@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMZ8: (2017-11-11 )
MMNSPNVNSYHPDLVVEEAKNGWRIVRLNRPKSLHALDESIVTALLRVFEDFRDDEQVKAIWLDSTTPKAFCAGGDVRKLRQLVINQEVETANKFFQQEYALDLLLHNYAKPVVVWGEGYVMGGGLGLFMAAPFRLVTPYSRLAMPEINIGLYPDVGASRFLADRGQIGLFTGLTGSIMTAAGAYSIGWATHICEAQRDNVLQKVLNINWAHYPAGDFRAIDDTLNSLHRPVAAGPLQNSLDVIHSVCRGSSFEQDYQAIVSLRDASSDWLRQASENLQKGSPSTAAITWLLWQWGKQVHSWDEVFDLEAQISEWKIRHPDFVEGVRARLVDKDLSPEWKACEDLTLRGILADDPPITTIDSWNALLRQYGIVS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80....---...---.-------90........100.......110.......120.......130......-.140.......150.---......----160.---.-.-.--...170.....--..180.......190-..-.-.-...200.......210--.........220.......230--..-----.----.--.....240.......250.......260.......270........280.......290.....-..300..-.....310.......320.......330.......340.--...---...350.......360.......370..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MMNSPNVNSYHPD
L
V
V
E
EAKNG
W
R
I
V
R
LNRPK
S
L
H
A
L
D
E
S
I
V
T
A
L
L
R
V
F
E
D
FRDDE
Q
V
K
A
I
W
LDSTTPK
A
F
CAGG
D
V
R
K
L
R
Q
L
V
I---NQ
E
---
V
-------
E
T
A
N
K
F
F
Q
Q
E
Y
A
L
D
L
L
L
H
NYAK
P
V
V
V
WGE
G
Y
V
MGGG
L
G
L
F
MAA
P
F
R
LVT-
P
Y
S
RLAMPEINIGLY---PDV
G
A
S
----
R
F
LA---D-R-G--Q
I
G
L
FTGLT
G
S
--
I
M
TAAGAYSIG
W
A
T
H
-
I
C
-
E
-
A
-
Q
R
D
N
V
L
Q
K
V
LNINW----AHYPAGD
F
R
A
I
D
D
T
L
N
S
LHR----PV-----A----A--GP
L
Q
N
S
L
D
V
I
H
S
V
CRGS
S
F
E
Q
D
Y
Q
A
I
V
S
LRDA
S
S
D
W
L
-
R
Q
A
S
E
N
LQKGSP
S
T
A
A
I
T
W
L
L
W
Q
W
G
K
-QVH
S
W
D
E
-
V
F
D
L
E
A
Q
I
S
EWKIRH
P
D
F
V
E
G
V
R
A
R
L
VDKDLSPE
W
K
A
C
E
--D
L
T
---
L
R
G
ILADDPPIT
T
I
D
S
W
N
A
L
L
R
QYGIVS
34
HHSearch
86.49
37%
-47
- C2 -
-
3JU1
4
?
A:
[47-395]
-----------------
A
S
G
K
L
V
G
V
V
T
L
N
V
E
K
A
L
N
A
L
D
L
D
M
V
R
A
M
T
V
Q
L
N
L
W
K
K
D
P
L
I
A
C
V
V
L
D
G
S
G
E
K
A
F
C
A
G
G
D
V
R
A
L
Y
H
A
S
V
---
A
A
K
GQV
T
-------
E
V
A
K
V
F
F
E
E
E
Y
R
L
D
Y
L
L
H
T
Y
G
K
P
V
L
V
W
G
D
G
I
V
M
G
G
G
L
G
L
M
A
G
A
S
H
K
V
V
T
-
E
T
S
R
I
A
M
P
E
V
T
I
G
L
Y
---
P
D
V
G
G
S
----
Y
F
L
N
---
R
M
P
-
G
--
K
M
G
L
F
L
G
L
T
A
Y
--
H
M
N
A
A
D
A
C
Y
V
G
L
A
D
H
-
Y
L
-
N
R
D
-
D
K
E
L
M
F
D
A
M
A
T
L
D
W
----
S
D
S
P
A
L
N
H
Q
R
L
D
T
M
I
N
E
L
S
N
----
Q
V
-----
D
IPKG
D
--
S
V
L
A
E
S
Q
E
M
I
D
R
L
M
-
A
G
S
L
T
D
I
V
T
R
M
S
T
L
-
S
T
D
E
A
W
L
-
S
K
A
C
A
T
M
L
A
G
S
P
I
S
W
H
L
A
Y
I
Q
T
Q
L
G
T
-
K
L
-
S
L
A
Q
-
C
F
K
W
E
L
T
V
S
V
N
V
C
A
K
G
D
F
C
E
G
V
R
A
L
L
I
D
K
D
K
Q
P
K
W
Q
F
A
D
VQ
S
V
P
N
S
V
I
E
D
I
L
T
S
P
W
-------------------
35
HHSearch
86.29
37%
-45
- C2 -
-
3JU1
4
?
B:
[47-396]
-----------------
A
S
G
K
L
V
G
V
V
T
L
N
V
E
K
A
L
N
A
L
D
L
D
M
V
R
A
M
T
V
Q
L
N
L
W
K
K
D
P
L
I
A
C
V
V
L
D
G
S
G
E
K
A
F
C
A
G
G
D
V
R
A
L
Y
H
A
S
V
---
A
A
K
GQV
T
-------
E
V
A
K
V
F
F
E
E
E
Y
R
L
D
Y
L
L
H
T
Y
G
K
P
V
L
V
W
G
D
G
I
V
M
G
G
G
L
G
L
M
A
G
A
S
H
K
V
V
T
-
E
T
S
R
I
A
M
P
E
V
T
I
G
L
Y
---
P
D
V
G
G
S
----
Y
F
L
N
---
R
M
P
-
G
--
K
M
G
L
F
L
G
L
T
A
Y
--
H
M
N
A
A
D
A
C
Y
V
G
L
A
D
H
-
Y
L
-
N
R
D
-
D
K
E
L
M
F
D
A
M
A
T
L
D
W
----
S
D
S
P
A
L
N
H
Q
R
L
D
T
M
I
N
E
L
S
N
----
Q
V
-----
D
IPKG
D
--
S
V
L
A
E
S
Q
E
M
I
D
R
L
M
-
A
G
S
L
T
D
I
V
T
R
M
S
T
L
-
S
T
D
E
A
W
L
-
S
K
A
C
A
T
M
L
A
G
S
P
I
S
W
H
L
A
Y
I
Q
T
Q
L
G
T
-
K
L
-
S
L
A
Q
-
C
F
K
W
E
L
T
V
S
V
N
V
C
A
K
G
D
F
C
E
G
V
R
A
L
L
I
D
K
D
K
Q
P
K
W
Q
F
A
D
VQ
S
V
P
N
S
V
I
E
D
I
L
T
S
P
W
G
------------------
1
PsiBlast_PDB
84.92
37%
-56
- C2 -
-
3JU1
4
?
A:
[54-375]
------------------------
V
V
T
L
N
V
E
K
A
L
N
A
L
D
L
D
M
V
R
A
M
T
V
Q
L
N
L
W
K
K
D
P
L
I
A
C
V
V
L
D
G
S
G
E
K
A
F
C
A
G
G
D
V
R
A
L
Y
H
A
S
V
A
A
K
G
Q
V
---
T
-------
E
V
A
K
V
F
F
E
E
E
Y
R
L
D
Y
L
L
H
T
Y
G
K
P
V
L
V
W
G
D
G
I
V
M
G
G
G
L
G
L
M
A
G
A
S
H
K
V
V
T
-
E
T
S
R
I
A
M
P
E
V
T
I
G
L
Y
---
P
D
V
G
G
S
----
Y
F
L
N
---
R
-
M
P
G
--
K
M
G
L
F
L
G
L
T
A
Y
--
H
M
N
A
A
D
A
C
Y
V
G
L
A
D
H
Y
L
N
-
R
-
D
-
D
K
E
L
M
F
D
A
M
A
T
L
D
W
----
S
D
S
P
A
L
N
H
Q
R
L
D
T
M
I
N
E
L
S
N
Q
VDI
P
K
-----
G
----
D
--
S
V
L
A
E
S
Q
E
M
I
D
R
L
M
A
G
S
L
--
T
D
I
V
T
R
M
S
T
L
S
T
D
E
A
W
L
-
S
K
A
C
A
T
M
L
A
G
S
P
I
S
W
H
L
A
Y
I
Q
T
Q
L
G
T
-
K
L
-
S
L
A
Q
-
C
F
K
W
E
L
T
V
S
V
N
V
C
A
K
G
D
F
C
E
G
V
R
A
L
L
I
D
K
D
K
Q
P
K
W
Q
---------------------------------------
36
HHSearch
75.80
29%
-59
- C2 -
-
3BPT
2
HIBCH_HUMAN
A:
[12-353]
------------------
K
K
G
C
T
G
V
I
T
L
N
R
P
K
F
L
N
A
L
T
L
N
M
I
R
Q
I
Y
P
Q
L
K
K
W
E
Q
D
P
E
T
F
L
I
I
I
K
G
A
G
G
K
A
F
C
A
G
G
D
I
R
V
I
S
E
A
E
K
---
A
K
Q
-----------
K
I
A
P
V
F
F
R
E
E
Y
M
L
N
N
A
V
G
S
C
Q
K
P
Y
V
A
L
I
H
G
I
T
M
G
G
G
V
G
L
S
V
H
G
Q
F
R
V
A
T
-
E
K
C
L
F
A
M
P
E
T
A
I
G
L
F
---
P
D
V
G
G
G
----
Y
F
L
P
---
R
L
Q
-
G
--
K
L
G
Y
F
L
A
L
T
G
F
--
R
L
K
G
R
D
V
Y
R
A
G
I
A
T
H
-
F
V
-
D
S
E
-
K
L
A
M
L
E
E
D
L
L
A
--
L
----
K
S
P
S
K
E
N
I
A
S
V
L
E
N
Y
H
T
E
S
K
----
I
D
-----
R
----
D
KS
F
I
L
E
E
H
M
D
K
I
N
S
C
F
S
A
N
T
V
E
E
I
I
E
N
L
Q
Q
---
D
G
S
S
F
A
-
L
E
Q
L
K
V
I
N
K
M
S
P
T
S
L
K
I
T
L
R
Q
L
M
E
G
S
-
S
K
-
T
L
Q
E
-
V
L
T
M
E
Y
R
L
S
Q
A
C
M
R
G
H
D
F
H
E
G
V
R
A
V
L
I
D
K
D
Q
S
P
K
W
K
P
A
D
LK
E
V
T
E
E
D
L
N
N
H
F
K
S
L
G
S
S
D
----------------
2
PsiBlast_PDB
73.59
30%
-58
- C2 -
-
3BPT
2
HIBCH_HUMAN
A:
[18-330]
------------------------
V
I
T
L
N
R
P
K
F
L
N
A
L
T
L
N
M
I
R
Q
I
Y
P
Q
L
K
K
W
E
Q
D
P
E
T
F
L
I
I
I
K
G
A
G
G
K
A
F
C
A
G
G
D
I
R
V
I
S
E
A
E
K
---
A
K
Q
-----------
K
I
A
P
V
F
F
R
E
E
Y
M
L
N
N
A
V
G
S
C
Q
K
P
Y
V
A
L
I
H
G
I
T
M
G
G
G
V
G
L
S
V
H
G
Q
F
R
V
A
T
-
E
K
C
L
F
A
M
P
E
T
A
I
G
L
F
---
P
D
V
G
G
G
----
Y
F
L
P
---
R
L
Q
-
G
--
K
L
G
Y
F
L
A
L
T
G
F
--
R
L
K
G
R
D
V
Y
R
A
G
I
A
T
H
-
F
V
-
D
-
S
-
E
K
L
A
M
L
E
E
--
D
L
L
A
----
L
K
S
P
S
K
E
--
N
I
A
S
V
L
E
N
Y
H
T
----
E
S
KIDRD
K
----
S
--
F
I
L
E
E
H
M
D
K
I
N
S
C
F
S
A
N
T
V
E
---
E
I
I
E
N
L
Q
Q
D
G
S
S
F
A
-
L
E
Q
L
K
V
I
N
K
M
S
P
T
S
L
K
I
T
L
R
Q
L
M
E
G
S
-
S
-
K
T
L
Q
E
-
V
L
T
M
E
Y
R
L
S
Q
A
C
M
R
G
H
D
F
H
E
G
V
R
A
V
L
I
D
K
D
Q
S
P
K
W
K
---------------------------------------
38
HHSearch
73.02
28%
-52
- C2 -
-
4J2U
-
?
B:
[2-334]
---------
S
D
V
L
I
R
---
K
V
R
R
A
G
R
I
T
L
S
R
P
A
A
L
N
A
L
T
C
A
M
V
Q
E
I
D
A
A
L
R
G
W
I
G
D
P
E
V
E
L
V
V
I
D
A
E
G
P
R
A
F
C
A
G
G
D
I
A
E
L
H
G
R
G
V
---
A
G
D
---
H
-------
A
F
G
Q
D
F
W
R
V
E
Y
R
M
N
D
R
I
A
A
F
P
K
P
I
V
S
L
M
Q
G
F
T
M
G
G
G
V
G
L
G
C
H
A
R
H
R
I
V
G
-
E
T
S
Q
I
S
M
P
E
C
A
I
G
L
V
---
P
D
V
G
G
T
----
H
L
L
A
---
R
A
P
-
G
--
R
I
G
V
W
L
G
L
T
G
A
--
R
M
G
P
G
D
A
I
F
A
G
F
A
D
R
-
F
V
P
E
-
A
-
D
W
P
D
L
I
A
A
L
E
G
-
G
D
----
L
A
L
P
------------
D
H
A
A
----
P
-----------
E
--
G
R
L
P
V
L
Q
D
E
I
D
R
L
F
A
-
G
T
L
A
E
I
P
A
R
L
E
A
---
T
D
T
P
L
A
-
A
E
A
L
K
A
L
R
R
S
S
P
L
A
L
A
A
T
L
E
I
L
Q
R
L
G
P
S
A
-
G
I
R
E
-
A
L
D
L
E
Y
R
F
T
Y
R
A
Q
G
Q
A
D
F
L
E
G
I
R
A
A
I
I
D
K
D
R
S
P
R
W
R
H
G
D
PE
A
V
R
P
E
E
V
A
S
L
L
A
P
L
G
P
Q
-----------------
3
PsiBlast_PDB
72.35
29%
-71
- C2 -
-
4J2U
-
?
A:
[3-312]
------------
D
V
L
I
R
K
V
R
R
A
G
R
I
T
-
L
S
R
P
A
A
L
N
A
L
T
C
A
M
V
Q
E
I
D
A
A
L
R
G
W
I
G
D
P
E
V
E
L
V
V
I
D
A
E
G
P
R
A
F
C
A
G
G
D
I
A
E
L
H
G
R
G
V
---
A
G
D
---
H
-------
A
F
G
Q
D
F
W
R
V
E
Y
R
M
N
D
R
I
A
A
F
P
K
P
I
V
S
L
M
Q
G
F
T
M
G
G
G
V
G
L
G
C
H
A
R
H
R
I
V
G
-
E
T
S
Q
I
S
M
P
E
C
A
I
G
L
V
---
P
D
V
G
G
T
----
H
L
L
A
---
R
-
A
P
G
--
R
I
G
V
W
L
G
L
T
G
A
--
R
M
G
P
G
D
A
I
F
A
G
F
A
D
R
-
F
--------------
V
P
E
A
D
W
P
D
L
I
A
A
L
E
G
G
D
L
A
L
P
D
H
A
A
P
E
G
R
L
----
P
V
---------------
L
Q
D
E
I
D
R
L
--------
F
A
G
T
L
A
E
I
P
A
R
L
E
A
T
D
T
P
L
A
A
E
A
L
K
A
L
R
R
S
S
P
L
A
L
A
A
T
L
E
I
L
Q
R
L
G
-
P
S
A
G
I
R
E
-
A
L
D
L
E
Y
R
F
T
Y
R
A
Q
G
Q
A
D
F
L
E
G
I
R
A
A
I
I
D
K
D
R
S
P
R
W
R
---------------------------------------
10
PsiBlast_PDB
56.76
27%
-131
- C2 -
-
3MYB
1
?
A:
[24-203]
----------
E
P
L
L
L
Q
D
R
D
E
R
G
V
V
T
L
T
L
N
R
P
Q
A
F
N
A
L
S
E
A
M
L
A
A
L
G
E
A
F
G
T
L
A
E
D
E
S
V
R
A
V
V
L
-
A
A
S
G
K
A
F
C
A
G
H
D
L
K
E
M
R
A
------
E
P
S
---
R
-------
E
Y
Y
E
K
L
F
A
R
C
T
D
V
M
L
A
I
Q
R
L
P
A
P
V
I
A
R
V
H
G
I
A
T
A
A
G
C
Q
L
V
A
M
C
D
L
A
V
A
T
-
R
D
A
R
F
A
V
S
G
I
N
V
G
L
F
C
S
T
P
G
V
A
L
S
----
R
N
V
G
---
R
-
K
-
A
--
A
F
E
M
L
--
V
T
G
E
--
F
V
S
A
D
D
A
K
G
L
G
L
V
N
R
-
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
56.32
24%
-88
* C2 *
-
3H81
3
ECHA8_MYCTU
C:
[23-278]
----------
T
Y
E
T
I
L
V
E
R
D
Q
R
V
G
I
I
T
L
N
R
P
Q
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
K
-
A
F
A
A
G
A
D
I
K
E
M
A
D
L
T
F
-------------------
A
D
A
F
T
A
D
F
F
A
T
W
G
K
L
A
A
V
R
T
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
-
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
---
P
G
M
G
G
S
----
Q
R
L
T
---
R
A
I
-
G
K-
A
K
A
M
D
L
I
L
T
G
R
--
T
M
D
A
A
E
A
E
R
S
G
L
V
S
R
-
V
V
-
P
-
A
D
D
L
L
T
E
A
R
-----------------------------------------------------------------------------------------
A
T
A
T
T
I
S
Q
M
S
A
S
A
A
R
M
A
K
E
A
V
N
R
A
F
-
E
S
-
S
L
S
E
-
G
L
L
Y
E
R
R
L
F
H
S
A
F
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
--
A
P
Q
F
T
H
R
-------------------------------------
40
HHSearch
54.66
22%
-74
- C2 -
-
4KPK
1
?
A:
[37-292]
----------
Q
L
H
Y
L
S
C
T
L
N
G
G
V
A
Q
M
V
L
D
R
S
D
K
H
N
A
F
D
E
V
M
I
S
E
M
I
Q
V
L
E
H
F
K
R
N
E
Q
C
Q
I
L
L
L
K
A
N
G
-
K
N
F
S
A
G
A
D
L
N
W
M
R
K
Q
A
K
---
M
D
----
F
-------
E
Q
N
L
A
D
A
N
E
L
A
R
L
M
S
M
L
D
K
F
P
K
P
T
I
T
L
V
Q
G
A
A
F
G
G
A
L
G
L
I
C
C
S
D
I
A
I
A
N
-
E
R
A
S
F
C
L
S
E
V
K
L
G
L
I
---
P
A
V
I
-
S
----
P
Y
V
T
---
R
A
M
-
G
Q
-
R
A
A
R
R
Y
M
L
T
A
E
--
R
F
D
A
Q
K
A
L
E
L
Q
I
I
H
D
-
I
N
-
D
---
D
L
D
A
A
A
Q
P
F
I
-----------------------------------------------------------------------------------------
D
A
L
L
S
N
S
P
Q
G
M
A
W
V
K
C
L
L
S
S
L
E
-
D
G
-
V
I
D
Q
N
T
L
D
H
T
S
E
R
I
A
R
I
R
V
S
E
E
G
Q
E
G
L
N
A
F
F
E
K
R
--
S
P
Q
W
----------------------------------------
18
PsiBlast_PDB
54.35
29%
-142
- C2 -
-
3P5M
1
?
A:
[19-192]
-------------------------
I
R
L
D
R
P
E
K
L
N
A
V
D
T
P
M
L
E
E
L
S
V
H
I
R
D
A
E
A
D
E
S
V
R
A
V
L
L
-
T
G
A
G
R
A
F
C
S
G
G
D
---
L
---
D
T
---
A
G
A
---
A
-------
D
A
A
N
R
V
V
R
A
-------
I
T
S
L
P
K
P
V
I
A
G
V
H
G
A
A
V
G
F
G
C
S
L
A
L
A
C
D
L
V
V
A
A
-
P
A
S
Y
F
Q
L
A
F
T
R
V
G
L
M
---
P
D
G
G
A
S
----
A
L
L
P
L
L
I
G
-
R
-
A
--
R
T
S
R
M
A
-
M
T
A
E
--
K
I
S
A
A
T
A
F
E
W
G
M
I
S
H
-
I
T
-
S
-
A
D
E
Y
E
S
V
L
T
D
V
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
52.28
21%
-59
- C2 -
-
3GKB
2
?
B:
[8-261]
--------
Y
S
T
L
R
V
S
---
S
E
H
G
V
A
R
I
I
L
D
N
P
P
-
V
N
V
I
G
A
T
M
M
R
E
L
R
T
V
L
T
T
L
A
D
D
S
S
V
R
V
I
V
F
S
S
A
D
P
E
F
F
L
A
H
V
D
M
R
I
G
E
K
M
D
A
---
L
Q
E
L
--
A
-------
A
S
A
P
A
D
V
N
V
F
Q
A
V
G
E
L
I
R
H
Q
P
Q
V
T
I
V
K
L
A
G
K
A
R
G
G
G
A
E
F
V
A
A
A
D
M
A
F
A
A
A
E
T
A
G
L
G
Q
I
E
A
L
M
G
I
I
---
P
G
G
G
G
T
----
Q
Y
L
R
---
G
R
V
-
G
R
-
N
R
A
L
E
V
V
L
T
A
D
--
L
F
D
A
E
T
A
A
S
Y
G
W
I
N
R
-
A
L
-
P
A
D
-
E
L
D
E
Y
V
D
R
V
A
R
-
N
I
----
A
A
L
P
D
G
V
I
E
A
A
K
R
S
L
P
A
D
-------
D
-----
L
----
K
--
E
G
L
L
G
E
N
D
A
W
A
A
T
F
S
L
P
A
A
Q
Q
L
I
S
G
G
L
K
D
G
A
---------------------------------------------------------------------------------------------------------------------
45
HHSearch
50.88
22%
-75
- C2 -
-
3TLF
2
?
B:
[17-274]
------------------
V
D
G
H
T
A
T
I
T
L
N
R
P
D
A
L
N
A
L
S
P
H
M
I
T
E
L
R
A
A
Y
H
E
A
E
N
D
D
R
V
W
L
L
V
V
T
G
T
G
-
R
A
F
C
S
G
A
D
V
------------------PY-----
L
S
T
Y
D
Q
W
E
A
P
Q
E
G
T
P
P
F
R
T
M
A
K
P
V
L
T
A
V
N
G
I
C
C
G
A
G
M
D
W
V
T
T
T
D
I
V
I
A
S
-
E
Q
A
T
F
F
D
P
H
V
S
I
G
L
V
---
A
G
R
E
-
L
----
V
R
V
S
---
R
V
L
-
P
R
-
S
I
A
L
R
M
A
L
M
G
K
H
E
R
M
S
A
Q
R
A
Y
E
L
G
L
I
S
E
-
I
V
-
E
-
H
D
R
L
L
----------------------------------------------------------------------------------------
E
R
A
-
H
E
I
A
D
I
V
N
S
N
A
P
L
A
V
R
G
T
R
L
A
I
L
K
G
L
-
N
V
-
P
L
H
E
-
A
E
I
L
A
E
T
F
R
E
R
V
L
R
T
E
D
A
A
E
G
P
R
A
F
V
E
K
R
--
Q
P
N
W
Q
C
R
-------------------------------------
53
HHSearch
50.86
21%
-69
- C2 -
-
5JBX
1
?
B:
[10-260]
-----------------
D
A
R
G
P
I
E
I
W
T
I
D
G
E
S
R
R
N
A
I
S
R
A
M
L
K
E
L
G
E
L
V
T
R
V
S
S
S
R
D
V
R
A
V
V
I
T
G
A
G
D
K
A
F
C
A
G
A
D
L
K
E
R
A
T
M
A
E
-----------------
D
E
V
R
A
F
L
D
G
L
R
R
T
F
R
A
I
E
K
S
D
C
V
F
I
A
A
I
N
G
A
A
L
G
G
G
T
E
L
A
L
A
C
D
L
R
V
A
A
-
P
A
A
E
L
G
L
T
E
V
K
L
G
I
I
---
P
G
G
G
G
T
----
Q
R
L
A
---
R
L
V
-
G
P
-
G
R
A
K
D
L
I
L
T
A
R
--
R
I
N
A
A
E
A
F
S
V
G
L
A
N
R
-
L
A
-
P
E
G
-
H
L
L
A
V
A
Y
G
L
A
E
-----------------------------------------------------------------------------------------
S
V
V
E
N
A
P
I
A
V
A
T
A
K
H
A
I
D
E
G
T
-
G
L
-
E
L
D
D
-
A
L
A
L
E
L
R
K
Y
E
E
I
L
K
T
E
D
R
L
E
G
L
R
A
F
A
E
K
R
--
A
P
V
Y
K
G
--------------------------------------
47
HHSearch
49.70
20%
-65
- C2 -
-
3KQF
-
?
C:
[16-265]
-------------------
T
P
H
V
V
K
I
S
L
N
R
E
R
Q
A
N
S
L
S
L
A
L
L
E
E
L
Q
N
I
L
T
Q
I
N
E
E
A
N
T
R
V
V
I
L
T
G
A
G
E
K
A
F
C
A
G
A
D
L
K
E
R
A
G
M
N
E
---
E
--------------
Q
V
R
H
A
V
S
M
I
R
T
T
M
E
M
V
E
Q
L
P
Q
P
V
I
A
A
I
N
G
I
A
L
G
G
G
T
E
L
S
L
A
C
D
F
R
I
A
A
-
E
S
A
S
L
G
L
T
E
T
T
L
A
I
I
---
P
G
A
G
G
T
----
Q
R
L
P
---
R
L
I
-
G
V-
G
R
A
K
E
L
I
Y
T
G
R
--
R
I
S
A
Q
E
A
K
E
Y
G
L
V
E
F
-
V
V
-
P
-
V
H
L
L
E
E
K
----------------------------------------------------------------------------------------
A
-
I
E
I
A
E
K
I
A
S
N
G
P
I
A
V
R
L
A
K
E
A
I
S
N
G
I
-
Q
V
-
D
L
H
T
-
G
L
Q
M
E
K
Q
A
Y
E
G
V
I
H
T
K
D
R
L
E
G
L
Q
A
F
K
E
K
R
--
T
P
M
Y
K
G
E
-------------------------------------
44
HHSearch
49.52
22%
-52
- C2 -
-
3TLF
3
?
D:
[17-274]
------------------
V
D
G
H
T
A
T
I
T
L
N
R
P
D
A
L
N
A
L
S
P
H
M
I
T
E
L
R
A
A
Y
H
E
A
E
N
D
D
R
V
W
L
L
V
V
T
G
T
G
-
R
A
F
C
S
G
A
D
V
K
E
I
P
E
D
G
K
---
V
I
Y
---
E
RPY----
L
S
T
Y
D
Q
W
E
A
P
Q
E
G
T
P
P
F
R
T
M
A
K
P
V
L
T
A
V
N
G
I
C
C
G
A
G
M
D
W
V
T
T
T
D
I
V
I
A
S
-
E
Q
A
T
F
F
D
P
H
V
S
I
G
L
V
---
A
G
R
E
-
L
----
V
R
V
S
---
R
V
L
-
P
R-
S
I
A
L
R
M
A
L
M
G
K
HE
R
M
S
A
Q
R
A
Y
E
L
G
L
I
S
E
-
I
V
-
E
-
H
D
R
L
L
----------------------------------------------------------------------------------------
E
R
A
-
H
E
I
A
D
I
V
N
S
N
A
P
L
A
V
R
G
T
R
L
A
I
L
K
G
L
-
N
V
-
P
L
H
E
-
A
E
I
L
A
E
T
F
R
E
R
V
L
R
T
E
D
A
A
E
G
P
R
A
F
V
E
K
R
--
Q
P
N
W
Q
C
R
-------------------------------------
11
PsiBlast_PDB
48.72
27%
-111
- C2 -
-
3H81
1
ECHA8_MYCTU
A:
[23-210]
--------
T
Y
E
T
I
L
V
E
R
D
Q
R
V
G
--
I
I
T
L
N
R
P
Q
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
-
T
G
S
A
K
A
F
A
A
G
A
D
I
K
E
M
A
D
L
T
F
-------------------
A
D
A
F
T
A
D
F
F
A
T
W
G
K
L
A
A
V
R
T
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
-
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
---
P
G
M
G
G
S
Q
R
L
T
R
A
I
G
---
K
-
A
-
K
--
A
M
D
L
I
--
L
T
G
R
--
T
M
D
A
A
E
A
E
R
S
G
L
V
S
R
-
V
V
-
P
-
A
---
D
D
L
L
T
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
48.22
20%
-62
- C2 -
-
2ZQQ
-
AUHM_HUMAN
D:
[84-339]
-----------------
E
E
N
R
G
I
V
V
L
G
I
N
R
A
Y
G
K
N
S
L
S
K
N
L
I
K
M
L
S
K
A
V
D
A
L
K
S
D
K
K
V
R
T
I
I
I
R
S
E
V
P
G
I
F
C
A
G
A
D
L
K
E
R
A
K
M
S
S
---
S
--------------
E
V
G
P
F
V
S
K
I
R
A
V
I
N
D
I
A
N
L
P
V
P
T
I
A
A
I
D
G
L
A
L
G
G
G
L
E
L
A
L
A
C
D
I
R
V
A
A
-
S
S
A
K
M
G
L
V
E
T
K
L
A
I
I
---
P
G
G
G
G
T
----
Q
R
L
P
---
R
A
I
-
G
M-
S
L
A
K
E
L
I
F
S
A
R
--
V
L
D
G
K
E
A
K
A
V
G
L
I
S
H
-
V
L
-
E
-
Q
N
Q
E
G
D
---
A
A
---------------------------------------------------------------------------------
Y
R
K
A
-
L
D
L
A
R
E
F
L
P
Q
G
P
V
A
M
R
V
A
K
L
A
I
N
Q
G
M
-
E
V
-
D
L
V
T
-
G
L
A
I
E
E
A
C
Y
A
Q
T
I
P
T
K
D
R
L
E
G
L
L
A
F
K
E
K
R
--
P
P
R
Y
K
G
E
-------------------------------------
48
HHSearch
48.05
20%
-64
- C2 -
-
1HZD
-
AUHM_HUMAN
F:
[84-339]
-----------------
E
E
N
R
G
I
V
V
L
G
I
N
R
A
Y
G
K
N
S
L
S
K
N
L
I
K
M
L
S
K
A
V
D
A
L
K
S
D
K
K
V
R
T
I
I
I
R
S
E
V
P
G
I
F
C
A
G
A
D
L
K
E
R
A
K
M
S
S
---
S
--------------
E
V
G
P
F
V
S
K
I
R
A
V
I
N
D
I
A
N
L
P
V
P
T
I
A
A
I
D
G
L
A
L
G
G
G
L
E
L
A
L
A
C
D
I
R
V
A
A
-
S
S
A
K
M
G
L
V
E
T
K
L
A
I
I
---
P
G
G
G
G
T
----
Q
R
L
P
---
R
A
I
-
G
M-
S
L
A
K
E
L
I
F
S
A
R
--
V
L
D
G
K
E
A
K
A
V
G
L
I
S
H
-
V
L
-
E
-
Q
N
Q
E
G
D
---
A
A
---------------------------------------------------------------------------------
Y
R
K
A
-
L
D
L
A
R
E
F
L
P
Q
G
P
V
A
M
R
V
A
K
L
A
I
N
Q
G
M
-
E
V
-
D
L
V
T
-
G
L
A
I
E
E
A
C
Y
A
Q
T
I
P
T
K
D
R
L
E
G
L
L
A
F
K
E
K
R
--
P
P
R
Y
K
G
E
-------------------------------------
52
HHSearch
47.83
18%
-79
- C2 -
-
1DCI
4
ECH1_RAT
A:
[10-265]
------------------
A
Q
K
H
V
L
H
V
Q
L
N
R
P
E
K
R
N
A
M
N
R
A
F
W
R
E
L
V
E
C
F
Q
K
I
S
K
D
S
D
C
R
A
V
V
V
S
G
A
G
K
-
M
F
T
S
G
I
D
L
M
D
M
A
S
D
I
L
---
Q
P
P
---
G
DD
V
A
R
I
A
W
Y
L
R
D
L
I
S
R
Y
Q
K
T
F
T
V
I
E
K
C
P
K
P
V
I
A
A
I
H
G
G
C
I
G
G
G
V
D
L
I
S
A
C
D
I
R
Y
C
T
-
Q
D
A
F
F
Q
V
K
E
V
D
V
G
L
A
---
A
D
V
G
T
L
----
Q
R
L
P
---
K
V
I
-
G
N
R
S
L
V
N
E
L
T
F
T
A
R
--
K
M
M
A
D
E
A
L
D
S
G
L
V
S
R
-
V
F
-
P
D
K
D
V
M
L
N
A
A
F
A
L
A
A
-
D
I
----
S
S
K
S
P
V
A
V
Q
G
S
K
I
N
L
I
Y
S
R
D
----
H
S
-----
V
----
D
--
E
S
L
D
Y
M
A
T
W
N
M
S
M
L
Q
T
Q
D
I
I
K
S
V
Q
A
A
M
E
K
K
----------------------------------------------------------------------------------------------------------------------