@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VN94: (2017-11-13 )
MASRPVLATGITTELKIRGKSMNILTDKAHYESHLEAYIVQKLQAQGWVVGQSKNYHTEYALYPEDLITWIQATQPEKWEKLQALNGSNTEKRIIDRLDDELNKKGTIHIFRNGFSMAGAGTIDLSESAPEDGRNQAVIDRYNANILRVVPQLKYHPSKDAGILDLVFFINGLPMATVEIKTEFNQSLEDAIEQYKNDRKPIDPKTRRKEPLLTPKRGAIVHFALSESEIAMTTALDGESTYFLPFNKGNQGHAGNPPADVAKGEDYPVAYFWDYVCQRDNWLKIFHNFVYVEKKNKVDLYGNWTVQERLIFPRYHQFDAVNKIIADVQEKGVGLNYLCEHSAGSGKTSTISWVCHSLVRLRHNDGTPFYNSVIVVTDRTVLDNQLQEAIQQLDHQKGLIAAINRDDKEHAGKSKSKQLEDALLSNKQIIIVTIQTFPHVMEAILTNTSLSDRNYGIVIDEAHTSQTGSTASKLQATLALQSGEAMANLTVEELLEQIQKARVQSKNISHFAFTATPKHSTKMLFGRTKNGEPASDDNLPEPFHLYPQRQAIEEGFILDVLQGYVPYKTAFKLGGEAVDDDKRVNSKAAKKALARWMALHATNVTQKVQFIIQHFHHNVANLLNGQAKAMIVTSSRPAAARYKIALEKYIDDNPEYSAYRVLVAFSGKLTGKQISHEADGDSENGVLFQVGEDAEFTEANMNADAPNSDLRIAFDRPEYRLMVVANKFQTGFDQPKLCAMYIDKVIANEVEVVQTLSRLNRTTTGKDQTFVIDFVNDPEWILKCFKKYDNGAKMVDVQDPNVVYTIKDNIEELDLITEDDLEEFKAARFKTIRDISNHDFKETTHPDLFKATDRVARLFNQKLKMLKQAIELQETAFDQAKADGNDEGAEKAEFERKQLDVELQTLMRFKGNLDKFSRIYSYVAQLIDFGDPELENFSAFTKLLSKRLNGMSAKEIDISGLVLTGFGIFKKKLKTDDTDHPEADEPQPLAPIQGTANGDLQPTKMTYLKEVIELIAQTFGDISTREEQVVYINHLVTILRNNDVVMAQIENNPESTALQGNLPSATKGAIIQALTSHQDLSALLLKTDAQAMQNVIKVLYKLLKDGETIDVHRLT
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80......---------..90........100.......110.......120.......130..--.....140.--......150.......160--........170.......180.......190.......200.......210.......220.......230.......240.--......250.......260.......270.......280.......290.........300....---...310.......320.......330.....-------..340.......350.......360.--.-.----....370.......380.......390--.--------....-.-.-400.......---.----410.........420--.--------......430.......440---.....-..450-........460......-.-470---........480.......490.......500....-...510....-.-..520-------------------.......530--........540.....-.-.550.-......560.......570.......580.......590.......600.......610...---....620.....--..630.......----640.......650....---..-.660.......670.---.....------.680.......690....---...700.....-----..710...-----....720.......730..---.....740--......------..750.......760.......770......--..780.......790.......800-.........810.......820.......830.......840.......850.......860--........870.......880.....--------..890.......900.......910........920......-.930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......---------1040..--..---..1050......1060......1070......1080......1090......1100......1110..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MASR
P
V
L
ATG
I
T
T
E
L
K
I
RGKS
M
N
ILTD
K
A
H
Y
E
S
H
L
E
A
Y
I
V
Q
K
L
QAQG
W
V
VGQSKNYHTEYAL
Y
P
E
D
L
I
T
W
I
QATQ
P
E
K
W
E
K
L
QALNG---------S
N
T
E
K
R
I
I
D
R
L
D
D
E
LNKK
G
T
I
H
I
FRNGFSMAG
A
G
T
I
DLSESAPEDGR--N
Q
A
V
I
DRYN--A
N
I
L
R
VVPQLKYHPSKDA---
G
I
L
D
L
V
F
F
INGL
P
M
A
T
V
E
I
K
T
E
F
N
Q
S
L
E
D
A
I
E
Q
Y
KNDRKPIDPKTRRKEPLLTPKR
G
A
I
V
H
F
ALSES
E
I
A
M
T
T
ALDGE
S
T
Y
F
--
L
PFNKGNQGHAGNPPADVAKGEDY
P
V
A
Y
F
W
D
Y
V
CQRD
N
W
L
K
I
F
H
N
F
V
--
Y
V
E
KK
N
K
V
D
L
YGN
W
T
V
---
Q
E
R
L
IFPR
Y
H
Q
F
D
A
V
N
K
I
I
A
D
V
Q
E
KGVGL
N
Y
-------
L
CEHSAGSGK
T
S
T
I
S
W
V
C
H
S
L
V
R
L
RH--N-D----GTPFY
N
S
V
I
V
V
TD
R
T
V
L
D
N
Q
L
Q
E
A
I
Q
Q
--
L
--------
D
HQK-G-
L
-
I
-
A
AINRD
D
K
---
E
----H--AGKS
K
S
K
Q
L
E
D
A
--
L
--------LSNK
Q
I
I
I
V
T
I
Q
T
F
P
H
V
M
E
---
A
I
LTN-TSLS--DRN
Y
G
I
V
I
DEAHTSQTG-S-
T
A
----
S
K
L
Q
A
T
L
A
LQSG
E
A
M
A
N
L
T
V
E
E
L
L
E
Q
I
Q
K
A
R
VQSK-NI
S
H
F
A
F
TAT-P-KHS
T
K
-------------------
M
L
F
G
RTKNG---EPASDDNLPEPFHLY
P
-
Q
-
R
Q
A
I
E-E
G
F
I
L
D
V
L
QGYV
P
Y
K
T
A
F
KLGGEAVDDDKRV
N
S
K
A
A
K
K
A
L
A
R
W
M
A
L
H
AT
N
V
T
Q
K
V
Q
F
I
I
Q
H
F
---
H
H
N
V
A
N
L
LNGQ
A
--
K
A
M
I
V
TSSRPA
A
----
A
R
Y
K
I
A
L
E
K
YIDDNPEY---
S
A
-
Y
R
V
L
V
A
FSGKLTGKQ---ISHEA------DGDSEN
G
V
L
F
QVGEDAEF---TEANMNADAPN-----S
D
L
R
I
A
FD-----RP
E
Y
R
L
M
V
V
AN
K
F
QTGFDQ---
P
K
L
C
A
M
Y
---
I
D
K
V
I
A------
N
E
V
E
V
V
Q
T
L
S
R
LNRTTTGKD
Q
T
F
V
-
I
D
FVND--
P
E
W
I
L
K
C
F
K
K
YDNG
A
K
M
V
DVQDP---
N
V
V
Y
TIKDN
I
E
E
LDLI
T
E
D
D
L
E
E
F
K
A
A
R
F
K
T
I
R
D
ISNHDFKETTH
P
D
L
F
K
A
T
D
R
V
A
R
L
F
N
Q
---
K
L
K
M
L
K
Q
A
I
E
L
Q
E
T
A
FDQAKADGNDE--------G
A
E
K
A
E
F
E
R
K
Q
L
D
V
E
L
Q
T
L
M
R
FKG-
N
L
D
K
F
S
R
I
Y
S
Y
V
A
Q
L
ID-FGDP
E
L
E
N
F
S
A
F
T
K
L
L
S
K
RLNGMSA
K
E
I
D
IS
G
L
V
L
T
G
F
G
I
F
K
K
K
LKTDDTDHPEADEPQPLAPIQGTANGDLQP
T
K
M
T
Y
L
K
E
V
I
E
L
I
A
Q
T
FGDISTRE
E
Q
V
V
Y
I
N
H
L
V
T
I
L---------RNN
D
V
V
--
M
A
---
Q
IENNPESTALQGNLPSA
T
K
G
A
I
I
Q
A
L
T
SHQ
D
L
S
A
L
L
L
KT
D
A
Q
A
M
Q
N
V
I
K
V
L
Y
K
L
LKDG
E
T
I
D
V
HRLT
55
Fugue
62.06
15%
15
- C2 -
-
5AOR
3
MLE_DROME
A:
[119-1158]
-----------------
L
G
E
A
Y
R
P
L
E
Q
R
D
M
N
E
A
--
E
A
F
D
V
N
A
A
I
H
G
N
W
T
I
E
N
A
K
E
R
L
N
I
Y
K
Q
T
N
N
I
-------
R
D
D
Y
K
Y
T
P
V
----
G
---------
P
E
H
A
R
S
F
L
A
E
L
S
I
Y
V
P
A
L
N
R
T
V
T
A
R
E
S
G
S
N
K
K
S
A
S
K
S
C
A
L
S
L
V
R
Q
L
F
--
H
L
N
V
I
E
P
F
S
--
G
T
-
L
K
K
D
E
Q
L
K
P
Y
P
-----------------------
V
K
L
S
P
N
L
I
N
K
I
D
E
V
I
K
G
L
--
D
L
P
V
V
N
P
R
N
I
K
I
E
--------------
L
D
G
P
P
I
P
L
I
V
N
L
S
R
I
E
S
S
V
--
I
P
W
A
P
P
Q
A
N
W
N
T
W
H
A
C
N
I
D
E
G
E
L
A
T
T
--------
S
I
D
D
L
S
M
D
Y
E
R
S
L
--
R
D
R
R
Q
N
D
N
E
Y
R
Q
F
L
E
F
---
R
E
K
L
-----
P
I
A
A
M
R
S
E
I
L
T
A
I
N
D
N
P
V
V
I
I
R
-------
G
---
N
T
G
C
G
K
T
T
Q
I
---
A
Q
Y
I
L
D
D
Y
I
--
C
-
S
----
G
Q
G
G
Y
A
N
I
Y
V
T
Q
P
R
R
I
S
A
I
S
V
A
E
R
V
A
R
E
R
C
--------
E
Q
L
G
-
D
-
T
-
V
-
G
Y
S
V
R
F
E
S
---
V
----
F
--
P
R
P
Y
G
----------------------
A
I
L
F
C
T
V
G
V
L
L
R
K
L
E
---
A
G
L
R
G
-
V
S
--------
H
I
I
V
D
E
I
H
E
---
R
-
D
-
V
N
----
S
D
F
L
L
V
I
L
R
D
M
V
D
T
Y
P
D
L
----------
H
V
I
L
M
S
A
-
T
I
D
T
T
K
F
S
K
Y
-
F
G
I
C
P
V
L
-------------------
E
V
P
G
R
A
F
P
V
---
Q
Q
F
F
L
E
D
I
I
Q
M
T
D
F
V
P
-
S
-
A
E
S
R
R
-
K
R
K
E
V
E
D
E
E
Q
L
L
S
E
D
K
----
D
E
A
E
I
N
Y
N
K
V
C
E
D
K
Y
S
Q
K
T
R
N
A
M
A
M
L
S
E
S
D
V
S
--
F
E
L
L
E
A
L
L
---
M
H
I
K
S
K
N
I
P
G
-----
A
I
L
V
F
---
L
P
G
----
W
N
L
I
F
A
L
M
K
F
L
Q
N
T
N
I
F
GDT
S
Q
-
Y
Q
I
L
P
C
H
S
Q
I
P
R
D
E
Q
---
R
K
V
F
E
------
P
V
P
E
G
V
T
K
I
I
L
S
T
N
I
A
E
T
---
S
-------
I
T
I
-----
D
D
I
V
F
V
I
D
IC---
K
A
R
M
K
L
F
T
S
H
N
N
L
T
S
Y
A
T
V
W
A
S
K
T
N
L
E
Q
R
K
G
R
A
G
R
V
R
P
------
G
F
C
F
T
L
C
S
R
A
R
F
Q
A
L
E
D
N
L
T
P
E
M
F
-
R
T
P
L
H
E
--
M
A
L
T
I
K
L
L
R
L
G
S
I
H
H
F
L
S
K
A
L
E
P
PP
V
D
A
V
I
E
A
E
V
L
L
R
E
M
R
C
L
D
A
N
D
-
E
L
T
P
L
G
R
L
L
A
R
L
P
I
E
P
R
L
G
K
M
M
V
L
G
A
V
F
G
C
A
D
L
M
A
I
M
A
S
Y
S
S
T
F
S
E
V
F
S
L
D
I
G
Q
R
R
L
A
N
H
Q
K
A
L
S
G
T
K
C
S
D
H
V
A
M
I
V
A
S
Q
M
W
R
R
E
K
Q
R
G
E
H
M
E
A
R
F
C
D
W
K
G
L
Q
M
S
T
M
N
V
I
W
D
A
K
Q
Q
L
L
D
L
L
Q
Q
A
G
F
P
E
E
C
M
I
S
H
E
V
D
E
R
I
D
G
-
D
D
P
V
L
D
V
S
-
L
A
L
L
C
L
G
L
Y
P
N
I
C
V
H
K
E
K
R
K
V
L
T
T
E
S
K
A
A
L
L
H
K
T
S
V
N
C
S
N
L
A
V
T
F
P
Y
P
---
F
F
V
F
G
E
K
I
R
T
R
A
V
S
C
K
Q
L
S
M
V
S
P
L
Q
V
I
L
FGSR
K
I
D
L
A
A
N
N
I
V
R
--
V
D
NWL
N
F
D
I
E
P
E
L
A
A
K
I
G
A
L
K
P
A
L
E
D
L
I
T
V
A
C
D
N
P
S
D
I
--
L
R
L
E
E
P
Y
A
Q
L
V
K
V
V
K
D
L
C
V
--
K
S
A
G
D
F
G
L
Q
R
--
1
PsiBlast_PDB
61.44
20%
42
- C2 -
-
4BEC
1
T1R1_ECOLX
A:
[28-704]
--------------------------
D
S
Y
Q
S
E
S
D
L
E
R
E
L
I
Q
D
L
R
N
Q
G
Y
E
F
I
S
V
K
S
Q
---------------
S
A
M
L
A
N
V
R
E
Q
L
Q
N
L
N
G
V
V
F
N
D
S
E
W
R
R
F
T
E
Q
Y
L
D
N
P
S
D
G
I
L
D
K
T
R
K
I
H
I
D
Y
------------
I
C
D
F
I
F
D
D
E
R
L
E
N
I
Y
L
I
D
K
K
N
LM
R
N
K
V
Q
I
I
Q
Q
-------------
R
Y
D
V
T
I
L
V
N
G
L
P
L
V
Q
I
E
L
K
----------------------------------
K
R
G
V
A
I
R
E
A
F
N
Q
I
H
R
Y
S
K
E
S
F
N
S
E
N
S
L
F
KY
L
Q
L
F
V
I
S
N
G
T
D
T
R
Y
F
A
N
T
T
K
R
D
A
N
S
F
D
F
T
M
N
W
A
K
S
D
N
T
L
I
K
D
L
K
D
F
T
A
T
C
F
Q
K
H
T
L
L
N
V
L
V
N
Y
S
V
F
D
S
S
Q
T
L
L
V
M
R
P
Y
Q
I
A
A
T
E
R
I
L
W
K
I
K
S
S
F
T
A
K
N
W
SKPES
G
G
Y
I
W
H
T
T
G
S
G
K
T
L
T
------
S
F
K
A
A
R
L
--
A
-
T
----
E
L
D
F
I
D
K
V
F
F
V
V
D
R
K
D
L
D
Y
Q
T
M
K
E
Y
Q
R
--
F
SPDSVNGS
E
N
T
A
-
G
-
L
-
K
-
R
N
L
D
K
D
D
N
--------------------------------------
K
I
I
V
T
T
I
Q
K
L
N
N
L
M
K
---
A
-
E
S
D
-
L
P
V
Y
--
N
Q
Q
V
V
F
I
F
D
E
C
H
R
S
Q
F
G
---------------------
E
A
Q
K
N
L
------------
K
K
K
F
K
-
R
Y
Y
Q
F
G
F
T
G
T
-
P
--------------------------
I
F
P
E
N
A
L
G
---
S
E
T
T
A
S
V
F
G
R
E
L
H
S
Y
V
-
I
-
T
D
A
I
R
-
D
E
K
V
L
K
F
K
V
D
Y
N
D
V
R
P
Q
F
K
-
S
L
E
T
E
T
D
E
K
K
L
S
A
A
E
N
Q
Q
A
F
-----
L
H
P
M
R
I
Q
E
I
T
Q
Y
I
L
N
N
F
---
R
Q
K
T
H
R
T
F
P
G
S
K
G
F
N
A
M
L
A
V
S
S
V
D
A
A
K
A
Y
Y
A
T
F
K
R
L
Q
E
E
A
A
N
K
S
A
T
Y
---
K
P
-
L
R
I
A
T
I
F
S
F
A
-----IG
E
I
S
D
E
T
FDTSAM
D
S
S
A
K
E
F
L
D
A
A
I
R
E
Y
N
S
H
---
F
K
T
N
F
S
T
D
S
N
G
F
Q
N
Y
Y
R
D
L
A
Q
R
V
K
-----
N
Q
D
I
D
L
L
I
V
V
G
M
F
L
T
G
F
D
A
---
P
T
L
N
T
L
F
---
V
D
K
N
L
R
------
Y
H
-
G
L
M
Q
A
F
S
R
T
N
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
43.93
16%
-29
- C2 -
-
5ELX
2
DBP5_YEAST
A:
[23-368]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
-----
P
P
R
N
M
-------
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
N
P
E
D
------------
A
S
P
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
--
M
--------
G
K
F
T
-
K
-
I
-
T
-
S
Q
L
I
V
-------------------
P
D
S
F
E
K
N
--
K
--------
Q
I
N
A
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
---
R
K
----
L
M
Q
L
--
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
-
Q
G
L
G
----
D
Q
C
I
R
V
K
-----------------------
R
F
L
P
K
-
D
T
Q
L
V
L
F
S
A
T
-
F
-
A
D
A
V
R
-------------------
Q
Y
A
K
K
I
V
P
-----------
N
---
A
N
T
L
E
-
L
-
Q
T
----
N
E
V
N
V
D
A
I
K
-----
Q
L
Y
M
D
C
K
N
----------------------------
E
A
D
K
F
D
V
L
T
E
L
Y
---
G
L
------
M
T
I
G
--
S
S
I
I
F
V
A
T
K
K
T
A
----
N
V
L
Y
G
K
L
K
S
E
-----
G
H
--------
E
V
S
I
L
H
G
D
L
Q
T
Q
---------------------------------------------
E
R
-----
D
R
L
I
D
D
F
R
-----
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
---
P
T
V
S
M
V
V
---
N
Y
D
L
P
T
LANGQA
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
---
K
G
V
A
-
I
S
F
V
H
D
K
N
S
F
N
I
L
S
A
I
Q
K
Y
F
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
43.89
21%
-131
- C2 -
-
5JAJ
6
?
A:
[9-163]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
H
G
Y
Q
L
E
A
V
A
P
A
L
R
-------
G
R
N
S
-------
I
V
W
L
P
T
G
A
G
K
T
R
A
A
V
H
V
C
R
R
H
L
E
G
R
R
-------------
G
G
R
V
A
V
L
V
N
K
V
H
L
V
Q
Q
H
L
E
K
E
F
H
--
V
--------
L
R
D
A
-
F
-
K
-
V
-
T
A
V
S
G
D
S
----------------
S
H
K
C
F
F
G
Q
--
L
--------
A
K
G
S
D
V
V
I
C
T
A
Q
I
L
Q
N
A
L
L
---
S
G
E
E
E
A
R
V
E
L
--
T
D
F
S
L
L
V
I
D
E
C
H
H
T
Q
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
42.68
22%
-121
- C2 -
-
5JB2
3
?
A:
[7-148]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
H
G
Y
Q
L
E
A
V
A
P
A
L
R
-------
G
R
N
S
-------
I
V
W
L
P
T
G
A
G
K
T
R
A
A
V
H
V
C
R
R
H
L
E
G
R
R
-------------
G
G
R
V
A
V
L
V
N
K
V
H
L
V
Q
Q
H
L
E
K
E
F
H
--
V
--------
L
R
D
A
-
F
-
K
-
V
-
T
A
V
S
G
D
S
----------------
S
H
K
C
F
F
G
Q
--
L
--------
A
K
G
S
D
-
V
I
C
T
A
Q
I
L
Q
N
A
L
L
---
S
G
E
E
E
A
R
V
E
L
--
T
D
F
S
L
L
V
I
D
E
C
H
H
T
Q
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
41.68
14%
-1
- C2 -
-
3I5X
2
MS116_YEAST
A:
[54-562]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
L
I
H
V
P
K
E
D
N
S
K
E
--
V
T
L
D
S
L
L
E
E
G
V
L
D
K
E
I
---
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
E
D
H
D
V
-------
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
N
T
K
--
F
-
D
----
S
Q
Y
M
V
K
A
V
I
V
A
P
T
R
D
L
A
-
L
Q
I
E
A
E
V
K
K
--
I
--------
H
D
M
N
-------
Y
G
L
K
K
Y
A
C
---
V
----
S
--
L
V
G
G
T
D
F
R
A
A
M
N
--
K
--------
M
N
K
L
R
P
N
I
V
I
A
T
--
P
G
R
L
I
---
D
V
L
E
K
-
Y
S
N
K
FF
R
F
V
D
Y
K
V
L
D
E
--------------------
A
D
R
L
L
E
I
G
F
---
R
D
D
L
E
T
I
S
G
I
L
N
E
K
N
S
K
S
A
D
N
I
K
T
L
L
F
S
A
T
-
L
-
D
D
K
V
Q
-------------------
K
L
A
N
N
I
M
N
-----------
K
K
E
C
L
F
L
D
T
-
V
-
D
K
N
-
E
-
P
E
A
H
E
R
I
D
Q
S
V
V
I
S
E
K
F
----------------------------------
A
N
S
I
F
A
A
V
E
H
I
---
K
K
Q
I
K
E
R
-
D
S
N
Y
--
K
A
I
I
F
A
P
T
V
K
F
T
----
S
F
L
C
S
I
L
K
N
E
F
K
K
D
L
P
----------
I
L
E
F
H
G
K
I
T
---------------------------------------------
Q
N
K
R
-----
T
S
L
V
K
R
F
K
-----
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
---
P
N
V
H
E
V
L
---
Q
I
G
V
P
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
--
G
K
E
G
S
S
V
-
L
F
I
C
K
D
--
E
L
P
F
V
R
E
L
E
D
A
K
N
-
I
V
I
A
K
Q
E
K
Y
---
E
P
S
E
E
I
K
S
E
V
L
E
A
---
V
T
E
E
P
E
D
I
S
D
I
V
I
S
L
I
S
S
Y
R
S
C
I
K
E
Y
R
--
F
S
E
R
R
I
L
P
E
I
A
S
T
Y
G
V
---
L
L
N
D
P
Q
L
K
I
P
V
S
R
R
F
L
D
K
L
G
L
S
R
S
P
I
--------
G
K
A
M
F
E
I
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
41.62
16%
-20
- C2 -
-
5SUP
2
SUB2_YEAST
A:
[27-355]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
P
S
E
V
Q
Q
H
T
I
P
Q
S
I
H
-------
G
T
D
V
-------
L
C
Q
A
K
S
G
L
G
K
T
A
V
F
V
L
S
T
L
Q
Q
L
D
P
V
P
------------
G
E
V
A
V
V
V
I
C
N
A
R
E
L
A
Y
Q
I
R
N
E
Y
L
R
--
F
--------
S
K
Y
M
P
D
V
K
-
T
-
A
V
F
Y
G
G
T
-------------
P
I
S
K
D
A
E
L
L
K
N
--
K
--------
D
T
A
P
H
I
V
V
A
T
P
G
R
L
K
A
L
V
R
---
E
K
----
Y
I
D
L
--
S
H
V
K
N
F
V
I
D
E
C
D
K
V
L
E
E
L
D
-
M
R
----
R
D
V
Q
E
I
F
R
-----------------------
A
T
P
R
-
D
K
Q
V
M
M
F
S
A
T
-
L
-
S
Q
E
I
R
-------------------
P
I
C
R
R
F
L
Q
-------------
N
P
L
E
I
F
V
-
D
-
D
E
--
A
-
K
L
T
-------
L
H
G
L
Q
Q
Y
Y
I
K
L
E
------------------------
E
R
----
E
K
N
R
K
L
A
Q
L
L
---
D
D
------
L
E
F
N
--
Q
V
I
I
F
V
K
S
T
T
R
A
----
N
E
L
T
K
L
L
N
A
S
-----
N
F
--------
P
A
I
T
V
H
G
H
M
K
Q
E
---------------------------------------------
E
R
-----
I
A
R
Y
K
A
F
K
-----
D
F
E
K
R
I
C
V
S
T
D
V
F
G
R
G
I
D
I
---
E
R
I
N
L
A
I
---
N
Y
D
L
T
N
------
E
A
D
Q
Y
L
H
R
V
G
R
A
G
R
F
G
T
---
K
G
L
A
-
I
S
F
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
40.64
14%
-24
- C2 -
-
2DB3
2
VASA1_DROME
A:
[77-405]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
-------
G
R
D
L
-------
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
--
H
-
E
----
L
E
L
G
R
P
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
--
F
--------
A
F
E
S
-
Y
-
L
K
I
-
G
I
V
Y
G
G
T
----------------
S
F
R
H
Q
N
E
C
--
I
--------
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
---
R
T
----
F
I
T
F
--
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
M
-
G
-
F
S
----
E
D
M
R
R
I
M
T
H
V
---------------------
T
M
R
P
-
E
H
Q
T
L
M
F
S
A
T
-
F
-
P
E
E
I
Q
-------------------
R
M
A
G
E
F
L
-----------------
K
N
Y
V
-
F
V
A
I
G
I
V
-
G
G
A
C
S
D
V
-------
K
Q
T
I
Y
--
E
V
---------------------
N
K
-----
Y
A
K
R
S
K
L
I
E
I
L
---
S
-------
E
Q
A
D
--
G
T
I
V
F
V
E
T
K
R
G
A
----
D
F
L
A
S
F
L
S
E
K
-----
E
F
--------
P
T
T
S
I
H
G
D
R
L
Q
S
---------------------------------------------
Q
R
-----
E
Q
A
L
R
D
F
K
-----
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
---
K
N
I
K
H
V
I
---
N
Y
D
M
P
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
---
N
G
R
A
-
T
S
F
F
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
40.56
15%
-21
- C2 -
-
4LJY
3
PRP5_YEAST
A:
[73-416]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
P
I
Q
S
Q
A
L
P
A
I
M
S
-------
G
R
D
V
-------
I
G
I
S
K
T
G
S
G
K
T
I
S
Y
L
L
P
L
L
R
Q
V
K
A
Q
R
--
P
L
S
----
K
H
E
T
G
P
M
G
L
I
L
A
P
T
R
E
L
A
L
Q
I
H
E
E
V
T
K
--
F
--------
T
E
A
D
T
S
I
R
-
S
-
V
C
C
T
G
G
S
----------------
E
M
K
K
Q
I
T
D
--
L
--------
K
R
G
T
E
I
V
V
A
T
P
G
R
F
I
D
I
L
T
---
L
N
D
G
K
-
L
L
S
T
--
K
R
I
T
F
V
V
M
D
E
A
D
R
L
F
D
L
-
G
-
F
E
----
P
Q
I
T
Q
I
M
K
T
-----------------------
V
R
P
-
D
K
Q
C
V
L
F
S
A
T
-
F
-
P
N
K
L
R
-------------------
S
F
A
V
R
V
L
H
-----------
S
P
I
-
S
I
T
I
N
-
S
-
K
G
M
V
N
-
E
N
V
K
----
Q
-------
K
F
R
I
C
H
S
--
E
-
D
E
K
F
------
D
N
L
V
Q
L
I
H
E
R
S
E
F
F
D
E
V
Q
-
S
------------------
D
A
--
K
A
I
I
F
V
S
S
Q
N
I
C
----
D
F
I
S
K
K
L
L
N
-----
A
G
I
--------
V
T
C
A
I
H
A
G
K
P
Y
Q
---------------------------------------------
E
R
-----
L
M
N
L
E
K
F
K
-----
R
E
K
N
S
I
L
L
C
T
E
V
L
S
R
G
L
N
V
---
P
E
V
S
L
V
I
---
I
Y
N
A
V
K
------
T
F
A
Q
Y
V
H
T
T
G
R
T
A
R
G
S
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
39.75
17%
3
- C2 -
-
4XQK
-
?
A:
[175-631]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
K
L
R
D
Y
Q
Q
T
A
K
E
N
A
L
A
H
F
K
E
---
N
D
R
G
-------
Q
L
I
M
A
P
G
T
G
K
T
F
T
S
L
K
I
S
E
A
L
S
K
D
K
D
------------
G
P
F
K
V
L
Y
L
V
P
S
I
Q
L
L
T
Q
T
L
R
G
W
N
N
--
D
--------
T
E
L
T
-
M
T
S
-
M
A
V
T
S
-----T
E
D
I
K
ASD
I
GY
P
A
T
T
S
S
K
K
I
L
Q
N
--
W
H
D
F
E
S
LPK
Q
T
D
M
L
V
V
F
S
T
Y
Q
S
I
E
V
I
G
E
---
A
Q
----
K
E
G
F
--
P
E
F
D
F
I
I
S
D
E
A
H
R
T
T
G
A
-
H
-
E
A
AKE
A
S
A
F
S
K
V
H
S
N
----------------------
N
N
V
K
-
G
L
K
R
M
Y
Q
T
A
T
-
P
-
K
I
Y
G
E
S
AKKNAKDKSILLSSMDDE
S
K
Y
G
E
-----------------
V
F
F
R
M
G
-
F
-
G
Q
A
V
S
-
R
D
I
L
T
D
Y
K
V
M
V
L
A
V
D
E
A
-
A
I
Q
K
D
M
---
Q
R
T
L
A
D
P
E
--
N
---
G
L
N
I
D
D
V
G
R
I
V
G
I
W
N
G
M
M
R
R
N
GYK-
K
N
S
P
Y
D
G
A
P
L
E
--
R
A
I
A
F
T
R
T
I
E
E
S
----
K
K
V
S
S
Q
F
E
E
V
V
N
E
-
Y
I
S
-----
I
H
L
S
M
R
H
A
D
G
Q
M
N
---------------------------------------------
A
L
Q
K
-----
G
E
V
L
D
W
L
A
NPNKP
A
D
E
A
R
I
V
S
N
V
R
F
L
T
E
G
I
D
I
---
P
T
L
D
A
V
I
---
F
L
S
P
K
K
------
S
Q
V
D
I
V
Q
A
V
G
R
I
M
R
K
A
E
G
K
D
Y
G
Y
I
-
I
L
P
I
V
I
--
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
39.64
17%
-38
- C2 -
-
1HV8
-
H669_METJA
A:
[28-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
D
------
E
Y
N
I
-------
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
L
V
N
E
N
N
-------------
G
I
E
A
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
--
L
--------
K
G
N
K
-
N
L
K
-
I
-
A
K
I
Y
G
G
K
----------------
A
I
Y
P
Q
I
K
A
--
L
---------
K
N
A
N
I
V
V
G
T
P
G
R
I
L
D
H
I
N
---
R
G
----
T
L
N
L
--
K
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
N
M
-
G
-
F
I
----
K
D
V
E
K
I
L
N
-----------------------
A
C
N
K
-
D
K
R
I
L
L
F
S
A
T
-
M
-
P
R
E
I
L
-------------------
N
L
A
K
K
Y
-----------------
M
G
D
Y
S
-
F
-
I
K
A
K
----
I
N
A
N
I
E
Q
S
------
Y
V
E
V
N
E
-------------------------
N
----
E
R
F
E
A
L
C
R
L
L
---
K
-------
N
K
E
F
--
Y
G
L
V
F
C
K
T
K
R
D
T
----
K
E
L
A
S
M
L
R
D
I
-----
G
F
--------
K
A
G
A
I
H
G
D
L
S
Q
S
---------------------------------------------
Q
R
-----
E
K
V
I
R
L
F
K
-----
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
---
N
D
L
N
C
V
I
---
N
Y
H
L
P
Q
------
N
P
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
38.20
14%
-42
- C2 -
-
1S2M
-
DHH1_YEAST
A:
[67-378]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
-------
G
R
D
I
-------
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
K
P
K
L
------------
N
K
I
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
--
L
--------
G
K
H
C
-
G
-
I
S
C
-
M
V
T
T
G
G
T
---------------
N
L
R
D
D
I
L
R
---
L
--------
N
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
L
A
S
---
R
K
----
V
A
D
L
--
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
R
-
D
-
F
K
----
T
I
I
E
Q
I
L
S
-----------------------
F
L
P
P
-
T
H
Q
S
L
L
F
S
A
T
-
F
-
P
L
T
V
K
-------------------
E
F
M
V
K
H
L
H
-------------
K
P
Y
E
I
N
L
-
M
-
E
------
E
L
T
L
K
------
G
I
T
Q
Y
Y
A
F
V
E
E
------------------------
R
----
Q
K
L
H
C
L
N
-
T
L
---
F
S
-----
K
L
Q
I
N
--
Q
A
I
I
F
C
N
S
T
N
R
V
----
E
L
L
A
K
K
I
T
D
L
-----
G
Y
--------
S
C
Y
Y
S
H
A
R
M
K
Q
Q
---------------------------------------------
E
R
-----
N
K
V
F
H
E
F
R
-----
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
---
Q
A
V
N
V
V
I
---
N
F
D
F
P
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
38.14
15%
-27
- C2 -
-
5IVL
-
?
B:
[24-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
T
P
I
Q
A
K
T
I
P
L
S
L
Q
-------
N
K
D
V
-------
I
G
Q
A
Q
T
G
T
G
K
T
A
A
F
G
I
P
I
V
E
K
V
D
V
K
N
------------
G
A
I
Q
A
L
V
V
A
P
T
R
E
L
A
I
Q
V
S
E
E
L
Y
K
--
I
--------
G
A
V
K
-
R
-
V
R
V
-
L
P
I
Y
G
G
Q
----------------
D
I
E
R
Q
I
R
A
--
L
--------
K
K
H
P
H
V
I
V
G
T
P
G
R
I
I
D
H
I
N
---
R
G
----
T
L
R
L
--
E
H
V
H
T
V
V
L
D
E
A
D
E
M
L
---
G
-
F
I
----
E
D
I
E
A
I
L
S
H
-----------------------
V
P
A
-
E
R
Q
T
L
L
F
S
A
T
-
M
-
P
D
P
I
R
-------------------
R
I
A
E
R
F
M
N
-----------
E
P
E
-
L
V
K
V
K
-
A
-----------
V
P
N
------
I
Q
Q
Y
Y
-------------------------
L
E
V
H
E
K
---
K
K
F
D
I
-
L
T
R
L
---
L
D
-----
I
Q
A
P
E
--
L
A
I
V
F
G
R
T
K
R
R
V
----
D
E
L
A
E
A
L
N
L
R
-----
G
Y
--------
A
A
E
G
I
H
G
D
L
S
Q
A
---------------------------------------------
K
R
-----
L
S
V
L
R
K
F
K
-----
E
G
A
I
E
I
L
V
A
T
D
V
A
A
R
G
L
D
I
---
S
G
V
T
H
V
Y
---
N
F
D
I
P
Q
------
D
P
E
S
Y
V
H
R
I
G
R
T
G
R
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
37.65
13%
-48
- C2 -
-
2J0U
-
IF4A3_HUMAN
A:
[22-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
-------
G
R
D
V
-------
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
V
S
V
L
Q
C
L
D
I
Q
V
------------
R
E
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
V
Q
K
G
L
L
A
--
L
--------
G
D
Y
M
-
N
-
V
-
Q
C
H
A
C
I
G
G
----------------
T
N
V
G
E
D
I
R
K
--
L
--------
D
Y
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
---
R
R
----
S
L
R
T
--
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
K
-
G
-
F
K
----
E
Q
I
Y
D
V
Y
R
-----------------------
Y
L
P
P
-
A
T
Q
V
V
L
I
S
A
T
-
L
-
P
H
E
I
L
-------------------
E
M
T
N
K
F
M
T
-------------
D
P
I
R
I
L
V
-
K
-
R
D
E
L
----
T
L
E
G
I
K
------
Q
F
F
V
A
V
E
------------------------
R
E
E
----
W
K
F
D
T
L
C
D
L
Y
---
D
---------
I
T
--
Q
A
V
I
F
C
N
T
K
R
K
V
----
D
W
L
T
E
K
M
R
E
A
-----
N
F
--------
T
V
S
S
M
H
G
D
M
P
Q
K
---------------------------------------------
E
R
-----
E
S
I
M
K
E
F
R
-----
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
--
D
V
---
P
Q
V
S
L
I
I
---
N
Y
D
L
P
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
36.97
15%
17
- C2 -
-
5SUQ
3
SUB2_YEAST
A:
[83-411]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
P
S
E
V
Q
Q
H
T
I
P
Q
S
I
H
-------
G
T
D
V
-------
L
C
Q
A
K
S
G
L
G
K
T
A
V
F
V
L
S
T
L
Q
Q
L
D
P
V
P
------------
G
E
V
A
V
V
V
I
C
N
A
R
E
L
A
Y
Q
I
R
N
E
Y
L
R
--
F
--------
S
K
Y
M
P
D
V
K
-
T
-
A
V
F
Y
G
G
T
----------------
P
I
S
K
D
A
E
L
--
L
K
NK-----
D
T
A
P
H
I
V
V
A
T
P
G
R
L
K
A
L
V
R
---
E
K
----
Y
I
D
L
--
S
H
V
K
N
F
V
I
D
E
C
D
K
V
L
E
E
L
D
-
M
R
----
R
D
V
Q
E
I
F
R
A
-----------------------
T
P
R
-
D
K
Q
V
M
M
F
S
A
T
-
L
-
S
Q
E
I
R
-------------------
P
I
C
R
R
F
L
Q
-------------
N
P
L
E
I
F
V
---------------------
G
L
Q
Q
Y
Y
I
K
L
E
------------------------
E
R
----
E
K
N
R
K
L
A
Q
L
L
---
D
D
------
L
E
F
N
--
Q
V
I
I
F
V
K
S
T
T
R
A
----
N
E
L
T
K
L
L
N
A
S
-----
N
F
--------
P
A
I
T
V
H
G
H
M
K
Q
E
---------------------------------------------
E
R
-----
I
A
R
Y
K
A
F
K
-----
D
F
E
K
R
I
C
V
S
T
D
V
F
G
R
G
I
D
I
---
E
R
I
N
L
A
I
---
N
Y
D
L
T
N
------
E
A
D
Q
Y
L
H
R
V
G
R
A
G
R
F
G
T
---
K
G
L
A
-
I
S
F
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
35.71
15%
20
* C2 *
-
4D26
2
?
A:
[71-406]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
-------
G
R
D
L
-------
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
Q
D
P
--
K
-
D
L
I
S
E
N
G
C
A
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
--
F
--------
S
Y
G
S
-
V
L
K
-
V
-
A
V
A
Y
G
G
T
----------------
A
V
R
H
Q
G
D
N
--
I
--------
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
---
R
N
----
R
V
S
F
--
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
-
G
-
F
M
----
P
S
I
E
K
M
M
L
H
-------------------
P
T
M
V
E
T
T
-
K
R
Q
T
L
M
F
S
A
T
-
F
-
P
E
D
I
Q
-------------------
H
L
A
G
R
F
-----------------
L
N
N
Y
L
F
V
-
A
V
G
I
V
-
G
G
A
S
T
D
V
E
------
Q
I
F
I
E
V
T
K
-------------------------
Y
E
K
R
-
N
S
L
K
Q
L
I
E
E
------------
N
D
G
K
--
R
I
L
V
F
V
E
T
K
R
N
A
----
D
F
I
A
A
M
L
S
E
Q
-----
Q
L
--------
L
T
S
S
I
H
G
D
R
M
Q
R
---------------------------------------------
E
R
-----
E
E
A
L
Q
N
F
K
-----
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
---
K
N
V
D
I
V
V
---
N
Y
D
L
P
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
---
R
G
K
A
-
V
S
F
Y
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
35.65
14%
1
- C2 -
-
4U7D
-
RECQ1_HUMAN
C:
[44-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
A
-------
G
K
E
V
-------
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
--
S
--
D
--------------
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
--
L
--------
G
I
S
A
-
T
-
M
-
L
-
N
A
S
S
S
K
E
---------------
H
V
K
W
V
H
A
E
M
VN
K
--------
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
A
K
S
K
M
FMS
R
L
E
-
K
-
A
Y
E
A
--
R
R
F
T
R
I
A
V
D
E
V
H
C
C
S
Q
----
W
G
----
H
D
F
R
P
D
Y
K
A
-----------------
L
G
I
L
K
R
Q
F
P
-
N
A
S
L
I
G
L
T
A
T
-
A
-
T
N
H
V
L
-------------------
T
D
A
Q
K
I
L
C
-----------
I
E
---
K
C
F
T
-
F
-
T
A
-----
S
F
N
--------
R
P
N
L
Y
Y
E
V
R
Q
K
------------------------
P
S
N
T
E
D
F
I
E
D
I
V
K
L
I
---
N
G
R
-----
Y
K
G
Q
--
S
G
I
I
Y
C
F
S
Q
K
D
S
----
E
Q
V
T
V
S
L
Q
N
L
-----
G
I
--------
H
A
G
A
Y
H
A
N
L
E
P
E
---------------------------------------------
D
K
-----
T
T
V
H
R
K
W
S
-----
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
---
P
D
V
R
F
V
I
---
H
H
S
M
S
K
------
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
35.28
17%
42
- C1 -
-
5AWH
2
?
A:
[20-778]
--
H
M
Q
L
V
S
N
G
F
E
V
N
L
P
---
D
Q
V
E
V
I
V
R
D
L
P
D
P
S
K
V
K
E
E
R
T
R
L
M
G
Y
W
F
V
H
W
F
D
G
K
L
F
H
L
R
I
K
A
G
G
P
N
V
-------
D
G
E
H
R
A
I
R
T
A
E
H
P
---------
W
L
L
R
A
R
L
D
D
A
L
E
E
A
L
P
K
Y
A
A
V
K
--
K
R
P
F
T
F
L
A
Q
K
D
E
L
I
D
A
A
A
T
A
A
G
L
--
S
H
R
L
L
N
S
-------
F
K
V
I
P
R
F
A
L
S
P
K
I
Y
E
PVD
G
T
T
R
V
G
V
F
V
------
T
I
G
M
R
Y
D
I
E
A
S
L
R
D
L
L
E
A
----------------------------------------------------------------------------------------------------------
G
I
D
L
R
G
M
Y
V
V
---
R
R
K
-------------------------------------
R
Q
P
G
E
R
G
L
L
G
R
V
R
A
I
S
D
D
M
V
Q
L
F
E
ET
D
-
L
----
A
S
V
N
V
N
D
A
K
L
E
G
S
K
E
N
F
T
R
C
L
S
A
L
L
G
---------------
H
-
N
-
Y
-
K
-
K
L
L
N
A
L
D
D
---
Q
----
E
--
A
G
Y
R
T
G
P
R
F
D
D
A
--
V
--------
R
R
M
G
E
F
L
A
----------------
K
K
P
-
I
R
L
A
--
D
N
I
N
A
Q
V
G
D
R
I
V
F
S
N
E
G
------------------------------------
Q
A
R
N
V
R
L
A
-
P
K
V
E
Y
V
F
D
R
T
G
A
-
K
S
A
E
Y
-------------------
A
W
R
G
L
S
Q
F
G
PFD
R
P
S
F
A
N
R
S
P
R
I
L
V
V
Y
P
-
S
-
S
T
Q
G
K
V
E
N
F
L
S
A
F
R
D
G
M
G
S
N
Y
S
G
F
S
K
G
------------------
F
V
D
L
M
G
L
------
T
K
V
E
F
V
M
C
P
V
---
E
V
S
S
A
D
---------------
R
N
G
A
H
----
T
K
Y
N
S
A
I
E
D
K
L
A
G
A
G
E
V
---
H
A
-
G
I
V
V
L
---------
F
---
E
D
H
A
R
------
L
P
D
D
R
N
P
Y
I
H
T
K
S
L
L
L
T
L
G
V
P
T
Q
Q
V
R
M
P
T
V
L
L
-----
E
P
K
S
L
Q
Y
T
-----
L
Q
N
F
S
I
A
T
Y
A
K
L
N
G
T
P
W
---------
T
V
N
---
H
D
K
A
I
N
------
D
E
L
V
V
G
M
G
L
A
E
L
S
G
S
R
T
E
K
R
Q
R
F
V
G
I
T
T
V
F
A
--
G
D
-----------
G
S
Y
L
L
G
N
V
S
K
---
E
C
E
Y
--
E
G
Y
S
D
A
I
R
E
S
M
T
G
I
L
R
E
L
K
K
R
N
-------------------
N
W
R
P
G
D
T
V
R
V
V
F
H
A
---
H
R
P
L
--
K
R
V
D
V
A
S
I
V
F
E
C
T
R
E
I
G
S
D
---------------
Q
N
I
Q
M
A
F
V
T
V
S
H
D
H
P
F
V
----------------
L
I
D
-
R
S
E
R
G
L
E
A
Y
K
G
-----
S
T
A
R
K
G
V
F
A
----
P
P
R
G
A
I
S
R
V
G
R
L
T
R
L
L
A
V
N
S
P
Q
L
I
K
R
A
N
T
P
L
P
T
P
L
L
V
S
L
H
P
D
------
S
T
F
K
D
V
D
Y
L
A
E
Q
A
L
K
F
T
S
L
S
W
R
S
T
L
P
A
A
T
P
V
T
I
F
---------
Y
S
E
R
I
A
E
L
L
G
---
R
L
K
S
I
P
N
W
S
S
A
N
--------------
L
N
I
K
L
K
W
S
R
W
F
L
------------------------------
43
HHSearch
35.23
14%
-0
- C2 -
-
2V1X
1
RECQ1_HUMAN
A:
[44-366]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
A
-------
G
K
E
V
-------
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
--
S
--
D
--------------
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
--
L
--------
G
I
S
A
-
T
-
M
-
L
-
N
A
S
S
S
K
E
---------------
H
V
K
W
V
H
A
E
M
V
N
K
--------
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
A
K
S
K
M
F
M
S
R
L
E
-
K
-
A
Y
E
A
--
R
R
F
T
R
I
A
V
D
E
V
H
C
C
S
Q
----
W
G
----
H
D
F
R
P
D
Y
K
A
-----------------
L
G
I
L
K
R
Q
F
P
-
N
A
S
L
I
G
L
T
A
T
-
A
-
T
N
H
V
L
-------------------
T
D
A
Q
K
I
L
C
-----------
I
E
---
K
C
F
T
-
F
-
T
A
-----
S
F
N
--------
R
P
N
L
Y
Y
E
V
R
Q
K
------------------------
P
S
N
T
E
D
F
I
E
D
I
V
K
L
I
---
N
G
-----
R
Y
K
G
Q
--
S
G
I
I
Y
C
F
S
Q
K
D
S
----
E
Q
V
T
V
S
L
Q
N
L
-----
G
I
--------
H
A
G
A
Y
H
A
N
L
E
P
E
---------------------------------------------
D
K
-----
T
T
V
H
R
K
W
S
-----
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
---
P
D
V
R
F
V
I
---
H
H
S
M
S
K
------
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
34.28
15%
22
- C2 -
-
4D25
3
?
A:
[71-406]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
-------
G
R
D
L
-------
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
Q
D
P
--
K
-
D
L
I
S
E
N
G
C
A
Q
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
--
F
--------
S
Y
G
S
-
V
L
K
-
V
-
A
V
A
Y
G
G
T
----------------
A
V
R
H
Q
G
D
N
--
I
--------
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
F
V
E
---
R
N
----
R
V
S
F
--
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
M
-
G
-
F
M
----
P
S
I
E
K
M
M
L
H
-------------------
P
T
M
V
E
T
T
-
K
R
Q
T
L
M
F
S
A
T
-
F
-
P
E
D
I
Q
-------------------
H
L
A
G
R
F
-----------------
L
N
N
Y
L
F
V
-
A
V
G
I
V
-
G
G
A
S
T
D
V
E
------
Q
I
F
I
E
V
T
K
-------------------------
Y
E
K
R
-
N
S
L
K
Q
L
I
E
E
------------
N
D
G
K
--
R
I
L
V
F
V
E
T
K
R
N
A
----
D
F
I
A
A
M
L
S
E
Q
-----
Q
L
--------
L
T
S
S
I
H
G
D
R
M
Q
R
---------------------------------------------
E
R
-----
E
E
A
L
Q
N
F
K
-----
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
---
K
N
V
D
I
V
V
---
N
Y
D
L
P
K
------
S
I
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
---
R
G
K
A
-
V
S
F
Y
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------