@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VP17: (2017-11-19 )
MQADFLNFYEKLNKRRAIVSESYLSGAELIKQIQKSPYSRDLIGYHGQPPEVKWPNNAKVAVQFVLNYEEGGEKHIEHGDEGSEQFLSEIIGAASYPAKHMSMDSMYEYGSRAGFWRIHSEFQRRKLPMTIFGVAMALVRNPYIVEAIKQADYDVVSHGCRWLHYQETDLEVEEQHMEQALSVLENLFGNKTIGWYTGRDSPNTRQLLAEFPQIQYDSDYYGDDLPFWTTLTDTAGASRPHLIIPYTLECNDMKFCSPGGFNSSEQFFQYLKDSFDVLYAEGETAPKMMSIGMHCRILGRPGRFKALQRFLDYIEMHDRVWVCRRQDIAEYWYKNHINQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70-........80........90.....-..-.100.......110-.-......120......-.130.......140.......150.......160.......170.......180.......190..----....--.200.--.-.....210.....-..220..-.....230.-----------------.-.....240.......-----250---------------------------....--...------260-----.........270.......280.......290.......300.-......310.......320........330.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQ
A
D
F
L
N
F
Y
E
K
L
N
K
R
R
A
I
V
S
E
SYL
S
G
A
E
L
I
K
Q
I
Q
KSPYSRDLIGYHGQPPEVKWPNN
A
K
V
A
V
Q
F
V
L
NYEEG-
G
E
K
HIEHGDE
G
S
E
Q
F
L
S
E
I
IGAASY-
P
A
-
K
HM
S
M
D
S
M
Y
E
YGSR-A-G
F
W
R
I
H
S
E
F
Q
RRKL
P
-
M
T
I
F
G
V
A
M
A
L
VRN
P
Y
I
V
E
A
I
K
QA
D
Y
D
V
V
SHG
C
R
W
L
H
YQETDL
E
V
E
E
Q
H
M
E
Q
A
L
S
V
L
E
N
L
FGNK
T
I
G
----
W
YTG--RDSP
N
--
T
-
R
Q
L
L
A
EFPQIQYD-SDYYGDD-LP
F
W
T
T
LTD-----------------T-AGASR
P
H
L
I
I
P
Y
T
LE-----CND---------------------------
M
K
FC--SPG------G-------FN
S
S
E
Q
F
F
Q
Y
L
K
DSF
D
V
L
Y
AEGETAP
K
M
M
S
IG
M
H
C
R
I
LGRP
G
R
-
F
K
A
L
Q
R
F
L
D
Y
I
E
MHD
R
V
-
W
V
C
R
R
Q
D
I
A
E
Y
W
Y
K
NHINQ
1
PsiBlast_PDB
99.10
60%
-99
- C3 -
-
3S6O
-
?
A:
[11-309]
-------------------------------------
Y
P
R
D
L
I
G
Y
G
R
H
P
V
Q
A
N
W
P
G
R
A
R
V
A
V
Q
F
V
L
N
Y
E
E
G
-
G
E
N
C
V
L
H
G
D
P
A
S
E
Q
F
L
S
E
I
V
G
A
A
A
Y
-
P
A
-
R
H
M
S
M
E
S
I
Y
E
Y
G
S
R
-
A
-
G
V
W
R
I
L
R
E
F
D
K
R
G
L
P
-
L
T
V
F
G
V
G
M
A
I
E
R
H
P
E
L
A
R
A
F
V
E
L
G
H
E
I
A
C
H
G
W
R
W
I
H
Y
Q
D
M
T
P
E
R
E
A
E
H
M
R
L
G
M
E
A
I
E
R
V
T
G
V
R
P
L
G
----
W
Y
T
G
--
R
D
S
P
N
--
T
-
H
R
L
V
A
E
Y
G
G
F
L
Y
D
-
S
D
H
Y
G
D
D
-
L
P
F
W
M
D
V
E
V
-----------------
S
-
G
G
A
S
V
P
Q
L
I
V
P
Y
T
L
D
-----
A
N
D
---------------------------
M
R
F
A
--
T
P
Q
------
G
-------
F
N
T
A
D
H
F
F
H
Y
L
R
D
A
F
D
V
L
Y
E
E
G
D
E
A
P
K
M
M
S
I
G
M
H
C
R
L
L
G
R
P
G
R
-
F
R
A
L
Q
R
F
L
D
H
I
E
R
H
D
R
V
-
W
V
A
R
R
V
E
I
A
R
H
W
R
E
H
H
---
13
HHSearch
98.92
59%
-98
- C3 -
-
3S6O
-
?
A:
[7-311]
---------------------------------
F
D
P
N
Y
P
R
D
L
I
G
Y
G
R
H
P
V
Q
A
N
W
P
G
R
A
R
V
A
V
Q
F
V
L
N
Y
E
E
G
-
G
E
N
C
V
L
H
G
D
P
A
S
E
Q
F
L
S
E
I
V
G
A
A
A
Y
-
P
A
-
R
H
M
S
M
E
S
I
Y
E
Y
G
S
R
-
A
-
G
V
W
R
I
L
R
E
F
D
K
R
G
L
P
-
L
T
V
F
G
V
G
M
A
I
E
R
H
P
E
L
A
R
A
F
V
E
L
G
H
E
I
A
C
H
G
W
R
W
I
H
Y
Q
D
M
T
P
E
R
E
A
E
H
M
R
L
G
M
E
A
I
E
R
V
T
G
V
R
P
L
G
----
W
Y
T
G
--
R
D
S
P
N
--
T
-
H
R
L
V
A
E
Y
G
G
F
L
Y
D
-
S
D
H
Y
G
D
D
-
L
P
F
W
M
D
V
E
V
-----------------
S
-
G
G
A
S
V
P
Q
L
I
V
P
Y
T
L
D
-----
A
N
D
---------------------------
M
R
F
A
--
T
P
Q
------
G
-------
F
N
T
A
D
H
F
F
H
Y
L
R
D
A
F
D
V
L
Y
E
E
G
D
E
A
P
K
M
M
S
I
G
M
H
C
R
L
L
G
R
P
G
R
-
F
R
A
L
Q
R
F
L
D
H
I
E
R
H
D
R
V
-
W
V
A
R
R
V
E
I
A
R
H
W
R
E
H
H
P
Y
-
10
PsiBlast_CBE
98.90
60%
-98
- C3 -
-
3S6O
2
?
B:
[11-309]
-------------------------------------
Y
P
R
D
L
I
G
Y
G
R
H
P
V
Q
A
N
W
P
G
R
A
R
V
A
V
Q
F
V
L
N
Y
E
E
G
-
G
E
N
C
V
L
H
G
D
P
A
S
E
Q
F
L
S
E
I
V
G
A
A
A
Y
-
P
A
-
R
H
M
S
M
E
S
I
Y
E
Y
G
S
R
-
A
-
G
V
W
R
I
L
R
E
F
D
K
R
G
L
P
-
L
T
V
F
G
V
G
M
A
I
E
R
H
P
E
L
A
R
A
F
V
E
L
G
H
E
I
A
C
H
G
W
R
W
I
H
Y
Q
D
M
T
P
E
R
E
A
E
H
M
R
L
G
M
E
A
I
E
R
V
T
G
V
R
P
L
G
----
W
Y
T
G
--
R
D
S
P
N
--
T
-
H
R
L
V
A
E
Y
G
G
F
L
Y
D
-
S
D
H
Y
G
D
D
-
L
P
F
W
M
D
V
E
V
-----------------
S
-
G
G
A
S
V
P
Q
L
I
V
P
Y
T
L
D
-----
A
N
D
---------------------------
M
R
F
A
--
T
P
Q
------
G
-------
F
N
T
A
D
H
F
F
H
Y
L
R
D
A
F
D
V
L
Y
E
E
G
D
E
A
P
K
M
M
S
I
G
M
H
C
R
L
L
G
R
P
G
R
-
F
R
A
L
Q
R
F
L
D
H
I
E
R
H
D
R
V
-
W
V
A
R
R
V
E
I
A
R
H
W
R
E
H
H
---
9
PsiBlast_CBE
98.04
60%
-100
- C3 -
-
3S6O
2
?
C:
[11-309]
-------------------------------------
Y
P
R
D
L
I
G
Y
G
R
H
P
V
Q
A
N
W
P
G
R
A
R
V
A
V
Q
F
V
L
N
Y
E
E
G
-
G
E
N
C
V
L
H
G
D
P
A
S
E
Q
F
L
S
E
I
V
G
A
A
A
Y
-
P
A
-
R
H
M
S
M
E
S
I
Y
E
Y
G
S
R
-
A
-
G
V
W
R
I
L
R
E
F
D
K
R
G
L
P
-
L
T
V
F
G
V
G
M
A
I
E
R
H
P
E
L
A
R
A
F
V
E
L
G
H
E
I
A
C
H
G
W
R
W
I
H
Y
Q
D
M
T
P
E
R
E
A
E
H
M
R
L
G
M
E
A
I
E
R
V
T
G
V
R
P
L
G
----
W
Y
T
G
--
R
D
S
P
N
--
T
-
H
R
L
V
A
E
Y
G
G
F
L
Y
D
-
S
D
H
Y
G
D
D
-
L
P
F
W
M
D
V
E
V
-----------------
S
-
G
G
A
S
V
P
Q
L
I
V
P
Y
T
L
D
-----
A
N
D
---------------------------
M
R
F
A
--
T
P
Q
------
G
-------
F
N
T
A
D
H
F
F
H
Y
L
R
D
A
F
D
V
L
Y
E
E
G
D
E
A
P
K
M
M
S
I
G
M
H
C
R
L
L
G
R
P
G
R
-
F
R
A
L
Q
R
F
L
D
H
I
E
R
H
D
R
V
-
W
V
A
R
R
V
E
I
A
R
H
W
R
E
H
H
---
12
HHSearch
97.83
59%
-99
- C3 -
-
3S6O
2
?
C:
[7-311]
---------------------------------
F
D
P
N
Y
P
R
D
L
I
G
Y
G
R
H
P
V
Q
A
N
W
P
G
R
A
R
V
A
V
Q
F
V
L
N
Y
E
E
G
-
G
E
N
C
V
L
H
G
D
P
A
S
E
Q
F
L
S
E
I
V
G
A
A
A
Y
-
P
A
-
R
H
M
S
M
E
S
I
Y
E
Y
G
S
R
-
A
-
G
V
W
R
I
L
R
E
F
D
K
R
G
L
P
-
L
T
V
F
G
V
G
M
A
I
E
R
H
P
E
L
A
R
A
F
V
E
L
G
H
E
I
A
C
H
G
W
R
W
I
H
Y
Q
D
M
T
P
E
R
E
A
E
H
M
R
L
G
M
E
A
I
E
R
V
T
G
V
R
P
L
G
----
W
Y
T
G
--
R
D
S
P
N
--
T
-
H
R
L
V
A
E
Y
G
G
F
L
Y
D
-
S
D
H
Y
G
D
D
-
L
P
F
W
M
D
V
E
V
-----------------
S
-
G
G
A
S
V
P
Q
L
I
V
P
Y
T
L
D
-----
A
N
D
---------------------------
M
R
F
A
--
T
P
Q
------
G
-------
F
N
T
A
D
H
F
F
H
Y
L
R
D
A
F
D
V
L
Y
E
E
G
D
E
A
P
K
M
M
S
I
G
M
H
C
R
L
L
G
R
P
G
R
-
F
R
A
L
Q
R
F
L
D
H
I
E
R
H
D
R
V
-
W
V
A
R
R
V
E
I
A
R
H
W
R
E
H
H
P
Y
-
11
PsiBlast_CBE
81.47
52%
-11
- C3 -
-
3CL8
1
?
B:
[5-301]
-------------------------------------
Y
P
R
D
L
I
G
Y
G
S
N
P
P
H
P
H
W
P
G
K
A
R
I
A
L
S
F
V
L
N
Y
E
E
G
-
G
E
R
N
I
L
H
G
D
K
E
S
E
A
F
L
S
E
M
V
S
A
Q
P
L
-
Q
G
E
R
N
M
S
M
E
S
L
Y
E
Y
G
S
R
-
A
-
G
V
W
R
I
L
K
L
F
K
A
F
D
I
P
-
L
T
I
F
A
V
A
M
A
A
Q
R
H
P
D
V
I
R
A
M
V
A
A
G
H
E
I
C
S
H
G
Y
R
W
I
D
Y
Q
Y
M
D
E
A
Q
E
R
E
H
M
L
E
A
I
R
I
L
T
E
L
T
G
E
R
P
L
G
----
W
Y
T
G
--
R
T
G
P
N
--
T
-
R
R
L
V
M
E
E
G
G
F
L
Y
D
-
C
D
T
Y
D
D
D
-
L
P
Y
W
E
P
N
N
P
-----------------
T
-
G
---
K
P
H
L
V
I
P
Y
T
L
D
-----
T
N
D
---------------------------
M
R
F
T
--
Q
V
Q
------
G
-------
F
N
K
G
D
D
F
F
E
Y
L
K
D
A
F
D
V
L
Y
A
E
G
A
E
A
P
K
M
L
S
I
G
L
H
C
R
L
I
G
R
P
A
R
-
L
A
A
L
Q
R
F
I
E
Y
A
K
S
H
E
Q
V
-
W
F
T
R
R
V
D
I
A
R
H
W
H
A
T
H
---
5
PsiBlast_PDB
80.66
52%
-10
- C3 -
-
1Z7A
3
?
A:
[5-301]
-------------------------------------
Y
P
R
D
L
I
G
Y
G
N
N
P
P
H
P
H
W
P
G
D
A
R
I
A
L
S
F
V
L
N
Y
E
E
G
-
G
E
R
C
V
L
H
G
D
K
E
S
E
A
F
L
S
E
M
V
A
A
Q
P
L
-
Q
G
V
R
H
M
S
M
E
S
L
Y
E
Y
G
S
R
-
A
-
G
V
W
R
L
L
K
L
F
K
R
R
N
V
P
-
L
T
V
F
A
V
A
M
A
A
Q
R
N
P
E
V
I
R
A
M
V
A
D
G
H
E
I
C
S
H
G
Y
R
W
I
D
Y
Q
Y
M
D
E
A
Q
E
R
E
H
M
L
E
A
I
R
I
L
T
E
L
T
G
Q
R
P
V
G
----
W
Y
T
G
--
R
T
G
P
N
--
T
-
R
R
L
V
M
E
E
G
G
F
L
Y
D
-
S
D
T
Y
D
D
D
-
L
P
Y
W
D
P
--------------------
A
-
S
T
A
E
K
P
H
L
V
I
P
Y
T
L
D
-----
T
N
D
---------------------------
M
R
F
T
--
Q
V
Q
------
G
-------
F
N
N
G
E
Q
F
F
Q
Y
L
K
D
A
F
D
V
L
Y
E
E
G
A
T
A
P
K
M
L
S
I
G
L
H
C
R
L
I
G
R
P
A
R
-
M
A
A
L
E
R
F
I
Q
Y
A
Q
S
H
D
K
V
-
W
F
A
R
R
E
D
I
A
R
H
W
H
R
E
H
---
14
HHSearch
79.64
52%
-2
- C3 -
-
3CL8
1
?
B:
[3-303]
-----------------------------------
V
D
Y
P
R
D
L
I
G
Y
G
S
N
P
P
H
P
H
W
P
G
K
A
R
I
A
L
S
F
V
L
N
Y
E
E
G
-
G
E
R
N
I
L
H
G
D
K
E
S
E
A
F
L
S
E
M
V
S
A
Q
P
L
Q
G
E
-
R
N
M
S
M
E
S
L
Y
E
Y
G
S
R
-
A
-
G
V
W
R
I
L
K
L
F
K
A
F
D
I
P
-
L
T
I
F
A
V
A
M
A
A
Q
R
H
P
D
V
I
R
A
M
V
A
A
G
H
E
I
C
S
H
G
Y
R
W
I
D
Y
Q
Y
M
D
E
A
Q
E
R
E
H
M
L
E
A
I
R
I
L
T
E
L
T
G
E
R
P
L
G
----
W
Y
T
G
--
R
T
G
P
N
--
T
R
R
L
V
M
E
E
G
-
G
F
L
Y
D
-
C
D
T
Y
D
D
D
-
L
P
Y
W
E
P
N
N
---------------------
P
T
G
K
P
H
L
V
I
P
Y
T
L
D
-----
T
N
D
---------------------------
M
R
F
T
--
Q
V
Q
------
G
-------
F
N
K
G
D
D
F
F
E
Y
L
K
D
A
F
D
V
L
Y
A
E
G
A
E
A
P
K
M
L
S
I
G
L
H
C
R
L
I
G
R
P
A
R
-
L
A
A
L
Q
R
F
I
E
Y
A
K
S
H
E
Q
V
-
W
F
T
R
R
V
D
I
A
R
H
W
H
A
T
H
P
Y
-
3
PsiBlast_PDB
79.27
52%
-10
- C3 -
-
3CL7
-
?
A:
[5-301]
-------------------------------------
Y
P
R
D
L
I
G
Y
G
S
N
P
P
H
P
H
W
P
G
K
A
R
I
A
L
S
F
V
L
N
Y
E
E
G
-
G
E
R
N
I
L
H
G
D
K
E
S
E
A
F
L
S
E
M
V
S
A
Q
P
L
-
Q
G
E
R
N
M
S
M
E
S
L
Y
E
Y
G
S
R
-
A
-
G
V
W
R
I
L
K
L
F
K
A
F
D
I
P
-
L
T
I
F
A
V
A
M
A
A
Q
R
H
P
D
V
I
R
A
M
V
A
A
G
H
E
I
C
S
H
G
Y
R
W
I
D
Y
Q
Y
M
D
E
A
Q
E
R
E
H
M
L
E
A
I
R
I
L
T
E
L
T
G
E
R
P
L
G
----
W
Y
T
G
--
R
T
G
P
N
--
T
-
R
R
L
V
M
E
E
G
G
F
L
Y
D
-
C
D
T
Y
D
D
D
-
L
P
Y
W
E
P
N
N
P
-----------------
T
-
G
---
K
P
H
L
V
I
P
Y
T
L
D
-----
T
N
D
---------------------------
M
R
F
T
--
Q
V
Q
------
G
-------
F
N
K
G
D
D
F
F
E
Y
L
K
D
A
F
D
V
L
Y
A
E
G
A
E
A
P
K
M
L
S
I
G
L
H
C
R
L
I
G
R
P
A
R
-
L
A
A
L
Q
R
F
I
E
Y
A
K
S
H
E
Q
V
-
W
F
T
R
R
V
D
I
A
R
H
W
H
A
T
H
---
4
PsiBlast_PDB
78.59
52%
-11
- C3 -
-
3CL8
1
?
A:
[5-301]
-------------------------------------
Y
P
R
D
L
I
G
Y
G
S
N
P
P
H
P
H
W
P
G
K
A
R
I
A
L
S
F
V
L
N
Y
E
E
G
-
G
E
R
N
I
L
H
G
D
K
E
S
E
A
F
L
S
E
M
V
S
A
Q
P
L
-
Q
G
E
R
N
M
S
M
E
S
L
Y
E
Y
G
S
R
-
A
-
G
V
W
R
I
L
K
L
F
K
A
F
D
I
P
-
L
T
I
F
A
V
A
M
A
A
Q
R
H
P
D
V
I
R
A
M
V
A
A
G
H
E
I
C
S
H
G
Y
R
W
I
D
Y
Q
Y
M
D
E
A
Q
E
R
E
H
M
L
E
A
I
R
I
L
T
E
L
T
G
E
R
P
L
G
----
W
Y
T
G
--
R
T
G
P
N
--
T
-
R
R
L
V
M
E
E
G
G
F
L
Y
D
-
C
D
T
Y
D
D
D
-
L
P
Y
W
E
P
N
N
P
-----------------
T
-
G
---
K
P
H
L
V
I
P
Y
T
L
D
-----
T
N
D
---------------------------
M
R
F
T
--
Q
V
Q
------
G
-------
F
N
K
G
D
D
F
F
E
Y
L
K
D
A
F
D
V
L
Y
A
E
G
A
E
A
P
K
M
L
S
I
G
L
H
C
R
L
I
G
R
P
A
R
-
L
A
A
L
Q
R
F
I
E
Y
A
K
S
H
E
Q
V
-
W
F
T
R
R
V
D
I
A
R
H
W
H
A
T
H
---
2
PsiBlast_PDB
78.34
52%
-13
- C- -
-
3CL6
-
?
A:
[5-301]
-------------------------------------
Y
P
R
D
L
I
G
Y
G
S
N
P
P
H
P
H
W
P
G
K
A
R
I
A
L
S
F
V
L
N
Y
E
E
G
-
G
E
R
N
I
L
H
G
D
K
E
S
E
A
F
L
S
E
M
V
S
A
Q
P
L
-
Q
G
E
R
N
M
S
M
E
S
L
Y
E
Y
G
S
R
-
A
-
G
V
W
R
I
L
K
L
F
K
A
F
D
I
P
-
L
T
I
F
A
V
A
M
A
A
Q
R
H
P
D
V
I
R
A
M
V
A
A
G
H
E
I
C
S
H
G
Y
R
W
I
D
Y
Q
Y
M
D
E
A
Q
E
R
E
H
M
L
E
A
I
R
I
L
T
E
L
T
G
E
R
P
L
G
----
W
Y
T
G
--
R
T
G
P
N
--
T
-
R
R
L
V
M
E
E
G
G
F
L
Y
D
-
C
D
T
Y
D
D
D
-
L
P
Y
W
E
P
N
N
P
-----------------
T
-
G
---
K
P
H
L
V
I
P
Y
T
L
D
-----
T
N
D
---------------------------
M
R
F
T
--
Q
V
Q
------
G
-------
F
N
K
G
D
D
F
F
E
Y
L
K
D
A
F
D
V
L
Y
A
E
G
A
E
A
P
K
M
L
S
I
G
L
H
C
R
L
I
G
R
P
A
R
-
L
A
A
L
Q
R
F
I
E
Y
A
K
S
H
E
Q
V
-
W
F
T
R
R
V
D
I
A
R
H
W
H
A
T
H
---
15
HHSearch
76.97
52%
-3
- C- -
-
3CL6
-
?
A:
[3-303]
-----------------------------------
V
D
Y
P
R
D
L
I
G
Y
G
S
N
P
P
H
P
H
W
P
G
K
A
R
I
A
L
S
F
V
L
N
Y
E
E
G
-
G
E
R
N
I
L
H
G
D
K
E
S
E
A
F
L
S
E
M
V
S
A
Q
P
L
Q
G
E
-
R
N
M
S
M
E
S
L
Y
E
Y
G
S
R
-
A
-
G
V
W
R
I
L
K
L
F
K
A
F
D
I
P
-
L
T
I
F
A
V
A
M
A
A
Q
R
H
P
D
V
I
R
A
M
V
A
A
G
H
E
I
C
S
H
G
Y
R
W
I
D
Y
Q
Y
M
D
E
A
Q
E
R
E
H
M
L
E
A
I
R
I
L
T
E
L
T
G
E
R
P
L
G
----
W
Y
T
G
--
R
T
G
P
N
--
T
R
R
L
V
M
E
E
G
-
G
F
L
Y
D
-
C
D
T
Y
D
D
D
-
L
P
Y
W
E
P
N
N
---------------------
P
T
G
K
P
H
L
V
I
P
Y
T
L
D
-----
T
N
D
---------------------------
M
R
F
T
--
Q
V
Q
------
G
-------
F
N
K
G
D
D
F
F
E
Y
L
K
D
A
F
D
V
L
Y
A
E
G
A
E
A
P
K
M
L
S
I
G
L
H
C
R
L
I
G
R
P
A
R
-
L
A
A
L
Q
R
F
I
E
Y
A
K
S
H
E
Q
V
-
W
F
T
R
R
V
D
I
A
R
H
W
H
A
T
H
P
Y
-
6
PsiBlast_PDB
67.92
22%
-73
- C3 -
-
3RXZ
-
?
A:
[17-279]
---------------------------------------------------
V
S
W
P
D
G
K
T
C
A
V
A
F
T
F
D
V
D
A
E
-----------------
S
P
L
L
T
T
D
P
A
-
F
A
-
D
R
M
G
T
M
S
H
Q
A
Y
G
P
L
-
V
-
G
V
P
R
L
L
G
I
L
D
E
F
N
V
P
-
G
T
F
F
V
P
G
Y
T
A
H
R
H
P
E
P
I
R
S
I
A
R
A
G
H
E
I
A
H
H
G
Y
L
H
E
S
L
V
G
A
D
E
D
T
E
R
K
I
L
T
R
G
I
E
A
L
E
E
V
A
G
V
H
P
V
G
----
Y
R
A
P
--
M
W
E
M
N
WH
T
-
P
K
L
L
A
E
F
-
G
F
L
Y
D
-
S
T
L
M
D
S
D
-
H
P
Y
E
L
A
V
G
D
---------------------
G
S
L
V
E
L
P
V
S
W
A
L
D
DWQQ
Y
C
F
V
---------------------------
P
D
F
S
--
G
T
G
------
L
-------
I
E
T
P
A
K
A
I
E
L
W
R
A
E
L
N
A
M
R
D
I
G
----
G
A
W
V
L
T
N
H
P
F
L
S
G
R
P
G
R
-
A
A
A
L
R
E
F
I
A
E
V
C
A
M
D
D
V
-
W
V
A
G
M
S
Q
I
A
E
H
--------
17
HHSearch
62.85
22%
-19
- C3 -
-
3RXZ
-
?
D:
[13-285]
-----------------------------------------------
P
A
A
P
V
S
W
P
D
G
K
T
C
A
V
A
F
T
F
D
V
D
A
E
S
P
L
L
T
T
D
P
-
A
-
F
A
-----------------
D
R
M
G
T
M
S
H
Q
A
Y
G
P
L
-
V
-
G
V
P
R
L
L
G
I
L
D
E
F
N
V
P
-
G
T
F
F
V
P
G
Y
T
A
H
R
H
P
E
P
I
R
S
I
A
R
A
G
H
E
I
A
H
H
G
Y
L
H
E
S
L
V
G
A
D
E
D
T
E
R
K
I
L
T
R
G
I
E
A
L
E
E
V
A
G
V
H
P
V
G
----
Y
R
A
P
MW
E
M
N
W
H
--
T
-
P
K
L
L
A
E
F
-
G
F
L
Y
D
-
S
T
L
M
D
S
D
-
H
P
Y
E
L
A
V
G
-----------------------
D
G
S
L
V
E
L
P
V
S
W
A
-----
L
D
D
---------------------------
W
Q
Q
Y
--
C
F
V
PDFSGT
G
L------
I
E
T
P
A
K
A
I
E
L
W
R
A
E
L
N
A
M
R
D
I
G
G
----
A
W
V
L
T
N
H
P
F
L
S
G
R
P
G
R
-
A
A
A
L
R
E
F
I
A
E
V
C
A
M
D
D
V
-
W
V
A
G
M
S
Q
I
A
E
H
V
R
A
Q
K
L
--
16
HHSearch
60.80
20%
-33
- C3 -
-
4LY4
-
PGDAE_HELPG
A:
[35-324]
--------------------------------------------------------
A
K
E
I
L
V
A
Y
G
V
D
I
D
A
V
-
A
G
W
L
G
S
Y
G
--
G
E
-----------------
D
S
P
D
D
I
S
R
G
L
F
A
G
E
-
V
-
G
I
P
R
L
L
K
L
F
K
K
Y
H
L
P
-
A
T
W
F
V
P
G
H
S
I
E
T
F
P
E
Q
M
K
M
I
V
D
A
G
H
E
V
G
A
H
G
Y
S
H
E
N
P
I
A
M
S
T
K
Q
E
E
D
V
L
L
K
S
V
E
L
I
K
D
L
T
G
K
A
P
T
G
----
Y
V
A
P
W
W
E
F
S
N
I
--
T
-
N
E
L
L
L
K
H
-
G
F
K
Y
D
-
H
S
L
M
H
N
D
F
T
P
Y
Y
V
R
V
G
D
S
W
S
K
IDYSLEAKDWMK
P
L
I
R
G
V
E
T
N
L
V
E
I
P
A
N
W
Y
-----
L
D
D
---------------------------
L
P
P
M
--
M
F
I
------
K
KSPNSFG
F
V
S
P
R
D
I
G
Q
M
W
I
D
Q
F
D
W
V
Y
R
E
M
D
--
Y
A
V
F
S
M
T
I
H
P
D
V
S
A
R
P
Q
V
-
L
L
M
H
E
K
I
I
E
H
I
N
K
H
E
G
V
-
R
W
V
T
F
N
E
I
A
D
D
F
L
K
R
N
P
R
-
7
PsiBlast_PDB
54.42
21%
-33
- C3 -
-
3QBU
-
PGDAE_HELPG
A:
[70-322]
---------------------------------------------------------------------------------------------------------------
F
A
G
E
-
V
-
G
I
P
R
L
L
K
L
F
K
K
Y
H
L
P
-
A
T
W
F
V
P
G
H
S
I
E
T
F
P
E
Q
M
K
M
I
V
D
A
G
H
E
V
G
A
H
G
Y
S
H
E
N
P
I
A
M
S
T
K
Q
E
E
D
V
L
L
K
S
V
E
L
I
K
D
L
T
G
K
A
P
T
G
Y
V
A
P
W
W
E
F
--
S
N
I
T
N
--
E
-
L
L
L
K
H
G
F
---
K
Y
D
H
S
L
M
H
N
D
F
-
T
P
Y
Y
V
R
V
G
D
-----------------
S
-
W
S
K
------
I
D
Y
S
L
E
-----
A
K
D
WMK
P
L
I
R
G
V
E
T
NLVEIPANWYLDDLPP
M
M
F
I
KK
S
P
N
SF----
G
-------
F
V
S
P
R
D
I
G
Q
M
W
I
D
Q
F
D
W
V
Y
R
E
M
D
Y
A
--
V
F
S
M
T
I
H
P
D
V
S
A
R
P
Q
V
-
L
L
M
H
E
K
I
I
E
H
I
N
K
H
E
G
V
R
W
V
T
F
N
E
I
A
D
D
F
L
K
R
N
----
8
PsiBlast_PDB
51.51
21%
-29
- C3 -
-
4LY4
-
PGDAE_HELPG
A:
[70-322]
---------------------------------------------------------------------------------------------------------------
F
A
G
E
-
V
-
G
I
P
R
L
L
K
L
F
K
K
Y
H
L
P
-
A
T
W
F
V
P
G
H
S
I
E
T
F
P
E
Q
M
K
M
I
V
D
A
G
H
E
V
G
A
H
G
Y
S
H
E
N
P
I
A
M
S
T
K
Q
E
E
D
V
L
L
K
S
V
E
L
I
K
D
L
T
G
K
A
P
T
G
Y
V
A
P
W
W
E
F
--
S
N
I
T
N
--
E
-
L
L
L
K
H
G
F
---
K
Y
D
H
S
L
M
H
N
D
F
-
T
P
Y
Y
V
R
V
G
D
-----------------
S
-
W
S
K
------
I
D
Y
S
L
E
-----
A
K
D
WMK
P
L
I
R
G
V
E
T
NLVEIPANWYLDDLPP
M
M
F
I
KK
S
P
N
SF----
G
-------
F
V
S
P
R
D
I
G
Q
M
W
I
D
Q
F
D
W
V
Y
R
E
M
D
Y
A
--
V
F
S
M
T
I
H
P
D
V
S
A
R
P
Q
V
-
L
L
M
H
E
K
I
I
E
H
I
N
K
H
E
G
V
R
W
V
T
F
N
E
I
A
D
D
F
L
K
R
N
----
20
HHSearch
40.35
11%
-36
- C3 -
-
2Y8U
-
?
B:
[36-223]
----------------------------------------------------------------------------------------------------------
A
L
T
F
D
D
G
P
S
-
E
-
Y
T
P
Q
L
L
D
L
L
S
R
Y
S
A
R
-
A
T
F
F
V
L
G
D
A
A
A
Q
N
P
G
L
L
Q
R
M
R
D
E
G
H
Q
V
G
A
H
T
Y
D
H
V
S
L
P
S
L
G
Y
D
G
I
A
S
Q
M
T
R
L
E
E
V
I
R
P
A
L
G
V
A
P
A
Y
----
M
R
P
P
YL
E
T
N
E
L
--
V
-
L
Q
V
M
R
D
L
-
D
Y
R
V
I
-
S
A
S
V
D
T
---------------------------------------------------
K
D
---------------------------
Y
E
N
Q
--------------------
D
-
A
D
A
I
I
N
T
S
F
Q
L
F
L
D
Q
L
D
A
G
G
-----
N
I
V
L
A
H
D
I
H
Y
---
W
T
V
A
S
L
A
E
R
M
L
Q
E
V
N
A
R
-
G
L
-
I
A
T
T
V
G
D
C
L
G
D
--------
28
HHSearch
38.83
14%
-4
* C3 *
-
4M1B
-
?
A:
[61-246]
-----------------------------------------------------------------------------------------------------------
F
T
F
D
I
S
W
G
D
K
-
K
A
I
P
I
L
D
T
L
K
E
R
D
I
K
N
A
T
F
F
L
S
A
A
W
A
E
R
H
P
D
V
V
E
R
I
I
K
D
G
H
E
I
G
S
M
G
Y
N
Y
T
S
Y
T
S
L
E
T
N
E
I
R
R
D
L
L
R
A
Q
D
V
F
T
K
L
G
V
K
Q
I
K
L
----
L
R
P
P
SG
D
F
N
K
A
--
T
-
L
K
I
A
E
S
L
-
G
Y
T
V
V
-
H
W
S
N
N
---------------------------------------------------
S
N
D
---------------------------
W
K
N
P
--------------------
G
-
V
N
K
I
V
----
S
T
V
S
N
N
L
K
G
-
G
----
D
-
I
V
L
L
H
A
S
D
S
A
-
L
Q
T
-
N
K
A
L
P
L
L
L
Q
K
L
K
S
D
-
G
Y
-
E
Q
I
S
V
S
Q
L
I
S
N
T
-------
30
HHSearch
38.46
10%
-21
- C3 -
-
5JP6
-
?
A:
[171-368]
---------------------------------------------------------------------------------------------------------
V
V
L
T
F
D
D
G
P
H
-
G
L
Y
T
D
A
I
L
R
A
L
K
E
V
N
A
K
-
A
M
F
F
A
T
G
K
S
V
R
T
N
P
E
A
L
K
R
V
A
A
D
G
H
V
I
G
S
H
S
I
T
------
L
T
F
D
E
A
A
A
E
V
R
G
G
H
Q
A
V
F
D
V
L
G
W
V
D
P
V
----
F
R
F
-YG
E
T
S
K
D
--
L
-
K
A
F
L
K
T
K
-
S
T
G
E
F
-
A
W
N
----------------------------------------------
I
E
-----
S
D
D
---------------------------
W
R
T
Q
--------------------
S
-
N
E
Q
L
L
A
R
V
L
A
N
----
V
E
S
Q
G
----
R
G
I
V
L
F
H
D
I
Q
---
R
R
T
-
A
E
I
M
P
Q
F
L
R
E
L
Y
N
R
-
G
Y
-
S
V
V
L
L
T
A
A
D
P
S
--------