@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNM0: (2017-11-17 )
MPHSKFLVQPLWVAMLAVSHSGLVFAESEKNDAETNTLHSLAPIVVTAQQGNDANGLIVHADPKQPIQPVPATDGADYLQSIMGFNSIQSGGTNGDVTFRGMFGSRIKILTDGTENLGACPNRMDAPTSYISPESYDRISVIKGPQTVQYANTGSAATVLFERQPEKLTSEKPYRGQASVLLGSYGRIDHNVEAAIGDEKKYIRLNANRSESNSYQDGDGNTVPSAWKKWNADVALGFTPDENTWVEITGGKSDGESLYAGRSMDGSQFAHESLGLRFEKKNITDVIKKIEGQVNYSYNDHIMDNFSLRTPPLVEMNHGGMTMLMPNAMAMQVTRRTLNSRLAMTSEWNKWSLITGVDSQFNKHGGSMSSPTMPSMNVPYRQDMRFQSYGAFGELGYQWNDQNKLVTGARLDRVTVEDERADSQAKGFNTKLEKNLPSAFVRWENQYPEHDFKSYIGLGYVERMPDYWELFSPKHGNAGSTNTFNGVNPEKTLQLDLGFQQQHGALNTWASAYAGLVDDYILMSYHHHPSMGMDGHDMSHDITAGAKNVDATIAGAEAGIGYQFTDRIQADLSAMYAWGKNTTDDKPLPQISPLEGRLNIRYVADKYNLGLLWRAVAEQNRVSLHQGNIVGYDLKPSKGFSTLSLNGSYNLRKDIDVSVGIDNVLDKTYTEHLNKAGSAGFGFASEEQFNNIGRNYWVRMSMKF
Atome Classification :
(20 SA)
--------------------------.........10........20........30........40........50------------.---------------------.--------....---------------------...60........70-.-.......80........90.-----.-----..-.-----...100---.-.---.------....110..-..---...120-.-.--------..-....130.......140.......150-.-----------------------.......160--.......--170-...--......180.--.-----.------.------.--.-.--190.--..--.--.---.--.-.200-........210----------------------.--...--....-.----220-----------------------.-------------.--------.......230.......240-.-..-------------....250.....-.----.-----260--.----------.----------------.-------------.----------.--------------.---------.-.----------270.-------------........280---.-.----....----.290.......300....-...310...--....320-----.-.....--...330.......340...--.----.--.----.350.......360...-------....370.-.---------------------------.-------------------------.------------.----.----.------.-------380.........390.......400........410....----------------------------.---..420..----------------------------.---....430-----.......440......-.450..------.....460---.........470.-....------------.-.480...----....490.......500.-------.-------.....510.......520.------------------......530.---..----...-----...540.---......-550........560...------....570......-.580--..-.------.-------------------.----------------------------------------....590.------.------.....600-------.----.---.-----....610.......----620...---.---.-------.--.630.....----------..640......-.650--.------.......660.......670.......680-----........690-.......700..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------MPHSK
F
L
V
Q
P
L
W
V
A
M
L
A
VSHS
G
L
V
F
A
ESEKNDAETNTLHSLA
P
I
V
V
T
A
QQ-------------G---------------------N--------DAN
G
---------------------
L
I
V
HADPKQPIQPVP-A-TD
G
A
D
Y
L
Q
S
I
MGFNSIQSGG-----T-----NG-
D
-----
V
T
F
RGM---F-G---
S
------
R
I
K
I
L
TDGT-EN---LGACP--N-R--------MD-APTSYISPESYD
R
I
S
VIKGP
Q
T
V
Q
Y
A--N-----------------------TG
S
A
A
T
V
L
F
E--RQ
P
E
K
LT--S---EKP--YRGQ
A
S
V
L
LG--S-----Y------G------R--I-D--H-NV--EA--A--I---G--D-E
K
K
--
Y
I
R
L
NANRS------------------------E--SNS--YQDG-D----G-------------------------N-------------T--------V
P
S
A
W
K
KWNA
D
V
A
L
G
FTPDE-N-
T
W
-------------
V
E
I
TGGKSDGES-L----Y-----A-G--R----------S----------------M-------------D----------
G
--------------
S
---------
Q
-
F
----------
A
--
H
-------------
E
S
LG
L
R
F
EKK
N
---
I
-
T
----
D
V
I
K
----
K
IE
G
Q
V
NYSYNDHIMDNF-SLRTP
P
L
V
E
--MNHG
G
-------
M
-
T
M
LMP--
N
A
M
A
M
Q
V
T
R
R
T
L
N
S
R
LAMT--S----E--W----N
K
W
S
L
ITGV
D
S
Q
F
N
KHG-------GSMSSP-T-M---------------------------P-------------------------S------------M----N----V------P-------
Y
--
R
QDMRFQSYGAFGEL
G
Y
Q
WND-QN
K
L
V
TGA
R
L
D
R
V
T
V----------------------------E---DERADSQ----------------------------A---KGFN
T
K
L
-----
E
KNL
P
S
A
F
V
R
WENQYP-
E
H
D
F
K
S
------
Y
I
G
L
G
Y
-----
V
E
RMP
D
Y
W
E
LFSP-KHGN------------A-GSTNTFN----GVNPE
K
T
L
Q
L
DLGF
Q
Q
QH-------G-------A
L
N
T
W
A
S
A
Y
A
G
L
V
D
D
Y
I
L
M
------------------SYHHHPS--M---GM----DGH-----DMSHDIT---AGAKNV-
D
-
A
T
IAGAEAGIGY
Q
F
T
------
D
R
I
Q
A
D
L
S
A
M
Y
AW-GK----NT-T------D-------------------D----------------------------------------KPLPQISP------L------EG
R
L
N
I
R
Y
-------
V
----A---D-----KYN
L
G
L
L
W
R
A
V
A
EQ----N
R
V
S
LH---Q---G-------
N
--
I
V
G
Y
DLKPS----------KG
F
S
T
L
S
LNGS-YN-L--R------K
D
I
D
V
S
VG
I
D
N
V
L
D
K
T
Y
T
E
H
L
N
KAGSAGF------GFA
S
E
E
Q
F
N
NI-G
R
N
Y
W
V
R
M
SMKF
47
Fugue
70.06
19%
57
- C7 -
-
4RDR
5
Y964_NEIMB
A:
[32-748]
------------------------------------------------------
S
R
P
R
A
T
S
G
L
L
H
T
---------------------------------------------
S
--------
T
A
S
D
---------------------
K
I
I
S
G
D
T
L
R
Q
----
K
-
A
-
V
N
L
G
D
A
L
D
G
V
P
G
I
H
A
S
Q
Y
G
G
-----
G
-----
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S
-
A
-----
P
V
I
R
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Q
---
T
-
G
---
R
------
R
I
K
V
L
N
H
H
G
-
E
T
GDM
A
D
F
S
P
--
D
-
H
--------
A
I
M
V
D
T
A
L
-----
S
Q
Q
V
E
I
L
R
G
P
V
T
L
L
Y
S
--
S
GNVA
G
L
V
D
V
A
D
GKIPE
K
M
P
E
NG
V
S
G
E
L
G
L
R
L
S
S
--
G
N
L
E
K
L
T
--
S
---
G
G
I
--
N
I
G
L
G
K
N
F
V
L
--
H
-----
T
------
E
------
G
--
L
-
Y
--
R
-
K
S
----------------
G
-
D
Y
A
--
V
P
R
Y
R
N
L
K
R
------------------------
L
--
P
D
S
--
H
A
D
S
-
Q
----
T
-------------------------
G
-------------
S
--------
I
G
L
S
W
V
G
E
K
G
F
I
G
V
A
Y
S
D
R
R
-
D
-
Q
Y
G
L
P
AHSHEYDDCH
A
D
I
I
W
Q
K
S
L
I
N
K
-
R
----
Y
-----
L
-
Q
--
L
YPH-------
L
----------------
L
-------------
T
----------
E
--------------
E
---------
D
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----------
D
--
Y
-------------
D
N
P
G
L
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G
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G
R
P
W
I
-
D
----
L
R
N
K
----
R
Y
E
L
R
A
E
W
K
------
Q
P
F
-
P
G
F
E
A
L
R
V
H
--
L
N
R
N
D
-------
Y
-
R
H
D
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K
AG
D
A
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N
F
F
N
N
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A
R
I
E
L
R
--
H
----
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-------
P
I
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L
K
G
S
W
G
V
Q
Y
L
Q
Q
K
-------
S
S
A
L
S
A
-
I
-
S
---------------------------
E
-------------------------
A
------------
V
----
K
----
Q
------
P
M------
L
--
L
-
D
N
K
V
Q
H
Y
S
F
F
G
V
E
Q
A
N
W
-
D
-
N
F
T
L
E
G
G
V
R
V
E
K
Q
K
A
----------------------------
S
I
Q
Y
D
K
A
L
I
D
R
----------------------------
E
---
N
Y
Y
N
H
P
L
P
DLG
A
H
R
Q
T
A
R
S
F
A
L
S
G
N
W
Y
F
-
T
P
Q
H
K
L
------
S
L
T
A
S
H
-----
Q
E
R
L
P
S
T
Q
E
L
Y
A
---
H
G
K
------------
H
-
V
A
T
N
T
F
E
V
G
N
K
H
L
N
K
E
R
S
N
N
I
E
L
A
L
G
Y
E
G
-------
D
-------
R
W
Q
Y
N
L
A
L
Y
R
N
R
F
G
N
Y
I
---------------------
Y
A
Q
T
L
N
--
D
---
G
R
----
G
P
K
-----
S
I
E
D
D
S
E
MKL
V
R
Y
N
Q
S
-
G
-
A
D
F
Y
G
A
E
G
E
I
Y
F
K
P
T
------
P
R
Y
R
I
G
V
S
G
D
Y
V
R
-
G
R
----
L
K
--------
N
-------------------
L
----------------------------------------
P
S
L
P
G
R
E
D
------
A
------
Y
G
N
R
P
F
I
A
-------
Q
----
D
---
D
-----
Q
N
A
P
R
V
P
A
A
R
L
G
F
H
----
L
K
A
S
L
T
DR
I
D
---
A
-------
N
--
L
D
Y
Y
R
V
F
A
Q
----------
N
K
L
A
R
Y
E
T
R
T
P
G
H
H
M
L
--
N
------
L
G
A
N
Y
R
R
N
T
R
Y
G
E
W
N
W
Y
V
K
A
D
N
L
L
N
Q
S
V
Y
------
A
H
S
S
F
L
S
D
T
P
Q
M
G
R
S
F
T
G
G
V
N
V
K
F
22
HHSearch
65.26
16%
52
- C7 -
-
4RDR
5
Y964_NEIMB
A:
[32-748]
---------------------------------------------------------------------------
S
-------------
R
---------------------
P
R
A
TSGLL
H
T
S
T
A
---------------------
S
D
K
I
I
S
G
D
-
T
L
R
Q
-
K
-
A
-
V
N
L
G
D
A
L
D
G
V
P
G
I
H
A
S
Q
Y
G
G
-----
G
-----
A
S
-
A
-----
P
V
I
R
G
Q
---
T
-
G
---
R
------
R
I
K
V
L
N
H
H
G
-
E
T
---
G
D
M
A
D
--
F
-
S
--------
P
--
D
H
A
I
M
V
D
T
A
L
S
Q
Q
V
E
I
L
R
G
P
V
T
L
L
Y
S
--
S
-----------------------
G
N
V
A
G
L
V
D
V
A
--
D
G
K
I
P
E
K
--
M
P
--
E
N
G
--
V
S
G
E
L
G
L
R
L
S
--
S
-----
G
------
N
------
L
--
E
-
K
--
L
T
S
G
--
G
I
--
N
--
I
---
G
--
L
G
K
N
F
--
V
L
H
T
E
G
L
Y
R
------------------------
K
--
S
G
D
--
Y
A
V
P
-
R
----
Y
-------------------------
R
NLKR---------
L
--------
P
D
S
H
A
D
S
Q
T
G
S
I
G
L
S
W
V
G
-
E
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K
-
G
F
-------------
I
G
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A
Y
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D
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Y
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----
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-----
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-
A
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----------
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----------------
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-------------
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YDDCHADIIW
Q
K
S
L
-----------
I
N
K-------
R
-
Y
----------
L
--
Q
LYPHLLTEEDIDY
D
N
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R
----
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-------
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---
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--------------------------------------
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----
K
----
Q
------
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-------
M
--
L
L
D
N
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V
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H
Y
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F
F
G
V
E
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A
N
W
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D
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N
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T
L
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G
V
R
V
E
K
Q
K
A
----------------------------
S
---
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Q
Y
D
K
A
L
I
D
R
E
N
YYN
H
-------------------
P
---
L
P
D
L
G
A
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-----
R
Q
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A
R
S
F
A
L
S
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N
W
Y
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K
L
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L
T
A
S
H
-----
Q
E
R
L
P
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A
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-
G
K
H
V
AT----------
N
-
T
F
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V
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N
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----
H
L
N
K
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R
S
N
N
I
E
L
A
L
G
Y
E
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-------
D
-------
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W
Q
Y
N
L
A
L
Y
R
N
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F
G
N
Y
I
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A
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T
L
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D
G
R
--
G
---
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S
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D
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L
V
R
Y
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G
A
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Y
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A
E
G
E
I
Y
F
K
P
T
------
P
R
Y
R
I
G
V
S
G
D
Y
V
R
-
G
R
----
L
K
-
N
------
L
P
S
L
P
G
R
EDAYG
N
R
P
F
I
A
Q
D
D
----------------------------------------
Q
N
A
P
R
V
P
A
------
A
------
R
L
G
F
H
L
K
A
-------
S
----
L
T--
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-----
R
I
D
A
N
L
D
Y
Y
R
V
F
A
Q
----
N
K
L
A
R
----------------
Y
-------
E
T
R
T
----------
P
G
H
H
M
L
N
L
G
A
N
-
Y
R
-
R
--
N
T
R
Y---
G
E
W
N
W
Y
V
K
A
D
N
L
L
N
Q
S
V
Y
A
H
S
S
F
----------------
L
S
D
T
P
Q
M
-
G
R
S
F
T
G
G
V
N
V
K
F
27
HHSearch
63.31
19%
36
- C7 -
-
2GSK
10
BTUB_ECOLI
A:
[1-590]
------------------------------------------------------------------
P
D
T
L
V
V
T
A
N
R
-------------
F
---------------------
E
Q
P
R
S----
T
V
L
A
---------------------
P
T
T
V
V
T
R
-
Q
D
I
D
R
W
Q
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S
-
T
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L
R
R
L
P
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V
D
I
T
Q
N
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G
-----
S
G
Q
---
L
S
-
S
-----
I
F
I
R
G
T
---
N
-
A
---
S
------
H
V
L
V
L
I
D
G
V
-
R
L
---
N
L
A
G
V
--
S
-
G
--------
S
--
A
D
L
S
Q
F
P
I
A
L
V
Q
R
V
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Y
I
R
G
P
R
S
A
V
Y
G
--
S
-----------------------
D
A
I
G
G
V
V
N
I
I
--
T
T
R
D
E
P
-------------
G
T
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S
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--
S
-----
N
------
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---
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-
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R
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T
L
L
G
D
Y
A
------------------------
H
--
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--
Y
D
V
V
-
A
YGNT
G
-------------------------
T
QAQ----------
T
--------
D
N
D
G
F
L
S
K
T
L
Y
G
A
L
E
H
N
F
T
D
-
A
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-------------
G
F
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R
G
Y
G
Y
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----
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D
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P
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--
S
----------
P
----------------
L
-------------
L
----------
D
T
-------------
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---------
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----------
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S
-------------
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D
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------------
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-----
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R
-------------------
Y
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Y
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Q
W
A
N
N
--
V
----
I
--
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----
G
H
G
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I
G
A
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V
D
W
Q
K
Q
T
T
T
-------
P
G
T
G
-----------------------------------------------------------------------------------------
Y
-------
V
--
E
D
G
Y
D
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T
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Y
L
T
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L
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G
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F
T
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----------------------------
F
-------------------------------------------------------
G
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F
------
I
A
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Y
G
T
-----
S
Y
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A
P
N
L
G
Q
L
Y
G
F
----------------------
Y
G
N
P
----
N
L
D
P
E
K
S
K
Q
W
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G
A
F
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G
L
T
-------
A
-------
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------------------
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H
------------------------------
T
---
L
K
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-
G
K
A
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A
T
A
N
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G
-------
P
L
T
H
T
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Y
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V
D
-
A
R
----
N
A
-
I
------
T
-------------------
D
----------------------------------------
T
P
L
L
R
R
A
K
------
Q
------
Q
V
K
Y
Q
L
D
W
-------
Q
----
L
---
Y
-----
D
F
D
W
G
I
T
Y
Q
Y
L
G
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----
Y
D
K
D
Y
S
---
S
-----------
Y
----
P
Y
Q
T
V
K
M
----------
G
G
V
S
L
W
D
L
A
V
A
-
Y
P
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V
--
T
------
S
H
L
T
V
R
G
K
I
A
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L
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D
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V
--------------------
Y
G
Y
Q
T
A
-
G
R
E
Y
T
L
S
G
S
Y
T
F
43
HHSearch
61.50
15%
34
- C7 -
-
1FEP
-
FEPA_ECOLI
A:
[11-724]
------------------------------------------------------------------
D
D
T
I
V
V
T
A
A
E
-------------
Q
---------------------
N
--------
L
Q
A
P
---------------------
G
V
S
T
I
T
A
-
D
E
I
R
K
N
P
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A
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N
L
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G
N
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SGQRG
N
-----
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Q
-----
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D
I
R
G
M
---
G
-
P
---
E
------
N
T
L
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L
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K
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P
V
---
S
S
R
N
S
--
V
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QGWRGERD
T
R
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G
D
T
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W
V
P
P
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L
R
G
P
A
A
A
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Y
G
--
N
-----------------------
G
A
A
G
G
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V
N
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--
T
K
K
G
S
G
E
-----------
W
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G
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A
Y
F
N
--
A
-----
P
EHKE
E
G
A
------
T
--
K
-
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--
T
-
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L
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--
G
---
P
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G
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T
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-------------
L
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G
N
-
L
----
Y
-----
A
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--
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----------
T
----------------
Q
NT-----------
N
----------
S
--------------
D
---------
S
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T
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S
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N
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-------------
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---
P
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L
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---------------------------
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D
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L
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N
--
L
----
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T
L
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L
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T
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N
Q
Q
R
M
K
-------
D
L
S
S
N
T
-
Q
A------------------------------------------------------------------------------------
D
-------
R
--
S
P
Y
S
K
A
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L
F
A
E
N
N
M
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L
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D
-
S
T
I
V
T
P
G
L
R
F
D
H
H
S
I
----------------------------
V
-------------------------------------------------------
G
N
N
W
S
P
A
L
N
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Q
G
L
G
-
D
-
D
F
T
L
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K
M
G
I
A
R
-----
A
Y
K
A
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L
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Q
T
N
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N
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Y
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G
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Y
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D
----
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K
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L
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K
R
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D
-------
G
W
L
A
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D
Y
R
N
K
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------------------
G
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A
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--
N
------------------
A
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---
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------
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W
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N
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L
-
K
S
----
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N
K
T
------
T
-------------------
G
----------------------------------------
D
R
L
S
I
I
P
E
------
Y
------
T
L
N
S
T
L
S
W
-------
Q
----
A
R--
E
-----
D
L
S
M
Q
T
T
F
T
W
Y
G
K
Q
----
Q
P
K
K
Y
N
---
Y
---
K
-------
G
QP
A
V
G
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T
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----------
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P
Y
S
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L
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A
T
-
W
D
-
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--
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------
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N
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S
L
T
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G
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D
N
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N
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Y
T
Y
N
E
P
-
G
R
T
W
Y
M
S
V
N
T
H
F
21
HHSearch
61.07
15%
46
- C7 -
-
3FHH
1
?
A:
[2-640]
-------------------------------------------------------------------
E
T
M
T
V
T
A
T
G
-------------
N
---------------------
A
RSSF----
E
A
P
M
---------------------
M
V
S
V
I
D
T
-
S
A
P
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T
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A
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A
T
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L
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L
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T----
N
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-----
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---
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P
A
L
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R
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R
G
P
S
A
L
L
Y
G
--
S
-----------------------
G
A
L
G
G
V
I
S
Y
D
--
T
V
D
A
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D
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--
L
---
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--
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-----
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------
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------
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---
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--
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N
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G
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A
W
S
S
R
------------------------
D
--
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--
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Q
S
-
N
----
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-------------------------
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-------------
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--------
A
P
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N
N
M
L
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S
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A
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-------------
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L
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Y
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----------------
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VEASESS---
N
--------------
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-----
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----------
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G
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R
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G
-------
S
H
------------------------------------------------------------------------------------
T
------
T
-------
G
--
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A
K
I
D
F
S
S
G
W
L
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D
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I
T
L
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D
L
P
I
T
L
L
G
G
T
R
Y
D
S
Y
R
G
----------------------------
S
---
S
D
G
---------------------------------------
Y
K
D
V
-----
D
A
D
K
W
S
S
R
A
G
M
T
I
N
P
T
-
N
-
W
L
M
L
------
F
G
S
Y
A
Q
-----
A
F
R
A
P
T
M
G
E
M
Y
N
D
-
S
K
H
F
SIGRF
Y
------
T
-
N
Y
W
V
P
N
P
----
N
L
R
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L
R
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D
DLMLSN
D
-------
A
L
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A
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Y
F
D
T
K
A
K
D
Y
I
S
T
------------------
T
V
D
F
A
A
--------------------------
A
T
---
T
M
S
Y
N
V
-
P
N
A
K
I
W
G
W
D
V
M
T
K
Y
T
T
-------
D
L
F
S
L
D
V
A
Y
N
R
T
R
-
G
K
----
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T
-
D
------
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-------------------
G
----------------------------------------
E
Y
I
S
S
I
N
P
------
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------
T
V
T
S
T
L
N
I
-------
P
----
I
---
A
HS---
G
F
S
V
G
W
V
G
T
F
A
D
R
S
----
T
H
I
S
---------
S
-----------------
K
Q
----------
P
G
Y
G
V
N
D
F
Y
V
S
-
Y
Q
-
G
--
Q
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AL---
K
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T
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T
L
V
L
G
N
A
F
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Y
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P
--------------------
Q
G
I
P
Q
D
-
G
R
N
G
K
I
F
V
S
Y
Q
W
25
HHSearch
60.74
17%
60
- C7 -
-
5FR8
1
?
B:
[27-733]
---------------------------------------------------------------------
I
F
V
T
A
E
E
-------------
Q
---------------------
V
--------
K
Q
S
L
---------------------
G
V
S
V
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L
E
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L
P
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R
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L
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TGQRG
N
-----
N
R
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---
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P
---
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------
N
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K
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P
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---
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S
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T
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--
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-----------------------
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--
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K
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-----------
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--
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-----
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------
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DSKEGS
S
--
N
-
R
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F
-
N
V
--
S
G
--
P
--
L
---
I
--
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L
--
S
Y
R
L
Y
G
N
Y
N
------------------------
K
--
T
E
A
DD
V
D
I
N
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K
----
S
IGST---------------------
A
-------------
A
--------
G
R
E
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N
K
D
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G
R
L
A
W
Q
A
T
D
-
Q
-
Q
T
-------------
V
L
L
D
I
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S
S
K
Q
G
N
-
I
----
Y
-----
S
-
G
--
D
----------
S
Q---------------
L
-------------
N
----------
A
--------------
N
AEADAILSQ
L
-
I
GKETNTM---
Y
--
R
-------------
D
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Y
A
L
T
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D
-----------
W
S
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----
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------
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-------
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--
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N
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KDSSG----------------------
S
G------------------------
Y
------------
G
----
D
QLA-
K
------
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-------
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--
R
S
K
M
E
S
R
I
A
S
A
Y
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E
D
N
L
K
V
T
D
-
S
T
D
V
V
L
G
L
R
F
D
D
H
S
K
-----------------------------------------------------------------------------------
S
G
S
N
W
S
P
S
L
N
I
T
Q
K
L
N
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D
-
Y
F
T
L
------
K
G
G
V
A
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-----
A
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N
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L
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TNGNGCPANIES
R
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L
L
Q
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N
G
----
D
L
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P
E
T
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K
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G
I
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Q
K
-------
D
-------
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V
N
A
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L
T
W
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R
N
D
Y
K
D
K
I
V
A
------------------
G
T
H
V
V
G
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G
SST
N
A
----
N
T
G
AV---
T
N
T
K
W
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---
L
R
W
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N
T
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P
K
A
L
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Q
G
F
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G
S
L
G
L
D
F
G
-------
D
I
R
W
T
N
N
F
T
Y
M
M
D
S
K
----
D
K
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Q
------
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-------------------
G
----------------------------------------
N
P
L
S
L
V
P
I
------
Y
------
T
I
N
S
I
F
D
Y
-------
D
----
I
T--
D
-----
Q
L
D
V
N
F
V
F
T
Q
Y
G
R
Q
----
K
S
R
Q
F
A
---
E
NRL
E
SGIGSGG
A
--
N
S
A
L
K
P
S
T
V
----------
K
S
Y
S
T
A
G
I
N
V
G
-
Y
K
-
F
--
S
------
D
Q
I
S
T
R
V
G
V
S
N
L
F
D
K
Q
I
L
R
D
S
N
S
---------------
I
S
Q
T
Y
N
E
P
-
G
R
A
Y
Y
A
S
L
K
Y
S
F
42
HHSearch
60.36
15%
33
- C7 -
-
1KMO
17
FECA_ECOLI
A:
[114-774]
--------------------------------------------------------------------
A
L
T
V
V
G
D
W
-------------
L
GDAR
E
N
D
V
-------------
F
--------
E
H
A
G
---------------------
A
R
D
V
I
R
R
-
E
D
F
A
K
T
G
-
A
-
T
T
M
R
E
V
L
N
R
I
P
G
V
S
A
P
E
N
N
G
-----
T
GSHDL
A
M
-
N
-----
F
G
I
R
G
L
---
N
-
P
RLA
S
------
R
S
T
V
L
M
D
G
I
-
P
V
---
P
F
A
P
Y
--
G
-
Q
--------
P
Q
-
L
S
L
A
P
V
S
L
G
N
M
D
A
I
D
V
V
R
G
G
G
A
V
R
Y
G
--
P
-----------------------
Q
S
V
G
G
V
V
N
F
V
--
T
R
A
I
P
Q
D
--
F
---------
G
I
E
A
G
V
E
G
Q
--
L
S
PTSS
Q
------
N
------
N
P
K
E
-
T
--
H
-
N
L
--
M
V
--
G
--
G
---
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A
-
D
-
N
G
F
--
G
T
A
L
L
Y
S
G
T
------------------------
R
--
G
S
D
--
W
R
E
H
---------------------------------------------------------
S
A
T
R
I
D
D
L
M
L
K
S
K
Y
A
P
D
E
-
V
-
H
T
-------------
F
N
S
L
L
Q
Y
Y
D
G
E
A
-
D
----
M
-----
P
-
G
--
G
----------
L
----------------
S
R
A
D
Y
---------
D
----------
A
--------------
D
RWQSTR---
P
-
Y
D
R
F
W
G
-----
R
--
R
-------------
K
L
A
S
L
G
Y
Q
F
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P
-----
D
----
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Q
H
-----
K
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N
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Q
G
F
Y
T
Q
T
L
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G
--
Y
-
L
E
Q
G
K
---------------------------
R
I
T
L
S
P
R
N
Y
W
V
R
G
I
E
P
R
Y
S
Q
I
F
----
M
--
I
GP--
S
A
H
E
V
G
V
G
Y
R
Y
L
N
E
S
T
H
-------
E
M
R
Y
Y
T
A
T
-
S
SGQL-----------------------
P
-------------------------
S
------------
G
----
S
----
S
------
P
-------
Y
D
R
D
T
R
S
G
T
E
A
H
A
W
Y
L
D
D
K
I
D
I
G
--
N
W
T
I
T
P
G
M
R
F
E
H
I
E
S
----------------------------
Y
---
Q
N
N
A
I
----------------------------------
T
G
T
H
E
E
V
-----
S
Y
N
A
P
L
P
A
L
N
V
L
Y
H
L
T
-
D
-
S
W
N
L
------
Y
A
N
T
E
G
-----
S
F
G
T
V
Q
Y
S
Q
I
G
K
A
----------------------
V
Q
S
G
----
N
V
E
P
E
K
A
R
T
W
E
L
G
T
R
Y
D
D
-------
G
-------
A
L
T
A
E
M
G
L
F
L
I
N
F
N
N
Q
Y
D
S
------------------
N
Q
T
N
---------------------------------
D
T
V
T
A
R
G
K
-
T
R
H
T
G
L
E
T
Q
A
R
Y
D
L
G
TLTPTL
D
N
V
S
I
Y
A
S
Y
A
Y
V
N
-
A
E
----
I
R
-
E
KGDT--
Y
-------------------
G
----------------------------------------
N
L
V
P
F
S
P
K
------
H
------
K
G
T
L
G
V
D
Y
-------
K
----
P
---
G
-----
N
W
T
F
N
L
N
S
D
F
Q
S
S
Q
----
F
A
D
N
A
N
---
T
---
V
-------
K
E-
S
A
D
G
S
T
G
R
I
----------
P
G
F
M
L
W
G
A
R
V
A
-
Y
D
-
F
--
G
PQM---
A
D
L
N
L
A
F
G
V
K
N
I
F
D
Q
D
Y
F
I
R
S
Y
D
D
N
-------------
N
K
G
I
Y
A
G
Q
-
P
R
T
L
Y
M
Q
G
S
L
K
F
26
HHSearch
58.04
19%
33
- C7 -
-
2GUF
16
BTUB_ECOLI
A:
[3-594]
----------------------------------------------------------------
T
S
P
D
T
L
V
V
T
A
N
R
-------------
F
---------------------
E
Q
P
RS----
T
V
L
A
---------------------
P
T
T
V
V
T
R
-
Q
D
I
D
R
W
Q
-
S
-
T
S
V
N
D
V
L
R
R
L
P
G
V
D
I
T
----------Q----
L
S
-
S
-----
I
F
I
R
G
T
---
N
-
A
---
S
------
H
V
L
V
L
I
D
G
V
-
R
L
---
N
L
A
G
V
--
S
-
G
--------
S
--
A
D
L
S
Q
F
P
I
A
L
V
Q
R
V
E
Y
I
R
G
P
R
S
A
V
Y
G
--
S
-----------------------
D
A
I
G
G
V
V
N
I
I
--
T
T
R
D
E
P
-------------
G
T
E
I
S
A
G
W
G
--
S
-----
N
------
S
------
Y
--
Q
-
N
--
Y
-
D
V
--
S
T
--
Q
--
Q
---
Q
--
L
G
D
K
T
--
R
V
T
L
L
G
D
Y
A
------------------------
H
--
T
H
----------------------------------------------------------------
D
G
F
L
S
K
T
L
Y
G
A
L
E
H
N
F
T
D
-
A
-
W
S
-------------
G
F
V
R
G
Y
G
Y
D
N
R
T
-
N
----
Y
---------------------------------------------------------------
D
T
-------------
R
---------
K
-
L
----------
Y
S
Q
S
-------------
W
D
A
G
L
R
Y
N
G
E
L
------------
I
-----
K
S
Q
L
I
T
S
Y
S
H
S
K
D
Y
N
--
Y
-
D
-
P
H
Y
G
R
-------------------
Y
-----
D
S
S
A
T
L
D
E
M
K
Q
Y
T
V
Q
W
A
N
N
--
V
----
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--
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----
G
H
G
S
I
G
A
G
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K
Q
T
T
T
-------
P
G
T
G
-----------------------------------------------------------------------------------------
Y
-------
V
--
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G
Y
D
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R
N
T
G
I
Y
L
T
G
L
Q
Q
V
-
G
-
D
F
T
F
E
G
A
A
R
S
D
D
N
S
Q
----------------------------
F
-------------------------------------------------------
G
R
H
G
T
W
Q
T
S
A
G
W
E
F
I
-
E
-
G
Y
R
F
------
I
A
S
Y
G
T
-----
S
Y
K
A
P
N
L
G
Q
L
Y
G
F
----------------------
Y
G
N
P
----
N
L
D
P
E
K
S
K
Q
W
E
G
A
F
E
G
L
T
-------
A
-------
G
V
N
W
R
I
S
G
Y
R
N
D
V
S
D
L
I
D
Y
------------------
D
D
H
------------------------------
T
---
L
K
Y
Y
N
E
-
G
K
A
R
I
K
G
V
E
A
T
A
N
F
D
T
G
-------
P
L
T
H
T
V
S
Y
D
Y
V
D
-
A
R
----
N
A
-
I
------
T
-------------------
D
----------------------------------------
T
P
L
L
R
R
A
K
------
Q
------
Q
V
K
Y
Q
L
D
W
-------
Q
----
L
---
Y
-----
D
F
D
W
G
I
T
Y
Q
Y
L
G
T
R
----
Y
D
K
D
Y
S
---
S
-----------
Y
----
P
Y
Q
T
V
K
M
----------
G
G
V
S
L
W
D
L
A
V
A
-
Y
P
-
V
--
T
------
S
H
L
T
V
R
G
K
I
A
N
L
F
D
K
D
Y
----------------------------
A
-
G
R
E
Y
T
L
S
G
S
Y
T
F
46
Fugue
57.44
14%
35
- C7 -
-
1KMO
17
FECA_ECOLI
A:
[114-774]
----------------------------------------------
A
L
T
V
V
G
D
W
L
G
D
A
R
E
N
D
V
F
E
H
A
G
A
R
D
V
I
R
R
E
-------------
D
---------------------
F
--------
A
K
T
G
-------------------------------------
A
-
T
T
M
R
E
V
L
N
R
I
P
G
V
S
A
P
E
N
N
G
-----
T
-----
G
S
-
H
DL
A
M
N
F
G
I
R
G
L
NPR
L
-
A
---
S
------
R
S
T
V
L
M
D
G
I
-
P
V
---
P
F
A
P
Y
--
G
-
Q
--------
P
Q
-
L
S
L
A
P
V
S
L
G
N
M
D
A
I
D
V
V
R
G
G
G
A
V
R
Y
G
PQ
S
-----------------------
V
G
G
V
V
N
F
V
T
R
--
A
I
P
Q
D
F
G
--
I
---
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A
G
--
V
E
G
Q
L
S
P
T
S
S
--
Q
-----
N
------
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------
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--
K
-
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--
T
-
H
N
--
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M
--
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G
G
T
---
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--
D
-
N
G
F
--
G
T
A
L
L
Y
S
G
T
------------------------
R
--
G
S
D
--
W
R
E
H
---------------------------------------------------------
S
A
T
R
I
D
D
L
M
L
K
S
K
Y
A
P
D
E
-
V
-
H
T
-------------
F
N
S
L
L
Q
Y
Y
D
G
E
A
-
D
----
M
-----
P
G
G
--
L
----------
S
----------------
R
-------------
A
----------
D
--------------
Y
---------
D
-
A
----------
D
--
R
-------------
W
Q
S
T
R
P
Y
D
R
F
W
---
G
-
R
----
R
K
L
A
----
S
L
G
Y
Q
F
Q
P
D
S
Q
H
K
F
N
I
Q
G
-
F
Y
T
Q
T
L
R
S
G
--
Y
L
E
Q
G
-------
K
-
R
I
T
L
S
--
P
-
R
N
Y
W
V
R
G
I
E
P
R
Y
S
Q
I
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M
--
I
----
G
--
P
----
S
A
H
E
V
G
V
G
Y
R
Y
L
N
E
S
T
H
-------
E
M
R
Y
Y
T
-
A
-
T
---------------------------
S
-------------------------
S
------------
G
----
Q
----
L
------
P
SGSSPYD
R
--
D
T
R
S
G
T
E
A
H
A
W
Y
L
D
D
K
I
D
I
G
N
--
W
T
I
T
P
G
M
R
F
E
H
I
E
S
----------------------------
Y
---
Q
N
N
A
I
T
G
-------------------------------------------------
T
H
E
E
V
S
Y
N
A
P
L
-
P
A
L
N
V
L
------
Y
H
L
T
D
S
-----
W
N
L
Y
A
N
T
E
G
S
F
G
T
V
Q
Y
S
Q
------------
I
-
G
K
A
V
Q
S
G
----
N
V
E
P
E
K
A
R
T
W
E
L
G
T
R
Y
D
D
-------
G
-------
A
L
T
A
E
M
G
L
F
-
L
I
N
F
N
N
Q
Y
D
------------------
S
N
Q
T
N
D
T
--
V
---
T
A
----
R
G
K
-----
T
R
H
T
G
------------
L
-
E
T
Q
A
R
Y
D
L
G
T
L
T
P
T
L
------
D
N
V
S
I
Y
A
S
Y
A
Y
V
N
-
A
E
I
REK
G
D
-
T
------
Y
-------------------
G
----------------------------------------
N
L
V
P
F
S
P
K
------
H
------
K
G
T
L
G
V
D
Y
-------
K
----
P
---
G
-----
N
W
T
F
N
L
N
S
D
F
Q
S
S
Q
FADN
A
N
T
V
K
E
---
S
---
A
-------
D
--
G
S
T
G
R
I
P
G
F
----------
M
L
W
G
A
R
V
A
Y
D
F
-
G
P
-
Q
--
M
------
A
D
L
N
L
A
F
G
V
K
N
I
F
D
Q
D
Y
F
I
R
S
Y
D
D
N
N
K
G
I
------
Y
A
G
Q
--------
P
R
T
L
Y
M
Q
G
S
L
K
F
29
HHSearch
57.33
17%
59
- C7 -
-
3CSL
3
?
B:
[113-865]
----------------------------------------------------------------------------------------------------------------NDWVY---
D
E
P
R
---------------------
S
V
S
V
I
S
R
-
E
Q
M
D
N
R
P
-
A
-
R
H
A
A
D
I
L
E
Q
T
T
G
A
Y
S
S
V
S
Q
Q
D----
P
-----
A
L
-
S
-----
V
N
I
R
G
I
---
Q
D
Y
---
G
------
R
V
N
M
N
I
D
G
M
-
R
Q
---
N
F
Q
K
S
--
G
H
G
--------
Q
R
-
N
G
T
M
Y
I
D
S
E
L
L
S
G
V
T
I
D
K
G
T
T
G
G
M
G
S
--
A
-----------------------
G
T
L
G
G
I
A
T
F
N
--
T
V
S
A
S
D
F
LA
P
---
G
K
E
--
L
G
G
K
L
H
A
S
T
G
--
D
-----
N
------
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------
T
--
H
-
F
I-
G
-
S
G
--
I
L
--
A
--
L
---
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--
N
-
E
T
G
--
D
I
L
L
A
A
S
E
R
------------------------
H
--
L
G
D
--
Y
W
P
G
-
N
----
K
GDIGNIRINNDTGNYDRYAESIKNN
K
-------------
I
--------
P
D
T
H
Y
R
M
H
S
R
L
A
K
V
G
W
N
L
P
A
-
N
-
Q
R
-------------
L
Q
L
S
Y
L
Q
T
Q
T
A
S
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P
----
I
-----
A
-
G
--
T
----------
L
----------------
T
-------------
N
LGTRPPYE--
L
GWKR----------
T
---------
G
Y
T
----------
D
VM
A
-------------
R
N
A
A
F
D
Y
S
L
A
P
---
E
-
D
----
V
D
W
L
----
D
F
Q
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K
L
Y
Y
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D
T
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D
D
S
D
T
Y
-
S
T
S
S
L
L
-----------------------
D
--
N
G
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A
T
R
T
R
L
R
T
Y
G
A
Q
A
Q
N
T
--
S
----
R
FS
L
APG-
H
D
F
R
A
N
Y
G
L
E
F
Y
Y
D
K
A
T
-------
S
D
S
S
R
Q
----------------------------------------------------------------------
G
----
M
----
E
------
G
-------
V
--
T
P
A
G
N
R
S
V
A
S
L
F
A
N
L
T
Y
D
Y
D
G
-
W
L
T
L
E
G
G
L
R
Y
D
R
Y
R
L
----------------------------
R
---
G
Q
T
G
L
S
Y
PDLAKDGQRYTIDNPCKALRLTGCSTTT
R
---
E
D
W
D
V
D
R
-----
D
Q
G
K
L
S
P
T
L
A
V
A
V
R
P
G
V
E
-
W
L
E
L
------
Y
T
T
Y
G
K
-----
S
W
R
P
P
A
I
T
E
T
L
T
N
-
G
S
A
H
------------
S
S
S
T
Q
Y
P
N
P
----
F
L
Q
P
E
R
S
R
A
W
E
V
G
F
N
V
Q
Q
PDLWFEG
D
-------
R
L
V
A
K
V
A
Y
F
D
T
K
V
D
N
Y
I
N
L
------------------
A
I
D
R
N
K
P
--
G
---
L
-----
V
-------
Q
P
S
I
G
N
A
---
A
Y
V
N
N
L
-
S
K
T
R
F
R
G
L
E
Y
Q
L
N
Y
D
A
G
-------
V
F
Y
A
D
L
T
Y
T
H
M
I
-
G
K
----
N
E
-
F
------
C
-------------------
S
NKAWLGGRLRYGDGSRRGNFYVEPDAASNDFVTCDGGTQF
G
S
A
A
Y
L
P
G
------
D
------
R
G
S
V
T
L
G
G
-------
R
----
A
FD-
R
-----
K
L
D
A
G
V
T
V
R
F
A
P
G
Y
----
Q
D
S
S
V
P
---
S
-----------
N
----
Y
P
Y
L
A
D
W
----------
P
K
Y
T
L
F
D
L
Y
A
S
-
Y
K
-
L
--
T
------
D
S
L
T
L
R
G
S
V
E
N
L
T
N
R
A
Y
V
V
S
Y
G
E
---------------
T
L
A
N
T
L
G
R
-
G
R
T
V
Q
G
G
V
E
Y
R
F
28
HHSearch
57.27
15%
45
- C7 -
-
4B7O
-
?
A:
[61-745]
--------------------------------------------------------------------------
D
R
-------------
Q
---------------------
G
---------
S
K
I
---------------------
R
T
N
I
V
T
L
-
Q
Q
K
D
E
S
T
-
A
-
T
D
M
R
E
L
L
K
E
E
P
S
I
D
F
G
G
G
N
G
-----
T
-----
S
Q
-
F
-----
L
T
L
R
G
M
---
G
-
Q
---
N
------
S
V
D
I
K
V
D
N
A
-
Y
S
---
D
S
Q
I
L
--
Y
-
H
-----------
Q
G
R
F
I
V
D
P
A
L
V
K
V
V
S
V
Q
K
G
A
G
S
A
S
A
G
--
I
-----------------------
G
A
T
N
G
A
I
I
A
K
--
T
V
D
A
Q
D
L
--
L
KGL
D
K
N
--
W
G
V
R
L
N
S
G
F
A
--
S
-----
N
------
E
------
G
--
V
-
S
--
Y
-
G
A
--
S
V
--
F
--
G
---
K
--
E
-
G
N
F
--
D
G
L
F
S
Y
N
R
N
------------------------
D
--
E
K
E
--
Y
E
A
G
-
K
----
G
-------------------------
F
-------------
R
NFNGGKTV
P
Y
S
A
L
D
K
R
S
Y
L
A
K
I
G
T
T
F
G
D
G
D
-
H
R
-------------
I
V
L
S
H
M
E
D
Q
H
R
--
G
----
I
-----
R
-
T
--
V
----------
R
----------------
E
EF-----------
T
V----------------------------------
P
-
Y
R
E
T
-------
T
--
Q
-------------
S
N
T
N
L
A
Y
T
G
K
D
---
L
-
G
-----
F
V
E
----
K
L
D
A
N
A
Y
V
L
E
K
K
R
Y
S
A
D
---
D
K
D
N
G
--------------------
Y
A
G
N
--
V
V
G
P
N
H
T
R
I
T
T
R
G
M
N
F
N
F
D
--
S
----
R
--
L
A---
E
Q
T
L
L
K
Y
G
I
N
Y
R
H
Q
E
I
K
-------
P
Q
A
F
L
N
-
G
-
E
---------------------------
F
EISTDEEK
A
K
D
K
K
D
M
D
---------
L
------------
V
----
H
----
S
------
Y
-------
K
--
L
S
N
P
T
K
T
D
T
G
A
Y
I
E
A
I
H
E
L
-
D
-
G
F
T
L
T
G
G
L
R
Y
D
R
F
K
V
----------------------------
K
---
T
H
D
---------------------------------------
G
K
T
V
-----
S
S
S
N
L
N
P
S
F
G
V
I
W
Q
P
H
-
E
-
H
W
S
F
------
S
S
S
H
N
Y
-----
A
S
R
S
P
R
L
Y
D
A
L
Q
T
-
H
G
K
-------------
R
-
G
I
I
S
I
A
D
----
G
T
K
A
E
R
A
R
N
T
E
I
G
F
N
Y
N
D
-------
G
-------
T
F
A
A
N
G
S
Y
F
W
Q
T
I
K
D
A
L
A
N
------------------
P
Q
N
-----------------------------
A
V
---
R
E
A
V
N
A
-
G
Y
I
K
N
H
G
Y
E
L
G
A
S
Y
R
T
-------
G
G
L
T
A
K
V
G
V
S
H
S
K
-
P
R
----
F
Y
-
D
------
T
HP-----------------
K
----------------------------------------
K
L
L
S
A
N
P
E
------
F
GAQV
G
R
A
W
T
A
S
L
A
Y
-------
R
----
F
---
Q
NP---
N
L
E
I
G
W
R
G
R
Y
V
Q
K
A
----
V
G
S
I
L
V
---
A
G
Q
K
D
-------
R
----
K
L
E
N
V
V
R
----------
K
G
F
G
V
N
D
V
F
A
N
-
W
K
-
P
LG
K
------
D
T
L
N
V
N
L
S
V
N
N
V
F
N
T
F
Y
Y
P
H
S
Q
R
---------------
W
T
N
T
L
P
G
V
-
G
R
D
V
R
L
G
V
N
Y
K
F
45
Fugue
56.87
14%
52
- C7 -
-
3CSL
6
?
A:
[113-865]
-----------------------------------------------------
N
D
W
V
Y
D
E
P
R
S
V
S
V
I
------------------------------------------------------------------------------------
S
R
E
Q
M
D
N
R
P
-
A
-
R
H
A
A
D
I
L
E
Q
T
T
G
A
Y
S
S
V
S
Q
Q
-----
D
-----
P
A
L
S
-----
V
N
I
R
G
I
---
Q
-
D
Y--
G
------
R
V
N
M
N
I
D
G
M
R
Q
N
---
F
Q
K
S
G
--
H
-
G
--------
Q
R
-
N
G
T
M
Y
I
D
S
E
L
L
S
G
V
T
I
D
K
G
T
T
G
G
M
G
S
--
A
-----------------------
G
T
L
G
G
I
A
T
F
N
T
V
S
A
S
D
F
L
A
--
P
---
G
K
E
--
L
G
G
K
L
H
A
S
T
G
--
D
-----
N
------
G
------
T
--
H
-
F
--
I
-
G
S
--
G
I
--
L
--
A
---
L
--
G
-
N
E
T
G
D
I
L
L
A
A
S
E
R
H
L
G
DYWPGNKGDIGNIRINNDTGN
Y
D
--
R
Y
A
--
E
S
I
K
-
N
----
N
-------------------------
K
-------------
I
--------
P
D
T
H
Y
R
M
H
S
R
L
A
K
V
G
W
N
L
P
A
-
N
-
Q
R
-------------
L
Q
L
S
Y
L
Q
T
Q
T
A
S
-
P
----
I
-----
A
-
G
--
T
----------
L
----------------
T
-------------
N
----------
L
--------------
G
---------
T
-
R
----------
P
--
P
-------------
Y
E
L
G
W
---
K
R
T
---
G
-
Y
----
T
D
V
M
----
A
R
N
A
A
F
D
Y
S
L
A
P
E
D
V
D
W
L
-
D
F
Q
A
K
L
Y
Y
V
--
D
T
Q
D
D
-------
S
-
D
T
Y
S
T
--
S
S
L
L
D
N
G
Y
A
T
R
T
R
L
R
T
Y
G
A
--
Q
----
A
--
Q
----
N
T
S
R
F
S
L
A
P
G
H
D
F
R
A
N
Y
-------
G
L
E
F
Y
Y
-
D
-
K
---------------------------
A
-------------------------
T
------------
S
----
D
----
S
SRQGME
G
-------
V
--
T
P
A
G
N
R
S
V
A
S
L
F
A
N
L
T
Y
D
Y
D
G
-
W
L
T
L
E
G
G
L
R
Y
D
R
Y
R
L
R
G
Q
T
G
L
S
Y
PDLAKDGQRYTIDNPCKALR
L
---
T
G
C
S
T
T
T
----------------------------
R
---
E
D
W
D
V
D
R
-----
D
Q
G
K
L
S
P
T
L
A
V
A
V
R
P
G
-
V
E
W
L
E
L
------
Y
T
T
Y
G
K
-----
S
W
R
P
P
A
I
T
E
T
L
T
N
-
G
S
A
H
------------
S
-
S
S
T
Q
Y
P
N
P---
F
L
Q
P
E
R
S
R
A
W
E
V
G
F
N
V
Q
Q
-------
P
DLWFEG
D
R
L
V
A
K
V
A
Y
F
D
T
K
V
D
N
Y
I
N
L
AIDRNKPG
L
V
Q
P
S
IGN
A
A
Y
V
N
N
L
S
K
--
T
---
R
F
----
R
G
L
-----
E
Y
Q
L
N
Y
D
---
A
G
V
F
Y
A
-
D
-
L
T
Y
T
H
M
I
-
G
K
N
E
F
C
S
------
N
K
A
W
L
G
G
R
L
R
Y
G
D
-
G
S
----
R
R
-
G
------
N
-------------------
F
YV--------------------------------------
E
P
D
A
A
S
N
D
------
F
------
V
T
C
D
G
G
T
Q
FGSAAYL
P
----
G
---
D
-----
R
G
S
V
T
L
G
G
R
A
F
D
R
K
----
L
D
A
G
V
T
---
V
---
R
-------
F
--
A
P
G
Y
Q
D
S
S
V
PSNYPYLADW
P
K
Y
T
L
F
D
L
Y
A
S
-
Y
K
-
L
--
T
------
D
S
L
T
L
R
G
S
V
E
N
L
T
N
R
A
Y
V
V
S
Y
G
E
T
L
A
N
---------------
T
L
G
R
-
G
R
T
V
Q
G
G
V
E
Y
R
F
24
HHSearch
56.20
14%
47
- C7 -
-
4EPA
2
FYUA_YERPE
A:
[17-654]
------------------------------------------------------------------------
T
A
S
K
-------------
Q
---------------------
S
SRSAS---
A
N
N
V
---------------------
S
S
T
V
V
S
A
-
P
E
L
S
D
A
G
-
V
-
T
A
S
D
K
L
P
R
V
L
P
G
L
N
I
E
N
S
G
N
-----
M
L----
F
S
-
T
-----
I
S
L
R
G
V
---
S
-
S
---
A
QDFYNP
A
V
T
L
Y
V
D
G
V
-
P
Q
---
L
S
T
N
--------------------
T
I
Q
A
L
T
D
V
Q
S
V
E
L
L
R
G
P
Q
G
T
L
Y
G
--
K
-----------------------
S
A
Q
G
G
I
I
N
I
V
--
T
Q
Q
P
D
S
T
-----------
P
R
G
Y
I
E
G
G
V
S
--
S
-----
R
------
D
------
S
--
Y
-
R
--
S
-
K
F
--
N
L
--
S
--
G
---
P
IQ
D
-
G
L
L
--
Y
G
S
V
T
L
L
R
Q
------------------------
V
--
D
D
G
--
D
M
I
N
P
A
T---
G
-------------------------
S
-------------
D
--------
D
L
G
G
T
R
A
S
I
G
N
V
K
L
R
L
A
P
D
D
-
Q
P
W
E
-------------
M
G
F
A
A
S
R
E
C
T
R
A
-
T
----
Q
-----
D
-
A
YV
G
WN--------
D
----------------
I
-------------
K
GRKLSISDGS
P
--------------
D
---------
P
-
Y
M
R
R
-------
C
--
T
-------------
D
S
Q
T
L
S
G
K
Y
T
T
----------
D
D
W
-----
V
F
N
L
I
S
A
W
Q
Q
Q
H
Y
S
R
T
-
F
-
P
-
S
G
S
L
I
----------------------
V
---
N
M
P
Q
R
W
N
Q
D
V
Q
E
L
R
A
A
T
L
--
G
----
D
--
A
----
R
T
V
D
M
V
F
G
L
Y
R
Q
N
T
R
E
K
-------
L
N
S
A
Y
D
-
M
-
P
---------------------------
T
-------------------------
M
------------
P
----
Y
----
L
------
S
-------
S
--
T
G
Y
T
T
A
E
T
L
A
A
Y
S
D
L
T
W
H
L
T
D
-
R
F
D
I
G
G
G
V
R
F
S
H
D
K
S
----------------------------
S
---
T
Q
Y
H
G
S
M
----------------------------
L
G
N
P
F
G
D
Q
G
K
S
-----
N
D
D
Q
V
L
G
Q
L
S
A
G
Y
M
L
T
-
D
-
D
W
R
V
------
Y
T
R
V
A
Q
-----
G
Y
K
P
S
G
Y
N
I
V
P
T
A
---------------------
G
L
D
A
K
----
P
F
V
A
E
K
S
I
N
Y
E
L
G
T
R
Y
E
T
-------
A
-------
D
V
T
L
Q
A
A
T
F
Y
T
H
T
K
D
M
Q
L
--------------------------------------------------------
Q
T
L
S
N
A
-
G
K
A
D
A
T
G
V
E
L
E
A
K
W
R
F
A
------
P
G
W
S
W
D
I
N
G
N
V
I
R
-
S
E
----
F
T
-
N
DSELY-
H
-------------------
G
----------------------------------------
N
R
V
P
F
V
P
R
------
Y
------
G
A
G
S
S
V
N
G
-------
V
----
I
---
D
TRY
G
-
A
L
M
P
R
L
A
V
N
L
V
G
P
H
----
Y
F
D
G
D
----------------
N
-------
Q
L
R
Q
----------
G
T
Y
A
T
L
D
S
S
L
G
-
W
Q
-
A
--
T
------
E
R
M
N
I
S
V
Y
V
D
N
L
F
D
R
R
Y
R
T
Y
G
Y
M
N
G
------------
S
S
A
V
A
Q
V
N
M
-
G
R
T
V
G
I
N
T
R
I
D
F
23
HHSearch
55.62
15%
42
- C7 -
-
4AIP
1
?
B:
[60-742]
-------------------------------------------------------------------------
G
D
R
-------------
Q
---------------------
G
---------
S
K
I
---------------------
R
T
N
I
V
T
L
-
Q
Q
K
D
E
S
T
-
A
-
T
D
M
R
E
L
L
K
E
E
P
S
I
D
F
G
G
G
N
G
-----
T
-----
S
Q
-
F
-----
L
T
L
R
G
M
---
G
-
Q
---
N
------
S
V
D
I
K
V
D
N
A
-
Y
S
---
D
S
Q
I
L
--
Y
-
H
-----------
Q
G
R
F
I
V
D
P
A
L
V
K
V
V
S
V
Q
K
G
A
G
S
A
S
A
G
--
I
-----------------------
G
A
T
N
G
A
I
I
A
K
--
T
V
D
A
Q
D
L
--
L
K
GL
D
K
N
--
W
G
V
R
L
N
S
G
F
A
--
S
-----
N
------
N
------
G
--
V
-
S
--
Y
-
G
A
--
S
V
--
F
--
G
---
K
--
E
-
G
N
F
--
D
G
L
F
S
Y
N
R
N
------------------------
D
--
E
K
D
--
Y
E
A
G
-
K
----
G
-------------------------
F
-------------
R
NVNGGKTV
P
Y
S
A
L
D
K
R
S
Y
L
A
K
I
G
T
T
F
G
D
D
D
-
H
R
-------------
I
V
L
S
H
M
K
D
Q
H
R
--
G
----
I
-----
R
-
T
--
V
----------
R
----------------
E
EFTVGDKSSRINI
D
RQ--------
A
--------------
P
---------
A
-
Y
R
E
T
-------
T
--
Q
-------------
S
N
T
N
L
A
Y
T
G
K
N
---
L
-
G
-----
F
V
E
----
K
L
D
A
N
A
Y
V
L
E
K
E
R
Y
S
A
---
D
D
S
G
T
G
--------------------
Y
A
G
N
--
V
K
G
P
N
H
T
R
I
T
T
R
G
A
N
F
N
F
D
--
S
----
R
--
L
A---
E
Q
T
L
L
K
Y
G
I
N
Y
R
H
Q
E
I
K
-------
P
Q
A
F
L
N
-
S
-
K
FS----------------------------------------------------EQQ
M
K
D
R
A
D
E
D
T
V
----
H
----
A
------
Y
-------
K
--
L
S
N
P
T
K
T
D
T
G
V
Y
I
E
A
I
H
D
I
G
--
D
F
T
L
T
G
G
L
R
Y
D
R
F
K
V
----------------------------
K
---
T
H
D
---------------------------------------
G
K
T
V
-----
S
S
S
N
L
N
P
S
F
G
V
I
W
Q
P
H
-
E
-
H
W
S
F
------
S
A
S
H
N
Y
-----
A
S
R
S
P
R
L
Y
D
A
L
Q
T
-
H
G
K
-------------
R
-
G
I
I
S
I
A
D
----
G
T
K
A
E
R
A
R
N
T
E
I
G
F
N
Y
N
D
-------
G
-------
T
F
A
A
N
G
S
Y
F
W
Q
T
I
K
D
A
L
A
N
------------------
P
Q
N
R
--------------------------
S
V
A
V
---
R
E
A
V
N
A
-
G
Y
I
K
N
H
G
Y
E
L
G
A
S
Y
R
T
-------
G
G
L
T
A
K
V
G
V
S
H
S
K
-
P
R
----
F
Y
-
D
TH----
K
-------------------
D
----------------------------------------
K
L
L
S
A
N
P
E
FGAQVG
R
------
T
W
T
A
S
L
A
Y
-------
R
----
F
QN-
P
-----
N
L
E
I
G
W
R
G
R
Y
V
Q
K
A
----
T
G
S
I
L
A
---
A
---
G
Q
K
-----
D
R-
K
G
N
L
E
N
V
V
R
----------
K
G
F
G
V
N
D
V
F
A
N
-
W
K
-
P
--
L
GK----
D
T
L
N
V
N
L
S
V
N
N
V
F
N
K
F
Y
Y
P
H
S
Q
R
---------------
W
T
N
T
L
P
G
V
-
G
R
D
V
R
L
G
V
N
Y
K
F
38
HHSearch
55.37
15%
52
- C7 -
-
5FP1
8
?
A:
[18-718]
--------------------------------------------------------------------------
T
Q
EESLKVDQSANSK
F
VAPL-----------------
L
--------
D
T
P
K
---------------------
S
V
S
V
I
S
K
-
Q
L
I
E
D
T
K
-
V
-
T
T
L
A
D
A
L
R
T
V
P
G
I
T
L
G
A
G
E
G
GNP--
N
-----
G
D
-
R
-----
P
F
I
R
G
Y
---
S
-
S
----------
E
S
S
M
Y
I
D
G
I
-
R
N
---
S
T
S
Q
---------------------
N
R
E
M
F
A
V
E
Q
V
E
V
T
K
G
S
A
S
A
M
G
G
--
A
-----------------------
G
S
V
G
G
S
I
N
M
I
--
S
K
V
A
K
K
G
--
D
---------
F
L
E
G
S
V
A
A
G
--
T
-----
D
------
N
------
Y
--
Q
-
R
--
I
-
T
L
--
D
G
--
N
--
K
---
D
--
F
G
N
G
I
--
A
A
R
V
A
V
L
G
H
------------------------
Q
--
N
E
K
--
A
---------
G
-------------------------
Q
-------------
S
--------
N
G
A
E
Y
K
R
V
G
I
A
P
S
I
T
F
G
L
D
T
-
P
-
T
R
-------------
A
T
L
S
Y
Y
Y
L
Q
T
D
D
-
K
P
D
S
G
I
-----
P
-
Y
--
W
D
SSLGKAQGK
P
----------------
A
EVKQGTYYGW---
K
----------
D
--------------
R
---------
D
-
F
Q
K
Q
-------
E
--
N
-------------
H
I
G
T
I
K
L
E
H
D
L
-----
T
----
D
N
I
-----
T
I
T
N
T
A
M
Y
A
K
S
K
N
D
Y
V
W
--
T
N
P
D
D
S
K
G
N
-----
V
G
-------
K
-
G
L
V
W
H
--
R
L
N
S
A
I
T
D
S
E
T
F
T
D
Q
L
A
L
T
--
G
----
K
--
F
D
TGF
L
K
H
R
F
N
V
G
A
E
Y
S
K
Q
K
T
D
-------
K
G
G
Y
N
I
-
I
-
D
AKGNVSSTGFYSDCSDLSTNWCTSLNG
P
-------------------------
T
Q
K
P
---------
F
----
V
D
R
L
Q
A
------
R
-------
P
--
D
F
D
A
T
V
E
S
T
S
V
Y
L
L
D
N
I
E
I
T
P
-
K
W
L
L
D
L
G
L
R
W
D
K
F
E
A
----------------------------
E
---
Q
N
F
L
A
T
S
----------------------------
S
A--
A
A
Y
T
A
K
N
-----
N
S
D
F
V
T
Y
Q
A
G
I
T
F
K
P
T
-
E
-
N
G
S
I
------
Y
T
S
Y
A
T
-----
S
A
S
P
V
G
L
N
A
G
W
G
D
-
N
S
E
---------------
T
I
N
A
N
N
Q
----
M
I
D
P
E
E
A
Q
T
F
E
I
G
T
K
W
D
F
-------
L
DN-----
H
L
N
L
T
A
A
I
F
R
T
E
K
Q
N
T
R
V
Q
------------------
I
D
P
----------------------------------
T
T
Y
A
N
V
-
G
E
S
K
V
D
G
F
E
L
G
L
N
G
E
I
T
------
D
K
W
N
I
S
A
G
Y
T
Y
L
D
-
S
E
----
L
T
-
K
------
N
G
K
S
C
R
SG
K
C
T
D
QSIYN---
G
----------------------------------------
N
Q
M
P
N
V
P
K
------
Q
------
A
A
T
L
W
T
T
Y
-------
K
----
V
L--
P
-----
Q
L
T
V
G
A
G
A
V
Y
S
D
K
V
----
Y
G
D
V
A
----------------
N
-------
T
K
W
V
----------
P
S
Y
V
R
Y
D
A
M
A
R
-
Y
N
-
V
--
N
------
K
N
V
D
L
Q
L
N
I
N
N
L
S
D
K
R
Y
F
T
K
A
Y
A
---------------
S
H
Y
A
T
E
A
E
-
G
R
S
A
V
L
A
V
N
F
K
Y
31
HHSearch
54.81
14%
43
- C7 -
-
1FI1
8
FHUA_ECOLI
A:
[6-707]
-------------------------------------------------------------
P
A
A
T
I
A
A
R
Q
S
A
T
G
T
K
-------------
T
---------------------
D
TPIQ----
K
V
P
Q
---------------------
S
I
S
V
V
T
A
-
E
E
M
A
L
H
Q
-
P
-
K
S
V
K
E
A
L
S
Y
T
P
G
V
S
V
G
T
R
G
A
-----
S
NT---
Y
D
-
H
-----
L
I
I
R
G
F
---
A
-
A
---
E
GQ----
S
Q
N
N
Y
L
N
G
L
-
K
L
---
Q
G
N
F
-----------------
Y
N
D
A
V
I
D
P
Y
M
L
E
R
A
E
I
M
R
G
P
V
S
V
L
Y
G
--
K
-----------------------
S
S
P
G
G
L
L
N
M
V
--
S
K
R
P
T
T
E
-----------
P
L
K
E
V
Q
F
K
A
G
--
T
-----
D
------
S
------
L
--
F
-
Q
--
T
-
G
F
--
D
F
--
S
D
S
L
---
D
--
D
D
G
V
Y
--
S
Y
R
L
T
G
L
A
R
------------------------
S
--
A
N
A
--
Q
Q
K
---------------------------------------------------------
G
S
E
E
Q
R
Y
A
I
A
P
A
F
T
W
R
P
D
D
-
K
-
T
N
-------------
F
T
F
L
S
Y
F
Q
N
E
P
E
T
G
----
Y
-----
Y
-
G
--
W
----------
L
P
KEGTVEPLPNG
K
R
L
P
T
-------------
D
FNEGAK----
N
--------------
N
---------
T
-
Y
----------
S
R
N
E
-------------
K
M
V
G
Y
S
F
D
H
E
----
F
-
N
----
D
T
F
-----
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
N
S
V
Y
G
Y
G
V
C
S
D
P
A
NA
Y
S
K
Q
C
AALAPAD
K
G
H
Y
L
A
R
--
K
Y
V
V
D
D
E
K
L
Q
N
F
S
V
D
T
Q
L
Q
--
S
----
K
--
F
A
TGD
I
D
H
T
L
L
T
G
V
D
F
M
R
M
R
N
D
-------
I
N
A
W
F
G
-
Y
D
D
---------------------------
S
V
P
L
L
NLYNPSSHHHHHHG
S
S
V
N
T
D
F
D
------------
F
NAKD
P
AN
S
-
G
------
P
-------
Y
--
R
I
L
N
K
Q
K
Q
T
G
V
Y
V
Q
D
Q
A
Q
W
-
D
-
K
V
L
V
T
L
G
G
R
Y
D
W
A
D
Q
----------------------------
E
---
S
L
N
R
V
----------------------------------
A
G
T
T
D
K
R
-----
D
D
K
Q
F
T
W
R
G
G
V
N
Y
L
F
D
-
N
-
G
V
T
P
------
Y
F
S
Y
S
E
-----
S
F
E
P
S
S
Q
V
G
K
-------------------------
D
G
N
I
-----
F
A
P
S
K
G
K
Q
Y
E
V
G
V
K
Y
V
P
-------
E
DR-----
P
I
V
V
T
G
A
V
Y
N
L
T
K
T
N
N
L
M
A
------------------
D
P
E
G
-----------------------------
S
---
F
F
S
V
E
G
-
G
E
I
R
A
R
G
V
E
I
E
A
K
A
A
L
S
------
A
S
V
N
V
V
G
S
Y
T
Y
T
D
-
A
E
----
Y
T
-
T
DTTY--
K
-------------------
G
----------------------------------------
N
T
P
A
Q
V
P
K
------
H
------
M
A
S
L
W
A
D
Y
-------
T
----
F
---
F
DGPLS
G
L
T
L
G
T
G
G
R
Y
T
G
S
S
----
Y
G
D
P
A
----------------
N
-------
S
F
K
V
----------
G
S
Y
T
V
V
D
A
L
V
R
-
Y
D
-
L
--
A
RVGM--
A
G
S
N
V
A
L
H
V
N
N
L
F
D
R
E
Y
V
A
S
C
F
N
---------------
T
Y
G
C
F
W
G
A
-
E
R
Q
V
V
A
T
A
T
F
R
F
48
Fugue
54.45
13%
60
- C7 -
-
2IAH
1
FPVA_PSEAE
A:
[1-772]
Q
E
V
E
F
D
I
P
P
QA
L
G
S
A
L
Q
E
F
G
R
Q
A
D
I
Q
V
L
Y
R
P
E
E
V
R
N
K
R
S
S
A
I
K
G
K
L
E
P
N
Q
A
I
T
E
L
L
R
G
T
G
A
S
V
D
F
Q
G
N
A
I
T
I
S
V
A
T
-------------
I
---------------------
T
--------
E
D
S
G
SYTPGTIATATRLVLTPRETP
Q
S
I
T
V
V
T
R
Q
N
M
D
D
F
G
-
L
-
N
N
I
D
D
V
M
R
H
T
P
G
I
T
V
S
A
Y
D
T
-----
D
-----
R
N
-
N
-----
Y
Y
A
R
G
F
---
S
-
I
---
N
--------
N
F
Q
Y
D
G
I
-
P
S
---
T
A
R
-
N
--
V
-
G
--------
Y
S
-
A
G
N
T
L
S
D
M
A
I
Y
D
R
V
E
V
L
K
G
A
T
G
L
L
T
G
--
A
-----------------------
G
S
L
G
A
T
I
N
L
I
--
R
K
K
------
P
---
T
H
E
--
F
K
G
H
V
E
L
G
A
G
--
S
-----
W
------
D
------
N
--
Y
-
R
--
S
-
E
L
--
D
V
--
S
--
G
P
LT
E
--
S
-
G
N
V
--
R
G
R
A
V
A
A
Y
Q
------------------------
D
--
K
H
S
--
F
M
D
H
---------------------------------------------------------
Y
E
R
K
T
S
V
Y
Y
G
I
L
E
F
D
L
N
P
-
D
-
T
M
-------------
L
T
V
G
A
D
Y
Q
D
N
D
P
-
K
----
G
-----
S
-
G
--
W
----------
S
----------------
G
-------------
S
----------
F
--------------
P
---------
L
-
F
----------
D
--
S
-------------
Q
G
N
R
N
D
V
S
R
S
F
---
N
-
N
GAKW
S
S
W
E
----
Q
Y
T
R
T
V
F
A
N
L
E
H
N
F
A
N
G
W
-
V
G
K
V
Q
L
D
H
K
--
I
N
G
Y
H
-------
A
-
P
L
G
A
I
--
M
G
D
W
P
A
P
D
N
S
A
K
I
V
A
Q
K
Y
T
--
G
----
E
--
T
----
K
S
N
S
L
D
I
Y
L
T
G
P
F
Q
F
L
G
R
E
H
E
L
V
V
G
T
S
A
S
F
-
S
-
H
---------------------------
W
-------------------------
E
------------
G
----
K
----
S
------
Y
-------
W
--
N
L
R
N
Y
D
N
T
T
D
D
F
I
N
W
D
G
D
I
G
K
-
P
D
W
G
T
P
S
Q
Y
I
D
D
K
T
R
----------------------------
Q
---
L
G
S
Y
M
T
A
----------------------------
R
---
F
N
V
T
D
D
L
-----
N
L
F
L
G
G
R
V
V
D
Y
R
V
T
G
L
-
N
P
T
I
R
E
S
G
R
F
I
P
Y
V
G
A
V
Y
D
LND
T
Y
S
V
Y
A
S
Y
T
D
I
F
M
P
-
Q
D
S
W
------------
Y
-
R
D
S
S
N
-
K
----
L
L
E
P
D
E
G
Q
N
Y
E
I
G
I
K
G
E
Y
-------
L
-------
D
----
G
R
L
N
T
S
L
A
Y
F
E
I
H
E
------------------
E
N
R
A
E
E
D
--
A
---
L
Y
----
N
S
K
-----
P
T
N
P
A
I
T
---
Y
A
Y
K
G
I
-
K
-
A
K
T
K
G
Y
E
A
E
I
S
G
E
L
A
------
P
G
W
Q
V
Q
A
G
Y
T
H
K
I
-
I
R
----
D
D
-
S
------
G
-------------------
K
----------------------------------------
K
V
S
T
W
E
P
Q
------
D
------
Q
L
S
L
Y
T
S
Y
-------
K
F
K
G
A
L
---
D
-----
K
L
T
V
G
G
G
A
R
W
Q
G
K
S
----
W
Q
M
V
Y
N
---
N
---
P
-------
R
--
S
R
W
E
K
F
S
Q
E
-----------
D
Y
W
L
V
D
L
M
A
R
-
Y
Q
-
I
--
T
------
D
K
L
S
A
S
V
N
V
N
N
V
F
D
K
T
Y
Y
T
N
I
G
F
Y
T
S
A
S
Y
------
G
D
P
----------
R
N
L
M
F
S
T
R
W
D
F
41
HHSearch
53.02
13%
44
- C7 -
-
3QLB
2
?
A:
[73-748]
-----------------------------------------------------------------------------------------
P
DSAT
G
P
Q
A
G
YVAKRSLSGTKT
D
ASLS----
E
I
P
Q
---------------------
S
I
S
V
I
T
R
-
D
Q
M
D
A
Q
Q
-
V
-
Q
S
V
N
E
A
L
R
Y
T
A
G
V
Q
A
N
T
T
A
A
SQ---
R
-----
F
D
-
T
-----
L
S
I
R
G
F
---
D
-
V
----------
T
T
G
M
L
R
D
G
L
-
K
G
---
N
T
A
Q
------------------
A
W
P
K
V
E
A
Y
G
L
E
R
I
D
V
L
K
G
P
A
S
V
L
F
G
--
Q
-----------------------
N
S
P
G
G
V
V
N
Q
I
--
S
K
R
P
L
D
K
-----------
P
F
H
E
V
Q
I
Q
G
G
--
S
-----
F
------
D
------
R
--
A
-
Q
--
G
-
Q
F
--
D
F
S
G
P
--
L
---
D
D-
E
-
G
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F
--
L
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R
L
V
G
L
E
R
------------------------
D
--
S
G
T
--
Q
F
D
H
---------------------------------------------------------
I
K
D
D
K
Q
Y
F
A
P
S
F
T
W
K
P
N
D
-
D
-
T
S
-------------
L
T
L
L
A
D
Y
T
Q
D
T
F
-
G
----
A
-----
P
-
R
--
V
----------
F
LPAQGT----------
L
-------------
L
----------
G
NPNGKVRHNVFLDE
P
---------
G
-
L
DN--------
D
--
R
T
Q
-----------
Y
S
L
G
Y
L
L
E
H
R
----
L
-
N
----
D
V
W
-----
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L
N
S
S
A
R
Y
G
H
V
N
L
L
T
N
T
A
-
S
G
M
-
S
L
A
P
D
---
L
R
---------
T
-
L
N
R
A
A
--
Y
R
F
R
I
V
G
D
T
Y
S
L
D
N
N
A
Q
A
R
--
W
----
N
--
L
GS--
T
Q
M
V
S
L
L
G
I
D
Y
R
R
T
R
E
D
-------
Y
Y
L
R
G
G
S
A
-
S
---------------------------
P
IDIY
N
P
V
H
H
H
HGVFD----------
P
------------
S
----
T
----
P
------
F
-------
T
--
N
T
V
Q
R
A
D
Q
V
G
V
Y
A
Q
Q
Q
F
T
F
D
E
-
H
W
V
L
T
V
G
G
R
Q
D
R
S
S
A
----------------------------
R
---
T
D
N
R
M
N
----------------------------------
D
S
G
S
K
Q
-----
D
D
E
K
F
T
Y
R
T
G
L
V
Y
L
A
D
-
N
-
G
L
A
P
------
Y
I
S
Y
S
T
-----
S
F
D
P
V
L
G
T
N
F
--------------------------
Y
G
T
----
P
Y
K
P
T
S
A
K
Q
S
E
V
G
V
K
Y
Q
P
-------
P
GI-----
D
S
Y
I
T
L
S
L
F
D
L
T
Q
E
N
V
L
T
T
------------------
D
P
A
Q
-----------------------------
R
---
L
N
K
I
Q
T
-
G
E
I
N
V
R
G
I
E
L
E
G
K
A
S
L
A
------
R
G
L
D
L
L
A
A
L
T
Y
N
D
-
A
E
----
V
S
-
K
SNNPLE
K
-------------------
G
----------------------------------------
K
R
P
T
D
T
P
E
------
K
------
M
A
S
L
W
A
D
Y
-------
T
----
L
---
P
E
GPLS
G
L
G
F
G
A
G
V
R
Y
I
G
S
T
----
E
A
D
A
A
----------------
N
-------
T
Q
R
V
----------
P
S
Y
T
L
L
D
A
A
V
H
-
Y
D
-
F
--
D
KLIPAA
K
G
L
R
L
A
V
N
A
T
N
L
T
D
K
H
Y
Y
E
G
C
S
L
----------------
T
N
C
S
A
G
Y
-
D
R
S
V
I
A
S
L
R
Y
R
W
39
HHSearch
52.89
17%
59
- C7 -
-
2HDI
2
CIRA_ECOLI
A:
[7-639]
-------------------------------------------------------------------
E
T
M
V
V
T
A
S
S
-------------
V
---------------------
E
Q
N
LK----
D
A
P
A
---------------------
S
I
S
V
I
T
Q
-
E
D
L
Q
R
K
P
-
V
-
Q
N
L
K
D
V
L
K
E
V
P
G
V
Q
L
T
N
E
G
D
-----
N
-----
R
K
-
G
-----
V
S
I
R
G
L
---
D
-
S
---
S
------
Y
T
L
I
L
V
D
G
K
-
R
V
---
N
S
R
N
A
VF
R
-
H
--------
N
D
-
F
D
L
N
W
I
P
V
D
S
I
E
R
I
E
V
V
R
G
P
M
S
S
L
Y
G
--
S
-----------------------
D
A
L
G
G
V
V
N
I
I
--
T
K
K
I
G
Q
K
--
W
---------
S
G
T
V
T
V
D
T
T
I
Q
E
HRD
R
-
G
------
D
------
T
--
Y
-
N
--
G
-
Q
F
F
T
S
G
--
P
--
L
---
I
--
D
-
G
V
L
--
G
M
K
A
Y
G
S
L
A
------------------------
K
R
E
K
D
D
---------------------------------------------------------------
E
G
F
S
S
R
D
G
N
V
E
F
A
W
T
P
N
Q
-
N
-
H
D
-------------
F
T
A
G
Y
G
F
D
R
Q
D
R
-
D
----
S
------------------------------------------------------------------------------
N
---------
R
-
L
----------
E
--
R
-------------
Q
N
Y
S
V
S
H
N
G
R
-------------
W
D
----
Y
G
T
S
E
L
K
Y
Y
G
E
K
--
V
E
N
--
K
--
N
P
G
---------------------------
N
S
-
S
P
I
T
S
E
S
N
T
V
D
G
K
Y
T
--
L
----
P
--
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TA--
I
N
Q
F
L
T
V
G
G
E
M
R
H
D
K
M
S
-------
D
A
V
N
L
----------------------------------------------------------------------------
T
----
G
------
G
-------
T
--
S
S
K
T
S
A
S
Q
Y
A
L
F
V
E
D
E
W
R
I
F
E
-
P
L
A
L
T
T
G
V
R
M
D
D
H
E
T
-----------------------------------------------------------------------------------
Y
G
E
H
W
S
P
R
A
Y
L
V
Y
N
A
T
-
D
-
T
V
T
V
------
K
G
G
W
A
T
-----
A
F
K
A
P
S
L
L
Q
L
S
P
D
-
W
T
S
N
S
CRG--------
A
-
C
K
I
V
G
S
P
----
D
L
K
P
E
T
S
E
S
W
E
L
G
L
Y
Y
M
G
E
E
GWL--
E
-------
G
V
E
S
S
V
T
V
F
R
N
D
V
K
D
R
I
S
I
------------------
S
R
T
S
D
V
N
--
A
---
A
P
GYQN
F
V
G
F
E
T
G
A
N
G
R
R
I
P
V
---
F
S
Y
Y
N
V
-
N
K
A
R
I
Q
G
V
E
T
E
L
K
I
P
F
N
------
D
E
W
K
L
S
I
N
Y
T
Y
N
D
-
G
R
----
D
V
-
S
NG----
E
-------------------
N
----------------------------------------
K
P
L
S
D
L
P
F
------
H
------
T
A
N
G
T
L
D
W
-------
K
----
P
LAL
E
-----
D
W
S
M
Y
M
S
G
H
Y
T
G
Q
K
-----------------------------------------------
G
G
Y
T
I
W
N
T
G
A
A
-
W
Q
-
V
--
T
------
K
D
V
K
L
R
A
G
V
L
N
L
G
D
K
D
L
S
R
------------------------
N
E
D
-
G
R
R
Y
F
M
A
V
D
Y
R
F
40
HHSearch
52.72
13%
47
- C7 -
-
3QLB
2
?
B:
[73-748]
-----------------------------------------------------------------------------------------
P
DSAT
G
P
Q
A
G
YVAKRSLSGTKT
D
ASLS----
E
I
P
Q
---------------------
S
I
S
V
I
T
R
-
D
Q
M
D
A
Q
Q
-
V
-
Q
S
V
N
E
A
L
R
Y
T
A
G
V
Q
A
N
T
T
A
A
SQ---
R
-----
F
D
-
T
-----
L
S
I
R
G
F
---
D
-
V
----------
T
T
G
M
L
R
D
G
L
-
K
G
---
N
T
A
Q
------------------
A
W
P
K
V
E
A
Y
G
L
E
R
I
D
V
L
K
G
P
A
S
V
L
F
G
--
Q
-----------------------
N
S
P
G
G
V
V
N
Q
I
--
S
K
R
P
L
D
K
-----------
P
F
H
E
V
Q
I
Q
G
G
--
S
-----
F
------
D
------
R
--
A
-
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--
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-
Q
F
--
D
F
S
G
P
--
L
---
D
D-
E
-
G
Q
F
--
L
Y
R
L
V
G
L
E
R
------------------------
D
--
S
G
T
--
Q
F
D
H
---------------------------------------------------------
I
K
D
D
K
Q
Y
F
A
P
S
F
T
W
K
P
N
D
-
D
-
T
S
-------------
L
T
L
L
A
D
Y
T
Q
D
T
F
-
G
----
A
-----
P
-
R
--
V
----------
F
L
P
AQGT----------
L
-------------
L
----------
G
NPNGKVRHNVFLDE
P
---------
G
-
L
D
N
--------
D
--
R
T
Q
-----------
Y
S
L
G
Y
L
L
E
H
R
----
L
-
N
----
D
V
W
-----
S
L
N
S
S
A
R
Y
G
H
V
N
L
L
T
N
T
A
-
S
G
M
-
S
L
A
P
D
---
L
R
---------
T
-
L
N
R
A
A
--
Y
R
F
R
I
V
G
D
T
Y
S
L
D
N
N
A
Q
A
R
--
W
----
N
--
L
GS--
T
Q
M
V
S
L
L
G
I
D
Y
R
R
T
R
E
D
-------
Y
Y
L
R
G
G
S
A
-
S
---------------------------
P
I
D
IY
N
P
V
H
HVFD-------------
P
------------
S
----
T
----
P
------
F
-------
T
--
N
T
V
Q
R
A
D
Q
V
G
V
Y
A
Q
Q
Q
F
T
F
D
E
-
H
W
V
L
T
V
G
G
R
Q
D
R
S
S
A
----------------------------
R
---
T
D
N
R
M
N
----------------------------------
D
S
G
S
K
Q
-----
D
D
E
K
F
T
Y
R
T
G
L
V
Y
L
A
D
-
N
-
G
L
A
P
------
Y
I
S
Y
S
T
-----
S
F
D
P
V
L
G
T
N
F
--------------------------
Y
G
T
----
P
Y
K
P
T
S
A
K
Q
S
E
V
G
V
K
Y
Q
P
-------
P
GI-----
D
S
Y
I
T
L
S
L
F
D
L
T
Q
E
N
V
L
T
T
------------------
D
P
A
Q
-----------------------------
R
---
L
N
K
I
Q
T
-
G
E
I
N
V
R
G
I
E
L
E
G
K
A
S
L
A
------
R
G
L
D
L
L
A
A
L
T
Y
N
D
-
A
E
----
V
S
-
K
SNNPLE
K
-------------------
G
----------------------------------------
K
R
P
T
D
T
P
E
------
K
------
M
A
S
L
W
A
D
Y
-------
T
----
L
---
P
E
GPLS
G
L
G
F
G
A
G
V
R
Y
I
G
S
T
----
E
A
D
A
A
----------------
N
-------
T
Q
R
V
----------
P
S
Y
T
L
L
D
A
A
V
H
-
Y
D
-
F
--
D
KLIPAA
K
G
L
R
L
A
V
N
A
T
N
L
T
D
K
H
Y
Y
E
G
C
S
L
----------------
T
N
C
S
A
G
Y
-
D
R
S
V
I
A
S
L
R
Y
R
W