@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNG0: (2017-11-14 )
MTYGEVMNTIQKIELDTAKLLINGQFLESKTQEWQDIVNPATQEVIGCVPFATVEEVDAAIQAAQDAFASWRQTPIQARMRIMLKLQDLIRANMKEIAQVLTAEQGKTLADAEGDIQRGLEVVEHACSVGTLQMGEYVEGVARGVDTYTLQQPLGVCAGITPFNFPAMIPLWMFPMAIVCGNTFVLKPSEQDPLSTMMLVELAIQAGIPAGVLNVVHGGKEVVDRLCTHKDIKAISFVGSTAVGTHVYNLAGQHGKRVQAMMGAKNHVVVMPDANKEQTLNALVGAAFGAAGQRCMALSVAVMVGDSKQWIQELVEKAKILKVNAGHEPNTDIGPVISKRAKARVIDLINSGVEQGAELLLDGRNVQVQGYESGNFVGATIFSGVNTDMRIYKEEIFGPVLSIICVDTLDEAIALINANPFGNGVGLFTQSGAIARTFQNLIDIGQVGINIPIPVPVPFFSFTGSRGSKLGDLGPYGKQAVQFYTQTKTITSRWFEDSHEVGGVNTTISLR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......-300-.....--.--..310.......320.......330.......340.......350.......360..-.....370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490....-...500.......510
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
Y
G
E
V
M
N
T
I
Q
K
IELD
T
A
K
L
L
I
N
G
Q
F
L
E
S
K
T
Q
E
W
Q
D
IV
N
P
A
T
Q
E
V
IGCVP
F
A
T
V
E
E
V
D
A
A
I
Q
A
A
Q
D
A
F
A
S
W
R
QT
P
I
Q
A
R
M
R
I
M
L
K
L
Q
D
L
I
R
A
N
M
K
E
I
A
Q
V
L
T
A
EQGKTLADAE
G
D
I
Q
R
G
L
E
V
V
E
H
ACSVGT
L
Q
M
G
E
Y
V
E
G
V
A
RGVD
T
Y
TLQQ
P
L
G
VCAGITPFNFPA
M
I
P
L
W
M
F
P
M
A
I
VCG
N
T
F
V
LKPSEQD
P
L
S
T
M
M
L
V
E
L
A
I
QAGI
P
A
G
V
L
N
V
VHG
G
K
E
V
V
D
R
L
CTHKDI
K
A
I
S
F
VGSTAV
G
T
H
V
Y
N
L
AGQH
G
K
R
V
Q
A
M
MGAKN
H
V
V
V
MPDA
N
K
E
Q
T
L
N
A
L
V
G
A
A
FGAAG
Q
R
C
M
A
L
S
-
V
-
A
-
V
M
VG
D
--
S
--
K
Q
W
I
Q
E
L
V
E
KA
K
I
L
K
V
NAGHEPNT
D
I
G
P
V
I
S
K
RA
K
A
R
V
I
D
L
I
N
S
G
V
E
Q
G
A
E
L
L
LDG
R
-
N
V
Q
V
Q
GYESG
N
F
V
G
A
T
I
FSGVNT
D
M
R
I
Y
K
E
E
I
F
G
P
V
L
S
I
I
C
V
D
T
L
D
E
A
I
A
L
INANPFGNGVGLFTQS
G
A
I
A
R
T
F
Q
N
L
I
D
I
G
QVGINIPIPVPVP
F
F
SFTGSRGSKLGDLGP
Y
G
K
Q
A
V
Q
F
Y
TQT
K
T
I
T
S
R
W
FE-DSHEVGGV
N
T
T
I
SLR
144
HHSearch
90.53
46%
-68
- C4 -
-
1T90
1
IOLA_BACSU
D:
[3-479]
--------------
I
R
K
L
K
N
Y
I
N
G
E
W
V
E
S
K
T
D
Q
Y
E
D
V
V
N
P
A
T
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
K
T
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
N
T
K
E
A
L
G
E
V
G
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
M
G
D
S
L
A
S
I
A
T
D
V
E
A
A
N
Y
R
Y
P
I
G
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
T
E
K
L
V
E
L
F
E
K
A
G
L
P
K
G
V
F
N
V
V
Y
G
A
H
D
V
V
N
G
I
L
E
H
P
E
I
K
A
I
S
F
V
G
S
K
P
V
G
E
Y
V
Y
K
K
G
S
E
N
L
K
R
V
Q
S
L
T
G
A
K
N
H
T
I
V
L
N
D
A
N
L
E
D
T
V
T
N
I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
-
V
-
V
-
T
V
E
E
G
--
I
A-
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
D
D
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
A
R
L
V
C
D
G
R
-
E
N
---
V
S
D
D
G
Y
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
N
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
P
M
A
F
F
P
F
S
G
W
K
S
S
F
F
G
T
L
H
A
N
G
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
-------------------
23
PsiBlast_CBE
90.04
48%
-67
- C4 -
-
5TJR
1
?
D:
[38-521]
------------------
K
H
L
I
G
G
E
L
I
-
A
D
T
G
R
T
A
D
V
F
N
P
S
T
----
R
K
V
P
L
A
D
R
E
T
M
Q
Q
A
I
D
A
A
K
A
A
F
P
A
W
R
N
T
P
P
A
K
R
A
Q
V
L
F
R
F
K
Q
L
L
E
A
N
E
E
R
I
V
K
L
I
S
E
E
H
G
K
T
I
E
D
A
A
G
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K
R
G
I
E
N
V
E
Y
A
T
A
A
P
E
I
L
K
G
E
Y
S
R
N
V
G
P
N
I
D
A
W
S
D
F
Q
P
I
G
V
V
A
G
I
T
P
F
N
F
P
A
M
V
P
L
W
M
Y
P
L
A
I
A
C
G
N
T
F
I
L
K
P
S
E
R
D
P
S
S
T
L
L
I
A
E
L
F
H
E
A
G
L
P
K
G
V
L
N
V
V
H
G
D
K
G
A
V
D
A
L
I
E
A
P
E
V
K
A
L
S
F
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G
S
T
P
I
A
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Y
I
Y
S
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G
T
K
R
G
K
R
V
Q
A
L
G
G
A
K
N
H
A
V
L
M
P
D
A
D
L
D
N
A
V
S
A
L
M
G
A
A
Y
G
-----
C
M
A
I
S
-
V
-
A
-
V
C
V
G
D
Q
I
A
--
D
A
L
V
Q
K
L
V
P
Q
I
K
G
L
K
----------------
G
A
A
R
D
K
V
T
G
Y
I
D
T
G
V
A
Q
G
A
E
L
V
V
D
G
R
-
G
Y
K
V
A
G
H
E
N
G
F
F
L
G
G
T
L
F
D
R
V
T
P
E
M
T
I
Y
K
E
E
I
F
G
P
V
L
C
I
V
R
V
N
S
L
E
E
A
M
Q
L
I
N
D
H
E
Y
G
N
G
T
C
I
F
T
R
D
G
E
A
A
R
L
F
C
D
E
I
E
V
G
M
V
G
V
N
V
P
L
P
V
P
V
A
Y
H
S
F
G
G
W
K
R
S
L
F
G
D
L
H
A
Y
G
P
D
G
V
R
F
Y
T
K
R
K
A
I
T
Q
R
W
P
Q
R
K
S
H
E
-----------
5
PsiBlast_PDB
88.70
46%
-54
- C4 -
-
1T90
1
IOLA_BACSU
A:
[2-480]
-------------
E
I
R
K
L
K
N
Y
I
N
G
E
W
V
E
S
K
T
D
Q
Y
E
D
V
V
N
P
A
T
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
K
T
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
N
T
K
E
A
L
G
E
V
G
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
M
G
D
S
L
A
S
I
A
T
D
V
E
A
A
N
Y
R
Y
P
I
G
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
T
E
K
L
V
E
L
F
E
K
A
G
L
P
K
G
V
F
N
V
V
Y
G
A
H
D
V
V
N
G
I
L
E
H
P
E
I
K
A
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G
S
K
P
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G
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Y
V
Y
K
K
G
S
E
N
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K
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S
L
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A
K
N
H
T
I
V
L
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D
A
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D
T
V
T
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I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
V
V
-
T
-
V
E
E
G
I
--
A
--
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
D
D
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
A
R
L
V
C
D
G
R
E
N
V
S
D
D
G
Y
----
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
N
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
P
M
A
F
F
P
F
S
G
W
K
S
S
F
F
G
T
L
H
A
N
G
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
Y
------------------
30
PsiBlast_CBE
88.50
46%
-56
- C4 -
-
1T90
1
IOLA_BACSU
D:
[2-480]
-------------
E
I
R
K
L
K
N
Y
I
N
G
E
W
V
E
S
K
T
D
Q
Y
E
D
V
V
N
P
A
T
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
K
T
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
N
T
K
E
A
L
G
E
V
G
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
M
G
D
S
L
A
S
I
A
T
D
V
E
A
A
N
Y
R
Y
P
I
G
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
T
E
K
L
V
E
L
F
E
K
A
G
L
P
K
G
V
F
N
V
V
Y
G
A
H
D
V
V
N
G
I
L
E
H
P
E
I
K
A
I
S
F
V
G
S
K
P
V
G
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Y
V
Y
K
K
G
S
E
N
L
K
R
V
Q
S
L
T
G
A
K
N
H
T
I
V
L
N
D
A
N
L
E
D
T
V
T
N
I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
V
V
-
T
-
V
E
E
G
I
--
A
--
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
D
D
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
A
R
L
V
C
D
G
R
E
N
V
S
D
D
G
Y
----
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
N
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
P
M
A
F
F
P
F
S
G
W
K
S
S
F
F
G
T
L
H
A
N
G
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
Y
------------------
25
PsiBlast_CBE
88.50
48%
-52
- C4 -
-
4ZZ7
1
?
L:
[4-484]
--------------
M
T
T
I
G
H
L
I
N
G
Q
L
V
T
E
N
T
R
S
-
Q
N
V
F
N
P
A
T
G
E
I
G
K
Q
L
D
L
A
S
T
K
T
V
E
Q
A
I
S
A
A
Q
H
A
F
P
T
W
R
N
T
P
P
L
K
R
A
R
V
M
F
R
F
K
E
L
L
E
Q
H
A
D
E
I
C
R
L
I
G
E
E
H
G
K
I
A
H
D
A
M
G
E
L
Q
R
G
I
E
N
V
E
Y
A
C
G
A
P
E
L
L
K
G
E
H
S
R
N
V
G
P
G
I
D
S
W
S
E
F
Q
P
M
G
V
V
A
G
I
T
P
F
N
F
P
V
M
V
P
L
W
M
F
P
M
A
I
V
C
G
N
C
F
V
L
K
P
S
E
R
D
P
S
S
T
L
Y
I
A
Q
L
L
Q
E
A
G
L
P
D
G
V
M
N
V
V
N
G
D
K
E
A
V
D
A
L
L
H
D
D
R
V
K
A
V
S
F
V
G
S
T
P
I
A
E
Y
I
Y
R
T
A
S
A
N
G
K
R
C
Q
A
L
G
G
A
K
N
H
A
I
V
M
P
D
A
D
M
D
N
A
V
N
Q
L
L
G
A
A
F
G
S
S
G
E
R
C
M
A
L
S
-
V
-
A
-
V
A
V
G
D
--
A
AG
D
A
L
V
S
K
M
T
Q
A
M
Q
K
L
K
V
G
P
S
T
D
S
G
N
D
F
G
P
V
I
T
R
Q
H
Q
E
K
V
I
G
Y
I
N
S
A
E
Q
Q
G
A
T
I
V
V
D
G
R
-
Q
P
K
V
P
N
H
E
N
G
F
F
V
G
G
T
L
I
D
H
V
T
P
E
M
T
S
Y
Q
E
E
I
F
G
P
V
L
Q
V
V
R
V
A
T
M
Q
D
A
M
D
L
I
D
A
H
E
Y
G
N
G
T
C
I
F
T
R
D
G
E
A
A
R
Y
F
S
D
N
I
Q
V
G
M
V
G
I
N
I
P
L
P
V
P
V
A
Y
H
S
F
G
G
W
K
R
S
L
F
G
D
L
H
A
Y
G
P
D
A
V
R
F
Y
T
K
R
K
T
V
T
Q
R
W
------------------
4
PsiBlast_PDB
87.87
47%
-55
- C4 -
-
4IYM
1
?
A:
[30-505]
--------------------
F
I
D
G
K
R
V
A
G
T
S
G
R
V
S
N
I
F
N
P
A
T
G
E
V
Q
G
T
V
A
L
A
S
D
A
D
L
A
A
A
V
E
S
A
K
A
A
Q
P
K
W
A
A
T
N
P
Q
R
R
A
R
V
F
M
K
F
V
Q
L
L
N
D
N
M
N
E
L
A
E
M
L
S
R
E
H
G
K
T
I
D
D
A
K
G
D
I
V
R
G
L
E
V
C
E
F
V
I
G
I
P
H
L
Q
K
S
E
F
T
E
G
A
G
P
G
I
D
M
Y
S
I
R
Q
P
V
G
I
G
A
G
I
T
P
F
N
F
P
G
M
I
P
M
W
M
F
A
P
A
I
A
C
G
N
A
F
I
L
K
P
S
E
R
D
P
S
V
P
I
R
L
A
E
L
M
I
E
A
G
L
P
A
G
I
L
N
V
V
N
G
D
K
G
A
V
D
A
I
L
T
H
P
D
I
A
A
V
S
F
V
G
S
T
P
I
A
R
Y
V
Y
G
T
A
A
M
N
G
K
R
A
Q
C
F
G
G
A
K
N
H
M
I
I
M
P
D
A
D
L
D
Q
A
A
N
A
L
I
G
A
G
Y
G
S
A
G
E
R
C
M
A
I
S
-
V
-
A
-
V
P
V
G
E
E
T
A
--
N
R
L
I
D
K
L
V
P
M
V
E
S
L
R
I
G
P
Y
T
D
E
K
A
D
M
G
P
V
V
T
K
E
A
E
Q
R
I
R
S
L
I
D
S
G
I
E
Q
G
A
K
L
V
V
D
G
R
-
D
F
K
L
Q
G
Y
E
N
G
H
F
I
G
G
C
L
F
D
D
V
T
P
D
M
D
I
Y
K
T
E
I
F
G
P
V
L
S
V
V
R
A
R
N
Y
E
E
A
L
S
L
P
M
K
H
E
Y
G
N
G
V
A
I
Y
T
R
D
G
D
A
A
R
D
F
A
S
R
I
N
I
G
M
V
G
V
N
V
P
I
P
V
P
L
A
Y
H
S
F
G
G
W
K
S
S
S
F
G
D
L
N
Q
H
G
T
D
S
I
K
F
W
T
R
T
K
T
I
T
S
R
W
------------------
24
PsiBlast_CBE
87.83
48%
-67
- C4 -
-
5TJR
1
?
B:
[38-521]
------------------
K
H
L
I
G
G
E
L
I
-
A
D
T
G
R
T
A
D
V
F
N
P
S
T
G
E
A
V
R
K
V
P
L
A
D
R
E
T
M
Q
Q
A
I
D
A
A
K
A
A
F
P
A
W
R
N
T
P
P
A
K
R
A
Q
V
L
F
R
F
K
Q
L
L
E
A
N
E
E
R
I
V
K
L
I
S
E
E
H
G
K
T
I
E
D
A
A
G
E
L
K
R
G
I
E
N
V
E
Y
A
T
A
A
P
E
I
L
K
G
E
Y
S
R
N
V
G
P
N
I
D
A
W
S
D
F
Q
P
I
G
V
V
A
G
I
T
P
F
N
F
P
A
M
V
P
L
W
M
Y
P
L
A
I
A
C
G
N
T
F
I
L
K
P
S
E
R
D
P
S
S
T
L
L
I
A
E
L
F
H
E
A
G
L
P
K
G
V
L
N
V
V
H
G
D
K
G
A
V
D
A
L
I
E
A
P
E
V
K
A
L
S
F
V
G
S
T
P
I
A
E
Y
I
Y
S
E
G
T
K
R
G
K
R
V
Q
A
L
G
G
A
K
N
H
A
V
L
M
P
D
A
D
L
D
N
A
V
S
A
L
M
G
A
A
Y
G
-----
C
M
A
I
S
-
V
-
A
-
V
C
V
G
D
Q
I
A
--
D
A
L
V
Q
K
L
V
P
Q
I
K
G
L
-----------------
G
A
A
R
D
K
V
T
G
Y
I
D
T
G
V
A
Q
G
A
E
L
V
V
D
G
R
-
G
Y
K
-------
F
F
L
G
G
T
L
F
D
R
V
T
P
E
M
T
I
Y
K
E
E
I
F
G
P
V
L
C
I
V
R
V
N
S
L
E
E
A
M
Q
L
I
N
D
H
E
Y
G
N
G
T
C
I
F
T
R
D
G
E
A
A
R
L
F
C
D
E
I
E
V
G
M
V
G
V
N
V
P
L
P
V
P
V
A
Y
H
S
F
G
G
W
K
R
S
L
F
G
D
L
H
A
Y
G
P
D
G
V
R
F
Y
T
K
R
K
A
I
T
Q
R
W
P
Q
R
K
S
H
E
-----------
140
HHSearch
87.82
46%
-55
- C4 -
-
4IYM
1
?
E:
[23-512]
-------------
M
M
Y
E
L
G
H
F
I
D
G
K
R
V
A
G
T
S
G
R
V
S
N
I
F
N
P
A
T
G
E
V
Q
G
T
V
A
L
A
S
D
A
D
L
A
A
A
V
E
S
A
K
A
A
Q
P
K
W
A
A
T
N
P
Q
R
R
A
R
V
F
M
K
F
V
Q
L
L
N
D
N
M
N
E
L
A
E
M
L
S
R
E
H
G
K
T
I
D
D
A
K
G
D
I
V
R
G
L
E
V
C
E
F
V
I
G
I
P
H
L
Q
K
S
E
F
T
E
G
A
G
P
G
I
D
M
Y
S
I
R
Q
P
V
G
I
G
A
G
I
T
P
F
N
F
P
G
M
I
P
M
W
M
F
A
P
A
I
A
C
G
N
A
F
I
L
K
P
S
E
R
D
P
S
V
P
I
R
L
A
E
L
M
I
E
A
G
L
P
A
G
I
L
N
V
V
N
G
D
K
G
A
V
D
A
I
L
T
H
P
D
I
A
A
V
S
F
V
G
S
T
P
I
A
R
Y
V
Y
G
T
A
A
M
N
G
K
R
A
Q
C
F
G
G
A
K
N
H
M
I
I
M
P
D
A
D
L
D
Q
A
A
N
A
L
I
G
A
G
Y
G
S
A
G
E
R
C
M
A
I
S
-
V
A
V
-
P
V
G
E
E
--
T
A-
N
R
L
I
D
K
L
V
P
M
V
E
S
L
R
I
G
P
Y
T
D
E
K
A
D
M
G
P
V
V
T
K
E
A
E
Q
R
I
R
S
L
I
D
S
G
I
E
Q
G
A
K
L
V
V
D
G
R
-
D
F
K
L
Q
G
Y
E
N
G
H
F
I
G
G
C
L
F
D
D
V
T
P
D
M
D
I
Y
K
T
E
I
F
G
P
V
L
S
V
V
R
A
R
N
Y
E
E
A
L
S
L
P
M
K
H
E
Y
G
N
G
V
A
I
Y
T
R
D
G
D
A
A
R
D
F
A
S
R
I
N
I
G
M
V
G
V
N
V
P
I
P
V
P
L
A
Y
H
S
F
G
G
W
K
S
S
S
F
G
D
L
N
Q
H
G
T
D
S
I
K
F
W
T
R
T
K
T
I
T
S
R
W
P
S
---
G
I
K
D
G
--------
2
PsiBlast_PDB
87.77
48%
-52
- C4 -
-
4ZZ7
1
?
A:
[4-484]
--------------
M
T
T
I
G
H
L
I
N
G
Q
L
V
T
E
N
T
R
S
-
Q
N
V
F
N
P
A
T
G
E
I
G
K
Q
L
D
L
A
S
T
K
T
V
E
Q
A
I
S
A
A
Q
H
A
F
P
T
W
R
N
T
P
P
L
K
R
A
R
V
M
F
R
F
K
E
L
L
E
Q
H
A
D
E
I
C
R
L
I
G
E
E
H
G
K
I
A
H
D
A
M
G
E
L
Q
R
G
I
E
N
V
E
Y
A
C
G
A
P
E
L
L
K
G
E
H
S
R
N
V
G
P
G
I
D
S
W
S
E
F
Q
P
M
G
V
V
A
G
I
T
P
F
N
F
P
V
M
V
P
L
W
M
F
P
M
A
I
V
C
G
N
C
F
V
L
K
P
S
E
R
D
P
S
S
T
L
Y
I
A
Q
L
L
Q
E
A
G
L
P
D
G
V
M
N
V
V
N
G
D
K
E
A
V
D
A
L
L
H
D
D
R
V
K
A
V
S
F
V
G
S
T
P
I
A
E
Y
I
Y
R
T
A
S
A
N
G
K
R
C
Q
A
L
G
G
A
K
N
H
A
I
V
M
P
D
A
D
M
D
N
A
V
N
Q
L
L
G
A
A
F
G
S
S
G
E
R
C
M
A
L
S
-
V
-
A
-
V
A
V
G
D
--
A
A
G
D
A
L
V
S
K
M
T
Q
A
M
Q
K
L
K
V
G
P
S
T
D
S
G
N
D
F
G
P
V
I
T
R
Q
H
Q
E
K
V
I
G
Y
I
N
S
A
E
Q
Q
G
A
T
I
V
V
D
G
R
-
Q
P
K
V
P
N
H
E
N
G
F
F
V
G
G
T
L
I
D
H
V
T
P
E
M
T
S
Y
Q
E
E
I
F
G
P
V
L
Q
V
V
R
V
A
T
M
Q
D
A
M
D
L
I
D
A
H
E
Y
G
N
G
T
C
I
F
T
R
D
G
E
A
A
R
Y
F
S
D
N
I
Q
V
G
M
V
G
I
N
I
P
L
P
V
P
V
A
Y
H
S
F
G
G
W
K
R
S
L
F
G
D
L
H
A
Y
G
P
D
A
V
R
F
Y
T
K
R
K
T
V
T
Q
R
W
------------------
141
HHSearch
87.72
46%
-55
- C4 -
-
4IYM
1
?
C:
[23-511]
-------------
M
M
Y
E
L
G
H
F
I
D
G
K
R
V
A
G
T
S
G
R
V
S
N
I
F
N
P
A
T
G
E
V
Q
G
T
V
A
L
A
S
D
A
D
L
A
A
A
V
E
S
A
K
A
A
Q
P
K
W
A
A
T
N
P
Q
R
R
A
R
V
F
M
K
F
V
Q
L
L
N
D
N
M
N
E
L
A
E
M
L
S
R
E
H
G
K
T
I
D
D
A
K
G
D
I
V
R
G
L
E
V
C
E
F
V
I
G
I
P
H
L
Q
K
S
E
F
T
E
G
A
G
P
G
I
D
M
Y
S
I
R
Q
P
V
G
I
G
A
G
I
T
P
F
N
F
P
G
M
I
P
M
W
M
F
A
P
A
I
A
C
G
N
A
F
I
L
K
P
S
E
R
D
P
S
V
P
I
R
L
A
E
L
M
I
E
A
G
L
P
A
G
I
L
N
V
V
N
G
D
K
G
A
V
D
A
I
L
T
H
P
D
I
A
A
V
S
F
V
G
S
T
P
I
A
R
Y
V
Y
G
T
A
A
M
N
G
K
R
A
Q
C
F
G
G
A
K
N
H
M
I
I
M
P
D
A
D
L
D
Q
A
A
N
A
L
I
G
A
G
Y
G
S
A
G
E
R
C
M
A
I
S
-
V
A
V
-
P
V
G
E
E
--
T
A
-
N
R
L
I
D
K
L
V
P
M
V
E
S
L
R
I
G
P
Y
T
D
E
K
A
D
M
G
P
V
V
T
K
E
A
E
Q
R
I
R
S
L
I
D
S
G
I
E
Q
G
A
K
L
V
V
D
G
R
-
D
F
K
L
Q
G
Y
E
N
G
H
F
I
G
G
C
L
F
D
D
V
T
P
D
M
D
I
Y
K
T
E
I
F
G
P
V
L
S
V
V
R
A
R
N
Y
E
E
A
L
S
L
P
M
K
H
E
Y
G
N
G
V
A
I
Y
T
R
D
G
D
A
A
R
D
F
A
S
R
I
N
I
G
M
V
G
V
N
V
P
I
P
V
P
L
A
Y
H
S
F
G
G
W
K
S
S
S
F
G
D
L
N
Q
H
G
T
D
S
I
K
F
W
T
R
T
K
T
I
T
S
R
W
P
S
---
G
I
K
D
---------
29
PsiBlast_CBE
87.69
48%
-53
- C4 -
-
4ZZ7
1
?
C:
[4-484]
--------------
M
T
T
I
G
H
L
I
N
G
Q
L
V
T
E
N
T
R
S
-
Q
N
V
F
N
P
A
T
G
E
I
G
K
Q
L
D
L
A
S
T
K
T
V
E
Q
A
I
S
A
A
Q
H
A
F
P
T
W
R
N
T
P
P
L
K
R
A
R
V
M
F
R
F
K
E
L
L
E
Q
H
A
D
E
I
C
R
L
I
G
E
E
H
G
K
I
A
H
D
A
M
G
E
L
Q
R
G
I
E
N
V
E
Y
A
C
G
A
P
E
L
L
K
G
E
H
S
R
N
V
G
P
G
I
D
S
W
S
E
F
Q
P
M
G
V
V
A
G
I
T
P
F
N
F
P
V
M
V
P
L
W
M
F
P
M
A
I
V
C
G
N
C
F
V
L
K
P
S
E
R
D
P
S
S
T
L
Y
I
A
Q
L
L
Q
E
A
G
L
P
D
G
V
M
N
V
V
N
G
D
K
E
A
V
D
A
L
L
H
D
D
R
V
K
A
V
S
F
V
G
S
T
P
I
A
E
Y
I
Y
R
T
A
S
A
N
G
K
R
C
Q
A
L
G
G
A
K
N
H
A
I
V
M
P
D
A
D
M
D
N
A
V
N
Q
L
L
G
A
A
F
G
S
S
G
E
R
C
M
A
L
S
-
V
-
A
-
V
A
V
G
D
--
A
AG
D
A
L
V
S
K
M
T
Q
A
M
Q
K
L
K
V
G
P
S
T
D
S
G
N
D
F
G
P
V
I
T
R
Q
H
Q
E
K
V
I
G
Y
I
N
S
A
E
Q
Q
G
A
T
I
V
V
D
G
R
-
Q
P
K
V
P
N
H
E
N
G
F
F
V
G
G
T
L
I
D
H
V
T
P
E
M
T
S
Y
Q
E
E
I
F
G
P
V
L
Q
V
V
R
V
A
T
M
Q
D
A
M
D
L
I
D
A
H
E
Y
G
N
G
T
C
I
F
T
R
D
G
E
A
A
R
Y
F
S
D
N
I
Q
V
G
M
V
G
I
N
I
P
L
P
V
P
V
A
Y
H
S
F
G
G
W
K
R
S
L
F
G
D
L
H
A
Y
G
P
D
A
V
R
F
Y
T
K
R
K
T
V
T
Q
R
W
------------------
28
PsiBlast_CBE
87.65
48%
-51
- C4 -
-
4ZZ7
1
?
D:
[4-484]
--------------
M
T
T
I
G
H
L
I
N
G
Q
L
V
T
E
N
T
R
S
-
Q
N
V
F
N
P
A
T
G
E
I
G
K
Q
L
D
L
A
S
T
K
T
V
E
Q
A
I
S
A
A
Q
H
A
F
P
T
W
R
N
T
P
P
L
K
R
A
R
V
M
F
R
F
K
E
L
L
E
Q
H
A
D
E
I
C
R
L
I
G
E
E
H
G
K
I
A
H
D
A
M
G
E
L
Q
R
G
I
E
N
V
E
Y
A
C
G
A
P
E
L
L
K
G
E
H
S
R
N
V
G
P
G
I
D
S
W
S
E
F
Q
P
M
G
V
V
A
G
I
T
P
F
N
F
P
V
M
V
P
L
W
M
F
P
M
A
I
V
C
G
N
C
F
V
L
K
P
S
E
R
D
P
S
S
T
L
Y
I
A
Q
L
L
Q
E
A
G
L
P
D
G
V
M
N
V
V
N
G
D
K
E
A
V
D
A
L
L
H
D
D
R
V
K
A
V
S
F
V
G
S
T
P
I
A
E
Y
I
Y
R
T
A
S
A
N
G
K
R
C
Q
A
L
G
G
A
K
N
H
A
I
V
M
P
D
A
D
M
D
N
A
V
N
Q
L
L
G
A
A
F
G
S
S
G
E
R
C
M
A
L
S
-
V
-
A
-
V
A
V
G
D
--
A
AG
D
A
L
V
S
K
M
T
Q
A
M
Q
K
L
K
V
G
P
S
T
D
S
G
N
D
F
G
P
V
I
T
R
Q
H
Q
E
K
V
I
G
Y
I
N
S
A
E
Q
Q
G
A
T
I
V
V
D
G
R
-
Q
P
K
V
P
N
H
E
N
G
F
F
V
G
G
T
L
I
D
H
V
T
P
E
M
T
S
Y
Q
E
E
I
F
G
P
V
L
Q
V
V
R
V
A
T
M
Q
D
A
M
D
L
I
D
A
H
E
Y
G
N
G
T
C
I
F
T
R
D
G
E
A
A
R
Y
F
S
D
N
I
Q
V
G
M
V
G
I
N
I
P
L
P
V
P
V
A
Y
H
S
F
G
G
W
K
R
S
L
F
G
D
L
H
A
Y
G
P
D
A
V
R
F
Y
T
K
R
K
T
V
T
Q
R
W
------------------
32
PsiBlast_CBE
87.38
46%
-54
- C4 -
-
1T90
1
IOLA_BACSU
B:
[2-480]
-------------
E
I
R
K
L
K
N
Y
I
N
G
E
W
V
E
S
K
T
D
Q
Y
E
D
V
V
N
P
A
T
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
K
T
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
N
T
K
E
A
L
G
E
V
G
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
M
G
D
S
L
A
S
I
A
T
D
V
E
A
A
N
Y
R
Y
P
I
G
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
T
E
K
L
V
E
L
F
E
K
A
G
L
P
K
G
V
F
N
V
V
Y
G
A
H
D
V
V
N
G
I
L
E
H
P
E
I
K
A
I
S
F
V
G
S
K
P
V
G
E
Y
V
Y
K
K
G
S
E
N
L
K
R
V
Q
S
L
T
G
A
K
N
H
T
I
V
L
N
D
A
N
L
E
D
T
V
T
N
I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
V
V
-
T
-
V
E
E
G
I
--
A
--
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
D
D
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
A
R
L
V
C
D
G
R
E
N
V
S
D
D
G
Y
----
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
N
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
P
M
A
F
F
P
F
S
G
W
K
S
S
F
F
G
T
L
H
A
N
G
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
Y
------------------
27
PsiBlast_CBE
87.29
48%
-51
- C4 -
-
4ZZ7
1
?
E:
[4-484]
--------------
M
T
T
I
G
H
L
I
N
G
Q
L
V
T
E
N
T
R
S
-
Q
N
V
F
N
P
A
T
G
E
I
G
K
Q
L
D
L
A
S
T
K
T
V
E
Q
A
I
S
A
A
Q
H
A
F
P
T
W
R
N
T
P
P
L
K
R
A
R
V
M
F
R
F
K
E
L
L
E
Q
H
A
D
E
I
C
R
L
I
G
E
E
H
G
K
I
A
H
D
A
M
G
E
L
Q
R
G
I
E
N
V
E
Y
A
C
G
A
P
E
L
L
K
G
E
H
S
R
N
V
G
P
G
I
D
S
W
S
E
F
Q
P
M
G
V
V
A
G
I
T
P
F
N
F
P
V
M
V
P
L
W
M
F
P
M
A
I
V
C
G
N
C
F
V
L
K
P
S
E
R
D
P
S
S
T
L
Y
I
A
Q
L
L
Q
E
A
G
L
P
D
G
V
M
N
V
V
N
G
D
K
E
A
V
D
A
L
L
H
D
D
R
V
K
A
V
S
F
V
G
S
T
P
I
A
E
Y
I
Y
R
T
A
S
A
N
G
K
R
C
Q
A
L
G
G
A
K
N
H
A
I
V
M
P
D
A
D
M
D
N
A
V
N
Q
L
L
G
A
A
F
G
S
S
G
E
R
C
M
A
L
S
-
V
-
A
-
V
A
V
G
D
--
A
AG
D
A
L
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K
M
T
Q
A
M
Q
K
L
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V
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P
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T
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N
D
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Q
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V
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Y
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A
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A
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V
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R
-
Q
P
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V
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N
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F
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G
G
T
L
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M
T
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Y
Q
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G
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V
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Q
V
V
R
V
A
T
M
Q
D
A
M
D
L
I
D
A
H
E
Y
G
N
G
T
C
I
F
T
R
D
G
E
A
A
R
Y
F
S
D
N
I
Q
V
G
M
V
G
I
N
I
P
L
P
V
P
V
A
Y
H
S
F
G
G
W
K
R
S
L
F
G
D
L
H
A
Y
G
P
D
A
V
R
F
Y
T
K
R
K
T
V
T
Q
R
W
------------------
143
HHSearch
87.26
47%
-51
- C4 -
-
4ZZ7
1
?
A:
[5-492]
---------------
T
T
I
G
H
L
I
N
G
Q
L
V
T
E
N
-
T
R
S
Q
N
V
F
N
P
A
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E
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G
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Q
L
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A
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A
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A
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P
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A
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L
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T
M
Q
D
A
M
D
L
I
D
A
H
E
Y
G
N
G
T
C
I
F
T
R
D
G
E
A
A
R
Y
F
S
D
N
I
Q
V
G
M
V
G
I
N
I
P
L
P
V
P
V
A
Y
H
S
F
G
G
W
K
R
S
L
F
G
D
L
H
A
Y
G
P
D
A
V
R
F
Y
T
K
R
K
T
V
T
Q
R
W
P
S
-
A
-
G
V
R
E
G
--------
31
PsiBlast_CBE
86.55
46%
-53
- C4 -
-
1T90
1
IOLA_BACSU
C:
[2-480]
-------------
E
I
R
K
L
K
N
Y
I
N
G
E
W
V
E
S
K
T
D
Q
Y
E
D
V
V
N
P
A
T
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
K
T
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
N
T
K
E
A
L
G
E
V
G
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
M
G
D
S
L
A
S
I
A
T
D
V
E
A
A
N
Y
R
Y
P
I
G
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
T
E
K
L
V
E
L
F
E
K
A
G
L
P
K
G
V
F
N
V
V
Y
G
A
H
D
V
V
N
G
I
L
E
H
P
E
I
K
A
I
S
F
V
G
S
K
P
V
G
E
Y
V
Y
K
K
G
S
E
N
L
K
R
V
Q
S
L
T
G
A
K
N
H
T
I
V
L
N
D
A
N
L
E
D
T
V
T
N
I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
V
V
-
T
-
V
E
E
G
I
--
A
--
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
D
D
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
A
R
L
V
C
D
G
R
E
N
V
S
D
D
G
Y
----
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
N
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
P
M
A
F
F
P
F
S
G
W
K
S
S
F
F
G
T
L
H
A
N
G
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
Y
------------------
1
PsiBlast_PDB
86.09
48%
-65
- C4 -
-
5TJR
1
?
A:
[38-521]
------------------
K
H
L
I
G
G
E
L
I
-
A
D
T
G
R
T
A
D
V
F
N
P
S
T
G
E
A
V
R
K
V
P
L
A
D
R
E
T
M
Q
Q
A
I
D
A
A
K
A
A
F
P
A
W
R
N
T
P
P
A
K
R
A
Q
V
L
F
R
F
K
Q
L
L
E
A
N
E
E
R
I
V
K
L
I
S
E
E
H
G
K
T
I
E
D
A
A
G
E
L
K
R
G
I
E
N
V
E
Y
A
T
A
A
P
E
I
L
K
G
E
Y
S
R
N
V
G
P
N
I
D
A
W
S
D
F
Q
P
I
G
V
V
A
G
I
T
P
F
N
F
P
A
M
V
P
L
W
M
Y
P
L
A
I
A
C
G
N
T
F
I
L
K
P
S
E
R
D
P
S
S
T
L
L
I
A
E
L
F
H
E
A
G
L
P
K
G
V
L
N
V
V
H
G
D
K
G
A
V
D
A
L
I
E
A
P
E
V
K
A
L
S
F
V
G
S
T
P
I
A
E
Y
I
Y
S
E
G
T
K
R
G
K
R
V
Q
A
L
G
G
A
K
N
H
A
V
L
M
P
D
A
D
L
D
N
A
V
S
A
L
M
G
A
A
Y
G
---
E
R
C
M
A
I
S
-
V
-
A
-
V
C
V
G
D
Q
I
A
--
D
A
L
V
Q
K
L
V
P
Q
I
K
-------------------
G
A
A
R
D
K
V
T
G
Y
I
D
T
G
V
A
Q
G
A
E
L
V
V
D
G
R
-------------
L
G
G
T
L
F
D
R
V
T
P
E
M
T
I
Y
K
E
E
I
F
G
P
V
L
C
I
V
R
V
N
S
L
E
E
A
M
Q
L
I
N
D
H
E
Y
G
N
G
T
C
I
F
T
R
D
G
E
A
A
R
L
F
C
D
E
I
E
V
G
M
V
G
V
N
V
P
L
P
V
P
V
A
Y
H
S
F
G
G
W
K
R
S
L
F
G
D
L
H
A
Y
G
P
D
G
V
R
F
Y
T
K
R
K
A
I
T
Q
R
W
P
Q
R
K
S
H
E
-----------
142
HHSearch
86.04
47%
-52
- C4 -
-
4ZZ7
-
?
K:
[5-490]
---------------
T
T
I
G
H
L
I
N
G
Q
L
V
T
E
N
-
T
R
S
Q
N
V
F
N
P
A
T
G
E
I
G
K
Q
L
D
L
A
S
T
K
T
V
E
Q
A
I
S
A
A
Q
H
A
F
P
T
W
R
N
T
P
P
L
K
R
A
R
V
M
F
R
F
K
E
L
L
E
Q
H
A
D
E
I
C
R
L
I
G
E
E
H
G
K
I
A
H
D
A
M
G
E
L
Q
R
G
I
E
N
V
E
Y
A
C
G
A
P
E
L
L
K
G
E
H
S
R
N
V
G
P
G
I
D
S
W
S
E
F
Q
P
M
G
V
V
A
G
I
T
P
F
N
F
P
V
M
V
P
L
W
M
F
P
M
A
I
V
C
G
N
C
F
V
L
K
P
S
E
R
D
P
S
S
T
L
Y
I
A
Q
L
L
Q
E
A
G
L
P
D
G
V
M
N
V
V
N
G
D
K
E
A
V
D
A
L
L
H
D
D
R
V
K
A
V
S
F
V
G
S
T
P
I
A
E
Y
I
Y
R
T
A
S
A
N
G
K
R
C
Q
A
L
G
G
A
K
N
H
A
I
V
M
P
D
A
D
M
D
N
A
V
N
Q
L
L
G
A
A
F
G
S
S
G
E
R
C
M
A
L
S
-
V
-
A
V
A
V
G
D
A
--
A
G-
D
A
L
V
S
K
M
T
Q
A
M
Q
K
L
K
V
G
P
S
T
D
S
G
N
D
F
G
P
V
I
T
R
Q
H
Q
E
K
V
I
G
Y
I
N
S
A
E
Q
Q
G
A
T
I
V
V
D
G
R
-
Q
P
K
V
P
N
H
E
N
G
F
F
V
G
G
T
L
I
D
H
V
T
P
E
M
T
S
Y
Q
E
E
I
F
G
P
V
L
Q
V
V
R
V
A
T
M
Q
D
A
M
D
L
I
D
A
H
E
Y
G
N
G
T
C
I
F
T
R
D
G
E
A
A
R
Y
F
S
D
N
I
Q
V
G
M
V
G
I
N
I
P
L
P
V
P
V
A
Y
H
S
F
G
G
W
K
R
S
L
F
G
D
L
H
A
Y
G
P
D
A
V
R
F
Y
T
K
R
K
T
V
T
Q
R
W
P
S
-
A
-
G
V
R
----------
26
PsiBlast_CBE
86.00
48%
-50
- C4 -
-
4ZZ7
1
?
I:
[4-484]
--------------
M
T
T
I
G
H
L
I
N
G
Q
L
V
T
E
N
T
R
S
-
Q
N
V
F
N
P
A
T
G
E
I
G
K
Q
L
D
L
A
S
T
K
T
V
E
Q
A
I
S
A
A
Q
H
A
F
P
T
W
R
N
T
P
P
L
K
R
A
R
V
M
F
R
F
K
E
L
L
E
Q
H
A
D
E
I
C
R
L
I
G
E
E
H
G
K
I
A
H
D
A
M
G
E
L
Q
R
G
I
E
N
V
E
Y
A
C
G
A
P
E
L
L
K
G
E
H
S
R
N
V
G
P
G
I
D
S
W
S
E
F
Q
P
M
G
V
V
A
G
I
T
P
F
N
F
P
V
M
V
P
L
W
M
F
P
M
A
I
V
C
G
N
C
F
V
L
K
P
S
E
R
D
P
S
S
T
L
Y
I
A
Q
L
L
Q
E
A
G
L
P
D
G
V
M
N
V
V
N
G
D
K
E
A
V
D
A
L
L
H
D
D
R
V
K
A
V
S
F
V
G
S
T
P
I
A
E
Y
I
Y
R
T
A
S
A
N
G
K
R
C
Q
A
L
G
G
A
K
N
H
A
I
V
M
P
D
A
D
M
D
N
A
V
N
Q
L
L
G
A
A
F
G
S
S
G
E
R
C
M
A
L
S
-
V
-
A
-
V
A
V
G
D
--
A
AG
D
A
L
V
S
K
M
T
Q
A
M
Q
K
L
K
V
G
P
S
T
D
S
G
N
D
F
G
P
V
I
T
R
Q
H
Q
E
K
V
I
G
Y
I
N
S
A
E
Q
Q
G
A
T
I
V
V
D
G
R
-
Q
P
K
V
P
N
H
E
N
G
F
F
V
G
G
T
L
I
D
H
V
T
P
E
M
T
S
Y
Q
E
E
I
F
G
P
V
L
Q
V
V
R
V
A
T
M
Q
D
A
M
D
L
I
D
A
H
E
Y
G
N
G
T
C
I
F
T
R
D
G
E
A
A
R
Y
F
S
D
N
I
Q
V
G
M
V
G
I
N
I
P
L
P
V
P
V
A
Y
H
S
F
G
G
W
K
R
S
L
F
G
D
L
H
A
Y
G
P
D
A
V
R
F
Y
T
K
R
K
T
V
T
Q
R
W
------------------
22
PsiBlast_CBE
85.87
48%
-67
- C4 -
-
5TJR
1
?
E:
[38-521]
------------------
K
H
L
I
G
G
E
L
I
-
A
D
T
G
R
T
A
D
V
F
N
P
S
T
G
E
A
V
R
K
V
P
L
A
D
R
E
T
M
Q
Q
A
I
D
A
A
K
A
A
F
P
A
W
R
N
T
P
P
A
K
R
A
Q
V
L
F
R
F
K
Q
L
L
E
A
N
E
E
R
I
V
K
L
I
S
E
E
H
G
K
T
I
E
D
A
A
G
E
L
K
R
G
I
E
N
V
E
Y
A
T
A
A
P
E
I
L
K
G
E
Y
S
R
N
V
G
P
N
I
D
A
W
S
D
F
Q
P
I
G
V
V
A
G
I
T
P
F
N
F
P
A
M
V
P
L
W
M
Y
P
L
A
I
A
C
G
N
T
F
I
L
K
P
S
E
R
D
P
S
S
T
L
L
I
A
E
L
F
H
E
A
G
L
P
K
G
V
L
N
V
V
H
G
D
K
G
A
V
D
A
L
I
E
A
P
E
V
K
A
L
S
F
V
G
S
T
P
I
A
E
Y
I
Y
S
E
G
T
K
R
G
K
R
V
Q
A
L
G
G
A
K
N
H
A
V
L
M
P
D
A
D
L
D
N
A
V
S
A
L
M
G
A
A
Y
G
----
R
C
M
A
I
S
-
V
-
A
-
V
C
V
G
D
Q
I
A
--
D
A
L
V
Q
K
L
V
P
Q
I
K
----------------------
R
D
K
V
T
G
Y
I
D
T
G
V
A
Q
G
A
E
L
V
V
D
G
R
-------------
L
G
G
T
L
F
D
R
V
T
P
E
M
T
I
Y
K
E
E
I
F
G
P
V
L
C
I
V
R
V
N
S
L
E
E
A
M
Q
L
I
N
D
H
E
Y
G
N
G
T
C
I
F
T
R
D
G
E
A
A
R
L
F
C
D
E
I
E
V
G
M
V
G
V
N
V
P
L
P
V
P
V
A
Y
H
S
F
G
G
W
K
R
S
L
F
G
D
L
H
A
Y
G
P
D
G
V
R
F
Y
T
K
R
K
A
I
T
Q
R
W
P
Q
R
K
S
H
E
-----------