@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMM2: (2017-11-09 )
MKLLRLNALSPNFQLPQTAVTIGNFDGVHLGHQAMIAQLKKIAAAQGLKTLVMIFEPQPLEFFKGYDAPPRINSLREKVEYLAELGVDYIAVAKFDQHFRSMSASEFADLLKDKLNAQALVLGDDFHFGKDRQGNSEFLKNYGFQVTNLHTIELEGERVSSTRIRQVLQVGNLALAAKLLGRPYSITGRVQYGDQIGRTLDFPTINVRLNRHKPCLNGIYGVEVICETTSLTQKVLQDNPEKPGIAGYHENSLYGAGHVGTRPAIQQEHPEWRLEVHFPDVSANLYGLFMRVTFLHYLHGELNYPSLEALKAGIDNDVQQLRQYRNDTTQFPF
Atome Classification :
(22 SA)
.........10........20........30........40........50........60.......--.70........80........90........100......-.-110.......120.......130.......140.---......150..---.....160.......170.......180.......190.-....-..200.......-210..--...--...220.......230.......240.......250.......260......-.270.......280.......290.......300.......310.......320.......330.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
L
L
R
LNALSPNFQLP
Q
T
A
V
T
IGNFDGVHL
G
H
Q
A
M
I
A
Q
L
K
K
I
A
A
A
QG
L
K
T
L
V
M
I
FEPQ
P
L
E
F
F
KGYDA--PP
R
I
N
S
L
R
E
K
V
E
Y
L
A
E
LGV
D
Y
I
A
V
A
K
F
D
Q
H
F
R
SM
S
A
S
E
F
A
-
D
-
L
L
K
D
KLNA
Q
A
L
V
L
GDDFHFGKDRQG
N
S
E
F
L
K
NYG---
F
Q
V
T
N
L
H
T
I
E
L---EGERV
S
S
T
R
I
R
Q
V
L
Q
VG
N
L
A
L
A
A
K
L
LGRPY
S
I
T
G
R
V
Q
YG-DQIG-RTLDF
P
T
I
N
V
R
L-NR-HK--
P
C
L--NGIY
G
V
E
V
I
CE
T
T
S
L
T
Q
K
V
L
QDNPEKPGIAGYHENSLYGAGHVGTRPAIQQE-HP
E
W
R
L
E
V
HFPDVS
A
N
L
Y
G
L
F
M
R
V
T
F
L
H
Y
L
HGELNYP
S
L
E
A
L
K
AGI
D
N
D
V
Q
Q
L
R
Q
YRNDTTQFPF
40
HHSearch
88.23
32%
-111
- C3 -
-
1S4M
1
?
A:
[1-285]
-----------------
M
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
-
L
P
-
D
F
--
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
--
A
R
T
V
V
L
D
F
F
-
R
I
K
D
L
T
P
E
G
F
V
-
E
-
R
Y
L
S
--
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
---
V
E
V
Y
E
I
E
D
V
V
V
---
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
H
K
-----------
F
P
T
A
N
I
D
R
G
N
E
K
L
V
--
D
L
K
--
R
G
V
Y
L
V
R
V
H
L
P
D
G
---------------------
K
K
K
F
G
V
M
N
V
G
F
R
P
T
--
D
A
R
N
V
--
K
Y
E
V
Y
I
L
D
F
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
----
39
HHSearch
87.26
32%
-122
- C3 -
-
1MRZ
2
?
B:
[2-285]
------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
-
L
P
-
D
F
--
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
--
A
R
T
V
V
L
D
F
F
-
R
I
K
D
L
T
P
E
G
F
V
-
E
-
R
Y
L
S
--
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
---
V
E
V
Y
E
I
E
D
V
V
V
---
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
H
------------
F
P
T
A
N
I
D
R
G
N
E
K
L
V
--
D
L
K
--
R
G
V
Y
L
V
R
V
H
L
P
D
G
---------------------
K
K
K
F
G
V
M
N
V
G
F
--------
N
V
--
K
Y
E
V
Y
I
L
D
F
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
----
28
Fugue
86.77
31%
-110
- C3 -
-
1MRZ
1
?
A:
[2-288]
------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
P
--
D
F
--
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
A
R
T
V
V
L
D
---
F
F
R
I
K
D
L
T
P
E
G
F
V
-
E
-
R
Y
L
--
S
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
---
V
E
V
Y
E
I
E
D
V
V
V
---
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
R
-
G
N
-
E
K
--
L
V
D
L
K
R
G
V
Y
L
V
R
V
H
----------
L
P
D
G
K
K
K
F
G
V
M
N
V
G
F
R
-------------------
R
N
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
E
E
----
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
N
S
K
-
6
PsiBlast_PDB
84.69
29%
-104
- C3 -
-
1S4M
1
?
A:
[2-288]
------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
P
--
D
F
--
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
----
Y
A
R
T
V
V
L
D
-
F
F
R
I
K
D
L
T
P
E
G
-
F
-
V
E
R
Y
L
S
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
---
V
E
V
Y
E
I
E
D
V
V
V
---
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
H
K
-----------
F
P
T
A
N
I
D
R
-
G
N
-
E
K
L
V
D
L
K
--
R
G
V
Y
L
V
R
V
H
----------
L
P
D
G
K
K
K
-----------
F
G
V
M
N
V
G
F
R
P
T
--
D
A
-
R
-
N
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
N
S
K
-
2
PsiBlast_PDB
84.43
29%
-104
- C3 -
-
1MRZ
1
?
A:
[2-288]
------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
P
--
D
F
--
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
----
Y
A
R
T
V
V
L
D
-
F
F
R
I
K
D
L
T
P
E
G
-
F
-
V
E
R
Y
L
S
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
---
V
E
V
Y
E
I
E
D
V
V
V
---
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
R
-
G
N
-
E
K
L
V
D
L
K
--
R
G
V
Y
L
V
R
V
H
----------
L
P
D
G
K
K
K
-----------
F
G
V
M
N
V
G
F
R
-------
R
-
N
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
N
S
K
-
12
PsiBlast_PDB
83.41
29%
-99
- C3 -
-
2I1L
-
?
A:
[2-289]
------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
P
--
D
F
--
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
----
Y
A
R
T
V
V
L
D
-
F
F
R
I
K
D
L
T
P
E
G
-
F
-
V
E
R
Y
L
S
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
---
V
E
V
Y
E
I
E
D
V
V
V
---
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
R
-
G
N
-
E
K
L
V
D
L
K
--
R
G
V
Y
L
V
R
V
H
----------
L
P
D
G
K
K
K
-----------
F
G
V
M
N
V
G
F
R
---------
N
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
N
S
K
F
3
PsiBlast_PDB
83.05
29%
-101
- C3 -
-
1T6X
1
?
A:
[2-288]
------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
P
--
D
F
--
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
----
Y
A
R
T
V
V
L
D
-
F
F
R
I
K
D
L
T
P
E
G
-
F
-
V
E
R
Y
L
S
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
---
V
E
V
Y
E
I
E
D
V
V
V
---
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
R
-
G
N
-
E
K
L
V
D
L
K
--
R
G
V
Y
L
V
R
V
H
----------
L
P
D
G
K
K
K
-----------
F
G
V
M
N
V
G
F
R
-------
R
-
N
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
N
S
K
-
5
PsiBlast_PDB
82.23
29%
-100
- C3 -
-
1T6Z
1
?
A:
[2-288]
------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
P
--
D
F
--
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
----
Y
A
R
T
V
V
L
D
-
F
F
R
I
K
D
L
T
P
E
G
-
F
-
V
E
R
Y
L
S
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
---
V
E
V
Y
E
I
E
D
V
V
V
---
Q
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
R
-
G
N
-
E
K
L
V
D
L
K
--
R
G
V
Y
L
V
R
V
H
----------
L
P
D
G
K
K
K
-----------
F
G
V
M
N
V
G
F
R
-------
R
-
N
V
K
Y
E
V
Y
I
L
D
F
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
I
I
N
S
K
-
38
HHSearch
81.56
31%
-27
* C3 *
-
5FO1
1
RIBF_CORAM
A:
[12-323]
------------
K
D
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
--
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
E
F
-
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
QSR
L
T
V
D
V
I
D
L
L
D
D
---
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
-
A
G
R
G
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
T
-
V
A
--
L
P
A
--
D
G
V
Y
A
G
W
L
T
I
L
P
T
-
E
A
------
P
V
---
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
-
Q
R
--
S
V
E
S
F
V
L
D
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
A
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
D
V
Q
---
26
PsiBlast_CBE
81.10
31%
-23
- C3 -
-
5FNZ
1
RIBF_CORAM
B:
[14-315]
--------------
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
--
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
---
Q
S
R
L
T
V
D
V
I
D
L
LDD
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
---
E
L
G
W
P
T
A
N
Q
Y
F
----
H
D
--
T
V
A
--
L
P
A
D
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
V
S
G
N
M
E
P
-------
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
----
Q
R
S
--
V
E
S
F
V
L
D
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
-----------
7
PsiBlast_PDB
81.09
31%
-19
- C3 -
-
5FO0
1
RIBF_CORAM
A:
[14-315]
--------------
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
--
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
---
Q
S
R
L
T
V
D
V
I
D
L
LDD
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
-
K
E
L
G
F
P
T
A
N
Q
Y
F
----
H
D
--
T
V
A
--
L
P
A
D
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
V
S
G
N
M
E
P
-------
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
----
E
---
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
E
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
-----------
13
PsiBlast_PDB
81.07
31%
-19
- C3 -
-
5FO1
1
RIBF_CORAM
A:
[14-315]
--------------
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
--
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
---
Q
S
R
L
T
V
D
V
I
D
L
LDD
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
-
K
E
L
G
F
P
T
A
N
Q
Y
F
----
H
D
--
T
V
A
--
L
P
A
D
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
V
S
G
N
M
E
P
-------
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
---
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
A
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
-----------
27
PsiBlast_CBE
81.04
31%
-17
- C3 -
-
5FO1
1
RIBF_CORAM
B:
[14-315]
--------------
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
--
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
---
Q
S
R
L
T
V
D
V
I
D
L
LDD
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
-
K
E
L
G
F
P
T
A
N
Q
Y
F
----
H
D
--
T
V
A
--
L
P
A
D
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
V
S
G
N
M
E
P
-------
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
---
E
---
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
A
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
-----------
24
PsiBlast_CBE
81.00
31%
-17
- C3 -
-
4UZE
1
RIBF_CORAM
B:
[14-315]
--------------
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
A
A
--
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
---
Q
S
R
L
T
V
D
V
I
D
L
LDD
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
-
K
E
L
G
F
P
T
A
N
Q
Y
F
----
H
D
--
T
V
A
--
L
P
A
D
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
V
S
G
N
M
E
P
-------
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
---
E
---
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
-----------
1
PsiBlast_PDB
80.63
31%
-17
- C3 -
-
4UZF
1
RIBF_CORAM
A:
[14-315]
--------------
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
E
A
--
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
---
Q
S
R
L
T
V
D
V
I
D
L
LDD
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
-
K
E
L
G
F
P
T
A
N
Q
Y
F
----
H
D
--
T
V
A
--
L
P
A
D
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
V
S
G
N
M
E
P
-------
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
----
E
---
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
-----------
9
PsiBlast_PDB
80.38
31%
-19
- C3 -
-
4UZE
1
RIBF_CORAM
A:
[14-315]
--------------
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
A
A
--
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
---
Q
S
R
L
T
V
D
V
I
D
L
LDD
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
-
K
E
L
G
F
P
T
A
N
Q
Y
F
----
H
D
--
T
V
A
--
L
P
A
D
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
V
S
G
N
M
E
P
-------
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
---
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
-----------
23
PsiBlast_CBE
79.92
31%
-20
- C3 -
-
2X0K
1
RIBF_CORAM
B:
[14-315]
--------------
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
--
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
---
Q
S
R
L
T
V
D
V
I
D
L
LDD
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
-
K
E
L
G
F
P
T
A
N
Q
Y
F
----
H
D
--
T
V
A
--
L
P
A
D
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
V
S
G
N
M
E
P
-------
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
---
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
-----------
8
PsiBlast_PDB
79.80
31%
-19
- C3 -
-
2X0K
1
RIBF_CORAM
A:
[14-315]
--------------
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
--
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
---
Q
S
R
L
T
V
D
V
I
D
L
LDD
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
-
K
E
L
G
F
P
T
A
N
Q
Y
F
----
H
D
--
T
V
A
--
L
P
A
D
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
V
S
G
N
M
E
P
-------
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
---
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
-----------
22
PsiBlast_CBE
79.75
31%
-17
- C3 -
-
5FO0
1
RIBF_CORAM
B:
[14-315]
--------------
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
--
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
---
Q
S
R
L
T
V
D
V
I
D
L
LDD
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
-
K
E
L
G
F
P
T
A
N
Q
Y
F
----
H
D
--
T
V
A
--
L
P
A
D
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
V
S
G
N
M
E
P
-------
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
----
E
---
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
E
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
-----------
36
HHSearch
79.68
31%
-23
- C3 -
-
3OP1
8
?
A:
[16-307]
-----------
I
G
T
P
S
D
S
V
V
V
L
G
Y
F
D
G
I
H
K
G
H
Q
E
L
F
R
V
A
N
K
A
A
R
K
D
L
L
P
I
V
V
M
T
F
N
E
S
P
K
I
A
L
E
P
Y
H
P
DL
F
L
H
I
L
N
P
A
E
R
E
R
K
L
K
R
E
G
V
E
E
L
Y
L
L
D
F
S
S
Q
F
A
S
L
T
A
Q
E
F
F
-
A
-
T
Y
I
K
A
M
N
A
K
I
I
V
A
G
F
D
Y
T
F
G
S
D
K
K
-
T
A
E
D
L
K
N
Y
F
D--
G
E
V
I
I
V
P
P
V
E
D
---
E
K
G
K
I
S
S
T
R
I
R
Q
A
I
L
D
G
N
V
K
E
A
G
K
L
L
G
A
P
L
P
S
R
G
M
V
V
H
G
-
N
-------
G
Y
P
T
A
N
L
V
L
L
D
R
-
T
Y
--
M
P
A
--
D
G
V
Y
V
V
D
V
E
I
Q
-
R
---------------------
Q
K
Y
R
A
M
A
S
V
G
K
N
V
T
F
D
---
E
A
--
R
F
E
V
N
I
F
D
F
N
Q
D
I
Y
G
E
T
V
M
V
Y
W
L
D
R
I
R
D
M
T
K
F
D
S
V
D
Q
L
V
D
Q
L
K
A
D
E
E
V
T
R
N
W
---------
21
PsiBlast_CBE
79.62
31%
-18
- C3 -
-
4UZF
1
RIBF_CORAM
B:
[14-315]
--------------
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
E
A
--
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
---
Q
S
R
L
T
V
D
V
I
D
L
LDD
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
-
K
E
L
G
F
P
T
A
N
Q
Y
F
----
H
D
--
T
V
A
--
L
P
A
D
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
V
S
G
N
M
E
P
-------
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
---
E
---
Q
R
S
V
E
S
F
V
L
D
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
-----------
11
PsiBlast_PDB
78.45
31%
-25
- C3 -
-
5FNZ
1
RIBF_CORAM
A:
[14-315]
--------------
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
A
--
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
T
S
P
E
K
Y
V
-
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
---
Q
S
R
L
T
V
D
V
I
D
L
LDD
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
------
W
P
T
A
N
Q
Y
F
----
H
D
--
T
V
A
--
L
P
A
D
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
V
S
G
N
M
E
P
-------
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
------
Q
R
S
--
V
E
S
F
V
L
D
R
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
-----------