@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNT7: (2017-11-17 )
MSEQEKKTPLLHIENLRVSFKGEDKQYIETVKGISFDIPTNTTVALVGESGSGKSVTSLATMGLLPVGQSKIDEKSKIIFEGKDLLGLSRTEMRKICGKDIAMIFQEPMSSLNPVFTVGNQIAEVLCLHMGMSRKQARQRVLELLKEVGIPSPETKIDAYPNQLSGGQQQRVMIAMAIACEPKLLIADEPTTALDVTIQKQIIDLLESLRQRRQMSMLFITHDLALVGEIADQVIVMRHGEIREQGTAEQVLEQPKDVYTRALLYCRPQMSQRPYRLPVTSDFMRQENNILVEQSFDVSEIPERKRGLNGDEKIILEVKDLKKSFYSRKGLFGKEEFQVVKGVSFKLAKGKTLGLVGESGSGKTTVGLLLMRLHQASGGQALIEGKDILSLTEKEFAKYQRKIQIIFQNPYASLNPRFTIGQILLEPMQIHGIGKDDAERKQIALGLLERVNLLEQAYYRYPHEFSGGQRQRIAIARCLTLKPEILICDESVSALDVSVQAQVLNLLQDLQDEFGLSYIFISHDLSVVKYISDQVMVMNHGEVVEIANSDELYAHPQYDYTKRLLQAIPQGIQHVS
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130-........140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260---------------.---------.---------..-----------------..---.------------------------------------.-----------------------------------.270...-------------------------------------------------..------------------------------------...-----------280------..-----------...--------------.--.--------------------------------..290-.--------------------------------------------------------.-----------.---------------.----------------------------------------------------------------.--------------.----------------------------------------------.300---------------------.---.---------------------------------------------...-------.------...310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450...----------.----------....460.......470.......480.......490.......500.......510.......520.......530.......540.......550..-.....560.....-----..570....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSEQEKKT
P
L
L
H
I
E
N
L
R
V
S
FKGE
D
K
Q
Y
I
E
T
VKG
I
S
F
DIPTN
T
T
V
A
L
V
GESGSGKSV
T
S
L
A
T
MGLLPVGQSKIDEK
S
K
I
I
FEGKDLLGL
S
R
T
E
M
R
K
I
C
G
K
D
I
A
M
I
F
Q
E
P
M
S
SLN
P
V
F
T
V
G
N
Q
I
A
E
V
L
C
L
HMG--M
S
R
K
Q
A
R
Q
R
V
L
E
L
L
K
EVGIPSPETKIDAYPNQLSGGQ
Q
Q
R
V
M
I
A
M
A
IACE
P
K
L
L
I
ADEPT
T
A
L
D
V
T
I
Q
K
Q
I
I
D
L
L
E
S
L
R
Q
R
R
Q
M
S
M
L
F
I
T
H
D
L
A
L
V
G
E
I
A
D
Q
V
I
V
MRHGEIREQG
T
A
E
Q
V
L
EQ
P
K
D
V
Y
T
-----------------
R
---------
A
---------
L
L
-----------------
Y
C---R------------------------------------P-----------------------------------QMS-QRP-------------------------------------------------YR------------------------------------LPV-----------
T
--------
S
D
-----------
F
M
R--------------Q--E--------------------------------N
N
I
L
V
-E--------------------------------------------------------Q-----------S---------------F----------------------------------------------------------------
D
--------------
V
----------------------------------------------
S
E
-----------------------
I
---
P
---------------------------------------------
E
R
K-------R------GLNGD
E
K
I
I
L
E
V
K
D
L
K
K
S
F
Y
S
RKGLF
G
K
E
E
F
Q
V
VKG
V
S
F
K
LAKG
K
T
L
G
L
VGESGSG
K
T
T
V
G
L
L
L
M
R
L
HQASG
G
Q
A
L
IEG
K
D
I
L
S
L
T
E
K
E
F
A
K
Y
Q
R
K
I
Q
I
I
F
QNPYASLNPRF
T
I
G
Q
I
L
L
E
P
M
Q
I
HGIGK
D
D
A
E
R
K
Q
I
A
L
G
L
L
E
R
V
-
N
L
L
----------
E
----------
Q
A
Y
Y
RYPHEFSGG
Q
R
Q
R
I
A
I
A
R
C
LTLKP
E
I
L
I
CDESVS
A
L
D
V
S
V
Q
A
Q
V
L
N
L
L
Q
D
L
Q
D
EFG
L
S
Y
I
F
I
SH
D
L
S
V
V
K
Y
ISD
Q
V
M
V
MNHG
E
V
V
E
IANSDE
L
Y
A-HP
Q
Y
D
Y
T
K
R
L
L
Q
A
-----
I
P
Q
G
IQHVS
123
HHSearch
76.12
25%
-20
- C2 -
-
5KO2
-
MDR1A_MOUSE
B:
[385-1232]
-------
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
--
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
-----
D
-
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
----
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
--
F
-
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
DE
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
-
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
Q
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
--
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
-
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
-----------------
L
VMTQT-----DVPPASFWR
I
L
-----------------
K
L
---
N
STEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFT
N
-----------------------------------
G
G
P
-
P
E
T
-------------------------------------------------
Q
R
QNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILT
K
R
L
RYMVFKSMLRQ
D
--------
V
S
-----------
W
F
D
DPKNTTGALTTRLA
N
--
D
AAQVKGATGSRLAVIFQNIANLGTGIIISLIY
G
W
Q
L
T
-
L
LLLAIVPIIAIAGVVEMKMLSGQALK------------------------------
D
KKEL-------
E
GSGKIATEAIENFRT
V
VSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTF
E
--------------
N
VLLVFSAIVFGAMA--------------------------------
V
G
QVSSFAPDYAKATVSASHIIRII
E
---
K
---------------------------------------------
T
P
E
IDSYSTQ
G
------
L
K
P
N
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
T
R
------
P
S
I
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
---
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
--
L
F
-
D
C
S
I
A
E
N
I
A
Y
G
D
N
S
R
V
V
S
------
Y
E
E
I
V
R
A
A
K
E
A
-
N
I
H
QFIDSLPDKY
N
----------
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
Q
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
-
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
-
Q
K
G
I
Y
F
S
M
-------------------
124
HHSearch
70.36
27%
-23
- C2 -
-
4F4C
2
PGP1_CAEEL
A:
[413-1306]
-------
K
G
D
I
T
V
E
N
V
H
F
T
Y
P
S
R
--
P
D
V
P
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
-----
K
-
G
K
I
T
I
D
G
V
D
V
R
D
I
N
L
E
----
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
--
F
-
N
C
T
I
E
E
N
I
S
L
G
K
E
G
I
T
R
E
E
M
V
A
A
C
K
M
A
N
A
E
K
F
I
K
T
L
P
N
G
-
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
A
--
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
-
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
Q
G
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
G-----------------------------------------ER
I
G
------------------------------------
K
D
A
L
S
R
L
K
Q
E
L
-------------------------
E
E
N
-
N
A
Q
KTN
L
F
E
I
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
AGN
P
A
DFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
--------------
C
S
F
L
M
T
F
F
M
G
I
A
--
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIG
F
F
D
--------------
S
P-
Q
--------------------------------
N
A
S
G
K
-
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGK
N
VKSA
S
E
F
A
D
S
G
K
I
--
A
I
---------------------------------------------------------------
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
T-------------------
D
PPT
M
Q
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
K
I
S
K
-------
I
DSLSLA
G
E
K
K
K
L
Y
G
K
V
I
F
K
N
V
R
F
A
Y
P
E
R
------
P
E
I
E
I
L
K
G
L
S
F
S
V
E
P
G
Q
T
L
A
L
V
G
P
S
G
C
G
K
S
T
V
V
A
L
L
E
R
F
Y
D
T
L
G
G
E
I
F
I
D
G
S
E
I
K
T
L
N
---
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
--
L
F
-
D
C
S
I
A
E
N
I
I
Y
G
L
D
P
S
S
V
T
------
M
A
Q
V
E
E
A
A
R
L
A
-
N
I
H
----------
N
F
I
A
E
LPEGFE
T
R
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
--
E
G
R
T
C
I
V
I
A
H
R
L
N
T
V
M
N
-
A
D
C
I
A
V
V
S
N
G
T
I
I
E
K
G
T
H
T
Q
L
M
S
-
E
K
-------------------------
2
PsiBlast_PDB
68.17
32%
-148
- C2 -
-
3TUZ
1
METN_ECOLI
C:
[23-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
-----
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
--
V
T
E
L
L
S
L
V
-
G
L
G
----------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
-
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
D
Y
Q
---
24
PsiBlast_CBE
67.42
32%
-150
- C2 -
-
3TUI
1
METN_ECOLI
H:
[23-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
-----
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
--
V
T
E
L
L
S
L
V
-
G
L
G
----------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
-
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
D
Y
Q
---
5
PsiBlast_PDB
66.65
32%
-149
- C2 -
-
3TUJ
-
METN_ECOLI
C:
[0-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
-----
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
--
V
T
E
L
L
S
L
V
-
G
L
G
----------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
-
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
D
Y
Q
---
122
HHSearch
66.53
25%
-16
- C2 -
-
5KO2
-
MDR1A_MOUSE
A:
[385-1233]
-------
Q
G
N
L
E
F
K
N
I
H
F
S
Y
P
S
R
--
K
E
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
-----
D
-
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
----
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
--
F
-
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
-
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
Q
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
--
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
-
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
-----------------
L
V
M
T
Q
TD
V
P
P
A
S
F
W
R
-----
I
L
-----------------
K
L
---
N
------------------------------------
S
TE
W
P
Y
F
V
V
G
I
F
C
A
I
I
N
G
G
L
Q
P
A
F
S
V
I
F
S
K
V
V
G
V
F
T
N
G
G
P
P
E
T
-------------------------------------------------
Q
R
Q
N
S
N
L
F
S
L
L
F
L
I
L
G
I
I
S
F
I
T
F
F
L
Q
G
F
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
M
L
R
Q
D
--------
V
S
-----------
W
F
D
DPKNT
T
G
A
L
T
T
R
L
A
N
--
D
AAQ
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
-------------------------------
D
K
K
E
L
-------
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
V
V
S
L
TR
E
Q
K
F
E
T
M
Y
A
Q
S
L
Q
I
P
Y
R
N
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
C
F
R
F
G
A
Y
L
V
T
Q
QLMT
F
E
N
V
L
L
V
F
S
A
I
V
F
G
A
M
A
----------------------------------------------
V
G
Q
V
S
S
F
APD
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
E
---
K
---------------------------------------------
T
P
E
IDSYSTQ
G
------
L
K
P
N
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
T
R
------
P
S
I
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
P
M
A
G
S
V
F
L
D
G
K
E
I
K
Q
L
N
---
V
Q
W
L
R
A
Q
L
G
I
V
S
Q
E
P
I
--
L
F
-
D
C
S
I
A
E
N
I
A
Y
G
D
N
S
R
V
V
S
------
Y
E
E
I
V
R
A
A
K
E
A
-
N
I
H
----------
Q
F
I
D
S
LPDKYN
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
Q
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
R
--
E
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
-
A
D
L
I
V
V
I
Q
N
G
K
V
K
E
H
G
T
H
Q
Q
L
L
A
-
Q
K
G
I
Y
F
S
M
V
------------------
25
PsiBlast_CBE
66.16
32%
-141
- C2 -
-
3TUI
1
METN_ECOLI
G:
[24-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
-----
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
--
V
T
E
L
L
S
L
V
-
G
L
G
----------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
-
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
D
Y
Q
---
21
PsiBlast_CBE
66.10
32%
-147
- C2 -
-
3TUZ
1
METN_ECOLI
H:
[23-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
-----
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
--
V
T
E
L
L
S
L
V
-
G
L
G
----------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
-
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
D
Y
Q
---
1
PsiBlast_PDB
66.02
32%
-141
- C2 -
-
3TUI
1
METN_ECOLI
C:
[23-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
-----
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
--
V
T
E
L
L
S
L
V
-
G
L
G
----------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
-
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
D
Y
Q
---
22
PsiBlast_CBE
65.87
32%
-143
- C2 -
-
3TUZ
1
METN_ECOLI
G:
[24-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
-----
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
--
V
T
E
L
L
S
L
V
-
G
L
G
----------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
-
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
D
Y
Q
---
26
PsiBlast_CBE
65.01
32%
-139
- C2 -
-
3TUI
1
METN_ECOLI
D:
[24-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
-----
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
--
V
T
E
L
L
S
L
V
-
G
L
G
----------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
-
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
D
Y
Q
---
23
PsiBlast_CBE
64.90
32%
-143
- C2 -
-
3TUZ
1
METN_ECOLI
D:
[24-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
-----
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
--
V
T
E
L
L
S
L
V
-
G
L
G
----------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
-
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
D
Y
Q
---
43
PsiBlast_CBE
64.48
31%
-120
- C2 -
-
5X40
2
CBIO_RHOCB
B:
[14-255]
-------
T
P
I
L
A
A
E
A
L
T
Y
A
F
P
G
G
----
V
K
A
L
D
D
L
S
L
A
V
P
K
G
E
S
L
A
I
L
G
P
N
G
A
G
K
S
T
L
L
L
H
L
N
G
T
L
-------
R
P
Q
S
G
R
V
L
L
G
G
T
A
T
G
H
S
R
K
D
L
T
G
-
W
R
R
R
V
G
L
V
L
Q
D
A
D
D
Q
L
F
A
T
-
T
V
F
E
D
V
S
-
F
G
P
L
N
L
G
--
L
S
E
A
E
A
R
A
R
V
E
E
A
L
A
A
L
S
I
S
D
L
R
---
D
R
P
T
H
M
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
R
P
E
V
L
L
L
D
Q
P
T
A
G
L
D
L
A
G
T
E
Q
L
L
T
L
L
R
G
L
R
A
-
A
G
M
T
L
V
F
S
T
H
D
V
E
L
A
A
A
L
A
D
R
V
A
L
F
R
T
G
R
V
L
A
E
G
A
A
E
A
V
L
---
S
D
R
A
T
-----------------
L
---------
A
---------
K
V
-----------------
A
L
---
R
------------------------------------
P
-----------------------------------
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
64.12
31%
-122
- C2 -
-
3FVQ
2
FBPC_NEIG1
B:
[5-230]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
I
G
H
L
S
K
S
F
---------
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
-
K
N
T
N
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
--
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
-
N
G
K
G
R
T
A
Q
E
R
Q
R
I
E
-
A
M
L
E
L
T
-
G
I
S
----------
E
----------
L
A
G
-
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
-
Q
P
-------------------------
108
PsiBlast_CBE
63.61
31%
-123
- C2 -
-
3FVQ
2
FBPC_NEIG1
A:
[5-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
I
G
H
L
S
K
S
F
---------
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
-
K
N
T
N
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
--
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
-
N
G
K
G
R
T
A
Q
E
R
Q
R
I
E
-
A
M
L
E
L
T
-
G
I
S
----------
E
----------
L
A
G
-
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
-
Q
P
-------------------------
146
Fugue
63.38
28%
-113
- C2 -
-
3TUZ
1
METN_ECOLI
H:
[23-362]
--------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
-
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
-
T
L
I
R
C
V
N
L
L
E
R
P
T
E
-----
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
-
A
R
R
Q
I
G
M
I
F
Q
H
F
--
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
-
N
--
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
---
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
-----------------
Q
---------
K
---------
F
I
QSTLHLDIPEDYQERLQ
A
E
---
P
------------------------------------
F
-----------------------------------
T
D
C
-
V
P
M
-------------------------------------------------
L
R
------------------------------------
L
E
F
-----------
T
--------
G
Q
-----------
S
V
D
--------------
A
PL
L
--------------------------------
S
E
T
A
R
-
R
--------------------------------------------------------
F
-----------
N
---------------
V
----------------------------------------------------------------
N
--------------
N
----------------------------------------------
N
I
-----------------------
I
---
S
---------------------------------------------
A
Q
M
-------
D
------
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
62.76
31%
-115
- C2 -
-
5X40
2
CBIO_RHOCB
A:
[14-255]
-------
T
P
I
L
A
A
E
A
L
T
Y
A
F
P
G
G
----
V
K
A
L
D
D
L
S
L
A
V
P
K
G
E
S
L
A
I
L
G
P
N
G
A
G
K
S
T
L
L
L
H
L
N
G
T
L
-------
R
P
Q
S
G
R
V
L
L
G
G
T
A
T
G
H
S
R
K
D
L
T
G
-
W
R
R
R
V
G
L
V
L
Q
D
A
D
D
Q
L
F
A
T
-
T
V
F
E
D
V
S
-
F
G
P
L
N
L
G
--
L
S
E
A
E
A
R
A
R
V
E
E
A
L
A
A
L
S
I
S
D
L
R
---
D
R
P
T
H
M
L
S
G
G
Q
K
R
R
V
A
I
A
G
A
V
A
M
R
P
E
V
L
L
L
D
Q
P
T
A
G
L
D
L
A
G
T
E
Q
L
L
T
L
L
R
G
L
R
A
-
A
G
M
T
L
V
F
S
T
H
D
V
E
L
A
A
A
L
A
D
R
V
A
L
F
R
T
G
R
V
L
A
E
G
A
A
E
A
V
L
---
S
D
R
A
T
-----------------
L
---------
A
---------
K
V
-----------------
A
L
---
R
------------------------------------
P
-----------------------------------
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.40
32%
-141
- C2 -
-
3DHW
-
METN_ECOLI
C:
[1-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
-----
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
-
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
--
V
T
E
L
L
S
L
V
-
G
L
G
----------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
-
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
D
Y
Q
---
142
HHSearch
62.01
31%
-124
- C2 -
-
3FVQ
2
FBPC_NEIG1
B:
[3-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
H
I
G
H
L
S
K
S
F
Q
N
---------
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
T
-
N
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
G
V
--
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
N
G
K
G
R
--
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
-
G
I
S
----------
E
-----------
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
-
Q
P
A
D
L
D
A
A
-------------------
20
PsiBlast_PDB
61.65
32%
-136
- C2 -
-
1Z47
-
?
A:
[31-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
L
P
P
Q
-----
K
R
N
V
G
L
V
F
Q
N
-
Y
A
-
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
R
E
K
R
V
P
K
D
E
M
D
A
R
---
V
R
E
L
L
R
F
-
M
R
L
----------
E
----------
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
-
K
P
-------------------------
101
PsiBlast_CBE
34.41
31%
-
- C2 -
-
3B5Y
2
MSBA_SALTY
B:
[355-572]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
---
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
-
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
----------
D
----------
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
--
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
-----------------------
100
PsiBlast_CBE
34.41
31%
-
- C2 -
-
3B5Y
2
MSBA_SALTY
C:
[355-572]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
---
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
-
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
----------
D
----------
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
--
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
-----------------------
102
PsiBlast_CBE
34.40
31%
-
- C2 -
-
3B5Y
2
MSBA_SALTY
A:
[355-572]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
---
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
-
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
----------
D
----------
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
--
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
-----------------------
99
PsiBlast_CBE
34.40
31%
-
- C2 -
-
3B5Y
2
MSBA_SALTY
D:
[355-572]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
---
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
-
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
----------
D
----------
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
--
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
-----------------------
98
PsiBlast_CBE
34.39
31%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
A:
[355-572]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
---
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
-
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
----------
D
----------
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
--
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
-----------------------
97
PsiBlast_CBE
34.39
31%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
B:
[355-572]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
---
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
-
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
----------
D
----------
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
--
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
-----------------------
96
PsiBlast_CBE
34.39
31%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
C:
[355-572]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
---
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
-
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
----------
D
----------
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
--
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
-----------------------
95
PsiBlast_CBE
34.39
31%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
D:
[355-572]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
---
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
-
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
----------
D
----------
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
--
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
-----------------------