@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNZ8: (2017-11-18 )
MSPTTAANQAKKLIKVPEMRRIKHIHFVGIGGAGMCGIAEVLANQGYKISGSDINASKTTQQLEENGIKVYIGHEAENIKNANVLVVSTAIDPENPEVKAAIEQRIPIVRRAEMLGELMRYRHGIAVAGTHGKTTTTSLLTTMLAEENLDPTYVIGGLLNSTGVNAALGESRFIVAEADESDASFLYLQPMAAIVTNIDADHMDTYEGSFDKLKDTFVQFLHNLPFYGLAVVCGDDANIREILPRVGRPVITYGFNEDNDIRAIDVERDGMRSHFTVLRKGREPLRLTINQPGLHNVLNALAAIGVATDEGVSDEAISRALKGFSGVGRRFQVQGEFELGEGNVKLVDDYGHHPKEVEATIKAARQSHPDRRLVMLFQPHRYSRTRDCFDDFIEVLSQVDQLLLLEVYPAGEKPIVGADSRTLARSIRLRGQVEPILIDPVEGNLQNIMQNVLQPNDLLLTQGAGNVGAISVELAQHHLYVK
Atome Classification :
(20 SA)
.........10........20........30........40........50.....-...60........70........80-.........90........100.......110.......120.....-....130.......140.......150.......160.......---------.170.......180....-------...190.......200.......210.......220.......230.......240...-....250.......-260.......270.......280.......290.......300.......310.......320.......330...----.--.-----.-----.-----340---.........350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSPT
T
A
A
N
Q
A
K
K
L
IKVPEMR
R
I
K
H
I
H
F
V
GIGG
A
G
M
C
G
I
A
E
V
L
ANQG
Y
K
ISGSDIN
A
-
S
K
T
T
Q
Q
L
E
EN
G
I
K
V
Y
IGHEAENIK--NA
N
V
L
V
V
S
TAIDPEN
P
E
V
K
A
A
I
E
QRI
P
I
V
R
R
A
E
M
L
G
E
L
M
R
--
Y
RH
G
I
-
A
V
AGTHGK
T
T
T
T
S
L
L
T
T
M
L
A
EENLD
P
T
Y
V
I
GGLLN-STGVNAAL---------GE
S
R
F
I
V
A
EADESDA
S
F
L
-------
Y
LQ
P
M
A
A
I
V
TNIDADHMDTYEG
S
F
D
K
L
K
D
T
F
V
Q
F
L
HNLPFY
G
L
A
V
V
CGDDA
N
I
R
E
I
L
P
R-VGR
P
V
I
T
Y
GFNEDN-
D
I
R
A
I
D
VERD
G
M
R
S
H
F
T
V
L
R
KGRE
P
L
R
L
T
INQP
G
L
H
N
V
L
N
A
L
A
A
IGVATDEGV
S
D
E
A
I
S
R
A
L
K
G
F
SGVG
R
R
F
Q
V
Q
G
----
E
--
F
-----E-----L-----G-----EG
N
V
K
L
VDDYGH
H
P
K
E
V
E
A
T
I
K
A
A
R
QSHPD
R
R
L
V
M
L
FQPHRYS
R
T
R
D
C
F
D
D
F
I
E
V
L
S
Q
V
D
Q
L
L
L
L
E
VYPAGEKPIVGAD
S
R
T
L
A
R
S
I
RLRGQVE
P
I
L
IDPVEG
N
L
Q
N
I
M
Q
N
VLQPN
D
L
L
L
TQGAGN
V
G
A
I
S
V
E
L
A
Q
H
H
LYVK
5
PsiBlast_PDB
89.70
56%
-105
- C1 -
-
1P3D
2
MURC_HAEIN
A:
[12-471]
---------------
I
P
E
M
R
R
V
Q
Q
I
H
F
I
G
I
G
G
A
G
M
S
G
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
-
G
V
V
T
Q
R
L
A
Q
A
G
A
K
I
Y
I
G
H
A
E
E
H
I
E
--
G
A
S
V
V
V
V
S
S
A
I
K
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
I
Q
R
A
Q
M
L
A
E
I
M
R
--
F
R
H
G
I
-
A
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
K
L
D
P
T
F
V
N
G
G
L
V
K
-
S
A
G
K
N
A
H
L
---------
G
A
S
R
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
E
G
D
F
E
K
M
K
A
T
Y
V
K
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
A
D
D
P
V
L
M
E
L
V
P
K
-
V
G
R
Q
V
I
T
Y
G
F
S
E
Q
A
-
D
Y
R
I
E
D
Y
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
N
N
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
----
E
--
F
-----
I
-----
R
-----
P
-----
N
G
K
V
R
L
V
D
D
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
D
D
F
V
Q
V
L
S
Q
V
D
A
L
I
M
L
D
V
Y
A
A
G
E
A
P
I
V
G
A
D
S
K
S
L
C
R
S
I
R
N
L
G
K
V
D
P
I
L
V
S
D
T
S
-
Q
L
G
D
V
L
D
Q
I
I
Q
D
G
D
L
I
L
A
Q
G
A
G
S
V
S
K
I
S
R
G
L
A
E
------
4
PsiBlast_PDB
89.49
56%
-110
- C1 -
-
1P31
1
MURC_HAEIN
A:
[12-471]
---------------
I
P
E
M
R
R
V
Q
Q
I
H
F
I
G
I
G
G
A
G
M
S
G
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
-
G
V
V
T
Q
R
L
A
Q
A
G
A
K
I
Y
I
G
H
A
E
E
H
I
E
--
G
A
S
V
V
V
V
S
S
A
I
K
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
I
Q
R
A
Q
M
L
A
E
I
M
R
--
F
R
H
G
I
-
A
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
K
L
D
P
T
F
V
N
G
G
L
V
K
-
S
A
G
K
N
A
H
L
---------
G
A
S
R
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
E
G
D
F
E
K
M
K
A
T
Y
V
K
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
A
D
D
P
V
L
M
E
L
V
P
K
-
V
G
R
Q
V
I
T
Y
G
F
S
E
Q
A
-
D
Y
R
I
E
D
Y
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
N
N
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
----
E
--
F
-----
I
-----
R
-----
P
-----
N
G
K
V
R
L
V
D
D
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
D
D
F
V
Q
V
L
S
Q
V
D
A
L
I
M
L
D
V
Y
A
A
G
E
A
P
I
V
G
A
D
S
K
S
L
C
R
S
I
R
N
L
G
K
V
D
P
I
L
V
S
D
T
S
-
Q
L
G
D
V
L
D
Q
I
I
Q
D
G
D
L
I
L
A
Q
G
A
G
S
V
S
K
I
S
R
G
L
A
E
------
21
PsiBlast_CBE
88.98
58%
-113
- C1 -
-
1GQY
1
MURC_HAEIN
B:
[12-471]
---------------
I
P
E
M
R
R
V
Q
Q
I
H
F
I
G
I
G
G
A
G
M
S
G
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
-
G
V
V
T
Q
R
L
A
Q
A
G
A
K
I
Y
I
G
H
A
E
E
H
I
E
--
G
A
S
V
V
V
V
S
S
A
I
K
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
I
Q
R
A
Q
M
L
A
E
I
M
R
--
F
R
H
G
I
-
A
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
K
L
D
P
T
F
V
N
G
G
L
V
K
-
S
A
G
K
N
A
H
L
---------
G
A
S
R
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
E
G
D
F
E
K
M
K
A
T
Y
V
K
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
A
D
D
P
V
L
M
E
L
V
P
K
-
V
G
R
Q
V
I
T
Y
G
F
S
E
Q
A
-
D
Y
R
I
E
D
Y
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
N
N
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
----
E
--
F
-----
I
-----
R
-----
P
-----
N
G
K
V
R
L
V
D
D
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
D
D
F
V
Q
V
L
S
Q
V
D
A
L
I
M
L
D
V
Y
A
A
G
E
A
P
I
V
G
A
D
S
K
S
L
C
R
S
I
R
N
L
G
K
V
D
P
I
L
V
S
D
T
S
-
Q
L
G
D
V
L
D
Q
I
I
Q
D
G
D
L
I
L
A
Q
G
A
G
S
V
S
K
I
S
R
G
L
A
E
------
1
PsiBlast_PDB
88.75
58%
-115
* C1 *
-
1GQY
1
MURC_HAEIN
A:
[12-471]
---------------
I
P
E
M
R
R
V
Q
Q
I
H
F
I
G
I
G
G
A
G
M
S
G
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
-
G
V
V
T
Q
R
L
A
Q
A
G
A
K
I
Y
I
G
H
A
E
E
H
I
E
--
G
A
S
V
V
V
V
S
S
A
I
K
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
I
Q
R
A
Q
M
L
A
E
I
M
R
--
F
R
H
G
I
-
A
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
K
L
D
P
T
F
V
N
G
G
L
V
K
-
S
A
G
K
N
A
H
L
---------
G
A
S
R
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
-------
D
F
E
K
M
K
A
T
Y
V
K
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
A
D
D
P
V
L
M
E
L
V
P
K
-
V
G
R
Q
V
I
T
Y
G
F
S
E
Q
A
-
D
Y
R
I
E
D
Y
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
N
N
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
----
E
--
F
-----
I
-----
R
-----
P
-----
N
G
K
V
R
L
V
D
D
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
D
D
F
V
Q
V
L
S
Q
V
D
A
L
I
M
L
D
V
Y
A
A
G
E
A
P
I
V
G
A
D
S
K
S
L
C
R
S
I
R
N
L
G
K
V
D
P
I
L
V
S
D
T
S
-
Q
L
G
D
V
L
D
Q
I
I
Q
D
G
D
L
I
L
A
Q
G
A
G
S
V
S
K
I
S
R
G
L
A
E
------
2
PsiBlast_PDB
87.98
60%
-69
- C1 -
-
4HV4
2
MURC_YERPE
A:
[22-483]
---------------------
V
R
H
I
H
F
V
G
I
G
G
A
G
M
G
G
I
A
E
V
L
A
N
E
G
Y
Q
I
S
G
S
D
L
A
P
-
N
S
V
T
Q
H
L
T
A
L
G
A
Q
I
Y
F
H
H
R
P
E
N
V
L
--
D
A
S
V
V
V
V
S
T
A
I
S
A
D
N
P
E
I
V
A
A
R
E
A
R
I
P
V
I
R
R
A
E
M
L
A
E
L
M
R
--
Y
R
H
G
I
-
A
V
A
G
T
H
G
K
T
T
T
T
A
M
L
S
S
I
Y
A
E
A
G
L
D
P
T
F
V
N
G
G
L
V
K
-
A
A
G
T
H
A
R
L
---------
G
S
S
R
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
I
V
T
N
I
E
A
D
H
M
D
T
Y
Q
G
D
F
E
N
L
K
Q
T
F
I
N
F
L
H
N
L
P
F
Y
G
R
A
V
M
C
I
D
D
P
V
V
R
E
L
L
P
R
-
V
G
R
H
I
T
T
Y
G
F
S
D
D
A
-
D
V
Q
I
A
S
Y
R
Q
E
G
P
Q
G
H
F
T
L
R
R
Q
D
K
P
L
I
E
V
T
L
N
A
P
G
R
H
N
A
L
N
A
A
A
A
V
A
V
A
T
E
E
G
I
E
D
E
D
I
L
R
A
L
V
G
F
Q
G
T
G
R
R
F
D
F
L
G
----
N
--
F
-----
P
-----
L
-----
A
PVNGK
E
G
S
A
M
L
V
D
D
Y
G
H
H
P
T
E
V
D
A
T
I
K
A
A
R
A
G
W
P
D
K
R
I
V
M
L
F
Q
P
H
R
Y
T
R
T
R
D
L
Y
D
D
F
A
N
V
L
S
Q
V
D
V
L
L
M
L
D
V
Y
A
A
G
E
P
P
I
P
G
A
D
S
R
A
L
C
R
T
I
R
N
R
G
K
L
D
P
I
L
V
-
P
D
S
E
S
A
P
E
M
L
A
Q
I
L
N
G
E
D
L
I
L
V
Q
G
A
G
N
I
G
K
I
A
R
K
L
A
E
H
K
L
---
22
PsiBlast_CBE
87.03
60%
-68
- C1 -
-
4HV4
2
MURC_YERPE
B:
[18-483]
-----------------
E
M
R
R
V
R
H
I
H
F
V
G
I
G
G
A
G
M
G
G
I
A
E
V
L
A
N
E
G
Y
Q
I
S
G
S
D
L
A
P
-
N
S
V
T
Q
H
L
T
A
L
G
A
Q
I
Y
F
H
H
R
P
E
N
V
L
--
D
A
S
V
V
V
V
S
T
A
I
S
A
D
N
P
E
I
V
A
A
R
E
A
R
I
P
V
I
R
R
A
E
M
L
A
E
L
M
R
--
Y
R
H
G
I
-
A
V
A
G
T
H
G
K
T
T
T
T
A
M
L
S
S
I
Y
A
E
A
G
L
D
P
T
F
V
N
G
G
L
V
K
-
A
A
G
T
H
A
R
L
---------
G
S
S
R
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
I
V
T
N
I
E
A
D
-------
D
F
E
N
L
K
Q
T
F
I
N
F
L
H
N
L
P
F
Y
G
R
A
V
M
C
I
D
D
P
V
V
R
E
L
L
P
R
-
V
G
R
H
I
T
T
Y
G
F
S
D
D
A
-
D
V
Q
I
A
S
Y
R
Q
E
G
P
Q
G
H
F
T
L
R
R
Q
D
K
P
L
I
E
V
T
L
N
A
P
G
R
H
N
A
L
N
A
A
A
A
V
A
V
A
T
E
E
G
I
E
D
E
D
I
L
R
A
L
V
G
F
Q
G
T
G
R
R
F
D
F
L
G
----
N
--
F
-----
P
-----
L
-----
A
PVNGK
E
G
S
A
M
L
V
D
D
Y
G
H
H
P
T
E
V
D
A
T
I
K
A
A
R
A
G
W
P
D
K
R
I
V
M
L
F
Q
P
H
R
Y
T
R
T
R
D
L
Y
D
D
F
A
N
V
L
S
Q
V
D
V
L
L
M
L
D
V
Y
A
A
G
E
P
P
I
P
G
A
D
S
R
A
L
C
R
T
I
R
N
R
G
K
L
D
P
I
L
V
-
P
D
S
E
S
A
P
E
M
L
A
Q
I
L
N
G
E
D
L
I
L
V
Q
G
A
G
N
I
G
K
I
A
R
K
L
A
E
H
K
L
---
30
HHSearch
86.30
61%
-67
- C1 -
-
4HV4
2
MURC_YERPE
B:
[18-482]
-----------------
E
M
R
R
V
R
H
I
H
F
V
G
I
G
G
A
G
M
G
G
I
A
E
V
L
A
N
E
G
Y
Q
I
S
G
S
D
L
A
P
-
N
S
V
T
Q
H
L
T
A
L
G
A
Q
I
Y
F
H
H
R
P
E
N
V
L
--
D
A
S
V
V
V
V
S
T
A
I
S
A
D
N
P
E
I
V
A
A
R
E
A
R
I
P
V
I
R
R
A
E
M
L
A
E
L
M
R
--
Y
R
H
G
I
-
A
V
A
G
T
H
G
K
T
T
T
T
A
M
L
S
S
I
Y
A
E
A
G
L
D
P
T
F
V
N
G
G
L
V
K
-
A
A
G
T
H
A
R
L
---------
G
S
S
R
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
I
V
T
N
I
E
A
D
-------
D
F
E
N
L
K
Q
T
F
I
N
F
L
H
N
L
P
F
Y
G
R
A
V
M
C
I
D
D
P
V
V
R
E
L
L
P
R
-
V
G
R
H
I
T
T
Y
G
F
S
D
D
A
-
D
V
Q
I
A
S
Y
R
Q
E
G
P
Q
G
H
F
T
L
R
R
Q
D
K
P
L
I
E
V
T
L
N
A
P
G
R
H
N
A
L
N
A
A
A
A
V
A
V
A
T
E
E
G
I
E
D
E
D
I
L
R
A
L
V
G
F
Q
G
T
G
R
R
F
D
F
L
G
----
N
--
F
P
LAPV
N
-----
G
-----
K
-----
E
G
S
A
M
L
V
D
D
Y
G
H
H
P
T
E
V
D
A
T
I
K
A
A
R
A
G
W
P
D
K
R
I
V
M
L
F
Q
P
H
R
Y
T
R
T
R
D
L
Y
D
D
F
A
N
V
L
S
Q
V
D
V
L
L
M
L
D
V
Y
A
A
G
E
P
P
I
P
G
A
D
S
R
A
L
C
R
T
I
R
N
R
G
K
L
D
P
I
L
V
P
D
S
E
S
A
P
E
M
L
-
A
Q
I
L
N
G
E
D
L
I
L
V
Q
G
A
G
N
I
G
K
I
A
R
K
L
A
E
H
K
----
3
PsiBlast_PDB
84.95
60%
-68
- C1 -
-
2F00
-
MURC_ECOLI
A:
[13-477]
---------------
V
P
E
M
R
R
V
R
H
I
H
F
V
G
I
G
G
A
G
M
G
G
I
A
E
V
L
A
N
E
G
Y
Q
I
S
G
S
D
L
A
P
-
N
P
V
T
Q
Q
L
M
N
L
G
A
T
I
Y
F
N
H
R
P
E
N
V
R
--
D
A
S
V
V
V
V
S
S
A
I
S
A
D
N
P
E
I
V
A
A
H
E
A
R
I
P
V
I
R
R
A
E
M
L
A
E
L
M
R
--
F
R
H
G
I
-
A
I
A
G
T
H
G
K
T
T
T
T
A
M
V
S
S
I
Y
A
E
A
G
L
D
P
T
F
V
N
G
G
L
V
K
-
A
A
G
V
H
A
R
L
---------
G
H
G
R
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
I
V
T
N
I
E
A
D
H
M
D
T
Y
Q
G
D
F
E
N
L
K
Q
T
F
I
N
F
L
H
N
L
P
F
Y
G
R
A
V
M
C
V
D
D
P
V
I
R
E
L
L
P
R
-
V
G
R
Q
T
T
T
Y
G
F
S
E
D
A
-
D
V
R
V
E
D
Y
Q
Q
I
G
P
Q
G
H
F
T
L
L
R
Q
D
K
E
P
M
R
V
T
L
N
A
P
G
R
H
N
A
L
N
A
A
A
A
V
A
V
A
T
E
E
G
I
D
D
E
A
I
L
R
A
L
E
S
F
Q
G
T
G
R
R
F
D
F
L
G
----
E
--
F
-----
P
-----
L
EPVNG
K
-----
S
G
T
A
M
L
V
D
D
Y
G
H
H
P
T
E
V
D
A
T
I
K
A
A
R
A
G
W
P
D
K
N
L
V
M
L
F
Q
P
H
R
F
T
R
T
R
D
L
Y
D
D
F
A
N
V
L
T
Q
V
D
T
L
L
M
L
E
V
Y
P
A
G
E
A
P
I
P
G
A
D
S
R
S
L
C
R
T
-------
D
P
I
L
V
-
P
D
P
A
R
V
A
E
M
L
A
P
V
L
T
G
N
D
L
I
L
V
Q
G
A
G
N
I
G
K
I
A
R
S
L
A
E
------
31
HHSearch
84.20
58%
-68
- C1 -
-
1P3D
2
MURC_HAEIN
A:
[13-471]
----------------
P
E
M
R
R
V
Q
Q
I
H
F
I
G
I
G
G
A
G
M
S
G
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
-
G
V
V
T
Q
R
L
A
Q
A
G
A
K
I
Y
I
G
H
A
E
E
H
I
E
--
G
A
S
V
V
V
V
S
S
A
I
K
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
I
Q
R
A
Q
M
L
A
E
I
M
R
--
F
R
H
G
I
-
A
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
K
L
D
P
T
F
V
N
G
G
L
V
K
-
S
A
G
K
N
A
H
L
---------
G
A
S
R
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
E
G
D
F
E
K
M
K
A
T
Y
V
K
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
A
D
D
P
V
L
M
E
L
V
P
K
-
V
G
R
Q
V
I
T
Y
G
F
S
E
Q
A
-
D
Y
R
I
E
D
Y
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
N
N
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
E
F
I
R
P
--
N
------------------------
G
K
V
R
L
V
D
D
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
D
D
F
V
Q
V
L
S
Q
V
D
A
L
I
M
L
D
V
Y
A
A
G
E
A
P
I
V
G
A
D
S
K
S
L
C
R
S
I
R
N
L
G
K
V
D
P
I
L
V
S
D
T
S
Q
L
G
D
V
L
-
D
Q
I
I
Q
D
G
D
L
I
L
A
Q
G
A
G
S
V
S
K
I
S
R
G
L
A
E
------
32
HHSearch
82.73
58%
-74
- C1 -
-
1GQY
1
MURC_HAEIN
B:
[13-471]
----------------
P
E
M
R
R
V
Q
Q
I
H
F
I
G
I
G
G
A
G
M
S
G
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
-
G
V
V
T
Q
R
L
A
Q
A
G
A
K
I
Y
I
G
H
A
E
E
H
I
E
--
G
A
S
V
V
V
V
S
S
A
I
K
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
I
Q
R
A
Q
M
L
A
E
I
M
R
--
F
R
H
G
I
-
A
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
K
L
D
P
T
F
V
N
G
G
L
V
K
-
S
A
G
K
N
A
H
L
---------
G
A
S
R
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
E
G
D
F
E
K
M
K
A
T
Y
V
K
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
A
D
D
P
V
L
M
E
L
V
P
K
-
V
G
R
Q
V
I
T
Y
G
F
S
E
Q
A
-
D
Y
R
I
E
D
Y
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
N
N
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
E
F
I
R
P
--
N
------------------------
G
K
V
R
L
V
D
D
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
D
D
F
V
Q
V
L
S
Q
V
D
A
L
I
M
L
D
V
Y
A
A
G
E
A
P
I
V
G
A
D
S
K
S
L
C
R
S
I
R
N
L
G
K
V
D
P
I
L
V
S
D
T
S
Q
L
G
D
V
L
-
D
Q
I
I
Q
D
G
D
L
I
L
A
Q
G
A
G
S
V
S
K
I
S
R
G
L
A
E
------
28
HHSearch
82.04
62%
-32
- C1 -
-
2F00
-
MURC_ECOLI
B:
[7-476]
---------
A
K
L
R
S
I
V
P
E
M
R
R
V
R
H
I
H
F
V
G
I
G
G
A
G
M
G
G
I
A
E
V
L
A
N
E
G
Y
Q
I
S
G
S
D
L
A
P
-
N
P
V
T
Q
Q
L
M
N
L
G
A
T
I
Y
F
N
H
R
P
E
N
V
R
--
D
A
S
V
V
V
V
S
S
A
I
S
A
D
N
P
E
I
V
A
A
H
E
A
R
I
P
V
I
R
R
A
E
M
L
A
E
L
M
R
--
F
R
H
G
I
-
A
I
A
G
T
H
G
K
T
T
T
T
A
M
V
S
S
I
Y
A
E
A
G
L
D
P
T
F
-
V
N
G
G
L
V
K
A
A
G
V
H
A
R
L
---------
G
H
G
R
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
I
V
T
N
I
E
A
D
H
M
D
T
Y
Q
G
D
F
E
N
L
K
Q
T
F
I
N
F
L
H
N
L
P
F
Y
G
R
A
V
M
C
V
D
D
P
V
I
R
E
L
L
P
R
-
V
G
R
Q
T
T
T
Y
G
F
S
E
D
A
-
D
V
R
V
E
D
Y
Q
Q
I
G
P
Q
G
H
F
T
L
L
R
Q
D
K
E
P
M
R
V
T
L
N
A
P
G
R
H
N
A
L
N
A
A
A
A
V
A
V
A
T
E
E
G
I
D
D
E
A
I
L
R
A
L
E
S
F
Q
G
T
G
R
R
F
D
F
L
G
----
E
--
F
-----
P
LEPVN
G
-----
K
-----
S
G
T
A
M
L
V
D
D
Y
G
H
H
P
T
E
V
D
A
T
I
K
A
A
R
A
G
W
P
D
K
N
L
V
M
L
F
Q
P
H
R
F
T
R
T
R
D
L
Y
D
D
F
A
N
V
L
T
Q
V
D
T
L
L
M
L
E
V
Y
P
A
G
E
A
P
I
P
G
A
D
S
R
S
L
C
R
T
I
R
G
R
G
K
I
D
P
I
L
V
P
D
P
A
R
V
A
E
M
L
-
A
P
V
L
T
G
N
D
L
I
L
V
Q
G
A
G
N
I
G
K
I
A
R
S
L
A
-------
36
HHSearch
77.04
68%
-119
- C1 -
-
5VVW
3
?
G:
[8-312]
---------------------
H
R
R
I
H
F
V
G
I
G
G
A
G
M
C
G
I
A
E
V
L
L
N
L
G
Y
E
V
S
G
S
D
L
K
A
-
S
A
V
T
E
R
L
E
K
F
G
A
Q
I
F
I
G
H
Q
A
E
N
A
D
--
G
A
D
V
L
V
V
S
S
A
I
N
R
A
N
P
E
V
A
S
A
L
E
R
R
I
P
V
V
P
R
A
E
M
L
A
E
L
M
R
--
Y
R
H
G
I
-
A
V
A
G
T
H
G
K
T
T
T
T
S
L
I
A
S
V
F
A
A
G
G
L
D
P
T
F
V
I
G
G
R
L
N
-
A
A
G
T
N
A
Q
L
---------
G
A
S
R
Y
L
V
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
V
V
T
N
I
D
A
D
H
M
A
T
Y
G
G
D
F
N
K
L
K
K
T
F
V
E
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
V
D
D
P
V
V
R
E
I
L
P
Q
-
I
A
R
P
T
V
T
Y
G
L
S
E
D
A
-
D
V
R
A
I
N
I
R
Q
E
G
M
R
T
W
F
T
V
L
R
P
E
R
E
P
L
D
V
S
V
N
M
P
G
L
H
N
V
L
N
S
L
A
T
I
V
I
A
T
D
E
G
I
S
D
E
A
I
V
Q
G
L
S
G
F
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
75.20
68%
-119
- C1 -
-
5VVW
1
?
H:
[13-312]
--------------------------
F
V
G
I
G
G
A
G
M
C
G
I
A
E
V
L
L
N
L
G
Y
E
V
S
G
S
D
L
K
A
-
S
A
V
T
E
R
L
E
K
F
G
A
Q
I
F
I
G
H
Q
A
E
N
A
D
--
G
A
D
V
L
V
V
S
S
A
I
N
R
A
N
P
E
V
A
S
A
L
E
R
R
I
P
V
V
P
R
A
E
M
L
A
E
L
M
R
--
Y
R
H
G
I
-
A
V
A
G
T
H
G
K
T
T
T
T
S
L
I
A
S
V
F
A
A
G
G
L
D
P
T
F
V
I
G
G
R
L
N
-
A
A
G
T
N
A
Q
L
---------
G
A
S
R
Y
L
V
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
V
V
T
N
I
D
A
D
H
M
A
T
Y
G
G
D
F
N
K
L
K
K
T
F
V
E
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
V
D
D
P
V
V
R
E
I
L
P
Q
-
I
A
R
P
T
V
T
Y
G
L
S
E
D
A
-
D
V
R
A
I
N
I
R
Q
E
G
M
R
T
W
F
T
V
L
R
P
E
R
E
P
L
D
V
S
V
N
M
P
G
L
H
N
V
L
N
S
L
A
T
I
V
I
A
T
D
E
G
I
S
D
E
A
I
V
Q
G
L
S
G
F
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
74.72
68%
-124
- C1 -
-
5VVW
1
?
B:
[13-312]
--------------------------
F
V
G
I
G
G
A
G
M
C
G
I
A
E
V
L
L
N
L
G
Y
E
V
S
G
S
D
L
K
A
-
S
A
V
T
E
R
L
E
K
F
G
A
Q
I
F
I
G
H
Q
A
E
N
A
D
--
G
A
D
V
L
V
V
S
S
A
I
N
R
A
N
P
E
V
A
S
A
L
E
R
R
I
P
V
V
P
R
A
E
M
L
A
E
L
M
R
--
Y
R
H
G
I
-
A
V
A
G
T
H
G
K
T
T
T
T
S
L
I
A
S
V
F
A
A
G
G
L
D
P
T
F
V
I
G
G
R
L
N
-
A
A
G
T
N
A
Q
L
---------
G
A
S
R
Y
L
V
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
V
V
T
N
I
D
A
D
H
M
A
T
Y
G
G
D
F
N
K
L
K
K
T
F
V
E
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
V
D
D
P
V
V
R
E
I
L
P
Q
-
I
A
R
P
T
V
T
Y
G
L
S
E
D
A
-
D
V
R
A
I
N
I
R
Q
E
G
M
R
T
W
F
T
V
L
R
P
E
R
E
P
L
D
V
S
V
N
M
P
G
L
H
N
V
L
N
S
L
A
T
I
V
I
A
T
D
E
G
I
S
D
E
A
I
V
Q
G
L
S
G
F
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.70
68%
-122
- C1 -
-
5VVW
1
?
A:
[13-312]
--------------------------
F
V
G
I
G
G
A
G
M
C
G
I
A
E
V
L
L
N
L
G
Y
E
V
S
G
S
D
L
K
A
-
S
A
V
T
E
R
L
E
K
F
G
A
Q
I
F
I
G
H
Q
A
E
N
A
D
--
G
A
D
V
L
V
V
S
S
A
I
N
R
A
N
P
E
V
A
S
A
L
E
R
R
I
P
V
V
P
R
A
E
M
L
A
E
L
M
R
--
Y
R
H
G
I
-
A
V
A
G
T
H
G
K
T
T
T
T
S
L
I
A
S
V
F
A
A
G
G
L
D
P
T
F
V
I
G
G
R
L
N
-
A
A
G
T
N
A
Q
L
---------
G
A
S
R
Y
L
V
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
V
V
T
N
I
D
A
D
H
M
A
T
Y
G
G
D
F
N
K
L
K
K
T
F
V
E
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
V
D
D
P
V
V
R
E
I
L
P
Q
-
I
A
R
P
T
V
T
Y
G
L
S
E
D
A
-
D
V
R
A
I
N
I
R
Q
E
G
M
R
T
W
F
T
V
L
R
P
E
R
E
P
L
D
V
S
V
N
M
P
G
L
H
N
V
L
N
S
L
A
T
I
V
I
A
T
D
E
G
I
S
D
E
A
I
V
Q
G
L
S
G
F
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
74.64
68%
-123
- C1 -
-
5VVW
1
?
C:
[13-312]
--------------------------
F
V
G
I
G
G
A
G
M
C
G
I
A
E
V
L
L
N
L
G
Y
E
V
S
G
S
D
L
K
A
-
S
A
V
T
E
R
L
E
K
F
G
A
Q
I
F
I
G
H
Q
A
E
N
A
D
--
G
A
D
V
L
V
V
S
S
A
I
N
R
A
N
P
E
V
A
S
A
L
E
R
R
I
P
V
V
P
R
A
E
M
L
A
E
L
M
R
--
Y
R
H
G
I
-
A
V
A
G
T
H
G
K
T
T
T
T
S
L
I
A
S
V
F
A
A
G
G
L
D
P
T
F
V
I
G
G
R
L
N
-
A
A
G
T
N
A
Q
L
---------
G
A
S
R
Y
L
V
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
V
V
T
N
I
D
A
D
H
M
A
T
Y
G
G
D
F
N
K
L
K
K
T
F
V
E
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
V
D
D
P
V
V
R
E
I
L
P
Q
-
I
A
R
P
T
V
T
Y
G
L
S
E
D
A
-
D
V
R
A
I
N
I
R
Q
E
G
M
R
T
W
F
T
V
L
R
P
E
R
E
P
L
D
V
S
V
N
M
P
G
L
H
N
V
L
N
S
L
A
T
I
V
I
A
T
D
E
G
I
S
D
E
A
I
V
Q
G
L
S
G
F
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
74.41
68%
-118
- C1 -
-
5VVW
3
?
G:
[13-312]
--------------------------
F
V
G
I
G
G
A
G
M
C
G
I
A
E
V
L
L
N
L
G
Y
E
V
S
G
S
D
L
K
A
-
S
A
V
T
E
R
L
E
K
F
G
A
Q
I
F
I
G
H
Q
A
E
N
A
D
--
G
A
D
V
L
V
V
S
S
A
I
N
R
A
N
P
E
V
A
S
A
L
E
R
R
I
P
V
V
P
R
A
E
M
L
A
E
L
M
R
--
Y
R
H
G
I
-
A
V
A
G
T
H
G
K
T
T
T
T
S
L
I
A
S
V
F
A
A
G
G
L
D
P
T
F
V
I
G
G
R
L
N
-
A
A
G
T
N
A
Q
L
---------
G
A
S
R
Y
L
V
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
V
V
T
N
I
D
A
D
H
M
A
T
Y
G
G
D
F
N
K
L
K
K
T
F
V
E
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
V
D
D
P
V
V
R
E
I
L
P
Q
-
I
A
R
P
T
V
T
Y
G
L
S
E
D
A
-
D
V
R
A
I
N
I
R
Q
E
G
M
R
T
W
F
T
V
L
R
P
E
R
E
P
L
D
V
S
V
N
M
P
G
L
H
N
V
L
N
S
L
A
T
I
V
I
A
T
D
E
G
I
S
D
E
A
I
V
Q
G
L
S
G
F
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
60.65
29%
-20
- C1 -
-
1J6U
-
MURC_THEMA
A:
[0-440]
---------------------
H
M
K
I
H
F
V
G
I
G
G
I
G
M
S
A
V
A
L
H
E
F
S
N
G
N
D
V
Y
G
S
N
I
E
E
-
T
E
R
T
A
Y
L
R
K
L
G
I
P
I
F
V
P
H
S
A
D
N
W
Y
--
D
P
D
L
V
I
K
T
P
A
V
R
D
D
N
P
E
I
V
R
A
R
M
E
R
V
P
I
E
N
R
L
H
Y
F
R
D
T
L
K
R
E
K
K
E
E
F
-
A
V
T
G
T
D
G
K
T
T
T
T
A
M
V
A
H
V
L
K
H
L
R
K
S
P
T
V
F
L
G
G
I
M
D
-
S
L
E
H
G
N
Y
E
---------
K
G
N
G
P
V
V
Y
E
L
D
E
S
E
E
F
F
S
-------
E
F
S
P
N
Y
L
I
I
T
N
A
R
G
D
H
L
E
N
Y
G
N
S
L
T
R
Y
R
S
A
F
E
K
I
S
R
N
T
---
D
L
V
V
T
F
A
E
D
E
L
T
S
H
L
G
-------
D
V
T
F
G
V
K
K
G
--
T
Y
T
L
E
M
R
S
A
S
R
A
E
Q
K
A
M
V
E
K
N
G
K
R
Y
L
E
L
K
L
K
V
P
G
F
H
N
V
L
N
A
L
A
V
I
A
L
F
D
S
L
G
Y
D
L
A
P
V
L
E
A
L
E
E
F
R
G
V
H
R
R
F
S
I
A
F
----
H
DP
E
------------------------
T
N
I
Y
V
I
D
D
Y
A
H
T
P
D
E
I
R
N
L
L
Q
T
A
K
E
V
F
E
N
E
K
I
V
V
I
F
Q
P
H
R
--------
G
N
F
A
K
A
L
Q
L
A
D
E
V
V
V
T
E
V
Y
D
---------
S
G
K
M
I
W
D
S
L
K
S
L
G
K
-
E
A
Y
F
V
E
K
L
P
E
L
E
K
V
I
---
S
V
S
E
N
T
V
F
L
F
V
G
A
G
D
I
I
Y
S
S
R
R
F
V
E
------
7
PsiBlast_PDB
58.15
29%
-19
- C1 -
-
1J6U
-
MURC_THEMA
A:
[5-431]
--------------------------
F
V
G
I
G
G
I
G
M
S
A
V
A
L
H
E
F
S
N
G
N
D
V
Y
G
S
N
I
E
E
-
T
E
R
T
A
Y
L
R
K
L
G
I
P
I
F
V
P
H
S
A
D
N
W
Y
--
D
P
D
L
V
I
K
T
P
A
V
R
D
D
N
P
E
I
V
R
A
R
M
E
R
V
P
I
E
N
R
L
H
Y
F
R
D
T
L
K
R
E
K
K
E
E
F
-
A
V
T
G
T
D
G
K
T
T
T
T
A
M
V
A
H
V
L
K
H
L
R
K
S
P
T
V
F
L
G
G
I
M
D
-
S
L
E
H
G
N
Y
E
---------
K
G
N
G
P
V
V
Y
E
L
D
E
S
E
E
F
F
S
-------
E
F
S
P
N
Y
L
I
I
T
N
A
R
G
D
H
L
E
N
Y
G
N
S
L
T
R
Y
R
S
A
F
E
K
I
S
R
N
T
---
D
L
V
V
T
F
A
E
D
----
E
L
T
S
H
-
L
G
D
--
V
T
F
G
V
K
K
G
T
Y
T
L
E
M
R
S
A
S
R
A
E
Q
K
A
--
M
V
E
K
N
G
K
R
Y
L
E
L
K
L
K
V
P
G
F
H
N
V
L
N
A
L
A
V
I
A
L
F
D
S
L
G
Y
D
L
A
P
V
L
E
A
L
E
E
F
R
G
V
H
R
R
F
S
I
A
--------
F
-----
H
-----
D
-----
P
-----
E
T
N
I
Y
V
I
D
D
Y
A
H
T
P
D
E
I
R
N
L
L
Q
T
A
K
E
V
F
E
N
E
K
I
V
V
I
F
Q
P
H
R
--------
G
N
F
A
K
A
L
Q
L
A
D
E
V
V
V
T
E
V
Y
D
---------
S
G
K
M
I
W
D
S
L
K
S
L
G
K
-
E
A
Y
F
V
E
K
L
P
-
E
L
E
K
V
I
S
--
V
S
E
N
T
V
F
L
F
V
G
A
G
D
I
---------------
9
PsiBlast_PDB
48.58
31%
-22
- C1 -
-
3EAG
2
?
A:
[5-326]
----------------------
K
H
I
H
I
I
G
I
G
G
T
F
M
G
G
L
A
A
I
A
K
E
A
G
F
E
V
S
G
C
D
A
K
M
Y
P
P
M
S
T
Q
L
E
A
L
G
I
D
V
Y
E
G
F
D
A
A
Q
L
D
EF
K
A
D
V
Y
V
I
G
N
V
A
K
R
G
M
D
V
V
E
A
I
L
N
L
G
L
P
Y
I
S
G
P
Q
W
L
S
E
N
V
L
--
H
H
H
W
V
L
G
V
A
G
T
H
G
K
T
T
T
A
S
M
L
A
W
V
L
E
Y
A
G
L
A
P
G
F
L
I
G
G
V
P
E
-
N
F
G
V
S
A
R
L
PQTPRQDPN
S
Q
S
P
F
F
V
I
E
A
D
E
Y
D
T
A
F
F
DKRSKFV
H
Y
R
P
R
T
A
V
L
N
N
L
E
F
D
H
A
D
I
F
-
A
D
L
G
A
I
Q
T
Q
F
H
Y
L
V
R
T
V
P
S
E
G
L
I
V
C
N
G
R
Q
Q
S
L
Q
D
T
L
D
K
G
C
W
T
P
V
E
K
F
G
--
T
E
H
-
G
W
Q
A
G
E
A
N
A
D
G
S
---
F
D
V
L
L
D
G
K
T
A
G
R
V
K
W
D
L
M
G
R
H
N
R
M
N
A
L
A
V
I
A
A
A
R
H
V
G
V
D
I
Q
T
A
C
E
A
L
G
A
F
K
N
V
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------