@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VP25: (2017-11-19 )
MNVVIIGAGMGGLTTGIALKKFGHQVRIFEQTEKILPVGAAISLWSNGVKCLNYLGLTEKIAKLGGQMDDLAYVDGLTGDVMTQFSLRPLIEEVGQRPYPVARADLQNMLMDEFGRDQIYLGKKMVGLEDKADFVEVHFADGSSTQADLLIGADGTHSMTRAYVLGQQVQRRYAGYVNWNGLVEISEDLAPAQQWTTYVGEGKRASLMPVADGRFYFFLDVPLPAGLENNRDEYKKLLKQYFADWCQPVQQLIERLDPQKTNRVEIHDIEPFTQFYKGCVVILGDAAHSTTPDIGQGGCQAMEDAIYLARSLQINTLGLEDALRRYQNKRNERANELVLRARKRCDVTHMKDETVTQAWYAELRREQGGHIMQGIISNIVGNPLD
Atome Classification :
(20 SA)
--.........10........20..-.-.....30.....--.-..40-------.....-....50...--.....60........70........80........-90.......--..100-.........110---.....----.----..120.......130.......140----.----...----...150.......160.......170.......180.---...-------------..------------.-------190----.-...----....200-........210-------.------.-------.....--------------220...--..--.------.----230-----------.--.------......240---.---..---....--250.....-.-.260.......-270.......280.......290.......300.......310...-----.-...320.......330.......340.......350.......360.......370...--....380...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--
M
N
V
V
I
IGAGMGG
L
T
T
G
I
A
L
K
KFG-
H
-
Q
V
R
I
F
E
Q
T
E
KIL--P-V
G
A
--------
A
I
S
L
W
-S
N
G
V
K
C
L
N
Y--LG
L
T
E
K
I
A
K
LGGQMDD
L
A
Y
VDGL
T
G
D
V
M
T
QF
S
L
R
P
-
L
-
I
E
E
VGQR--PYP---
V
A
R
A
D
L
Q
N
M
L
M
----
D
E
FGR----D----
Q
I
Y
LG
K
K
MVGLEDKA
D
F
V
E
V
H
FADG----S----STQ----A
D
L
L
I
GADGT
H
S
M
T
R
A
Y
V
L
G
Q
Q
V
Q
R
R
YAGYVNWN
G
L
V
---
E
I
S
-------------
E
D------------L-------A
P
-----
A
-
Q
Q
W
----
T
T
Y
VGE--GKRA
S
L
M
PVAD-------G------
R
-------
F
Y
F
F
L
--------------DVPLPA--GL--E------N----
N
R
------------
D
--
E
------
Y
K
K
L
L
K
Q
Y
F
---
A
---
D
W
---
C
Q
P
V
--
Q
Q
L
I
E
RLD-P-QKT
N
R
V
E
I
HDI-
E
P
F
T
Q
F
YKG
C
V
V
I
L
GDAAHSTTPDIGQ
G
G
C
Q
A
M
E
D
A
I
Y
L
A
R
S
L
Q
I
N
-----T-L
G
L
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D
A
L
R
R
Y
Q
N
K
R
N
E
R
A
N
E
L
V
L
R
A
R
K
RCDVTHMK
D
E
T
V
T
Q
A
W
Y
A
E
L
R
R
EQG
G
H
I
M
Q
G
I
--
I
S
N
IVGNPLD
87
HHSearch
79.47
56%
-98
* C2 *
-
3RP6
1
HPXO_KLEP7
A:
[24-407]
--
M
K
A
I
V
I
G
A
G
I
G
G
L
S
A
A
V
A
L
K
Q
S
G
-
I
-
D
C
D
V
Y
E
A
V
K
E
I
K
------
A
--------
A
I
S
V
W
-
P
N
G
V
K
C
M
A
H
--
L
G
M
G
D
I
M
E
T
F
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G
P
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R
R
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E
N
M
T
Q
F
S
L
A
P
-
L
-
I
E
R
T
G
S
R
--
P
C
P
---
V
S
R
A
E
L
Q
R
E
M
L
----
D
Y
W
G
R
----
D
----
S
V
Q
F
G
K
R
V
T
R
C
E
E
D
A
D
G
V
T
V
W
F
T
D
G
----
S
----
S
A
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----
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D
L
L
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A
A
D
G
S
H
S
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L
R
P
W
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L
G
F
T
P
Q
R
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Y
A
G
Y
V
N
W
N
G
L
V
---
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I
D
-------------
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A
------------
L
-------
A
P
-----
G
-
D
Q
W
----
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T
F
V
G
E
--
G
K
R
V
S
L
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S
A
-------
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------
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-------
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Y
F
F
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--------------
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V
P
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A
--
G
L
--
A
------
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----
D
R
------------
D
--
T
------
L
R
A
D
L
S
R
Y
F
---
A
---
G
W
---
A
P
P
V
--
Q
K
L
I
A
A
L
D
-
P
-
Q
T
T
N
R
I
E
I
H
D
I
-
E
P
F
S
R
L
V
R
G
R
V
A
L
L
G
D
A
G
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S
T
T
P
D
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G
Q
G
G
C
A
A
M
E
D
A
V
V
L
G
A
V
F
R
Q
T
-----
R
--
D
I
A
A
A
L
R
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Y
E
A
Q
R
C
D
R
V
R
D
L
V
L
K
A
R
K
R
C
D
I
T
H
G
K
D
M
Q
L
T
E
A
W
Y
Q
E
L
R
E
E
T
G
E
R
I
I
N
G
M
--
C
D
T
I
L
S
G
P
L
G
1
PsiBlast_PDB
79.36
56%
-98
- C2 -
-
3RP8
1
HPXO_KLEP7
A:
[24-406]
--
M
K
A
I
V
I
G
A
G
I
G
G
L
S
A
A
V
A
L
K
Q
S
G
-
I
-
D
C
D
V
Y
E
A
V
K
E
I
-------
A
--------
A
I
S
V
W
-
P
N
G
V
K
C
M
A
H
--
L
G
M
G
D
I
M
E
T
F
G
G
P
L
R
R
M
A
Y
R
D
F
R
S
G
E
N
M
T
Q
F
S
L
A
P
-
L
-
I
E
R
T
G
S
R
--
P
C
P
---
V
S
R
A
E
L
Q
R
E
M
L
----
D
Y
W
G
R
----
D
----
S
V
Q
F
G
K
R
V
T
R
C
E
E
D
A
D
G
V
T
V
W
F
T
D
G
----
S
----
S
A
S
----
G
D
L
L
I
A
A
D
G
S
H
S
A
L
R
P
W
V
L
G
F
T
P
Q
R
R
Y
A
G
Y
V
N
W
N
G
L
V
---
E
I
D
-------------
E
A
------------
L
-------
A
P
-----
G
-
D
Q
W
----
T
T
F
V
G
E
--
G
K
Q
V
S
L
M
P
V
S
A
-------
G
------
R
-------
F
Y
F
F
F
--------------
D
V
P
L
P
A
--
G
L
--
A
------
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----
D
R
------------
D
--
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------
L
R
A
D
L
S
R
Y
F
---
A
---
G
W
---
A
P
P
V
--
Q
K
L
I
A
A
L
D
-
P
-
Q
T
T
N
R
I
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I
H
D
I
-
E
P
F
S
R
L
V
R
G
R
V
A
L
L
G
D
A
G
H
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T
T
P
D
I
G
Q
G
G
C
A
A
M
E
D
A
V
V
L
G
A
V
F
R
-
Q
-----
T
-
R
D
I
A
A
A
L
R
E
Y
E
A
Q
R
C
D
R
V
R
D
L
V
L
K
A
R
K
R
C
D
I
T
H
G
K
D
M
Q
L
T
E
A
W
Y
Q
E
L
R
E
E
T
G
E
R
I
I
N
G
M
--
C
D
T
I
L
S
G
P
L
-
88
HHSearch
79.09
56%
-98
- C2 -
-
3RP8
1
HPXO_KLEP7
A:
[24-406]
--
M
K
A
I
V
I
G
A
G
I
G
G
L
S
A
A
V
A
L
K
Q
S
G
-
I
-
D
C
D
V
Y
E
A
V
K
E
I
-------
A
--------
A
I
S
V
W
-
P
N
G
V
K
C
M
A
H
--
L
G
M
G
D
I
M
E
T
F
G
G
P
L
R
R
M
A
Y
R
D
F
R
S
G
E
N
M
T
Q
F
S
L
A
P
-
L
-
I
E
R
T
G
S
R
--
P
C
P
---
V
S
R
A
E
L
Q
R
E
M
L
----
D
Y
W
G
R
----
D
----
S
V
Q
F
G
K
R
V
T
R
C
E
E
D
A
D
G
V
T
V
W
F
T
D
G
----
S
----
S
A
S
----
G
D
L
L
I
A
A
D
G
S
H
S
A
L
R
P
W
V
L
G
F
T
P
Q
R
R
Y
A
G
Y
V
N
W
N
G
L
V
---
E
I
D
-------------
E
A
------------
L
-------
A
P
-----
G
-
D
Q
W
----
T
T
F
V
G
E
--
G
K
Q
V
S
L
M
P
V
S
A
-------
G
------
R
-------
F
Y
F
F
F
--------------
D
V
P
L
P
A
--
G
L
--
A
------
E
----
D
R
------------
D
--
T
------
L
R
A
D
L
S
R
Y
F
---
A
---
G
W
---
A
P
P
V
--
Q
K
L
I
A
A
L
D
-
P
-
Q
T
T
N
R
I
E
I
H
D
I
-
E
P
F
S
R
L
V
R
G
R
V
A
L
L
G
D
A
G
H
S
T
T
P
D
I
G
Q
G
G
C
A
A
M
E
D
A
V
V
L
G
A
V
F
R
Q
T
-----
R
--
D
I
A
A
A
L
R
E
Y
E
A
Q
R
C
D
R
V
R
D
L
V
L
K
A
R
K
R
C
D
I
T
H
G
K
D
M
Q
L
T
E
A
W
Y
Q
E
L
R
E
E
T
G
E
R
I
I
N
G
M
--
C
D
T
I
L
S
G
P
L
-
3
PsiBlast_PDB
78.79
55%
-101
- C2 -
-
3RP7
2
HPXO_KLEP7
A:
[25-406]
---
K
A
I
V
I
G
A
G
I
G
G
L
S
A
A
V
A
L
K
Q
S
G
-
I
-
D
C
D
V
Y
E
A
V
K
E
I
K
------
A
--------
A
I
S
V
W
-
P
N
G
V
K
C
M
A
H
--
L
G
M
G
D
I
M
E
T
F
G
G
P
L
R
R
M
A
Y
R
D
F
R
S
G
E
N
M
T
Q
F
S
L
A
P
-
L
-
I
E
R
T
G
S
R
--
P
C
P
---
V
S
R
A
E
L
Q
R
E
M
L
----
D
Y
W
G
R
----
D
----
S
V
Q
F
G
K
R
V
T
R
C
E
E
D
A
D
G
V
T
V
W
F
T
D
G
----
S
----
S
A
S
----
G
D
L
L
I
A
A
D
G
S
H
S
A
L
R
P
W
V
L
G
F
T
P
Q
R
R
Y
A
G
Y
V
N
W
N
G
L
V
---
E
I
D
-------------
E
A
------------
L
-------
A
P
-----
G
-
D
Q
W
----
T
T
F
V
G
E
--
G
K
R
V
S
L
M
P
V
S
A
-------
G
------
R
-------
F
Y
F
F
F
--------------
D
V
P
L
P
A
--
G
L
--
A
------
E
----
D
R
------------
D
--
T
------
L
R
A
D
L
S
R
Y
F
---
A
---
G
W
---
A
P
P
V
--
Q
K
L
I
A
A
L
D
-
P
-
Q
T
T
N
R
I
E
I
H
D
I
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F
S
R
L
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G
R
V
A
L
L
G
D
A
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T
P
D
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G
Q
G
G
C
A
A
M
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D
A
V
V
L
G
A
V
F
R
-
Q
-----
T
-
R
D
I
A
A
A
L
R
E
Y
E
A
Q
R
C
D
R
V
R
D
L
V
L
K
A
R
K
R
C
D
I
T
H
G
K
D
M
Q
L
T
E
A
W
Y
Q
E
L
R
E
E
T
G
E
R
I
I
N
G
M
--
C
D
T
I
L
S
G
P
L
-
2
PsiBlast_PDB
78.69
55%
-98
- C2 -
-
3RP6
1
HPXO_KLEP7
A:
[25-406]
---
K
A
I
V
I
G
A
G
I
G
G
L
S
A
A
V
A
L
K
Q
S
G
-
I
-
D
C
D
V
Y
E
A
V
K
E
I
K
------
A
--------
A
I
S
V
W
-
P
N
G
V
K
C
M
A
H
--
L
G
M
G
D
I
M
E
T
F
G
G
P
L
R
R
M
A
Y
R
D
F
R
S
G
E
N
M
T
Q
F
S
L
A
P
-
L
-
I
E
R
T
G
S
R
--
P
C
P
---
V
S
R
A
E
L
Q
R
E
M
L
----
D
Y
W
G
R
----
D
----
S
V
Q
F
G
K
R
V
T
R
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E
D
A
D
G
V
T
V
W
F
T
D
G
----
S
----
S
A
S
----
G
D
L
L
I
A
A
D
G
S
H
S
A
L
R
P
W
V
L
G
F
T
P
Q
R
R
Y
A
G
Y
V
N
W
N
G
L
V
---
E
I
D
-------------
E
A
------------
L
-------
A
P
-----
G
-
D
Q
W
----
T
T
F
V
G
E
--
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K
R
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L
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S
A
-------
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------
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-------
F
Y
F
F
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--------------
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V
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L
--
A
------
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----
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R
------------
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--
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------
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R
A
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Y
F
---
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---
G
W
---
A
P
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A
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H
D
I
-
E
P
F
S
R
L
V
R
G
R
V
A
L
L
G
D
A
G
H
S
T
T
P
D
I
G
Q
G
G
C
A
A
M
E
D
A
V
V
L
G
A
V
F
R
-
Q
-----
T
-
R
D
I
A
A
A
L
R
E
Y
E
A
Q
R
C
D
R
V
R
D
L
V
L
K
A
R
K
R
C
D
I
T
H
G
K
D
M
Q
L
T
E
A
W
Y
Q
E
L
R
E
E
T
G
E
R
I
I
N
G
M
--
C
D
T
I
L
S
G
P
L
-
6
PsiBlast_PDB
63.05
28%
0
- C- -
-
3C96
1
?
A:
[5-387]
--
I
D
I
L
I
A
G
A
G
I
G
G
L
S
C
A
L
A
L
H
Q
A
G
I
G
-
K
V
T
L
L
E
S
S
S
E
I
R
--
P
-
L
G
V
--------
G
I
N
I
Q
-
P
A
A
V
E
A
L
A
E
--
L
G
L
G
P
A
L
A
A
T
A
I
P
T
H
E
L
R
Y
I
D
Q
S
G
A
T
V
W
S
E
----
P
-
R
-
G
V
E
A
G
N
A
Y
P
Q
Y
S
---
I
H
R
G
E
L
Q
M
I
L
L
A
A
V
R
E
R
L
G
Q
----
Q
----
A
V
R
T
G
L
G
V
E
R
I
E
E
R
D
G
R
V
L
I
G
A
R
D
G
HG
K
P
Q
----
A
L
G
----
A
D
V
L
V
G
A
D
G
I
H
S
A
V
R
A
H
L
H
P
D
Q
R
P
L
S
H
G
G
I
T
M
W
R
G
V
T
---
E
F
D
-------------
R
F
------------
L
DGK
T
M
I
V
A
N
-----
D
-
E
H
W
----
S
R
L
V
A
Y
--
P
I
S
A
R
H
A
A
E
G
K
-------
S
------
L
-------
V
N
W
V
C
--------------
M
V
P
S
A
A
VG
Q
L
--
D
------
N
EADW
N
R
------------
D
--
G
------
R
L
E
D
V
L
P
F
F
---
A
---
D
W
DLG
W
F
D
I
--
R
D
L
L
T
R
---
N
-
Q
L
I
L
Q
Y
P
M
V
D
R
-
D
P
L
P
H
W
G
R
G
R
I
T
L
L
G
D
A
A
H
L
M
Y
P
M
G
A
N
G
A
S
Q
A
I
L
D
G
I
E
L
A
A
A
L
A
R
N
-----
A
--
D
V
A
A
A
L
R
E
Y
E
E
A
R
R
P
T
A
N
K
I
I
L
A
N
R
E
R
-------------------------------------------
109
HHSearch
58.28
28%
0
- C- -
-
3C96
1
?
A:
[5-387]
--
I
D
I
L
I
A
G
A
G
I
G
G
L
S
C
A
L
A
L
H
Q
A
G
-
I
G
K
V
T
L
L
E
S
S
S
E
I
R
--
P
-
L
G
V
--------
G
I
N
I
Q
-
P
A
A
V
E
A
L
A
E
--
L
G
L
G
P
A
L
A
A
T
A
I
P
T
H
E
L
R
Y
I
D
Q
-
S
G
A
T
V
W
S
E
P
R
G
--
V
-
E
A
G
N
A
Y
P
--
Q
Y
S
---
I
H
R
G
E
L
Q
M
I
L
L
----
A
A
V
R
E
R
LGQ
Q
----
A
V
R
T
G
L
G
V
E
R
I
E
E
R
D
G
R
V
L
I
G
A
R
D
G
----
H
G
K
P
Q
A
L
G
----
A
D
V
L
V
G
A
D
G
I
H
S
A
V
R
A
H
L
H
P
D
Q
R
P
L
S
H
G
G
I
T
M
W
R
G
V
T
---
E
F
D
-------------
R
F
--------------------
L
------
D
-
G
K
T
----
M
I
V
A
N
D
EH
W
S
R
L
V
A
Y
P
I
S
A
R
H
A
A
E
GK
S
------
L
-------
V
N
W
V
C
--------------
M
V
P
S
A
A
--
V
G
--
Q
LDNEAD
W
----
N
R
------------
D
--
G
------
R
L
E
D
V
L
P
F
F
---
A
---
D
W
---
D
L
G
W
--
F
D
I
R
D
L
L
T
-
R
N
Q
L
I
L
Q
Y
P
M
V
D
R
-
D
P
L
P
H
W
G
R
G
R
I
T
L
L
G
D
A
A
H
L
M
Y
P
M
G
A
N
G
A
S
Q
A
I
L
D
G
I
E
L
A
A
A
L
A
R
N
-------
A
D
V
A
A
A
L
R
E
Y
E
E
A
R
R
P
T
A
N
K
I
I
L
A
N
R
E
R
-------------------------------------------
101
HHSearch
53.01
28%
-29
- C2 -
-
5EOW
1
6HN3M_PSEPK
A:
[28-385]
--
Q
K
I
A
I
V
G
A
G
L
G
G
A
A
A
A
T
L
L
Q
Q
A
G
-
F
-
D
V
E
V
F
E
Q
A
P
A
F
T
--
R
-
L
G
A
--------
G
I
H
I
G
-
P
N
V
M
K
I
F
R
R
--
M
G
L
E
Q
K
L
E
L
M
G
S
H
P
D
F
W
F
S
R
D
G
N
T
G
D
Y
L
S
R
I
P
L
G
E
-
F
A
R
R
E
Y
G
A
A
--
Y
I
T
---
I
H
R
G
D
L
H
A
L
Q
I
----
E
A
I
Q
P
----
G
----
T
V
H
F
G
K
R
L
E
K
I
----
D
Q
V
R
L
D
F
A
D
G
----
T
----
H
T
V
----
A
D
I
V
I
G
A
D
G
I
H
S
K
I
R
E
E
L
L
G
A
E
A
-
P
-
Y
S
G
W
V
A
H
R
A
L
I
---
R
----------------
Q
------------
H
-------
A
D
-----
V
F
E
P
C
----
V
K
W
W
S
E
--
D
R
H
M
M
V
Y
Y
T
T
G
KR-----
D
------
E
-------
Y
Y
F
V
T
--------------
G
V
P
H
---------------------
V
------------
D
--
S
------
S
Q
E
E
M
R
A
A
F
---
E
---
G
Y
---
H
P
T
V
--
Q
K
L
I
D
A
T
E
----
S
I
T
K
W
P
L
R
N
R
-
N
P
L
P
L
W
S
R
G
R
L
V
L
L
G
D
A
C
H
P
M
K
P
H
M
A
Q
G
A
C
M
A
I
E
D
A
A
M
L
T
R
C
L
Q
E
T
-----
G
L
S
D
H
R
T
A
F
A
L
Y
E
A
N
R
K
E
R
A
S
Q
V
Q
S
V
S
N
A
N
T
W
L
Y
S
Q
E
D
-----------------------------------
90
HHSearch
51.36
24%
-24
- C2 -
-
4BJZ
2
?
A:
[7-364]
--
A
R
I
I
I
A
G
G
G
I
G
G
A
A
N
A
L
A
L
A
Q
K
G
-
A
-
N
V
T
L
F
E
R
A
S
E
F
G
--
E
-
V
G
A
--------
G
L
Q
V
G
-
P
H
G
A
R
I
L
D
S
--
W
G
V
L
D
D
V
L
S
R
A
F
L
P
K
N
I
V
F
R
D
A
I
T
A
E
V
L
T
K
I
D
L
G
S
E
F
-
R
G
R
Y
G
G
P
--
Y
F
V
---
T
H
R
S
D
L
H
A
T
L
V
----
D
A
A
R
A
A
G
--
A
----
E
L
H
T
G
V
T
V
T
D
V
I
T
E
G
D
K
A
I
V
S
T
D
D
G
----
R
----
T
H
E
----
A
D
I
A
L
G
M
D
G
L
K
S
R
L
R
E
K
I
S
G
D
E
--
P
V
S
S
G
Y
A
A
Y
R
G
T
T
---
P
Y
R
-------------
D
V
E-----------
L
-------
D
E
D----
I
-
E
D
V
----
V
G
Y
I
G
P
--
R
C
H
F
I
Q
Y
P
L
R
G
-------
G
------
E
-------
M
L
N
Q
V
--------------
A
V
F
E
S
P
--
G
F
--
K
------
N
----
G
I
------------
E
NW
G
------
G
P
E
E
L
E
Q
A
Y
---
A
---
H
C
---
H
E
N
V
--
R
R
G
I
D
Y
L
W
----
K
D
R
W
W
P
M
Y
D
R
-
E
P
I
E
N
W
V
D
G
R
M
I
L
L
G
D
A
A
H
P
P
L
Q
Y
L
A
S
G
A
V
M
A
I
E
D
A
K
C
L
A
D
Y
A
A
E
D
FSTGG
N
-
S
A
W
P
Q
I
L
K
E
V
N
T
E
R
A
P
R
C
N
R
I
L
T
T
G
R
M
W
G
E
L
W
H
L
-------------------------------------
89
HHSearch
50.87
24%
-26
- C2 -
-
5HYM
2
?
A:
[7-364]
--
A
R
I
I
I
A
G
G
G
I
G
G
A
A
N
A
L
A
L
A
Q
K
G
-
A
-
N
V
T
L
F
E
R
A
S
E
F
G
--
E
-
V
G
A
--------
G
L
Q
V
G
-
P
H
G
A
R
I
L
D
S
--
W
G
V
L
D
D
V
L
S
R
A
F
L
P
K
N
I
V
F
R
D
A
I
T
A
E
V
L
T
K
I
D
L
G
S
E
F
-
R
G
R
Y
G
G
P
--
Y
F
V
---
T
H
R
S
D
L
H
A
T
L
V
----
D
A
A
R
A
A
G
--
A
----
E
L
H
T
G
V
T
V
T
D
V
I
T
E
G
D
K
A
I
V
S
T
D
D
G
----
R
----
T
H
E
----
A
D
I
A
L
G
M
D
G
L
K
S
R
L
R
E
K
I
S
G
D
E
--
P
V
S
S
G
Y
A
A
Y
R
G
T
T
---
P
Y
R
-------------
D
V
E-----------
L
-------
D
E
D----
I
-
E
D
V
----
V
G
Y
I
G
P
--
R
C
H
F
I
Q
Y
P
L
R
G
-------
G
------
E
-------
M
L
N
Q
V
--------------
A
V
F
E
S
P
--
G
F
--
K
------
N
----
G
I
------------
E
NW
G
------
G
P
E
E
L
E
Q
A
Y
---
A
---
H
C
---
H
E
N
V
--
R
R
G
I
D
Y
L
W
----
K
D
R
W
W
P
M
Y
D
R
-
E
P
I
E
N
W
V
D
G
R
M
I
L
L
G
D
A
A
H
P
P
L
Q
Y
L
A
S
G
A
V
M
A
I
E
D
A
K
C
L
A
D
Y
A
A
E
D
F
S
T
GG
N
-
S
A
W
P
Q
I
L
K
E
V
N
T
E
R
A
P
R
C
N
R
I
L
T
T
G
R
M
W
G
E
L
W
H
L
-------------------------------------
94
HHSearch
50.14
20%
-69
- C2 -
-
5TUI
2
?
B:
[26-406]
--
I
K
I
L
V
I
G
V
G
V
A
G
P
A
V
A
Y
W
L
K
R
F
G
-
F
-
S
P
V
L
I
E
K
S
A
A
V
R
--
K
-
G
G
Q
--------
A
L
D
I
R
-
G
I
A
T
H
I
A
K
E
--
M
G
I
Y
D
Q
I
C
N
M
R
T
Q
I
K
C
G
R
Y
V
D
V
-
K
G
N
V
L
H
E
E
Q
G
E
T
-
F
--
G
F
R
Q
D
D
--
E
V
E
---
I
L
R
G
D
L
V
E
I
L
M
----
K
A
I
A
D
----
I
----
P
C
E
F
K
Q
S
V
I
K
I
E
Q
N
E
D
S
V
T
V
T
Y
K
D
G
----
R
----
V
E
N
----
Y
D
L
V
I
A
A
D
G
I
H
S
A
T
R
G
M
V
F
S
K
N
E
-
Y
Q
L
I
N
L
G
S
Y
V
S
A
F
---
T
I
P
-------------
N
Y
--------------------
L
G
-----
L
-
D
H
M
----
E
L
L
C
E
S
--
N
-
H
K
L
V
T
L
Q
S
D
SQA----
D
------
K
-------
A
M
A
G
F
--------------
M
F
R
S
K
-------------------
D
E
------------
Q
--
E
------
Q
K
H
F
L
H
A
S
F
---
Q
---
N
F
---
G
W
E
T
--
Q
N
I
L
N
R
M
P
-
E
-
S
D
D
F
Y
F
D
A
I
T
Q
-
I
K
M
K
S
W
T
K
G
R
I
A
L
I
G
D
A
A
Y
C
P
S
P
L
S
G
Q
G
N
N
L
A
F
V
G
A
Y
I
L
A
G
E
L
K
K
A
-----
D
-
G
D
Y
I
Q
A
F
T
R
Y
N
E
L
L
H
P
F
V
E
A
N
Q
Q
F
G
V
W
V
S
E
S
------------
S
K
E
I
A
E
A
R
S
N
K
I
L
A
M
I
K
S
V
S
N
S
I
N
L
P
--
5
PsiBlast_PDB
49.71
28%
-2
- C2 -
-
2RGJ
1
?
A:
[5-368]
--
I
D
I
L
I
A
G
A
G
I
G
G
L
S
C
A
L
A
L
H
Q
A
G
I
G
-
K
V
T
L
L
E
S
S
S
E
I
R
--
P
-
L
G
V
--------
G
I
N
I
Q
-
P
A
A
V
E
A
L
A
E
--
L
G
L
G
P
A
L
A
A
T
A
I
P
T
H
E
L
R
Y
I
D
Q
S
G
A
T
V
W
S
E
----
P
-
R
-
G
V
E
A
G
N
A
YP
Q
Y
S
---
I
H
R
G
E
L
Q
M
I
L
L
A
A
V
R
E
R
L
G
Q
----
Q
----
A
V
R
T
G
L
G
V
E
R
I
E
E
R
D
G
R
V
L
I
G
A
R
D
G
----
H
----
G
K
P
Q
A
L
G
A
D
V
L
V
G
A
D
G
I
H
S
A
V
R
A
H
L
H
P
D
Q
R
P
L
S
H
G
G
I
T
M
W
R
G
V
T
---
E
F
D
-------------
R
F
------------
L
DGK
T
M
I
V
A
N
-----
D
-
E
H
W
----
S
R
L
V
A
Y
--
P
I
S
A
R
H
A
A
E
G
K
-------
S
------
L
-------
V
N
W
V
C
--------------
M
V
P
S
A
A
VG
Q
L
--
D
------
N
EADW
N
R
------------
D
--
G
------
R
L
E
D
V
L
P
F
F
---
A
---
D
W
DLG
W
F
D
I
--
R
D
L
L
T
R
---
N
-
Q
L
I
L
Q
Y
P
M
V
D
R
-
D
P
L
P
H
W
G
R
G
R
I
T
L
L
G
D
A
A
H
L
M
Y
P
M
G
A
N
G
A
S
Q
A
I
L
D
G
I
E
L
A
A
A
L
A
R
N
-----
A
--
D
V
A
A
A
L
R
E
Y
E
E
A
R
R
P
T
A
N
K
I
I
L
A
N
R
E
R
-------------------------------------------
93
HHSearch
49.70
20%
-56
- C2 -
-
5TUF
2
?
A:
[26-406]
--
I
K
I
L
V
I
G
V
G
V
A
G
P
A
V
A
Y
W
L
K
R
F
G
-
F
-
S
P
V
L
I
E
K
S
A
A
V
R
--
K
-
G
G
Q
--------
A
L
D
I
R
-
G
I
A
T
H
I
A
K
E
--
M
G
I
Y
D
Q
I
C
N
M
R
T
Q
I
K
C
G
R
Y
V
D
V
-
K
G
N
V
L
H
E
E
Q
G
E
T
-
F
--
G
F
R
Q
D
D
--
E
V
E
---
I
L
R
G
D
L
V
E
I
L
M
----
K
A
I
A
D
----
I
----
P
C
E
F
K
Q
S
V
I
K
I
E
Q
N
E
D
S
V
T
V
T
Y
K
D
G
----
R
----
V
E
N
----
Y
D
L
V
I
A
A
D
G
I
H
S
A
T
R
G
M
V
F
S
K
N
E
-
Y
Q
L
I
N
L
G
S
Y
V
S
A
F
---
T
I
P
-------------
N
Y
--------------------
L
G
-----
L
-
D
H
M
----
E
L
L
C
E
S
--
N
-
H
K
L
V
T
L
Q
S
D
SQA----
D
------
K
-------
A
M
A
G
F
--------------
M
F
R
S
K
H
--
V
L
ED
I
------
R
----
D
E
------------
Q
--
E
------
Q
K
H
F
L
H
A
S
F
---
Q
---
N
F
---
G
W
E
T
--
Q
N
I
L
N
R
M
P
-
E
-
S
D
D
F
Y
F
D
A
I
T
Q
-
I
K
M
K
S
W
T
K
G
R
I
A
L
I
G
D
A
A
Y
C
P
S
P
L
S
G
Q
G
N
N
L
A
F
V
G
A
Y
I
L
A
G
E
L
K
K
A
-----
D
-
G
D
Y
I
Q
A
F
T
R
Y
N
E
L
L
H
P
F
V
E
A
N
Q
Q
F
G
V
W
V
S
E
S
F
L
L
K
D
D
----
E
V
S
K
E
I
A
E
A
R
S
N
K
I
L
A
M
I
K
S
V
S
N
S
I
N
L
P
--
105
HHSearch
49.65
23%
-8
- C2 -
-
2VOU
2
DHPH_PAENI
A:
[6-367]
--
D
R
I
A
V
V
G
G
S
I
S
G
L
T
A
A
L
M
L
R
D
A
G
-
V
-
D
V
D
V
Y
E
R
S
P
Q
P
L
S-
G
-
F
G
T
--------
G
I
V
V
Q
-
P
E
L
V
H
Y
L
L
E
--
Q
G
V
E
L
D
S
--
I
S
V
P
S
S
S
M
E
Y
V
D
A
L
T
G
E
R
V
G
S
V
-----------
P
A
D
--
W
R
F
---
T
S
Y
D
S
I
Y
G
G
L
Y
----
E
L
F
G
P
----
E
----
R
Y
H
T
S
K
C
L
V
G
L
S
Q
D
S
E
T
V
Q
M
R
F
S
D
G
----
T
----
K
A
E
----
A
N
W
V
I
G
A
D
G
G
A
S
V
V
R
K
R
L
L
G
I
E
P
--
T
Y
A
G
Y
V
T
W
R
G
V
L
---
Q
P
G
-------------
E
V
------------
A
-------
D
D
V
W
N
Y
F
N
-
D
K
F
----
T
Y
G
L
L
D
--
D
G
H
L
I
A
Y
P
I
P
G
-------
R
ENA
E
S
P
R
L
N
-----
F
Q
W
Y
W
--------------
N
V
A
E
G
P
--
D
L
--
D
E
L
M
---
T
----
D
V
RGIRLPTSVHNN
S
--
L
------
N
P
H
N
L
R
Q
F
H
S
K
G
E
---
S
L
---
F
K
P
F
--
R
D
L
V
L
N
A
S
----
S
P
F
V
T
V
V
A
-
D
-
A
T
V
D
R
M
V
H
G
R
V
L
L
I
G
D
A
A
V
T
P
R
P
H
A
A
A
G
G
A
K
A
S
D
D
A
R
T
L
A
E
V
F
T
K
N
-------
H
D
L
R
G
S
L
Q
S
W
E
T
R
Q
L
Q
Q
G
H
A
Y
L
N
K
V
K
K
M
A
S
R
----------------------------------------
104
HHSearch
49.63
23%
-7
- C2 -
-
2VOU
2
DHPH_PAENI
C:
[6-367]
--
D
R
I
A
V
V
G
G
S
I
S
G
L
T
A
A
L
M
L
R
D
A
G
-
V
-
D
V
D
V
Y
E
R
S
P
Q
P
L
S-
G
-
F
G
T
--------
G
I
V
V
Q
-
P
E
L
V
H
Y
L
L
E
--
Q
G
V
E
L
D
S
--
I
S
V
P
S
S
S
M
E
Y
V
D
A
L
T
G
E
R
V
G
S
V
-----------
P
A
D
--
W
R
F
---
T
S
Y
D
S
I
Y
G
G
L
Y
----
E
L
F
G
P
----
E
----
R
Y
H
T
S
K
C
L
V
G
L
S
Q
D
S
E
T
V
Q
M
R
F
S
D
G
----
T
----
K
A
E
----
A
N
W
V
I
G
A
D
G
G
A
S
V
V
R
K
R
L
L
G
I
E
P
--
T
Y
A
G
Y
V
T
W
R
G
V
L
---
Q
P
G
-------------
E
V
------------
A
-------
D
D
VWNYF
N
-
D
K
F
----
T
Y
G
L
L
D
--
D
G
H
L
I
A
Y
P
I
P
G
-------
R
ENAESP
R
LN-----
F
Q
W
Y
W
--------------
N
V
A
E
G
P
--
D
L
--
D
ELM---
T
----
D
V
RGIRLPTSVHNN
S
--
L
------
N
P
H
N
L
R
Q
F
H
SKG
E
---
S
L
---
F
K
P
F
--
R
D
L
V
L
N
A
S
----
S
P
F
V
T
V
V
A
-
D
-
A
T
V
D
R
M
V
H
G
R
V
L
L
I
G
D
A
A
V
T
P
R
P
H
A
A
A
G
G
A
K
A
S
D
D
A
R
T
L
A
E
V
F
T
K
N
-------
H
D
L
R
G
S
L
Q
S
W
E
T
R
Q
L
Q
Q
G
H
A
Y
L
N
K
V
K
K
M
A
S
R
----------------------------------------
103
HHSearch
48.49
19%
-85
- C2 -
-
5TUL
-
?
A:
[26-373]
--
K
K
I
L
V
I
G
A
S
I
A
G
P
A
L
C
Y
W
L
N
H
Y
G
-
F
-
Q
P
T
L
V
E
K
N
Q
S
T
R
--
K
-
G
G
Y
--------
A
I
D
L
R
-
G
I
A
V
D
V
A
K
Q
--
M
G
I
Y
D
S
V
C
A
M
R
T
S
L
Q
C
V
R
Y
V
D
A
-
A
G
N
L
L
F
E
E
H
------------
D
--
E
V
E
---
I
V
R
G
D
L
V
D
I
L
M
----
K
T
I
T
D
----
I
----
P
C
F
Y
D
H
A
I
E
S
L
T
Q
H
D
D
H
V
T
V
Q
F
K
N
G
----
K
----
T
E
N
----
Y
D
L
V
I
A
A
D
G
L
H
S
A
T
R
R
M
V
F
S
K
D
D
-
Y
H
L
R
N
L
G
C
Y
I
S
V
F
---
S
I
P
-------------
N
Y
------------
L
--------
Q
-----
L
-
D
H
C
----
E
T
L
L
E
A
--
K
Q
K
L
V
S
I
T
S
D
K
-------
D
ST----
K
-------
A
F
A
G
F
--------------
M
F
R
S
S
N
SP
N
Y
--
I
------
R
----
D
E
------------
A
--
S
------
Q
K
D
F
L
R
E
N
F
---
T
---
N
H
---
G
W
E
S
--
N
K
L
L
S
L
M
N
-
D
-
A
N
D
F
Y
F
D
A
I
M
Q
-
V
K
M
K
D
W
T
K
G
R
I
A
L
V
G
D
A
G
Y
T
P
S
P
L
S
G
Q
G
T
S
L
A
L
V
G
A
Y
I
L
A
G
E
L
K
T
A
-----
T
--
D
H
V
A
A
F
A
R
Y
N
E
L
L
K
P
Y
V
E
A
N
Q
A
F
G
V
W
V
S
E
S
F
L
--------------------------------------
97
HHSearch
46.67
23%
8
- C2 -
-
3P9U
1
?
A:
[7-368]
--
K
N
V
A
I
I
G
G
G
P
V
G
L
T
M
A
K
L
L
Q
Q
N
G
-
I
-
D
V
S
V
Y
E
R
D
N
D
R
E
A
R
I
-
F
G
G
--------
T
L
D
L
H
K
G
S
G
Q
E
A
M
K
K
--
A
G
L
L
Q
T
Y
Y
D
L
A
L
P
-
M
G
V
N
I
A
D
-
K
K
G
N
I
L
S
T
K
N
V
K
-----
P
E
N
R
F
D
--
N
P
E
---
I
N
R
N
D
L
R
A
I
L
L
----
N
S
L
E
N
----
D
----
T
V
I
W
D
R
K
L
V
M
L
E
P
G
K
K
K
W
T
L
T
F
E
N
K
----
P
----
S
E
T
----
A
D
L
V
I
L
A
N
G
G
M
S
K
V
R
K
F
V
T
D
T
E
V
--
E
E
T
G
T
F
N
I
Q
A
D
I
---
H
Q
P
-------------
E
I
N-----------
C
-------
P
G
-----
F
F
Q
L
C
N
G
N
R
L
M
A
S
H
Q
--
G
N
L
L
F
A
N
P
N
N
N
-------
G
------
A
-------
L
H
F
G
I
--------------
S
F
K
T
P
D
--
E
W
--
K
NQVDF-
Q
----
N
R
------------
N
--
S
------
V
V
D
F
L
L
K
K
F
---
S
---
D
W
---
D
E
R
Y
--
K
E
L
I
H
T
T
L
-
S
-
F
V
G
L
A
T
R
I
F
P
L
E
K
P
W
K
S
K
R
P
L
P
I
T
M
I
G
D
A
A
H
L
M
P
P
F
A
G
Q
G
V
N
S
G
L
V
D
A
L
I
L
S
D
N
L
A
D
G
K----
F
-
N
S
I
E
E
A
V
K
N
Y
E
Q
Q
M
F
I
Y
G
K
E
A
Q
E
E
S
T
Q
N
E
I
E
M
F
K
P
------------------------------------
110
Fugue
46.54
26%
14
- C2 -
-
3C96
1
?
A:
[4-403]
-P
I
D
I
L
I
A
G
A
G
I
G
G
L
S
C
A
L
A
L
H
Q
A
G
I
G
-
K
V
T
L
L
E
S
S
S
E
I
R
--
P
-
L
G
V
--------
G
I
N
I
Q
-
P
A
A
V
E
A
L
A
E
--
L
G
L
G
P
A
L
A
A
T
A
I
P
T
H
E
L
R
Y
I
D
-
Q
S
G
A
T
V
W
S
E
P
R
G
--
V
-
E
A
G
N
A
Y
P
--
Q
Y
S
---
I
H
R
G
E
L
Q
M
I
L
L
----
A
A
V
R
E
----
R
LGQQ
A
V
R
T
G
L
G
V
E
R
I
E
E
R
D
G
R
V
L
I
G
A
R
D
G
HG
K
P
Q
----
A
L
G
----
A
D
V
L
V
G
A
D
G
I
H
S
A
V
R
A
H
L
H
P
D
Q
R
P
L
S
H
G
G
I
T
M
W
R
G
V
T
---
E
F
D
-------------
R
F
------------
L
-------
D
G
-----
K
-
T
M
I
----
V
A
N
D
E
H
--
W
S
R
L
V
A
Y
P
I
S
A
-------
R
------
H
A
A
E
GKSL
V
N
W
V
C
--------------
M
V
P
S
A
A
--
V
G
--
Q
------
L
----
D
N
------------
E
--
A
DWN
R
D
G
R
L
E
D
V
L
P
F
F
---
A
---
D
W
---
D
L
G
W
--
F
D
I
R
D
L
L
T
R
N
-
Q
L
I
L
Q
Y
P
M
V
D
R
-
D
P
L
P
H
W
G
R
G
R
I
T
L
L
G
D
A
A
H
L
M
Y
P
M
G
A
N
G
A
S
Q
A
I
L
D
G
I
E
L
A
A
A
L
A
R
N
-----
A
--
D
V
A
A
A
L
R
E
Y
E
E
A
R
R
P
T
A
N
K
I
I
L
A
N
R
E
R
E
K
E
E
W
A
A
A
S
R
P
E
R
P
R
L
---------------------------
112
Fugue
44.90
21%
-7
- C2 -
-
4J33
1
KMO_YEAST
A:
[22-411]
M
S
E
S
V
A
I
I
G
A
G
L
V
G
C
L
A
A
L
A
F
S
K
E
G
-
Y
-
N
V
T
L
Y
D
F
R
Q
D
P
R
--
L
-
D
T
T
KNKNLKSI
N
L
A
I
S
-
A
R
G
I
D
A
L
K
S
I
D
P
D
A
C
E
H
I
L
Q
D
M
I
P
M
K
---------
G
R
M
I
H
D
L
K
G
R
Q
-
E
-
S
Q
L
Y
G
E
A
--
I
N
S
---
I
N
R
S
V
L
N
N
S
L
L
----
D
E
L
E
K
----
S
T
T
--
E
L
K
F
G
H
K
L
V
K
I
E
W
T
D
D
K
Q
I
C
H
F
A
I
G
T
P
--
H
----
T
E
K
----
Y
D
F
V
I
G
C
D
G
A
Y
S
A
T
R
S
Q
M
Q
R
K
V
E
M
D
F
S
Q
E
Y
M
N
-
L
R
Y
I
---
E
L
Y
I
P
P
T
EEFKPNYGG
N
F
------------
A
-------
I
A
-----
P
-
D
H
L
----
H
I
W
P
R
H
--
K
F
M
L
I
A
L
A
N
S
D
-------
G
------
S
-------
F
T
S
T
F
--------------
F
G
S
K
D
Q
--
I
S
--
D
L
I
----
T
----
S
K
------------
S
--
R
------
V
R
E
F
L
I
E
N
F
---
P
---
D
I
---
I
N
I
M
D
L
D
D
A
V
K
R
F
I
-
T
-
Y
P
K
E
S
L
V
C
V
N
C
-
K
P
Y
-
D
V
P
G
G
K
A
I
L
L
G
D
A
A
H
A
M
V
P
F
Y
G
Q
G
M
N
C
G
F
E
D
V
R
I
L
M
A
L
L
K
K
H
-----
S
-
G
D
R
S
R
A
F
T
E
Y
T
Q
T
R
H
K
D
L
V
S
I
T
E
L
A
K
R
--
N
Y
K
E
M
S
H
D
V
T
S
K
R
F
L
--
L
R
K
----------------------
7
PsiBlast_PDB
44.74
22%
18
- C2 -
-
2VOU
2
DHPH_PAENI
A:
[8-363]
----
I
A
V
V
G
G
S
I
S
G
L
T
A
A
L
M
L
R
D
A
G
-
V
-
D
V
D
V
Y
E
R
S
P
Q
P
L
--
S
G
F
G
T
--------
G
I
V
V
Q
-
P
E
L
V
H
Y
L
L
E
--
Q
G
V
--
E
L
D
S
I
S
V
P
S
S
S
M
E
Y
V
D
A
L
T
G
--------------
E
R
V
G
S
V
--
P
A
D
W
R
F
T
S
Y
D
S
I
Y
G
G
L
Y
----
E
L
F
G
P
----
E
----
R
Y
H
T
S
K
C
L
V
G
L
S
Q
D
S
E
T
V
Q
M
R
F
S
D
G
----
T
----
K
A
E
----
A
N
W
V
I
G
A
D
G
G
A
S
V
V
R
K
R
L
L
G
--
I
E
P
T
Y
A
G
Y
V
T
W
R
G
V
L
Q
PG
E
V
A
-------------
D
D
V
W
N
Y
F
ND
K
F
T
Y
G
L
-------
L
D
-----
D
-
G
H
L
----
I
A
Y
P
I
P
--
G
R
E
N
A
E
S
P
R
L
N
-------
F
------
Q
-------
W
Y
W
N
V
A
E
G
P
D
L
D
E
L
M
TDVR
G
I
R
L
P
T
--
S
V
--
H
------
N
----
N
S
------------
L
--
N
------
P
H
N
-
L
R
Q
F
H
---
S
K
G
E
S
L
---
F
K
P
F
--
R
D
L
V
L
N
A
S
-
S
-
P
F
V
T
V
V
A
D
A
T
V
-
D
---
R
M
V
H
G
R
V
L
L
I
G
D
A
A
V
T
P
R
P
H
A
A
A
G
G
A
K
A
S
D
D
A
R
T
L
A
E
V
F
T
K
N
-----
H
--
D
L
R
G
S
L
Q
S
W
E
T
R
Q
L
Q
Q
G
H
A
Y
L
N
K
V
K
K
--------------------------------------------