@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNV2: (2017-11-18 )
MFQQEISQLNLQQLKAGEKRWVGSLLGSSAALLLKEIATQHSSLLVLVARNNQHVAQLESELEFYGVKPTIFPDWEILPYDRLSPHQDIVSERLAILSNMPQKGVLLISASTLAQRVAPYSWVLGEHFDIKVGQKFDLEQQKLRLVQAGYHLVDTVYDHGEFAVRGSIMDIFASGQESPIRIDLFDDEIDSLKFFDPETQRTTTTLKSFTVLPAKEFPLKEGRSVFRDRYSEFFPTANPKKNPIYQDVLDGIASPGIEFYLPLFFDKEQMQTQSMFTKYLPKNCIVITTNDIDTDLTNFWKEVMRRYEDRRHNMDQPILAPEELFISPNHLLSALNQFPRMLVSAETIEEKAGALNLKTEQPPKLPVDPKKEKPFSAVKKYIDEANHPVLLVAESAGRRESLKDALRSSLGEIPNVENFEQFQISQFAIAITNAPLDRGLLLTDQLTVISENQLYEHRVVQRRRKRQQEVSEEFLIRSLTELSIGAPVVHIDYGVGRYAGLITLAIEGQDYEFLQLDYAEDAKVYVPVTNLHLISRYSGGDPDSAPLHKIGTDAWSKAKRKALEQIHDVAAELLHIQARRQSKPGFAFELDQSLYMQFASGFAYEETLDQANAIEATLYDMQQAKPMDRLVCGDVGFGKTEVAMRAAFVAVQNGKQVAVLVPTTLLAQQHYESFKDRFADWPVRIEVLSRFGSNKTHLKNIEDLANGKVDIVVGTHKLLQENVQFKDLGLMVVDEEHRFGVRDKERIKALRADVDMLTLTATPIPRTLNMAFSGMRDLSIIATPPARRLAVKTFVQEHTDASIKEAILRELLRGGQVYFLHNEVETIERAAENIRVLVPEARVAVAHGQMRERELEQVMQQFYHKEYNVLVCSTIIETGIDVPNANTILIERADKLGLAQLHQLRGRVGRSHHQAYAYLLVPSIKHLKGDAEKRLDAIQRASTLGAGFMLATEDLEIRGAGELLGEQQSGSMQAIGYSLYMEMLEKETKAIQQGKTPNFDAPLSLTAEINLHIPALIPDDYLGDVHQRLLFYKRISNTDTQEKLDNIRMELIDRFGIPPQSVKHLFSVHQIRLKAEHLGIKKIDINTQGGNIEFSPDTPVQAISIIQLIQKNPTYYRMEGGQRLKVMVQLEEYEKRIQFINDLLQKLMSELHA
Atome Classification :
(20 SA)
.........10.........20........30........40........50........60.-.....-..70-........80........90........100-.--.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......-220...-....230.......240.--......250.......260..----.....270.......280.......290.......300.......310.......320-........330.......340......---.350.......360.......370.......380..---.....390.......400.......410.......420.---.---.....430.......440------------..-.-....450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600..-.....610.......620.......630.......640.......650.------------......660........670.......680-----........690.......700..--.....710........---------.720----------.......730.....----------..740-----.---.-----.----..---...---750----.....---....760.......770....---..-.780--...--..---.-.790......-.--800.........810---........820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920----........930...---------....940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......-1110......1120......1130......1140......1150
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
F
Q
Q
E
I
S
Q
L
N
-
L
Q
Q
L
KAG
E
K
R
W
V
G
S
L
L
G
S
S
A
A
L
L
L
K
E
I
A
TQHS
S
L
L
V
L
V
ARNN
Q
H
V
A
Q
L
E
S
E
L
-
E
FYGV-KPTI-FPDWEILPYDRLS
P
H
Q
D
I
V
S
E
R
L
A
I
L
SNMP--Q--K
G
V
L
L
I
S
A
S
T
L
A
Q
RVAP
Y
S
W
VLG
E
H
F
D
I
KVGQKFD
L
E
Q
Q
K
L
R
L
V
Q
A
G
Y
H
L
V
D
T
V
YDHG
E
F
A
VR
G
S
I
M
D
I
FASGQES
P
I
R
I
D
LFDDEIDSLKFFDPETQ
R
T
T
T
T
L
K
S
F
T
VLPAKEFP
L
-
K
E
G
R
S
V
-
F
R
D
R
Y
S
E
FFPTANPKKN
P
--
I
Y
Q
D
V
L
D
G
I
ASPG
I
E
F
Y
L
P
L
F
----F
D
K
E
Q
M
Q
T
Q
S
M
F
T
K
YLPK
N
C
I
V
I
TTNDID
T
D
L
T
N
F
W
K
E
V
M
R
R
Y
E
D
R
RHNMDQPIL
A
P
--
E
E
LFI
S
P
N
H
L
L
S
A
L
N
Q
F
P
R
M
L
V
S
A
E
T
I
---
E
E
KAGALNLKTEQPPKLPVDPKKEK
P
F
S
A
V
K
K
Y
I
D
E---ANH
P
V
L
L
V
AESAG
R
R
E
S
L
K
D
A
L
R
S
S
LGEIPNV
E
N
F
E
Q
F
Q
---
I
---
S
Q
F
A
I
A
I
TNAPLDRG
L
L
L
------------
T
D
-
Q
-
L
T
V
ISEN
Q
L
Y
E
H
R
V
V
Q
R
R
R
K
R
Q
Q
E
V
S
E
E
F
L
I
R
S
L
T
E
LSIGA
P
V
V
H
I
DYGVGR
Y
A
G
L
I
T
L
A
I
EGQD
Y
E
F
L
Q
L
DYAED
A
K
V
Y
V
P
VT
N
L
H
L
I
S
RYSGGDPDSA
P
L
H
KIG
T
D
A
W
S
K
A
K
R
K
A
L
E
Q
I
H
D
V
A
A
E
L
L
H
I
Q
A
R
RQSKPG
F
A
F
EL
D
Q
S
L
Y
M
Q
F
A
SGF
A
Y
-
E
E
T
LDQAN
A
I
E
A
T
L
Y
D
M
Q
QAKP
M
D
R
L
VCGDVGF
G
K
T
E
V
A
M
R
A
A
F
V
A
VQN------------G
K
Q
V
A
V
L
V-
P
T
T
L
L
A
Q
Q
H
Y
E
S
F
K
D
R
FADW------
P
V
R
I
E
V
L
S
R
FGSNKT
H
L
K
N
I
E
D
L--ANG
K
V
D
--
I
V
VG
T
H
K
L
---------
L
Q
EN----------VQFKD
L
G
L
M
V
VDEEH----------RFGV------R---
D
-----
K
----
E
R
---
I
K
A
---
L
------RADV
D
---
M
L
T
L
TATPIP
R
T
L
N
M
A
FSGMR---
D
L
-
S
I
I
A--TPP--
A
R
---
R
-
L
A
V
K
T
F
V
Q
EH-T--D--
A
S
I
K
E
A
I
L
R
E
-
L
---LRGG
Q
V
Y
F
L
H
N
E
V
E
T
I
E
R
A
A
EN
I
R
V
LVPE
A
R
V
A
VAH
G
Q
M
R
E
R
E
L
E
Q
V
M
Q
Q
F
Y
HKEY
N
V
L
V
C
S
T
I
I
ETGIDVPNA
N
T
I
L
I
ERADKL
G
L
A
Q
L
H
Q
L
R
G
R
VGRSHH
Q
A
Y
A
Y
L
L
V-----P
S
I
K
H
LKG
D
A
E
K
R
L
---------
D
A
I
Q
R
A
S
TLGA
G
F
M
L
A
TE
D
L
E
I
R
G
A
G
E
LLGEQQSG
S
M
Q
A
I
G
Y
S
L
Y
M
E
M
L
E
K
E
T
K
A
I
QQGKTPNFDAP
L
S
L
T
A
E
I
N
L
H
IPALIP
D
D
Y
L
G
D
V
H
Q
R
L
L
F
Y
K
RISNT
D
T
Q
E
K
L
D
N
I
R
M
E
L
I
D
RFGI
P
P
Q
S
V
K
H
L
F
S
V
H
Q
I
R
L
K
A
E
HL
G
I
K
K
I
D
I
NTQGG
N
I
E
FSPDTP
V
Q
A
I
S
I
I
Q
L
I
-QKNP
T
Y
Y
R
MEGG
Q
R
L
K
V
M
V
Q
L
E
E
Y
E
K
R
I
Q
F
I
N
D
L
L
Q
K
L
M
S
E
LHA
1
PsiBlast_PDB
61.05
50%
25
- C1 -
-
2EYQ
3
MFD_ECOLI
A:
[14-1145]
--------------
V
K
A
G
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
-
M
V
M
N
-
L
A
D
W
E
T
L
P
Y
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
TM
Q
--
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
-
F
R
S
Q
W
R
D
T
F
E
V
---
K
R
D
P
EH
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
----
F
S
E
P
---
L
P
P
L
F
S
-
Y
F
P
A
N
T
L
L
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
P
M
R
P
L
L
P
P
--
Q
S
L
W
L
R
V
D
E
L
F
S
E
L
K
N
W
P
R
V
Q
L
K
T
E
H
L
---
P
T
K
A
A
N
A
N
L
G
F
Q
K
L
P
D
L
A
V
Q
A
Q
Q
K
A
P
L
D
A
L
R
K
F
L
E
T
---
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
--------
G
E
L
-----
L
A
R
I
K
---
I
---
A
P
Q
R
I
M
R
L
D
E
A
S
D
R
G
R
Y
L
M
I
GAAE
H
G
F
V
D
T
V
R
-
N
-
L
A
L
I
C
E
S
D
L
L
G
E
R
V
A
R
R
R
Q
D
S
R
R
T
I
N
P
D
T
L
I
R
N
L
A
E
L
H
I
G
Q
P
V
V
H
L
E
H
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
E
E
N
A
P
L
H
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
N
------------
H
K
Q
V
A
V
L
V
-
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
W
------
P
V
R
I
E
M
I
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R
F
R
S
A
K
E
Q
T
Q
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L
A
E
V
--
A
E
G
K
I
D
--
I
L
I
G
T
H
K
L
---------
L
Q
S
D
----------
V
K
F
K
D
L
G
L
L
I
V
D
E
E
H
----------
R
F
G
V
------
R
---
H
-----
K
----
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R
---
I
K
A
---
M
------
R
A
N
V
D
---
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
S
G
M
R
---
D
L
-
S
I
I
A
--
T
P
P
--
A
R
---
R
-
L
A
V
K
T
F
V
R
E
Y
-
D
--
S
--
M
V
V
R
E
A
I
L
R
E
-
I
---
L
R
G
G
Q
V
Y
Y
L
Y
N
D
V
E
N
I
Q
K
A
A
E
R
L
A
E
L
V
P
E
A
R
I
A
I
G
H
G
Q
M
R
E
R
E
L
E
R
V
M
N
D
F
H
H
Q
R
F
N
V
L
V
C
T
T
I
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
E
R
A
D
H
F
G
L
A
Q
L
H
Q
L
R
G
R
V
G
R
S
H
H
Q
A
Y
A
W
L
L
T
-----
P
H
P
K
A
M
T
T
D
A
Q
K
R
L
---------
E
A
I
A
S
L
E
D
L
G
A
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
I
G
F
S
L
Y
M
E
L
L
E
N
A
V
D
A
L
K
A
G
R
E
P
S
L
E
D
L
T
S
Q
Q
T
E
V
E
L
R
M
P
S
L
L
P
D
D
F
I
P
D
V
N
T
R
L
S
F
Y
K
R
I
A
S
A
K
T
E
N
E
L
E
E
I
K
V
E
L
I
D
R
F
G
L
L
P
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
G
I
R
K
L
E
G
N
E
K
G
G
V
I
E
F
A
E
K
N
H
V
N
P
A
W
L
I
G
L
L
-
Q
K
Q
P
Q
H
Y
R
L
D
G
P
T
R
L
K
F
I
Q
D
L
S
E
R
K
T
R
I
E
W
V
R
Q
F
M
R
E
L
------
21
PsiBlast_CBE
60.68
50%
23
- C1 -
-
2EYQ
3
MFD_ECOLI
B:
[14-1145]
--------------
V
K
A
G
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
-
M
V
M
N
-
L
A
D
W
E
T
L
P
Y
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
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---
K
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---
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---
P
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F
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--------
G
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L
-----
L
A
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---
I
---
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-
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G
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R
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N
------------
H
K
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-
P
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L
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L
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----------
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F
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----
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------
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---------
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A
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A
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A
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L
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S
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K
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R
I
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W
V
R
Q
F
M
R
E
L
------
40
Fugue
60.39
50%
22
- C1 -
-
2EYQ
3
MFD_ECOLI
A:
[5-1150]
---
P
E
Q
Y
R
Y
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----
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A
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A
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N
------------
H
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L
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-----
P
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P
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A
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A
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---------
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A
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A
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L
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A
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A
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A
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A
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L
L
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A
I
-
48
HHSearch
59.51
50%
16
- C1 -
-
2EYQ
3
MFD_ECOLI
A:
[5-1148]
-----
P
E
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Y
R
Y
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L
P
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--------
S
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G
E
L
L
-----
A
R
I
K
I
A
P
Q
R
I
M
R
---
L
DEA
S
D
R
G
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
------------
T
V
R
N
-
L
A
L
I
C
E
S
D
L
L
G
E
R
V
A
R
R
R
Q
D
S
R
R
T
I
N
P
D
T
L
I
R
N
L
A
E
L
H
I
G
Q
P
V
V
H
L
E
H
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
E
E
N
A
P
L
H
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
N
------------
H
K
Q
V
A
V
L
V
-
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
W
------
P
V
R
I
E
M
I
S
R
F
R
S
A
K
E
Q
T
Q
I
L
A
E
V
--
A
E
G
K
I
D
--
I
L
I
G
T
H
K
L
---------
L
Q
S
D
----------
V
K
F
K
D
L
G
L
L
I
V
D
E
E
H
----------
R
F
G
V
------
R
---
H
-----
K
----
E
R
---
I
K
A
---
M
------
R
A
N
V
D
---
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
S
G
M
R
---
D
L
-
S
I
I
A
--
T
P
P
--
A
R
---
R
-
L
A
V
K
T
F
V
R
E
Y
-
D
--
S
--
M
V
V
R
E
A
I
L
R
E
-
I
---
L
R
G
G
Q
V
Y
Y
L
Y
N
D
V
E
N
I
Q
K
A
A
E
R
L
A
E
L
V
P
E
A
R
I
A
I
G
H
G
Q
M
R
E
R
E
L
E
R
V
M
N
D
F
H
H
Q
R
F
N
V
L
V
C
T
T
I
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
E
R
A
D
H
F
G
L
A
Q
L
H
Q
L
R
G
R
V
G
R
S
H
H
Q
A
Y
A
W
L
L
T
-----
P
H
P
K
A
M
T
T
D
A
Q
K
R
L
---------
E
A
I
A
S
L
E
D
L
G
A
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
I
G
F
S
L
Y
M
E
L
L
E
N
A
V
D
A
L
K
A
G
R
E
P
S
L
E
D
L
T
S
Q
Q
T
E
V
E
L
R
M
P
S
L
L
P
D
D
F
I
P
D
V
N
T
R
L
S
F
Y
K
R
I
A
S
A
K
T
E
N
E
L
E
E
I
K
V
E
L
I
D
R
F
G
L
L
P
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
G
I
R
K
L
E
G
N
E
K
G
G
V
I
E
F
A
E
K
N
H
V
N
P
A
W
L
I
G
L
L
Q
K
Q
P
Q
H
Y
R
L
D
-
G
P
T
R
L
K
F
I
Q
D
L
S
E
R
K
T
R
I
E
W
V
R
Q
F
M
R
E
L
E
E
N
---
41
Fugue
44.02
35%
0
- C1 -
-
3HJH
-
MFD_ECOLI
A:
[5-450]
-------
Y
R
Y
-
T
L
P
V
K
A
G
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
-
S
Q
F
T
D
-
Q
M
V
M
N
L
A
D
W
E
T
L
P
Y
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
--
T
MQ
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
-
F
R
S
Q
W
R
D
T
F
E
-
V
K
R
D
P
E
H
--
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
----
F
S
E
---
P
L
P
P
L
F
-
S
Y
F
P
A
N
T
L
L
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
P
M
R
P
L
L
P
P
--
Q
S
L
W
L
R
V
D
E
L
F
S
E
L
K
N
W
P
R
V
Q
L
K
T
E
H
L
---
P
T
K
A
A
N
A
N
L
G
F
Q
K
L
P
D
L
A
V
Q
A
Q
Q
K
A
P
L
D
A
L
R
K
F
L
E
T
---
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
I
M
R
L
D
E
A
S
---
D
---
R
G
R
Y
L
M
I
--
G
A
A
E
H
G
F
V
D
------------
T
V
R
N
-
L
A
L
I
C
E
S
D
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
43.99
35%
10
- C1 -
-
3HJH
-
MFD_ECOLI
A:
[11-450]
--------------
V
K
A
G
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
-
M
V
M
N
-
L
A
D
W
E
T
L
P
Y
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
TM
Q
--
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
-
F
R
S
Q
W
R
D
T
F
E
V
---
K
R
D
P
EH
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
----
F
S
E
P
---
L
P
P
L
F
S
-
Y
F
P
A
N
T
L
L
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
P
M
R
P
L
L
P
P
--
Q
S
L
W
L
R
V
D
E
L
F
S
E
L
K
N
W
P
R
V
Q
L
K
T
E
H
L
---
P
T
K
A
A
N
A
N
L
G
F
Q
K
L
P
D
L
A
V
Q
A
Q
Q
K
A
P
L
D
A
L
R
K
F
L
E
T
---
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
--------
A
L
G
E
L
-----
L
A
R
I
K
---
I
---
A
P
Q
R
I
M
R
L
D
E
A
S
D
R
G
R
Y
L
M
I
G
AAE
H
G
F
V
DT
V
R
-
N
-
L
A
L
I
C
E
S
D
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
39.00
39%
8
- C1 -
-
2B2N
2
MFD_ECOLI
A:
[26-332]
-----------------------------
A
C
A
T
L
V
A
E
I
A
E
R
H
A
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
-
M
V
M
N
-
L
A
D
W
E
T
L
P
Y
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
TM
Q
--
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
-
F
R
S
Q
W
R
D
T
F
E
V
---
K
R
D
P
EH
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
----
F
S
E
P
---
L
P
P
L
F
S
-
Y
F
P
A
N
T
L
L
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
P
M
R
P
L
L
P
P
--
Q
S
L
W
L
R
V
D
E
L
F
S
E
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
38.73
33%
-9
- C1 -
-
3HJH
-
MFD_ECOLI
A:
[12-450]
---------------
K
A
G
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
-
S
Q
F
T
D
Q
M
V
M
N
-
L
A
D
W
E
T
L
P
Y
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
--
T
MQ
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
-
D
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
R
D
P
E
H
I
--
Y
Q
Q
V
S
-
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
F
SEP
L
P
P
L
F
--------
S
Y
F
P
A
N
T
L
L
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
P
M
R
P
L
L
P
P
QS
L
W
L
R
V
D
E
L
F
S
E
--
L
K
N
W
P
---
R
V
Q
L
K
T
EHL
P
T
K
A
A
N
A
N
L
G
F
Q
K
L
P
D
L
-
A
V
Q
A
Q
Q
K
--
A
P
L
D
A
L
R
K
F
L
E
T
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
-----
A
R
I
K
I
A
P
Q
R
I
M
R
LDE
A
---
S
D
R
G
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
------------
T
V
R
N
-
L
A
L
I
C
E
S
D
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
38.70
39%
6
- C1 -
-
2B2N
2
MFD_ECOLI
B:
[26-332]
-----------------------------
A
C
A
T
L
V
A
E
I
A
E
R
H
A
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
-
M
V
M
N
-
L
A
D
W
E
T
L
P
Y
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
TM
Q
--
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
-
F
R
S
Q
W
R
D
T
F
E
V
---
K
R
D
P
EH
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
----
F
S
E
P
---
L
P
P
L
F
S
-
Y
F
P
A
N
T
L
L
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
P
M
R
P
L
L
P
P
--
Q
S
L
W
L
R
V
D
E
L
F
S
E
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
33.61
27%
-173
* C2 *
-
2QSR
-
?
A:
[1011-1103]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
L
I
L
Q
I
D
A
Y
L
P
D
T
Y
I
S
D
Q
R
H
K
I
E
I
Y
K
K
I
R
Q
I
D
N
R
V
N
Y
E
E
L
Q
E
E
L
I
D
R
F
G
E
Y
P
D
V
V
A
Y
L
L
E
I
G
L
V
K
S
Y
L
D
K
V
F
V
Q
R
V
E
R
K
D
N
K
I
T
I
Q
F
E
K
V
T
--------------------------------------------------------
6
PsiBlast_PDB
33.54
31%
-108
- C1 -
-
4NL8
-
?
A:
[236-466]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
A
G
I
T
G
S
G
K
T
E
V
Y
L
S
V
L
E
N
V
L
A
Q
------------
G
R
Q
A
L
V
M
V
-
P
E
I
G
L
T
P
Q
T
I
A
R
F
R
Q
R
F
N
---------
A
P
V
E
V
L
H
S
G
L
N
D
S
E
R
L
S
A
W
L
K
A
--
K
N
G
E
A
A
--
I
V
I
G
T
R
S
S
---------
L
--
F
----------
T
P
F
K
D
L
G
V
I
V
I
D
E
E
H
DSSYKQQEGW
R
Y
H
A
------
R
---
D
-----
L
----
A
V
---
W
R
A
---
H
------
S
E
Q
I
P
---
I
I
L
G
S
A
T
P
A
L
E
T
L
H
N
V
R
Q
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
33.28
31%
-114
- C1 -
-
4NL4
1
?
H:
[236-414]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
A
G
I
T
G
S
G
K
T
E
V
Y
L
S
V
L
E
N
V
L
A
Q
------------
G
R
Q
A
L
V
M
V
-
P
E
I
G
L
T
P
Q
T
I
A
R
F
R
Q
R
F
N
---------
A
P
V
E
V
L
H
S
G
L
N
D
S
E
R
L
S
A
W
L
K
A
--
K
N
G
E
A
A
--
I
V
I
G
T
R
S
S
---------
L
--
F
----------
T
P
F
K
D
L
G
V
I
V
I
D
E
E
H
DSSYKQQEGW
R
Y
H
A
------
R
---
D
-----
L
----
A
V
---
W
R
A
---
H
------
S
E
Q
I
P
---
I
I
L
G
S
A
T
P
A
L
E
T
L
H
N
V
R
Q
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
31.84
18%
-19
- C1 -
-
1OYW
-
RECQ_ECOLI
A:
[14-344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
V
L
Q
E
T
F
G
Y
Q
Q
F
R
P
G
Q
E
E
I
I
D
T
V
L
S
G
------
R
D
C
L
V
V
M
P
T
G
G
G
K
S
L
C
Y
Q
I
P
A
L
L
L
---------------
N
G
L
T
V
V
V
S
-
P
L
I
S
L
M
K
D
Q
V
D
Q
L
Q
A
N
G
----------
V
A
A
A
C
L
N
S
T
Q
T
R
E
Q
Q
L
E
V
M
T
G
C
--
R
T
G
Q
I
R
--
L
L
Y
I
A
P
E
R
---------
L
M
L
D
N
F
L
E
H
-----
L
A
H
W
N
P
V
L
L
A
V
D
E
A
H
----------
C
I
S
Q
------
W
---
G
HDF--
R
P
E
Y
-
A
A
---
L
G
Q
L
R
Q
R
------
F
P
T
L
P
---
F
M
A
L
T
A
T
A
D
D
T
T
R
Q
D
I
V
R
L
L
G
LN-
D
P
-
L
-
I
Q
--
I
S
S
--
F
D
---
R
-
P
N
I
R
Y
M
L
M
E
K
-
F
--
K
P
L
D
Q
L
M
R
Y
V
Q
E
------
Q
R
G
K
S
G
I
I
Y
C
N
S
R
A
K
V
E
D
T
A
A
R
L
Q
S
K
--
G
I
S
A
A
A
Y
H
A
G
L
E
N
N
V
R
A
D
V
Q
E
K
F
Q
R
D
D
L
Q
I
V
V
A
T
V
A
F
G
M
G
I
N
K
P
N
V
R
F
V
V
H
F
D
I
P
-
R
N
I
E
S
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
A
E
A
M
L
F
Y
-----
D
P
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
31.48
18%
-11
- C1 -
-
4W7S
6
PRP28_YEAST
A:
[65-419]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
L
R
F
P
S
P
T
P
I
Q
R
I
T
I
P
N
V
C
N
M
---
K
Q
Y
R
D
F
L
G
V
A
S
T
G
S
G
K
T
L
A
F
V
I
P
I
L
I
K
M
S
R
S
PPRP
P
S
L
K
I
I
D
G
P
K
A
L
I
L
A
-
P
T
R
E
L
V
Q
Q
I
Q
K
E
T
Q
K
V
T
K
I
W
S
K
E
SNY
D
C
K
V
I
S
I
V
G
G
H
S
L
E
E
I
---
S
F
S
L
---
S
E
G
C
D
--
I
L
V
A
T
P
G
R
---------
L
I
D
S
L
E
N
HL-----
L
V
M
K
Q
V
E
T
L
V
L
D
E
A
D
----------
K
M
I
D
------
L
---
G
F
E
D
Q
V
T
----
N
I
---
L
T
K
---
V
D
I
N
ADS
A
V
N
R
Q
---
T
L
M
F
T
A
T
M
T
P
V
I
E
K
I
A
A
G
Y
M
Q
---
K
P
-
V
Y
A
T
I
G
V
E
T
--
G
S
---
E
-
P
L
I
Q
Q
V
V
E
Y
A
D
N
--
D
--
E
D
K
F
K
K
L
K
P
I
-
V
A
--
K
Y
D
P
P
I
I
I
F
I
N
Y
K
Q
T
A
D
W
L
A
E
K
F
Q
K
E
T
-
N
M
K
V
T
I
L
H
G
S
K
S
Q
E
Q
R
E
H
S
L
Q
L
F
R
T
N
K
V
Q
I
M
I
A
T
N
V
A
A
R
G
L
D
I
P
N
V
S
L
V
V
N
F
Q
I
S
-
K
K
M
D
D
Y
I
H
R
I
G
R
T
G
R
A
A
N
E
G
T
A
V
S
F
V
-----
S
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
31.34
18%
-18
- C1 -
-
5LB8
-
RECQ5_HUMAN
D:
[4-444]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
R
R
V
R
S
T
L
K
K
V
F
G
F
-
D
S
---
F
K
T
P
L
Q
E
S
A
T
M
A
V
V
K
G
N
K
D
V
F
V
C
M
P
T
G
A
G
K
S
L
C
Y
Q
L
P
A
L
L
A
----------------
K
G
I
T
I
V
V
S
P
L
I
A
L
I
Q
D
Q
V
D
H
L
L
T
L
----------
K
V
R
V
S
S
L
N
S
K
L
S
A
Q
E
R
K
E
L
L
A
D
L
--
E
R
E
K
P
Q
TK
I
L
Y
I
T
P
E
M
AASSSFQPT
L
N
S
L
----------
V
S
R
H
L
L
S
Y
L
V
V
D
E
A
H
----------
C
V
S
Q
WGHDFR
P
---
D
-----
Y
----
L
R
---
L
G
A
---
L
------
R
S
R
L
G
HAP
C
V
A
L
T
A
T
A
T
P
Q
V
Q
E
D
V
F
A
A
L
H
LKK
P
V
-
A
I
F
K
--
T
P
C
--
F
R
---
A
N
L
F
Y
D
V
Q
F
K
E
L
-
I
--
S
--
D
P
Y
G
N
--
L
K
D
-
F
---
C
L
K
A
C
G
I
V
Y
C
R
T
R
E
A
C
E
Q
L
A
I
E
L
S
C
R
G
V
N
A
K
A
Y
--
H
A
G
L
K
A
S
E
R
T
L
V
Q
N
D
W
M
E
E
K
V
P
V
I
V
A
T
I
----
S
F
D
K
A
N
V
R
F
V
A
H
W
N
I
A
K
-
S
M
A
G
Y
Y
Q
E
S
G
R
A
G
R
D
G
K
P
S
W
C
R
L
Y
Y
SRNDR
D
Q
V
S
F
L
I
R
K
E
V
A
K
L
QEKRGNKAS
D
K
A
T
I
M
A
F
D
A
L
V
T
F
C
E
E
L
G
C
R
H
A
A
I
A
K
Y
F
G
D
A
L
P
A
C
A
K
G
C
D
H
C
Q
N
P
T
A
V
R
R
R
L
E
A
L
E
R
S
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
68
HHSearch
31.24
17%
-1
- C1 -
-
2DB3
2
VASA1_DROME
A:
[70-407]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
N
K
S
G
Y
K
-
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
------
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
DP
H
E
L
E
L
G----
R
P
Q
V
V
I
V
S
-
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
S
------
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
---
E
C
I
---
T
R
G
C
H
--
V
V
I
A
T
P
G
R
---------
L
L
D
F
V
D
R
TF-----
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
----------
R
M
L
D
------
M
---
G
F
S
E
D
M
R
----
R
I
---
M
T
H
---
V
TM----
R
P
E
H
Q
---
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
---
N
Y
-
V
F
V
A
--
I
G
I
VG
G
A
---
C
-
S
D
V
K
Q
T
I
Y
E
V
-
N
--
K
--
Y
A
K
R
S
K
L
I
E
I
L
S
---
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
--
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
-
S
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
-----
D
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
30.84
16%
-21
- C1 -
-
2V1X
1
RECQ1_HUMAN
A:
[27-378]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
W
S
G
K
V
K
D
I
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
A
G
------
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
---
S
------------
D
G
F
T
L
V
I
C
-
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
----------
G
I
S
A
T
M
L
N
A
S
S
S
K
E
H
V
K
W
V
H
A
E
M
V
N
K
N
S
E
L
K
--
L
I
Y
V
T
P
E
K
---------
I
A
K
S
K
M
F
M
S
R
L
E
K
A
Y
E
A
R
R
F
T
R
I
A
V
D
E
V
H
----------
C
C
S
Q
------
W
GHD
F
R
P
D
--
Y
----
K
A
L
G
I
L
K
R
---
Q
------
F
P
N
A
S
---
L
I
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
---
I
E
K
C
F
T
F
--
T
A
S
--
F
N
---
R
-
P
N
L
Y
Y
E
V
R
Q
K
-
P
SN
T
--
E
D
F
I
E
D
I
V
K
L
-
I
N
G
R
Y
K
G
Q
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
--
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
-
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
-----
G
F
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
30.71
17%
-4
- C1 -
-
5SUP
2
SUB2_YEAST
A:
[13-357]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
P
E
L
S
R
A
I
I
D
C
G
F
E
-
H
P
S
E
V
Q
Q
H
T
I
P
Q
S
I
H
G
------
T
D
V
L
C
Q
A
K
S
G
L
G
K
T
A
V
F
V
L
S
T
L
Q
Q
L
D
P
VPG---------
E
V
A
V
V
V
I
C
-
N
A
R
E
L
A
Y
Q
I
R
N
E
Y
L
R
F
S
K
Y
M
P-----
D
V
K
T
A
V
F
Y
G
G
T
P
I
S
K
D
A
E
L
L
K
N
---
K
D
T
A
P
H
--
I
V
V
A
T
P
G
R
---------
L
K
A
L
V
R
E
KY-----
I
D
L
S
H
V
K
N
F
V
I
D
E
C
D
----------
K
V
L
E
------
E
L
D
-
M
-----
R
R
D
V
Q
E
I
---
F
R
A
---
T
------
P
R
D
K
Q
---
V
M
M
F
S
A
T
L
S
Q
E
I
R
P
I
C
R
R
F
L
Q
---
N
P
-
L
E
I
F
--
V
D
D
--
E
A
KLT
L
-
H
G
L
Q
Q
Y
Y
I
K
L
-
E
--
E
--
R
E
K
N
R
K
L
A
Q
L
-
L
D
D
-
L
E
F
N
Q
V
I
I
F
V
K
S
T
T
R
A
N
E
L
T
K
L
L
N
A
S
--
N
F
P
A
I
T
V
H
G
H
M
K
Q
E
E
R
I
A
R
Y
K
A
F
K
D
F
E
K
R
I
C
V
S
T
D
V
F
G
R
G
I
D
I
E
R
I
N
L
A
I
N
Y
D
L
T
-
N
E
A
D
Q
Y
L
H
R
V
G
R
A
G
R
F
G
T
K
G
L
A
I
S
F
V
-----
S
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
30.53
16%
-19
* C1 *
-
4U7D
-
RECQ1_HUMAN
C:
[28-375]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
S
G
K
V
K
D
I
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
A
G
------
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
---
S
------------
D
G
F
T
L
V
I
C
-
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
----------
G
I
S
A
T
M
L
N
A
S
S
S
K
E
H
V
K
W
V
H
A
E
M
VN
K
N
S
E
L
K
--
L
I
Y
V
T
P
E
K
---------
I
A
K
S
KMFMSRLEKA
Y
E
A
R
R
F
T
R
I
A
V
D
E
V
H
----------
C
C
S
Q
WGH---
D
---
F
-----
R
PDY-
K
A
LGI
L
K
R
---
Q
------
F
P
N
A
S
---
L
I
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
C
---
I
E
K
C
F
T
F
--
T
A
S
--
F
N
---
R
-
P
N
L
Y
Y
E
V
R
Q
K
-
P
SN
T
--
E
D
F
I
E
D
I
V
K
L
-
I
NGR
Y
K
G
Q
S
G
I
I
Y
C
F
S
Q
K
D
S
E
Q
V
T
V
S
L
Q
N
L
--
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
-
K
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
-----
G
F
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
30.42
17%
-8
- C1 -
-
5SUQ
3
SUB2_YEAST
A:
[69-413]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
P
E
L
S
R
A
I
I
D
C
G
F
E
-
H
P
S
E
V
Q
Q
H
T
I
P
Q
S
I
H
G
------
T
D
V
L
C
Q
A
K
S
G
L
G
K
T
A
V
F
V
L
S
T
L
Q
Q
L
D
P
VPG---------
E
V
A
V
V
V
I
C
-
N
A
R
E
L
A
Y
Q
I
R
N
E
Y
L
R
F
S
K
Y
M
P-----
D
V
K
T
A
V
F
Y
G
G
T
P
I
S
K
D
A
E
L
L
K
N
---
K
D
T
A
P
H
--
I
V
V
A
T
P
G
R
---------
L
K
A
L
V
R
E
KY-----
I
D
L
S
H
V
K
N
F
V
I
D
E
C
D
----------
K
V
L
E
------
E
L
D
-
M
R
R
D
V
-
Q
----
E
I
---
F
R
A
---
T
------
P
R
D
K
Q
---
V
M
M
F
S
A
T
L
S
Q
E
I
R
P
I
C
R
R
F
L
Q
---
N
P
-
L
E
I
F
--
V
------------
G
L
Q
Q
Y
Y
I
K
L
-
E
--
E
--
R
E
K
N
R
K
L
A
Q
L
-
L
D
D
-
L
E
F
N
Q
V
I
I
F
V
K
S
T
T
R
A
N
E
L
T
K
L
L
N
A
S
--
N
F
P
A
I
T
V
H
G
H
M
K
Q
E
E
R
I
A
R
Y
K
A
F
K
D
F
E
K
R
I
C
V
S
T
D
V
F
G
R
G
I
D
I
E
R
I
N
L
A
I
N
Y
D
L
T
-
N
E
A
D
Q
Y
L
H
R
V
G
R
A
G
R
F
G
T
K
G
L
A
I
S
F
V
-----
S
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------