@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNY9: (2017-11-18 )
MQIKTPDIGVDKANVAEILVKVGDRVEVDDSIVVLESDKATVEVPSTSAGVVKSILINQGDDVTEGVALIEIEAEGAAQAAPEPTPAPAAEKPGAPAPAQQTQASAQPAAATSAATVEVTVPDIGVEKALVGEILVKVGDQIDVEQSIVVVESDKATVEVPSTVAGVVKAIHLQAGQQVSQGVLLATIEAEGQAPAAAPAAKAEAAPAPQAAAPKAAAPVATQSAPAASTSGTDKLTKEQEAENAKVYAGPAVRKLARELGVILSQVKTSGEHGRVVKEDIFAYVKSRLTAPQAAPVAQATAAPAGLPSLPDFTAFGGGEVKPMTRLQQVSVPQLSLNNYIPQVTQFDLADITELEAWRGELKDGFKKQGVSLTILAFIAKAVAHLLKEEPYFAGHLADDQKSVLLRNEIHMGIAVATPDGLTVPVLRNPDQKSIKQIAVELGELSKKARDKKLTPKDLQGANFTITSLGSIGGTAFTPLVNWPQVAILGISPATMQPVWNGKDFDPRLMLPLSLSYDHRVINGADAARFTNKLTKLLKDIRTLLI
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310-........320.......330....---...-340.......350.......360..--...--..370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500..-......510.......520.......530.......540....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQIKTPDIGV
D
K
A
N
V
A
E
I
L
V
KVG
D
R
V
EVD
D
S
I
V
V
L
ESDK
A
T
V
EVPST
S
A
G
V
V
K
S
I
L
INQGDDVTE
G
V
A
L
I
E
I
EAEGAAQAAPEPTPAPAAEKPGAPAP
A
Q
Q
TQASAQPAAAT
S
A
A
T
V
E
V
TVPDIG
V
E
K
A
L
V
G
E
I
L
V
KVGDQIDV
E
Q
S
I
V
V
V
ESDK
A
T
V
EV
P
S
T
V
A
G
V
V
K
A
I
H
L
QAGQQVSQ
G
V
L
L
A
T
I
EAEGQAPAAAPAAKAEAAPAPQAAAPKAAAPVATQSAPAASTSGTDKL
T
K
E
Q
EAEN
A
K
V
YA
G
P
A
V
R
K
L
A
R
E
L
G
V
I
L
S
Q
V
KTSGEHGR
V
V
K
E
D
I
F
A
Y
V
K
S
RLTAPQAAPVAQATAAPAGLPSLP--DFTAFGGGEV
K
P
M
T
R
L
QQVSVP
Q
L
S
---
L
NN-YIPQVTQF
D
L
A
D
I
T
E
L
E
A
W
R
G
E
L
K
D
--
G
F
K
--KQGV
S
L
T
I
L
A
F
I
A
K
A
V
A
H
L
L
KEEPYFAGHLAD
D
Q
K
S
V
L
L
RNE
I
H
M
G
I
A
V
ATPDG
L
T
V
PVLRNP
D
Q
K
S
I
K
Q
I
A
V
E
L
G
E
L
S
K
K
ARDKKL
T
P
K
DLQGA
N
F
T
I
T
SLGSIGG
T
A
FTPLVNWP
Q
V
A
I
L
GISPATMQPVWN-GK-DFD
P
R
L
M
L
P
L
SLSYDHRVING
A
D
A
A
R
F
T
N
K
L
T
K
L
L
K
D
I
R
T
LLI
3
PsiBlast_PDB
100.00
58%
0
- C- -
-
1EAC
1
A:
[1-243]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
P
I
P
PV
D
F
A
K
Y
G
E
I
E
E
V
P
M
T
R
L
M
Q
I
G
A
T
N
L
H
R
S
W
L
N
---
V
P
H
V
T
Q
F
E
S
A
D
I
T
E
L
E
A
F
R
V
A
Q
K
A
--
V
A
K
--
K
A
G
V
K
L
T
V
L
P
L
L
L
K
A
C
A
Y
L
L
K
E
L
P
D
F
N
S
S
L
A
P
S
G
Q
A
L
I
R
K
K
Y
V
H
I
G
F
A
V
D
T
P
D
G
L
L
V
P
V
I
R
N
V
D
Q
K
S
L
L
Q
L
A
A
E
A
A
E
L
A
E
K
A
R
S
K
K
L
G
A
D
A
M
Q
G
A
C
F
T
I
S
S
L
G
H
I
G
G
T
A
F
T
P
I
V
N
A
P
E
V
A
I
L
G
V
S
K
A
S
M
Q
P
V
W
D
-
G
K
-
A
F
Q
P
R
L
M
L
P
L
S
L
S
Y
D
H
R
V
I
N
G
A
A
A
A
R
F
T
K
R
L
G
D
L
L
A
D
I
R
A
I
L
L
2
PsiBlast_PDB
100.00
58%
0
- C- -
-
1EAB
1
A:
[1-243]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
P
I
P
PV
D
F
A
K
Y
G
E
I
E
E
V
P
M
T
R
L
M
Q
I
G
A
T
N
L
H
R
S
W
L
N
---
V
P
H
V
T
Q
F
E
S
A
D
I
T
E
L
E
A
F
R
V
A
Q
K
A
--
V
A
K
--
K
A
G
V
K
L
T
V
L
P
L
L
L
K
A
C
A
Y
L
L
K
E
L
P
D
F
N
S
S
L
A
P
S
G
Q
A
L
I
R
K
K
Y
V
H
I
G
F
A
V
D
T
P
D
G
L
L
V
P
V
I
R
N
V
D
Q
K
S
L
L
Q
L
A
A
E
A
A
E
L
A
E
K
A
R
S
K
K
L
G
A
D
A
M
Q
G
A
C
F
T
I
S
S
L
G
H
I
G
G
T
A
F
T
P
I
V
N
A
P
E
V
A
I
L
G
V
S
K
A
S
M
Q
P
V
W
D
-
G
K
-
A
F
Q
P
R
L
M
L
P
L
S
L
S
Y
D
H
R
V
I
N
G
A
A
A
A
R
F
T
K
R
L
G
D
L
L
A
D
I
R
A
I
L
L
93
HHSearch
72.31
59%
-29
- C3 -
-
1DPD
-
ODP2_AZOVI
A:
[405-637]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
G
E
I
E
E
V
P
M
T
R
L
M
Q
I
G
A
T
N
L
H
---
R
S
W
L
N
V
P
H
V
T
Q
F
E
S
A
D
I
T
E
L
E
A
F
R
V
A
Q
K
A
--
V
A
E
--
K
A
G
V
K
L
T
V
L
P
L
L
L
K
A
C
A
Y
L
L
K
E
L
P
D
F
N
S
S
L
A
P
S
G
Q
A
L
I
R
K
K
Y
V
H
I
G
F
A
V
D
T
P
D
G
L
L
V
P
V
I
R
N
V
D
Q
K
S
L
L
Q
L
A
A
E
A
A
E
L
A
E
K
A
R
S
K
K
L
G
A
D
A
M
Q
G
A
C
F
T
I
A
S
L
G
H
I
G
G
T
A
F
T
P
I
V
N
A
P
E
V
A
I
L
G
V
S
K
A
S
M
Q
P
V
W
D
-
G
K
-
A
F
Q
P
R
L
M
L
P
L
S
L
S
Y
D
H
R
V
I
N
G
A
A
A
A
R
F
T
K
R
L
G
D
L
L
A
D
I
R
A
I
L
L
94
HHSearch
71.12
58%
-31
- C3 -
-
1DPB
-
ODP2_AZOVI
A:
[405-637]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
G
E
I
E
E
V
P
M
T
R
L
M
Q
I
G
A
T
N
L
H
---
R
S
W
L
N
V
P
H
V
T
Q
F
E
S
A
D
I
T
E
L
E
A
F
R
V
A
Q
K
A
--
V
A
E
--
K
A
G
V
K
L
T
V
L
P
L
L
L
K
A
C
A
Y
L
L
K
E
L
P
D
F
N
S
S
L
A
P
S
G
Q
A
L
I
R
K
K
Y
V
H
I
G
F
A
V
D
T
P
D
G
L
L
V
P
V
I
R
N
V
D
Q
K
S
L
L
Q
L
A
A
E
A
A
E
L
A
E
K
A
R
S
K
K
L
G
A
D
A
M
Q
G
A
C
F
T
I
S
S
L
G
H
I
G
G
T
A
F
T
P
I
V
N
A
P
E
V
A
I
L
G
V
S
K
A
S
M
Q
P
V
W
D
-
G
K
-
A
F
Q
P
R
L
M
L
P
L
S
L
S
Y
D
C
R
V
I
N
G
A
A
A
A
R
F
T
K
R
L
G
D
L
L
A
D
I
R
A
I
L
L
1
PsiBlast_PDB
69.75
58%
21
- C3 -
-
1EAA
-
ODP2_AZOVI
A:
[395-637]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
P
I
P
PV
D
F
A
K
Y
G
E
I
E
E
V
P
M
T
R
L
M
Q
I
G
A
T
N
L
H
R
S
W
L
N
---
V
P
H
V
T
Q
F
E
S
A
D
I
T
E
L
E
A
F
R
V
A
Q
K
A
--
V
A
K
--
K
A
G
V
K
L
T
V
L
P
L
L
L
K
A
C
A
Y
L
L
K
E
L
P
D
F
N
S
S
L
A
P
S
G
Q
A
L
I
R
K
K
Y
V
H
I
G
F
A
V
D
T
P
D
G
L
L
V
P
V
I
R
N
V
D
Q
K
S
L
L
Q
L
A
A
E
A
A
E
L
A
E
K
A
R
S
K
K
L
G
A
D
A
M
Q
G
A
C
F
T
I
S
S
L
G
H
I
G
G
T
A
F
T
P
I
V
N
A
P
E
V
A
I
L
G
V
S
K
A
S
M
Q
P
V
W
D
-
G
K
-
A
F
Q
P
R
L
M
L
P
L
S
L
S
Y
D
H
R
V
I
N
G
A
A
A
A
R
F
T
K
R
L
G
D
L
L
A
D
I
R
A
I
L
L
13
PsiBlast_PDB
69.39
41%
-144
- C3 -
-
1B5S
-
ODP2_GEOSE
A:
[221-425]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
V
T
L
M
D
E
A
D
V
T
K
L
V
A
H
R
K
K
F
K
A
--
I
A
A
--
E
K
G
I
K
L
T
F
L
P
Y
V
V
K
A
L
V
S
A
L
R
E
Y
P
V
L
N
T
S
I
D
D
E
T
E
E
I
I
Q
K
H
Y
Y
N
I
G
I
A
A
D
T
D
R
G
L
L
V
P
V
I
K
H
A
D
R
K
P
I
F
A
L
A
Q
E
I
N
E
L
A
E
K
A
R
D
G
K
L
T
P
G
E
M
K
G
A
S
C
T
I
T
N
I
G
S
A
G
G
Q
W
F
T
P
V
I
N
H
P
E
V
A
I
L
G
I
G
R
I
A
E
K
P
I
V
R
-
D
G
-
E
I
V
A
A
P
M
L
A
L
S
L
S
F
D
H
R
M
I
D
G
A
T
A
Q
K
A
L
N
H
I
K
R
L
L
S
D
P
E
L
L
L
M
97
HHSearch
69.38
50%
9
- C3 -
-
4N72
-
?
C:
[396-629]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
E
I
E
E
V
E
L
G
R
I
Q
K
I
S
G
A
N
L
S
---
R
N
W
V
M
I
P
H
V
T
H
F
D
K
T
D
I
T
E
L
E
A
F
R
K
Q
Q
N
E
--
E
A
A
KR
K
L
D
V
K
I
T
P
V
V
F
I
M
K
A
V
A
A
A
L
E
Q
M
P
R
F
N
S
S
L
S
E
D
G
Q
R
L
T
L
K
K
Y
I
N
I
G
V
A
V
D
T
P
N
G
L
V
V
P
V
F
K
D
V
N
K
K
G
I
I
E
L
S
R
E
L
M
T
I
S
K
K
A
R
D
G
K
L
T
A
G
E
M
Q
G
G
C
F
T
I
S
S
I
G
G
L
G
T
T
H
F
A
P
I
V
N
A
P
E
V
A
I
L
G
V
S
K
S
A
M
E
P
V
W
N
-
G
K
-
E
F
V
P
R
L
M
L
P
I
S
L
S
F
D
H
R
V
I
D
G
A
D
G
A
R
F
I
T
I
I
N
N
T
L
S
D
I
R
R
L
V
M
6
PsiBlast_PDB
69.26
58%
20
- C3 -
-
1EAF
-
A:
[1-243]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
P
I
P
PV
D
F
A
K
Y
G
E
I
E
E
V
P
M
T
R
L
M
Q
I
G
A
T
N
L
H
R
S
W
L
N
---
V
P
H
V
T
Q
F
E
S
A
D
I
T
E
L
E
A
F
R
V
A
Q
K
A
--
V
A
K
--
K
A
G
V
K
L
T
V
L
P
L
L
L
K
A
C
A
Y
L
L
K
E
L
P
D
F
N
S
S
L
A
P
S
G
Q
A
L
I
R
K
K
Y
V
H
I
G
F
A
V
D
T
P
D
G
L
L
V
P
V
I
R
N
V
D
Q
K
S
L
L
Q
L
A
A
E
A
A
E
L
A
E
K
A
R
S
K
K
L
G
A
D
A
M
Q
G
A
C
F
T
I
S
S
L
G
H
I
G
G
T
A
F
T
P
I
V
N
A
P
E
V
A
I
L
G
V
S
K
A
S
M
Q
P
V
W
D
-
G
K
-
A
F
Q
P
R
L
M
L
P
L
S
L
S
Y
D
H
R
V
I
N
G
A
A
A
A
R
F
T
K
R
L
G
D
L
L
A
D
I
R
A
I
L
L
4
PsiBlast_PDB
69.19
58%
20
- C3 -
-
1EAD
1
A:
[1-243]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
P
I
P
PV
D
F
A
K
Y
G
E
I
E
E
V
P
M
T
R
L
M
Q
I
G
A
T
N
L
H
R
S
W
L
N
---
V
P
H
V
T
Q
F
E
S
A
D
I
T
E
L
E
A
F
R
V
A
Q
K
A
--
V
A
K
--
K
A
G
V
K
L
T
V
L
P
L
L
L
K
A
C
A
Y
L
L
K
E
L
P
D
F
N
S
S
L
A
P
S
G
Q
A
L
I
R
K
K
Y
V
H
I
G
F
A
V
D
T
P
D
G
L
L
V
P
V
I
R
N
V
D
Q
K
S
L
L
Q
L
A
A
E
A
A
E
L
A
E
K
A
R
S
K
K
L
G
A
D
A
M
Q
G
A
C
F
T
I
S
S
L
G
H
I
G
G
T
A
F
T
P
I
V
N
A
P
E
V
A
I
L
G
V
S
K
A
S
M
Q
P
V
W
D
-
G
K
-
A
F
Q
P
R
L
M
L
P
L
S
L
S
Y
D
H
R
V
I
N
G
A
A
A
A
R
F
T
K
R
L
G
D
L
L
A
D
I
R
A
I
L
L
8
PsiBlast_PDB
69.16
57%
16
- C3 -
-
1DPC
-
ODP2_AZOVI
A:
[395-637]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
P
I
P
PV
D
F
A
K
Y
G
E
I
E
E
V
P
M
T
R
L
M
Q
I
G
A
T
N
L
H
R
S
W
L
N
---
V
P
H
V
T
Q
F
E
S
A
D
I
T
E
L
E
A
F
R
V
A
Q
K
A
--
V
A
E
--
K
A
G
V
K
L
T
V
L
P
L
L
L
K
A
C
A
Y
L
L
K
E
L
P
D
F
N
S
S
L
A
P
S
G
Q
A
L
I
R
K
K
Y
V
H
I
G
F
A
V
D
T
P
D
G
L
L
V
P
V
I
R
N
V
D
Q
K
S
L
L
Q
L
A
A
E
A
A
E
L
A
E
K
A
R
S
K
K
L
G
A
D
A
M
Q
G
A
C
F
T
I
S
S
L
G
H
I
G
G
T
A
F
T
P
I
V
N
A
P
E
V
A
I
L
G
V
S
K
A
S
M
Q
P
V
W
D
-
G
K
-
A
F
Q
P
R
L
M
L
P
L
S
L
S
Y
D
H
R
V
I
D
G
A
A
A
A
R
F
T
K
R
L
G
D
L
L
A
D
I
R
A
I
L
L
7
PsiBlast_PDB
69.13
57%
23
- C3 -
-
1DPD
-
ODP2_AZOVI
A:
[395-637]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
P
I
P
PV
D
F
A
K
Y
G
E
I
E
E
V
P
M
T
R
L
M
Q
I
G
A
T
N
L
H
R
S
W
L
N
---
V
P
H
V
T
Q
F
E
S
A
D
I
T
E
L
E
A
F
R
V
A
Q
K
A
--
V
A
E
--
K
A
G
V
K
L
T
V
L
P
L
L
L
K
A
C
A
Y
L
L
K
E
L
P
D
F
N
S
S
L
A
P
S
G
Q
A
L
I
R
K
K
Y
V
H
I
G
F
A
V
D
T
P
D
G
L
L
V
P
V
I
R
N
V
D
Q
K
S
L
L
Q
L
A
A
E
A
A
E
L
A
E
K
A
R
S
K
K
L
G
A
D
A
M
Q
G
A
C
F
T
I
A
S
L
G
H
I
G
G
T
A
F
T
P
I
V
N
A
P
E
V
A
I
L
G
V
S
K
A
S
M
Q
P
V
W
D
-
G
K
-
A
F
Q
P
R
L
M
L
P
L
S
L
S
Y
D
H
R
V
I
N
G
A
A
A
A
R
F
T
K
R
L
G
D
L
L
A
D
I
R
A
I
L
L
98
HHSearch
68.83
50%
14
- C3 -
-
4N72
-
?
B:
[396-627]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
E
I
E
E
V
E
L
G
R
I
Q
K
I
S
G
A
N
L
S
---
R
N
W
V
M
I
P
H
V
T
H
F
D
K
T
D
I
T
E
L
E
A
F
R
K
Q
Q
N
E
--
E
A
A
KR
K
L
D
V
K
I
T
P
V
V
F
I
M
K
A
V
A
A
A
L
E
Q
M
P
R
F
N
S
S
L
S
E
D
G
Q
R
L
T
L
K
K
Y
I
N
I
G
V
A
V
D
T
P
N
G
L
V
V
P
V
F
K
D
V
N
K
K
G
I
I
E
L
S
R
E
L
M
T
I
S
K
K
A
R
D
G
K
L
T
A
G
E
M
Q
G
G
C
F
T
I
S
S
I
G
G
L
G
T
T
H
F
A
P
I
V
N
A
P
E
V
A
I
L
G
V
S
K
S
A
M
E
P
V
W
N
-
G
K
-
E
F
V
P
R
L
M
L
P
I
S
L
S
F
D
H
R
V
I
D
G
A
D
G
A
R
F
I
T
I
I
N
N
T
L
S
D
I
R
R
L
--
5
PsiBlast_PDB
68.58
58%
18
- C3 -
-
1EAE
1
A:
[1-243]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
P
I
P
P
V
D
F
A
K
Y
G
E
I
E
E
V
P
M
T
R
L
M
Q
I
G
A
T
N
L
H
R
S
W
L
N
---
V
P
H
V
T
Q
F
E
S
A
D
I
T
E
L
E
A
F
R
V
A
Q
K
A
--
V
A
K
--
K
A
G
V
K
L
T
V
L
P
L
L
L
K
A
C
A
Y
L
L
K
E
L
P
D
F
N
S
S
L
A
P
S
G
Q
A
L
I
R
K
K
Y
V
H
I
G
F
A
V
D
T
P
D
G
L
L
V
P
V
I
R
N
V
D
Q
K
S
L
L
Q
L
A
A
E
A
A
E
L
A
E
K
A
R
S
K
K
L
G
A
D
A
M
Q
G
A
C
F
T
I
S
S
L
G
H
I
G
G
T
A
F
T
P
I
V
N
A
P
E
V
A
I
L
G
V
S
K
A
S
M
Q
P
V
W
D
-
G
K
-
A
F
Q
P
R
L
M
L
P
L
S
L
S
Y
D
H
R
V
I
N
G
A
A
A
A
R
F
T
K
R
L
G
D
L
L
A
D
I
R
A
I
L
L
9
PsiBlast_PDB
68.36
57%
17
- C3 -
-
1DPB
-
ODP2_AZOVI
A:
[395-637]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
P
I
P
PV
D
F
A
K
Y
G
E
I
E
E
V
P
M
T
R
L
M
Q
I
G
A
T
N
L
H
R
S
W
L
N
---
V
P
H
V
T
Q
F
E
S
A
D
I
T
E
L
E
A
F
R
V
A
Q
K
A
--
V
A
E
--
K
A
G
V
K
L
T
V
L
P
L
L
L
K
A
C
A
Y
L
L
K
E
L
P
D
F
N
S
S
L
A
P
S
G
Q
A
L
I
R
K
K
Y
V
H
I
G
F
A
V
D
T
P
D
G
L
L
V
P
V
I
R
N
V
D
Q
K
S
L
L
Q
L
A
A
E
A
A
E
L
A
E
K
A
R
S
K
K
L
G
A
D
A
M
Q
G
A
C
F
T
I
S
S
L
G
H
I
G
G
T
A
F
T
P
I
V
N
A
P
E
V
A
I
L
G
V
S
K
A
S
M
Q
P
V
W
D
-
G
K
-
A
F
Q
P
R
L
M
L
P
L
S
L
S
Y
D
C
R
V
I
N
G
A
A
A
A
R
F
T
K
R
L
G
D
L
L
A
D
I
R
A
I
L
L
92
HHSearch
67.26
31%
0
- C- -
-
2II5
-
ODB2_BOVIN
D:
[29-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
D
R
T
E
P
V
K
G
F
H
K
A
M
V
K
T
M
S
---
A
A
L
-
K
I
P
H
F
G
Y
C
D
E
V
D
L
T
E
L
V
K
L
R
E
E
L
K
P
--
I
A
F
--
A
R
G
I
K
L
S
F
M
P
F
F
L
K
A
A
S
L
G
L
L
Q
F
P
I
L
N
A
S
V
D
E
N
C
Q
N
I
T
Y
K
A
S
H
N
I
G
I
A
M
D
T
E
Q
G
L
I
V
P
N
V
K
N
V
Q
I
R
S
I
F
E
I
A
T
E
L
N
R
L
Q
K
L
G
S
A
G
Q
L
S
T
N
D
L
I
G
G
T
F
T
L
S
N
I
G
S
I
G
G
T
Y
A
K
P
V
I
L
P
P
E
V
A
I
G
A
L
G
T
I
K
A
L
P
R
F
N
E
K
G
-
E
V
C
K
A
Q
I
M
N
V
S
W
S
A
D
H
R
I
I
D
G
A
T
V
S
R
F
S
N
L
W
K
S
Y
L
E
N
P
A
F
M
L
L
31
PsiBlast_CBE
67.26
31%
0
- C- -
-
2II4
19
ODB2_BOVIN
H:
[29-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
D
R
T
E
P
V
K
G
F
H
K
A
M
V
K
T
M
S
---
A
A
L
-
K
I
P
H
F
G
Y
C
D
E
V
D
L
T
E
L
V
K
L
R
E
E
L
K
P
--
I
A
F
--
A
R
G
I
K
L
S
F
M
P
F
F
L
K
A
A
S
L
G
L
L
Q
F
P
I
L
N
A
S
V
D
E
N
C
Q
N
I
T
Y
K
A
S
H
N
I
G
I
A
M
D
T
E
Q
G
L
I
V
P
N
V
K
N
V
Q
I
R
S
I
F
E
I
A
T
E
L
N
R
L
Q
K
L
G
S
A
G
Q
L
S
T
N
D
L
I
G
G
T
F
T
L
S
N
I
G
S
I
G
G
T
Y
A
K
P
V
I
L
P
P
E
V
A
I
G
A
L
G
T
I
K
A
L
P
R
F
N
-
E
K
G
E
V
C
K
A
Q
I
M
N
V
S
W
S
A
D
H
R
I
I
D
G
A
T
V
S
R
F
S
N
L
W
K
S
Y
L
E
N
P
A
F
M
L
L
23
PsiBlast_CBE
67.26
31%
0
- C- -
-
2II5
28
ODB2_BOVIN
H:
[29-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
D
R
T
E
P
V
K
G
F
H
K
A
M
V
K
T
M
S
---
A
A
L
-
K
I
P
H
F
G
Y
C
D
E
V
D
L
T
E
L
V
K
L
R
E
E
L
K
P
--
I
A
F
--
A
R
G
I
K
L
S
F
M
P
F
F
L
K
A
A
S
L
G
L
L
Q
F
P
I
L
N
A
S
V
D
E
N
C
Q
N
I
T
Y
K
A
S
H
N
I
G
I
A
M
D
T
E
Q
G
L
I
V
P
N
V
K
N
V
Q
I
R
S
I
F
E
I
A
T
E
L
N
R
L
Q
K
L
G
S
A
G
Q
L
S
T
N
D
L
I
G
G
T
F
T
L
S
N
I
G
S
I
G
G
T
Y
A
K
P
V
I
L
P
P
E
V
A
I
G
A
L
G
T
I
K
A
L
P
R
F
N
-
E
K
G
E
V
C
K
A
Q
I
M
N
V
S
W
S
A
D
H
R
I
I
D
G
A
T
V
S
R
F
S
N
L
W
K
S
Y
L
E
N
P
A
F
M
L
L
19
PsiBlast_PDB
67.26
31%
0
- C- -
-
2IHW
-
ODB2_BOVIN
A:
[29-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
D
R
T
E
P
V
K
G
F
H
K
A
M
V
K
T
M
S
---
A
A
L
-
K
I
P
H
F
G
Y
C
D
E
V
D
L
T
E
L
V
K
L
R
E
E
L
K
P
--
I
A
F
--
A
R
G
I
K
L
S
F
M
P
F
F
L
K
A
A
S
L
G
L
L
Q
F
P
I
L
N
A
S
V
D
E
N
C
Q
N
I
T
Y
K
A
S
H
N
I
G
I
A
M
D
T
E
Q
G
L
I
V
P
N
V
K
N
V
Q
I
R
S
I
F
E
I
A
T
E
L
N
R
L
Q
K
L
G
S
A
G
Q
L
S
T
N
D
L
I
G
G
T
F
T
L
S
N
I
G
S
I
G
G
T
Y
A
K
P
V
I
L
P
P
E
V
A
I
G
A
L
G
T
I
K
A
L
P
R
F
N
-
E
K
G
E
V
C
K
A
Q
I
M
N
V
S
W
S
A
D
H
R
I
I
D
G
A
T
V
S
R
F
S
N
L
W
K
S
Y
L
E
N
P
A
F
M
L
L
10
PsiBlast_PDB
66.39
49%
16
- C3 -
-
4N72
-
?
A:
[392-628]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
S
K
F
G
E
I
E
E
V
E
L
G
R
I
Q
K
I
S
G
A
N
L
S
---
R
N
W
V
M
I
P
H
V
T
H
F
D
K
T
D
I
T
E
L
E
A
F
R
K
Q
Q
N
E
E
A
A
K
R
--
K
L
D
V
K
I
T
P
V
V
F
I
M
K
A
V
A
A
A
L
E
Q
M
P
R
F
N
S
S
L
S
E
D
G
Q
R
L
T
L
K
K
Y
I
N
I
G
V
A
V
D
T
P
N
G
L
V
V
P
V
F
K
D
V
N
K
K
G
I
I
E
L
S
R
E
L
M
T
I
S
K
K
A
R
D
G
K
L
T
A
G
E
M
Q
G
G
C
F
T
I
S
S
I
G
G
L
G
T
T
H
F
A
P
I
V
N
A
P
E
V
A
I
L
G
V
S
K
S
A
M
E
P
V
W
N
-
G
K
-
E
F
V
P
R
L
M
L
P
I
S
L
S
F
D
H
R
V
I
D
G
A
D
G
A
R
F
I
T
I
I
N
N
T
L
S
D
I
R
R
L
V
-
91
HHSearch
65.01
31%
-98
- C3 -
-
2II3
-
ODB2_BOVIN
B:
[29-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
D
R
T
E
P
V
K
G
F
H
K
A
M
V
K
T
M
S
---
A
A
L
-
K
I
P
H
F
G
Y
C
D
E
V
D
L
T
E
L
V
K
L
R
E
E
L
K
P
--
I
A
F
--
A
R
G
I
K
L
S
F
M
P
F
F
L
K
A
A
S
L
G
L
L
Q
F
P
I
L
N
A
S
V
D
E
N
C
Q
N
I
T
Y
K
A
S
H
N
I
G
I
A
M
D
T
E
Q
G
L
I
V
P
N
V
K
N
V
Q
I
R
S
I
F
E
I
A
T
E
L
N
R
L
Q
K
L
G
S
A
G
Q
L
S
T
N
D
L
I
G
G
T
F
T
L
S
N
I
G
S
I
G
G
T
Y
A
K
P
V
I
L
P
P
E
V
A
I
G
A
L
G
T
I
K
A
L
P
R
F
N
E
K
G
-
E
V
C
K
A
Q
I
M
N
V
S
W
S
A
D
H
R
I
I
D
G
A
T
V
S
R
F
S
N
L
W
K
S
Y
L
E
N
P
A
F
M
L
L