@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMQ7: (2017-11-09 )
MQIAKLKIAIIGLGYVGLPLAVEFGKKVPVVGFDIYQKRIDELKNGQDHTLEVSPEELKQAVHLKYTAHLDDLQDSNFFIVTVPTPIDDFKQPDLTPLIKASTSIGQVLKKGDVVVYESTVYPGATEEVCIPVLEKISGLKFNQDFFAGYSPERINPGDKQHRVTNILKITSGSTPEVADYIDEVYNLIIEAGTHKAPNIKVAEAAKVIENTQRDVNIALINELALIFNKLDIDTEDVLKAAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQSIGLHPEIILAARRLNDRMGEHVATQLIKEMVKQRIQVVGARILVMGLSFKENCPDIRNTKIVDFIKALKEYDLDLDIYDPWVDDTEVQHEYGLAPIKELQQGLYDAIVIAVAHNQFKSMSVEEFHALGKEKHVLYDLKYVLDKESSNIRL
Atome Classification :
(20 SA)
.........10........---20...---..---.--.---.30......----.----.40......----..50-.....--.---.-.----.60-.---.---..---.....-70-..---......80........--90----.--........100.......110-.........120......-.130.......140.......150.......160.......170..-----.-.-.-----.----..180---......-.190.-......200--.........210.......220.......230......------.240.--.----.--.----...250------.....-....260.......270-.----....----.---.--280--......--...290.......300.......310-.......320.......330.......340-....-...350.......360.---------------.-------------.--....370-------.....------..380....--.....390.......400..---...-...410.......420..------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
Q
I
A
K
L
K
I
A
I
I
G
LGYVGL
P
---
L
A
V
EF---GK---K--V---PVV
G
F
D
I
Y
Q
----
K
----
R
I
D
E
L
KNGQ----D
H
T
--
L
EV
S
P
--
E
---
E
-
L
----
K
Q
--
A
---
V
---
H
L
---
K
Y
T
A
H-LD-DL---QDS
N
F
F
I
V
TVPTPIDD--F-----K--QPDL
T
P
L
I
KA
S
T
S
I
G
Q
V
L
K---KG
D
V
V
V
Y
ESTVYPGA
T
E
E
-
V
C
I
P
V
L
E
K
I
SGLKF
N
Q
D
F
FAGYSPERINPG
D
K
Q
H
R
V
T
N
I
L
K
IT-SG-----S-T-
P
-----
E
----
V
A
D
Y
I
---
D
E
V
Y
N
L
-
I
I
EAG-THKAPNI----
K
V
A
E
A
A
K
V
I
E
NTQRD
V
N
I
A
L
I
N
E
L
A
L
I
F
N
KLDI
D
T
E
D
V
------
L
K
AAG--T----K--W----NFLP--------FRPGL-VGG
H
C
IGVD
P
Y
Y
L
T
HKA-Q----SIGL----
H
---
P
--
E
----
I
I
L
A
A
R
--
R
L
N
D
R
M
G
E
H
V
A
T
Q
L
I
K
E
M
V
K
Q
R
I
Q
V
V
-
G
A
R
I
L
V
M
GLSFKENCPDIRN
T
K
I
V
D
F
I
K
A
L
-
K
EYD-LD
L
D
IYDPWVDDT
E
V
Q
H
---------------E-------------Y--GLA
P
I
K
E
-------
L
Q
Q
G
L
------
Y
D
A
--
I
V
I
A
--
V
AHNQFKSM
S
V
E
E
F
H
A
-LGK---E
K
H
-
V
L
Y
D
L
K
Y
V
LDKESSNIRL------------
4
PsiBlast_PDB
80.80
29%
1
- C1 -
-
4XR9
2
?
A:
[16-431]
-----
L
K
V
V
I
A
G
A
G
Y
V
G
T
C
---
L
A
V
T
L
A
--
G
R
---
G
--
A
---
E
V
V
A
V
D
S
D
P
----
G
----
T
V
A
D
L
R
A
G
R
CRLP
E
P
G
--
L
A
G
A
V
--
R
---
D
-
L
----
A
A
--
T
---
G
---
R
L
---
T
A
S
T
S
-
Y
D
-
P
V
---
G
A
A
D
V
V
I
V
T
V
G
T
P
T
D
A
--
G
-----
H
--
E
M
V
T
D
Q
L
V
A
A
C
E
Q
I
A
P
R
L
R
---
A
G
Q
L
V
I
L
K
S
T
V
S
P
G
T
T
R
T
-
L
V
A
P
L
L
E
S
-
G
G
L
V
H
E
R
D
F
G
L
A
F
C
P
E
R
L
A
E
G
V
A
L
A
Q
V
R
T
L
P
V
V
V
-
G
G
-----
C
-
G
-
P
-----
R
----
S
A
A
A
A
---
E
R
F
W
R
S
-
A
L
G
V
D
-
V
R
Q
V
P
S
A
----
E
S
A
E
V
V
K
L
A
T
N
W
W
I
D
A
N
V
A
I
A
N
E
L
A
R
Y
C
A
V
L
G
V
D
V
L
D
V
------
I
G
A
A
----------------
N
T
L
P
KGSSMVNL
L
L
P
G
V
G
V
G
G
S
C
L
T
K
D
P
W
M
A
W
R
D
G
-
R
----
D
R
G
V
----
S
---
L
--
R
----
T
V
E
T
A
R
--
A
V
N
D
D
M
P
R
H
T
A
A
V
I
A
D
E
L
V
K
L
G
R
D
R
N
-
D
T
T
I
A
V
L
G
A
A
F
K
N
D
T
G
D
V
R
N
T
P
V
R
G
V
V
A
A
L
-
R
D
S
G
-
F
R
V
R
I
F
D
P
L
A
D
P
A
E
I
V
A
---------------
R
-------------
F
--
G
T
A
P
A
A
S
-------
L
D
E
A
V
------
S
G
A
--
G
C
L
A
FL
A
G
H
R
Q
F
H
E
L
---
D
F
G
A
-
L
A
E
R
VD
E
P
C
-
L
V
F
D
--------------------------
5
PsiBlast_PDB
78.72
29%
7
- C1 -
-
4XRR
1
?
A:
[16-431]
-----
L
K
V
V
I
A
G
A
G
Y
V
G
T
C
---
L
A
V
T
L
A
--
G
R
---
G
--
A
---
E
V
V
A
V
D
S
D
P
----
G
----
T
V
A
D
L
R
A
G
R
CRLP
E
P
G
--
L
A
G
A
V
--
R
---
D
-
L
----
A
A
--
T
---
G
---
R
L
---
T
A
S
T
S
-
Y
D
-
P
V
---
G
A
A
D
V
V
I
V
T
V
G
T
P
T
D
A
--
G
-----
H
--
E
M
V
T
D
Q
L
V
A
A
C
E
Q
I
A
P
R
L
R
---
A
G
Q
L
V
I
L
K
S
T
V
S
P
G
T
T
R
T
-
L
V
A
P
L
L
E
S
-
G
G
L
V
H
E
R
D
F
G
L
A
F
C
P
E
R
L
A
E
G
V
A
L
A
Q
V
R
T
L
P
V
V
V
-
G
G
-----
C
-
G
-
P
-----
R
----
S
A
A
A
A
---
E
R
F
W
R
S
-
A
L
G
V
D
-
V
R
Q
V
P
S
A
----
E
S
A
E
V
V
K
L
A
T
N
W
W
I
D
A
N
V
A
I
A
N
E
L
A
R
Y
C
A
V
L
G
V
D
V
L
D
V
------
I
G
A
A
----------------
N
T
L
P
KGSSMV
N
L
L
L
P
G
V
G
V
G
G
S
C
L
T
K
D
P
W
M
A
W
R
D
G
-
R
----
D
R
G
V
----
S
---
L
--
R
----
T
V
E
T
A
R
--
A
V
N
D
D
M
P
R
H
T
A
A
V
I
A
D
E
L
V
K
L
G
R
D
R
N
-
D
T
T
I
A
V
L
G
A
A
F
K
N
D
T
G
D
V
R
N
T
P
V
R
G
V
V
A
A
L
-
R
D
S
G
-
F
R
V
R
I
F
D
P
L
A
D
P
A
E
I
V
A
---------------
R
-------------
F
--
G
T
A
P
A
A
S
-------
L
D
E
A
V
------
S
G
A
--
G
C
L
A
FL
A
G
H
R
Q
F
H
E
L
---
D
F
G
A
-
L
A
E
R
VD
E
P
C
-
L
V
F
D
--------------------------
29
HHSearch
78.51
32%
8
- C1 -
-
3OJO
7
?
B:
[12-416]
-----
S
K
L
T
V
V
G
L
G
Y
I
G
L
P
---
T
S
I
M
F
---
A
K
---
H
G-
V
---
D
V
L
G
V
D
I
N
Q
----
Q
----
T
I
D
K
L
Q
N
G
Q
----
I
S
I
--
E
E
P
G
L
--
Q
---
E
V
Y
----
E
E
--
V
---
L
S
S
G
K
L
---
K
V
S
T
T
-----
P
---
E
A
S
D
V
F
I
I
A
V
P
T
P
N
N
D
--
D
QY---
R
--
S
C
D
I
S
L
V
M
R
A
L
D
S
I
L
P
F
L
K
---
K
G
N
T
I
I
V
E
S
T
I
A
P
K
T
M
D
D
-
F
V
K
P
V
I
E
N
-
L
G
F
T
I
G
E
D
I
Y
L
V
H
C
P
E
R
V
L
P
G
K
I
L
E
E
L
V
H
N
N
R
I
I
-
G
G
-----
V
-
T
-
K
-----
A
----
C
I
E
A
G
---
K
R
V
Y
R
T
-
F
V
Q
G
--
E
M
I
E
T
D
A
----
R
T
A
E
M
S
K
L
M
E
N
T
Y
R
D
V
N
I
A
L
A
N
E
L
T
K
I
C
N
N
L
N
I
N
V
L
D
V
------
I
E
M
A
N
--
K
----
H
--
P
----
R
V
N
I
--------
H
Q
P
G
P
G
V
G
G
H
C
L
A
V
D
P
Y
F
I
I
A
K
D
-
P
----
E
-------
N
---
A
--
K
----
L
I
Q
T
G
R
--
E
I
N
N
S
M
P
A
Y
V
V
D
T
T
K
Q
I
I
K
----
A
L
S
-
G
N
K
V
T
V
F
G
L
T
Y
K
G
D
V
D
D
I
R
E
S
P
A
F
D
I
Y
E
L
L
-
N
Q
E
P
D
I
E
V
C
A
Y
D
P
H
V
E
L
D
F
V
-----------------------------------
E
H
D
-
M
S
-------
H
A
V
K
D
------
A
S
L
--
V
L
I
L
--
S
D
H
S
E
F
K
N
L
S
D
S
H
F
-
D
-
K
M
----
K
H
K
-
V
I
F
D
T
K
N
V
V
K
S
S
F
E
D
---------------
21
PsiBlast_CBE
77.38
32%
15
- C1 -
-
3OJO
7
?
B:
[13-410]
------
K
L
T
V
V
G
L
G
Y
I
G
L
P
---
T
S
I
M
F
---
A
K
---
H
G-
V
---
D
V
L
G
V
D
I
N
Q
----
Q
----
T
I
D
K
L
Q
N
G
Q
IS
I
E
E
P
G
--
L
Q
E
V
Y
--
E
---
E
-
V
----
L
S
--
S
---
G
---
K
L
---
K
V
S
T
-----
T
P
---
E
A
S
D
V
F
I
I
A
V
P
T
P
N
N
D
DQ
Y
-----
R
--
S
C
D
I
S
L
V
M
R
A
L
D
S
I
L
P
F
L
K
---
K
G
N
T
I
I
V
E
S
T
I
A
P
K
T
M
D
D
-
F
V
K
P
V
I
E
N
L
-
G
F
T
I
G
E
D
I
Y
L
V
H
C
P
E
R
V
L
P
G
K
I
L
E
E
L
V
H
N
N
R
I
I
-
G
G
-----
V
-
T
-
K
-----
A
----
C
I
E
A
G
---
K
R
V
Y
R
T
-
F
V
Q
-
G
-
E
M
I
E
T
D
A
----
R
T
A
E
M
S
K
L
M
E
N
T
Y
R
D
V
N
I
A
L
A
N
E
L
T
K
I
C
N
N
L
N
I
N
V
L
D
V
------
I
E
M
A
N
--
K
----
H
--
P
----
R
V
N
I
--------
H
Q
P
G
P
G
V
G
G
H
C
L
A
V
D
P
Y
F
I
I
A
K
D
-
P
----
E
-------
N
---
A
--
K
----
L
I
Q
T
G
R
--
E
I
N
N
S
M
P
A
Y
V
V
-----
D
T
T
K
Q
I
I
K
A
L
S
G
N
K
V
T
V
F
G
L
T
Y
K
G
D
V
D
D
I
R
E
S
P
A
F
D
I
Y
E
L
L
N
Q
E
P
D
-
I
E
V
C
A
Y
D
P
H
V
E
L
D
F
V
E
H
--------------------------------------
D
-------
M
S
H
A
V
------
K
D
A
S
L
V
L
I
L
--
S
D
H
S
E
F
K
N
L
S
D
S
H
F
D
----
K
---
M
K
H
K
V
I
F
D
T
K
N
V
V
---------------------
30
HHSearch
76.38
32%
1
- C1 -
-
3OJO
7
?
A:
[12-416]
-----
S
K
L
T
V
V
G
L
G
Y
I
G
L
P
---
T
S
I
M
F
---
A
K
---
H
G-
V
---
D
V
L
G
V
D
I
N
Q
----
Q
----
T
I
D
K
L
Q
N
G
Q
----
I
S
I
--
E
E
P
G
L
--
Q
---
E
V
Y
----
E
E
--
V
---
L
S
S
G
K
L
---
K
V
S
T
T
-----
P
---
E
A
S
D
V
F
I
I
A
V
P
T
P
N
N
D
--
D
QY---
R
--
S
C
D
I
S
L
V
M
R
A
L
D
S
I
L
P
F
L
K
---
K
G
N
T
I
I
V
E
S
T
I
A
P
K
T
M
D
D
-
F
V
K
P
V
I
E
N
-
L
G
F
T
I
G
E
D
I
Y
L
V
H
C
P
E
R
V
L
P
G
K
I
L
E
E
L
V
H
N
N
R
I
I
-
G
G
-----
V
-
T
-
K
-----
A
----
C
I
E
A
G
---
K
R
V
Y
R
T
-
F
V
Q
G
--
E
M
I
E
T
D
A
----
R
T
A
E
M
S
K
L
M
E
N
T
Y
R
D
V
N
I
A
L
A
N
E
L
T
K
I
C
N
N
L
N
I
N
V
L
D
V
------
I
E
M
A
N
--
K
----
H
--
P
----
R
V
N
I
--------
H
Q
P
G
P
G
V
G
G
H
C
L
A
V
D
P
---------------------
N
---
A
--
K
----
L
I
Q
T
G
R
--
E
I
N
N
S
M
P
A
Y
V
V
D
T
T
K
Q
I
I
K
----
A
L
S
-
G
N
K
V
T
V
F
G
L
T
Y
K
G
D
V
D
D
I
R
E
S
P
A
F
D
I
Y
E
L
L
-
N
Q
E
P
D
I
E
V
C
A
Y
D
P
H
V
E
L
D
F
V
-----------------------------------
E
H
D
-
M
S
-------
H
A
V
K
D
------
A
S
L
--
V
L
I
L
--
S
D
H
S
E
F
K
N
L
S
D
S
H
F
-
D
-
K
M
----
K
H
K
-
V
I
F
D
T
K
N
V
V
K
S
S
F
E
D
---------------
2
PsiBlast_PDB
75.65
32%
14
- C1 -
-
3OJL
1
?
A:
[13-410]
------
K
L
T
V
V
G
L
G
Y
I
G
L
P
---
T
S
I
M
F
---
A
K
---
H
G-
V
---
D
V
L
G
V
D
I
N
Q
----
Q
----
T
I
D
K
L
Q
N
G
Q
IS
I
E
E
P
G
--
L
Q
E
V
Y
--
E
---
E
-
V
----
L
S
--
S
---
G
---
K
L
---
K
V
S
T
-----
T
P
---
E
A
S
D
V
F
I
I
A
V
P
T
P
N
N
D
DQ
Y
-----
R
--
S
C
D
I
S
L
V
M
R
A
L
D
S
I
L
P
F
L
K
---
K
G
N
T
I
I
V
E
S
T
I
A
P
K
T
M
D
D
-
F
V
K
P
V
I
E
N
L
-
G
F
T
I
G
E
D
I
Y
L
V
H
C
P
E
R
V
L
P
G
K
I
L
E
E
L
V
H
N
N
R
I
I
-
G
G
-----
V
-
T
-
K
-----
A
----
C
I
E
A
G
---
K
R
V
Y
R
T
-
F
V
Q
-
G
-
E
M
I
E
T
D
A
----
R
T
A
E
M
S
K
L
M
E
N
T
Y
R
D
V
N
I
A
L
A
N
E
L
T
K
I
C
N
N
L
N
I
N
V
L
D
V
------
I
E
M
A
N
--
K
----
H
--
P
----
R
V
N
I
--------
H
Q
P
G
P
G
V
G
G
H
C
L
A
V
D
P
Y
F
I
I
A
K
D
-
P
----
E
-------
N
---
A
--
K
----
L
I
Q
T
G
R
--
E
I
N
N
S
M
P
A
Y
V
V
-----
D
T
T
K
Q
I
I
K
A
L
S
G
N
K
V
T
V
F
G
L
T
Y
K
G
D
V
D
D
I
R
E
S
P
A
F
D
I
Y
E
L
L
N
Q
E
P
D
-
I
E
V
C
A
Y
D
P
H
V
E
L
D
F
V
E
H
--------------------------------------
D
-------
M
S
H
A
V
------
K
D
A
S
L
V
L
I
L
--
S
D
H
S
E
F
K
N
L
S
D
S
H
F
D
----
K
---
M
K
H
K
V
I
F
D
T
K
N
V
V
---------------------
1
PsiBlast_PDB
75.51
34%
13
- C1 -
-
4R16
2
?
A:
[2-395]
------
R
I
A
V
L
G
L
G
Y
I
G
L
P
---
T
A
I
M
F
---
A
S
---
S
G-
Y
---
D
V
V
G
Y
D
I
R
S
----
E
----
V
I
K
K
I
N
S
G
V
----
A
H
I
--
I
E
--
P
--
E
I
D
R
R
-
L
----
K
E
--
V
---
L
---
S
L
GK
L
K
V
T
D
R
-
V
E
-
D
L
---
K
G
S
N
V
F
I
I
C
V
Q
T
P
L
S
G
--------
D
--
D
P
D
L
S
Y
L
E
R
A
I
R
T
V
A
E
V
M
D
---
R
G
A
L
V
I
I
E
S
T
I
P
P
G
T
T
E
K
-
M
A
-
R
L
L
E
N
L
T
G
L
R
E
G
V
D
F
Y
V
A
H
A
P
E
R
V
M
P
G
R
I
F
K
E
L
V
Y
N
S
R
I
I
-
G
G
-----
V
-
S
-
E
-----
K
----
A
A
N
L
A
---
E
K
L
Y
R
S
-
F
V
K
-
G
-
R
I
F
L
T
N
A
----
T
T
A
E
M
V
K
L
M
E
N
T
F
R
D
V
N
I
A
L
A
N
E
F
A
L
L
A
H
Q
Y
G
V
N
V
Y
E
A
------
I
E
L
A
N
--
T
----
H
--
P
----
R
V
K
I
--------
H
T
P
G
I
G
V
G
G
H
C
L
P
K
D
P
Y
L
L
L
S
N
A
K
E
----
D
F
G
L
-----------------
I
R
I
A
R
--
R
I
N
E
R
M
P
A
F
A
A
G
L
L
F
E
A
L
E
K
A
N
I
K
P
S
-
E
A
I
I
A
V
L
G
L
A
Y
K
G
G
T
D
D
T
R
N
S
P
A
L
K
F
V
E
I
I
-
R
N
S
V
-
K
E
V
R
T
Y
D
P
Y
V
R
G
T
---
H
---------------
D
-------------------
S
L
E
K
-------
V
V
E
G
A
-------
D
A
--
I
V
I
A
--
T
D
H
P
E
F
K
S
V
N
W
E
S
I
G
K
-
S
M
R
---
H
K
I
-
I
I
----------------------------
22
PsiBlast_CBE
74.33
32%
13
- C1 -
-
3OJL
1
?
B:
[13-410]
------
K
L
T
V
V
G
L
G
Y
I
G
L
P
---
T
S
I
M
F
---
A
K
---
H
G-
V
---
D
V
L
G
V
D
I
N
Q
----
Q
----
T
I
D
K
L
Q
N
G
Q
IS
I
E
E
P
G
--
L
Q
E
V
Y
--
E
---
E
-
V
----
L
S
--
S
---
G
---
K
L
---
K
V
S
T
-----
T
P
---
E
A
S
D
V
F
I
I
A
V
P
T
P
N
N
D
DQ
Y
-----
R
--
S
C
D
I
S
L
V
M
R
A
L
D
S
I
L
P
F
L
K
---
K
G
N
T
I
I
V
E
S
T
I
A
P
K
T
M
D
D
-
F
V
K
P
V
I
E
N
L
-
G
F
T
I
G
E
D
I
Y
L
V
H
C
P
E
R
V
L
P
G
K
I
L
E
E
L
V
H
N
N
R
I
I
-
G
G
-----
V
-
T
-
K
-----
A
----
C
I
E
A
G
---
K
R
V
Y
R
T
-
F
V
Q
-
G
-
E
M
I
E
T
D
A
----
R
T
A
E
M
S
K
L
M
E
N
T
Y
R
D
V
N
I
A
L
A
N
E
L
T
K
I
C
N
N
L
N
I
N
V
L
D
V
------
I
E
M
A
N
--
K
----
H
--
P
----
R
V
N
I
--------
H
Q
P
G
P
G
V
G
G
H
C
L
A
V
D
P
Y
F
-------------------
N
---
A
--
K
----
L
I
Q
T
G
R
--
E
I
N
N
S
M
P
A
Y
V
V
-----
D
T
T
K
Q
I
I
K
A
L
S
G
N
K
V
T
V
F
G
L
T
Y
K
G
D
V
D
D
I
R
E
S
P
A
F
D
I
Y
E
L
L
N
Q
E
P
D
-
I
E
V
C
A
Y
D
P
H
V
E
L
D
F
V
E
H
--------------------------------------
D
-------
M
S
H
A
V
------
K
D
A
S
L
V
L
I
L
--
S
D
H
S
E
F
K
N
L
S
D
S
H
F
D
----
K
---
M
K
H
K
V
I
F
D
T
K
N
V
V
---------------------
3
PsiBlast_PDB
74.21
32%
10
- C1 -
-
3OJO
7
?
A:
[13-410]
------
K
L
T
V
V
G
L
G
Y
I
G
L
P
---
T
S
I
M
F
---
A
K
---
H
G-
V
---
D
V
L
G
V
D
I
N
Q
----
Q
----
T
I
D
K
L
Q
N
G
Q
IS
I
E
E
P
G
--
L
Q
E
V
Y
--
E
---
E
-
V
----
L
S
--
S
---
G
---
K
L
---
K
V
S
T
-----
T
P
---
E
A
S
D
V
F
I
I
A
V
P
T
P
N
N
D
DQ
Y
-----
R
--
S
C
D
I
S
L
V
M
R
A
L
D
S
I
L
P
F
L
K
---
K
G
N
T
I
I
V
E
S
T
I
A
P
K
T
M
D
D
-
F
V
K
P
V
I
E
N
L
-
G
F
T
I
G
E
D
I
Y
L
V
H
C
P
E
R
V
L
P
G
K
I
L
E
E
L
V
H
N
N
R
I
I
-
G
G
-----
V
-
T
-
K
-----
A
----
C
I
E
A
G
---
K
R
V
Y
R
T
-
F
V
Q
-
G
-
E
M
I
E
T
D
A
----
R
T
A
E
M
S
K
L
M
E
N
T
Y
R
D
V
N
I
A
L
A
N
E
L
T
K
I
C
N
N
L
N
I
N
V
L
D
V
------
I
E
M
A
N
--
K
----
H
--
P
----
R
V
N
I
--------
H
Q
P
G
P
G
V
G
G
H
C
L
A
V
D
P
---------------------
N
---
A
--
K
----
L
I
Q
T
G
R
--
E
I
N
N
S
M
P
A
Y
V
V
-----
D
T
T
K
Q
I
I
K
A
L
S
G
N
K
V
T
V
F
G
L
T
Y
K
G
D
V
D
D
I
R
E
S
P
A
F
D
I
Y
E
L
L
N
Q
E
P
D
-
I
E
V
C
A
Y
D
P
H
V
E
L
D
F
V
E
H
--------------------------------------
D
-------
M
S
H
A
V
------
K
D
A
S
L
V
L
I
L
--
S
D
H
S
E
F
K
N
L
S
D
S
H
F
D
----
K
---
M
K
H
K
V
I
F
D
T
K
N
V
V
---------------------
39
HHSearch
74.20
27%
6
- C1 -
-
3G79
-
?
B:
[15-459]
-
R
G
P
I
K
K
I
G
V
L
G
M
G
Y
V
G
I
P
---
A
A
V
L
F
---
A
D
A--
P
CF
E
---
K
V
L
G
F
Q
R
N
S
KSSG
Y
----
K
I
E
M
L
N
R
G
E
----
S
P
L
KG
E
E
P
G
L
--
E
---
E
L
I
----
G
K
--
V
VKA
G
---
K
F
---
E
C
T
P
D
-
F
S
-
R
I
---
S
E
L
D
A
V
T
L
A
I
Q
T
P
F
A
N
PK
D
-----
L
--
E
P
D
F
S
A
L
I
D
G
I
R
N
V
G
K
Y
L
K
---
P
G
M
L
V
V
L
E
S
T
I
T
P
G
T
T
E
G
-
M
A
K
Q
I
L
E
E
E
S
G
L
K
A
G
E
D
F
A
L
A
H
A
P
E
R
V
M
V
G
R
L
L
K
N
I
R
E
H
D
R
I
V
-
G
G
-----
I
-
D
-
E
-----
A
----
S
T
K
R
A
---
V
E
L
Y
S
P
-
V
L
T
V
G
-
Q
V
I
P
M
S
A
----
T
A
A
E
V
T
K
T
A
E
N
T
F
R
D
L
Q
I
A
A
I
N
Q
L
A
L
Y
C
E
A
M
G
I
N
V
Y
D
V
------
R
T
G
V
D
--
S
----
L
--
K
GEGI
T
R
A
V
--------
L
W
P
G
A
G
V
G
G
H
C
L
T
K
D
T
Y
H
L
E
R
G
V
-
K
IGRG
E
L
D
Y
----
P
EGA
D
--
S
----
I
Y
V
L
A
R
--
K
V
N
D
F
M
P
A
H
M
Y
N
L
T
V
A
A
L
E
R
L
G
K
K
M
D
-
G
S
K
V
A
M
L
G
W
A
F
I
K
D
S
D
D
A
R
N
T
P
S
E
P
Y
R
D
L
C
-
L
K
A
G
-
A
S
V
M
V
H
D
P
Y
V
V
N
Y
P
G
V
E
-----------------------------
I
---
S
D
N
-
L
E
-------
E
V
V
R
N
------
A
D
A
--
I
V
V
L
--
A
G
H
S
A
Y
S
S
L
K
A
D
W
A
K
K
V
S
A
K
---
A
N
P
-
V
I
I
D
G
R
N
V
I
E
P
D
E
F
I
---------------
37
HHSearch
73.39
27%
18
- C1 -
-
4XR9
2
?
B:
[12-441]
-
E
P
S
P
L
K
V
V
I
A
G
A
G
Y
V
G
T
C
---
L
A
V
T
L
---
A
G
---
R
G
-
A
---
E
V
V
A
V
D
S
D
P
----
G
----
T
V
A
D
L
R
A
G
R
----
C
R
L
--
P
E
P
G
L
--
A
---
G
-
A
V
---
R
D
--
L
A
A
T
G
---
R
L
---
T
A
S
T
S
-
Y
D
-
P
V
---
G
A
A
D
V
V
I
V
T
V
G
T
P
T
D
A
--
G
-----
H
--
E
M
V
T
D
Q
L
V
A
A
C
E
Q
I
A
P
R
L
R
---
A
G
Q
L
V
I
L
K
S
T
V
S
P
G
T
T
R
T
-
L
V
A
P
L
L
E
S
-
G
G
L
V
H
E
R
D
F
G
L
A
F
C
P
E
R
L
A
E
G
V
A
L
A
Q
V
R
T
L
P
V
V
V
-
G
G
-----
C
-
G
-
P
-----
R
----
S
A
A
A
A
---
E
R
F
W
R
S
A
L
G
V
D
--
V
R
Q
V
P
S
A
----
E
S
A
E
V
V
K
L
A
T
N
W
W
I
D
A
N
V
A
I
A
N
E
L
A
R
Y
C
A
V
L
G
V
D
V
L
D
V
------
I
G
A
A
N
--
T
----
L
--
P
KGSS
M
V
N
L
--------
L
L
P
G
V
G
V
G
--
C
L
T
K
D
P
W
M
A
W
R
D
G
-
R
----
D
R
G
V
----
S
---
L
--
R
----
T
V
E
T
A
R
--
A
V
N
D
D
M
P
R
H
T
A
A
V
I
A
D
E
L
V
K
L
G
R
D
R
N
-
D
T
T
I
A
V
L
G
A
A
F
K
N
D
T
G
D
V
R
N
T
P
V
R
G
V
V
A
A
L
-
R
D
S
G
-
F
R
V
R
I
F
D
P
L
A
D
P
A
E
I
V
A
---------------
R
-------------
F
GT
A
P
A
A
S
L
D
-------
E
A
V
S
G
------
A
G
C
--
L
A
F
L
--
A
G
H
R
Q
F
H
E
L
D
F
G
A
L
A
E
-
R
V
D
---
E
P
C
-
L
V
F
D
G
R
M
H
L
P
P
A
R
I
----------------
38
HHSearch
73.30
27%
14
- C1 -
-
4XR9
2
?
A:
[12-441]
-
E
P
S
P
L
K
V
V
I
A
G
A
G
Y
V
G
T
C
---
L
A
V
T
L
---
A
G
---
R
G
-
A
---
E
V
V
A
V
D
S
D
P
----
G
----
T
V
A
D
L
R
A
G
R
----
C
R
L
--
P
E
P
G
L
--
A
---
G
-
A
V
---
R
D
--
L
A
A
T
G
---
R
L
---
T
A
S
T
S
-
Y
D
-
P
V
---
G
A
A
D
V
V
I
V
T
V
G
T
P
T
D
A
--
G
-----
H
--
E
M
V
T
D
Q
L
V
A
A
C
E
Q
I
A
P
R
L
R
---
A
G
Q
L
V
I
L
K
S
T
V
S
P
G
T
T
R
T
-
L
V
A
P
L
L
E
S
-
G
G
L
V
H
E
R
D
F
G
L
A
F
C
P
E
R
L
A
E
G
V
A
L
A
Q
V
R
T
L
P
V
V
V
-
G
G
-----
C
-
G
-
P
-----
R
----
S
A
A
A
A
---
E
R
F
W
R
S
A
L
G
V
D
--
V
R
Q
V
P
S
A
----
E
S
A
E
V
V
K
L
A
T
N
W
W
I
D
A
N
V
A
I
A
N
E
L
A
R
Y
C
A
V
L
G
V
D
V
L
D
V
------
I
G
A
A
N
--
T
----
L
--
P
KGSS
M
V
N
L
--------
L
L
P
G
V
G
V
G
G
S
C
L
T
K
D
P
W
M
A
W
R
D
G
-
R
----
D
R
G
V
----
S
---
L
--
R
----
T
V
E
T
A
R
--
A
V
N
D
D
M
P
R
H
T
A
A
V
I
A
D
E
L
V
K
L
G
R
D
R
N
-
D
T
T
I
A
V
L
G
A
A
F
K
N
D
T
G
D
V
R
N
T
P
V
R
G
V
V
A
A
L
-
R
D
S
G
-
F
R
V
R
I
F
D
P
L
A
D
P
A
E
I
V
A
---------------
R
-------------
F
GT
A
P
A
A
S
L
D
-------
E
A
V
S
G
------
A
G
C
--
L
A
F
L
--
A
G
H
R
Q
F
H
E
L
D
F
G
A
L
A
E
-
R
V
D
---
E
P
C
-
L
V
F
D
G
R
M
H
L
P
P
A
R
I
----------------
6
PsiBlast_PDB
70.57
28%
19
- C1 -
-
3G79
-
?
A:
[20-433]
------
K
I
G
V
L
G
M
G
Y
V
G
I
P
---
A
A
V
L
F
---
A
D
---
A
--
P
CFE
K
V
L
G
F
Q
R
N
S
----
K
SS
G
Y
K
I
E
M
L
N
R
G
E
----
S
P
L
--
K
G
E
E
P
G
L
E
---
E
-
L
I
G
K
V
V
K
--
A
---
G
---
K
F
---
E
C
T
P
D
-
F
S
-
R
I
---
S
E
L
D
A
V
T
L
A
I
Q
T
P
F
A
N
--
P
-----
K
DL
E
P
D
F
S
A
L
I
D
G
I
R
N
V
G
K
Y
L
K
---
P
G
M
L
V
V
L
E
S
T
I
T
P
G
T
T
E
G
-
M
A
K
Q
I
L
E
E
E
S
G
L
K
A
G
E
D
F
A
L
A
H
A
P
E
R
V
M
V
G
R
L
L
K
N
I
R
E
H
D
R
I
V
-
G
G
-----
I
-
D
-
E
-----
A
----
S
T
K
R
A
---
V
E
L
Y
S
P
-
V
L
T
V
G
-
Q
V
I
P
M
S
A
----
T
A
A
E
V
T
K
T
A
E
N
T
F
R
D
L
Q
I
A
A
I
N
Q
L
A
L
Y
C
E
A
M
G
I
N
V
Y
D
V
R
T
G
V
D
S
L
K
G
E
G
--
I
----
T
--
R
----
A
V
L
----------
W
P
G
A
G
V
G
G
H
C
L
T
K
D
T
Y
H
L
-
E
R
G
-
V
----
K
I
G
R
G
E
L
D
Y
---
P
--
E
GADS
I
Y
V
L
A
R
--
K
V
N
D
F
M
P
A
H
M
Y
N
L
T
V
A
A
L
E
R
L
G
K
K
M
D
-
G
S
K
V
A
M
L
G
W
A
F
I
K
D
S
D
D
A
R
N
T
P
S
E
P
Y
R
D
L
C
-
L
K
A
G
-
A
S
V
M
V
H
D
P
Y
V
V
N
Y
---------------------------------------
P
G
V
E
-------
I
S
D
N
L
E
E
V
V
RN
A
D
A
--
I
V
V
L
--
A
G
H
S
A
Y
S
S
L
K
A
D
---------------------------------------------
41
HHSearch
68.41
25%
6
- C1 -
-
3VTF
2
?
A:
[17-436]
R
G
S
H
M
A
S
L
S
V
L
G
L
G
Y
V
G
V
V
---
H
A
V
G
F
---
A
L
---
L
G
-
H
---
R
V
V
G
Y
D
V
N
P
----
S
----
I
V
E
R
L
R
A
G
R
----
P
H
I
--
Y
E
P
G
L
--
E
---
E
A
L
----
G
R
--
A
---
L
S
S
G
R
L
---
S
F
A
E
S
A
E
E
-
A
V
---
A
A
T
D
A
T
F
I
A
V
G
T
P
P
A
P
--
D
-----
G
--
S
A
D
L
R
Y
V
E
A
A
A
R
A
V
G
R
G
I
R
A
K
G
R
W
H
L
V
V
V
K
S
T
V
P
P
G
T
T
E
G
-
L
V
A
R
A
V
A
E
--
E
A
G
-
G
V
K
F
S
V
A
S
N
P
E
F
L
R
E
G
S
A
L
E
D
F
F
K
P
D
R
I
V
-
I
G
-----
A
G
D
-
E
-----
R
----
A
A
S
F
L
---
L
D
V
Y
K
A
-
V
D
A
P
--
K
L
V
M
-
K
P
----
R
E
A
E
L
V
K
Y
A
S
N
V
F
L
A
L
K
I
S
F
A
N
E
V
G
L
L
A
K
R
L
G
V
D
T
Y
R
V
------
F
E
A
V
G
--
L
----
D
KR
I
----
G
R
H
Y
--------
F
G
A
G
L
G
F
G
G
S
C
F
P
K
D
T
L
A
F
I
R
F
G
-
E
----
S
L
G
L
----
E
---
M
--
A
----
I
S
K
A
V
L
--
R
V
N
E
Y
M
P
R
Y
A
V
Q
L
L
E
E
R
L
G
----
G
L
R
-
G
R
H
V
G
V
L
G
L
A
F
K
P
N
T
D
D
V
R
E
S
R
G
V
E
V
A
R
L
L
-
L
E
R
G
-
A
R
V
Y
V
H
D
P
M
A
M
E
K
A
R
A
V
LGD------------
S
-------------
V
--
T
Y
V
E
D
P
Q
-------
A
L
L
D
Q
------
V
E
G
--
V
I
I
A
--
T
A
W
P
Q
Y
E
G
L
D
--
Y
----------
R
G
K
-
V
V
V
D
G
R
Y
V
K
K
A
R
E
A
K
---------------
52
Fugue
67.71
21%
-3
- C1 -
-
2Q3E
2
UGDH_HUMAN
A:
[2-467]
-
M
F
E
I
K
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
---
C
P
---
E
--
I
---
R
V
T
V
V
D
V
N
E
----
S
----
R
I
N
A
W
N
S
P
T
----
L
P
I
--
Y
E
P
G
L
--
K
---
E
-
V
----
V
E
--
S
---
C
RGK
N
L
---
F
F
S
T
N
-
I
D
D
A
I
---
K
E
A
D
L
V
F
I
S
V
N
T
P
T
K
T
--
Y
GMGKG
R
--
A
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
N
---
G
Y
K
I
V
T
E
K
S
T
V
P
V
R
A
A
E
S
-
I
R
R
I
F
D
A
N
---
T
K
P
N
L
N
L
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
-
I
G
G
D
ET
P
E
-
G
-
Q
-----
R
----
A
V
Q
A
L
---
C
A
V
Y
E
H
-
W
V
P
R
E
-
K
I
L
T
T
N
T
----
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
------
A
T
A
I
G
--
M
DQRI
G
--
N
----
K
F
L
K
--------
A
S
V
G
F
--
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
-
E
----
A
L
N
L
----
P
---
E
--
V
----
A
R
Y
W
Q
Q
V
I
D
M
N
D
Y
Q
R
R
R
F
A
S
R
I
I
D
S
L
---
F
N
T
V
T
-
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
-
M
D
E
G
-
A
H
L
H
I
Y
D
P
K
V
P
R
E
Q
I
V
V
---------------
D
-------------
L
--
S
H
D
Q
V
S
R
L
V
T
I
S
KD
P
Y
E
A
C
DG----
A
H
A
--
V
V
I
C
--
T
E
W
D
M
F
K
E
L
D
Y
E
R
I
H
K
-
K
M
L
---
K
P
A
-
F
I
F
D
G
R
R
V
L
D
G
L
H
N
E
L
Q
T
I
GFQ
I
E
T
I
GKKV
32
HHSearch
67.51
20%
3
- C1 -
-
3KHU
8
UGDH_HUMAN
B:
[1-450]
S
M
F
E
I
K
K
I
C
C
I
G
A
G
Y
V
G
G
P
---
T
C
S
V
I
---
A
H
MCP
E
--
I
---
R
V
T
V
V
D
V
N
E
----
S
----
R
I
N
A
W
N
S
P
T
----
L
P
I
--
Y
E
P
G
L
--
K
---
E
-
V
V---
E
S
CR
G
---
K
---
N
L
---
F
F
S
T
N
I
D
D
-
A
I
---
K
E
A
D
L
V
F
I
S
V
N
T
P
T
K
T
--
Y
GMGKG
R
--
A
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
N
---
G
Y
K
I
V
T
E
K
S
T
V
P
V
R
A
A
E
S
-
I
R
R
-
I
F
D
A
-
N
T
K
P
N
-
L
N
L
Q
V
L
S
N
P
Q
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
-
I
G
-----
G
-
D
-
E
T----
P
EGQR
A
V
Q
A
L
---
C
A
V
Y
E
H
-
W
V
P
R
E
-
K
I
L
T
T
N
T
----
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
------
A
T
A
I
G
--
M
----
D
QR
I
----
G
N
K
F
--------
L
K
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
-
E
----
A
L
N
L
----
P
EV-
A
--
R
----
Y
W
Q
Q
V
I
--
D
M
N
D
Y
Q
R
R
R
F
A
S
R
I
I
D
S
L
F
N
---
T
V
T
-
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
-
M
D
E
G
-
A
H
L
H
I
Y
D
P
K
V
P
R
E
Q
I
V
V
DLSHPGVSEDDQVSR
L
-------------
V
--
T
I
S
K
D
P
Y
-------
E
A
C
D
G
------
A
H
A
--
V
V
I
C
--
T
E
W
D
M
F
K
E
L
D
Y
E
R
I
H
K
-
K
M
L
---
K
P
A
-
F
I
F
D
G
R
R
V
L
D
G
L
H
-----------------
7
PsiBlast_PDB
67.51
28%
-8
- C1 -
-
3VTF
1
?
A:
[23-374]
------
S
L
S
V
L
G
L
G
Y
V
G
V
V
---
H
A
V
G
F
A
L
L
G
H
---
R
--
V
-----
V
G
Y
D
V
N
P
----
S
----
I
V
E
R
L
R
A
G
R
----
P
H
I
--
Y
E
P
G
L
--
E
---
E
A
L
----
G
R
--
A
---
L
S
S
G
R
L
---
S
F
A
E
S
-
A
E
-
E
A
V
A
A
T
D
A
T
F
I
A
V
G
T
P
P
A
P
D
G
-----------
S
A
D
L
R
Y
V
E
A
A
A
R
A
V
G
R
G
I
R
A
K
G
R
W
H
L
V
V
V
K
S
T
V
P
P
G
T
T
E
G
L
V
A
R
A
V
A
E
E
A
G
G
V
K
F
S
----
V
A
S
N
P
E
F
L
R
E
G
S
A
L
E
D
F
F
K
P
D
R
I
V
-
I
G
-----
A
-
G
-
D
-----
E
R
---
A
A
S
F
L
---
L
D
V
Y
K
A
-
V
-------
D
A
P
K
L
V
M
K
P
R
E
A
E
L
V
K
Y
A
S
N
V
F
L
A
L
K
I
S
F
A
N
E
V
G
L
L
A
K
R
L
G
V
D
T
Y
R
V
------
F
E
A
V
G
L
D
K
----
R
--
I
----
G
R
H
Y
--------
F
G
A
G
L
G
F
G
G
S
C
F
P
K
D
T
L
A
F
I
R
F
G
-
E
----
S
L
G
L
----
E
---
M
--
A
----
I
S
K
A
V
L
--
R
V
N
E
Y
M
P
R
Y
-
A
V
Q
L
L
E
E
R
L
G
G
---
L
R
-
G
R
H
V
G
V
L
G
L
A
F
K
P
N
T
D
D
V
R
E
S
R
G
V
E
V
A
R
L
L
-
L
E
R
G
-
A
R
V
Y
V
H
D
P
--------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
66.62
21%
3
- C1 -
-
2O3J
4
UGDH_CAEEL
A:
[5-455]
V
F
G
K
V
S
K
V
V
C
V
G
A
G
Y
V
G
G
P
---
T
C
A
M
I
---
A
H
K
C
P
H
--
I
---
T
V
T
V
V
D
M
N
T
----
A
----
K
I
A
E
W
N
S
D
K
----
L
P
I
--
Y
E
P
G
L
--
D
---
E
-
I
----
V
F
A
-
A
RG-
R
---
N
L
---
F
F
S
S
D
I
P
K
-
A
I
---
A
E
A
D
L
I
F
I
S
V
N
T
P
T
K
M
--
Y
GRGKG
M
--
A
P
D
L
K
Y
V
E
S
V
S
R
T
I
A
Q
Y
A
G
---
G
P
K
I
V
V
E
K
S
T
V
P
V
K
A
A
E
S
-
I
G
C
-
I
L
R
E
A
Q
K
----
L
K
F
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
M
K
D
L
A
N
P
D
R
V
L
I
G
G
-----
E
-
S
S
P
-----
E
----
G
L
Q
A
V
A
E
L
V
R
I
Y
E
N
-
W
V
P
R
N
-
R
I
I
T
T
N
T
----
W
S
S
E
L
S
K
L
V
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
V
C
E
A
T
G
A
E
I
S
E
V
------
A
H
A
V
G
--
Y
----
D
TR
I
----
G
S
K
F
--------
L
Q
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
S
L
V
Y
L
C
-
E
----
S
L
N
L
----
P
---
Q
V
A
D
----
Y
W
Q
G
V
I
--
N
I
N
N
W
Q
R
R
R
F
A
D
K
I
I
A
E
L
F
N
---
T
V
T
-
D
K
K
I
A
I
F
G
F
A
F
K
K
N
T
G
D
T
R
E
S
S
A
I
H
V
I
K
H
L
-
M
E
E
H
-
A
K
L
S
V
Y
D
P
K
V
Q
K
S
Q
M
L
N
---------------
D
L
A
S
V
TS
A
Q
D
V
E
R
L
I
--
T
V
E
S
D
P
Y
-------
A
A
A
R
G
------
A
H
A
--
I
V
V
L
--
T
E
W
D
E
F
V
E
L
N
Y
S
Q
I
H
N
-
D
M
Q
---
H
P
A
-
A
I
F
D
G
R
L
I
L
D
Q
K
A
L
----------------
33
HHSearch
66.50
21%
8
- C1 -
-
2O3J
3
UGDH_CAEEL
C:
[6-455]
-
F
G
K
V
S
K
V
V
C
V
G
A
G
Y
V
G
G
P
---
T
C
A
M
I
---
A
H
KCP
H
--
I
---
T
V
T
V
V
D
M
N
T
----
A
----
K
I
A
E
W
N
S
D
K
----
L
P
I
--
Y
E
P
G
L
--
D
---
E
-
I
----
V
F
A-
A
RG-
R
---
N
L
---
F
F
S
S
D
I
P
K
-
A
I
---
A
E
A
D
L
I
F
I
S
V
N
T
P
T
K
M
--
Y
GRGKG
M
--
A
P
D
L
K
Y
V
E
S
V
S
R
T
I
A
Q
Y
A
G
---
G
P
K
I
V
V
E
K
S
T
V
P
V
-
A
A
E
S
-
I
G
C
-
I
L
R
E
A
Q
K
----
L
K
F
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
M
K
D
L
A
N
P
D
R
V
L
I
G
G
-----
E
-
S
S
P
-----
E
----
G
L
Q
A
V
AEL
V
R
I
Y
E
N
-
W
V
P
R
N
-
R
I
I
T
T
N
T
----
W
S
S
E
L
S
K
L
V
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
V
C
E
A
T
G
A
E
I
S
E
V
------
A
H
A
V
G
--
Y
----
D
TR
I
----
G
S
K
F
--------
L
Q
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
S
L
V
Y
L
C
-
E
----
S
L
N
L
----
P
---
Q
VA
D
----
Y
W
Q
G
V
I
--
N
I
N
N
W
Q
R
R
R
F
A
D
K
I
I
A
E
L
F
N
---
T
V
T
-
D
K
K
I
A
I
F
G
F
A
F
K
K
N
T
G
D
T
R
E
S
S
A
I
H
V
I
K
H
L
-
M
E
E
H
-
A
K
L
S
V
Y
D
P
K
V
Q
K
S
Q
M
L
N
---------------
D
LASVTSAQDVERL
I
--
T
V
E
S
D
P
Y
-------
A
A
A
R
G
------
A
H
A
--
I
V
V
L
--
T
E
W
D
E
F
V
E
L
N
Y
S
Q
I
H
N
-
D
M
Q
---
H
P
A
-
A
I
F
D
G
R
L
I
L
D
Q
K
A
L
----------------
28
HHSearch
66.46
23%
25
- C1 -
-
2Y0C
5
?
A:
[7-448]
---
G
S
M
N
L
T
I
I
G
S
G
S
V
G
L
V
---
T
G
A
C
L
---
A
D
---
I
G-
H
---
D
V
F
C
L
D
V
D
Q
----
A
----
K
I
D
I
L
N
N
G
G
----
V
P
I
--
H
E
P
G
L
--
K
---
E
V
I
----
A
R
--
N
R
S
A
G
---
R
L
---
R
F
S
T
D
I
E
A
-
A
V
---
A
H
G
D
V
Q
F
I
A
V
G
T
P
P
D
E
--
D
-----
G
--
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
-
V
R
A
A
V
A
E
E
L
A
K
R
G
G
D
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
-
I
G
-----
C
-
D
-
D
D
V
P
G
E
R
----
A
R
E
L
M
---
K
K
L
Y
A
P
-
F
N
R
N
H
E
R
T
L
Y
M
D
V
----
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
------
R
R
G
I
G
--
S
----
D
--
P
RI--
G
Y
H
F
--------
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
-
D
----
E
H
G
Q
----
S
---
L
--
Q
----
I
L
K
A
V
S
--
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
A
R
F
G
E
---
D
L
T
-
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
-
L
S
R
G
-
A
R
I
A
A
Y
D
P
V
A
Q
E
E
A
R
R
V
I
A
L
D
L
A
DH
P
S
W
L
E
--
R
-------------
L
--
S
F
V
D
D
E
A
-------
Q
A
A
R
D
------
A
D
A
--
L
V
I
V
--
T
E
W
K
I
F
K
S
P
D
F
V
A
L
G
R
-
L
W
K
---
T
-
P
-
V
I
F
D
G
R
N
L
Y
E
P
E
T
M
S
---------------