@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VP54: (2017-11-19 )
MTMSPIIHSLLDTDLYKFTMLQVVLHKFPQTHSVYHFRCRNLEDTVYPLVDILDDLNEQLDHLCNLKYKEDELQYLRKLRFIKSDFVDYLELFQLKRRFIHASIDEEGRLDIRIEGPMVQAMMFEIFVLAIVNELYFSRIKTDEVWAEGERRLQAKLELIQQYEKAQQPNDPPFLVSDFGTRRRYSFEWQKHVVAAFHNTVPNVFRGTSNVLLAKELNITPIGTMAHEFLQAFQALDVRLRDFQKAALEMWVQEYRGDLGIALTDVVGMDAFLRDFDLYFAKLFDGLRHDSGDPYEWGDKAYAHYRKLKIDTKTKMLTFSDGLNLPKAWELHQYFKDRFQVSFGIGTNLTNDMGQTPLNIVLKLVECNGQSVAKISDSPGKTMTDNDTFLAYLRQVFQIEELDEAI
Atome Classification :
(20 SA)
.....-....10........20.....-.-..-30........40........50.-.......60........70.....-.------.------.80........90...-..----.------.-----.100---......-.-----110---------........120.......130...----------....140.-------......150......---..160.......170........180.......190.......200------......---..210.......220.......230....-..---.--------------------------------------240....---...250.....-..260....-----.-----..270........------280..-.-......290.......300....-.-..----310---.-....-.-..320----........330....-...340........350--------.-.---------.---------.----...360.....------..-----370---------.------........380.......390.......400....--------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
M
S
P
-
I
I
H
S
L
L
D
T
D
L
Y
K
F
T
M
L
Q
V
V
L
H
-K-FP-QTH
S
V
Y
H
F
R
CRNLE
D
T
V
Y
P
L
V
D
I
-
L
D
D
L
N
E
Q
L
D
H
L
CNLKY
K
E
D
E
L
Q
Y
L
-
R
------
K
------
L
R
F
I
K
S
D
F
V
D
Y
L
E
L
F
Q
-
L
K
----
R
------
R
-----
F
I
HA---SIDEEG-
R
-----
L
D
----------
I
R
IEG
P
M
V
Q
A
M
M
F
E
I
F
V
L
A
I
V
N
E
L
----------
Y
F
S
RIK
T
D
-------
E
V
W
A
E
G
E
R
-
R
L
Q
A
K
L
---
E
L
I
Q
Q
Y
E
K
AQQPND-P
P
F
L
VSDFGTR
R
R
Y
S
F
E
W
Q
K
H
V
V
A
A
F
H
NT
V
-------
P
N
V
FRG---TS
N
V
L
L
A
K
ELNITP
I
G
T
M
A
H
E
F
L
Q
A
F
Q
A
L
-
D
V
---
R
--------------------------------------
L
R
D
F
Q
K
A
---
A
L
E
M
W
V
Q
E
YRG-DLGI
A
L
T
D
V
-----
V
-----
G
M
D
A
-
F
L
R
D
F
D
L
Y
------
F
--
A
K
-
L
-
F
D
G
L
RHDSGDPYEWG
D
K
A
Y
A
H
Y
R
-
K
-
L
K
----ID----T-K
T
K
M
-
L
-
T
FSD-----GLNLP
K
A
W
E
L
H
Q
Y
F
K
-DR
F
Q
V
-
S
FGIGTNLTND--------M-G---------Q---------
T
----
P
L
N
I
V
L
K
L
V
EC------NG-----
Q
-----------
S
------
V
A
KISDSPGKTMTDN
D
T
F
L
A
Y
L
R
Q
V
F
Q
I
E
E
L
DEAI--------------------------------------------------------------------------------------------------------------
17
HHSearch
88.33
44%
-105
- C4 -
-
3OS4
7
PNCB_YERPE
A:
[5-395]
--
A
S
P
-
I
L
T
S
L
L
D
T
D
A
Y
K
L
H
M
Q
Q
A
V
F
H
-
H
-
Y
R
-
H
I
T
V
A
A
E
F
R
C
R
S
D
E
----
L
L
G
V
Y
-
A
D
E
I
R
H
Q
V
T
L
M
G
Q
L
A
L
T
S
D
E
F
I
Y
L
-
S
------
S
------
L
P
F
F
Q
D
D
Y
L
H
W
L
R
D
F
R
-
F
K
----
P
------
E
-----
Q
V
S
V
---
A
-
V
H
D
G
-
K
-----
L
D
----------
I
R
I
A
G
L
W
C
E
V
I
M
W
E
V
P
L
L
A
V
I
S
E
I
----------
V
H
R
R
R
S
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Q
-------
V
T
T
D
Q
A
V
Q
-
Q
L
R
T
K
L
---
E
Q
F
N
A
L
S
A
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I
--
D
I
-
T
H
F
K
L
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D
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T
R
R
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R
E
I
Q
H
T
V
V
S
T
L
K
D
E
F
--------
P
Y
L
V
G
---
T
S
N
Y
D
L
A
R
T
L
A
L
A
P
V
G
T
Q
A
H
E
W
F
Q
A
H
Q
Q
I
-
S
P
---
T
--------------------------------------
L
A
N
S
Q
R
V
---
A
L
Q
V
W
L
D
E
Y
P
N
-
Q
L
G
I
A
L
T
D
C
-----
I
-----
T
M
D
A
-
F
L
R
D
F
D
L
A
------
F
--
A
N
-
R
-
Y
Q
G
L
R
H
D
S
G
D
P
I
E
W
G
E
K
A
I
A
H
Y
E
-
K
-
L
G
----
I
D
----
P
-
M
K
K
V
-
L
-
V
F
S
D
-----
N
L
D
L
E
K
A
L
F
L
Y
R
H
F
Y
-
Q
R
I
K
L
-
V
F
G
I
G
T
R
L
T
C
D
--------
I
-
P
D--------
V
---------
K
----
P
L
N
I
V
I
K
L
V
E
C
------
N
D
-----
K
-----------
P
------
V
A
K
L
S
D
S
P
G
K
T
I
C
Q
D
P
A
F
V
D
Q
L
R
K
A
F
A
L
P
--------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.62
47%
-61
- C4 -
-
1YIR
-
PNCB2_PSEAE
A:
[12-399]
------
I
V
Q
N
L
L
D
T
D
F
Y
K
L
T
M
M
Q
A
V
L
H
-
N
-
Y
P
-
N
A
E
V
E
W
E
F
R
C
R
N
Q
E
D
----
L
R
L
Y
-
L
P
A
I
R
E
Q
L
E
Y
L
A
G
L
A
I
S
D
E
Q
L
A
F
L
-
E
------
R
------
I
P
F
L
A
P
D
F
I
R
F
L
G
L
F
R
-
F
N
----
P
------
R
-----
Y
V
Q
T
---
G
I
-
E
N
D
-
E
-----
F
F
----------
L
R
L
K
G
P
W
L
H
V
I
L
F
E
V
P
L
L
A
M
I
S
E
V
----------
R
-
N
R
A
R
Y
P
-------
A
A
T
V
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Q
A
R
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R
L
Q
E
K
F
---
D
W
L
R
R
E
A
S
A
E
E
L
A
G
---
F
K
M
A
D
F
G
T
R
R
R
F
S
Y
R
V
H
E
A
V
V
S
G
L
K
E
D
F
-------
P
G
C
F
V
G
---
T
S
N
V
H
L
A
R
K
L
D
L
K
P
L
G
T
M
A
H
E
W
L
M
A
H
Q
Q
L
-
G
P
---
R
--------------------------------------
L
I
D
S
Q
S
A
---
A
L
D
C
W
V
R
E
Y
R
G
-
L
L
G
I
A
L
T
D
C
-----
I
-----
T
T
D
A
-
F
L
R
D
F
D
L
Y
------
F
--
A
K
-
L
-
F
D
G
L
R
H
D
S
G
D
P
L
L
W
A
E
K
T
I
A
H
Y
L
-
K
-
L
G
----
I
D
----
P
-
L
T
K
T
-
L
-
V
F
S
D
-----
G
L
D
L
P
R
A
L
K
I
Y
R
A
L
Q
-
G
R
I
N
V
-
S
F
G
I
G
T
H
F
T
C
D
--------
L
P
G
---------
V
---------
E
----
P
M
N
I
V
V
K
M
S
A
C
------
N
G
-----
H
-----------
P
------
V
A
K
I
S
D
T
P
-------
P
D
F
I
H
Y
L
K
H
V
F
Q
V
---------------------------------------------------------------------------------------------------------------------
16
HHSearch
86.00
44%
-114
- C4 -
-
3OS4
5
PNCB_YERPE
B:
[5-368]
--
A
S
P
-
I
L
T
S
L
L
D
T
D
A
Y
K
L
H
M
Q
Q
A
V
F
H
-
H
-
Y
R
-
H
I
T
V
A
A
E
F
R
C
R
S
D
E
----
L
L
G
V
Y
-
A
D
E
I
R
H
Q
V
T
L
M
G
Q
L
A
L
T
S
D
E
F
I
Y
L
-
S
------
S
------
L
P
F
F
Q
D
D
Y
L
H
W
L
R
D
F
R
-
F
K
----
P
------
E
-----
Q
V
S
V
---
A
-
V
H
D
G
-
K
-----
L
D
----------
I
R
I
A
G
L
W
C
E
V
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M
W
E
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P
L
L
A
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I
----------
V
H
R
R
R
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-------
V
T
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Q
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Q
L
R
T
K
L
---
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Q
F
N
A
L
S
A
D
I
--
D
I
-
T
H
F
K
L
M
D
F
G
T
R
R
R
F
S
R
E
I
Q
H
T
V
V
S
T
L
K
D
E
F
--------
P
Y
L
V
G
---
T
S
N
Y
D
L
A
R
T
L
A
L
A
P
V
G
T
Q
A
H
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W
F
Q
A
H
Q
Q
I
-
S
P
---
T
--------------------------------------
L
A
N
S
Q
R
V
---
A
L
Q
V
W
L
D
E
Y
P
N
-
Q
L
G
I
A
L
T
D
C
-----
I
-----
T
M
D
A
-
F
L
R
D
F
D
L
A
------
F
--
A
N
-
R
-
Y
Q
G
L
R
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D
S
G
D
P
I
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W
G
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A
I
A
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L
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----
P
-
M
K
K
V
-
L
-
V
F
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D
-----
N
L
D
L
E
K
A
L
F
L
Y
R
H
F
Y
-
Q
R
I
K
L
-
V
F
G
I
G
T
R
L
T
C
D
--------
I
-
P
D--------
V
---------
K
----
P
L
N
I
V
I
K
L
V
E
C
------
N
D
-----
K
-----------
P
------
V
A
-----------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
84.42
47%
-43
- C4 -
-
1YIR
-
PNCB2_PSEAE
D:
[10-399]
---
E
R
-
I
V
Q
N
L
L
D
T
D
F
Y
K
L
T
M
M
Q
A
V
L
H
-
N
-
Y
P
-
N
A
E
V
E
W
E
F
R
C
R
N
Q
E
----
D
L
R
L
Y
-
L
P
A
I
R
E
Q
L
E
Y
L
A
G
L
A
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D
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Q
L
A
F
L
-
E
------
R
------
I
P
F
L
A
P
D
F
I
R
F
L
G
L
F
R
-
F
N
----
P
RYV---
Q
-----
T
G
-----
I
--
E
N
D
-
E
-----
F
F
----------
L
R
L
K
G
P
W
L
H
V
I
L
F
E
V
P
L
L
A
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I
S
E
V
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R
N
R
A
R
Y
P
A
-------
A
T
V
E
Q
A
R
E
-
R
L
Q
E
K
F
---
D
W
L
R
R
E
A
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A
E
E
L
---
A
G
F
K
M
A
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R
R
R
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Y
R
V
H
E
A
V
V
S
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K
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D
F
-------
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G
C
F
V
G
---
T
S
N
V
H
L
A
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K
L
D
L
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T
M
A
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M
A
H
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Q
L
-
G
P
---
R
--------------------------------------
L
I
D
S
Q
S
A
---
A
L
D
C
W
V
R
E
Y
R
G
-
L
L
G
I
A
L
T
D
C
-----
I
-----
T
T
D
A
-
F
L
R
D
F
D
L
Y
------
F
--
A
K
-
L
-
F
D
G
L
R
H
D
S
G
D
P
L
L
W
A
E
K
T
I
A
H
Y
L
-
K
-
L
G
----
I
D
----
P
-
L
T
K
T
-
L
-
V
F
S
D
-----
G
L
D
L
P
R
A
L
K
I
Y
R
A
L
Q
-
G
R
I
N
V
-
S
F
G
I
G
T
H
F
T
C
D
--------
L
P
G
---------
V
---------
E
----
P
M
N
I
V
V
K
M
S
A
C
------
N
G
-----
H
-----------
P
------
V
A
K
I
S
D
T
P
-------
P
D
F
I
H
Y
L
K
H
V
F
Q
V
---------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.05
42%
-5
- C4 -
-
3OS4
7
PNCB_YERPE
A:
[6-395]
---
S
P
-
I
L
T
S
L
L
D
T
D
A
Y
K
L
H
M
Q
Q
A
V
F
H
-
H
-
Y
R
-
H
I
T
V
A
A
E
F
R
C
R
S
D
E
-----
L
L
G
V
Y
A
D
E
I
R
H
Q
V
T
L
M
G
Q
L
A
L
T
S
D
E
F
I
Y
L
-
S
------
S
------
L
P
F
F
Q
D
D
Y
L
H
W
L
R
D
F
R
-
F
K
----
P
------
E
-----
Q
V
S
V
---
A
V
-
H
D
G
-
K
-----
L
D
----------
I
R
I
A
G
L
W
C
E
V
I
M
W
E
V
P
L
L
A
V
I
S
E
I
----------
V
H
R
R
R
S
T
Q
-------
V
T
T
D
Q
A
V
Q
-
Q
L
R
T
K
L
---
E
---
Q
F
N
A
L
S
A
D
I
D
I
T
H
F
K
L
M
D
F
G
T
R
R
R
F
S
R
E
I
Q
H
T
V
V
S
T
L
K
D
E
F
-------
P
Y
L
V
-
G
---
T
S
N
Y
D
L
A
R
T
L
A
L
A
P
V
G
T
Q
A
H
E
W
F
Q
A
H
Q
Q
I
-
S
P
---
T
--------------------------------------
L
A
N
S
Q
R
V
---
A
L
Q
V
W
L
D
E
Y
P
N
-
Q
L
G
I
A
L
T
D
C
-----
I
-----
T
M
D
A
-
F
L
R
D
F
D
L
A
------
F
--
A
N
-
R
-
Y
Q
G
L
R
H
D
S
G
D
P
I
E
W
G
E
K
A
I
A
H
Y
E
-
K
-
L
G
----
I
D
----
P
-
M
K
K
V
-
L
-
V
F
S
D
-----
N
L
D
L
E
K
A
L
F
L
Y
R
H
F
Y
-
Q
R
I
K
L
-
V
F
G
I
G
T
R
L
T
C
D
--------
I
-
P
---------
D
---------
V
K
---
P
L
N
I
V
I
K
L
V
E
C
------
N
D
-----
K
-----------
P
------
V
A
K
L
S
D
S
P
G
K
T
I
C
Q
D
P
A
F
V
D
Q
L
R
K
A
F
A
L
P
--------------------------------------------------------------------------------------------------------------------
14
HHSearch
78.60
39%
-25
- C4 -
-
4HL7
-
PNCB_VIBCH
A:
[8-417]
-
F
S
P
H
-
I
I
R
S
L
L
D
L
D
A
Y
K
I
N
M
M
Q
A
I
H
H
-
F
-
Y
P
-
D
V
S
V
R
Y
E
L
I
V
R
S
E
E
----
D
A
S
G
L
-
L
D
A
I
R
Q
E
I
A
H
L
G
T
L
R
F
S
D
A
D
I
H
Y
L
-
T
------
Q
H-----
A
P
H
L
K
A
T
F
L
Q
S
L
R
Y
F
H
-
F
V
----
P
QEQ
V
--
E
-----
M
G
I
V
---
K
------------
Q
Q
L
R
--------
I
S
I
R
G
S
W
R
D
T
I
L
Y
E
T
L
V
M
A
I
V
S
E
V
----------
R
S
R
Q
R
W
A
E
-------
V
P
A
D
L
P
L
K
-
V
L
K
T
K
L
---
D
Q
L
K
A
E
I
E
R
R
G
I
---
N
N
F
S
L
T
E
M
G
T
R
R
R
F
S
S
Q
V
Q
R
D
V
L
A
C
L
K
Q
E
I
-------
P
Q
W
V
L
G
---
T
S
N
Y
H
F
A
R
E
F
D
L
K
P
I
G
T
I
A
H
E
W
F
M
G
H
Q
A
L
-
V
----
N
--------------------------------------
E
R
D
S
Q
Q
V
---
A
L
E
R
W
L
T
A
F
D
G
-
M
L
A
I
A
P
T
D
T
-----
L
-----
T
I
D
A
-
F
L
N
D
F
N
R
H
------
L
--
A
N
-
A
-
Y
D
G
V
R
H
D
S
G
C
P
F
R
W
G
D
K
M
I
A
H
Y
Q
-
Q
-
L
G
----
I
D
----
P
--
T
T
K
-
L
F
I
F
S
D
-----
G
L
D
F
D
Q
A
L
E
L
C
E
Y
F
A
-
G
R
V
K
I
-
S
F
G
I
G
T
F
L
T
N
D
--------
L
-
A
NWRNAAG
V
E
Y
---------
R
----
P
L
S
I
V
I
K
L
A
E
C
------
Q
G
-----
R
-----------
P
------
V
A
K
I
S
D
Q
P
E
K
A
M
C
E
D
P
I
F
L
A
N
L
K
R
R
F
N
I
E
L
D
V
D
----------------------------------------------------------------------------------------------------------------
13
HHSearch
78.26
39%
-24
- C4 -
-
4HL7
-
PNCB_VIBCH
B:
[8-417]
-
F
S
P
H
-
I
I
R
S
L
L
D
L
D
A
Y
K
I
N
M
M
Q
A
I
H
H
-
F
-
Y
P
-
D
V
S
V
R
Y
E
L
I
V
R
S
E
E
----
D
A
S
G
L
-
L
D
A
I
R
Q
E
I
A
H
L
G
T
L
R
F
S
D
A
D
I
H
Y
L
-
T
------
Q
H-----
A
P
H
L
K
A
T
F
L
Q
S
L
R
Y
F
H
-
F
V
----
P
QEQ
V
--
E
-----
M
G
I
V
---
K
----
G
-
K
-----
Q
Q
L
R
--------
I
S
I
R
G
S
W
R
D
T
I
L
Y
E
T
L
V
M
A
I
V
S
E
V
----------
R
S
R
Q
R
W
A
E
-------
V
P
A
D
L
P
L
K
-
V
L
K
T
K
L
---
D
Q
L
K
A
E
I
E
R
R
G
I
---
N
N
F
S
L
T
E
M
G
T
R
R
R
F
S
S
Q
V
Q
R
D
V
L
A
C
L
K
Q
E
I
-------
P
Q
W
V
L
G
---
T
S
N
Y
H
F
A
R
E
F
D
L
K
P
I
G
T
I
A
H
E
W
F
M
G
H
Q
A
L
-
V
----
N
--------------------------------------
E
R
D
S
Q
Q
V
---
A
L
E
R
W
L
T
A
F
D
G
-
M
L
A
I
A
P
T
D
T
-----
L
-----
T
I
D
A
-
F
L
N
D
F
N
R
H
------
L
--
A
N
-
A
-
Y
D
G
V
R
H
D
S
G
C
P
F
R
W
G
D
K
M
I
A
H
Y
Q
-
Q
-
L
G
----
I
D
----
P
--
T
T
K
-
L
F
I
F
S
D
-----
G
L
D
F
D
Q
A
L
E
L
C
E
Y
F
A
-
G
R
V
K
I
-
S
F
G
I
G
T
F
L
T
N
D
--------
L
-
A
NWRNAAG
V
E
Y
---------
R
----
P
L
S
I
V
I
K
L
A
E
C
------
Q
G
-----
R
-----------
P
------
V
A
K
I
S
D
Q
P
E
K
A
M
C
E
D
P
I
F
L
A
N
L
K
R
R
F
N
I
E
L
D
V
D
----------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.76
38%
-3
- C4 -
-
4HL7
-
PNCB_VIBCH
A:
[9-413]
---
S
P
H
I
I
R
S
L
L
D
L
D
A
Y
K
I
N
M
M
Q
A
I
H
H
-
F
-
Y
P
-
D
V
S
V
R
Y
E
L
I
V
R
S
E
E
D
A
S
----
G
L
-
L
D
A
I
R
Q
E
I
A
H
L
G
T
L
R
F
S
D
A
D
I
H
Y
L
T
Q
------
H
------
A
P
H
L
K
A
T
F
L
Q
S
L
R
Y
F
H
F
V
P
----
Q
------
E
-----
Q
V
E
M
---
G
I
V
K
--Q
Q
-----
L
R
----------
I
S
I
R
G
S
W
R
D
T
I
L
Y
E
T
L
V
M
A
I
V
S
E
---------------
V
R
S
R
-------
Q
R
W
A
E
V
P
A
-
D
L
P
L
K
V
L
K
T
K
L
D
Q
L
K
A
E
I
E
R
R
G
I
-
N
N
F
S
L
T
E
M
G
T
R
R
R
F
S
S
Q
V
Q
R
D
V
L
A
C
L
K
Q
E
I
-------
P
Q
W
V
L
G
---
T
S
N
Y
H
F
A
R
E
F
D
L
K
P
I
G
T
I
A
H
E
W
F
M
G
H
Q
A
L
--
V
---
N
--------------------------------------
E
R
D
S
Q
Q
V
---
A
L
E
R
W
L
T
A
F
D
G
-
M
L
A
I
A
P
T
D
T
-----
L
-----
T
I
D
A
-
F
L
N
D
F
N
R
H
------
L
--
A
N
-
A
-
Y
D
G
V
R
H
D
S
G
C
P
F
R
W
G
D
K
M
I
A
H
Y
Q
-
Q
-
L
G
----
I
D
----
P
-
T
T
K
L
-
F
-
I
F
S
D
-----
G
L
D
F
D
Q
A
L
E
L
C
E
Y
F
A
-
G
R
V
K
I
-
S
F
G
I
G
T
F
L
T
N
D
--------
L
-
A
---------
N
WRNAAG
V
E
Y
R
----
P
L
S
I
V
I
K
L
A
E
C
------
Q
G
-----
R
-----------
P
------
V
A
K
I
S
D
Q
P
E
K
A
M
C
E
D
P
I
F
L
A
N
L
K
R
R
F
N
I
E
--------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.22
32%
-21
- C4 -
-
1YBE
-
PNCB_AGRFC
A:
[24-427]
--
L
D
P
-
I
V
R
S
L
I
D
T
D
F
Y
K
L
L
M
L
Q
M
I
W
K
-
L
-
Y
P
-
E
V
D
A
T
F
S
L
I
N
R
T
K
T
V
R
L
A
E
E
I
D
E
-
M
E
-
L
R
E
Q
L
D
H
A
R
T
L
R
L
S
K
K
E
N
I
W
L
-
A
G
NTFYG
R
------
S
Q
I
F
E
P
E
F
L
S
W
L
S
S
Y
Q
-
L
P
----
E
--------------
Y
E
---
L
F
K
R
D
G
-
Q
-----
Y
E
----------
L
N
F
H
G
R
W
M
D
T
T
L
W
E
I
P
A
L
S
I
I
N
E
L
R
S
R
S
A
M
R
SLG
Y
F
T
---
L
D
-------
V
L
Y
A
R
A
K
A
-
K
M
W
E
K
V
---
E
R
L
R
E
L
---------
P
G
L
R
I
S
D
F
G
T
R
R
R
H
S
F
L
W
Q
R
W
C
V
E
A
L
K
E
G
I
-------
G
P
A
F
T
G
---
T
S
N
V
L
L
A
M
D
S
D
L
E
A
V
G
T
N
A
H
E
L
P
M
V
V
A
A
L
-
A
Q
---
T
--------------------------------------
N
E
E
L
A
A
A
P
Y
Q
V
L
K
D
W
N
R
L
Y
G
G
-
N
L
L
I
V
L
P
D
A
-----
F
-----
G
T
A
A
-
F
L
R
N
A
P
E
W
------
V
--
A
D
---
W
T
G
F
R
P
D
S
A
P
P
I
E
G
G
E
K
I
I
E
W
W
R
-
K
-
M
G
----
R
D
----
P
-
R
T
K
M
-
L
-
I
F
S
D
-----
G
L
D
V
D
A
I
V
D
T
Y
R
H
F
E
-
G
R
V
R
M
-
S
F
G
W
G
T
N
L
T
N
D
--------
F
-
A
---------
G
---------
C
APLK
P
I
S
I
V
C
K
V
S
D
A
------
N
G
-----
R
-----------
P
------
A
V
K
L
S
D
N
P
Q
K
A
T
G
D
P
A
E
V
E
R
Y
L
K
--------------------------------------------------------------------------------------------------------------------------
18
HHSearch
73.93
34%
-5
- C4 -
-
2IM5
-
?
C:
[3-391]
------
I
I
R
S
I
L
D
T
D
L
Y
K
F
T
T
G
Y
A
Y
A
K
-
L
-
F
P
-
R
A
Y
G
E
F
R
F
I
D
R
N
R
Q
G
---
F
T
E
E
F
-
A
E
L
V
R
G
E
I
R
A
M
A
A
L
S
L
T
R
D
E
K
E
F
L
-
Q
------
R
E-----
L
P
Y
L
P
P
I
Y
I
D
F
L
D
G
F
R
-
F
D
----
P
------
E
-----
E
V
T
V
---
S
I
D
A
Q
G
-
H
-----
L
D
----------
I
R
A
Q
G
L
L
Y
R
V
T
L
W
E
T
P
I
L
A
V
I
S
E
L
----------
Y
Y
R
F
I
G
A
E
-------
P
D
W
K
Q
V
E
E
-
V
T
R
S
K
G
---
E
L
M
R
E
H
----------
R
A
T
F
S
I
F
G
M
R
R
R
F
S
L
E
V
E
D
R
V
T
D
I
L
K
Q
Y
A
-------
G
E
S
L
F
G
---
T
S
N
V
H
L
A
H
K
H
G
L
R
V
S
G
T
H
P
H
E
W
I
Q
F
H
G
A
I
-
Y
----
G
--------------------------------------
Y
K
M
A
N
Y
V
---
A
M
E
D
W
I
N
V
Y
D
G
-
D
L
G
T
V
L
T
D
T
-----
Y
-----
T
T
D
V
-
F
M
R
N
F
S
K
K
------
H
--
A
M
-
L
-
F
T
S
L
R
H
D
S
G
D
P
E
I
F
I
E
K
A
V
R
R
Y
E
-
E
-
L
R
----
V
D
----
P
--
K
I
K
Y
I
-
I
F
S
D
-----
S
L
T
P
Q
R
A
I
E
I
Q
K
L
C
A
-
G
R
I
K
A
-
S
F
G
I
G
T
N
L
T
N
D
--------
V
-
G
GG-------
V
---------
E
----
P
L
N
I
V
M
K
L
W
K
C
KMTAKD
D
W
-----
H
-----------
Y
------
C
V
K
L
S
D
V
D
G
K
H
T
-
G
E
P
E
E
I
L
L
A
M
N
T
L
G
I
---------------------------------------------------------------------------------------------------------------------
19
HHSearch
72.25
33%
-18
- C4 -
-
1YBE
-
PNCB_AGRFC
B:
[25-433]
---
D
P
-
I
V
R
S
L
I
D
T
D
F
Y
K
L
L
M
L
Q
M
I
W
K
-
L
-
Y
P
-
E
V
D
A
T
F
S
L
I
N
R
T
K
T
V
R
-
L
A
E
E
I
D
-
E
M
E
L
R
E
Q
L
D
H
A
R
T
L
R
L
S
K
K
E
N
I
W
L
-
A
------
G
NTFYGR
S
Q
I
F
E
P
E
F
L
S
W
L
S
S
Y
Q
-
L
------------
P
-----
E
Y
E
L
---
F
K
-
R
D
G
-
Q
-----
Y
E
----------
L
N
F
H
G
R
W
M
D
T
T
L
W
E
I
P
A
L
S
I
I
N
E
L
----------
R
S
R
S
A
M
R
S
LGYFTLD
V
L
Y
A
R
A
K
A
-
K
M
W
E
K
V
---
E
R
L
R
E
L
---------
P
G
L
R
I
S
D
F
G
T
R
R
R
H
S
F
L
W
Q
R
W
C
V
E
A
L
K
E
G
I
-------
G
P
A
F
T
G
---
T
S
N
V
L
L
A
M
D
S
D
L
E
A
V
G
T
N
A
H
E
L
P
M
V
V
A
A
L
-
A
Q
TNE
E
--------------------------------------
L
A
A
A
P
Y
Q
---
V
L
K
D
W
N
R
L
Y
G
G
-
N
L
L
I
V
L
P
D
A
-----
F
-----
G
T
A
A
-
F
L
R
N
A
P
E
-------
W
--
V
A
-
D
-
W
T
G
F
R
P
D
S
A
P
P
I
E
G
G
E
K
I
I
E
W
W
R
-
K
-
M
G
----
R
D
----
P
--
R
T
K
M
L
-
I
F
S
D
-----
G
L
D
V
D
A
I
V
D
T
Y
R
H
F
E
-
G
R
V
R
M
-
S
F
G
W
G
T
N
L
T
N
D
--------
F
A
G
---------
C
APL------
K
----
P
I
S
I
V
C
K
V
S
D
A
------
N
G
-----
R
-----------
P
------
A
V
K
L
S
D
N
P
Q
K
A
T
-
G
D
P
A
E
V
E
R
Y
L
K
F
F
G
E
E
D
-------------------------------------------------------------------------------------------------------------------
20
HHSearch
71.82
33%
-13
- C4 -
-
1VLP
1
NPT1_YEAST
C:
[16-428]
----
P
-
V
I
K
S
L
L
D
T
D
M
Y
K
I
T
M
H
A
A
V
F
T
-
N
-
F
P
-
D
V
T
V
T
Y
K
Y
T
N
R
S
S
Q
L
T
--
F
N
K
E
A
-
I
N
W
L
K
E
Q
F
S
Y
L
G
N
L
R
F
T
E
E
E
I
E
Y
L
-
K
------
Q
E-----
I
P
Y
L
P
S
A
Y
I
K
Y
I
S
S
S
N
-
Y
K
----
L
H
-----
P
-----
E
E
Q
I
---
S
--
F
T
S
-
E
-----
E
I
E
GKPT
H
Y
K
L
K
I
L
V
S
G
S
W
K
D
T
I
L
Y
E
I
P
L
L
S
L
I
S
E
A
----------
Y
F
K
F
V
D
I
D
-------
W
D
Y
E
N
Q
-
L
-
E
Q
A
E
K
K
---
A
E
T
L
F
D
---------
N
G
I
R
F
S
E
F
G
T
R
R
R
R
S
L
K
A
Q
D
L
I
M
Q
G
I
M
K
A
V
N
G
N
PDRN
K
S
L
L
L
G
---
T
S
N
I
L
F
A
K
K
Y
G
V
K
P
I
G
T
V
A
H
E
W
V
M
G
V
A
S
I
-
S
E
---
D
--------------------------------------
Y
L
H
A
N
K
N
---
A
M
D
C
W
I
N
T
F
G
A
K
N
A
G
L
A
L
T
D
T
-----
F
-----
G
T
D
D
-
F
L
K
S
F
R
P
P
------
Y
--
S
D
-
A
-
Y
V
G
V
R
Q
D
S
G
D
P
V
E
Y
T
K
K
I
S
H
H
Y
H
-
D
V
L
K
----
L
P
----
K
-
F
S
K
I
-
I
-
C
Y
S
D
-----
S
L
N
V
E
K
A
I
T
Y
S
H
A
A
K
E
N
G
M
L
A
-
T
F
G
I
G
T
N
F
T
N
D
--------
F
-
R
KKSEPQVK-
S
---------
E
----
P
L
N
I
V
I
K
L
L
E
V
------
N
G
-----
N
-----------
H
------
A
I
K
I
S
D
N
L
G
K
N
M
-
G
D
P
A
T
V
K
R
V
K
E
E
L
G
Y
T
E
-------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
71.26
32%
1
- C4 -
-
1VLP
2
NPT1_YEAST
A:
[16-416]
----
P
-
V
I
K
S
L
L
D
T
D
M
Y
K
I
T
M
H
A
A
V
F
T
-
N
-
F
P
-
D
V
T
V
T
Y
K
Y
T
N
R
S
S
Q
L
T
F
N
K
--
E
A
-
I
N
W
L
K
E
Q
F
S
Y
L
G
N
L
R
F
T
E
E
E
I
E
Y
L
-
K
------
Q
E-----
I
P
Y
L
P
S
A
Y
I
K
Y
I
S
S
S
N
-
Y
K
LHPE
E
------
Q
-----
I
S
F
T
---
S
E
E
I
E
G
-
K
PT
H
Y
K
L
K
----------
I
L
V
S
G
S
W
K
D
T
I
L
Y
E
I
P
L
L
S
L
I
S
E
A
----------
Y
F
K
F
V
D
I
D
---------
W
-
D
Y
E
N
-
Q
L
E
---------
Q
A
E
K
K
A
E
T
L
F
D
-
N
G
I
R
F
S
E
F
G
T
R
R
R
R
S
L
K
A
Q
D
L
I
M
Q
G
I
M
K
A
V
N
G
N
PDRN
K
S
L
L
L
G
---
T
S
N
I
L
F
A
K
K
Y
G
V
K
P
I
G
T
V
A
H
E
W
V
M
G
V
A
S
I
-
S
E
---
D
--------------------------------------
Y
L
H
A
N
K
N
---
A
M
D
C
W
I
N
T
F
G
A
K
N
A
G
L
A
L
T
D
T
-----
F
-----
G
T
D
D
-
F
L
K
S
F
R
P
P
------
Y
--
S
D
-
A
-
Y
V
G
V
R
Q
D
S
G
D
P
V
E
Y
T
K
K
I
S
H
H
Y
H
-
D
V
L
K
----
L
P
----
K
-
F
S
K
I
-
I
-
C
Y
S
D
-----
S
L
N
V
E
K
A
I
T
Y
S
H
A
A
K
-
E
N
G
M
L
A
T
F
G
I
G
T
N
F
T
N
D
FRKKSEPQ
V
-
K
---------
S
---------
E
----
P
L
N
I
V
I
K
L
L
E
V
------
N
G
-----
N
-----------
H
------
A
I
K
I
S
D
N
L
G
K
N
M
G
D
P
A
T
--------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
71.17
33%
-14
- C4 -
-
1VLP
2
NPT1_YEAST
B:
[16-431]
----
P
-
V
I
K
S
L
L
D
T
D
M
Y
K
I
T
M
H
A
A
V
F
T
-
N
-
F
P
-
D
V
T
V
T
Y
K
Y
T
N
R
S
S
Q
L
T
--
F
N
K
E
A
-
I
N
W
L
K
E
Q
F
S
Y
L
G
N
L
R
F
T
E
E
E
I
E
Y
L
-
K
------
Q
E
-----
I
P
Y
L
P
S
A
Y
I
K
Y
I
S
S
S
N
-
Y
K
----
L
H
-----
P
-----
E
E
Q
I
---
S
--
F
T
S
-
E
-----
E
I
EGKPT
H
Y
K
L
K
I
L
V
S
G
S
W
K
D
T
I
L
Y
E
I
P
L
L
S
L
I
S
E
A
----------
Y
F
K
F
V
D
I
D
-------
W
D
Y
E
N
Q
-
L
-
E
Q
A
E
K
K
---
A
E
T
L
F
D
---------
N
G
I
R
F
S
E
F
G
T
R
R
R
R
S
L
K
A
Q
D
L
I
M
Q
G
I
M
K
A
V
N
G
N
PDRN
K
S
L
L
L
G
---
T
S
N
I
L
F
A
K
K
Y
G
V
K
P
I
G
T
V
A
H
E
W
V
M
G
V
A
S
I
-
S
E
---
D
--------------------------------------
Y
L
H
A
N
K
N
---
A
M
D
C
W
I
N
T
F
G
A
K
N
A
G
L
A
L
T
D
T
-----
F
-----
G
T
D
D
-
F
L
K
S
F
R
P
P
------
Y
--
S
D
-
A
-
Y
V
G
V
R
Q
D
S
G
D
P
V
E
Y
T
K
K
I
S
H
H
Y
H
-
D
V
L
K
----
L
P
----
K
-
F
S
K
I
-
I
-
C
Y
S
D
-----
S
L
N
V
E
K
A
I
T
Y
S
H
A
A
K
E
N
G
M
L
A
-
T
F
G
I
G
T
N
F
T
N
D
--------
F
-
R
K
KSEPQVK-
S
---------
E
----
P
L
N
I
V
I
K
L
L
E
V
------
N
G
-----
N
-----------
H
------
A
I
K
I
S
D
N
L
G
K
N
M
-
G
D
P
A
T
V
K
R
V
K
E
E
L
G
Y
T
E
R
S
W
----------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
71.01
34%
2
- C4 -
-
2IM5
-
?
A:
[3-383]
------
I
I
R
S
I
L
D
T
D
L
Y
K
F
T
T
G
Y
A
Y
A
K
-
L
-
F
P
-
R
A
Y
G
E
F
R
F
I
D
R
N
R
Q
G
F
T
E
E
F
A
E
L
-
V
---
R
G
E
I
R
A
M
A
A
L
S
L
T
R
D
E
K
E
F
L
Q
R
------
E
------
L
P
Y
L
P
P
I
Y
I
D
F
L
D
G
F
R
-
F
D
----
P
------
E
-----
E
V
T
V
---
S
I
D
A
Q
G
-
H
-----
L
D
----------
I
R
A
Q
G
L
L
Y
R
V
T
L
W
E
T
P
I
L
A
V
I
S
E
L
----------
Y
Y
R
F
I
G
A
E
-------
P
D
W
K
Q
V
E
E
-
V
T
R
S
K
G
---
E
L
M
R
E
H
R
A
T
----------
F
S
I
F
G
M
R
R
R
F
S
L
E
V
E
D
R
V
T
D
I
L
K
Q
Y
A
-------
G
E
S
L
F
G
---
T
S
N
V
H
L
A
H
K
H
G
L
R
V
S
G
T
H
P
H
E
W
I
Q
F
H
G
A
I
Y
G
Y
---
K
--------------------------------------
M
A
N
Y
--
V
---
A
M
E
D
W
I
N
V
Y
D
G
-
D
L
G
T
V
L
T
D
T
-----
Y
-----
T
T
D
V
-
F
M
R
N
F
S
K
K
------
H
--
A
M
-
L
-
F
T
S
L
R
H
D
S
G
D
P
E
I
F
I
E
K
A
V
R
R
Y
E
-
E
-
L
R
----
V
D
----
P
-
K
I
K
Y
-
I
-
I
F
S
D
-----
S
L
T
P
Q
R
A
I
E
I
Q
K
L
C
A
-
G
R
I
K
A
-
S
F
G
I
G
T
N
L
T
N
D
--------
V
-
G
---------
G
---------
G
V
E
--
P
L
N
I
V
M
K
L
W
K
C
------
K
M
-----
T
-----------
A
KD
D
W
H
Y
C
V
K
L
S
D
V
D
G
K
H
T
G
E
P
E
E
I
L
------------------------------------------------------------------------------------------------------------------------------
35
Fugue
51.23
23%
7
- C4 -
-
2F7F
4
?
A:
[4-485]
-
T
Y
A
D
-
D
-
S
L
T
L
H
T
D
M
Y
Q
I
N
M
M
Q
T
Y
W
E
-
L
G
R
A
-
D
L
H
A
V
F
E
C
Y
F
R
E
M
P
F
N
H
G
Y
A
I
---
F
A
G
L
E
R
L
V
N
Y
L
E
N
L
T
F
T
E
S
D
I
A
Y
L
-
R
------
E
------
V
E
E
Y
P
E
D
F
L
T
Y
L
A
N
F
E
-
F
K
----
C
------
T
-----
V
R
S
A
L
EG
D
L
V
F
N
N
-
E
-----
P
L
----------
I
Q
I
E
G
P
L
A
Q
C
Q
L
V
E
T
A
L
L
N
M
V
N
F
Q
----------
T
L
I
A
T
K
A
A
-------
R
I
K
S
V
I
G
D
-
D
P
--------------------------
L
L
E
F
G
T
R
R
A
Q
E
---
L
D
A
A
I
W
G
T
R
A
A
Y
-------
I
G
G
A
D
A
---
T
S
N
V
R
A
G
K
I
F
G
I
P
V
S
G
T
H
A
H
S
L
V
Q
S
Y
G
N
--------------------------------------------------
D
Y
E
---
A
F
M
A
Y
A
K
T
H
R
---
D
C
V
F
L
V
D
T
-----
Y
DTLKA
G
V
P
S
-
A
I
R
V
A
R
E
M
------
G
--
D
K
I
N
-
F
L
G
V
R
I
D
S
G
D
M
A
Y
I
S
K
R
V
R
E
Q
L
D
-
E
-
A
G
----
F
T
----
E
-
A
--
K
-
I
-
Y
A
S
N
-----
D
L
D
E
N
T
I
L
N
L
K
M
--
Q
-
K
S
K
I
D
-
V
W
G
V
G
T
K
L
I
T
A
--------
Y
-
D
---------
Q
---------
P
----
A
L
G
A
V
F
K
L
V
S
I
------
E
G
-----
E
-----------
D
-------
G
Q
M
K
D
T
I
K
L
S
S
N
A
E
K
V
T
T
P
G
K
K
Q
V
W
R
I
T
R
K
S
D
K
K
SE
G
D
Y
V
T
L
WNEDPRQEE
E
I
Y
M
F
H
PVHTFI
N
K
Y
V
R
D
F
E
A
R
P
VLQDIFVEGKRV
Y
E
L
P
T
L
D
E
I
K
Q
Y
A
K
E
N
L
D
S
LHEEYKRDLNPQKYPVDLS
T
D
C
W
N
H
K
M
N
L
L
E
K
V
R
K
D
V
KH
26
HHSearch
49.26
24%
2
* C4 *
-
4MZY
14
?
A:
[6-370]
----
A
-
D
D
S
L
T
L
H
T
D
M
Y
Q
I
N
M
M
Q
T
Y
W
E
-
L
-
G
R
A
D
L
H
A
V
F
E
C
Y
F
R
E
M
P
F
N
--
H
G
Y
A
I
-
F
A
G
L
E
R
L
V
N
Y
L
E
N
L
T
F
T
E
S
D
I
A
Y
L
-
R
------
E
------
V
E
E
Y
P
E
D
F
L
T
Y
L
A
N
F
E
-
F
K
----
C
------
T
V
R
S
A
L
E
G
D
L
---
V
--
F
N
N
-
E
-----
P
L
----------
I
Q
I
E
G
P
L
A
Q
C
Q
L
V
E
T
A
L
L
N
M
V
N
-------------
F
Q
-------------------
T
-
L
I
A
T
K
A
---
A
R
I
K
S
V
I
--------
G
D
D
P
L
L
E
F
G
T
R
R
A
Q
E
L
D
A
---
A
I
W
G
T
R
A
A
Y
-------
I
G
G
A
D
A
---
T
S
N
V
R
A
G
K
I
F
G
I
P
V
S
G
T
H
A
H
S
L
V
Q
S
Y
G
--------------------------------------------------
N
D
Y
E
---
A
F
M
A
Y
A
K
T
H
R
D
---
C
V
F
L
V
D
T
-----
Y
-----
D
T
L
K
A
G
V
P
S
A
I
R
V
A
R
E
---
M
GD
K
I
-
N
-
F
L
G
V
R
I
D
S
G
D
M
A
Y
I
S
K
R
V
R
E
Q
L
D
-
E
-
A
G
----
F
T
-------
E
A
K
-
I
-
Y
A
S
N
-----
D
L
D
E
N
T
I
L
N
L
K
M
Q
---
K
S
K
I
D
-
V
W
G
V
G
T
K
L
I
T
A
--------
Y
-
D
---------
Q
---------
P
----
A
L
G
A
V
F
K
L
V
S
I
------
E
G
EDG
Q
M
K
-----------
D
------
T
I
K
L
S
S
N
A
E
K
V
T
T
P
G
K
K
Q
V
W
R
I
T
R
-------------------------------------------------------------------------------------------------------------------------
23
HHSearch
47.81
19%
-26
- C4 -
-
4YUB
-
PNCB_HUMAN
B:
[16-428]
-----------
L
L
T
D
L
Y
Q
A
T
M
A
L
G
Y
W
R
-
A
-
G
R
A
R
D
A
A
E
F
E
L
F
F
R
R
C
P
F
G
--
G
A
F
A
L
-
A
A
G
L
R
D
C
V
R
F
L
R
A
F
R
L
R
D
A
D
V
Q
F
L
-
A
------
S
VL----
P
P
D
T
D
P
A
F
F
E
H
L
R
A
L
D
-
C
S
----
E
VTVRAL
P
-----
E
G
S
L
---
A
--
F
P
G
-
V
-----
P
L
----------
L
Q
V
S
G
P
L
L
V
V
Q
L
L
E
T
P
L
L
C
L
V
S
-------------
Y
A
-------------------
S
-
L
V
A
T
N
A
---
A
R
L
R
L
I
A
-----
G
--
P
E
K
R
L
L
E
M
G
L
R
R
A
Q
G
P
D
G
G
---
L
T
A
S
T
Y
S
Y
-------
L
G
G
F
D
S
---
S
S
N
V
L
A
G
Q
L
R
G
V
P
V
A
G
T
L
A
H
S
F
V
T
S
F
S
G
S
-
E
V
---
P
PDPMLAPAAGEGPGVDLAAKAQVWLEQVCAHLGLGVQE
P
H
P
G
E
R
A
---
A
F
V
A
Y
A
L
A
F
P
R
-
A
-
F
Q
G
L
L
D
T
-----
Y
-----
S
V
W
R
S
G
L
P
N
F
L
A
V
ALALGE
L
--
G
Y
-
R
-
A
V
G
V
R
L
D
S
G
D
L
L
Q
Q
A
Q
E
I
R
K
V
F
R
-
A
-
A
A
AQFQ
V
P
----
W
L
E
S
V
L
-
I
-
V
V
S
N
-----
N
I
D
E
E
A
L
A
R
L
A
Q
E
---
G
S
E
V
N
-
V
I
G
I
------------------------------------------
S
L
G
G
V
Y
K
L
V
A
V
------
G
G
-----
Q
-----------
P
------
R
M
K
-------
Q
T
L
P
G
S
K
A
A
F
R
L
L
G
-------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
47.71
26%
-2
- C4 -
-
4MZY
13
?
A:
[12-362]
-----------
L
H
T
D
M
Y
Q
I
N
M
M
Q
T
Y
W
E
L
G
-
R
A
-
D
L
H
A
V
--
F
E
C
Y
F
R
E
M
P
F
N
H
G
Y
A
I
-
F
A
G
L
E
R
L
V
N
Y
L
E
N
L
T
F
T
E
S
D
I
A
Y
L
-
R
------
E
------
V
E
E
Y
P
E
D
F
L
T
Y
L
A
N
F
E
-
F
K
C
T
V
-
R
------
S
-----
A
L
E
G
---
D
L
V
F
N
N
-
E
-----
P
L
----------
I
Q
I
E
G
P
L
A
Q
C
Q
L
V
E
T
A
L
L
N
M
V
N
------------
F
Q
T
L
I
A
T
K
-------
A
A
-------
R
I
K
S
V
I
---------------
G
D
-
D
P
L
L
--
E
F
G
T
R
R
A
Q
E
L
D
------
A
A
I
W
G
T
R
-------
A
A
Y
I
G
G
ADA
T
S
N
V
R
A
G
K
I
F
G
I
P
V
S
G
T
H
A
H
S
L
V
Q
S
Y
G
------------------------------------------------
N
D
Y
E
-----
A
F
M
A
Y
A
K
T
H
R
D
---
C
V
F
L
V
D
T
YDTLK
A
-----
G
V
P
S
-
A
I
R
V
A
R
E
M
------
G
--
D
K
-
I
N
F
L
G
V
R
I
D
S
------
G
D
M
A
Y
I
S
K
R
V
R
-
E
Q
----
L
D
E
A
GF
T
-
E
A
K
I
-
Y
-
A
S
N
D
LD
E
N
T
I
L
N
L
-------
K
M
Q
K
-
S
K
I
D
V
--
W
G
V
G
T
K
L
I
T
A
--------
Y
-
D
---------
Q
---------
P
----
A
L
G
A
V
F
K
L
V
S
I
------
E
G
-----
E
DG
Q
M
K
D
T
I
K
L
S
S
------
N
A
E
K
V
T
T
P
G
K
---------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
47.49
19%
-21
- C4 -
-
4YUB
-
PNCB_HUMAN
A:
[16-428]
-----------
L
L
T
D
L
Y
Q
A
T
M
A
L
G
Y
W
R
-
A
-
G
R
A
R
D
A
A
E
F
E
L
F
F
R
R
C
P
F
G
--
G
A
F
A
L
-
A
A
G
L
R
D
C
V
R
F
L
R
A
F
R
L
R
D
A
D
V
Q
F
L
-
A
------
S
VL----
P
P
D
T
D
P
A
F
F
E
H
L
R
A
L
D
-
C
S
----
E
V
T
V
R
A
L
P
-----
E
G
S
L
---
A
--
F
P
G
-
V
-----
P
L
----------
L
Q
V
S
G
P
L
L
V
V
Q
L
L
E
T
P
L
L
C
L
V
S
-------------
Y
A
-------------------
S
-
L
V
A
T
N
A
---
A
R
L
R
L
I
A
-----
G
--
P
E
K
R
L
L
E
M
G
L
R
R
A
Q
G
P
D
G
G
---
L
T
A
S
T
Y
S
Y
-------
L
G
G
F
D
S
---
S
S
N
V
L
A
G
Q
L
R
G
V
P
V
A
G
T
L
A
H
S
F
V
T
S
F
S
G
S
-
E
V
---
P
PDPMLAPAAGEGPGVD
L
A
A
K
A
Q
V
W
L
E
Q
V
C
A
H
L
GLGVQE
P
H
P
G
E
R
A
---
A
F
V
A
Y
A
L
A
F
P
R
-
A
-
F
Q
G
L
L
D
T
-----
Y
-----
S
V
W
R
S
G
L
P
N
F
L
A
V
A
L
A
L
G
E
L
--
G
Y
-
R
-
A
V
G
V
R
L
D
S
G
D
L
L
Q
Q
A
Q
E
I
R
K
V
F
R
-
A
-
A
A
A
Q
F
Q
V
P
----
W
L
E
S
V
L
-
I
-
V
V
S
N
-----
N
I
D
E
E
A
L
A
R
L
A
Q
E
---
G
S
E
V
N
-
V
I
G
I
------------------------------------------
S
L
G
G
V
Y
K
L
V
A
V
------
G
G
-----
Q
-----------
P
------
R
M
K
L
T
-------
L
P
G
S
K
A
A
F
R
L
L
G
-------------------------------------------------------------------------------------------------------------------------