@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNB0: (2017-11-13 )
MNSWLIIGVLTLYIALLFVCAFFGEKHASRLSTRGRMFLFSLTLGVYCSSWTFYGATGAAVREGVIFLPIYLGPLLFVWFGYDIWRRLGRVRQHHAISSIADFVAARYGKSGVLASLVTILAVIAIIPYLALQLRAIALSTSVIMEQSSHIHTTTNSVLLLTSVLAILAMIFGTRQIANTEQHGGLMLAVAFESFVKLFALLCVALFFIFESPANLSQMTSDVNQTFQEVQLFGVPETFWIQTLLAGLAIICLPRQFHVAVVELRDEKHIRGARKWFAVYLILTILAIIPIASWALHAAPKFLTVPDVAVLALPLSYNQQWLALLAFLGGFSASTGMLLVSSVALSIMLSNDLIMPALWRFKLLSRHDKYLPKVLKFSRRISIVAVMLLGFLFFHFFNDINQLSVFGLLAFSAVAQFAPALIGGLYWRGGSRQGVYAGLIIGFLMWSYTLLFPTILRSLPEAYQETAQSILLFGPFGINALRPESLFGFESFAPLTHGVIWSLGLNIVLYIWISKIYRPSVAEQIQAESFFYYETKPLPSPHTSTDLTYLPHDAARLKVGDLFALAKRITGEQPTTQAFENFCEQNHLTLNPNSIANGMWWRLTEQYLAGIIGAASARTLLTTAMINNGLALGQVANILDQASQWQRFNQNLLMTMIDHMTQGVSVVDKNMCLVAWNNQYLKLFGYPKDLVYVGCPIADLIRYNAERGECGPGSVEEHVRKRLHWMKVGSAHEFERIRKDGRVIQMRGNPIAGGGFVTTFADITAFRANEAVLEARVKDRTQQLADALTEQQLAREQADMANMSKSRFIAAASHDLLQPMHAARLFSTVLEQSISTEEDRQTLQQLDRALYGAESMLSALLDIARLEGGTIQPKRQPYPLHDLLSDLELQFKSIAAQRNISLKVHDVSFWIDTDPQWIRRIIQNFVSNALRYTAKGRVVVGVLRSAQQSGHIRIGVWDTGPGIAEEQRIKLFQEFERCGHLSPWGEQGLGLGLAIVQRMTGLLNYPVHVYSELGKGSCFMIEVPIVEPPKVATPAVQAVPLKTKAYRILCLDNDETILEGMSSLLGRWGYQVFKATEPEQALEIIQKENIQVWLIDQHLNHNQLGVDFITQNRQEDVPVALITADSHPELPQQLKELNIVLLKKPLKPASLRAWLSGLKIASTTD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620-........630.......640.......650.......660.......---670.......680.......690.......700.......710.......720.......--730.......740...--.--...750.-----......760.......770.......780.......790.......800.......810.......820.......830...--.------.-..------840.......850...----....860.......870.......880.......890.......-------900--...---.-----.-------..910.......920.......930..-.-.---.----..940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MN
S
W
L
I
I
G
V
L
T
L
Y
I
A
L
L
F
V
C
A
F
F
G
E
K
H
A
S
R
L
STRG
R
M
F
L
F
S
L
T
L
G
V
Y
CS
S
W
T
FYGAT
G
A
A
VRE
G
V
I
F
L
P
I
Y
L
G
P
L
L
F
V
WF
G
Y
D
I
W
R
R
L
G
R
V
R
Q
H
H
A
I
S
S
I
A
D
F
V
A
A
R
YGKS
G
V
L
A
S
L
V
T
I
L
A
V
I
A
I
I
P
Y
L
A
L
Q
L
R
A
I
A
L
S
T
S
V
I
MEQSS
H
I
HTTT
N
S
V
L
L
L
T
S
V
L
A
I
L
A
M
I
F
GTRQIANTEQHG
G
L
M
L
A
V
A
F
E
S
F
V
K
L
F
A
L
L
C
V
A
L
F
F
I
FESPA
N
L
S
Q
M
T
S
D
V
N
Q
T
F
Q
E
V
Q
LFGV
P
E
T
F
W
I
Q
T
L
L
A
G
L
A
I
I
CLPRQ
F
H
V
A
V
V
E
LRD
E
K
H
I
R
G
A
R
K
W
F
A
V
Y
L
I
L
T
I
L
A
I
I
P
I
A
S
W
A
L
HAAP
K
F
L
TVP
D
V
A
V
L
A
LPLSY
N
Q
Q
W
L
A
L
L
A
F
LGGFSAST
G
M
L
L
V
S
S
V
A
L
S
I
M
LSND
L
I
M
P
A
L
W
R
F
K
L
L
S
R
H
D
K
Y
L
P
K
V
L
K
F
S
R
R
I
S
I
V
A
V
M
L
L
G
F
L
F
F
H
F
F
N
D
I
N
Q
L
S
V
F
G
L
L
A
F
S
A
V
A
Q
F
A
P
A
L
I
G
G
L
Y
WRGGSRQ
G
V
Y
A
G
L
I
I
G
F
L
M
W
S
Y
T
L
L
F
P
T
I
L
R
S
L
P
E
A
Y
Q
E
T
A
Q
S
I
L
L
FGPFGINALRPESLFG
F
E
S
F
A
P
L
T
H
G
V
I
W
S
LG
L
N
I
V
L
Y
I
W
I
S
K
IYR
P
S
V
A
E
Q
IQA
E
S
F
F
Y
Y
ETKPLPSPHTST
D
L
T
YLPHD
A
A
RL
K
V
G
D
L
F
A
L
A
K
R
ITGEQP
T
T
Q
A
F
E
N
F
C
EQN
H
L
T
L
N
P
N
S
IAN
G
M
W
W
R
L
T
E
Q
Y
L
A
G
I
I
GAA
S
A
R
T
L
L
--
T
T
A
M
INNGL
A
L
G
Q
V
A
N
I
L
D
Q
A
S
Q
W
Q
R
F
N
Q
N
L
L
M
T
M
I
D
H
M
TQ
G
V
S
VVDK---
N
M
C
L
V
A
WNN
Q
Y
L
K
L
FGYPK
D
L
V
Y
VGC
P
I
A
D
L
I
R
YNAERGECGPG
S
V
E
E
H
V
R
K
R
L
H
W
MKVG--
S
A
H
E
F
E
R
I
RKDG
R
V
I
Q
--M--RGNPIAG-----GG
F
V
T
T
F
A
D
I
T
A
FRA
N
E
A
V
L
E
A
R
V
K
D
R
T
Q
Q
L
A
D
A
L
T
E
Q
Q
L
A
R
E
Q
A
D
M
A
NMSKS
R
F
I
AAA
S
H
D
L
L
Q
P
M
H
A
A
R
L
F
S
T
V
L
E
QSIS--
T
------
E
-
E
D
------
R
Q
T
L
Q
Q
L
D
R
A
L
Y
G
A
E
S
----
M
L
S
A
L
L
D
I
A
RLEGGTIQPKRQPY
P
L
H
D
L
L
S
D
L
E
L
Q
F
K
S
I
AAQR
N
-------
I
S
L
--
K
V
H
---
D
-----
V
-------
S
F
W
IDT
D
P
Q
W
I
R
R
I
I
Q
N
F
V
S
N
A
L
R
YTA-K-G---
R
----
V
V
V
G
V
L
R
S
AQQSG
H
I
R
I
G
V
WDTGPGI
A
E
E
Q
R
I
K
L
F
Q
E
F
E
R
CGHLSPWGEQGL
G
L
G
L
A
I
V
Q
R
M
T
G
L
LNY
P
V
H
V
Y
S
ELGKG
S
C
F
M
I
EVPIVEPPKVATPA
V
Q
A
VPLKT
K
A
Y
R
I
L
C
LDN
D
E
T
I
L
E
G
M
S
S
L
L
G
R
WG
Y
Q
VFKAT
E
P
E
Q
A
L
E
I
I
Q
KEN
I
Q
V
W
L
IDQHLNHNQL
G
V
D
F
ITQNRQEDV
P
V
A
L
I
TADSHP
E
L
P
Q
Q
L
K
EL
N
I
V
L
LKKPL
K
P
A
S
L
R
A
W
LSGLKIASTTD
36
HHSearch
82.37
21%
-
- C4 -
-
4I5S
-
?
B:
[84-434]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
---
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
-
L
E
C
N
I
L
D
I
L
D
D
D
S
Y
T
-------
Y
N
D
L
I
T
K
-------
T
--
P
E
I
V
L
T
R
R
D
E
Y
D
E
F
I
T
L
R
I
--
R
F
A
L
N
R
R
ESGFI
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
--------------------------------
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
A
L
--
T
------
E
S
V
A
------
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
----
M
I
T
D
L
L
S
L
S
R
I
D
N
Q
T
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
Q
---------
E
I
--
I
R
D
Y
P
-
D
-----
K
-------
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
-
D
G
G
---
K
----
V
T
I
T
M
Q
T
---
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
------
T
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
81.68
18%
-
- C3 -
-
4I5S
-
?
A:
[37-432]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
ED
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
---
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
-
E
C
N
I
L
D
I
L
D
D
D
-------
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
--
R
D
E
Y
D
E
F
I
T
L
R
I
R
F
A
L
--
N
--
R
R
E
S
G
F
I
-----
S
G
L
I
A
V
L
H
D
A
--------------------------------
T
E
Q
E
K
E
E
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
----
A
------
L
-
T
E
------
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
----
M
M
R
M
I
T
D
L
L
S
L
--
S
R
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
Q
S
-------
T
E
I
--
I
R
D
YP-
D
-----
K
-------
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
-
D
-
G
---
G
----
K
V
T
I
T
M
Q
T
T
D
T
--
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
---------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.81
29%
-15
- C4 -
-
3DGE
2
?
A:
[20-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
---------
E
-
L
D
------
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
-------
V
N
V
--
L
F
E
---
S
NVPCP
V
-------
E
A
Y
I
D
--
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
-
K
-
D
APD
K
----
Y
V
K
V
I
L
D
--
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.39
29%
-17
- C4 -
-
4JAV
1
?
A:
[20-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
---------
E
-
L
D
------
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
-------
V
N
V
--
L
F
E
---
S
NVPCP
V
-------
E
A
Y
I
D
--
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
-
K
-
D
AP
D
K
----
Y
V
K
V
I
L
D
--
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
76.22
29%
-26
- C4 -
-
2C2A
1
?
A:
[20-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
---------
E
-
L
D
------
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
-------
V
N
V
--
L
F
E
---
S
NVPCP
V
-------
E
A
Y
I
D
--
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
-
K
-
D
AP
D
K
----
Y
V
K
V
I
L
D
--
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.83
28%
-13
- C4 -
-
4JAS
1
?
A:
[20-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
---------
E
-
L
D
------
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
-------
V
N
V
--
L
F
E
---
S
NVPCP
V
-------
E
A
Y
I
D
--
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
-
K
-
D
AP
D
K
----
Y
V
K
V
I
L
D
--
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
75.52
29%
2
- C4 -
-
4JAV
1
?
A:
[19-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
--
E
LD
L
---
S
-
T
L
------
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
----
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
-------
V
N
V
--
L
F
E
---
S
NVP--
C
-------
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
-
K
-
D
---
A
P
D
K
Y
V
K
V
I
L
D
E
---
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
-------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.22
28%
-29
- C4 -
-
4JAU
1
?
A:
[20-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
---------
E
-
L
D
------
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
-------
V
N
V
--
L
F
E
---
S
NVPCP
V
-------
E
A
Y
I
D
--
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
-
K
-
D
AP
D
K
----
Y
V
K
V
I
L
D
--
E
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
---------
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
---------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
74.79
19%
1
- C4 -
-
4GCZ
2
FIXL_BRADU (first)
A:
[8-373]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
P
G
Q
L
E
V
I
K
K
A
L
D
H
V
R
V
G
V
V
I
T
D
P
ALE
D
N
P
I
V
Y
V
N
Q
G
F
V
Q
M
T
G
Y
E
T
E
E
I
-
L
G
K
N
C
R
F
L
Q
G
K
H
T
D
P
A
------
E
V
D
N
I
R
---
T
A
L
Q
N
K
E
P
V
T
V
Q
I
Q
N
Y
K
K
D
G
T
M
F
W
--
N
E
L
N
I
D
P
M
E
I
ED
K
--
T
Y
F
V
G
I
Q
N
D
I
T
E
H
Q
Q
T
Q
A
R
L
Q
E
L
Q
----
S
E
L
V
-------
H
-----
V
S
R
L
S
A
M
G
E
M
A
S
A
L
A
H
E
L
N
Q
P
L
A
A
I
S
N
Y
M
K
G
S
R
R
L
L
A
--
G
SSDPN
T
P
-
K
V
------
E
S
A
L
D
R
A
A
E
Q
A
L
R
A
G
Q
----
I
I
R
R
L
R
D
F
V
A
R
G
E
S
----
E
K
R
V
E
S
L
S
K
L
I
E
E
A
G
A
L
G
L
A
G
A
R
E
Q
N
-------
V
Q
L
--
R
F
S
LD-
P
-----
G
-------
A
D
L
V
L
A
D
R
V
Q
I
Q
Q
V
L
V
N
L
F
R
N
A
L
E
A
M
A
-
Q
-
S
Q--
R
----
R
E
L
V
V
T
N
T
P
A
A
D
D
M
I
E
V
E
V
S
D
T
G
S
G
F
Q
D
D
V
I
P
N
L
F
Q
T
F
F
T
T
K
------
D
T
G
M
G
V
G
L
S
I
S
R
S
I
I
E
A
H
G
G
R
M
W
A
E
S
N
A
S
G
G
A
T
F
R
F
T
L
P
A
A
D
------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
72.17
29%
10
- C4 -
-
2C2A
1
?
A:
[19-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
--
E
LDL---
S
-
T
L
------
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
----
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
H
N
-------
V
N
V
--
L
F
E
---
S
NVP--
C
-------
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
-
K
-
D
---
A
P
D
K
Y
V
K
V
I
L
D
E
---
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
68.89
19%
17
- C4 -
-
4GCZ
1
FIXL_BRADU (first)
B:
[7-376]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
I
P
G
Q
L
E
V
I
K
K
A
L
D
H
V
R
V
G
V
V
I
T
D
P
ALE
D
N
P
I
V
Y
V
N
Q
G
F
V
Q
M
T
G
Y
E
T
E
E
I
-
L
G
K
N
C
R
F
L
Q
G
K
H
T
D
P
A
------
E
V
D
N
I
R
---
T
A
L
Q
N
K
E
P
V
T
V
Q
I
Q
N
Y
K
K
D
G
T
M
F
W
--
N
E
L
N
I
D
P
M
E
I
ED
K
--
T
Y
F
V
G
I
Q
N
D
I
T
E
H
Q
Q
T
Q
A
R
L
Q
E
L
Q
----
S
E
L
V
-------
H
-----
V
S
R
L
S
A
M
G
E
M
A
S
A
L
A
H
E
L
N
Q
P
L
A
A
I
S
N
Y
M
K
G
S
R
R
L
L
A
--
G
SSDPN
T
P
-
K
V
------
E
S
A
L
D
R
A
A
E
Q
A
L
R
A
G
Q
----
I
I
R
R
L
R
D
F
V
A
-
G
E
S
----
E
K
R
V
E
S
L
S
K
L
I
E
E
A
G
A
L
G
L
A
G
A
R
E
Q
N
-------
V
Q
L
--
R
F
S
LD-
P
-----
G
-------
A
D
L
V
L
A
D
R
V
Q
I
Q
Q
V
L
V
N
L
F
R
N
A
L
E
A
M
A
-
Q
-
S
Q--
R
----
R
E
L
V
V
T
N
T
P
A
A
D
D
M
I
E
V
E
V
S
D
T
G
S
G
F
Q
D
D
V
I
P
N
L
F
Q
T
F
F
T
T
K
------
D
T
G
M
G
V
G
L
S
I
S
R
S
I
I
E
A
H
G
G
R
M
W
A
E
S
N
A
S
G
G
A
T
F
R
F
T
L
P
A
A
D
E
N
L
---------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
67.30
23%
-8
- C4 -
-
4U7O
1
?
A:
[35-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
--
K
DP----
E
-
V
A
------
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
----
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
NPA
K
Y
--
Y
T
I
K
R
E
F
T
---
K
-----
R
-------
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
-
D
-
G
G
--
V
----
V
T
C
R
L
L
E
---
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
66.91
23%
-5
- C4 -
-
5C93
1
?
A:
[13-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
KD
P
------
E
-
V
A
------
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
----
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
NPA
K
Y
Y
T
I
K
R
--
E
F
T
---
K
-----
R
-------
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
-
D
-
G
G
--
V
----
V
T
C
R
L
L
E
---
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
65.82
23%
-9
- C4 -
-
4U7O
1
?
A:
[27-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
K
I
D
N
-
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
--
K
------
D
-
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
----
R
----
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
-------
N
P
A
--
K
Y
Y
---
T
-----
I
K
R
E
F
T
K
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
-
D
-
G
---
G
----
V
V
T
--
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
---------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
64.17
23%
-4
- C4 -
-
5C93
1
?
A:
[5-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
K
I
D
N
-
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
--
K
------
D
-
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
----
R
----
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
-------
N
P
A
--
K
Y
Y
---
T
-----
I
K
R
E
F
T
K
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
-
D
-
G
---
G
----
V
V
T
--
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
---------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.38
23%
-11
- C4 -
-
4ZKI
-
?
A:
[27-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
K
I
D
N
-
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
--
K
------
D
-
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
----
R
----
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
--------
N
P
A
--
K
Y
Y
---
T
-----
I
K
R
E
F
T
KR
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
-
D
-
G
---
G
----
V
V
T
--
C
R
L
L
E
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
---------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
62.59
25%
-
- C4 -
-
4Q20
-
DIVL_CAUCR
A:
[526-758]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
A
D
R
S
A
A
L
A
E
A
---
E
R
L
K
R
D
-----------
F
V
G
N
V
S
Y
E
L
R
T
P
L
T
T
I
I
G
Y
S
E
L
L
E
R
A
D
---
S
------
E
-
R
G
------
R
N
H
V
A
A
V
R
A
A
A
T
Q
L
A
R
----
S
I
D
D
V
L
D
M
A
Q
I
D
A
G
E
M
A
L
E
I
E
D
I
R
V
S
D
L
L
L
N
A
Q
E
R
A
L
K
D
A
Q
L
G
G
-------
V
T
L
--
A
V
E
C
E
E
D
-----
V
-------
G
L
-
I
R
G
D
G
K
R
L
A
Q
T
L
D
H
L
V
E
N
A
L
R
Q
T
P
P
G
-
G
---
R
----
V
T
L
S
A
R
R
A
L
---
G
E
V
R
L
D
V
S
D
T
G
R
G
V
P
F
H
V
Q
A
H
I
F
D
R
F
V
G
R
D
R
G
G
P
------
G
L
G
L
A
L
V
K
A
L
V
E
L
H
G
G
W
V
A
L
E
S
E
P
G
N
G
S
T
F
T
C
H
L
P
E
T
Q
------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
59.95
25%
-11
- C4 -
-
4BIV
2
CPXA_ECOLI
A:
[75-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
------------
E
------
S
K
E
L
E
R
I
E
T
E
A
Q
R
L
D
S
----
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
-
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
M
G
-------
K
S
L
--
T
V
N
F
P
-
P
-----
G
-------
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
---
T
---
K
----
I
E
V
G
F
A
V
---
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
57.86
25%
-19
- C4 -
-
4BIX
-
CPXA_ECOLI
B:
[76-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
M
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
--
E
----------------
S
K
E
L
E
R
I
E
T
E
A
Q
R
L
D
S
----
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
-
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
M
G
-------
K
S
L
--
T
V
N
F
P
-
P
-----
G
-------
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
---
T
---
K
----
I
E
V
G
F
A
V
---
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
K
------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
57.51
28%
-127
- C4 -
-
3SL2
1
A:
[32-153]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
R
-------
D
L
Y
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
-
E
-
G
---
G
----
H
V
T
F
S
I
D
V
N
E
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
E
------------------------------------------------------------------------------------------------------------------------------------------