@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VP00: (2017-11-19 )
MRVLVIMDPIETVNLKKDSTMAMLWAASRRGHELGYALQQDLYIDQGKAYGLISPLKVFEDYNHYYELGEKKKESIAAYDVVLMRKDPPFDMNFVYTTYVLEQAEREGSWIINKPQSLRDCNEKLFATQFPELQVPTLVTSQQSLIREFITEHGDVIVKPLDGMGGMGIFRLYQDGVNIGSTLEMLTELGTRPIMAQRYIPEIVEGDKRILMVNGEPIPYCLARIPQNGEVRGNLAAGGLGQARPLTENDKLIAAKVGPFLREKGLVFVGLDVIGNYVTEINVTSPTCIREIDAQFGTSIADDLFDVLEAGRPA
Atome Classification :
(20 SA)
--.........10.....-...20........30........40........50........60........70........80........90........100.......110-.......120.......-------130----..----..-...140..-------.....150-.-..--....160.......170.......180......----.----190.......200.......210.......220.......230...---....--240--.----......250.......260.......270..----..-----...280.......290---.........300.......310..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--
M
R
V
L
V
I
MDPI
E
T
VNLK-KDS
T
M
A
M
L
W
AASRRGHE
L
G
Y
A
L
Q
Q
D
L
Y
IDQGKAYGLI
S
P
L
K
V
F
E
D
Y
N
H
Y
Y
E
L
G
E
K
K
K
E
SIA
A
Y
D
V
V
L
MRKDPPFD
M
N
F
V
Y
T
T
Y
V
L
E
Q
AEREG
S
W
I
I-NK
P
Q
S
L
R
D
C
N
E
K
L
F
ATQ-------FPE----LQ----VP-TLVT
S
Q
Q
S
-------
L
I
R
E
F
I
T
E-H-G
D
--
V
I
V
K
PLDGMG
G
M
G
I
F
R
L
Y
QDGVNI
G
S
T
L
E
M
L
T
E----L----GTRP
I
M
A
Q
R
Y
I
P
E
I
VEGD
K
R
I
L
M
VNGEP
I
P
Y
C
L
A
RIPQNGEVRGNL---AAGG--LGQ--A----RPLTEND
K
L
I
A
AKV
G
P
F
L
R
EK
G
L
V
F
V
G
L
D
V
I----GN-----Y
V
T
E
I
NVTS
P
T
C
I
R
-----
E
I
D
A
Q
FGT
S
I
A
D
D
L
F
D
V
L
EAGRPA
1
PsiBlast_PDB
93.55
55%
-104
- C3 -
-
1GSA
1
GSHB_ECOLI
A:
[2-311]
--
I
K
L
G
I
V
M
D
P
I
A
N
I
N
I
K
-
K
D
S
S
F
A
M
L
L
E
A
Q
R
R
G
Y
E
L
H
Y
M
E
M
G
D
L
Y
L
I
N
G
E
A
R
A
H
T
R
T
L
N
V
K
Q
N
Y
E
E
W
F
S
F
V
G
E
Q
D
L
P
L
A
D
L
D
V
I
L
M
R
K
D
P
P
F
D
T
E
F
I
Y
A
T
Y
I
L
E
R
A
E
E
K
G
T
L
I
V
-
N
K
P
Q
S
L
R
D
C
N
E
K
L
F
T
A
W
-------
F
S
D
----
L
T
----
P
E
-
T
L
V
T
R
N
K
A
-------
Q
L
K
A
F
W
E
K
-
H
-
S
D
--
I
I
L
K
P
L
D
G
M
G
G
A
S
I
F
R
V
K
E
G
D
P
N
L
G
V
I
A
E
T
L
T
E
----
H
----
G
T
R
Y
C
M
A
Q
N
Y
L
P
A
I
K
D
G
D
K
R
V
L
V
V
D
G
E
P
V
P
Y
C
L
A
R
I
P
Q
G
G
E
T
R
G
N
L
---
A
A
G
G
--
R
G
E
--
P
----
R
P
L
T
E
S
D
W
K
I
A
R
Q
I
G
P
T
L
K
E
K
G
L
I
F
V
G
L
D
I
I
----
G
D
-----
R
L
T
E
I
N
V
T
S
P
T
C
I
R
-----
E
I
E
A
E
F
P
V
S
I
T
G
M
L
M
D
A
I
E
A
----
36
HHSearch
89.90
53%
-45
- C3 -
-
1GSA
1
GSHB_ECOLI
A:
[2-314]
--
I
K
L
G
I
V
M
D
P
I
A
N
I
N
I
K
-
K
D
S
S
F
A
M
L
L
E
A
Q
R
R
G
Y
E
L
H
Y
M
E
M
G
D
L
Y
L
I
N
G
E
A
R
A
H
T
R
T
L
N
V
K
Q
N
Y
E
E
W
F
S
F
V
G
E
Q
D
L
P
L
A
D
L
D
V
I
L
M
R
K
D
P
P
F
D
T
E
F
I
Y
A
T
Y
I
L
E
R
A
E
E
K
G
T
L
I
V
-
N
K
P
Q
S
L
R
D
C
N
E
K
L
F
T
A
W
-------
F
S
D
----
L
T
----
P
E
-
T
L
V
T
R
N
K
A
-------
Q
L
K
A
F
W
E
K
-
H
-
S
D
--
I
I
L
K
P
L
D
G
M
G
G
A
S
I
F
R
V
K
E
G
D
P
-
N
L
G
V
I
A
E
T
L
T
E
H--
G
----
T
-
R
Y
C
M
A
Q
N
Y
L
P
A
I
K
D
G
D
K
R
V
L
V
V
D
G
E
P
V
P
Y
C
L
A
R
I
P
Q
G
G
E
T
R
G
N
L
---
A
A
G
G
--
R
G
E
--
P
----
R
P
L
T
E
S
D
W
K
I
A
R
Q
I
G
P
T
L
K
E
K
G
L
I
F
V
G
L
D
I
I
----
G
D
-----
R
L
T
E
I
N
V
T
S
P
T
C
I
R
-----
E
I
E
A
E
F
P
V
S
I
T
G
M
L
M
D
A
I
E
A
R
L
Q
-
2
PsiBlast_PDB
88.66
55%
-126
- C3 -
-
1GSH
-
GSHB_ECOLI
A:
[2-311]
--
I
K
L
G
I
V
M
D
P
I
A
N
I
N
I
K
-
K
D
S
S
F
A
M
L
L
E
A
Q
R
R
G
Y
E
L
H
Y
M
E
M
G
D
L
Y
L
I
N
G
E
A
R
A
H
T
R
T
L
N
V
K
Q
N
Y
E
E
W
F
S
F
V
G
E
Q
D
L
P
L
A
D
L
D
V
I
L
M
R
K
D
P
P
F
D
T
E
F
I
Y
A
T
Y
I
L
E
R
A
E
E
K
G
T
L
I
V
-
N
K
P
Q
S
L
R
D
C
N
E
K
L
F
T
A
W
-------
F
S
D
----
L
T
----
P
E
-
T
L
V
T
R
N
K
A
-------
Q
L
K
A
F
W
E
K
-
H
-
S
D
--
I
I
L
K
P
L
D
----
A
S
I
F
R
V
K
E
G
D
P
N
L
G
V
I
A
E
T
L
T
E
----
H
----
G
T
R
Y
C
M
A
Q
N
Y
L
P
A
I
K
D
G
D
K
R
V
L
V
V
D
G
E
P
V
P
Y
C
L
A
---------------------
R
G
E
--
P
----
R
P
L
T
E
S
D
W
K
I
A
R
Q
I
G
P
T
L
K
E
K
G
L
I
F
V
G
L
D
I
I
----
G
D
-----
R
L
T
E
I
N
V
T
S
P
T
C
I
R
-----
E
I
E
A
E
F
P
V
S
I
T
G
M
L
M
D
A
I
E
A
----
3
PsiBlast_PDB
86.97
55%
-127
- C3 -
-
2GLT
-
GSHB_ECOLI
A:
[2-311]
--
I
K
L
G
I
V
M
D
P
I
A
N
I
N
I
K
-
K
D
S
S
F
A
M
L
L
E
A
Q
R
R
G
Y
E
L
H
Y
M
E
M
G
D
L
Y
L
I
N
G
E
A
R
A
H
T
R
T
L
N
V
K
Q
N
Y
E
E
W
F
S
F
V
G
E
Q
D
L
P
L
A
D
L
D
V
I
L
M
R
K
D
P
P
F
D
T
E
F
I
Y
A
T
Y
I
L
E
R
A
E
E
K
G
T
L
I
V
-
N
K
P
Q
S
L
R
D
C
N
E
K
L
F
T
A
W
-------
F
S
D
----
L
T
----
P
E
-
T
L
V
T
R
N
K
A
-------
Q
L
K
A
F
W
E
K
-
H
-
S
D
--
I
I
L
K
P
L
D
----
A
S
I
F
R
V
K
E
G
D
P
N
L
G
V
I
A
E
T
L
T
E
----
H
----
G
T
R
Y
C
M
A
Q
N
Y
L
P
A
I
K
D
G
D
K
R
V
L
V
V
D
G
E
P
V
P
Y
C
L
A
---------------------
R
G
E
--
P
----
R
P
L
T
E
S
D
W
K
I
A
R
Q
I
G
P
T
L
K
E
K
G
L
I
F
V
G
L
D
I
I
----
G
D
-----
R
L
T
E
I
N
V
T
S
P
T
C
I
R
-----
E
I
E
A
E
F
P
V
S
I
T
G
M
L
M
D
A
I
E
A
----
4
PsiBlast_PDB
85.82
51%
-120
- C3 -
-
1GLV
-
GSHB_ECOLI
A:
[2-311]
--
I
K
L
G
I
V
M
D
P
I
A
N
I
N
I
K
-
K
D
S
S
F
A
M
L
L
E
A
Q
R
R
G
Y
E
L
H
Y
M
E
M
G
D
L
Y
L
I
N
G
E
A
R
A
H
T
R
T
L
N
V
K
Q
N
Y
E
E
W
F
S
F
V
G
E
Q
D
L
P
L
A
D
L
D
V
I
L
M
R
K
D
P
P
F
D
T
E
F
I
Y
A
T
Y
I
L
E
R
A
E
E
K
G
T
L
I
V
-
N
K
P
Q
S
L
R
D
C
N
E
K
L
F
T
A
W
-------
F
S
D
----
L
T
----
P
E
-
T
L
V
T
R
N
K
A
-------
Q
L
K
A
F
W
E
K
-
H
-
S
D
--
I
I
L
K
P
L
D
----
A
S
I
F
R
V
K
E
G
D
P
N
L
G
V
I
A
E
T
L
T
E
----
H
----
G
T
R
Y
C
M
A
Q
N
Y
L
P
A
I
K
D
G
D
K
R
V
L
V
V
D
G
E
P
V
P
Y
C
L
A
R
----------------
G
G
--
G
G
E
--
P
----
R
P
L
T
E
S
D
W
K
I
A
R
Q
I
G
P
T
L
K
E
K
G
L
I
F
V
G
L
D
I
I
----
G
D
-----
R
L
T
E
I
N
V
T
S
P
T
C
I
R
-----
E
I
E
A
E
F
P
V
S
I
T
G
M
L
M
D
A
I
E
A
----
57
Fugue
73.76
59%
-99
- C3 -
-
1GSA
1
?
?:
[123-314]
-----------------------------------------------------------------------------------------------------------------------------
N
E
K
L
F
T
A
W
-------
F
S
D
----
L
T
----
P
E
-
T
L
V
T
R
N
K
A
-------
Q
L
K
A
F
W
E
K
-
H
-
S
D
--
I
I
L
K
P
L
D
G
M
G
G
A
S
I
F
R
V
K
E
G
D
P
N
L
G
V
I
A
E
T
L
T
E
----
H
----
G
T
R
Y
C
M
A
Q
N
Y
L
P
A
I
K
D
G
D
K
R
V
L
V
V
D
G
E
P
V
P
Y
C
L
A
R
I
P
Q
G
G
E
T
R
G
N
L
---
A
A
G
G
--
R
G
E
--
P
----
R
P
L
T
E
S
D
W
K
I
A
R
Q
I
G
P
T
L
K
E
K
G
L
I
F
V
G
L
D
I
I
----
G
D
-----
R
L
T
E
I
N
V
T
S
P
T
C
I
R
-----
E
I
E
A
E
F
P
V
S
I
T
G
M
L
M
D
A
I
E
A
R
L
Q
-
42
HHSearch
60.01
24%
-11
- C3 -
-
4IWY
2
RIMK_ECOLI
A:
[21-309]
--
M
K
I
A
I
L
S
R
D
G
T
------
L
Y
S
C
K
R
L
R
E
A
A
I
Q
R
G
H
L
V
E
I
L
D
P
L
S
C
Y
M
N
I
N
P
A
A
S
S
I
-----------
H
Y
K
-----
G
R
K
L
P
H
F
D
A
V
I
P
R
I
G
T
A
I
T
F
---
Y
G
T
A
A
L
R
Q
F
E
M
L
G
S
Y
P
L
-
N
E
S
V
A
I
A
R
A
R
D
K
L
R
S
M
Q
-------
L
L
A
R
Q
GI
D
L
----
P
V
-
T
G
I
A
H
S
P
D
-------
D
T
S
D
L
I
D
M
V
G
G
A
P
--
L
V
V
K
L
V
E
G
T
Q
G
I
G
V
V
L
A
E
T
R
Q
A
-
A
E
S
V
I
D
A
F
R
G
----
L
----
N
-
A
H
I
L
V
Q
E
Y
I
K
E
A
Q
G
C
D
I
R
C
L
V
V
G
D
E
V
V
A
-
A
I
E
R
R
A
K
E
G
D
F
R
S
N
L
---
H
R
G
G
--
A
A
S
--
V
----
A
S
I
T
P
Q
E
R
E
I
A
I
K
A
A
R
T
M
---
A
L
D
V
A
G
V
D
I
L
----
R
A
NRGP-
L
V
M
E
V
N
A
S
-
P
G
-
L
E
-----
G
I
E
K
T
T
G
I
D
I
A
G
K
M
I
R
W
I
E
R
H
---
41
HHSearch
59.91
24%
-12
- C3 -
-
4IWX
2
RIMK_ECOLI
A:
[21-309]
--
M
K
I
A
I
L
S
R
D
G
T
------
L
Y
S
C
K
R
L
R
E
A
A
I
Q
R
G
H
L
V
E
I
L
D
P
L
S
C
Y
M
N
I
N
P
A
A
S
S
I
-----------
H
Y
K
-----
G
R
K
L
P
H
F
D
A
V
I
P
R
I
G
T
A
I
T
F
---
Y
G
T
A
A
L
R
Q
F
E
M
L
G
S
Y
P
L
-
N
E
S
V
A
I
A
R
A
R
D
K
L
R
S
M
Q
-------
L
L
A
R
Q
GI
D
L
----
P
V
-
T
G
I
A
H
S
P
D
-------
D
T
S
D
L
I
D
M
V
G
G
A
P
--
L
V
V
K
L
V
E
G
T
Q
G
I
G
V
V
L
A
E
T
R
Q
A
-
A
E
S
V
I
D
A
F
R
G
----
L
----
N
-
A
H
I
L
V
Q
E
Y
I
K
E
A
Q
G
C
D
I
R
C
L
V
V
G
D
E
V
V
A
-
A
I
E
R
R
A
K
E
G
D
F
R
S
N
L
---
H
R
G
G
--
A
A
S
--
V
----
A
S
I
T
P
Q
E
R
E
I
A
I
K
A
A
R
T
M
---
A
L
D
V
A
G
V
D
I
L
----
R
A
NRGP-
L
V
M
E
V
N
A
S
-
P
G
-
L
E
-----
G
I
E
K
T
T
G
I
D
I
A
G
K
M
I
R
W
I
E
R
H
---
59
Fugue
58.09
24%
3
- C3 -
-
4IWX
2
RIMK_ECOLI
A:
[19-312]
S
H
M
K
I
A
I
L
-----
S
R
D
G
T
-
L
Y
S
C
K
R
L
R
E
A
A
I
Q
R
G
H
L
V
E
I
L
D
P
L
S
C
Y
M
N
I
N
P
A
A
S
S
I
H
Y
----------------
K
G
R
K
L
P
H
F
D
A
V
I
P
R
I
G
T
A
---
I
T
F
Y
G
T
A
A
L
R
Q
F
E
M
L
G
S
Y
P
L
-
N
E
S
V
A
I
A
R
A
R
D
K
L
R
S
M
Q
-------
L
L
A
----
R
Q
GIDL
P
V
-
T
G
I
A
H
S
P
D
-------
D
T
S
D
L
I
D
M
-
V
-
G
G
A
P
L
V
V
K
L
V
E
G
T
Q
G
I
G
V
V
L
A
-
E
T
R
Q
A
A
E
S
V
I
D
A
F
R
G
----
L
----
N
A
H
-
I
L
V
Q
E
Y
I
K
E
A
Q
G
C
D
I
R
C
L
V
V
-
G
D
E
V
V
A
A
I
E
R
R
A
K
E
G
D
F
R
S
N
L
---
H
R
G
G
--
A
A
S
--
V
----
A
S
I
T
P
Q
E
R
E
I
A
I
K
A
A
R
T
M
---
A
L
D
V
A
G
V
D
I
L
R
A
NR
G
P
-----
L
V
M
E
V
N
--
A
S
P
G
L
E
-----
G
I
E
K
T
T
G
I
D
I
A
G
K
M
I
R
W
I
E
R
H
A
T
T
38
HHSearch
57.17
19%
-27
- C3 -
-
3VPC
1
ARGX_SULTO
B:
[1-281]
--
M
R
V
V
L
I
V
D
I
V
-------
R
Q
E
E
K
L
I
A
K
A
L
E
E
N
K
V
Q
Y
D
I
I
N
V
A
Q
E
P
L
P
F
N
--------------------------
K
A
L
G
R
Y
D
V
A
I
I
R
P
V
S
M
Y
-----
R
A
L
Y
S
S
A
V
L
E
A
A
G
V
H
T
I
-
N
S
S
D
V
I
N
V
C
G
D
K
I
L
T
Y
S
-------
K
L
Y
R
E
GI
P
I
----
P
D
-
S
I
I
A
L
S
A
E
-------
A
A
L
K
A
Y
E
Q
-
R
G
F
P
--
L
I
D
K
P
P
I
G
S
W
G
R
L
V
S
L
I
R
D
V
F
E
-
G
K
T
I
I
E
H
R
E
L
MGNS
A
----
L
-
K
A
H
I
V
Q
E
Y
I
Q
Y
K
-
G
R
D
I
R
C
I
A
I
G
E
E
L
L
G
-
C
Y
A
R
N
I
P
P
N
E
W
R
A
N
V
---
A
L
G
G
--
T
P
S
--
N
----
I
E
V
D
E
K
L
K
E
T
V
V
K
A
V
S
I
V
---
H
G
E
F
V
S
I
D
I
L
----
E
H
P
N
KGY
V
V
N
E
L
N
D
V
-
P
E
-
F
K
-----
G
F
M
V
A
T
N
I
N
V
A
Q
K
L
V
E
Y
I
K
E
N
Y
S
-
37
HHSearch
56.67
19%
-23
- C3 -
-
3VPB
2
ARGX_SULTO
D:
[1-281]
--
M
R
V
V
L
I
V
D
I
V
-------
R
Q
E
E
K
L
I
A
K
A
L
E
E
N
K
V
Q
Y
D
I
I
N
V
A
Q
E
P
L
P
F
N
--------------------------
K
A
L
G
R
Y
D
V
A
I
I
R
P
V
S
M
Y
-----
R
A
L
Y
S
S
A
V
L
E
A
A
G
V
H
T
I
-
N
S
S
D
V
I
N
V
C
G
D
K
I
L
T
Y
S
-------
K
L
Y
REGI
P
I
----
P
D
-
S
I
I
A
L
S
A
E
-------
A
A
L
K
A
Y
E
Q
-
R
G
F
P
--
L
I
D
K
P
P
I
G
S
W
G
R
L
V
S
L
I
R
D
V
F
E
-
G
K
T
I
I
E
H
R
E
L
MGNS
A
----
L
-
K
A
H
I
V
Q
E
Y
I
Q
Y
K
-
G
R
D
I
R
C
I
A
I
G
E
E
L
L
G
-
C
Y
A
R
N
I
P
P
N
E
W
R
A
N
V
---
A
L
G
G
--
T
P
S
--
N
----
I
E
V
D
E
K
L
K
E
T
V
V
K
A
V
S
I
V
---
H
G
E
F
V
S
I
D
I
L
----
E
H
PNKGY
V
V
N
E
L
N
D
V
-
P
E
-
F
K
-----
G
F
M
V
A
T
N
I
N
V
A
Q
K
L
V
E
Y
I
K
E
N
Y
S
-
6
PsiBlast_PDB
54.76
24%
22
- C3 -
-
4IWX
2
RIMK_ECOLI
A:
[39-307]
------------------------------------------
R
E
A
A
I
Q
R
G
H
L
V
E
I
L
D
P
L
S
C
Y
M
N
I
N
P
A
A
S
S
I
H
Y
K
G
R
K
L
P
H
F
D
A
V
I
P
R
I
G
T
A
I
T
F
---
Y
G
T
A
A
L
R
Q
F
E
M
L
G
S
Y
P
L
-
N
E
S
V
A
I
A
R
A
R
D
K
L
R
S
M
Q
-------
L
L
A
----
R
Q
GID-
L
P
V
T
G
I
A
H
S
P
D
-------
D
T
S
D
L
I
D
M
-
V
-
G
G
A
P
L
V
V
K
L
V
E
G
T
Q
G
I
G
V
V
-
L
A
E
T
R
Q
A
A
E
S
V
I
D
A
F
R
G
----
L
----
N
A
H
-
I
L
V
Q
E
Y
I
K
E
A
Q
G
C
D
I
R
C
L
V
V
-
G
D
E
V
V
A
A
I
E
R
R
A
K
E
G
D
F
R
S
N
L
---
H
R
G
G
--
A
A
S
--
V
----
A
S
I
T
P
Q
E
R
E
I
A
I
K
A
A
---
R
T
M
A
L
D
V
A
G
V
D
I
L
R
A
NR
G
P
-----
L
V
M
E
V
N
-
A
S
P
G
-
L
E
-----
G
I
E
K
T
T
G
I
D
I
A
G
K
M
I
R
W
I
E
-----
39
HHSearch
52.39
18%
-34
- C3 -
-
3VPD
3
LYSX_THET8
A:
[1-280]
---
M
L
A
I
L
Y
D
R
---
I
----
R
P
D
E
R
M
L
F
E
R
A
E
A
L
G
L
P
Y
K
K
V
Y
V
P
A
L
P
M
V
L
G
----------------
E
R
P
E
-------
A
L
E
G
V
T
V
A
L
E
R
C
V
S
Q
S
-----
R
G
L
A
A
A
R
Y
L
T
A
L
G
I
P
V
V
-
N
R
P
E
V
I
E
A
C
G
D
K
W
A
T
S
V
-------
A
L
A
K
A
G
L
P
Q
----
P
K
-
T
A
L
A
T
D
R
E
-------
E
A
L
R
L
M
E
A
-
F
G
Y
P
--
V
V
L
K
P
V
I
G
S
W
G
R
L
L
A
K
V
T
D
R
A
A
-
A
E
A
L
L
E
H
K
E
V
LGGF
Q
----
H
-
Q
L
F
Y
I
Q
E
Y
V
E
K
P
-
G
R
D
I
R
V
F
V
V
G
E
R
A
I
A
-
A
I
Y
R
R
S
--
A
H
W
I
T
N
T
---
A
R
G
G
--
Q
A
E
--
N
----
C
P
L
T
E
E
I
A
R
L
S
V
G
A
A
E
A
V
---
G
G
G
V
V
A
V
D
L
F
----
E
S
ER
G
L
-
L
V
N
E
V
N
H
T
-
M
E
-
F
K
-----
N
S
V
H
T
T
G
V
D
I
P
G
E
I
L
R
Y
A
W
E
V
A
R
-
5
PsiBlast_PDB
50.31
24%
5
- C3 -
-
4IWY
2
RIMK_ECOLI
A:
[39-284]
------------------------------------------
R
E
A
A
I
Q
R
G
H
L
V
E
I
L
D
P
L
S
C
Y
M
N
I
N
P
A
A
S
S
I
H
Y
K
G
R
K
L
P
H
F
D
A
V
I
P
R
I
G
T
A
I
T
F
---
Y
G
T
A
A
L
R
Q
F
E
M
L
G
S
Y
P
L
-
N
E
S
V
A
I
A
R
A
R
D
K
L
R
S
M
Q
-------
L
L
A
----
R
Q
GID-
L
P
V
T
G
I
A
H
S
P
D
-------
D
T
S
D
L
I
D
M
-
V
-
G
G
A
P
L
V
V
K
L
V
E
G
T
Q
G
I
G
V
V
-
L
A
E
T
R
Q
A
A
E
S
V
I
D
A
F
R
G
----
L
----
N
A
H
-
I
L
V
Q
E
Y
I
K
E
A
Q
G
C
D
I
R
C
L
V
V
-
G
D
E
V
V
A
A
I
E
R
R
A
K
E
G
D
F
R
S
N
L
---
H
R
G
G
--
A
A
S
--
V
----
A
S
I
T
P
Q
E
R
E
I
A
I
K
A
A
---
R
T
M
A
L
D
V
A
G
V
D
I
L
RANR
G
P
-----
L
V
M
E
V
N
A
S
-----------------------------------
40
HHSearch
49.98
18%
-38
- C3 -
-
3VPD
3
LYSX_THET8
B:
[1-280]
---
M
L
A
I
L
Y
D
R
---
I
----
R
P
D
E
R
M
L
F
E
R
A
E
A
L
G
L
P
Y
K
K
V
Y
V
P
A
L
P
M
V
L
G
----------------
E
R
P
E
-------
A
L
E
G
V
T
V
A
L
E
R
C
V
S
Q
S
-----
R
G
L
A
A
A
R
Y
L
T
A
L
G
I
P
V
V
-
N
R
P
E
V
I
E
A
C
G
D
K
W
A
T
S
V
-------
A
L
A
K
A
G
L
P
Q
----
P
K
-
T
A
L
A
T
D
R
E
-------
E
A
L
R
L
M
E
A
-
F
G
Y
P
--
V
V
L
K
P
V
I
G
S
W
G
R
L
L
A
K
V
T
D
R
A
A
-
A
E
A
L
L
E
H
K
E
V
L
GGF
Q
----
H
-
Q
L
F
Y
I
Q
E
Y
V
E
K
P
-
G
R
D
I
R
V
F
V
V
G
E
R
A
I
A
-
A
I
Y
R
--------------------
Q
A
E
--
N
----
C
P
L
T
E
E
I
A
R
L
S
V
G
A
A
E
A
V
---
G
G
G
V
V
A
V
D
L
F
----
E
S
ER
G
L
-
L
V
N
E
V
N
H
T
-
M
E
-
F
K
-----
N
S
V
H
T
T
G
V
D
I
P
G
E
I
L
R
Y
A
W
E
V
A
R
-
43
HHSearch
49.45
18%
-17
* C3 *
-
5K2M
1
?
C:
[1-272]
--
M
R
I
G
I
T
Y
T
V
L
R
-------
R
E
E
M
A
I
K
E
R
A
G
E
F
G
E
-
V
V
M
L
H
E
D
D
L
L
F
P
---------------------------
G
--
N
Y
D
L
D
V
V
I
I
R
N
V
S
H
F
-----
K
A
L
Y
T
A
R
L
F
E
S
E
G
I
P
T
V
-
N
S
S
R
L
I
F
E
A
G
D
K
L
F
A
T
L
-------
R
L
A
GKV-
P
V
----
P
E
-
W
K
A
A
L
S
E
G
-------
G
A
L
R
V
P
D
S
-
L
G
Y
P
--
L
V
S
K
P
V
F
G
S
W
G
R
L
L
A
K
V
N
D
R
D
S
-
L
E
A
V
L
E
H
R
K
W
----
M
KNPL
Y
-
G
I
H
Y
F
Q
E
F
V
E
K
P
-
G
R
D
I
R
S
Y
V
I
G
G
E
F
V
G
-
A
I
Y
R
Y
S
--
N
H
W
I
T
N
T
---
A
R
G
G
--
K
A
E
--
P
----
C
-
S
D
P
E
V
E
E
L
S
V
K
A
W
E
A
F
---
G
E
G
A
L
A
I
D
I
F
----
E
S
EKGL-
L
V
N
E
V
N
P
N
-
M
E
-
F
K
-----
N
A
A
R
V
T
G
A
D
M
A
G
K
L
V
E
Y
A
V
E
V
A
K
-
58
Fugue
47.43
47%
-23
- C3 -
-
1GSA
-
?
?:
[1-122]
-M
I
K
L
G
I
V
M
D
P
I
A
N
I
N
I
K
-
K
D
S
S
F
A
M
L
L
E
A
Q
R
R
G
Y
E
L
H
Y
M
E
M
G
D
L
Y
L
I
N
G
E
A
R
A
H
T
R
T
L
N
V
K
Q
N
Y
E
E
W
F
S
F
V
G
E
Q
D
L
P
L
A
D
L
D
V
I
L
M
R
K
D
P
P
F
D
T
E
F
I
Y
A
T
Y
I
L
E
R
A
E
E
K
G
T
L
I
V
-
N
K
P
Q
S
L
R
D
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
46.34
17%
33
- C3 -
-
5D8D
-
DDL_ACIBC
D:
[8-304]
--
G
K
V
A
V
L
L
G
G
K
S
A
E
R
A
V
S
L
D
S
G
Q
A
V
L
D
A
L
L
R
S
G
V
Q
A
E
A
F
D
P
Q
D
R
S
V
T
---------------------------
E
--
L
V
N
Y
D
R
A
F
I
V
L
H
G
R
G
G
E
----
D
G
Q
I
Q
G
V
L
E
W
L
N
I
P
Y
T
G
T
G
V
Q
G
S
A
I
G
M
D
K
V
K
T
K
Q
-------
I
W
Q
G
S
DL
P
T
----
A
P
-
Y
R
I
I
T
K
E
T
-------
D
L
D
S
V
I
A
E
-
L
G
L
P
--
V
I
I
K
P
V
H
E
G
S
S
V
G
M
S
K
V
E
K
A
E
D
-
F
A
A
A
I
E
K
A
T
Q
----
H
----
D
-
A
V
V
M
A
E
K
W
I
T
G
R
---
E
F
T
I
S
F
L
N
G
Q
P
L
P
-
V
I
R
L
Q
---------------
Y
G
--
I
P
C
G
L
S
----
E
T
E
E
K
K
L
Q
A
L
C
L
R
A
F
Q
A
V
G
--
A
E
G
W
G
R
I
D
A
M
----
Q
D
EQGNF
W
L
L
E
V
N
T
V
-
P
G
M
T
S
H
SLV
P
K
A
A
K
A
V
G
Y
S
F
D
E
L
C
V
A
I
L
E
Q
T
L
--
50
HHSearch
45.47
14%
-48
- C3 -
-
1I7L
1
SYN2_RAT
B:
[4-307]
---
V
L
L
V
V
D
E
P
H
T
----
D
-
W
A
K
C
F
R
G
K
K
I
L
G
D
Y
D
I
K
V
E
Q
A
E
F
S
E
L
N
L
V
A
H
A
D
G
T
Y
A
V
D
M
Q
V
---
L
R
N
G
T
K
-----
V
V
R
S
F
R
P
D
F
V
L
I
R
Q
H
A
F
G
M
A
E
N
E
D
F
R
H
L
V
I
G
M
Q
Y
A
G
L
P
S
I
-
N
S
L
E
S
I
Y
N
F
C
D
K
P
W
V
F
A
QMVAIFK
T
L
G
GEKF
P
L
----
I
E
-
Q
T
Y
Y
P
N
H
R
-------
E
M
---
L
T
L
-
P
T
F
P
--
V
V
V
K
I
G
H
A
H
S
G
M
G
K
V
K
V
E
N
H
Y
D
-
F
Q
D
I
A
S
V
V
A
L
----
T
----
Q
-
T
Y
A
T
A
E
P
F
I
D
A
K
--
Y
D
I
R
V
Q
K
I
G
N
N
Y
K
A
-
Y
M
-
R
T
S
I
S
G
N
W
K
T
N
T
---
G
S
-
A
--
M
L
E
--
Q
----
I
A
M
S
D
R
Y
K
L
W
V
D
A
C
S
E
M
F
G
--
G
L
D
I
C
A
V
K
A
V
----
H
G
KDGKD
Y
I
F
E
V
M
D
C
S
M
P
L
I
G
-----
E
H
Q
V
E
D
R
Q
L
I
T
D
L
V
I
S
K
M
N
Q
L
L
--
56
HHSearch
44.44
14%
13
- C3 -
-
4C5C
5
DDLB_ECOLI
A:
[27-327]
--
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
G
I
D
A
Y
P
V
D
P
K
E
V
D
V
T
Q
------------------
L
K
---------
S
M
G
F
Q
K
V
F
I
A
L
H
G
R
G
G
E
----
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
-------
L
W
Q
G
A
G
L
P
V
----
A
P
-
W
V
A
L
T
R
A
E
F
E
K
GLS
D
K
Q
L
A
E
I
S
A
-
L
G
L
P
--
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
-
L
Q
D
A
L
R
L
A
F
Q
----
H
----
D
-
E
E
V
L
I
E
K
W
L
S
G
P
---
E
F
T
V
A
I
L
G
E
E
I
L
P
-
S
I
R
I
Q
P
S
-
G
T
F
Y
D
Y
E
AKY
L
S
D
E
T
Q
Y
F
C
--
P
AGLE
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
--
C
K
G
W
G
R
I
D
V
M
----
L
D
SDG
Q
F
Y
L
L
E
A
N
T
S
-
P
G
M
T
S
HSL
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
-----