@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPS9: (2017-11-23 )
MKQDTVIQKIWSLCNILRGDGITYYQYVSELSYLLFLKIAQENGSEILIPEGYRWADLEAHEEEGLLGFYQEMLTHLGANVENEVIRDIYAFPTTVFSHSENLKAVIDGISEIEWHQVGKDGFGDLYSGLIDKSAQDTRSGAGQYFTPRSLINSIIRLIQPNLGDLIQDPATGSGGFLVSADSYIRTKSSQEEYQASPPKYQGVEIEKNTRRICLMNTFLHHLDANIVYGDALTDDVLKLDDPDIILANPPFGNKAGSQRPLRSDLPFPNTNKQLAFLQHIYLSLKAGGRAAVVLPDNVLFESGIGTDVRKDLMNKCNLHTILRLPTGIFYAQGVKTNVLFFTKGSTKDKHQQENCTENVWIYDLRTNMPSFGKRTPFGNADIGFLPEDFGTDSHLGAFERVFGDNPNGTSKRTEGEYSFNALEAEVDKELENENIDEKLAHSRWRCFSREWIAEYKGDSLDISWLKDKESIDADNLTEPAILVNEAKEELEAALAELESLLAALEGSN
Atome Classification :
(20 SA)
------.........10........--20.-..-......30......--------.-.40....-------------.--------------------------------------------------.------------------------------------------..50--------------.........60---...----......70------------..-------------.....------..80-------------..--..-....90....--------....100-------.......110----.------.-------------------.----.----.-..120.......130......-.140.......150.......---------------160-------------------........--------.170.......180...----.----------------.--.-------.190---------------.----.......200---.------.......210....-...220.--..---------------------.---.------.-------------------...230------..---...---.---.240.---.---.----....250...----....260---...-.-----------.---.----.-----------.270...----...-.280....-------.-------..290.......300...-...-..310..-....-----.320.......330------.-.......340......------------.350.......360.--...-----------..-.370.-......---..380.......390---........400.......410.......420----------........430.......440.......450...----..---------..460.......470---------........480........490.--------...--...500.......-----------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------MK
Q
D
T
V
I
Q
K
I
W
S
L
C
N
I
L
RG--D-G-
I
T
-
Y
Y
Q
Y
V
S
E
L
S
Y
L
L
F
L
--------
K
-
I
AQENG
S
-------------
E
--------------------------------------------------
I
------------------------------------------LIP---------------EGYRWADLEA----HEE----E
G
L
L
G
F
Y
-------------
Q
E
-------------
M
L
T
HL------GAN
V
-------------
E
N
--
E
V
-
I
R
D
I
Y
AFP
T
T
--------
V
FSHSE
N
-------
L
K
A
V
I
D
G
I
S
E
----
I
------
E
-------------------
W
----
H
----Q-VGKDG
F
G
D
L
Y
S
G
L
I
DKSAQDT-RSGAGQYF
T
P
R
S
L
I
N
S
I
I
R
LI---------------Q---------------------P
N
L
G
D
L
IQ--------DPATGSG
G
F
L
VSAD
S
Y
I
----R----------------T--K-------SS
Q
----------------
E
----
E
YQASPPKY----Q------
G
V
E
I
EKNT
R
R
I
C
L
M
-
N
T
F
L
--
H
--HL---------------------D---A------
N
-------------------
I
V
YGDA------LT---D
D
V
---L---KLDDP---
D
---
I
----
I
L
ANPPFGNK----AGSQRP----LRS-D-----------L---P----F-----------PNTN
K
Q
L
----
A
F
L
-
Q
H
I
Y
L
SLK-------A-------G
G
R
A
A
V
V
LPDN
V
L
F-ESG-IG
T
-
D
V
R
K
D
L
M
-
N
KCN-----
L
H
T
I
L
RLPTG
I
F
Y
-------A-QGVK
T
N
V
L
F
F
TKGSTK------------D
K
H
Q
Q
ENCTE
N
V
W
I
Y
--
D
LR-----------TN-MP--S-FGKRTP---FGNADIGFLPEDFG----TDS
H
L
G
A
F
E
R
V
FGDNPNGTSKRTEGEYSFN-----------
A
L
E
A
E
V
D
K
E
LENEN
I
D
E
K
L
A
H
S
R
W
R
C
F
S
R
E
W
I
A
E
----YK---------GDSL
D
I
S
WLKDKES----------IDADNLTE
P
A
-
I
L
V
N
E
A
K
E
E
L
E
A
--------
A
L
A
--
E
L
E
S
L
L
A
A
LEGSN-----------------------------------------------------------------------------------------------------
32
HHSearch
71.87
51%
28
- C3 -
-
2Y7H
2
T1MK_ECOLI
C:
[1-509]
------
M
N
N
N
D
L
V
A
K
L
W
K
L
C
D
N
L
R
D
--
G
-
G
-
V
S
-
Y
Q
N
Y
V
N
E
L
A
S
L
L
F
L
--------
K
-
M
C
K
E
T
G
Q
-------------
E
A-------------------------------------------------
E
------------------------------------------
Y
L
P
---------------
E
G
Y
R
W
D
D
L
K
S
----
R
I
G
----
Q
E
Q
L
Q
F
Y
-------------
R
K
-------------
M
L
V
H
L
------
G
E
D
D
--------------
K
--
K
L
-
V
Q
A
V
F
H
N
V
S
T
--------
T
I
T
E
P
K
Q
-------
I
T
A
L
V
S
N
M
D
S
----
L
------
D
-------------------
W
----
Y
NGAH
G
-
K
S
R
D
D
F
G
D
M
Y
E
G
L
L
Q
K
N
A
N
E
T
-
K
S
G
A
G
Q
Y
F
T
P
R
P
L
I
K
T
I
I
H
L
L
---------------
K
---------------------
P
Q
P
R
E
V
V
Q
--------
D
P
A
A
G
T
A
G
F
L
I
E
A
D
R
Y
V
----
K
----------------
S
--
Q
-------
T
N
D
LDDLDGD---------
T
----
Q
D
F
Q
I
H
R
A
F
----
I
------
G
L
E
L
V
P
G
T
R
R
L
A
L
M
-
N
C
L
L
--
H
--
D
I
---------------------
E
---
G
NLDHGG
A
-------------------
I
R
L
G
N
T
------
L
G
---
S
D
G
---
E
---
N
L
P
K
A
---
H
---
I
----
V
A
T
N
P
P
F
G
S
A
----
A
G
T
N
I
------
T
R
-
T
-----------
F
---
V
----
H
-----------
P
T
S
N
K
Q
L
----
C
F
M
-
Q
H
I
I
E
T
L
H
-------
P
-------
G
G
R
A
A
V
V
V
P
D
N
V
L
F
-
E
G
G
-
K
G
T
-
D
I
R
R
D
L
M
-
D
K
C
H
-----
L
H
T
I
L
R
L
P
T
G
I
F
Y
-------
A
-
Q
G
V
K
T
N
V
L
F
F
T
K
G
T
V
A
------------
N
P
N
Q
D
K
N
C
T
D
D
V
W
V
Y
--
D
L
R
-----------
T
N
-
M
P
--
S
-
F
G
K
R
T
P
---
F
T
D
E
-----------------
H
L
Q
P
F
E
R
V
Y
G
E
D
P
H
G
L
S
P
R
T
E
G
E
W
S
F
N
-----------
A
E
E
T
E
V
A
D
S
E
E
N
K
N
T
D
Q
H
L
A
T
S
R
W
R
K
F
S
R
E
W
I
R
T
----
A
K
---------
S
D
S
L
D
I
S
W
L
K
D
K
D
S
----------
I
D
A
D
S
L
P
E
P
D
-
V
L
A
A
E
A
M
G
E
L
V
Q
--------
A
L
S
--
E
L
D
A
L
M
R
E
L
G
A
-------------------------------------------------------------------------------------------------------
20
PsiBlast_CBE
69.86
48%
32
- C3 -
-
2Y7H
2
T1MK_ECOLI
C:
[1-511]
------
M
N
N
N
D
L
V
A
K
L
W
K
L
C
D
N
L
R
D
--
G
-
G
-
V
S
-
Y
Q
N
Y
V
N
E
L
A
S
L
L
F
L
--------
K
-
M
C
K
E
T
G
Q
-------------
E
--------------------------------------------------
A
E-----------------------------------------
Y
L
P
---------------
E
G
Y
R
W
D
D
L
K
S
----
R
I
G
----
Q
E
Q
L
Q
F
Y
-------------
R
K
-------------
M
L
V
H
L
------
G
E
D
--------------
D
K
--
K
L
-
V
Q
A
V
F
H
N
V
S
T
--------
T
I
T
E
P
K
Q
-------
I
T
A
L
V
S
N
M
D
S
----
L
------
D
-------------------
W
YNGA
H
----
G
-
K
S
R
D
D
F
G
D
M
Y
E
G
L
L
Q
K
N
A
N
E
T
-
K
S
G
A
G
Q
Y
F
T
P
R
P
L
I
K
T
I
I
H
L
L
---------------
K
---------------------
P
Q
P
R
E
V
V
Q
--------
D
P
A
A
G
T
A
G
F
L
I
E
A
D
R
Y
V
----
K
----------------
S
--
Q
-------
T
N
D
L---------------
D
----
D
L
D
G
D
T
Q
D
F
----
Q
IHRAFI
G
L
E
L
V
P
G
T
R
R
L
A
L
M
-
N
C
L
L
--
H
--
D
I
---------------------
E
---
G
------
N
-------------------
L
D
H
G
G
A
IRLGNT
L
G
---
S
D
G
---
E
---
N
L
P
K
A
---
H
---
I
----
V
A
T
N
P
P
F
G
S
A
----
A
G
T
N
------
I
T
R
-
T
-----------
F
---
V
----
H
-----------
P
T
S
N
K
Q
L
----
C
F
M
-
Q
H
I
I
E
T
L
H
-------
P
-------
G
G
R
A
A
V
V
V
P
D
N
V
L
F
-
E
G
G
-
K
G
T
-
D
I
R
R
D
L
M
-
D
K
C
H
-----
L
H
T
I
L
R
L
P
T
G
I
F
Y
-------
A
-
Q
G
V
K
T
N
V
L
F
F
T
K
G
T
V
A
------------
N
P
N
Q
D
K
N
C
T
D
D
V
W
V
Y
--
D
L
R
-----------
T
N
-
M
P
--
S
-
F
G
K
R
T
P
---
F
-----------------
T
D
E
H
L
Q
P
F
E
R
V
Y
G
E
D
P
H
G
L
S
P
R
T
E
G
E
W
S
F
N
-----------
A
E
E
T
E
V
A
D
S
E
E
N
K
N
T
D
Q
H
L
A
T
S
R
W
R
K
F
S
R
E
W
I
R
T
----
A
K
---------
S
D
S
L
D
I
S
W
L
K
D
K
D
S
----------
I
D
A
D
S
L
P
E
P
D
-
V
L
A
A
E
A
M
G
E
L
V
Q
--------
A
L
S
--
E
L
D
A
L
M
R
E
L
G
A
S
D
-----------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
69.55
48%
32
- C3 -
-
2Y7C
-
T1MK_ECOLI
B:
[1-511]
------
M
N
N
N
D
L
V
A
K
L
W
K
L
C
D
N
L
R
D
--
G
-
G
-
V
S
-
Y
Q
N
Y
V
N
E
L
A
S
L
L
F
L
--------
K
-
M
C
K
E
T
G
Q
-------------
E
--------------------------------------------------
A
E-----------------------------------------
Y
L
P
---------------
E
G
Y
R
W
D
D
L
K
S
----
R
I
G
----
Q
E
Q
L
Q
F
Y
-------------
R
K
-------------
M
L
V
H
L
------
G
E
D
--------------
D
K
--
K
L
-
V
Q
A
V
F
H
N
V
S
T
--------
T
I
T
E
P
K
Q
-------
I
T
A
L
V
S
N
M
D
S
----
L
------
D
-------------------
W
YNGA
H
----
G
-
K
S
R
D
D
F
G
D
M
Y
E
G
L
L
Q
K
N
A
N
E
T
-
K
S
G
A
G
Q
Y
F
T
P
R
P
L
I
K
T
I
I
H
L
L
---------------
K
---------------------
P
Q
P
R
E
V
V
Q
--------
D
P
A
A
G
T
A
G
F
L
I
E
A
D
R
Y
V
----
K
----------------
S
--
Q
-------
T
N
D
L---------------
D
----
D
L
D
G
D
T
Q
D
F
----
Q
I
HRA
F
I
G
L
E
L
V
P
G
T
R
R
L
A
L
M
-
N
C
L
L
--
H
--
D
I
---------------------
E
---
G
------
N
-------------------
L
D
H
G
G
A
I
R
L
G
N
T
L
G
---
S
D
G
---
E
---
N
L
P
K
A
---
H
---
I
----
V
A
T
N
P
P
F
G
S
A
----
A
G
T
N
------
I
T
R
-
T
-----------
F
---
V
----
H
-----------
P
T
S
N
K
Q
L
----
C
F
M
-
Q
H
I
I
E
T
L
H
-------
P
-------
G
G
R
A
A
V
V
V
P
D
N
V
L
F
-
E
G
G
-
K
G
T
-
D
I
R
R
D
L
M
-
D
K
C
H
-----
L
H
T
I
L
R
L
P
T
G
I
F
Y
-------
A
-
Q
G
V
K
T
N
V
L
F
F
T
K
G
T
V
A
------------
N
P
N
Q
D
K
N
C
T
D
D
V
W
V
Y
--
D
L
R
-----------
T
N
-
M
P
--
S
-
F
G
K
R
T
P
---
F
-----------------
T
D
E
H
L
Q
P
F
E
R
V
Y
G
E
D
P
H
G
L
S
P
R
T
E
G
E
W
S
F
N
-----------
A
E
E
T
E
V
A
D
S
E
E
N
K
N
T
D
Q
H
L
A
T
S
R
W
R
K
F
S
R
E
W
I
R
T
----
A
K
---------
S
D
S
L
D
I
S
W
L
K
D
K
D
S
----------
I
D
A
D
S
L
P
E
P
D
-
V
L
A
A
E
A
M
G
E
L
V
Q
--------
A
L
S
--
E
L
D
A
L
M
R
E
L
G
A
S
D
-----------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
69.35
48%
32
- C3 -
-
2Y7H
1
T1MK_ECOLI
B:
[1-511]
------
M
N
N
N
D
L
V
A
K
L
W
K
L
C
D
N
L
R
D
--
G
-
G
-
V
S
-
Y
Q
N
Y
V
N
E
L
A
S
L
L
F
L
--------
K
-
M
C
K
E
T
G
Q
-------------
E
--------------------------------------------------
A
E
-----------------------------------------
Y
L
P
---------------
E
G
Y
R
W
D
D
L
K
S
----
R
I
G
----
Q
E
Q
L
Q
F
Y
-------------
R
K
-------------
M
L
V
H
L
------
G
E
D
--------------
D
K
--
K
L
-
V
Q
A
V
F
H
N
V
S
T
--------
T
I
T
E
P
K
Q
-------
I
T
A
L
V
S
N
M
D
S
----
L
------
D
-------------------
W
YNGA
H
----
G
-
K
S
R
D
D
F
G
D
M
Y
E
G
L
L
Q
K
N
A
N
E
T
-
K
S
G
A
G
Q
Y
F
T
P
R
P
L
I
K
T
I
I
H
L
L
---------------
K
---------------------
P
Q
P
R
E
V
V
Q
--------
D
P
A
A
G
T
A
G
F
L
I
E
A
D
R
Y
V
----
K
----------------
S
--
Q
-------
T
N
D
L---------------
D
----
D
L
D
G
D
T
Q
D
F
----
Q
I
HRA
F
I
G
L
E
L
V
P
G
T
R
R
L
A
L
M
-
N
C
L
L
--
H
--
D
I
---------------------
E
---
G
------
N
-------------------
L
D
H
G
G
A
I
R
L
G
N
T
L
G
---
S
D
G
---
E
---
N
L
P
K
A
---
H
---
I
----
V
A
T
N
P
P
F
G
S
A
----
A
G
T
N
------
I
T
R
-
T
-----------
F
---
V
----
H
-----------
P
T
S
N
K
Q
L
----
C
F
M
-
Q
H
I
I
E
T
L
H
-------
P
-------
G
G
R
A
A
V
V
V
P
D
N
V
L
F
-
E
G
G
-
K
G
T
-
D
I
R
R
D
L
M
-
D
K
C
H
-----
L
H
T
I
L
R
L
P
T
G
I
F
Y
-------
A
-
Q
G
V
K
T
N
V
L
F
F
T
K
G
T
V
A
------------
N
P
N
Q
D
K
N
C
T
D
D
V
W
V
Y
--
D
L
R
-----------
T
N
-
M
P
--
S
-
F
G
K
R
T
P
---
F
-----------------
T
D
E
H
L
Q
P
F
E
R
V
Y
G
E
D
P
H
G
L
S
P
R
T
E
G
E
W
S
F
N
-----------
A
E
E
T
E
V
A
D
S
E
E
N
K
N
T
D
Q
H
L
A
T
S
R
W
R
K
F
S
R
E
W
I
R
T
----
A
K
---------
S
D
S
L
D
I
S
W
L
K
D
K
D
S
----------
I
D
A
D
S
L
P
E
P
D
-
V
L
A
A
E
A
M
G
E
L
V
Q
--------
A
L
S
--
E
L
D
A
L
M
R
E
L
G
A
S
D
-----------------------------------------------------------------------------------------------------
31
HHSearch
64.77
51%
42
- C3 -
-
2AR0
-
T1MK_ECOLI
B:
[6-511]
---------
N
D
L
V
A
K
L
W
K
L
C
D
N
L
R
D
--
G
-
G
-
V
S
-
Y
Q
N
Y
V
N
E
L
A
S
L
L
F
L
--------
K
-
M
C
K
E
T
G
Q
-------------
E
A-------------------------------------------------
E
------------------------------------------
Y
L
P
---------------
E
G
Y
R
W
D
D
L
K
S
----
R
I
G
----
Q
E
Q
L
Q
F
Y
-------------
R
K
-------------
M
L
V
H
L
------
G
E
D
D
--------------
K
--
K
L
-
V
Q
A
V
F
H
N
V
S
T
--------
T
I
T
E
P
K
Q
-------
I
T
A
L
V
S
N
M
D
S
----
L
------
D
-------------------
W
--------------------------------------
Q
Y
F
T
P
R
P
L
I
K
T
I
I
H
L
L
---------------
K
---------------------
P
Q
P
R
E
V
V
Q
--------
D
P
A
A
G
T
A
G
F
L
I
E
A
D
R
Y
V
----
K
----------------
S
--
Q
-------
T
N
D
LDDLDGD---------
T
----
Q
D
F
Q
I
H
R
A
F
----
I
------
G
L
E
L
V
P
G
T
R
R
L
A
L
M
-
N
C
L
L
--
H
--
D
I
---------------------
E
---
G
NLDHGG
A
-------------------
I
R
L
G
N
T
------
L
G
---
S
D
G
---
E
---
N
L
P
K
A
---
H
---
I
----
V
A
T
N
P
P
F
G
S
A
----
A
G
T
N
I
------
T
R
-
T
-----------
F
---
V
----
H
-----------
P
T
S
N
K
Q
L
----
C
F
M
-
Q
H
I
I
E
T
L
H
-------
P
-------
G
G
R
A
A
V
V
V
P
D
N
V
L
F
-
E
G
G
-
K
G
T
-
D
I
R
R
D
L
M
-
D
K
C
H
-----
L
H
T
I
L
R
L
P
T
G
I
F
Y
-------
A
-
Q
G
V
K
T
N
V
L
F
F
T
K
G
T
V
A
------------
N
P
N
Q
D
K
N
C
T
D
D
V
W
V
Y
--
D
L
R
-----------
T
N
-
M
P
--
S
-
F
G
K
R
T
P
---
F
T
D
E
-----------------
H
L
Q
P
F
E
R
V
Y
G
E
D
P
H
G
L
S
P
R
T
E
G
E
W
S
F
N
-----------
A
E
E
T
E
V
A
D
S
E
E
N
K
N
T
D
Q
H
L
A
T
S
R
W
R
K
F
S
R
E
W
I
R
T
----
A
K
---------
S
D
S
L
D
I
S
W
L
K
D
K
D
-----------------
P
E
P
D
-
V
L
A
A
E
A
M
G
E
L
V
Q
--------
A
L
S
--
E
L
D
A
L
M
R
E
L
G
A
-------------------------------------------------------------------------------------------------------
35
HHSearch
63.27
40%
-7
- C3 -
-
2OKC
1
T1M_BACTN
B:
[8-433]
-------
T
E
Q
S
L
T
K
K
V
W
N
L
A
T
T
L
A
G
--
Q
-
G
-
I
G
-
F
T
D
Y
I
T
Q
L
T
Y
L
L
F
L
--------
K
-
M
D
A
E
N
V
E
M
FGE---------
E
--------------------------------------------------
S
------------------------------------------
A
I
P
---------------
T
G
Y
Q
W
A
D
L
I
A
----
F
D
G
----
L
D
L
V
K
Q
Y
-------------
E
E
-------------
T
L
K
L
L
------
S
E
L
---------------
D
--
N
L
-
I
G
T
I
Y
T
K
A
Q
N
--------
K
I
D
K
P
V
Y
-------
L
K
K
V
I
T
M
I
D
E
----
E
------
Q
-------------------
W
----
L
----
I
-
M
D
G
D
V
K
G
A
I
Y
E
S
I
L
E
K
N
G
Q
D
K
-
K
S
G
A
G
Q
Y
F
T
P
R
P
L
I
Q
A
M
V
D
C
I
---------------
N
---------------------
P
Q
M
G
E
T
V
C
--------
D
P
A
C
G
T
G
G
F
L
L
T
A
Y
D
Y
M
----
K
----------------
G
--
Q
-------
S
A
S
K
E
--------------
K
----
R
D
F
L
R
D
K
A
L
----
H
------
G
V
D
N
T
P
L
V
V
T
L
A
S
M
-
N
L
Y
L
--
H
--
G
I
---------------------
G
TDR
S
------
P
-------------------
I
V
C
E
D
S
------
L
E
---
K
E
P
--------
S
T
L
V
---
D
---
V
----
I
L
A
N
P
P
F
G
T
R
----
P
A
G
S
V
D
I
---
N
R
P
-
D
-----------
F
---
Y
----
V
-----------
E
T
K
N
N
Q
L
----
N
F
L
-
Q
H
M
M
L
M
L
K
-------
T
-------
G
G
R
A
A
V
V
L
P
D
N
V
L
F
-
E
A
G
-
A
G
E
-
T
I
R
K
R
L
L
-
Q
D
F
N
-----
L
H
T
I
L
R
L
P
T
G
I
F
Y
-------
A
-
Q
G
V
K
A
N
V
L
F
F
S
K
G
Q
P
---------------------
T
K
E
I
W
F
Y
--
D
Y
R
-----------
T
D
-
I
K
--
H
-
T
L
A
T
N
K
---
L
E
R
H
-----------------
H
L
D
D
F
V
S
C
Y
N
N
R
V
E
I
------------------------------------
Y
D
A
E
N
N
P
Q
G
R
W
R
K
Y
P
V
D
E
I
I
A
----
R
D
---------
K
T
S
L
D
I
T
W
I
K
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
63.03
48%
43
- C3 -
-
2AR0
-
T1MK_ECOLI
A:
[6-513]
---------
N
D
L
V
A
K
L
W
K
L
C
D
N
L
R
D
--
G
-
G
-
V
S
-
Y
Q
N
Y
V
N
E
L
A
S
L
L
F
L
--------
K
-
M
C
K
E
T
G
Q
-------------
E
--------------------------------------------------
A
E-----------------------------------------
Y
L
P
---------------
E
G
Y
R
W
D
D
L
K
S
----
R
I
G
----
Q
E
Q
L
Q
F
Y
-------------
R
K
-------------
M
L
V
H
L
------
G
E
D
--------------
D
K
--
K
L
-
V
Q
A
V
F
H
N
V
S
T
--------
T
I
T
E
P
K
Q
-------
I
T
A
L
V
S
N
M
D
S
----
L
------
D
-------------------
W
--------------------------------------
Q
Y
F
T
P
R
P
L
I
K
T
I
I
H
L
L
---------------
K
---------------------
P
Q
P
R
E
V
V
Q
--------
D
P
A
A
G
T
A
G
F
L
I
E
A
D
R
Y
V
----
K
----------------
S
--
Q
-------
T
N
D
L---------------
D
----
D
L
D
G
D
T
Q
D
F
----
Q
I
HRA
F
I
G
L
E
L
V
P
G
T
R
R
L
A
L
M
-
N
C
L
L
--
H
--
D
I
---------------------
E
---
G
------
N
-------------------
L
D
H
G
G
A
I
R
L
G
N
T
L
G
---
S
D
G
---
E
---
N
L
P
K
A
---
H
---
I
----
V
A
T
N
P
P
F
G
S
A
----
A
G
T
N
------
I
T
R
-
T
-----------
F
---
V
----
H
-----------
P
T
S
N
K
Q
L
----
C
F
M
-
Q
H
I
I
E
T
L
H
-------
P
-------
G
G
R
A
A
V
V
V
P
D
N
V
L
F
-
E
G
G
-
K
G
T
-
D
I
R
R
D
L
M
-
D
K
C
H
-----
L
H
T
I
L
R
L
P
T
G
I
F
Y
-------
A
-
Q
G
V
K
T
N
V
L
F
F
T
K
G
T
V
A
------------
N
P
N
Q
D
K
N
C
T
D
D
V
W
V
Y
--
D
L
R
-----------
T
N
-
M
P
--
S
-
F
G
K
R
T
P
---
F
-----------------
T
D
E
H
L
Q
P
F
E
R
V
Y
G
E
D
P
H
G
L
S
P
R
T
E
G
E
W
S
F
N
-----------
A
E
E
T
E
V
A
D
S
E
E
N
K
N
T
D
Q
H
L
A
T
S
R
W
R
K
F
S
R
E
W
I
R
T
----
A
K
---------
S
D
S
L
D
I
S
W
L
K
D
K
D
-----------------
P
E
P
D
-
V
L
A
A
E
A
M
G
E
L
V
Q
--------
A
L
S
--
E
L
D
A
L
M
R
E
L
G
A
S
D
-----------------------------------------------------------------------------------------------------
21
Fugue
55.13
44%
39
- C3 -
-
2AR0
-
T1MK_ECOLI
A:
[6-529]
---------
N
D
L
V
A
K
L
W
K
L
C
D
N
L
R
D
--
G
-
G
-
V
S
-
Y
Q
N
Y
V
N
E
L
A
S
L
L
F
L
--------
K
M
C
K
E
T
G
Q
E
-------------
A
--------------------------------------------------
E
------------------------------------------
Y
L
P
---------------
E
G
Y
R
W
D
D
L
K
S
----
R
I
G
----
Q
E
Q
L
Q
F
Y
-------------
R
K
M
------------
L
V
H
L
G
------
E
D
D
--------------------------------------------------------------
K
----
K
------
L
-------------------
V
----
Q
----
A
-
V
F
H
N
V
S
T
T
I
T
E
P
K
Q
I
T
A
L
V
S
N
M
D
S
L
D
W
Q
Y
F
T
P
R
P
L
I
K
T
I
I
H
L
L
---------------
K
---------------------
P
Q
P
R
E
V
V
Q
--------
D
P
A
A
G
T
A
G
F
L
I
E
A
D
R
Y
V
----
K
----------------
S
--
Q
T
N
DLDDL
D
G
D
----------------
T
----
Q
D
F
Q
I
H
R
A
F
----
I
------
G
L
E
L
V
P
G
T
R
R
L
A
-
L
M
N
C
L
L
--
H
--
D
I
---------------------
E
---
G
NLDHGG
A
-------------------
I
R
L
G
N
T
------
L
G
---
S
D
G
---
E
---
N
L
P
K
A
---
H
---
I
----
V
A
T
N
P
P
F
G
S
A
----
A
G
T
N
I
T
--------
R
-----------
T
---
F
----
V
-----------
H
P
T
S
N
K
Q
----
L
C
F
M
Q
H
I
I
E
T
L
H
-------
P
-------
G
G
R
A
A
V
V
V
P
D
N
V
L
F
-
E
G
G
--
K
G
-
T
D
I
R
R
D
L
M
D
K
C
H
-----
L
H
T
I
L
R
L
P
T
G
I
F
Y
-------
A
-
Q
G
V
K
T
N
V
L
F
F
T
K
G
T
V
A
------------
N
P
N
Q
D
K
N
C
T
D
D
V
W
V
Y
--
D
L
R
-----------
T
N
M
P
S
--
F
--
G
K
R
T
P
---
F
-----------------
T
D
E
H
L
Q
P
F
E
R
V
Y
G
E
D
P
H
G
L
S
P
R
T
E
G
E
W
S
F
N
-----------
A
E
E
T
E
V
A
D
S
E
E
N
K
N
T
D
Q
H
L
A
T
S
R
W
R
K
F
S
R
E
W
I
R
T
----
A
K
---------
S
D
S
L
D
I
S
W
L
K
D
K
D
P
-----------
E
P
D
V
L
A
A
E
A
M
G
E
L
V
Q
A
L
S
E
L
D
A
L
M
R
E
LGAS
D
E
A
--
D
L
Q
R
Q
L
L
E
E
A
F
G
G
V----------------------------------------------------------------------------------------------------
33
HHSearch
50.25
23%
14
- C3 -
-
3LKD
-
?
A:
[6-476]
------
Q
T
S
Q
S
L
Y
Q
A
L
W
N
S
A
D
V
L
R
S
--
K
---
M
D
-
A
N
D
Y
K
S
Y
L
L
G
M
V
F
Y
--------
K
-
Y
L
S
D
K
M
L
-------------
F
--------------------------------------------------
F
V
A
E
T
M
EEETES
L
D
E
A
L
A
V
Y
R
K
Y
Y
E
DEET
H
E
D
L
L
A
V
I
T
D
E
MS
Y
A
I
H
---------------
P
D
L
T
F
T
A
L
V
E
----
R
V
N
D
G--
S
F
Q
L
E
D
L
-------------
A
Q
-------------
G
F
R
D
I
------
E
Q
S
---------------
D
--
E
L
-
Y
E
N
L
F
E
D
I
D
L
YSKKLGAT
P
Q
K
Q
N
Q
T
-------
V
A
A
V
M
K
E
L
A
V
----
L
------
D
-------------------
V
----
A
----
G
-
H
A
G
D
M
L
G
D
A
Y
E
Y
L
I
G
Q
F
A
T
D
----
K
A
G
E
F
Y
T
P
Q
P
V
A
K
L
M
T
Q
I
A
---------------
F
LGRE-----------------
D
K
Q
G
F
T
L
Y
--------
D
A
T
M
G
S
G
S
L
L
L
N
A
K
R
Y
S
----
R
----------------
Q
--
P
-----------------------------------
Q
T
V
V
Y
----
F
------
G
Q
E
L
N
T
S
T
Y
N
L
A
R
M
-
N
M
I
L
--
H
--
G
V
---------------------
P
---
I
EN
Q
---
F
-------------------
L
H
N
A
D
T
------
L
D
---
E
D
W
PT-
Q
---
E
P
T
N
F
---
D
---
G
----
V
L
M
N
P
P
Y
S
A
K
----
W
S
A
S
S
G
FMDD
P
R
F
S
P
-----------
F
---
G
KL--
A
-----------
P
K
S
K
A
D
F
----
A
F
L
-
L
H
G
Y
Y
H
L
K
Q------
D
-------
N
G
V
M
A
I
V
L
P
H
G
V
L
F
-
R
G
N
-
A
E
G
-
T
I
R
K
A
L
L
-
E
E
G
A
-----
I
D
T
V
I
G
L
P
A
N
I
F
F
-------
N
-
T
S
I
P
T
T
V
I
I
L
K
K
N
R
T
---------------------
N
R
D
V
Y
F
I
--
D
A
S
-----------
K
E
-
F
D
--
K
-
G
K
N
Q
N
I
---
M
T
D
A
-----------------
H
I
E
K
I
L
N
A
Y
K
S
R
E
D
-------------------------------------------
I
D
K
F
A
H
L
A
S
F
E
E
I
V
E
-----
N
---------
D
Y
N
L
N
I
P
R
Y
V
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
49.90
23%
14
- C3 -
-
3LKD
-
?
B:
[7-478]
-------
T
S
Q
S
L
Y
Q
A
L
W
N
S
A
D
V
L
R
S
--
K
---
M
D
-
A
N
D
Y
K
S
Y
L
L
G
M
V
F
Y
--------
K
-
Y
L
S
D
K
M
L
-------------
F
--------------------------------------------------
F
V
A
E
T
M
EEETES
L
D
E
A
L
A
V
Y
R
K
Y
Y
E
DEET
H
E
D
L
L
A
V
I
T
D
E
MSY
A
I
H
---------------
P
D
L
T
F
T
A
L
V
E
----
R
V
N
D
G--
S
F
Q
L
E
D
L
-------------
A
Q
-------------
G
F
R
D
I
------
E
Q
S
---------------
D
--
E
L
-
Y
E
N
L
F
E
D
I
D
L
YSKKLGAT
P
Q
K
Q
N
Q
T
-------
V
A
A
V
M
K
E
L
A
V
----
L
------
D
-------------------
V
----
A
----
G
-
H
A
G
D
M
L
G
D
A
Y
E
Y
L
I
G
Q
F
A
T
D
S
-
G
K
K
A
G
E
F
Y
T
P
Q
P
V
A
K
L
M
T
Q
I
A
---------------
F
LGRE-----------------
D
K
Q
G
F
T
L
Y
--------
D
A
T
M
G
S
G
S
L
L
L
N
A
K
R
Y
S
----
R
----------------
Q
--
P
-----------------------------------
Q
T
V
V
Y
----
F
------
G
Q
E
L
N
T
S
T
Y
N
L
A
R
M
-
N
M
I
L
--
H
--
G
V
---------------------
P
---
I
EN
Q
---
F
-------------------
L
H
N
A
D
T
------
L
D
---
E
D
W
PT-
Q
---
E
P
T
N
F
---
D
---
G
----
V
L
M
N
P
P
Y
S
A
K
----
W
S
A
S
S
G
F
M
D
D
P
R
F
S
P
-----------
F
---
G
KL--
A
-----------
P
K
S
K
A
D
F
----
A
F
L
-
L
H
G
Y
Y
H
L
K
Q------
D
-------
N
G
V
M
A
I
V
L
P
H
G
V
L
F
-
R
G
N
-
A
E
G
-
T
I
R
K
A
L
L
-
E
E
G
A
-----
I
D
T
V
I
G
L
P
A
N
I
F
F
-------
N
-
T
S
I
P
T
T
V
I
I
L
K
K
N
R
T
---------------------
N
R
D
V
Y
F
I
--
D
A
S
-----------
K
E
-
F
D
--
K
-
G
K
N
Q
N
I
---
M
T
D
A
-----------------
H
I
E
K
I
L
N
A
Y
K
S
R
E
D
-------------------------------------------
I
D
K
F
A
H
L
A
S
F
E
E
I
V
E
-----
N
---------
D
Y
N
L
N
I
P
R
Y
V
D
T
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
49.62
25%
16
- C3 -
-
3UFB
-
?
A:
[18-495]
-------
T
A
Q
Q
L
G
A
I
V
K
S
S
R
Q
I
M
R
K
--
D
K
G
L
N
G
-
D
L
D
R
L
P
M
L
T
W
I
M
F
L
--------
K
-
F
L
D
D
L
E
Q
M
R
E
T
E
A
V
L
E
G
K
S
F
Q
--------------------------------------------------
P
------------------------------------------
A
I
E
---------------
A
P
Y
R
W
R
D
W
A
A
----
I
E
G
GITG
D
E
L
I
A
F
I
-------------
N
N
DEAMRPDGTRGIG
L
F
A
Y
L
------
R
S
L
Q
GDNGGD-------
R
R
--
D
V
-
I
A
T
V
F
K
G
M
Q
N
--------
R
M
I
N
G
Y
L
-------
L
R
D
V
V
D
K
I
N
G
----
I
------
H
-------------------
F
----
N
----
S
S
E
E
M
H
T
L
S
R
L
Y
E
T
M
L
R
E
M
R
D
-
A
-
A
G
D
S
G
E
F
Y
T
P
R
P
V
V
R
F
M
V
E
V
M
---------------
D
---------------------
P
Q
L
G
E
S
V
L
--------
D
P
A
C
G
T
G
G
F
L
V
E
A
F
E
H
L
----
E
----------------
R
--
Q
-------
C
K
T
V
E
--------------
D
----
R
E
V
L
Q
E
S
S
I
----
F
------
G
G
E
A
K
S
L
P
Y
L
L
V
Q
M
-
N
L
L
L
--
H
--
G
L
---------------------
E
---
Y
P-----
R
-------------------
I
D
P
E
N
S
------
L
R
---
F
P
L
---
R
EMG
D
K
D
R
V
---
D
---
V
----
I
L
T
N
P
P
F
G
G
E
----
E
E
K
G
I
------
L
G
-
N
-----------
F
---
P
ED--
M
-----------
Q
T
A
E
T
A
M
----
L
F
L
-
Q
L
I
M
R
K
L
K
RPGHGSD
N
-------
G
G
R
A
A
V
V
V
P
N
G
T
L
F
-
S
D
G
-
I
S
A
-
R
I
K
E
E
L
L
-
K
N
F
N
-----
L
H
T
I
V
R
L
P
E
G
V
F
A
-------
P
Y
T
D
I
A
G
N
L
L
F
F
D
R
S
G
P
---------------------
T
D
D
I
W
Y
Y
--
Q
I
T
-----------
V
P
-
E
G
RK
K
-
Y
T
K
T
K
P
---
M
E
S
H
-----------------
E
F
D
E
C
L
N
W
W
S
N
R
I
V
--------------------------------------------
N
Q
N
A
W
K
E
S
A
S
E
I
I
K
YSES
G
Q
---------
L
I
D
V
N
L
D
R
K
N
P
N
S
L
----------
E
V
-
L
E
H
------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
47.45
25%
24
- C3 -
-
3UFB
-
?
A:
[12-495]
-ADQPM
T
T
A
Q
Q
L
G
A
I
V
K
S
S
R
Q
I
M
R
K
--
D
K
G
-
L
N
G
D
L
D
R
L
P
M
L
T
W
I
M
F
L
--------
K
-
F
L
D
D
L
E
Q
-------------
M
--------------------------------------------------
R
E
T
E
A
V
L
E
G
K
S
F
Q
P
-----------------------------
A
I
E
---------------
A
P
Y
R
W
R
D
W
A
A
----
I
E
G
GITG
D
E
L
I
A
F
I
NNDEAMRPDGTRG
I
G
-------------
L
F
A
Y
L
R
S
LQGD
N
G
G
D
-------------
R
R
--
D
V
-
I
A
T
V
F
K
G
M
Q
N
--------
R
M
I
N
G
Y
L
-------
L
R
D
V
V
D
K
I
N
G
----
I
------
H
-------------------
F
----
N
S---
S
-
E
E
M
H
T
L
S
R
L
Y
E
T
M
L
-
R
E
M
R
D
A
-
A
G
D
S
G
E
F
Y
T
P
R
P
V
V
R
F
M
V
E
V
M
---------------
D
---------------------
P
Q
L
G
E
S
V
L
--------
D
P
A
C
G
T
G
G
F
L
V
E
A
F
E
H
L
----
E
----------------
R
Q
C
K
-------
T
V
E
----------------
D
----
R
E
V
L
Q
E
S
S
I
----
F
------
G
G
E
A
K
S
L
P
Y
L
L
V
Q
M
-
N
L
L
L
--
H
--
G
L
---------------------
E
---
Y
P-----
R
-------------------
I
D
P
E
N
S
------
L
R
---
F
P
L
---
R
---
E
M
G
D
K
DRV
D
---
V
----
I
L
T
N
P
P
F
G
G
E
----
E
E
K
G
I
L
----
G
N
F
-
P
-----------
E
---
D
----
M
-----------
Q
T
A
E
T
A
M
----
L
F
L
-
Q
L
I
M
R
K
L
K
-------
R
PGHGSDN
G
G
R
A
A
V
V
V
P
N
G
T
L
F
-
S
D
G
-
I
S
A
-
R
I
K
E
E
L
L
-
K
N
F
N
-----
L
H
T
I
V
R
L
P
E
G
V
F
A
-------
P
Y
T
D
I
A
G
N
L
L
F
F
D
R
S
G
P
---------------------
T
D
D
I
W
Y
Y
Q
I
T
V
P
-----------
E
G
-
R
K
--
K
-
Y
T
K
T
K
P
---
M
E
S
H
E
F
D
E
C
L
N
W
W
S
------------------------
N
R
I
V
N
Q
N
A
W
K
-----------
E
S
A
S
E
I
--------------------
I
K
Y
S
E
S
G
Q
----
L
I
---------
D
V
N
L
D
R
K
N
P
N
S
L
E
V
----------
L
E
H
---------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
44.46
20%
37
- C3 -
-
3KHK
-
?
A:
[10-530]
--------
L
N
D
L
D
N
Q
L
W
R
A
A
D
K
L
R
S
--
N
---
L
D
-
A
A
N
Y
K
H
V
V
L
G
L
I
F
L
--------
K
-
Y
V
S
D
A
F
E
-------------
E
R
Q
Q
E
L
T
E
L
F
Q
KDDDDNIYYLPREDYDS
D
E
A
Y
Q
Q
A
I
A
E
E
L
E
IG
D
Y
Y
T
E
K
NV
F
------------------------------------------
W
V
P
---------------
K
T
A
R
W
N
K
L
R
D
----
V
I
T
LPT--
S
V
S
W
L
I
-------------
D
N
-------------
A
F
D
D
I
------
E
K
A
---------------
N
--
P
K
-
L
K
G
I
L
N
R
I
S
Q
--------
Y
Q
L
D
A
D
K
-------
L
I
G
L
I
N
E
F
----------------------------------------------
S
K
D
I
L
G
H
V
Y
E
Y
F
L
G
Q
F
A
L
A
E
-
G
K
Q
G
G
Q
Y
Y
T
P
K
S
I
V
T
L
I
V
E
M
L
---------------
E
---------------------
P
Y
K
-
G
R
V
Y
--------
D
P
A
M
G
S
G
G
F
F
V
S
S
D
K
F
I
----
E
----------------
K
--
H
-------
A
N
V
----------------
K
HYN
A
S
E
Q
K
K
Q
I
S
V
----
Y
------
G
Q
E
S
N
P
T
T
W
K
L
A
A
M
-
N
M
V
I
--
R
--
G
I
---------------------
D
---
F
N
F----
G
-------------------
K
K
N
A
D
S
------
F
L
---
D
D
Q
---
H
---
P
D
L
R
A
---
D
---
F
----
V
M
T
N
P
P
F
N
M
K
----
D
W
W
H
E
K
LADD
P
R
W
-
T
I
N
T
N-------
K
RIL
T
----
P
-----------
P
T
G
N
A
N
F
----
A
W
M
-
L
H
M
L
Y
H
L
A
-------
P
-------
T
G
S
M
A
L
L
L
A
N
G
S
M
S
-
S
N
T
N
N
E
G
-
E
I
R
K
T
L
V
-
E
Q
D
L
-----
V
E
C
M
V
A
L
P
G
Q
L
F
T
-------
N
-
T
Q
I
P
A
C
I
W
F
L
T
K
D
K
N
A
------------
K
N
G
-
K
R
D
R
R
G
Q
V
L
F
I
--
D
A
R
-----------
K
L
-
G
Y
--
M
K
D
R
V
L
R
D
---
F
K
D
E
-----------------
D
I
Q
K
L
A
D
T
F
H
N
W
Q
Q
E
W
S
------------------------------------
E
E
N
N
Q
A
G
F
C
F
S
A
D
L
A
L
I
R
K
-----
N
---------
D
F
V
L
T
P
G
R
Y
V
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
41.55
21%
48
- C3 -
-
3KHK
-
?
A:
[7-530]
-----Q
Q
F
L
N
D
L
D
N
Q
L
W
R
A
A
D
K
L
R
S
NL
D
-
A
-
A
N
-
Y
K
H
V
V
L
G
L
I
F
L
K
Y
V
--------
S
-
D
A
F
E
E
R
Q
-------------
Q
--------------------------------------------------
E
------------------------------------------
L
T
E
L
F
Q
KDDDDNIYYLPR
E
D
Y
D
S
D
E
A
Y
Q
----
Q
A
I
----
A
E
E
L
E
I
G
-------------
D
Y
-------------
Y
T
E
K
N
------
V
F
W
V
-------------
P
K
--
T
A
R
W
N
K
L
R
D
V
I
T
L
--------
P
T
S
V
S
W
L
-------
I
D
N
A
F
D
D
I
E
K
A
N
PK
L
------
K
GILNRISQYQLD
A
D
K
L
I
G
L
I
----
N
----
E
-
F
S
K
D
I
L
G
H
V
Y
E
Y
F
L
G
Q
F
A
L
A
E
-
G
K
Q
G
G
Q
Y
Y
T
P
K
S
I
V
T
L
I
V
E
M
L
---------------
E
---------------------
P
Y
K
G
-
R
V
Y
--------
D
P
A
M
G
S
G
G
F
F
V
S
S
D
K
F
I
----
E
----------------
K
--
H
-------
A
N
V
----------------
K
----
H
Y
N
A
S
E
Q
K
K
Q
I
S
V
Y
------
G
Q
E
S
N
P
T
T
W
K
L
A
A
M
-
N
M
V
I
--
R
--
G
I
D
F
-------------------
N
---
F
------
G
-------------------
K
K
N
A
D
S
------
F
L
---
D
D
Q
---
H
---
P
D
L
R
A
---
D
---
F
----
V
M
T
N
P
P
F
N
M
K
----
D
W
W
H
E
K
----
L
A
D
-
D
-----------
P
---
R
----
W
T
I
N
T
NKRILTP
P
T
G
N
A
N
F
----
A
W
M
-
L
H
M
L
Y
H
L
A
-------
P
-------
T
G
S
M
A
L
L
L
A
N
G
S
M
S
S
N
T
N
-
N
E
G
-
E
I
R
K
T
L
V
-
E
Q
D
L
-----
V
E
C
M
V
A
L
P
G
Q
L
F
T
-------
N
-
T
Q
I
P
A
C
I
W
F
L
T
K
D
K
N
A
------------
K
N
G
K
R
D
R
R
G
Q
V
L
F
I
D
--
A
R
K
-----------
L
G
-
Y
M
--
K
-
D
R
V
L
R
D
---
F
K
D
E
D
I
Q
K
L
A
D
T
F
H
----
N
W
Q
Q
------------
E
W
S
E
E
N
N
Q
A
G
F
C
F
S
-----------
A
D
L
A
L
I
R
K
-------------------------------
N
---------
D
F
V
L
T
P
G
R
Y
V
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
40.23
28%
-4
- C3 -
-
3UFB
-
?
A:
[102-424]
----------------------------------------------------------
I
A
F
I
N
N
D
-------------
E
--------------------------------------------------
A
------------------------------------------
M
R
P
---------------
D
G
T
R
G
I
----------------
G
L
F
A
Y
L
-------------
R
S
-------------
L
Q
G
D
N
------
G
G
D
R
---------------------
R
D
V
I
A
---
T
--------
V
F
K
G
M
Q
N
RMIN
G
Y
L
L
R
D
V
V
D
K
I
N
G
----
I
HFNS
S
E
E
-------------------
M
----
H
----
T
-
L
S
R
-----
L
Y
E
T
M
L
-
R
E
M
R
D
A
-
A
G
D
S
G
E
F
Y
T
P
R
P
V
V
R
F
M
V
E
V
M
---------------
D
---------------------
P
Q
L
G
E
S
V
L
--------
D
P
A
C
G
T
G
G
F
L
V
E
A
F
E
H
L
E
R
Q
C
K
----------------
T
--
V
-------
E
D
R
----------------
E
----
V
L
Q
E
S
--
S
I
----
F
------
G
G
E
A
K
S
L
P
Y
L
L
V
Q
M
-
N
L
L
L
--
H
--
G
L
---------------------
E
Y--
P
------
R
-------------------
I
D
P
E
N
S
------
L
R
---
F
P
L
---
R
---
E
M
G
D
K
---
D
RVD
V
----
I
L
T
N
P
P
F
G
G
E
------
E
E
K
G
----
I
L
G
-
N
-----------
F
---
P
ED--
M
-----------
Q
T
A
E
T
A
M
----
L
F
L
-
Q
L
I
M
R
K
L
K
-------
R
PGHGSDN
G
G
R
A
A
V
V
V
P
N
G
T
L
F
-
S
D
G
-
I
S
A
-
R
I
K
E
E
L
L
-
K
N
F
N
-----
L
H
T
I
V
R
L
P
E
G
V
F
A
-------
P
Y
T
D
I
A
G
N
L
L
F
F
D
R
S
G
P
---------------------
T
D
D
I
W
Y
Y
--
Q
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
39.10
33%
-145
* C2 *
-
3VVI
-
?
A:
[1-21]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
K
L
R
A
--------
E
M
E
--
E
L
K
S
M
L
S
Q
L
G
K
T
------------------------------------------------------------------------------------------------------
38
HHSearch
37.70
18%
-11
- C3 -
-
5HR4
3
?
J:
[167-591]
-------------
E
R
M
G
K
L
H
D
T
L
K
L
--
V
-
G
-
Y
E
-
G
H
A
L
E
L
Y
L
V
R
L
L
F
C
--------
L
-
F
A
E
D
T
T
I
-------------
F
--------------------------------------------------
E
------------------------------------------
K
-------------------
S
L
F
Q
E
Y
I
E
TKTL
E
D
G
----
S
D
L
A
H
H
I
-------------
N
T
-------------
L
F
Y
V
L
------
N
T
P
E
QKRLKNLDEHLAA
F
P
--
Y
I
-
N
G
K
L
F
E
E
P
L
P
--------
P
A
Q
F
D
K
A
-------
M
R
E
A
L
L
D
L
C
S
----
L
------
D
-------------------
W
----
S
----
R
-
I
S
P
A
I
F
G
S
L
F
Q
S
I
M
D
A
K
---
K
-
R
R
N
L
G
A
H
Y
T
S
E
A
N
I
L
K
L
I
K
P
L
FL-------------
D
ELWVEFEKVKNNKNKLLAFHK
K
L
R
G
L
T
F
F
--------
D
P
A
C
G
C
G
N
F
L
V
I
T
Y
R
E
L
----
R
----------------
L
--
L
-------
E
I
E
VLRGLHRGGQQVLDIE
H
----
L
I
Q
I
N
V
D
Q
F
----
F
------
G
I
E
I
E
E
F
P
A
Q
I
A
Q
V
-
A
L
W
L
--
T
--
D
H
QMNMKISDEFGNYFARIPLKS
T
---
P
------
H
-------------------
I
L
N
A
N
A
------
L
Q
---
I
D
W
NDV
L
---
E
A
K
K
C
---
C
---
F
----
I
L
G
N
P
P
F
V
G
K
----
S
K
Q
T
P
G
QKAD
L
L
S
-
V
-----------
F
---
G
NLKS
A
-----------
S
D
L
D
L
V
A
----
A
W
Y
-
P
K
A
A
H
Y
I
Q
-------
T
NA-----
N
I
R
C
A
F
V
S
T
N
S
I
T
Q
-
G
-
E
-
Q
V
S
-
L
L
W
P
L
L
L
-
S
L
-
G
-----
I
K
--
I
N
F
A
H
R
T
F
S
WTNEASG
V
-
A
A
V
H
C
V
I
I
G
F
G
L
K
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
34.98
18%
21
- C3 -
-
5HR4
3
?
C:
[157-905]
PQDPIN
I
K
A
A
E
R
M
G
K
L
H
D
T
L
K
L
V
G
Y
--
E
-
G
-
H
A
-
L
E
L
Y
L
V
R
L
L
F
C
L
F
A
EDTTIFEK
S
-
L
F
Q
E
Y
I
E
-------------
T
--------------------------------------------------
K
------------------------------------------
T
L
E
---------------
D
G
---
S
D
L
A
H
----
H
I
N
----
T
L
F
Y
V
L
N
TPE----------
Q
K
-------------
R
L
K
N
L
------
D
E
H
L
-------------
A
A
FP
Y
I
-
N
G
K
L
F
E
E
P
L
P
--------
P
A
Q
F
D
K
A
-------
M
R
E
A
L
L
D
L
C
S
----
L
------
D
-------------------
W
----
S
----
R
-
I
S
P
A
I
F
G
S
L
F
Q
S
I
M
D
---
A
K
K
-
R
R
N
L
G
A
H
Y
T
S
E
A
N
I
L
K
L
I
K
P
L
FLDELWVEFEKVKNN
K
---------------------
N
K
L
L
A
F
H
K
KLRGLTFF
D
P
A
C
G
C
G
N
F
L
V
I
T
Y
R
E
L
----
R
LLEIEVLRGLHRGGQQ
V
--
L
-------
D
I
E
----------------
H
----
L
I
Q
I
N
V
D
Q
F
----
F
------
G
I
E
I
E
E
F
P
A
Q
I
A
Q
V
-
A
L
W
L
TD
H
--
Q
M
---------------------
N
---
M
------
K
ISDEFGNYFARIPLKSTPH
I
L
N
A
N
A
------
L
Q
IDW
N
D
V
---
L
---
E
A
K
K
C
---
C
---
F
----
I
L
G
N
P
P
F
V
G
K
SKQT
P
G
Q
K
A
D
----
L
L
S
-
V
-----------
F
---
G
----
N
-----------
L
K
S
A
S
D
L
DLVA
A
W
Y
-
P
K
A
A
H
Y
I
Q
-------
T
-------
N
A
N
I
R
C
A
F
V
S
T
N
S
I
-
T
Q
G
-
E
Q
V
-
S
L
L
W
P
L
L
-
L
S
L
G
IKINF
A
H
R
T
F
S
W
T
N
E
A
S
G
-------
V
-
A
A
V
H
C
V
I
I
G
F
G
L
K
D
S
D
------------
E
K
I
I
Y
E
Y
E
S
I
N
G
E
P
L
--
A
I
K
AKNINPYLRDG
V
D
-
V
I
--
A
-
C
K
R
Q
Q
P
ISK
L
P
S
M
R
Y
G
N
K
P
T
D
D
G
NFLF
T
D
E
E
K
N
Q
F
I
T
N
E
P
S
S
E
K
Y
F
R
R
F
V
G
G
D
E
F
I
N
NTSRWCLWLDG
A
D
I
S
E
I
R
A
M
P
L
V
L
A
R
I
K
K
V
Q
E
F
R
L
K
S
S
A
K
P
T
R
Q
S
----
A
S
TPMKFFYIS
Q
P
D
T
D
Y
L
L
I
P
E
T
S
S
ENRQFIPIGF
V
D
R
N
V
I
S
S
N
A
-
T
Y
H
I
P
S
A
E
P
L
I
F
--------
G
L
L
SS
T
M
H
N
C
W
M
R
N
V
G
G
R
LESRYRYSASLVYNTFPWIQPNEKQSKAIEEAAFAILKARSNYPNESLAGLYDPKTMPSELLKAHQKLDKAVDSVYGFKGPNTEIARIAFLFETYQKMTSL
6
PsiBlast_PDB
33.73
23%
40
- C3 -
-
3LKD
-
?
A:
[153-468]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
Q
T
-------
V
A
A
V
M
K
E
L
A
V
----
L
------
D
-------------------
V
----
A
----
G
-
H
A
G
D
M
L
G
D
A
Y
E
Y
L
I
G
Q
F
A
T
D
----
K
A
G
E
F
Y
T
P
Q
P
V
A
K
L
M
T
Q
I
A
F
LGR-----------
E
---------------------
D
K
Q
G
F
T
L
Y
--------
D
A
T
M
G
S
G
S
L
L
L
N
A
K
R
Y
S
----
R
-----------------------------------------------------
Q
P
Q
T
V
V
Y
----
F
------
G
Q
E
L
N
T
S
T
Y
N
L
A
R
M
-
N
M
I
L
--
H
GV
P
I
---------------------
E
---
N
------
Q
-------------------
F
L
H
N
A
D
------
T
L
---
D
E
D
---
W
---
P
T
Q
E
P
TNF
D
---
G
----
V
L
M
N
P
P
Y
S
A
K
----
W
S
A
S
S
G
----
F
M
D
-
D
-----------
P
---
R
----
F
SPFGKLA----
P
K
S
K
A
D
F
----
A
F
L
-
L
H
G
Y
Y
H
L
K
-------
Q
D------
N
G
V
M
A
I
V
L
P
H
G
V
L
F
-
R
G
N
-
A
E
G
-
T
I
R
K
A
L
L
-
E
E
G
A
-----
I
D
T
V
I
G
L
P
A
N
I
F
F
-------
N
-
T
S
I
P
T
T
V
I
I
L
K
K
N
R
T
N
R
D
V
Y
F
I
DASKEF
D
K
G
K
N
Q
N
I
M
T
D
A
H
I
E
--
K
I
---------------
L
N
--
A
-
Y
K
S
R
---------------
E
D
I
D
----
K
F
A
H
L
A
S
F
E
E
I
V
E
N
D
Y
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
32.40
27%
13
- C3 -
-
3KHK
-
?
A:
[202-445]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
I
L
G
H
V
Y
E
Y
F
L
G
Q
F
A
L
A
E
-
G
K
Q
G
G
Q
Y
Y
T
P
K
S
I
V
T
L
I
V
E
M
L
---------------
E
---------------------
P
Y
K
G
-
R
V
Y
--------
D
P
A
M
G
S
G
G
F
F
V
S
S
D
K
F
I
----
E
----------------
K
--
H
-------
A
N
V
----------------
K
----
H
Y
N
A
S
E
Q
K
K
----
Q
I
S
V
Y
--
G
Q
E
S
N
P
T
T
W
K
L
A
A
M
-
N
M
V
I
--
R
--
G
I
---------------------
D
---
F
------
N
---------------------
F
G
K
K
------
N
A
---
D
S
F
---
L
---
D
D
Q
H
P
---
D
---
L
RAD
F
V
M
T
N
P
P
F
N
M
K
----
D
W
W
H
E
K
----
L
A
D
-
D
PRW
T
I
N
T
NKRI
L
---
T
----
P
-----------
P
T
G
N
A
N
F
----
A
W
M
-
L
H
M
L
Y
H
L
A
-------
P
-------
T
G
S
M
A
L
L
L
A
N
G
S
M
S
-
S
N
T
-
N
N
E
G
E
I
R
K
T
L
V
-
E
Q
D
L
-----
V
E
C
M
V
A
L
P
G
Q
L
F
T
-------
N
-
T
Q
I
P
A
C
I
W
F
L
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------