2EJW
-
?
A:
[1-331]
----
M
E
A
L
K
I
A
L
L
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
-
A
E
E
L
S
A
F
-
G
V
V
P
R
F
L
G
V
----
L
V
R
D
-
P
------------
R
K
P
R
----------
A
---
I
------------
P
Q
--
E
----
L
L
R
A
E
P
F
-----------------
D
-------
L
L
E
A
D
L
V
V
E
-----
A
M
G
G
----
V
E
----
A
P
----
L
R
L
V
L
P
A
L
E
A
G
I
P
L
I
T
A
N
K
A
L
L
A
---
E
A
W
E
S
L
R
P
F
A
E
E
G
L
--
I
Y
H
E
A
S
V
M
A
G
T
P
A
L
S
F
L
-
E
T
L
-
R
G
S
E
L
L
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
M
E
K
----
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
L
A
R
L
L
V
D
P
G
F
P
F
A
E
V
E
A
Q
G
I
-----
A
R
----------
L
T
P
------
E
V
L
Q
K
A
E
A
R
G
E
R
----
V
R
L
V
A
S
L
F
G
E
G
G
R
W
R
A
A
--
V
A
P
-
R
R
L
P
Q
D
H
P
L
A
R
A
R
G
--
N
A
L
W
V
R
A
R
P
L
G
-
E
A
F
V
T
G
P
G
A
G
G
G
A
T
A
S
G
L
F
A
D
L
L
R
F
L
S
G
A
P
G
H
L
P
A
P
R
A
R
P
P
-
L
E
E
G
--
S
P
W
P
G
V
--------------------------------------------------------------------------------------------
23
PsiBlast_CBE
64.72
37%
-135
- C3 -
-
2EJW
1
?
E:
[4-280]
-------
L
K
I
A
L
L
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
-
A
E
E
L
S
A
-
F
G
V
V
P
R
F
L
G
V
----
L
V
R
D
-
P
------------
R
K
P
R
----------
A
---
I
------------
P
Q
--
E
----
L
L
R
A
E
P
F
-----------------
D
L
L
-------
E
A
D
L
V
V
E
-----
A
M
G
G
----
V
E
----
A
P
----
L
R
L
V
L
P
A
L
E
A
G
I
P
L
I
T
A
N
K
A
L
L
A
---
E
A
W
E
S
L
R
P
F
A
E
E
G
L
--
I
Y
H
E
A
S
V
M
A
G
T
P
A
L
S
F
L
-
E
T
L
-
R
G
S
E
L
L
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
M
-
E
K
---
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
L
A
R
L
L
V
D
P
G
F
P
F
A
E
V
E
A
Q
G
I
-----
A
R
----------
L
T
P
------
E
V
L
Q
K
A
E
A
R
G
E
R
----
V
R
L
--
V
A
S
L
F
G
E
G
G
R
W
R
AA
V
A
P
-
R
R
L
P
Q
D
H
P
L
A
R
A
R
G
--
N
A
L
W
V
R
A
R
P
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
64.02
37%
-132
- C3 -
-
2EJW
1
?
B:
[4-280]
-------
L
K
I
A
L
L
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
-
A
E
E
L
S
A
-
F
G
V
V
P
R
F
L
G
V
----
L
V
R
D
-
P
------------
R
K
P
R
----------
A
---
I
------------
P
Q
--
E
----
L
L
R
A
E
P
F
-----------------
D
L
L
-------
E
A
D
L
V
V
E
-----
A
M
G
G
----
V
E
----
A
P
----
L
R
L
V
L
P
A
L
E
A
G
I
P
L
I
T
A
N
K
A
L
L
A
---
E
A
W
E
S
L
R
P
F
A
E
E
G
L
--
I
Y
H
E
A
S
V
M
A
G
T
P
A
L
S
F
L
-
E
T
L
-
R
G
S
E
L
L
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
M
-
E
K
---
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
L
A
R
L
L
V
D
P
G
F
P
F
A
E
V
E
A
Q
G
I
-----
A
R
----------
L
T
P
------
E
V
L
Q
K
A
E
A
R
G
E
R
----
V
R
L
--
V
A
S
L
F
G
E
G
G
R
W
R
AA
V
A
P
-
R
R
L
P
Q
D
H
P
L
A
R
A
R
G
--
N
A
L
W
V
R
A
R
P
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
63.97
37%
-130
- C3 -
-
2EJW
-
?
A:
[4-280]
-------
L
K
I
A
L
L
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
-
A
E
E
L
S
A
-
F
G
V
V
P
R
F
L
G
V
----
L
V
R
D
-
P
------------
R
K
P
R
----------
A
---
I
------------
P
Q
--
E
----
L
L
R
A
E
P
F
-----------------
D
L
L
-------
E
A
D
L
V
V
E
-----
A
M
G
G
----
V
E
----
A
P
----
L
R
L
V
L
P
A
L
E
A
G
I
P
L
I
T
A
N
K
A
L
L
A
---
E
A
W
E
S
L
R
P
F
A
E
E
G
L
--
I
Y
H
E
A
S
V
M
A
G
T
P
A
L
S
F
L
-
E
T
L
-
R
G
S
E
L
L
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
M
-
E
K
---
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
L
A
R
L
L
V
D
P
G
F
P
F
A
E
V
E
A
Q
G
I
-----
A
R
----------
L
T
P
------
E
V
L
Q
K
A
E
A
R
G
E
R
----
V
R
L
--
V
A
S
L
F
G
E
G
G
R
W
R
A
A
V
A
P
-
R
R
L
P
Q
D
H
P
L
A
R
A
R
G
--
N
A
L
W
V
R
A
R
P
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
63.38
37%
-130
- C3 -
-
5XDF
2
?
A:
[4-280]
-------
L
K
I
A
L
L
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
-
A
E
E
L
S
A
-
F
G
V
V
P
R
F
L
G
V
----
L
V
R
D
-
P
---------------
R
----------
A
---
I
------------
P
Q
--
E
----
L
L
R
A
E
P
F
-----------------
D
L
L
-------
E
A
D
L
V
V
E
-----
A
M
G
G
----
V
E
----
A
P
----
L
R
L
V
L
P
A
L
E
A
G
I
P
L
I
T
A
N
K
A
L
L
A
---
E
A
W
E
S
L
R
P
F
A
E
E
G
L
--
I
Y
H
E
A
S
V
M
A
G
T
P
A
L
S
F
L
-
E
T
L
-
R
G
S
E
L
L
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
M
-
E
K
---
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
L
A
R
L
L
V
D
P
G
F
P
F
A
E
V
E
A
Q
G
I
-----
A
R
----------
L
T
P
------
E
V
L
Q
K
A
E
A
R
G
E
R
----
V
R
L
--
V
A
S
L
F
G
E
G
G
R
W
R
A
A
V
A
P
-
R
R
L
P
Q
D
H
P
L
A
R
A
R
G
--
N
A
L
W
V
R
A
R
P
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
61.74
37%
-127
- C3 -
-
5XDF
2
?
B:
[4-282]
-------
L
K
I
A
L
L
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
-
A
E
E
L
S
A
-
F
G
V
V
P
R
F
L
G
V
----
L
V
R
D
-
P
------------
R
K
P
R
----------
A
---
I
------------
P
Q
--
E
----
L
L
R
A
E
P
F
-----------------
D
L
L
-------
E
A
D
L
V
V
E
-----
A
M
G
G
----
V
E
----
A
P
----
L
R
L
V
L
P
A
L
E
A
G
I
P
L
I
T
A
N
K
A
L
L
A
---
E
A
W
E
S
L
R
P
F
A
E
E
G
L
--
I
Y
H
E
A
S
V
M
A
G
T
P
A
L
S
F
L
-
E
T
L
-
R
G
S
E
L
L
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
M
-
E
K
---
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
L
A
R
L
L
V
D
P
G
F
P
F
A
E
V
E
A
Q
G
I
-----
A
R
----------
L
T
P
------
E
V
L
Q
K
A
E
A
R
G
E
R
----
V
R
L
--
V
A
S
L
F
G
E
G
G
R
W
R
A
A
V
A
P
-
R
R
L
P
Q
D
H
P
L
A
R
A
R
G
--
N
A
L
W
V
R
A
R
P
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
61.72
36%
-64
- C3 -
-
2EJW
1
?
B:
[1-309]
----
M
E
A
L
K
I
A
L
L
G
G
G
T
V
G
S
A
F
Y
N
L
V
L
E
R
-
A
E
E
L
S
-
A
F
G
V
V
P
R
F
L
G
V
----
L
V
R
D
-
P
------------
R
K
P
R
----------
A
---
I
------------
P
---
Q
----
E
L
L
R
A
-------------------
E
P
F
----
D
L
L
E
A
D
L
V
V
E
-----
A
M
G
G
-----
V
E---
A
P
----
L
R
L
V
L
P
A
L
E
A
G
I
P
L
I
T
A
N
K
A
L
L
A
---
E
A
W
E
S
L
R
P
F
A
E
E
G
--
L
I
Y
H
E
A
S
V
M
A
G
T
P
A
L
S
F
L
E
T
L
R
--
G
S
E
L
L
E
L
H
G
I
L
N
G
T
T
L
Y
I
L
Q
E
M
E
K
----
G
R
T
Y
A
E
A
L
L
E
A
Q
R
L
G
Y
A
E
A
D
P
T
L
D
V
E
G
I
D
A
A
H
K
L
T
L
L
A
R
L
L
V
D
P
G
F
P
F
A
E
V
E
A
Q
G
I
-----
A
R
----------
L
T
P
------
E
V
L
Q
K
A
E
A
R
G
E
R
----
V
R
L
V
A
S
L
F
G
E
G
G
R
W
R
A
A
--
V
A
P
-
R
R
L
P
Q
D
H
P
L
A
R
A
R
G
--
N
A
L
W
V
R
A
R
P
L
G
-
E
A
F
V
T
G
P
G
A
G
G
G
A
T
A
S
G
L
F
A
D
L
L
R
F
L
S
G
A
---------------------------------------------------------------------------------------------------------------------
42
HHSearch
61.41
38%
-17
* C3 *
-
3DO5
1
?
A:
[2-325]
------
M
I
K
I
A
I
V
G
F
G
T
V
G
Q
G
V
A
E
L
L
I
R
K
-
R
E
E
I
E
K
A
I
G
-
E
F
K
V
T
A
V
----
A
D
S
K
-
S
------------
S
I
S
G
----------
D
---
F
S
L
V
E
A
L
R
M
K
R
E
T
G
M
--
L
----
R
D
D
A
K
A
I
-----------------
E
V
V
----
R
S
A
D
Y
D
V
L
I
E
-----
A
S
V
T
R---------
E
G
----
V
N
Y
I
R
E
A
L
K
R
G
K
H
V
V
T
S
N
K
G
P
L
V
---
A
E
F
H
G
L
M
S
L
A
E
R
N
G
V
R
L
M
Y
E
A
T
V
G
G
A
M
P
V
V
K
L
A
K
R
Y
L
-
A
L
C
E
I
E
S
V
K
G
I
F
N
G
T
C
N
Y
I
L
S
R
M
E
E
E
---
R
L
P
Y
E
H
I
L
K
E
A
Q
E
L
G
Y
A
E
A
D
P
S
Y
D
V
E
G
I
D
A
A
L
K
L
V
I
I
A
N
T
-
I
G
V
K
A
S
Y
E
D
V
E
V
T
G
I
-----
T
Q
----------
I
T
P
------
E
A
F
Q
V
A
A
E
K
G
Y
T
----
I
R
L
I
A
E
V
S
R
----
E
K
L
K
--
V
S
P
-
R
L
V
P
F
H
H
P
L
A
-
I
K
G
T
M
N
A
A
M
F
K
T
D
T
A
G
-
S
I
F
V
A
G
R
G
A
G
K
E
E
T
A
S
A
I
L
S
D
L
Y
E
I
Y
A
G
----------------------------------------------------------------------------------------------------------------------
32
Fugue
58.09
34%
10
- C3 -
-
4PG7
4
?
A:
[20-446]
---
H
M
K
K
L
N
I
A
L
L
G
L
G
T
V
G
S
G
V
V
K
I
I
E
E
N
-
R
Q
Q
I
Q
D
T
L
N
K
D
I
V
I
K
H
I
L
V
--
R
D
K
S
-
K
------------
K
R
P
L
----------
N
---
I
------------
S
Q
--
Y
----
H
L
T
E
D
V
N
-----------------
E
I
L
----
N
D
D
S
L
D
I
I
V
E
-----
V
M
G
G
----
I
E
----
P
T
----
V
D
W
L
R
T
A
L
K
N
K
K
H
V
I
T
A
N
K
D
L
L
A
---
V
H
L
K
L
L
E
D
L
A
E
E
N
G
V
A
L
K
F
E
A
S
V
A
G
G
-------------
P
N
N
I
S
K
F
M
G
I
L
N
G
T
S
N
F
I
L
S
K
M
T
K
E
---
Q
T
T
F
E
E
A
L
D
E
A
K
R
L
G
F
A
E
A
D
P
T
D
D
V
E
G
V
D
A
A
R
K
V
V
I
T
S
Y
L
S
F
N
Q
V
I
K
L
N
D
V
K
R
R
G
I
-----
S
G
----------
V
T
L
------
T
D
I
N
V
A
D
Q
L
G
Y
K
----
I
K
L
I
G
K
G
I
Y
E
N
G
K
V
N
A
S
--
V
E
P
-
T
L
I
D
K
K
H
Q
L
A
A
V
E
D
E
Y
N
A
I
Y
V
I
G
D
A
V
G
-
D
T
M
F
Y
G
K
G
A
G
S
L
A
T
G
S
A
V
V
S
D
L
L
N
V
A
L
F
F
E
S
T
L
P
P
H
-------
F
E
L
--
K
T
D
---
K
T
R
E
M
E
K
S
N
F
F
V
V
V
N
--
H
V
K
G
S
I
E
N
F
E
N
E
L
K
A
I
-
L
P
F
H
R
S
L
R
V
-
A
N
Y
D
N
Q
S
Y
A
A
V
I
V
G
--
L
E
S
S
P
E
E
L
I
T
K
-------
H
G
Y
E
V
D
K
V
Y
P
V
E
G
V
2
PsiBlast_PDB
57.32
37%
2
- C3 -
-
3DO5
1
?
A:
[3-322]
-------
I
K
I
A
I
V
G
F
G
T
V
G
Q
G
V
A
E
L
L
I
R
K
-
R
E
E
I
E
K
A
I
G
-
E
F
K
V
T
A
V
----
A
D
S
K
-
S
S
I
S
G
DFS
L
V
E
A
L
R
M
K
R
----------
E
---
T
------------
G
M
--
L
----
R
D
D
A
K
A
I
-----------------
E
V
V
----
R
S
A
D
Y
D
V
L
I
E
ASVTR--------
E
G
----
V
N
----
Y
--
I
R
E
A
L
K
R
G
K
H
V
V
T
S
N
K
G
P
L
V
---
A
E
F
H
G
L
M
S
L
A
E
R
N
G
V
R
L
M
Y
E
A
T
V
G
G
A
M
P
V
V
K
L
A
K
R
Y
L
-
A
L
C
E
I
E
S
V
K
G
I
F
N
G
T
C
N
Y
I
L
S
R
M
E
E
E
---
R
L
P
Y
E
H
I
L
K
E
A
Q
E
L
G
Y
A
E
A
D
P
S
Y
D
V
E
G
I
D
A
A
L
K
L
V
I
I
A
N
T
-
I
G
V
K
A
S
Y
E
D
V
E
V
T
G
I
-----
T
Q
----------
I
T
P
------
E
A
F
Q
V
A
A
E
K
G
Y
T
----
I
R
L
I
A
E
V
S
R
E
----
K
L
K
--
V
S
P
-
R
L
V
P
F
H
H
P
L
A
-
I
K
G
T
M
N
A
A
M
F
K
T
D
T
A
G
-
S
I
F
V
A
G
R
G
A
G
K
E
E
T
A
S
A
I
L
S
D
L
Y
E
I
-------------------------------------------------------------------------------------------------------------------------
46
HHSearch
54.04
35%
-9
- C3 -
-
4YDR
-
?
B:
[1-303]
-------
M
K
L
L
L
F
G
Y
G
N
V
G
K
A
F
R
K
L
L
H
E
K
-
R
S
P
E
----
L
N
D
V
I
I
G
G
I
----
V
T
R
R
-
G
------------
I
M
L
Q
----------
D
KE-
D
------------
F
T
--
P
----
D
L
E
G
D
V
F
-----------------
K
A
F
----
E
K
I
K
P
D
I
I
V
D
-----
V
S
S
A
NYNN
G
E
----
P
S
----
L
S
L
Y
K
E
A
I
K
D
G
V
N
I
I
T
T
N
K
A
P
L
A
---
L
A
F
N
E
I
F
S
L
A
R
S
K
G
V
K
I
G
F
Q
G
T
V
M
S
G
T
P
S
I
N
L
Y
R
V
-
L
-
P
G
S
R
V
I
K
I
R
G
I
L
N
G
T
T
N
F
I
L
T
L
M
N
K
----
G
V
S
F
E
E
A
L
K
E
A
Q
R
R
G
Y
A
-
E
D
P
T
L
D
I
N
G
F
D
A
A
A
K
I
T
I
L
A
N
F
M
I
G
N
S
V
T
I
K
D
V
K
F
E
G
I
-----
N
R
----------
D
L
--------------
P
---
K
----
I
K
L
I
A
Y
A
D
E
----
K
E
V
W
--
V
K
P
-
L
P
I
S
Q
D
D
P
L
Y
N
V
D
G
V
E
N
A
L
E
I
T
T
D
I
-
Q
-
S
I
L
I
R
G
P
G
A
G
P
V
N
A
A
Y
G
A
L
S
D
L
I
L
L
K
R
D
C
---------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
53.90
34%
7
- C3 -
-
4YDR
-
?
A:
[1-302]
-------
M
K
L
L
L
F
G
Y
G
N
V
G
K
A
F
R
K
L
L
H
E
K
R
S
P
E
L
-----
N
D
V
I
I
G
G
I
----
V
T
R
R
-
G
I
M
LQDKE
D
F
---
T
P
D
L
----------
E
----------------------------
G
D
V
F
-----------------
K
A
F
----
E
K
I
K
P
D
I
I
V
D
-----
V
S
S
A
----
N
Y
NNGE
P
S
----
L
S
L
Y
K
E
A
I
K
D
G
V
N
I
I
T
T
N
K
A
P
L
A
---
L
A
F
N
E
I
F
S
L
A
R
S
K
G
V
K
I
G
F
Q
G
T
V
M
S
G
T
P
S
I
N
L
Y
R
V
-
L
-
P
G
S
R
V
I
K
I
R
G
I
L
N
G
T
T
N
F
I
L
T
L
M
-
N
K
---
G
V
S
F
E
E
A
L
K
E
A
Q
R
R
G
Y
A
E
E
D
P
T
L
D
I
N
G
F
D
A
A
A
K
I
T
I
L
A
N
F
M
I
G
N
S
V
T
I
K
D
V
K
F
E
G
I
-----
N
R
--------------------
D
L
P
K
N
E
K
I
K
L
----------
I
A
Y
A
D
E
K
--
E
V
W
--
V
K
P
-
L
P
I
S
Q
D
D
P
L
Y
N
V
D
G
V
E
N
A
L
E
I
T
T
D
-
I
Q
-
S
I
L
I
R
G
P
G
A
G
P
V
N
A
A
Y
G
A
L
S
D
L
I
L
L
K
R
D
----------------------------------------------------------------------------------------------------------------------
47
HHSearch
53.40
35%
-1
- C3 -
-
4YDR
-
?
A:
[1-303]
-------
M
K
L
L
L
F
G
Y
G
N
V
G
K
A
F
R
K
L
L
H
E
K
-
R
S
P
E
----
L
N
D
V
I
I
G
G
I
----
V
T
R
R
-
G
------------
I
M
L
Q
----------
D
KE-
D
------------
F
T
--
P
----
D
L
E
G
D
V
F
-----------------
K
A
F
----
E
K
I
K
P
D
I
I
V
D
-----
V
S
S
A
NYNN
G
E
----
P
S
----
L
S
L
Y
K
E
A
I
K
D
G
V
N
I
I
T
T
N
K
A
P
L
A
---
L
A
F
N
E
I
F
S
L
A
R
S
K
G
V
K
I
G
F
Q
G
T
V
M
S
G
T
P
S
I
N
L
Y
R
V
-
L
-
P
G
S
R
V
I
K
I
R
G
I
L
N
G
T
T
N
F
I
L
T
L
M
N
K
----
G
V
S
F
E
E
A
L
K
E
A
Q
R
R
G
Y
A
E
E
D
P
T
L
D
I
N
G
F
D
A
A
A
K
I
T
I
L
A
N
F
M
I
G
N
S
V
T
I
K
D
V
K
F
E
G
I
-----
N
R
----------
D
L
--------------
P
K
N
E
K
----
I
K
L
I
A
Y
A
D
E
----
K
E
V
W
--
V
K
P
-
L
P
I
S
Q
D
D
P
L
Y
N
V
D
G
V
E
N
A
L
E
I
T
T
D
I
-
Q
-
S
I
L
I
R
G
P
G
A
G
P
V
N
A
A
Y
G
A
L
S
D
L
I
L
L
K
R
D
C
---------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
52.49
34%
8
- C3 -
-
5AVO
-
?
A:
[1-302]
-------
M
K
L
L
L
F
G
Y
G
N
V
G
K
A
F
R
K
L
L
H
E
K
R
S
P
E
L
-----
N
D
V
I
I
G
G
I
----
V
T
R
R
-
G
I
M
LQDKE
D
F
---
T
P
D
L
----------
E
----------------------------
G
D
V
F
-----------------
K
A
F
----
E
K
I
K
P
D
I
I
V
D
-----
V
S
S
A
----
N
Y
NNGE
P
S
----
L
S
L
Y
K
E
A
I
K
D
G
V
N
I
I
T
T
N
K
A
P
L
A
---
L
A
F
N
E
I
F
S
L
A
R
S
K
G
V
K
I
G
F
Q
G
T
V
M
S
G
T
P
S
I
N
L
Y
R
V
-
L
-
P
G
S
R
V
I
K
I
R
G
I
L
N
G
T
T
N
F
I
L
T
L
M
-
N
K
---
G
V
S
F
E
E
A
L
K
E
A
Q
R
R
G
Y
-----
T
L
D
I
N
G
F
D
A
A
A
K
I
T
I
L
A
N
F
M
I
G
N
S
V
T
I
K
D
V
K
F
E
G
I
-----
N
R
--------------------
D
L
P
K
N
E
K
I
K
L
----------
I
A
Y
A
D
E
K
--
E
V
W
--
V
K
P
-
L
P
I
S
Q
D
D
P
L
Y
N
V
D
G
V
E
N
A
L
E
I
T
T
D
-
I
Q
-
S
I
L
I
R
G
P
G
A
G
P
V
N
A
A
Y
G
A
L
S
D
L
I
L
L
K
R
D
----------------------------------------------------------------------------------------------------------------------
43
HHSearch
49.71
27%
8
- C3 -
-
3C8M
-
?
A:
[4-328]
----
M
K
T
I
N
L
S
I
F
G
L
G
N
V
G
L
N
L
L
R
I
I
R
S
F
-
N
E
E
--
N
R
L
G
L
K
F
N
V
V
F
V
----
A
D
S
L
-
H
------------
S
Y
Y
N
----------
E
RID
I
G
K
V
I
S
Y
K
E
K
---
G
S
--
L
DSLE
Y
E
S
I
S
A
S
-----------------
E
A
L
----
A
-
R
D
F
D
I
V
V
D
-----
A
T
P
A
-----
S
----
A
D
G
K
K
E
L
A
F
Y
K
E
T
F
E
N
G
K
D
V
V
T
A
N
K
S
G
L
A
---
N
F
W
P
E
I
M
E
Y
A
R
S
N
N
R
R
I
R
Y
E
A
T
V
A
G
G
V
P
L
F
S
F
I
D
Y
S
V
-
L
P
S
R
I
K
K
F
R
G
I
V
S
L
T
I
N
Y
F
I
R
E
L
A
N
----
K
R
E
F
D
D
V
L
S
E
A
T
K
L
G
I
V
E
K
N
Y
K
D
D
L
T
G
L
D
A
A
R
K
S
V
I
L
C
N
H
L
Y
G
S
S
Y
R
L
S
D
V
F
Y
E
G
I
-----
L
-----------
Q
-------------
D
R
S
F
G
K
N
----
E
R
L
V
T
E
T
G
I
V
N
G
K
P
S
A
E
--
S
R
I
-
K
S
L
D
S
N
D
Y
L
L
T
L
G
K
G
S
L
G
Y
Q
L
Q
T
D
T
N
G
-
T
L
N
V
S
D
L
Y
D
G
P
Y
E
T
A
G
A
V
M
N
D
L
V
I
L
S
M
-----------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
48.91
31%
19
- C3 -
-
4XB1
3
?
A:
[19-325]
-------
V
N
I
S
I
F
G
F
G
T
V
G
----
R
A
L
A
E
I
-
I
A
E
K
S
R
I
F
G
V
E
L
N
V
I
S
I
T
D
RS
G
T
I
W
-
G
------------
D
F
D
L
L
---------
E
---
A
------------
K
E
--
V
----
K
E
S
T
G
K
L
SNIGD
Y
E
V
Y
NFS
P
Q
---
E
L
V
----
E
E
V
K
P
N
I
L
V
D
-----
V
-
S
S
----
W
D
----
E
A
----
H
E
M
Y
K
V
A
L
G
E
G
I
S
V
V
T
S
N
K
P
P
I
A
---
N
Y
Y
D
E
L
M
N
L
A
K
E
N
N
A
G
I
F
F
E
S
T
V
M
A
G
T
P
I
I
G
V
L
R
E
N
L
-
L
G
E
N
I
K
R
I
D
A
V
V
N
A
S
T
T
F
I
L
T
K
M
S
E
----
G
K
T
L
D
D
A
I
E
E
A
K
S
L
G
I
L
E
E
D
P
S
K
D
I
D
G
I
D
A
Y
Y
K
A
K
I
L
H
W
V
S
Y
G
E
P
P
E
E
E
---------------------------------------
E
R
L
G
I
R
EVRD
A
R
N
V
R
L
V
A
Q
V
S
K
G
-
K
I
S
--
V
K
P
R
K
L
S
S
D
N
P
L
L
--
V
E
G
V
Q
N
A
A
V
I
R
T
N
N
L
G
-
E
V
I
L
K
G
P
G
G
G
G
R
V
T
A
S
G
V
F
T
D
I
I
---------------------------------------------------------------------------------------------------------------------------
49
HHSearch
48.65
25%
-6
- C3 -
-
1EBU
2
DHOM_YEAST
D:
[1-357]
---
S
T
K
V
V
N
V
A
V
I
G
A
G
V
V
G
S
A
F
L
D
Q
L
L
A
M
-
K
S
T
------
I
T
Y
N
L
V
L
L
----
A
E
A
E
-
R
------------
S
L
I
S
KDFSPLNVGS
D
---
W
KAA---------
L
A
AS
T
----
T
K
T
L
P
L
D
-----------------
D
L
I
AHLK
T
S
P
K
P
V
I
L
V
D
-----
N
T
S
S
-----
A
----
Y
I
----
A
G
F
Y
T
K
F
V
E
N
G
I
S
I
A
T
P
N
K
K
A
F
S
SDL
A
T
W
K
A
L
F
S
N
K
-
P
T
N
G
F
V
Y
H
E
A
T
V
G
A
G
L
P
I
I
S
F
L
R
E
I
I
Q
T
G
D
E
V
E
K
I
E
G
I
F
S
G
T
L
S
Y
I
F
N
E
F
S
T
S
QAN
D
V
K
F
S
D
V
V
K
V
A
K
K
L
G
Y
T
E
P
D
P
R
D
D
L
N
G
L
D
V
A
R
K
V
T
I
V
G
R
I
S
G
V
E
V
E
S
P
T
S
F
P
V
Q
S
L
IPKPL
E
S
VKSADEFLEK
L
S
D
YDKDLT
Q
L
K
K
E
A
A
T
E
N
K
V
----
L
R
F
I
G
K
V
D
V
A
--
T
K
S
V
S
--
V
G
I
-
E
K
Y
D
Y
S
H
P
F
A
S
L
K
G
S
D
N
V
I
S
I
K
T
K
R
Y
T
N
P
V
V
I
Q
G
A
G
A
G
A
A
V
T
A
A
G
V
L
G
D
V
I
K
I
A
Q
R
----------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
48.62
30%
19
- C3 -
-
4XB2
2
?
A:
[19-325]
-------
V
N
I
S
I
F
G
F
G
T
V
G
----
R
A
L
A
E
I
-
I
A
E
K
S
R
I
F
G
V
E
L
N
V
I
S
I
----
T
D
R
S
-
G
T
I
----------
W
G
D
F
----------
D
---
L
------------
L
E
--
A
----
K
E
V
A
E
S
T
GKLSNIGD
Y
E
V
Y
NFS
P
Q
E
L
V
----
E
E
V
K
P
N
I
L
V
D
-----
V
-
S
S
----
W
D
----
E
A
----
H
E
M
Y
K
V
A
L
G
E
G
I
S
V
V
T
S
N
K
P
P
I
A
---
N
Y
Y
D
E
L
M
N
L
A
K
E
N
N
A
G
I
F
F
E
S
T
V
M
A
G
T
P
I
I
G
V
L
R
E
N
L
-
L
G
E
N
I
K
R
I
D
A
V
V
N
A
S
T
T
F
I
L
T
K
M
S
E
----
G
K
T
L
D
D
A
I
E
E
A
K
S
L
G
I
L
E
E
D
P
S
K
D
I
D
G
I
D
A
Y
Y
K
A
K
I
L
H
W
V
S
Y
G
E
P
P
E
E
E
---------------------------------------
E
R
L
G
I
R
EVRD
A
R
N
V
R
L
V
A
Q
V
S
K
G
-
K
I
S
--
V
K
P
R
K
L
S
S
D
N
P
L
L
--
V
E
G
V
Q
N
A
A
V
I
R
T
N
N
L
G
-
E
V
I
L
K
G
P
G
G
G
G
R
V
T
A
S
G
V
F
T
D
I
I
---------------------------------------------------------------------------------------------------------------------------