@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNB4: (2017-11-13 )
MTQLQQPIKFAYWVPNVSGGLVVSNIEQRTDWSYDYNVRLAQAAENNGFEYALTQIRFTAGYGAENQHESVSFSHALLAKTEKLKVIAAILPGPWKPALAAKQLATINYLTQGRIAINVVSGWFRGEFDAIGEEWPEHDERYVRSEEFIRTLKGIWTTDNYSFNGKYYQFQNYTLKPKPLQKPHIEVFQGGSSRAARDMASRVSDWYFTNGNTVEEIQKQVEDIRAKAKANNHQVKIGVNAFIIARDTEEEAKAVLQEIIDKANTEAVNAFGDATREAGAASPEQEGNWAKSTFEDLVQYNDGFKTNLIGTPQQIAERIVALKNVGVDLVLSGFLHFIEEVEYFGEKVLPLVRQLELQGFVAQTF
Atome Classification :
(20 SA)
.........10.....---.-----..20........30........40........50..----.---.....60--..------------.--....-----.70........80........90-.-.-.-.....100.......110.......120.......-130-..-.-.-------.-----------..---140.......150...----..---------------------..----------------------160.......170.......180.......190.......200.......210--.---.....-..220.......230-....---.--....240--........---250.......260....----.-..---270.-------..------------.-...280--------.---------.----..-..----------.290...--....---.-.300-.---------------.------.......310.......320.-.-.-...-.330...---.------...340-.........350.....--..360...----------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTQLQQP
I
K
F
A
Y
W
VPN---V-----SG
G
L
V
V
SNIEQRTDWS
Y
D
YN
V
R
L
A
QAAENNG
F
E
Y
A
L
----
T
---
Q
I
R
F
TAG--YG------------A--ENQH-----ES
V
S
F
S
H
A
L
L
AKTE
K
L
K
V
I
A
A
IL-P-G-P-WK
P
A
L
A
A
K
Q
L
A
T
I
N
Y
LTQG
R
I
A
I
N
V
V
S
G
W
FRG
E
F
D
-
A
I
G
-
E
E-W-P-------
E
-----------
H
D
---
E
R
Y
V
R
S
E
E
F
I
R
T
L
K
G
I----WT---------------------TD----------------------
N
Y
S
FN
G
K
Y
Y
Q
FQ
N
Y
TLKPKPLQKPH
I
E
V
F
QGGS
S
R
A
A
R
D
M
A
S
R
VS
D
W
Y
FTNG---N---
T
V
E
E
I
-
Q
K
Q
V
E
D
I
R
A
K
AKA---NN
H
Q
---
V
--
K
I
G
V
N
A
---
F
I
I
ARD
T
E
---
E
E
A
K
A
V
L
Q
E
I
I
D
KAN
T
E
----
A
-
V
N
---
A
F
G
D
-------
A
T
------------R-EAGAAS--------P---------E----QE-GN----------
W
A
--
K
S
T
--
F
E
D
L
---
V
-
Q
Y---N---------------D------GFKTNLIG
T
P
Q
Q
I
A
E
R
I
V
A
L
K
-N-V-
G
V
D
-
L
V
L
S
G
F
L
---
H
------
F
I
E
E
---
V
E
Y
F
G
E
K
V
L
P
L
V
R
Q
L
E
L
--
Q
G
F
VAQTF----------
41
Fugue
77.30
25%
-100
- C4 -
-
1M41
-
SSUD_ECOLI
A:
[1-361]
------
S
L
N
M
F
W
F
L
P
T
---
H
-----
G
D
G
H
Y
L
G
T
E
E
G
S
R
P
V
D
H
G
Y
L
Q
Q
I
A
Q
A
A
D
R
L
G
Y
T
G
V
L
----
I
---
P
---------
T
------------
G
--
R
S
C
E
-----
D
A
W
L
V
A
A
S
M
I
P
V
T
Q
R
L
K
F
L
V
A
L
R
-
P
-
S
-
V
-
T
S
P
T
V
A
A
R
Q
A
A
T
L
D
R
L
S
N
G
R
A
L
F
N
L
V
T
G
S
D
P
Q
E
L
A
-
G
D
G
-
V
F
---
L
-------
D
-----------
H
S
---
E
R
Y
E
A
S
A
E
F
T
Q
V
W
R
R
L
----
L
Q
---------------------
R
E
----------------------
T
V
D
F
N
G
K
H
I
H
V
R
G
A
K
L
L
F
P
A
I
Q
Q
P
Y
P
P
L
Y
F
G
G
S
S
D
V
A
Q
E
L
A
A
E
Q
V
D
L
Y
L
T
W
G
---
E
---
P
P
E
L
V
-
K
E
K
I
E
Q
V
R
A
K
A
A
A
---
H
G
R
K
---
I
--
R
F
G
I
R
L
---
H
V
I
V
R
E
T
N
---
D
E
A
W
Q
A
A
E
R
L
I
S
H
L
L
E
I
----
S
-
P
N
---
L
W
A
G
-------
V
G
------------
L
-
V
------------------------------------------------------------------
R
---------------
G
------
G
A
G
T
A
L
V
G
D
G
P
T
V
A
A
R
I
N
E
Y
A
-
A
-
L
-
G
I
D
-
S
F
V
L
S
G
Y
---
P
------
H
L
E
E
---
A
Y
R
V
G
E
L
L
F
P
L
L
D
V
A
I
P
--
E
I
P
Q
P
Q
P
L
----------
3
PsiBlast_PDB
75.10
26%
-87
- C4 -
-
1M41
-
SSUD_ECOLI
A:
[6-348]
-----------
W
F
L
P
T
---
H
-----
G
D
G
H
Y
L
G
T
E
E
G
S
R
P
V
D
H
G
Y
L
Q
Q
I
A
Q
A
A
D
R
L
G
Y
--------
T
---
G
V
L
I
P
T
G
--
R
S
------------
C
--
E
D
--------
A
W
L
V
A
A
S
M
I
P
V
T
Q
R
L
K
F
L
V
A
L
R
-
P
-
S
-
V
-
T
S
P
T
V
A
A
R
Q
A
A
T
L
D
R
L
S
N
G
R
A
L
F
N
L
V
T
G
S
D
P
Q
E
L
A
-
G
D
G
-
V
--
F
-
L
-------
D
-----------
H
S
---
E
R
Y
E
A
S
A
E
F
T
Q
V
W
R
R
L
----
L
Q
---------------------
R
E
----------------------
T
V
D
F
N
G
K
H
I
H
V
R
G
A
K
L
L
F
P
A
I
Q
Q
P
Y
P
P
L
Y
F
G
G
S
S
D
V
A
Q
E
L
A
A
E
Q
V
D
L
Y
L
T
W
G
---
E
---
P
P
E
L
V
-
K
E
K
I
E
Q
V
R
A
K
A
A
A
---
H
G
R
K
---
I
--
R
F
G
I
R
L
---
H
V
I
V
R
E
T
N
---
D
E
A
W
Q
A
A
E
R
L
I
S
H
L
-------------------------------------------------------------------------------------------------------------LEISPNLWAGVGLVR
G
------
G
A
G
T
A
L
V
G
D
G
P
T
V
A
A
R
I
N
E
Y
A
-
A
-
L
-
G
I
D
S
F
V
L
S
G
Y
P
---
H
-------
L
E
E
---
A
Y
R
V
G
E
L
L
F
P
L
L
-------------------------
2
PsiBlast_PDB
73.58
26%
-78
- C4 -
-
1NQK
-
SSUD_ECOLI
A:
[7-349]
-----------
W
F
L
P
T
---
H
-----
G
D
G
H
Y
L
G
T
E
E
G
S
R
P
V
D
H
G
Y
L
Q
Q
I
A
Q
A
A
D
R
L
G
Y
--------
T
---
G
V
L
I
P
T
G
--
R
S
------------
C
--
E
D
--------
A
W
L
V
A
A
S
M
I
P
V
T
Q
R
L
K
F
L
V
A
L
R
-
P
-
S
-
V
-
T
S
P
T
V
A
A
R
Q
A
A
T
L
D
R
L
S
N
G
R
A
L
F
N
L
V
T
G
S
D
P
Q
E
L
A
-
G
D
G
-
V
--
F
-
L
-------
D
-----------
H
S
---
E
R
Y
E
A
S
A
E
F
T
Q
V
W
R
R
L
----
L
Q
---------------------
R
E
----------------------
T
V
D
F
N
G
K
H
I
H
V
R
G
A
K
L
L
F
P
A
I
Q
Q
P
Y
P
P
L
Y
F
G
G
S
S
D
V
A
Q
E
L
A
A
E
Q
V
D
L
Y
L
T
W
G
---
E
---
P
P
E
L
V
-
K
E
K
I
E
Q
V
R
A
K
A
A
A
---
H
G
R
K
---
I
--
R
F
G
I
R
L
---
H
V
I
V
R
E
T
N
---
D
E
A
W
Q
A
A
E
R
L
I
S
H
L
D
D
E
----
T
-
I
---------------
A
K
------------
A
-
Q
A
A
F
A
R
---------------------------------------------------------
D
---
N
LEISPNLWAGVGLVR
G
------
G
A
G
T
A
L
V
G
D
G
P
T
V
A
A
R
I
N
E
Y
A
-
A
-
L
-
G
I
D
S
F
V
L
S
G
Y
P
---
H
-------
L
E
E
---
A
Y
R
V
G
E
L
L
F
P
L
L
-------------------------
21
HHSearch
73.27
26%
-71
- C4 -
-
1NQK
-
SSUD_ECOLI
A:
[1-356]
-----
M
S
L
N
M
F
W
F
L
P
T
---
H
-----
G
D
G
H
Y
L
G
T
E
E
G
S
R
P
V
D
H
G
Y
L
Q
Q
I
A
Q
A
A
D
R
L
G
Y
T
G
V
L
----
I
---
P
T
G
R
-----------------------
S
C
E
-----
D
A
W
L
V
A
A
S
M
I
P
V
T
Q
R
L
K
F
L
V
A
L
R
-
P
-
S
-
V
-
T
S
P
T
V
A
A
R
Q
A
A
T
L
D
R
L
S
N
G
R
A
L
F
N
L
V
T
G
S
D
P
Q
E
L
A
-
G
D
G
-
V
F
-
L
---------
D
-----------
H
S
---
E
R
Y
E
A
S
A
E
F
T
Q
V
W
R
R
L
----
L
Q
---------------------
R
E
----------------------
T
V
D
F
N
G
K
H
I
H
V
R
G
A
K
L
L
F
P
A
I
Q
Q
P
Y
P
P
L
Y
F
G
G
S
S
D
V
A
Q
E
L
A
A
E
Q
V
D
L
Y
L
T
W
G
---
E
---
P
P
E
L
V
-
K
E
K
I
E
Q
V
R
A
K
A
A
A
---
H
G
R
K
---
I
--
R
F
G
I
R
L
---
H
V
I
V
R
E
T
N
---
D
E
A
W
Q
A
A
E
R
L
I
S
H
L
D
D
E
----
T
-
I
A
---
K
A
Q
A
-------
A
F
------------
A
R--------------------------------
D
N
----------
L
E
IS
P
N
L
WA
G
V
G
L
---
V
-
R
--------------------
G
------
G
A
G
T
A
L
V
G
D
G
P
T
V
A
A
R
I
N
E
Y
A
-
A
-
L
-
G
I
D
-
S
F
V
L
S
G
Y
---
P
------
H
L
E
E
---
A
Y
R
V
G
E
L
L
F
P
L
L
D
V
A
I
P
--
E
I
----------------
1
PsiBlast_PDB
71.03
36%
0
- C4 -
-
3RAO
-
?
A:
[20-362]
-----
Q
G
V
E
Y
G
F
W
L
P
I
---
F
-----
G
G
W
L
R
N
V
N
D
E
S
M
P
P
-
T
F
E
Y
A
K
Q
T
A
Q
A
A
E
Q
L
G
F
S
T
T
L
----
I
A
E
L
N
L
N
D
I
K
G
--
V
S
------------
A
--
P
S
L
------
E
A
W
T
T
A
A
A
L
A
A
V
T
D
R
L
E
I
M
T
A
V
R
-
P
-
G
-
F
-
H
N
P
A
V
T
A
K
M
A
A
N
I
D
Q
L
S
N
G
R
F
T
L
N
V
V
S
A
W
W
E
E
E
A
K
-
Q
Y
G
-
G
V
-
F
-
T
-------
A
-----------
H
D
---
E
R
Y
D
R
T
E
E
F
V
T
I
L
K
G
L
----
W
K
---------------------
E
E
----------------------
E
F
S
Y
K
G
N
F
Y
E
L
H
H
T
H
L
S
P
K
P
V
Q
K
Q
G
I
K
L
Y
A
G
G
E
S
K
R
G
K
E
V
I
V
N
H
A
D
A
Y
V
M
H
G
---
G
---
T
V
E
E
V
-
S
V
K
I
E
D
M
K
N
R
R
K
K
---
V
T
E
E
---
P
LQ
S
F
G
L
A
A
---
Y
V
I
C
R
H
T
E
---
E
E
A
L
E
E
W
R
R
I
T
D
V
K
--------------------------------------------------------------------------
F
----------
V
S
--
K
S
Q
--
L
E
Q
Q
---
V
-
K
L
---
N
---------------
D
Y
S
V
SNR
G
L
R
P
N
L
I
G
T
P
E
Q
I
A
E
R
I
L
A
F
E
-
K
-
V
-
G
V
T
-
L
L
L
L
Q
F
S
---
P
------
Q
L
E
E
---
M
K
R
F
S
E
K
V
M
P
L
V
-------------------------
22
HHSearch
70.82
35%
9
- C4 -
-
3RAO
-
?
B:
[19-369]
----
F
Q
G
V
E
Y
G
F
W
L
P
I
---
F
-----
G
G
W
L
R
N
V
N
D
E
-
S
M
P
P
T
F
E
Y
A
K
Q
T
A
Q
A
A
E
Q
L
G
F
S
T
T
L
----
I
---
A
E
L
N
L
N
D
--
I
K
------------
G
VS
A
P
S
L
-----
E
A
W
T
T
A
A
A
L
A
A
V
T
D
R
L
E
I
M
T
A
V
R
-
P
-
G
-
F
-
H
N
P
A
V
T
A
K
M
A
A
N
I
D
Q
L
S
N
G
R
F
T
L
N
V
V
S
A
W
W
E
E
E
A
K
-
Q
Y
G
-
G
V
-
F
-
T
-------
A
-----------
H
D
---
E
R
Y
D
R
T
E
E
F
V
T
I
L
K
G
L
----
W
K
---------------------
E
E
----------------------
E
F
S
Y
K
G
N
F
Y
E
L
H
H
T
H
L
S
P
K
P
V
Q
K
Q
G
I
K
L
Y
A
G
G
E
S
K
R
G
K
E
V
I
V
N
H
A
D
A
Y
V
M
H
G
---
G
---
T
V
E
E
V
-
S
V
K
I
E
D
M
K
N
R
R
K
K
---
V
T
E
E
PL-
Q
--
S
F
G
L
A
A
---
Y
V
I
C
R
H
T
E
---
E
E
A
L
E
E
W
R
R
I
T
D
V
K
--
A
L---
G
-
Y
A
---
G
Y
Q
D
-------
F
V
------------
S
-
K
----
S
------------------
Q
----
L
E
-
Q
Q
----------
V
K
--
L
N
D
--
Y
-
S
V
---
S
-
N
--------------------
R
------
G
L
R
P
N
L
I
G
T
P
E
Q
I
A
E
R
I
L
A
F
E
-
K
-
V
-
G
V
T
-
L
L
L
L
Q
F
S
---
P
------
Q
L
E
E
---
M
K
R
F
S
E
K
V
M
P
L
V
E
A
K
R
K
--
E
L
----------------
23
HHSearch
66.21
23%
-4
- C4 -
-
5WAN
5
?
A:
[32-391]
---
E
R
L
M
M
K
I
G
V
F
V
P
I
---
G
-----
N
N
G
W
L
I
S
T
H
A
P
Q
Y
M
P
T
F
E
L
N
K
A
I
V
Q
K
A
E
H
Y
H
F
D
F
A
L
----
S
---
M
I
K
L
R
-
G
--
F
G
G
KTEF-------
W
--
D
H
N
L
-----
E
S
F
T
L
M
A
G
L
A
A
V
T
S
R
I
Q
I
Y
A
T
A
A
-
T
-
L
-
T
-
L
P
P
A
I
V
A
R
M
A
A
T
I
D
S
I
S
G
G
R
F
G
V
N
L
V
T
G
W
Q
K
P
E
Y
E
-
Q
M
G
-
I
W
-
P
-
G
DD-----
Y
-----------
F
S
---
R
R
Y
D
Y
L
T
E
Y
V
Q
V
L
R
D
L
----
W
G
---------------------
T
G
----------------------
K
S
D
F
K
G
D
F
F
T
M
N
D
C
R
V
S
P
Q
P
S
V
--
P
M
K
V
I
C
A
G
Q
S
D
A
G
M
A
F
S
A
R
Y
A
D
F
N
F
C
F
G
---
K
G
VN
T
P
T
A
F
-
A
P
T
A
A
R
M
K
Q
A
A
E
Q
---
T
G
R
D
---
V
--
G
S
Y
V
L
F
---
M
V
I
A
D
E
T
D
---
D
A
A
R
A
K
W
E
H
Y
K
A
G
A
D
E
E
----
A
-
L
S
---
W
L
T
------------------------------------------------------------------------------
D
P
T
-----
S
A
---
V
---------------
N
------
I
N
M
G
T
L
V
G
S
Y
A
S
V
A
R
M
L
D
E
V
A
-
S
V
P
-
G
A
E
-
G
V
L
L
T
F
D
---
D
------
F
L
S
G
---
I
E
T
F
G
E
R
I
Q
P
L
M
Q
C
R
A
H
--
L
P
----------------
4
PsiBlast_PDB
66.09
24%
11
- C4 -
-
5WAN
5
?
A:
[36-385]
-------
M
K
I
G
V
F
V
P
I
---
G
-----
N
N
G
W
L
I
S
T
H
A
P
Q
Y
M
P
T
F
E
L
N
K
A
I
V
Q
K
A
E
H
Y
H
F
D
F
A
L
----
S
---
M
I
K
L
R
-
G
--
F
G
------------
G
--
K
T
E
F
WDHNL
E
S
F
T
L
M
A
G
L
A
A
V
T
S
R
I
Q
I
Y
A
T
A
A
-
T
-
L
-
T
-
L
P
P
A
I
V
A
R
M
A
A
T
I
D
S
I
S
G
G
R
F
G
V
N
L
V
T
G
W
Q
K
P
E
Y
E
-
Q
M
G
--
I
-
W
-
P
-------
G
-----------
D
D
YFS
R
R
Y
D
Y
L
T
E
Y
V
Q
V
L
R
D
L
----
W
G
---------------------
T
G
----------------------
K
S
D
F
K
G
D
F
F
T
M
N
D
C
R
V
S
P
Q
P
--
S
V
P
M
K
V
I
C
A
G
Q
S
D
A
G
M
A
F
S
A
R
Y
A
D
F
N
F
C
F
G
K
G
V
N
---
T
P
T
A
F
-
A
P
T
A
A
R
M
K
Q
A
A
E
Q
---
T
G
R
D
---
V
--
G
S
Y
V
L
F
---
M
V
I
A
D
E
T
D
---
D
A
A
R
A
K
W
E
H
Y
K
A
G
A
D
E
E
----
A
-
L
S
---
W
L
T
------------------------------------------------------------------------
D
P
T
----
S
A
---
V
-
N
I
---
N
---------------
M
------
G
---
T
L
V
G
S
Y
A
S
V
A
R
M
L
D
E
V
A
-
S
-
V
P
G
A
E
-
G
V
L
L
T
F
D
---
D
------
F
L
S
G
---
I
E
T
F
G
E
R
I
Q
P
L
M
Q
------------------------
43
Fugue
60.30
23%
32
- C4 -
-
1TVL
-
MOXC_BACSU
A:
[3-432]
---
R
A
D
F
I
Q
F
G
A
M
I
H
G
---
V
GGT--
T
D
G
W
R
H
P
D
V
D
P
S
A
S
T
N
I
E
F
Y
M
K
K
A
Q
T
A
E
K
G
L
F
S
F
I
F
I
A
D
G
L
---
F
I
S
E
K
S
I
--
P
H
------------
F
--
L
N
R
F
-----
E
P
I
T
I
L
S
A
L
A
S
V
T
K
N
I
G
L
V
G
T
F
S
-
T
-
S
-
F
-
T
E
P
F
T
I
S
R
Q
L
M
S
L
D
H
I
S
G
G
R
A
G
W
N
L
V
T
S
P
Q
E
G
A
A
R
-
N
H
S
K
S
N
-
L
-
P
-------
E
-----------
H
T
---
E
R
Y
E
I
A
Q
E
H
L
D
V
V
R
G
L
----
W
N
SWEHDAFIHNKKTGQFFDQAK
L
H
----------------------
R
L
N
H
K
G
K
Y
F
Q
V
E
G
P
L
N
I
G
R
S
K
Q
G
-
E
P
V
V
F
Q
A
G
S
S
E
T
G
R
Q
F
A
A
K
N
A
D
A
I
F
T
H
S
---
N
---
S
L
E
E
T
-
K
A
F
Y
A
D
V
K
S
R
A
A
D
E
GR
D
P
S
S
---
V
--
R
I
F
P
G
I
---
S
P
I
V
A
D
T
E
---
E
E
A
E
K
K
Y
R
E
F
A
E
L
I
P
I
E
----
N
-
A
V
---
T
E
A
K
-------
A
R
--------------------------------------------------------------
N
L
T
--
L
R
E
V
---
A
-
Q
E
---
M
---------------
A
------
F
P
R
T
L
F
I
G
T
P
E
R
V
A
S
L
I
E
T
W
F
-
N
-
A
-
E
A
A
-
D
G
F
I
V
G
S
---
D
------
I
P
G
T
---
L
D
A
F
V
E
K
V
I
P
I
L
Q
E
R
G
L
YR
Q
D
Y
R
G
G
T
L
R
E
N
L
G
L
G
I
P
Q
40
HHSearch
60.30
24%
34
- C4 -
-
1TVL
-
MOXC_BACSU
A:
[3-413]
---
R
A
D
F
I
Q
F
G
A
M
I
H
G
VGG
T
-----
T
D
G
W
R
H
P
D
V
D
P
S
A
S
T
N
I
E
F
Y
M
K
K
A
Q
T
A
E
K
G
L
F
S
F
I
F
----
I
---
A
D
G
L
F
I
S
--
E
K
SIPH--------
F
--
L
N
R
F
-----
E
P
I
T
I
L
S
A
L
A
S
V
T
K
N
I
G
L
V
G
T
F
S
-
T
-
S
-
F
-
T
E
P
F
T
I
S
R
Q
L
M
S
L
D
H
I
S
G
G
R
A
G
W
N
L
V
T
S
P
Q
E
G
A
A
R
-
N
H
S
-
K
S
N
L
-
P
-------
E
-----------
H
T
---
E
R
Y
E
I
A
Q
E
H
L
D
V
V
R
G
L
----
W
N
---------------------
S
W
EHDAFIHNKKTGQFFDQAKLH-
R
L
N
H
K
G
K
Y
F
Q
V
E
G
P
L
N
I
G
R
S
K
Q
-
G
E
P
V
V
F
Q
A
G
S
S
E
T
G
R
Q
F
A
A
K
N
A
D
A
I
F
T
H
S
---
N
---
S
L
E
E
T
-
K
A
F
Y
A
D
V
K
S
R
A
A
D
---
E
G
R
D
PSS
V
--
R
I
F
P
G
I
---
S
P
I
V
A
D
T
E
---
E
E
A
E
K
K
Y
R
E
F
A
E
L
I
P
I
E
NAVT-----------------------------------------------------------------E
A
K
----------
A
R
--
N
L
T
--
L
R
E
V
---
A
-
Q
E
---
M
---------------
A
------
F
P
R
T
L
F
I
G
T
P
E
R
V
A
S
L
I
E
T
W
F
-
N
A
E
-
A
A
D
-
G
F
I
V
G
S
----
D
------
I
P
G
T
---
L
D
A
F
V
E
K
V
I
P
I
L
Q
E
R
G
L
--
Y
-----------------
37
HHSearch
59.64
22%
15
- C4 -
-
3SDO
2
?
A:
[5-422]
--
M
T
R
K
H
I
H
F
G
V
L
I
Q
G
---
A
GAN--
M
N
A
W
K
H
P
S
V
P
P
D
A
S
V
N
F
D
F
Y
V
D
R
A
R
R
A
E
N
A
G
I
A
F
A
F
----
I
---
A
D
S
A
Y
V
T
--
P
K
SAPH--------
F
--
L
N
R
F
-----
E
P
I
S
L
L
S
A
L
A
V
L
T
S
K
I
G
L
V
G
T
M
S
-
S
-
S
-
Y
-
S
E
P
Y
N
V
A
R
Q
F
A
S
L
D
L
I
S
G
G
R
A
G
W
N
V
V
T
S
S
I
E
G
T
G
K
-
N
Y
G
-
R
P
-
H
-
P
-------
D
-----------
H
A
---
Q
R
Y
A
I
A
A
E
H
L
D
V
V
Q
G
L
----
W
D
---------------------
S
W
DDDALVRDRATGRFFDPDKLH-
R
L
D
H
R
G
R
F
F
S
V
E
G
P
L
N
I
R
R
S
P
Q
-
G
Q
P
V
I
F
Q
A
G
S
S
D
D
G
I
D
L
A
G
R
S
A
D
A
V
F
S
N
G
---
S
---
T
F
D
E
A
-
R
V
F
Y
R
R
V
K
A
A
A
A
A
---
A
G
R
N
PDH
V
--
K
V
F
P
G
I
---
G
P
I
V
G
A
T
Q
---
Q
E
A
D
D
K
Y
R
Q
V
R
D
L
L
S
P
R
E
A
L
A
Y
-
L
S
---
H
F
F
Q
QHDFS--
V
Y
PLDGPFPDIGTL
G
-
S
D
G
F
Q
S
T
T
D
N
I
K
R
L
A
---------
R
----
E
R
-
K
L
----------
T
L
--
R
E
V
--
A
Y
E
V
---
S
-
T
R
R
S
-
N
---------------
I
------
G
T
S
E
A
F
I
G
T
P
E
A
V
A
S
E
M
I
R
W
V
-
D
-
E
G
A
A
D
-
G
F
M
L
G
L
P
---
V
------
T
G
F
G
---
L
D
D
F
V
D
H
V
L
P
V
L
S
A
R
G
Y
--
F
-----------------
34
HHSearch
59.06
23%
31
- C4 -
-
1YW1
2
MOXC_BACSU
A:
[3-416]
---
R
A
D
F
I
Q
F
G
A
M
I
H
G
VG-
G
T----
T
D
G
W
R
H
P
D
V
D
P
S
A
S
T
N
I
E
F
Y
M
K
K
A
Q
T
A
E
K
G
L
F
S
F
I
F
----
I
---
A
D
G
L
F
I
S
--
E
K
SIPH--------
F
--
L
N
R
F
-----
E
P
I
T
I
L
S
A
L
A
S
V
T
K
N
I
G
L
V
G
T
F
S
-
T
-
S
-
F
-
T
E
P
F
T
I
S
R
Q
L
M
S
L
D
H
I
S
G
G
R
A
G
W
N
L
V
T
S
P
Q
E
G
A
A
R
-
N
H
S
-
K
S
N
L
-
P
-------
E
-----------
H
T
---
E
R
Y
E
I
A
Q
E
H
L
D
V
V
R
G
L
----
W
N
---------------------
S
W
EHDAFIHNKKTGQFFDQAKLH-
R
L
N
H
K
G
K
Y
F
Q
V
E
G
P
L
N
I
G
R
S
K
Q
-
G
E
P
V
V
F
Q
A
G
S
S
E
T
G
R
Q
F
A
A
K
N
A
D
A
I
F
T
H
S
---
N
---
S
L
E
E
T
-
K
A
F
Y
A
D
V
K
S
R
A
A
D
---
E
G
R
D
PSS
V
--
R
I
F
P
G
I
---
S
P
I
V
A
D
T
E
---
E
E
A
E
K
K
Y
R
E
F
A
E
L
I
P
I
E
N
A
V
T
Y
-
L
A
------------------------------------------------------------
R
E
A
K
----------
A
R
--
N
L
T
--
L
R
E
V
---
A
-
Q
E
---
M
---------------
A
------
F
P
R
T
L
F
I
G
T
P
E
R
V
A
S
L
I
E
T
W
F
-
N
A
E
-
A
A
D
-
G
F
I
V
G
S
----
D
------
I
P
G
T
---
L
D
A
F
V
E
K
V
I
P
I
L
Q
E
R
G
L
--
Y
R
Q
D
--------------
36
HHSearch
57.57
21%
28
- C4 -
-
5TLC
-
?
A:
[6-428]
------
Q
L
H
L
A
G
F
F
S
A
---
G
NVTHA
H
G
A
W
R
H
V
G
A
T
-
N
G
F
L
T
G
E
F
Y
K
Q
I
A
R
T
L
E
R
G
K
F
D
L
L
F
----
L
---
P
D
G
L
A
I
E
DS--NLETGVGLGGQ-
G
--
A
V
A
L
-----
E
P
T
S
V
I
A
T
M
A
A
V
T
Q
R
L
G
L
G
A
T
V
S
-
T
-
T
-
Y
-
Y
P
P
Y
H
V
A
R
V
F
A
T
L
D
N
L
S
D
G
R
I
S
W
N
V
V
T
S
L
N
D
S
E
A
R
-
N
F
G
-
V
D
-
E
H
L
-------
E
-----------
H
D
---
I
R
Y
D
R
A
D
E
F
L
E
A
V
K
K
L
----
W
S
---------------------
S
W
SEDALLLDKVGGRFADPKKVQ-
Y
V
N
H
R
G
R
W
L
S
V
R
G
P
L
Q
V
P
R
S
R
Q
G
-
E
P
V
I
L
Q
A
G
L
S
P
R
G
R
R
F
A
G
R
W
A
E
A
V
F
S
V
S
---
P
---
N
L
D
I
M
-
R
A
V
Y
Q
D
I
K
A
H
V
A
A
---
A
G
R
D
PEQ
T
--
K
V
F
T
A
V
---
M
P
V
L
G
E
T
E
---
Q
V
A
R
E
R
L
E
Y
L
N
S
L
V
H
P
E
----
V
G
L
S
---
T
L
S
S
H
S
GLNLS
K
Y
PL----------
D
-
T
K
F
S
D
I
--------
V
A
--------
D
L
GDR
H
V
P
T
M
L
Q
M
F
S
A
V
A
G
G
G
A
--
D
L
T
--
L
A
E
L
---
G
-
R
R
Y
G
T
N
---------------
V
------
G
F
V
P
Q
W
A
G
T
A
E
Q
I
A
D
Q
L
I
S
H
F
-
E
-
A
G
A
A
D
-
G
F
I
I
S
P
A
---
Y
------
L
P
G
I
---
Y
E
E
F
V
D
Q
V
V
P
L
L
Q
Q
R
G
V
--------------------
35
HHSearch
55.93
21%
22
- C4 -
-
5TLC
-
?
C:
[6-428]
------
Q
L
H
L
A
G
F
F
S
A
---
G
NVTHA
H
G
A
W
R
H
V
G
A
T
-
N
G
F
L
T
G
E
F
Y
K
Q
I
A
R
T
L
E
R
G
K
F
D
L
L
F
----
L
---
P
D
G
L
A
I
E
DS
Y
G
DNL
E
T
G
V
G
L
GGQ
G
--
A
V
A
L
-----
E
P
T
S
V
I
A
T
M
A
A
V
T
Q
R
L
G
L
G
A
T
V
S
-
T
-
T
-
Y
-
Y
P
P
Y
H
V
A
R
V
F
A
T
L
D
N
L
S
D
G
R
I
S
W
N
V
V
T
S
L
N
D
S
E
A
R
-
N
F
G
-
V
D
-
E
H
L
-------
E
-----------
H
D
---
I
R
Y
D
R
A
D
E
F
L
E
A
V
K
K
L
----
W
S
---------------------
S
W
SEDALLLDKVGGRFADPKKVQ-
Y
V
N
H
R
G
R
W
L
S
V
R
G
P
L
Q
V
P
R
S
R
Q
G
-
E
P
V
I
L
Q
A
G
L
S
P
R
G
R
R
F
A
G
R
W
A
E
A
V
F
S
V
S
---
P
---
N
L
D
I
M
-
R
A
V
Y
Q
D
I
K
A
H
V
A
A
---
A
G
R
D
PEQ
T
--
K
V
F
T
A
V
---
M
P
V
L
G
E
T
E
---
Q
V
A
R
E
R
L
E
Y
L
N
S
L
V
H
P
E
----
V
G
L
S
---
T
L
S
S
H
S
GLNL------------------------------------------------------------------------
E
L
---
G
-
R
R
Y
G
T
N
---------------
V
------
G
F
V
P
Q
W
A
G
T
A
E
Q
I
A
D
Q
L
I
S
H
F
-
E
-
A
G
A
A
D
-
G
F
I
I
S
P
A
---
Y
------
L
P
G
I
---
Y
E
E
F
V
D
Q
V
V
P
L
L
Q
Q
R
G
V
--------------------
27
HHSearch
54.43
20%
12
- C4 -
-
5LXE
1
FGD1_RHOJR
A:
[1-334]
-----
M
V
I
K
F
G
Y
K
A
S
A
---
E
-----
Q
-------------
F
G
P
R
E
L
V
E
L
G
V
L
A
E
A
H
G
M
D
S
A
T
----
V
---
S
D
H
F
Q
P
W
--
R
H
E-----------
G
--
G
H
A
P
-----
F
S
L
A
W
M
T
A
V
G
E
R
T
S
R
L
Q
L
G
T
S
V
M
-
T
P
T
-
F
R
Y
N
P
A
V
V
A
Q
A
F
A
T
M
G
C
L
Y
P
G
R
I
M
L
G
V
G
T
G
E
A
L
N
E
I
A
T
G
F
A
-
G
E
-
W
-
P
-------
E
-----------
F
K
---
E
R
F
A
R
L
R
E
A
V
A
L
M
R
E
L
----
W
L
---------------------
G
D
----------------------
R
V
D
F
E
G
N
Y
Y
K
T
V
G
A
S
I
Y
D
V
P
E
--
G
G
I
P
V
Y
I
A
A
G
G
P
V
V
A
R
Y
A
G
R
S
G
D
G
F
I
C
T
S
G--
K
---
G
M
E
L
Y
T
E
K
L
M
P
A
V
A
E
G
A
E
K
---
A
D
R
D
VAE
I
--
D
K
M
I
E
I
---
K
I
S
Y
D
T
D
P
---
E
L
A
L
E
N
T
R
F
W
A
P
L
S
L
------------------------
P
I
--------------------------------------
E
----
M
E
-
R
A
----------
A
D
--
A
L
P
--
I
E
Q
V
---
A
------------------------------
K
R
W
I
V
A
S
D
P
D
E
A
V
A
Q
I
R
P
Y
L
-
D
-
A
-
G
L
N
-
H
L
V
F
H
A
P
---
G
HD----
Q
K
R
F
---
L
E
L
F
Q
R
D
L
A
P
R
L
R
G
L
----------------------
26
HHSearch
54.17
18%
8
- C4 -
-
1EZW
-
MER_METKA
A:
[2-348]
-----
A
E
V
S
F
G
I
E
L
L
P
---
D
-------------------
D
K
P
T
K
I
A
H
L
I
K
V
A
E
D
N
G
F
E
Y
A
W
----
I
---
C
D
H
Y
N
-----------------------
N
Y
-----
S
Y
M
G
V
L
T
L
A
A
V
I
T
S
K
I
K
L
G
P
G
I
T
-
N
-
P
Y
T
-
R
H
P
L
I
T
A
S
N
I
A
T
L
D
W
I
S
G
G
R
A
I
I
G
M
G
P
G
D
-
K
A
T
F
D
-
K
M
G
-
L
P
-
F
-
P
-------
C
KIPIWNPEAE
D
E
V
---
G
P
A
T
A
I
R
E
V
K
E
V
I
Y
Q
Y
----
L
E
---------------------
G
G
----------------------
P
V
E
Y
E
G
K
Y
V
K
T
G
T
A
D
V
K
A
R
S
I
Q
G
S
D
I
P
F
Y
M
G
A
Q
G
P
I
M
L
K
T
A
G
E
I
A
N
G
V
L
V
N
A
---
S
---
N
P
K
D
F
-
E
V
A
V
P
K
I
E
E
G
A
K
E
---
A
G
R
S
LDE
I
--
D
V
A
A
Y
T
---
C
F
S
I
D
K
D
E
---
D
K
A
I
E
A
T
K
I
V
V
A
F
I
V
M
G
----
S
-------
P
D
V
-------
V
L
------------
E
-
R
H
G
I
D
T
--------
E
K
A
E
Q
I
A
E
A
I
G
----
K
G
-
D
F
G
T
--------
A
I
--
G
L
V
--
D
E
D
M
---
I
------------------------------
E
A
F
S
I
A
G
D
P
D
T
V
V
D
K
I
E
E
L
L
-
K
-
A
-
G
V
T
-
Q
V
V
V
G
S
P
IGP
D
------
K
E
K
A
---
I
E
L
V
G
Q
E
V
I
P
H
F
K
------------------------
38
HHSearch
53.04
21%
47
- C4 -
-
3B9O
1
?
A:
[3-402]
-----
K
K
I
H
I
N
A
F
E
M
N
CVG
H
IA---
H
G
L
W
R
H
P
E
N
Q
R
H
R
Y
T
D
L
N
Y
W
T
E
L
A
Q
L
L
E
K
G
K
F
D
A
L
F
----
L
---
A
D
V
V
G
I
Y
DV
Y
R
QSR
D
T
A
V
R
E
AV-
Q
--
I
P
V
N
-----
D
P
L
M
L
I
S
A
M
A
Y
V
T
K
H
L
A
F
A
V
T
F
S
-
T
-
T
-
Y
-
E
H
P
Y
G
H
A
R
R
M
S
T
L
D
H
L
T
K
G
R
I
A
W
N
V
V
T
S
H
L
P
S
A
D
K
-
N
F
G
-
I
K
-
K
I
L
-------
E
-----------
H
D
---
E
R
Y
D
L
A
D
E
Y
L
E
V
C
Y
K
L
----
W
E
---------------------
G
S
WEDNAVIRDIENNIYTDPSKVH
E
I
N
H
S
G
K
Y
F
E
V
P
G
P
H
L
C
E
P
S
P
Q
-
R
T
P
V
I
Y
Q
A
G
M
S
E
R
G
R
E
F
A
A
K
H
A
E
C
V
F
L
G
G
---
K
---
D
V
E
T
L
-
K
F
F
V
D
D
I
R
K
R
A
K
K
---
Y
G
R
N
PDH
I
--
K
M
F
A
G
I
---
C
V
I
V
G
K
T
H
---
D
E
A
M
E
K
L
N
S
F
Q
K
Y
W
S
L
E
G
---
H
-
L
A
---
H
Y
G
G
--------
G
------------
T
-
G
Y
D
L
S
K
--------
Y
---------
S
----
S
N
-
D
Y
----------
I
G
--
S
I
S
--
V
G
E
I
I
N
N
M
S
K
L
---
D
---------------
G
------
K
W
F
K
L
S
V
G
T
P
K
K
V
A
D
E
M
Q
Y
L
V
E
E
-
A
-
G
I
D
-
G
F
N
L
V
Q
Y
---
V
------
S
P
G
T
---
F
V
D
F
I
E
L
V
V
P
E
L
Q
K
R
G
L
--------------------
18
PsiBlast_PDB
52.83
22%
13
- C4 -
-
1EZW
-
MER_METKA
A:
[21-348]
----------------------------------------------
H
L
I
K
V
A
E
D
N
G
F
E
Y
A
W
----
I
---
C
D
H
Y
-----------------------
N
N
Y
-----
S
Y
M
G
V
L
T
L
A
A
V
I
T
S
K
I
K
L
G
P
G
I
T
N
P
-
Y
-
T
-
R
H
P
L
I
T
A
S
N
I
A
T
L
D
W
I
S
G
G
R
A
I
I
G
M
G
P
G
-
D
K
A
T
F
D
-
K
M
G
-
L
P
-
F
-
P
CKIPIWN
P
-----------
E
A
---
E
D
E
V
G
P
A
T
A
I
R
E
V
K
E
V
I
Y
Q
Y
L
E
---------------------
G
G
----------------------
P
V
E
Y
E
G
K
Y
V
K
T
G
T
A
D
V
K
A
R
S
I
Q
G
S
D
I
P
F
Y
M
G
A
Q
G
P
I
M
L
K
T
A
G
E
I
A
N
G
V
L
V
N
A
---
S
---
N
P
K
D
F
-
E
V
A
V
P
K
I
E
E
G
A
K
E
---
A
G
R
S
---
L
D-
E
I
D
V
A
A
YTC
F
S
I
D
K
D
E
D
K
A
I
E
A
T
K
I
V
V
A
F
I
V
M
G
S
P
D
V
----
V
-
L
E
---
R
H
G
I
-------
D
T
------------
E
-
K
A
E
Q
I
A
------------------
E
----
A
I
-
G
K
----------
G
D
--
F
G
T
--
A
I
G
L
---
V
-
D
E
---
D
---------------
M
------
I
E
A
F
S
I
A
G
D
P
D
T
V
V
D
K
I
E
E
L
L
-
K
-
A
-
G
V
T
-
Q
V
V
V
G
S
P
---
I
------
G
P
D
K
E
K
A
I
E
L
V
G
Q
E
V
I
P
H
F
K
------------------------
39
HHSearch
52.19
21%
49
- C4 -
-
3B9N
-
?
B:
[3-402]
-----
K
K
I
H
I
N
A
F
E
M
N
CVG
H
IA---
H
G
L
W
R
H
P
E
N
Q
R
H
R
Y
T
D
L
N
Y
W
T
E
L
A
Q
L
L
E
K
G
K
F
D
A
L
F
----
L
---
A
D
V
V
G
I
Y
DV
Y
R
QSR
D
T
A
V
R
E
AV-
Q
--
I
P
V
N
-----
D
P
L
M
L
I
S
A
M
A
Y
V
T
K
H
L
A
F
A
V
T
F
S
-
T
-
T
-
Y
-
E
H
P
Y
G
H
A
R
R
M
S
T
L
D
H
L
T
K
G
R
I
A
W
N
V
V
T
S
H
L
P
S
A
D
K
-
N
F
G
-
I
K
-
K
I
L
-------
E
-----------
H
D
---
E
R
Y
D
L
A
D
E
Y
L
E
V
C
Y
K
L
----
W
E
---------------------
G
S
WEDNAVIRDIENNIYTDPSKVH
E
I
N
H
S
G
K
Y
F
E
V
P
G
P
H
L
C
E
P
S
P
Q
-
R
T
P
V
I
Y
Q
A
G
M
S
E
R
G
R
E
F
A
A
K
H
A
E
C
V
F
L
G
G
---
K
---
D
V
E
T
L
-
K
F
F
V
D
D
I
R
K
R
A
K
K
---
Y
G
R
N
PDH
I
--
K
M
F
A
G
I
---
C
V
I
V
G
K
T
H
---
D
E
A
M
E
K
L
N
S
F
Q
K
Y
W
S
L
E
G
---
H
-
L
A
---
H
Y
G
G
--------
G
------------
T
-
G
Y
D
L
S
K
--------
Y
---------
S
----
S
N
-
D
Y
----------
I
G
--
S
I
S
--
V
G
E
I
I
N
N
M
S
K
L
---
D
---------------
G
------
K
W
F
K
L
S
V
G
T
P
K
K
V
A
D
E
M
Q
Y
L
V
E
E
-
A
-
G
I
D
-
G
F
N
L
V
Q
Y
---
V
------
S
P
G
T
---
F
V
D
F
I
E
L
V
V
P
E
L
Q
K
R
G
L
--------------------
24
HHSearch
52.05
16%
-2
- C4 -
-
3FGC
1
LUXA_VIBHA
A:
[1-354]
-------
M
K
F
G
N
F
L
L
T
---
Y
-----
Q
P
P
E
-
L
-----
S
Q
T
E
V
M
K
R
L
V
N
L
G
K
A
S
E
G
C
G
F
D
T
V
W
----
L
---
L
E
H
H
F
T
E
--
F
----------------
G
L
L
G
-----
N
P
Y
V
A
A
A
H
L
L
G
A
T
E
T
L
N
V
G
T
A
A
I
-
V
L
P
-
T
-
A
H
P
V
R
Q
A
E
D
V
N
L
L
D
Q
M
S
K
G
R
F
R
F
G
I
C
R
G
L
Y
D
K
D
F
R
-
V
F
G
-
T
D
-
M
----------------------
D
---
N
S
R
A
L
M
D
C
W
Y
D
L
M
K
E
G
----
F
N
---------------------
E
G
----------------------
Y
I
A
A
D
N
E
H
I
K
F
P
K
I
Q
L
N
P
S
A
Y
T
Q
G
G
A
P
V
Y
V
V
A
E
S
A
S
T
T
E
W
A
A
E
R
G
L
P
M
I
L
S
W
I--
I
---
N
T
H
E
K
-
K
A
Q
L
D
L
Y
N
E
V
A
T
E
---
H
G
Y
D
VTK
I
--
D
H
C
L
S
Y
---
I
T
S
V
D
H
D
S
---
N
R
A
K
D
I
C
R
N
F
L
G
H
W
Y
D
S
----
Y
-
V
N
A
T
K
I
F
D
D
-------
S
D
------------
Q
-
T
K
G
Y
D
F
NK------
G
---------
Q
----
W
R
-
D
F
VLK-----------------
R
R
----
I
-
D
--------------------
Y
------
S
Y
E
I
N
P
V
G
T
P
E
E
C
I
A
I
I
Q
Q
D
I
-
D
A
T
-
G
I
D
-
N
I
C
C
G
F
E
---
A
NGS
E
E
E
I
I
A
S
---
M
K
L
F
Q
S
D
V
M
P
Y
L
K
E
K
----------------------