@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNZ9: (2017-11-19 )
MTDSQQSKPKHVMMMAAGTGGHVFPALAVAKQLQQQGCQVSWLATPIGMENRLLKDQNIPIYQIDIQGVRGNGVIRKLAAPFKILKATFSAMRYMKQLKVDAVAGFGGYVAGPGGLAARLLGIPVLIHEQNAVAGFTNAQLSRVAKVVCEAFPNTFPASEKVVTTGNPVRREITDILSPKWRYDEREQAGKPLNILIVGGSLGAKALNERLPPALKQLQVPLNIFHQCGQQQVEATQALYADAPANLTVQVLPFIEDMAKAYSEADLIICRAGALTVTEVATAGVAAVFVPLPIAVDDHQTANAKFLADVGAAKICQQSTMTPEVLNQLFTTLMNRQLLTEMAVKARQHAQPNATQHVVGLIQKM
Atome Classification :
(20 SA)
.........10........20........30........40........50........60......--.--.-70-.--.------.---.--------------.-------.-----.----..----80.---..--------....-..90........100.....-..110........120.......130..---------------.---.----------------------.----------------------.--------------------.140-------------..--------------.-----------------.-----------------.----------------.----..150...-----------.-----------.---.---.----------160--------------........170.......180......--.---190.-......200.-------.---.---....210.....--..220.....--..230.-----.....--.240........250.......260.......270.......280.......290.......----300.......310....-...320.......330.......-340.......350.......360...------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTDSQQSKP
K
H
V
M
M
M
A
AGTGG
H
V
F
P
A
L
A
V
A
K
Q
L
Q
Q
QG
C
Q
V
S
W
L
ATPIGMENRLLKDQNI
P
I
Y
Q
I
D
IQ--G--V-R--G--N------
G
---
V
--------------
I
-------
R
-----
K
----
L
A
----
A
-
P
---
F
K
--------
I
L
K
A
-
T
F
S
A
M
R
Y
M
K
Q
LKV
D
A
VAGFG-GYVA-G
P
G
G
L
A
A
R
L
LG
I
P
V
L
I
HEQNAVA---------------G---F----------------------
T
----------------------
N
--------------------
A
Q
L
--------------
S
R
--------------
V
-----------------
A
-----------------
K
----------------
V
----
V
C
E
AFPNT-----------F-----------P---A---S----------E
K
---------------
V
VTTGN
P
V
R
R
E
I
T
D
ILSPKWR
Y
D
E
R
EQ--A---GK
P
L
-
N
I
L
I
VGGS
L
G
-------
A
---
K
---
A
L
N
E
RL
P
P
A
L
K
Q
--
L
Q
V
P
L
N
I
F
H
Q
--C
G
Q
Q
Q
V
-----
E
A
T
Q
A
--
L
Y-ADAPA
N
L
T
V
Q
V
L
P
F
I
E
D
M
A
K
AYSEA
D
L
I
I
CRAGAL
T
V
T
E
VATAG
V
A
A
V
F
V
P
L
P
I
A
VDDH----QTAN
A
K
F
L
A
D
V
G
A
A
K
I
C
-
Q
QSTM
T
P
E
V
L
N
Q
L
F
T
T
L
M
N
R
Q
L
L
-
T
E
M
A
V
K
A
R
QHAQPN
A
T
Q
H
V
V
G
L
I
QKM------
2
PsiBlast_PDB
87.39
43%
-120
- C4 -
-
1F0K
-
MURG_ECOLI
A:
[7-353]
---------
K
R
L
M
V
M
A
G
G
T
G
G
H
V
F
P
G
L
A
V
A
H
H
L
M
A
Q
G
W
Q
V
R
W
L
G
T
A
D
R
M
E
A
D
L
V
P
K
H
G
I
E
I
D
F
I
R
I
S
--
G
--
L
-
R
--
G
--
K
------
G
---
I
--------------
K
-------
A
-----
L
----
I
A
----
A
-
P
---
L
R
--------
I
F
N
A
-
W
R
Q
A
R
A
I
M
K
A
Y
K
P
D
V
V
L
G
M
G
-
G
Y
V
S
-
G
P
G
G
L
A
A
W
S
L
G
I
P
V
V
L
H
E
Q
N
G
I
A
---------------
G
---
L
----------------------
T
----------------------
N
--------------------
K
W
L
--------------
A
K
--------------
I
-----------------
A
-----------------
T
----------------
K
----
V
M
Q
A
F
P
G
A
-----------
F
-----------
P
---
N
---
A
----------
E
V
---------------
V
---
G
N
P
V
R
T
D
V
L
A
L
P
L
P
Q
Q
R
L
A
G
R
E
--------
G
P
V
-
R
V
L
V
V
G
G
S
Q
G
-------
A
---
R
---
I
L
N
Q
T
M
P
Q
V
A
A
K
--
L
G
D
S
V
T
I
W
H
Q
--
S
G
K
G
S
Q
-----
Q
S
V
E
Q
--
A
Y
-
A
E
A
-
G
Q
P
Q
H
K
V
T
E
F
I
D
D
M
A
A
A
Y
A
W
A
D
V
V
V
C
R
S
G
A
L
T
V
S
E
I
A
A
A
G
L
P
A
L
F
V
P
F
Q
H
K
-
D
R
Q
----
Q
Y
W
N
A
L
P
L
E
K
A
G
A
A
K
I
I
-
E
Q
P
Q
L
S
V
D
A
V
A
N
T
L
A
G
W
S
R
E
T
L
L
-
T
-
M
A
E
R
A
R
A
A
S
I
P
D
A
T
E
R
V
A
N
E
V
S
R
V
------
47
Fugue
87.26
43%
-120
- C4 -
-
1F0K
-
MURG_ECOLI
A:
[7-357]
---------
K
R
L
M
V
M
A
G
G
T
G
G
H
V
F
P
G
L
A
V
A
H
H
L
M
A
Q
G
W
Q
V
R
W
L
G
T
A
D
R
M
E
A
D
L
V
P
K
H
G
I
E
I
D
F
I
R
I
S
--
G
--
L
-
R
--
G
--
K
------
G
---
I
--------------
K
-------
A
-----
L
----
I
A
----
A
-
P
---
L
R
--------
I
F
N
A
-
W
R
Q
A
R
A
I
M
K
A
Y
K
P
D
V
V
L
G
M
G
-
G
Y
V
S
-
G
P
G
G
L
A
A
W
S
L
G
I
P
V
V
L
H
E
Q
N
G
I
A
---------------
G
---
L
----------------------
T
----------------------
N
--------------------
K
W
L
--------------
A
K
--------------
I
-----------------
A
-----------------
T
----------------
K
----
V
M
Q
A
F
P
G
A
-----------
F
-----------
P
-------------------
N
---------------
A
E
V
V
G
N
P
V
R
T
D
V
L
A
L
P
L
P
Q
Q
R
L
A
G
R
E
--------
G
P
V
-
R
V
L
V
V
G
G
S
Q
G
-------
A
---
R
---
I
L
N
Q
T
M
P
Q
V
A
A
K
--
L
G
D
S
V
T
I
W
H
Q
--
S
G
K
G
S
Q
-----
Q
S
V
E
Q
--
A
Y
-
A
E
-
A
G
Q
P
Q
H
K
V
T
E
F
I
D
D
M
A
A
A
Y
A
W
A
D
V
V
V
C
R
S
G
A
L
T
V
S
E
I
A
A
A
G
L
P
A
L
F
V
P
F
Q
H
K
-
D
R
Q
----
Q
Y
W
N
A
L
P
L
E
K
A
G
A
A
K
I
I
-
E
Q
P
Q
L
S
V
D
A
V
A
N
T
L
A
G
W
-
S
R
E
T
L
-
L
T
M
A
E
R
A
R
A
A
S
I
P
D
A
T
E
R
V
A
N
E
V
S
R
V
A
R
AL--
3
PsiBlast_PDB
87.24
43%
-116
- C4 -
-
1NLM
5
MURG_ECOLI
A:
[7-353]
---------
K
R
L
M
V
M
A
G
G
T
G
G
H
V
F
P
G
L
A
V
A
H
H
L
M
A
Q
G
W
Q
V
R
W
L
G
T
A
D
R
M
E
A
D
L
V
P
K
H
G
I
E
I
D
F
I
R
I
S
--
G
--
L
-
R
--
G
--
K
------
G
---
I
--------------
K
-------
A
-----
L
----
I
A
----
A
-
P
---
L
R
--------
I
F
N
A
-
W
R
Q
A
R
A
I
M
K
A
Y
K
P
D
V
V
L
G
M
G
-
G
Y
V
S
-
G
P
G
G
L
A
A
W
S
L
G
I
P
V
V
L
H
E
Q
N
G
I
A
---------------
G
---
L
----------------------
T
----------------------
N
--------------------
K
W
L
--------------
A
K
--------------
I
-----------------
A
-----------------
T
----------------
K
----
V
M
Q
A
F
P
G
A
-----------
F
-----------
P
---
N
---
A
----------
E
V
---------------
V
---
G
N
P
V
R
T
D
V
L
A
L
P
L
P
Q
Q
R
L
A
G
R
E
--------
G
P
V
-
R
V
L
V
V
G
G
S
Q
G
-------
A
---
R
---
I
L
N
Q
T
M
P
Q
V
A
A
K
--
L
G
D
S
V
T
I
W
H
Q
--
S
G
K
G
S
Q
-----
Q
S
V
E
Q
--
A
Y
-
A
E
A
-
G
Q
P
Q
H
K
V
T
E
F
I
D
D
M
A
A
A
Y
A
W
A
D
V
V
V
C
R
S
G
A
L
T
V
S
E
I
A
A
A
G
L
P
A
L
F
V
P
F
Q
H
K
-
D
R
Q
----
Q
Y
W
N
A
L
P
L
E
K
A
G
A
A
K
I
I
-
E
Q
P
Q
L
S
V
D
A
V
A
N
T
L
A
G
W
S
R
E
T
L
L
-
T
-
M
A
E
R
A
R
A
A
S
I
P
D
A
T
E
R
V
A
N
E
V
S
R
V
------
21
PsiBlast_CBE
85.84
43%
-118
- C4 -
-
1NLM
2
MURG_ECOLI
B:
[7-353]
---------
K
R
L
M
V
M
A
G
G
T
G
G
H
V
F
P
G
L
A
V
A
H
H
L
M
A
Q
G
W
Q
V
R
W
L
G
T
A
D
R
M
E
A
D
L
V
P
K
H
G
I
E
I
D
F
I
R
I
S
--
G
--
L
-
R
--
G
--
K
------
G
---
I
--------------
K
-------
A
-----
L
----
I
A
----
A
-
P
---
L
R
--------
I
F
N
A
-
W
R
Q
A
R
A
I
M
K
A
Y
K
P
D
V
V
L
G
M
G
-
G
Y
V
S
-
G
P
G
G
L
A
A
W
S
L
G
I
P
V
V
L
H
E
Q
N
G
I
A
---------------
G
---
L
----------------------
T
----------------------
N
--------------------
K
W
L
--------------
A
K
--------------
I
-----------------
A
-----------------
T
----------------
K
----
V
M
Q
A
F
P
G
A
-----------
F
-----------
P
---
N
---
A
----------
E
V
---------------
V
---
G
N
P
V
R
T
D
V
L
A
L
P
L
P
Q
Q
R
L
A
G
R
E
--------
G
P
V
-
R
V
L
V
V
G
G
S
Q
G
-------
A
---
R
---
I
L
N
Q
T
M
P
Q
V
A
A
K
--
L
G
D
S
V
T
I
W
H
Q
--
S
G
K
G
S
Q
-----
Q
S
V
E
Q
--
A
Y
-
A
E
A
-
G
Q
P
Q
H
K
V
T
E
F
I
D
D
M
A
A
A
Y
A
W
A
D
V
V
V
C
R
S
G
A
L
T
V
S
E
I
A
A
A
G
L
P
A
L
F
V
P
F
Q
H
K
-
D
R
Q
----
Q
Y
W
N
A
L
P
L
E
K
A
G
A
A
K
I
I
-
E
Q
P
Q
L
S
V
D
A
V
A
N
T
L
A
G
W
S
R
E
T
L
L
-
T
-
M
A
E
R
A
R
A
A
S
I
P
D
A
T
E
R
V
A
N
E
V
S
R
V
------
1
PsiBlast_PDB
81.39
49%
-64
- C4 -
-
3S2U
1
MURG_PSEAE
A:
[4-348]
----------
N
V
L
I
M
A
G
G
T
G
G
H
V
F
P
A
L
A
C
A
R
E
F
Q
A
R
G
Y
A
V
H
W
L
G
T
P
R
G
I
E
N
D
L
V
P
K
A
G
L
P
L
H
L
I
Q
------------------------------------------------------------------
A
-
P
---
L
E
--------
L
L
K
S
-
L
F
Q
A
L
R
V
I
R
Q
L
R
P
V
C
V
L
G
L
G
-
G
Y
V
T
-
G
P
G
G
L
A
A
R
L
N
G
V
P
L
V
I
H
E
Q
N
A
V
A
---------------
G
---
T
----------------------
A
----------------------
N
--------------------
R
S
L
--------------
A
P
--------------
I
-----------------
A
-----------------
R
----------------
R
----
V
C
E
A
F
P
D
T
-----------
F
-----------
P
---
A
-------------------------------
R
L
T
T
G
N
P
V
R
G
E
L
F
--------
L
D
A
H
A
R
--
A
PLT
G
R
R
V
-
N
L
L
V
L
G
G
S
L
G
-------
A
---
E
---
P
L
N
K
L
L
P
E
A
L
A
Q
VP
L
E
I
R
P
A
I
R
H
Q
--
A
G
R
Q
H
A
-----
E
I
T
A
E
--
R
Y
-
R
T
--
V
A
V
E
A
D
V
A
P
F
I
S
D
M
A
A
A
Y
A
W
A
D
L
V
I
C
R
A
G
A
L
T
V
S
E
L
T
A
A
G
L
P
A
F
L
V
P
-----
D
D
H
----
Q
T
R
N
A
E
F
L
V
R
S
G
A
G
R
L
L
P
Q
K
S
T
G
A
A
E
L
A
A
Q
L
S
E
V
L
M
H
P
E
T
L
-
R
S
M
A
D
Q
A
R
S
L
A
K
P
E
A
T
R
T
V
V
------------
29
HHSearch
80.95
41%
-71
- C4 -
-
1F0K
-
MURG_ECOLI
A:
[7-352]
---------
K
R
L
M
V
M
A
G
G
T
G
G
H
V
F
P
G
L
A
V
A
H
H
L
M
A
Q
G
W
Q
V
R
W
L
G
T
A
D
R
M
E
A
D
L
V
P
K
H
G
I
E
I
D
F
I
R
I
S
--
G
--
L
-
R
--
G
--
K
------
G
---
I
--------------
K
-------
A
-----
L
----
I
A
----
A
-
P
---
L
R
--------
I
F
N
A
-
W
R
Q
A
R
A
I
M
K
A
Y
K
P
D
V
V
L
G
M
G
-
G
Y
V
S
-
G
P
G
G
L
A
A
W
S
L
G
I
P
V
V
L
H
E
Q
N
G
I
A
---------------
G
---
L
----------------------
T
----------------------
N
--------------------
K
W
L
--------------
A
K
--------------
I
-----------------
A
-----------------
T
----------------
K
----
V
M
Q
A
F
P
G
A
-------------------------------
F
----------
P
N
---------------
A
E
V
V
G
N
P
V
R
T
D
V
L
A
L
P
L
P
---
Q
Q
R
L
A
G
--
R
---
E
G
P
V
-
R
V
L
V
V
G
G
S
Q
G
-------
A
---
R
---
I
L
N
Q
T
M
P
Q
V
A
A
K
--
L
G
D
S
V
T
I
W
H
Q
--
S
G
K
G
S
Q
-----
Q
S
V
E
Q
--
A
Y
A
E
A
G
Q
P
Q
--
H
K
V
T
E
F
I
D
D
M
A
A
A
Y
A
W
A
D
V
V
V
C
R
S
G
A
L
T
V
S
E
I
A
A
A
G
L
P
A
L
F
V
P
F
Q
H
-
K
D
R
Q
----
Q
Y
W
N
A
L
P
L
E
K
A
G
A
A
K
I
I
-
E
Q
P
Q
L
S
V
D
A
V
A
N
T
L
A
G
W
--
S
R
E
T
L
L
T
M
A
E
R
A
R
A
A
S
I
P
D
A
T
E
R
V
A
N
E
V
S
R
-------
27
HHSearch
80.62
47%
-81
- C4 -
-
3S2U
1
MURG_PSEAE
A:
[3-352]
---------
G
N
V
L
I
M
A
G
G
T
G
G
H
V
F
P
A
L
A
C
A
R
E
F
Q
A
R
G
Y
A
V
H
W
L
G
T
P
R
G
I
E
N
D
L
V
P
K
A
G
L
P
L
H
L
I
Q
------------------------------------------------------------------
A
-
P
---
L
E
--------
L
L
K
S
-
L
F
Q
A
L
R
V
I
R
Q
L
R
P
V
C
V
L
G
L
G
-
G
Y
V
T
-
G
P
G
G
L
A
A
R
L
N
G
V
P
L
V
I
H
E
Q
N
A
V
A
---------------
G
---
T
----------------------
A
----------------------
N
--------------------
R
S
L
--------------
A
P
--------------
I
-----------------
A
-----------------
R
----------------
R
----
V
C
E
A
F
P
D
T
-----------
F
-----------
P
---
A
-------------------------------
R
L
T
T
G
N
P
V
R
G
E
L
F
L
D
A
-
H
----
A
R
A
P
L
--
T
---
G
R
R
V
-
N
L
L
V
L
G
G
S
L
G
-------
A
---
E
---
P
L
N
K
L
L
P
E
A
L
A
Q
--
V
P
L
E
I
R
P
A
I
R
H
Q
A
G
R
Q
H
A
-----
E
I
T
A
E
--
R
Y
-
R
T
V
A
V
E
--
A
D
V
A
P
F
I
S
D
M
A
A
A
Y
A
W
A
D
L
V
I
C
R
A
G
A
L
T
V
S
E
L
T
A
A
G
L
P
A
F
L
V
P
-----
D
D
H
----
Q
T
R
N
A
E
F
L
V
R
S
G
A
G
R
L
L
-
P
Q
K
S
T
G
A
A
E
L
A
A
Q
L
S
E
V
L
M
H
P
E
T
L
R
S
M
A
D
Q
A
R
S
L
A
K
P
E
A
T
R
T
V
V
D
A
C
L
--------
48
Fugue
77.88
41%
-32
- C4 -
-
1F0K
-
MURG_ECOLI
A:
[7-357]
---------
K
R
L
M
V
M
A
G
G
T
G
G
H
V
F
P
G
L
A
V
A
H
H
L
M
A
Q
G
W
Q
V
R
W
L
G
T
A
D
R
M
E
A
D
L
V
P
K
H
G
I
E
I
D
F
I
R
I
S
--
G
--
L
-
R
--
G
--
K
------
G
---
I
--------------
K
-------
A
-----
L
----
I
A
----
A
-
P
---
L
R
--------
I
F
N
A
-
W
R
Q
A
R
A
I
M
K
A
Y
K
P
D
V
V
L
G
M
G
G-
Y
V
S
-
G
P
G
G
L
A
A
W
S
L
G
I
P
V
V
L
H
E
Q
N
G
I
A
---------------
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
-----------
N
-----------
K
---
W
---
L
----------
A
K
I
AT
K
V
M
Q
AFPGAFPN
A
E
V
V
G
N
P
V
R
T
D
V
L
A
L
P
L
---
P
Q
Q
R
L
A
G
--
R
---
E
G
P
V
-
R
V
L
V
V
G
G
S
Q
G
-------
A
---
R
---
I
L
N
Q
T
M
P
Q
V
A
A
K
--
L
G
D
S
V
T
I
W
H
Q
--
S
G
K
G
S
Q
-----
Q
S
V
E
Q
--
A
Y
-
A
E
-
A
G
Q
P
Q
H
K
V
T
E
F
I
D
D
M
A
A
A
Y
A
W
A
D
V
V
V
C
R
S
G
A
L
T
V
S
E
I
A
A
A
G
L
P
A
L
F
V
P
F
Q
H
K
-
D
R
Q
----
Q
Y
W
N
A
L
P
L
E
K
A
G
A
A
K
I
I
-
E
Q
P
Q
L
S
V
D
A
V
A
N
T
L
A
G
W
-
S
R
E
T
L
-
L
T
M
A
E
R
A
R
A
A
S
I
P
D
A
T
E
R
V
A
N
E
V
S
R
V
A
R
AL--
38
HHSearch
55.46
21%
-37
- C4 -
-
4M83
2
OLED_STRAT
A:
[8-395]
---------
A
H
I
A
M
F
S
I
A
A
H
G
H
V
N
P
S
L
E
V
I
R
E
L
V
A
R
G
H
R
V
T
Y
A
I
P
P
V
F
A
--
D
K
V
A
A
T
G
A
R
P
V
L
Y
H
S
T
--
L
PG
P
-
D
--
A
--
D
P-----
E
---
A
--------------
W
-------
G
ST
L
L
D
N
----
V
E
----
P
-
F
---
L
N
D
-------
A
I
Q
A
-
L
P
Q
L
A
D
A
Y
A
D
D
I
P
D
L
V
L
H
D
I
-
T
S
---
Y
P
A
R
V
L
A
R
R
W
G
V
P
A
V
S
L
S
P
N
L
V
A
---------------
W
---
K
----------------------
G
YEEEV
A
E
P
M
W
REPRQT
E
R
G
---
R
--------------------
A
Y
Y
--------------
A
R
--------------
F
-----------------
E
-----------------
A
W
L
K
E
------------
N
----
G
I
T
E
H
P
D
T
F
A
SHPP
R
S
L
V
L
I
-----------
P
---
K
---
A
LQPHADRVDE
D
V
---------------
Y
T
F
V
G
A
C
Q
G
D
R
A
E
E
---
G
----
G
W
Q
R
P
--
A
---
G
A
E
K
-
V
V
L
V
S
L
G
S
A
F
-------
T
---
K
QP-
A
F
Y
R
E
C
V
R
A
F
G
N
--
L
-
P
G
W
H
L
V
L
Q
--
I
G
R
K
V
T
-----
P
-
A
E
---
L
--
G
E
L
P
D
N
--
V
E
V
H
D
W
V
-
P
Q
L
A
I
L
R
Q
A
D
L
F
V
T
H
A
G
A
G
G
S
Q
E
G
L
A
T
A
T
P
M
I
A
V
P
Q
A
V
----
D
----
Q
F
G
N
A
D
M
L
Q
G
L
G
V
A
R
K
L
-
A
T
E
E
A
T
A
D
L
L
R
E
T
A
L
A
L
V
D
D
P
E
V
A
R
R
L
R
R
I
Q
A
E
M
A
Q
E
G
G
T
R
R
A
A
D
L
I
E
--------
30
HHSearch
55.37
21%
-40
- C4 -
-
2IYF
2
OLED_STRAT
B:
[6-395]
-------
T
P
A
H
I
A
M
F
S
I
A
A
H
G
H
V
N
P
S
L
E
V
I
R
E
L
V
A
R
G
H
R
V
T
Y
A
I
P
P
V
F
A
--
D
K
V
A
A
T
G
P
R
P
V
L
Y
H
S
T
LP
G
--
P
-
D
--
A
--
D
P-----
E
---
A
--------------
W
-------
G
S----
T
LLDN
V
E
----
P
-
F
---
L
N
D
-------
A
I
Q
A
-
L
P
Q
L
A
D
A
Y
A
D
D
I
P
D
L
V
L
H
D
I
-
T
S
---
Y
P
A
R
V
L
A
R
R
W
G
V
P
A
V
S
L
S
P
N
L
V
A
---------------
W
---
K
----------------------
G
----------------------
Y
EEEV
A
E
P
M
W
R
EPRQT
E
R
G
R
-
A
Y
Y
--------------
A
R
--------------
F
-----------------
E
-----------------
A
----------------
W
L
K
E
N
G
I
T
E
H
P
D
T
-----------
F
A
SHPP
R
S
L
V
LI
P
---
K
---
A
LQPHADRVDE
D
V
---------------
Y
T
F
V
G
A
C
Q
G
D
R
A
E
E
---
G
----
G
W
Q
R
P
--
A
---
G
A
E
K
-
V
V
L
V
S
L
G
S
A
F
-------
T
---
K
Q
P
-
A
F
Y
R
E
C
V
R
A
F
G
N
--
L
-
P
G
W
H
L
V
L
Q
--
I
G
R
K
V
T
-----
P
A
E
L
------
G
E
L
P
D
N
--
V
E
V
H
D
W
V
-
P
Q
L
A
I
L
R
Q
A
D
L
F
V
T
H
A
G
A
G
G
S
Q
E
G
L
A
T
A
T
P
M
I
A
V
P
Q
A
V
----
D
----
Q
F
G
N
A
D
M
L
Q
G
L
G
V
A
R
K
L
-
A
T
E
E
A
T
A
D
L
L
R
E
T
A
L
A
L
V
D
D
P
E
V
A
R
R
L
R
R
I
Q
A
E
M
A
Q
E
G
G
T
R
R
A
A
D
L
I
E
--------
37
HHSearch
54.74
16%
-60
- C4 -
-
4G2T
1
?
A:
[14-396]
--------
H
M
R
I
L
V
I
A
G
C
S
E
G
F
V
M
P
L
V
P
L
S
W
A
L
R
A
A
G
H
E
V
L
V
A
A
S
E
N
M
G
--
P
T
V
T
G
A
G
L
P
F
A
P
T
C
P
S
--
L
--
D
M
P
--
E
--
V
L
S
W
DRE
G
---
N
--------------
R
T
T
M
P
RE
E
K
-----
P
----
L
L
E
H
I
G
R
G
Y
---
G
R
L
-------
V
L
R
M
-
R
D
E
A
L
A
L
A
E
R
W
K
P
D
L
V
L
T
E
T
-
Y
S
---
L
T
G
P
L
V
A
A
T
L
G
I
P
W
I
E
Q
S
I
R
L
A
S
---------------
P
---
E
L
I
K
S
A
G
V
G
E
-------------
L
----------------------
A
--------------------
P
E
L
--------------
A
E
L
GLTDFP-------
D
-----------------
P
-----------------
L
----------------
L
----
S
I
D
V
C
P
P
S
-----------
M
EA--------------G--
T
----------
T
K
---------------
M
R
Y
V
P
Y
N
G
R
N
D
Q
V
P
---
S
----
W
V
F
-
E
--
E
---
R
K
Q
P
-
R
L
C
L
T
F
G
T
R
V
-------
P
---
L
----
L
L
Q
A
L
S
Q
E
L
P
K
--
L
--
G
F
E
V
V
V
A
---
V
S
D
K
L
-----
A
------------
P
E
G
--
V
L
A
A
G
Q
F
-
P
L
S
A
I
M
P
A
C
D
V
V
V
H
H
G
G
H
G
T
T
L
T
C
L
S
E
G
V
P
Q
V
S
V
P
V
I
A
----
E
----
V
W
D
S
A
R
L
L
H
A
A
G
A
G
V
E
V
-
P
-------
S
V
L
A
A
C
A
R
I
R
D
D
S
S
Y
V
G
N
A
R
R
L
A
A
E
M
A
T
L
P
T
P
A
D
I
V
R
L
I
E
Q
-------
34
HHSearch
52.17
17%
-19
- C4 -
-
3OTH
2
?
A:
[14-404]
--
G
H
I
E
G
R
H
M
R
V
L
F
A
S
L
G
T
H
G
H
T
Y
P
L
L
P
L
A
T
A
A
R
A
A
G
H
E
V
T
F
A
T
G
E
G
F
A
--
G
T
L
R
K
L
G
F
E
P
V
A
T
G
M
P
--
V
--
F
-
D
--
G
--
F
L
-----
A
A
L
R
I
R
FDTDSPEGLT
P
E
Q
L
-------
S
-----
E
----
L
P
----
Q
-
I
VFG
R
V
I
-------
P
Q
R
V
-
F
D
E
L
Q
P
V
I
E
R
L
R
P
D
L
V
V
Q
E
I
-
S
--
N
-
Y
G
A
G
L
A
A
L
K
A
G
I
P
T
I
C
H
G
V
G
R
D
T
---------------
P
---
D
D
L
T
R
S
I
E
E
E
-------------
V
----------------------
R
G
L
A
Q
----------------
R
L
G
--------------
L
D
--------------
L
-----------------
P
-----------------
P
----------------
G
----
R
I
D
G
F
G
N
P
F
I
D
I-------
F
-----------
P
---
P
---
S
LQE-------
P
E
---------------
F
R
A
R
P
R
R
H
E
L
R
P
V
P
F
A
E
Q
G
D
L
P
A
W
L
S
S
R-
D
---
T
A
R
P
-
L
V
Y
L
T
L
G
T
S
S
-------
G
---
G
T
V
-
E
V
L
R
A
A
I
D
G
L
A
G
--
L
--
D
A
D
V
L
V
A
--
S
G
P
S
L
D
-----
V
-
S
G
----
L
-
G
E
V
P
A
N
--
V
R
L
E
S
W
V
-
P
Q
A
A
L
L
P
H
V
D
L
V
V
H
H
G
G
S
G
T
T
L
G
A
L
G
A
G
V
P
Q
L
S
F
P
W
A
G
----
D
----
S
F
A
N
A
Q
A
V
A
Q
A
G
A
G
D
H
L
-
L
P
D
N
I
S
P
D
S
V
S
G
A
A
K
R
L
L
A
E
E
S
Y
R
A
G
A
R
A
V
A
A
E
I
A
A
M
P
G
P
D
E
V
V
R
L
L
P
--------
35
HHSearch
51.82
17%
-21
- C4 -
-
3OTG
1
?
A:
[18-404]
------
G
R
H
M
R
V
L
F
A
S
L
G
T
H
G
H
T
Y
P
L
L
P
L
A
T
A
A
R
A
A
G
H
E
V
T
F
A
T
G
E
G
F
A
--
G
T
L
R
K
L
G
F
E
P
V
A
T
G
M
P
--
V
--
F
-
D
--
G
--
F
L
-----
A
A
L
R
I
R
FDTDSPEGLT
P
E
Q
L
-------
S
-----
E
----
L
P
----
Q
-
I
V
F
G
R
V
I
-------
P
Q
R
V
-
F
D
E
L
Q
P
V
I
E
R
L
R
P
D
L
V
V
Q
E
I
-
S
--
N
-
Y
G
A
G
L
A
A
L
K
A
G
I
P
T
I
C
H
G
V
G
R
D
T
---------------
P
---
D
D
L
T
R
S
I
E
E
E
-------------
V
----------------------
R
G
L
A
Q
----------------
R
L
G
--------------
L
D
--------------
L
-----------------
P
-----------------
P
----------------
G
----
R
I
D
G
F
G
N
P
F
I
D
I-------
F
-----------
P
---
P
---
S
LQE-------
P
E
---------------
F
R
A
R
P
R
R
H
E
L
R
P
V
P
F
A
E
Q
G
D
L
P
A
W
L
S
S
R-
D
---
T
A
R
P
-
L
V
Y
L
T
L
G
T
S
S
-------
G
---
G
T
V
-
E
V
L
R
A
A
I
D
G
L
A
G
--
L
--
D
A
D
V
L
V
A
--
S
G
P
S
L
D
-----
V
-
S
G
----
L
-
G
E
V
P
A
N
--
V
R
L
E
S
W
V
-
P
Q
A
A
L
L
P
H
V
D
L
V
V
H
H
G
G
S
G
T
T
L
G
A
L
G
A
G
V
P
Q
L
S
F
P
W
A
G
----
D
----
S
F
A
N
A
Q
A
V
A
Q
A
G
A
G
D
H
L
-
L
P
D
N
I
S
P
D
S
V
S
G
A
A
K
R
L
L
A
E
E
S
Y
R
A
G
A
R
A
V
A
A
E
I
A
A
M
P
G
P
D
E
V
V
R
L
L
P
--------
42
HHSearch
51.63
16%
-37
- C4 -
-
5GL5
1
ATG26_YEAST
A:
[37-455]
------
N
K
S
Y
K
F
G
L
L
T
I
G
S
R
G
D
V
Q
P
Y
I
A
L
G
K
G
L
I
K
E
G
H
Q
V
V
I
I
T
H
S
E
F
-
R
-
D
F
V
E
S
H
G
I
Q
F
E
E
I
A
G
N
--
P
--
V
-
E
L
M
S
--
L
M
V
EN--
E
SM-
N
--------------
V
-------
K
-----
M
L
R
E
A
S
S
----
K
-
F
---
R
G
W
-------
I
D
A
L
-
L
Q
T
S
W
E
V
C
N
R
R
K
F
D
I
L
I
E
S
P
-
S
A
---
M
V
G
I
H
I
T
E
A
L
Q
I
P
Y
F
R
A
F
T
M
P
W
T
---------------
R
TRA
Y
PHAFIVPDQKRG
G
N
--------
Y
----------------------
N
Y
L
T
H
V
L
F
E
N
V
F
W
K
G
I
S
G
Q
V
N
K
W
R
--------------
V
E
TLGLGKTNLFLLQQ
N
-----------------
N
-----------------
V
----------------
P
----
F
L
Y
N
V
S
P
T
-----------
I
FP---------
P
---
S
I--
D
FS--------
E
W
---------------
V
R
V
T
G
Y
W
F
L
D
D
K
S
T
F
K
P
P
A
E
L
Q
E
F
I
S
E
A
R
S
---
K
G
K
K
-
L
V
Y
I
G
F
G
S
I
V
-------
V
---
S
N
A
K
E
M
T
E
A
L
V
E
A
V
M
E
--
A
--
D
V
Y
C
I
L
N
--
K
G
W
S
E
R
L----
G
----KK
T
E
-
V
D
L
P
R
N
--
I
L
N
I
G
N
V
-
P
H
D
W
L
F
P
Q
V
D
A
A
V
H
H
G
G
S
G
T
T
G
A
S
L
R
A
G
L
P
T
V
I
K
P
F
F
G
----
D
----
Q
F
F
Y
A
G
R
V
E
D
I
G
V
G
I
A
L
-
K
K
L
N
--
A
Q
T
L
A
D
A
L
K
V
A
T
T
N
K
I
M
K
D
R
A
G
L
I
K
K
K
I
S
K
E
D
G
I
K
T
A
I
S
A
I
---------
32
HHSearch
51.37
17%
-39
* C4 *
-
2IYA
2
?
A:
[11-417]
-------
T
P
R
H
I
S
F
F
N
I
P
G
H
G
H
V
N
P
S
L
G
I
V
Q
E
L
V
A
R
G
H
R
V
S
Y
A
I
T
D
E
F
A
--
A
Q
V
K
A
A
G
A
T
P
V
V
Y
D
S
I
--
L
--
P
-
K
--
E
--
S
NPE---
E
---
S
--------------
W
-------
P
ED
Q
E
-
S
----
A
M
G
---
L
-
F
---
L
D
E
-------
A
V
R
V
-
L
P
Q
L
E
D
A
Y
A
D
D
R
P
D
L
I
V
Y
D
I
-
A
S
---
W
P
A
P
V
L
G
R
K
W
D
I
P
F
V
Q
L
S
P
T
F
V
A
---------------
Y
---
E
----------------------
G
F
E
E
D
V
-----------------
P
AVQDPTA
E
D
G
L
V
--------
R
F
F
--------------
T
R
--------------
L
S
A
F
--------------
L
-----------------
E
E
H
GVDTP
A
T
E
F
L
IAPN
R
----
C
I
V
A
L
P
R
T
-----------
F
-----------
Q
IK-
G
D--
T
VG--------
D
N
---------------
Y
T
F
V
G
P
T
Y
G
D
R
S
H
Q
-------
G
T
W
E
G
P
--
G
---
D
G
R
P
-
V
L
L
I
A
L
G
S
A
F
-------
T
---
D
H
L
-
D
F
Y
R
T
C
L
S
A
V
D
G
--
L
--
D
W
H
V
V
L
S
--
V
G
R
F
V
D
-----
P
A
D
L
------
G
E
V
P
P
N
--
V
E
V
H
Q
W
V
P
Q
L
-
D
I
L
T
K
A
S
A
F
I
T
H
A
G
M
G
S
T
M
E
A
L
S
N
A
V
P
M
V
A
V
P
Q
I
A
----
E
----
Q
T
M
N
A
E
R
I
V
E
L
G
L
G
R
H
I
-
P
R
D
Q
V
T
A
E
K
L
R
E
A
V
L
A
V
A
S
D
P
G
V
A
E
R
L
A
A
V
R
Q
E
I
R
E
A
G
G
A
R
A
A
A
D
I
L
E
--------
41
HHSearch
50.89
14%
-61
- C4 -
-
4LEI
1
?
A:
[15-437]
-------
S
H
M
R
V
L
F
T
P
L
P
A
S
S
H
F
F
N
L
V
P
L
A
W
A
L
R
A
A
G
H
E
V
R
V
A
I
C
P
N
M
V
--
S
M
V
T
G
A
G
L
T
A
V
P
V
G
D
E
--
L
--
D
-
L
I-
S
--
L
---------------------------------------------------------
D
A
V
E
Q
L
H
LV
D
D
R
S
-
L
D
D
L
M
G
F
A
E
K
W
Q
P
D
L
V
V
W
D
A
-
M
V
---
C
S
G
P
V
V
A
R
A
L
G
A
R
H
V
R
M
L
V
A
L
D
V
S
G
W
L
R
S
G
F
L
E
Y
Q
E
S
K
P
---
P
EQR-------------------
V
----------------------
D
P
L
G
-----------------
T
W
L
--------------
G
A
--------------
K
L
A
KFG
A
T
----------
F
-----------------
D
----------------
E
----
E
I
V
T
G
Q
A
T
I
D
P--------
I
-----------
P
---
S
---
W
MR
L
P
------
V
D
---------------
L
D
Y
I
S
M
R
F
V
P
Y
N
G
P
---
A
-
V
L
P
E
W
L
R
E
--
R
---
P
T
K
P
-
R
V
C
I
T
R
G
L
T
K
RRLSRVE
Q
---
A
---
M
V
-
E
R
L
L
R
G
A
A
R
--
L
--
D
V
E
V
I
A
T
--
L
S
D
D
E
V
----------------
E
L
P
S
N
--
V
R
V
H
E
Y
V
-
P
L
N
E
L
L
E
S
C
S
V
I
I
H
H
G
S
T
T
T
Q
E
T
A
T
V
N
G
V
P
Q
L
I
L
P
------
W
D
----
E
S
R
R
A
E
L
L
A
D
R
G
A
G
L
V
L
-
D
P
A
T
F
T
E
D
D
V
R
G
Q
L
A
R
L
L
D
E
P
S
F
A
A
N
A
A
L
I
R
R
E
I
E
E
S
P
S
P
H
D
I
V
P
R
L
E
--------
28
HHSearch
47.79
13%
-31
- C4 -
-
3RSC
2
?
B:
[19-409]
-------
H
M
A
H
L
L
I
V
N
V
A
S
H
G
L
I
L
P
T
L
T
V
V
T
E
L
V
R
R
G
H
R
V
S
Y
V
T
A
G
G
F
A
--
E
P
V
R
A
A
G
A
T
V
V
P
Y
Q
S
E
--
I
--
I
-
D
--
A
D-
A
------
A
---
E
VFGSDD--------
L
-------
G
VRP--
H
----
L
M
----
Y
-
L
---
R
E
--------
N
V
S
V
-
L
R
A
T
A
E
A
L
D
G
D
V
P
D
L
V
L
Y
D
D
-
F
P
F
I
-
A
-
G
Q
L
L
A
A
R
W
R
R
P
A
V
R
L
S
A
A
F
A
S
---------------
N
---
E
----------------------
H
YSFSQDMVTLAGTIDPLDLPVF
R
--------------------
D
T
L
--------------
R
D
--------------
L
LAEHGLSRSVVDCWNHV
E
-----------------
Q
----------------
L
----
N
L
V
F
V
P
K
A
-----------
F
-----------
Q
IA-
G
DTF
D
----------
D
R
---------------
F
V
F
V
G
P
C
F
D
D
R
R
F
L
---
G
----
E
W
T
R
P
--
A
---
D
D
L
P
-
V
V
L
V
S
L
G
T
T
F
-------
N
DRP
G
---
F
F
R
D
C
A
R
-
A
F
D
G
--
Q
--
P
W
H
V
V
M
T
--
L
G
G
Q
V
D
-----
P
-
A
A
----
L
-
G
D
L
P
P
N
--
V
E
A
H
R
W
V
-
P
H
V
K
V
L
E
Q
A
T
V
C
V
T
H
G
G
M
G
T
L
M
E
A
L
Y
W
G
R
P
L
V
V
V
P
Q
S
----
F
D
----
V
Q
P
M
A
R
R
V
D
Q
L
G
L
G
A
V
L
-
P
G
E
K
A
D
G
D
T
L
L
A
A
V
G
A
V
A
A
D
P
A
L
L
A
R
V
E
A
M
R
G
H
V
R
R
A
G
G
A
A
R
A
A
D
A
V
E
--------
51
Fugue
47.17
20%
-23
- C4 -
-
4X1T
10
MGDG1_ARATH
A:
[6-389]
--------
K
K
V
L
I
L
M
S
D
T
G
G
G
H
R
A
S
A
E
A
I
R
A
A
F
N
Q
E
F
----------
G
D
E
Y
Q
V
F
I
T
Q
P
--------------------------------------------------------------------------------
D
--------
I
I
I
S
-
V
H
P
L
M
Q
H
V
P
L
R
V
L
R
S
-------------
K
G
L
L
K
K
I
V
F
T
T
V
I
T
D
L
S
T
C
H
P
---------------
T
---
W
----------------------
F
----------------------
H
--------------------
K
L
V
--------------
T
R
--------------
C
Y
C
P--------------
S
-----------------
T
----------------
E
----
V
A
K
R
A
Q
K
A
-----------
G
-----------
L
---
E
---
T
----------
S
Q
---------------
I
K
V
Y
G
L
P
V
R
P
S
F
V
K
P
V
R
P
K
V
E
L
R
R
E
L
G
--
M
---
D
E
N
L
P
A
V
L
L
M
G
G
G
E
G
-------
M
---
G
---
P
I
E
A
T
A
R
-
A
L
A
D
--
A
L
Y
D
K
N
L
G
E
A
--
V
G
Q
V
L
I
I
CGRN
K
K
L
Q
S
--
K
L
-
S
S
L
D
W
K
I
P
V
Q
V
K
G
F
I
T
K
M
E
E
C
M
G
A
C
D
C
I
I
T
K
A
G
P
G
T
I
A
E
A
M
I
R
G
-------
L
P
I
I
L
N
G
Y
IAGQ
E
A
G
N
V
P
Y
V
V
E
N
G
C
G
K
F
S
-
K
S
P
K
E
I
S
K
I
V
A
D
W
F
G
P
--
A
S
K
E
L
-
E
I
M
S
Q
N
A
L
R
L
A
K
P
E
A
V
F
K
I
V
H
D
M
H
E
L
V
R
K
K
N
S
31
HHSearch
46.79
16%
-51
- C4 -
-
1RRV
4
GTFD_AMYOR
A:
[1-396]
---------
M
R
V
L
L
S
V
C
G
T
R
G
D
V
E
I
G
V
A
L
A
D
R
L
K
A
L
G
V
Q
T
R
M
C
A
P
P
A
A
-
E
-
E
R
L
A
E
V
G
V
P
H
V
P
V
G
L
P
--
Q
--
H
-
M
--
M
L-
Q
------
E
---
G
--------------
M
-------
P
PPP
P
E
E
----
E
Q
----
R
-
L
---
A
A
M
T
------
V
E
M
Q
-
F
D
A
V
P
G
A
A
E
G
C
A
A
V
V
A
V
G
D
L
-
A
A
A
--
T
G
V
R
S
V
A
E
K
L
G
L
P
F
F
Y
S
V
P
S
P
V
Y
---------------
L
---
A
----------------------
S
PHLPPAYDEPTTPGVTD
I
R
---
V
--------------------
L
W
E
E
R
A
A
R
F
A
D
R
Y
G
P
T
L
N
R
--------------
R
R
A
E
I
GLPPVED
V
F
G
Y
G
H
G
-----------------
E
----------------
R
----
P
L
L
A
A
D
P
V
-----------
L
-----------
A
PLQ
P
---
D
----------
V
D
---------------
A
V
Q
T
G
A
W
L
L
S
D
E
R
P
L
P
-
P
-
E
L
E
A
F
--
L
--
A
---
A
G
S
P
-
P
V
H
I
G
F
G
S
S
S
GR
G
----
I
---
A
---
D
A
A
K
V
A
V
E
A
I
R
A
--
Q
--
G
R
R
V
I
L
S
--
R
G
W
T
E
L
-----
V
--
L
------
P
D
D
R
D
D
--
C
F
A
I
D
E
V
-
N
F
Q
A
L
F
R
R
V
A
A
V
I
H
H
G
S
A
G
T
E
H
V
A
T
R
A
G
V
P
Q
L
V
I
P
R
N
T
----
D
----
Q
P
Y
F
A
G
R
V
A
A
L
G
I
G
V
A
H
-
D
G
P
T
P
T
F
E
S
L
S
A
A
L
T
T
V
L
A
-
P
E
T
R
A
R
A
E
A
V
A
G
M
V
L
T
-
D
G
A
A
A
A
A
D
L
V
L
--------
39
HHSearch
46.77
16%
-45
- C4 -
-
1IIR
-
GTFB_AMYOR
A:
[1-395]
---------
M
R
V
L
L
A
T
C
G
S
R
G
D
T
E
P
L
V
A
L
A
V
R
V
R
D
L
G
A
D
V
R
M
C
A
P
P
D
C
-
A
E
-
R
L
A
E
V
G
V
P
H
V
P
V
G
P
-----------
R
A
K
P
------
L
---
T
--------------
A
-------
E
-----
D
----
V
R
R
---
F
-
T
---
T
E
--------
A
I
A
T
Q
F
D
E
I
P
A
A
A
E
--
G
C
A
A
V
V
T
T
G
-
L
L
A
A
A
I
G
V
R
S
V
A
E
K
L
G
I
P
Y
F
Y
A
F
H
C
P
S
Y
---------------
V
---
P
SPYYPPPPI
D
I
P
A
Q
W
E
R
N
N
Q
S
A
Y
Q
R
Y-------------------
G
--------------------
G
L
L
--------------
N
S
--------------
H
-----------------
R
D
A
I
GLPPVED
I
F
T
F
G
Y
T
D
----------------
H
----
P
W
V
A
A
D
P
V
-----------
L
-----------
A
P
L
Q
P
T--
D
----------
L
D
---------------
A
V
Q
T
G
A
W
I
L
P
D
E
R
P
L
S
-
P
-
E
L
A
A
F
--
L
--
D
---
A
G
P
P
-
P
V
Y
L
G
F
G
--
A
-------
P
A
--
D
---
A
V
R
V
A
I
-
D
A
I
R
A
--
H
--
G
R
R
V
I
L
S
--
R
G
W
A
D
------
L
-
V
L
------
P
D
D
G
A
D
--
C
F
A
I
G
E
V
-
N
H
Q
V
L
F
G
R
V
A
A
V
I
H
H
G
G
A
G
T
T
H
V
A
A
R
A
G
A
P
Q
I
L
L
P
Q
M
A
----
D
----
Q
P
Y
Y
A
G
R
V
A
E
L
G
V
G
V
A
H
-
D
G
P
I
P
T
F
D
S
L
S
A
A
L
A
T
A
L
T
P
E
T
H
-
A
R
A
T
A
V
A
G
T
I
R
T
-
D
G
A
A
V
A
A
R
L
L
L
--------