@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VP11: (2017-11-19 )
MGKQVINISGYHMNIPNVLKYYFTETFLKTAIRKPSQLNLPPTALRPMLEQLCRAFPKQKNVTVRPIRLAGIKGEEIKAQDSATQLIFHIHGGAFFLGSLKTHHAFMTDLAARTQMQIIHVDYPLAPEHPYPEATEALYDVYQSLLVQGIQPKDIILSGDSCGANLALALCLRLKEQPELMPSGLILLSPFLDLTLTSESLRFNQKHDALLSLEALQIGIQHYIGNHIAADDPRVSPIFDNLEGLPPTLVQVGSKEILLDDAKRFREKAEEAGVKVHFKLYTGMWHNFQMFNAWFEEAKQAMADIAEFAHELDKT
Atome Classification :
(20 SA)
.........10........20........30...---.....40........50........60........70........80-.-......-.90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MG
K
Q
V
I
N
ISGYHMN
I
P
N
V
L
K
Y
Y
F
T
E
T
F
L
K
T
A
IRK---PSQLNL
P
P
T
A
L
R
P
M
L
E
Q
L
C
R
AFPKQKN
V
T
V
R
P
I
R
L
AGIKGEEIKAQD-S-A
T
Q
L
I
F
-
H
IHG
G
A
F
F
L
GSL
K
T
H
H
A
F
M
T
D
L
AAR
T
Q
M
Q
I
I
H
VDYPLAPEHPY
P
E
A
T
E
A
L
Y
D
V
Y
Q
S
L
L
VQGIQPK
D
I
I
L
SGDSC
G
A
N
L
A
L
A
L
C
L
R
LKEQPELMPS
G
L
I
L
L
SPF
L
D
L
T
L
T
S
E
SLRFNQ
K
H
D
A
L
L
S
L
E
A
L
Q
I
G
I
Q
H
YIGNHIAADDPRV
S
P
I
F
DNLEGL
P
P
T
L
V
QVGS
K
E
I
L
L
D
D
A
K
R
F
R
E
K
A
E
EAG
V
K
V
H
F
K
L
YTGMWH
N
F
Q
M
F
N
A
W
F
E
E
A
K
Q
A
M
A
D
I
A
E
F
A
H
E
LDKT
22
PsiBlast_CBE
92.83
34%
-95
- C1 -
-
3K6K
1
?
D:
[32-303]
--------------------------------------
A
E
K
N
L
P
L
D
Q
K
R
A
G
M
E
A
L
C
E
R
F
P
R
A
E
G
V
E
L
T
L
T
D
L
G
G
V
P
C
I
R
Q
A
T
D
G
-
A
-
G
A
A
H
I
L
-
Y
F
H
G
G
G
Y
I
S
G
S
P
S
T
H
L
V
L
T
T
Q
L
A
K
Q
S
S
A
T
L
W
S
L
D
Y
R
L
A
P
E
N
P
F
P
A
A
V
D
D
C
V
A
A
Y
R
A
L
L
K
T
A
G
S
A
D
R
I
I
I
A
G
D
S
A
G
G
G
L
T
T
A
S
M
L
K
A
K
E
D
G
L
P
M
P
A
G
L
V
M
L
S
P
F
V
D
L
T
L
S
R
W
S
N
S
N
L
A
D
R
D
F
L
A
E
P
D
T
L
G
E
M
S
E
L
Y
V
G
G
E
-
D
R
K
N
P
L
I
S
P
V
Y
A
D
L
S
G
L
P
E
M
L
I
H
V
G
S
E
E
A
L
L
S
D
S
T
T
L
A
E
R
A
G
A
A
G
V
S
V
E
L
K
I
W
P
D
M
P
H
V
F
Q
M
Y
G
K
F
V
N
A
A
D
I
S
I
K
E
I
C
H
W
-------
14
PsiBlast_PDB
92.67
34%
-96
- C1 -
-
3DNM
1
?
A:
[46-317]
--------------------------------------
A
E
K
N
L
P
L
D
Q
K
R
A
G
M
E
A
L
C
E
R
F
P
R
A
E
G
V
E
L
T
L
T
D
L
G
G
V
P
C
I
R
Q
A
T
D
G
-
A
-
G
A
A
H
I
L
-
Y
F
H
G
G
G
Y
I
S
G
S
P
S
T
H
L
V
L
T
T
Q
L
A
K
Q
S
S
A
T
L
W
S
L
D
Y
R
L
A
P
E
N
P
F
P
A
A
V
D
D
C
V
A
A
Y
R
A
L
L
K
T
A
G
S
A
D
R
I
I
I
A
G
D
S
A
G
G
G
L
T
T
A
S
M
L
K
A
K
E
D
G
L
P
M
P
A
G
L
V
M
L
S
P
F
V
D
L
T
L
S
R
W
S
N
S
N
L
A
D
R
D
F
L
A
E
P
D
T
L
G
E
M
S
E
L
Y
V
G
G
E
-
D
R
K
N
P
L
I
S
P
V
Y
A
D
L
S
G
L
P
E
M
L
I
H
V
G
S
E
E
A
L
L
S
D
S
T
T
L
A
E
R
A
G
A
A
G
V
S
V
E
L
K
I
W
P
D
M
P
H
V
F
Q
M
Y
G
K
F
V
N
A
A
D
I
S
I
K
E
I
C
H
W
-------
15
PsiBlast_PDB
92.08
34%
-98
- C1 -
-
3K6K
-
?
A:
[32-303]
--------------------------------------
A
E
K
N
L
P
L
D
Q
K
R
A
G
M
E
A
L
C
E
R
F
P
R
A
E
G
V
E
L
T
L
T
D
L
G
G
V
P
C
I
R
Q
A
T
D
G
-
A
-
G
A
A
H
I
L
-
Y
F
H
G
G
G
Y
I
S
G
S
P
S
T
H
L
V
L
T
T
Q
L
A
K
Q
S
S
A
T
L
W
S
L
D
Y
R
L
A
P
E
N
P
F
P
A
A
V
D
D
C
V
A
A
Y
R
A
L
L
K
T
A
G
S
A
D
R
I
I
I
A
G
D
S
A
G
G
G
L
T
T
A
S
M
L
K
A
K
E
D
G
L
P
M
P
A
G
L
V
M
L
S
P
F
V
D
L
T
L
S
R
W
S
N
S
N
L
A
D
R
D
F
L
A
E
P
D
T
L
G
E
M
S
E
L
Y
V
G
G
E
-
D
R
K
N
P
L
I
S
P
V
Y
A
D
L
S
G
L
P
E
M
L
I
H
V
G
S
E
E
A
L
L
S
D
S
T
T
L
A
E
R
A
G
A
A
G
V
S
V
E
L
K
I
W
P
D
M
P
H
V
F
Q
M
Y
G
K
F
V
N
A
A
D
I
S
I
K
E
I
C
H
W
-------
21
PsiBlast_CBE
90.69
34%
-90
- C1 -
-
3DNM
1
?
B:
[46-317]
--------------------------------------
A
E
K
N
L
P
L
D
Q
K
R
A
G
M
E
A
L
C
E
R
F
P
R
A
E
G
V
E
L
T
L
T
D
L
G
G
V
P
C
I
R
Q
A
T
D
G
-
A
-
G
A
A
H
I
L
-
Y
F
H
G
G
G
Y
I
S
G
S
P
S
T
H
L
V
L
T
T
Q
L
A
K
Q
S
S
A
T
L
W
S
L
D
Y
R
L
A
P
E
N
P
F
P
A
A
V
D
D
C
V
A
A
Y
R
A
L
L
K
T
A
G
S
A
D
R
I
I
I
A
G
D
S
A
G
G
G
L
T
T
A
S
M
L
K
A
K
E
D
G
L
P
M
P
A
G
L
V
M
L
S
P
F
V
D
L
T
L
S
R
W
S
N
S
N
L
A
D
R
D
F
L
A
E
P
D
T
L
G
E
M
S
E
L
Y
V
G
G
E
-
D
R
K
N
P
L
I
S
P
V
Y
A
D
L
S
G
L
P
E
M
L
I
H
V
G
S
E
E
A
L
L
S
D
S
T
T
L
A
E
R
A
G
A
A
G
V
S
V
E
L
K
I
W
P
D
M
P
H
V
F
Q
M
Y
G
K
F
V
N
A
A
D
I
S
I
K
E
I
C
H
W
-------
40
HHSearch
88.75
33%
-94
- C1 -
-
3K6K
-
?
B:
[41-309]
-----------------------------------------------
K
R
A
G
M
E
A
L
C
E
R
F
P
R
A
E
G
V
E
L
T
L
T
D
L
G
G
V
P
C
I
R
Q
A
T
D
G
-
A
-
G
A
A
H
I
L
-
Y
F
H
G
G
G
Y
I
S
G
S
P
S
T
H
L
V
L
T
T
Q
L
A
K
Q
S
S
A
T
L
W
S
L
D
Y
R
L
A
P
E
N
P
F
P
A
A
V
D
D
C
V
A
A
Y
R
A
L
L
K
T
A
G
S
A
D
R
I
I
I
A
G
D
S
A
G
G
G
L
T
T
A
S
M
L
K
A
K
E
D
G
L
P
M
P
A
G
L
V
M
L
S
P
F
V
D
L
T
L
S
R
W
S
N
S
N
L
A
D
R
D
F
L
A
E
P
D
T
L
G
E
M
S
E
L
Y
V
G
G
E
-
D
R
K
N
P
L
I
S
P
V
Y
A
D
L
S
G
L
P
E
M
L
I
H
V
G
S
E
E
A
L
L
S
D
S
T
T
L
A
E
R
A
G
A
A
G
V
S
V
E
L
K
I
W
P
D
M
P
H
V
F
Q
M
Y
G
K
F
V
N
A
A
D
I
S
I
K
E
I
C
H
W
I
S
A
R
I
S
-
9
PsiBlast_PDB
82.77
32%
-27
- C1 -
-
3H1B
-
?
A:
[1-293]
------------
M
A
G
P
E
I
V
K
-------
L
K
K
I
L
R
E
K
AV
P
P
G
T
E
V
P
L
D
V
M
R
K
G
M
E
K
V
--
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
-
C
Q
A
G
K
A
I
L
-
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
K
T
R
A
E
A
D
P
M
V
A
P
G
G
I
N
K
M
A
A
R
Y
L
-
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
----
1
PsiBlast_PDB
82.42
32%
-28
- C1 -
-
3FAK
-
?
A:
[14-306]
------------
M
A
G
P
E
I
V
K
-------
L
K
K
I
L
R
E
K
AV
P
P
G
T
E
V
P
L
D
V
M
R
K
G
M
E
K
V
--
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
-
C
Q
A
G
K
A
I
L
-
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
K
T
R
A
E
A
D
P
M
V
A
P
G
G
I
N
K
M
A
A
R
Y
L
-
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
----
4
PsiBlast_PDB
81.54
32%
-28
- C1 -
-
3G9Z
-
?
A:
[1-293]
------------
M
A
G
P
E
I
V
K
-------
L
K
K
I
L
R
E
K
AV
P
P
G
T
E
V
P
L
D
V
M
R
K
G
M
E
K
V
--
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
-
C
Q
A
G
K
A
I
L
-
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
K
T
R
A
E
A
D
P
M
V
A
P
G
G
I
N
K
M
A
A
R
Y
L
-
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
----
8
PsiBlast_PDB
81.41
32%
-27
- C1 -
-
3H1A
-
?
A:
[2-293]
-------------
A
G
P
E
I
V
K
-------
L
K
K
I
L
R
E
K
AV
P
P
G
T
E
V
P
L
D
V
M
R
K
G
M
E
K
V
--
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
-
C
Q
A
G
K
A
I
L
-
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
K
T
R
A
E
A
D
P
M
V
A
P
G
G
I
N
K
M
A
A
R
Y
L
-
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
----
11
PsiBlast_PDB
80.44
32%
-28
- C1 -
-
3L1I
-
?
A:
[1-293]
------------
M
A
G
P
E
I
V
K
-------
L
K
K
I
L
R
E
K
AV
P
P
G
T
E
V
P
L
D
V
M
R
K
G
M
E
K
V
--
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
-
C
Q
A
G
K
A
I
L
-
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
K
T
R
A
E
A
D
P
M
---
G
G
I
N
K
M
A
A
R
Y
L
-
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
----
5
PsiBlast_PDB
79.94
32%
-30
- C1 -
-
3H17
1
?
A:
[15-306]
-------------
A
G
P
E
I
V
K
-------
L
K
K
I
L
R
E
K
AV
P
P
G
T
E
V
P
L
D
V
M
R
K
G
M
E
K
V
--
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
-
C
Q
A
G
K
A
I
L
-
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
K
T
R
A
E
A
D
----
P
G
G
I
N
K
M
A
A
R
Y
L
-
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
----
12
PsiBlast_PDB
79.89
32%
-29
- C1 -
-
3L1J
-
?
A:
[1-293]
------------
M
A
G
P
E
I
V
K
-------
L
K
K
I
L
R
E
K
AV
P
P
G
T
E
V
P
L
D
V
M
R
K
G
M
E
K
V
--
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
-
C
Q
A
G
K
A
I
L
-
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
K
T
R
A
E
A
D
P
M
---
G
G
I
N
K
M
A
A
R
Y
L
-
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
----
10
PsiBlast_PDB
79.21
32%
-29
- C1 -
-
3L1H
-
?
A:
[1-293]
------------
M
A
G
P
E
I
V
K
-------
L
K
K
I
L
R
E
K
AV
P
P
G
T
E
V
P
L
D
V
M
R
K
G
M
E
K
V
--
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
-
C
Q
A
G
K
A
I
L
-
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
K
T
R
A
E
A
D
P
M
---
G
G
I
N
K
M
A
A
R
Y
L
-
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
----
6
PsiBlast_PDB
78.61
32%
-29
- C1 -
-
3H18
2
?
A:
[15-306]
-------------
A
G
P
E
I
V
K
-------
L
K
K
I
L
R
E
K
AV
P
P
G
T
E
V
P
L
D
V
M
R
K
G
M
E
K
V
--
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
-
C
Q
A
G
K
A
I
L
-
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
K
T
R
A
E
A
D
P
M
---
G
G
I
N
K
M
A
A
R
Y
L
-
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
----
7
PsiBlast_PDB
78.45
32%
-29
- C1 -
-
3H19
-
?
A:
[2-293]
-------------
A
G
P
E
I
V
K
-------
L
K
K
I
L
R
E
K
AV
P
P
G
T
E
V
P
L
D
V
M
R
K
G
M
E
K
V
--
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
-
C
Q
A
G
K
A
I
L
-
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
K
T
R
A
E
A
D
P
M
---
G
G
I
N
K
M
A
A
R
Y
L
-
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
----
2
PsiBlast_PDB
77.95
32%
-28
- C1 -
-
3G9T
-
?
A:
[2-293]
-------------
A
G
P
E
I
V
K
-------
L
K
K
I
L
R
E
K
AV
P
P
G
T
E
V
P
L
D
V
M
R
K
G
M
E
K
V
--
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
-
C
Q
A
G
K
A
I
L
-
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
K
T
R
A
E
A
D
P
M
--
P
G
G
I
N
K
M
A
A
R
Y
L
-
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
----
3
PsiBlast_PDB
77.44
32%
-27
- C1 -
-
3G9U
-
?
A:
[2-293]
-------------
A
G
P
E
I
V
K
-------
L
K
K
I
L
R
E
K
AV
P
P
G
T
E
V
P
L
D
V
M
R
K
G
M
E
K
V
--
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
-
C
Q
A
G
K
A
I
L
-
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
K
T
R
A
E
A
D
P
M
--
P
G
G
I
N
K
M
A
A
R
Y
L
-
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
----
13
PsiBlast_PDB
76.63
33%
-25
- C1 -
-
3V9A
-
?
A:
[9-293]
---------------------------
L
K
K
I
L
R
E
K
AV
P
P
G
T
E
V
P
L
D
V
M
R
K
G
M
E
K
V
--
A
F
K
A
A
D
D
I
Q
V
E
Q
V
T
V
A
G
C
A
A
E
W
V
R
A
P
G
-
C
Q
A
G
K
A
I
L
-
Y
L
H
G
G
G
Y
V
M
G
S
I
N
T
H
R
S
M
V
G
E
I
S
R
A
S
Q
A
A
A
L
L
L
D
Y
R
L
A
P
E
H
P
F
P
A
A
V
E
D
G
V
A
A
Y
R
W
L
L
D
Q
G
F
K
P
Q
H
L
S
I
S
G
D
S
A
G
G
G
L
V
L
A
V
L
V
S
A
R
D
Q
G
L
P
M
P
A
S
A
I
P
I
S
P
W
A
D
M
T
C
T
N
D
S
F
K
T
R
A
E
A
D
P
M
---
G
G
I
N
K
M
A
A
R
Y
L
-
N
G
A
D
A
K
H
P
Y
A
S
P
N
F
A
N
L
K
G
L
P
P
L
L
I
H
V
G
R
D
E
V
L
L
D
D
S
I
K
L
D
A
K
A
K
A
D
G
V
K
S
T
L
E
I
W
D
D
M
I
H
V
W
H
A
F
H
P
M
L
P
E
G
K
Q
A
I
V
R
V
G
E
F
M
R
E
----
31
HHSearch
76.46
33%
-44
* C1 *
-
5GMS
-
?
A:
[42-312]
---------------------------------------------
D
D
D
R
R
L
Y
E
T
M
L
G
S
M
P
L
D
D
D
I
Q
T
E
R
L
G
V
N
G
V
P
A
E
W
I
Y
A
P
G
A
R
-
D
D
Q
V
F
L
-
Y
L
H
G
G
G
Y
V
I
G
S
M
R
T
H
R
V
M
L
S
H
I
A
R
A
A
G
C
R
V
L
G
L
D
Y
R
L
A
P
E
T
P
F
P
A
P
V
E
D
T
V
A
A
Y
R
W
L
L
A
H
G
Y
D
P
S
R
I
A
L
G
G
D
S
A
G
G
G
L
V
V
A
A
L
V
A
L
R
Y
I
G
E
P
L
P
A
A
G
V
C
L
S
P
W
I
D
M
E
A
T
G
E
S
F
T
T
N
A
T
M
D
P
S
V
N
K
E
R
V
M
W
F
A
A
L
Y
L
G
G
K
-
N
P
Q
A
P
L
A
S
P
L
Y
A
D
L
Q
G
L
P
P
L
L
V
Q
V
G
G
I
E
T
L
L
D
D
A
R
A
L
T
T
R
A
K
A
A
G
V
D
A
D
L
E
V
W
D
D
M
P
H
V
W
Q
H
F
A
P
I
L
P
E
G
K
Q
A
I
A
R
I
G
E
F
L
R
K
Q
I
--
27
PsiBlast_CBE
74.08
33%
-41
- C1 -
-
4XVC
1
?
E:
[49-311]
------------------------------------------------
R
R
L
Y
E
T
M
L
G
S
M
P
L
D
D
D
I
Q
T
E
R
L
G
V
N
G
V
P
A
E
W
I
Y
A
P
G
-
A
-
R
D
D
Q
V
F
L
Y
L
H
G
G
G
Y
V
I
G
S
M
R
T
H
R
V
M
L
S
H
I
A
R
A
A
G
C
R
V
L
G
L
D
Y
R
L
A
P
E
T
P
F
P
A
P
V
E
D
T
V
A
A
Y
R
W
L
L
A
H
G
Y
D
P
S
R
I
A
L
G
G
D
S
A
G
G
G
L
V
V
A
A
L
V
A
L
R
Y
I
G
E
P
L
P
A
A
G
V
C
L
S
P
W
I
D
M
E
A
T
G
E
S
F
T
T
N
A
T
M
D
P
S
V
N
K
E
R
V
M
S
I
A
A
L
Y
L
G
G
K
-
N
P
Q
A
P
L
A
S
P
L
Y
A
D
L
Q
G
L
P
P
L
L
V
Q
V
G
G
I
E
T
L
L
D
D
A
R
A
L
T
T
R
A
K
A
A
G
V
D
A
D
L
E
V
W
D
D
M
P
H
V
W
Q
H
F
A
P
I
L
P
E
G
K
Q
A
I
A
R
I
G
E
F
-------