@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPX1: (2017-11-23 )
MDFNCDLVWMNSMSALLRFTQFVQKTFALWVIIFAALALWQPEFFVWLKAYIPWILGIIMLGMGMTMTVDDFKGVLQSPKAVLIGVVAQFVVMPGLAFILCKLFNLPPEIAVGVILVGCCPGGTASNVITYMAKGNVALSVACTSVSTLLAPVLTPAIFYLLASQWLKIDAASMFISILQVVLLPIVIGLILRTWLKRQVESYIQVMPLVSVIAIVAIVAAIIGGSKAAILQSGLLILAVVILHNGLGYLLGFAAARFFKLPYADSKAIAVEVGMQNSGLGVALAAVHFAASPITAVPSAIFSLWHNISGPALATYWASKHKQE
Atome Classification :
(20 SA)
-------------------------------------------------------------------....-.....10.--.--......20.----...-----...-------.-30.--------.......--------------40-----......------..50.----------....-------...60...------.....70----.--------..----..-...80.--...----.----...90-------.......--.100------------..--..--....110....-...120-------------------------------.------..-...---------------------...---130-------..----------...--..----..140-..-----..-....150.--------......160------------------.......------------..170-------------..--------.......180---..--...--.-------------...190.--.....-------.200-----------------........210-----------.........220....-------...--230...----------------.----...240.......---------250.....--..-------260.........270---.--.......-280-.......290-------.------------......-----..300.......-310.......---320..----------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------------------------------------MDFN-C
D
L
V
W
M
N
S
--
M
--
S
A
L
L
R
F
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F
----
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-----
T
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A
-------
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------
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----------
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-------
G
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LGMG------
M
T
M
T
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L-QS
P
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-
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GCC---------------------------------P------GG-
T
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----------AKG--
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A
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L
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--FF-------K--LPYADS
K
A
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--VGMQNSG-
L
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FA---------A------------S
P
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P
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L
W
HNIS-G
P
A
L
A
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Y
W
A
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---KHKQE----------------------
1
PsiBlast_PDB
94.22
60%
-178
- C2 -
-
3ZUX
9
?
A:
[7-314]
-------------------------------------------------------------------------------------
N
I
L
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K
I
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----
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----
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---
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P
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G
S
L
L
A
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Y
W
A
A
K
A----------------------------
31
HHSearch
94.15
60%
-176
- C2 -
-
3ZUX
9
?
A:
[7-314]
-------------------------------------------------------------------------------------
N
I
L
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K
I
S
S
F
----
I
G
K
-----
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-------
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A
A
A
A
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--------------
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-----
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----------
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L
L
-------
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I
I
M
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T
L
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S
D
----
F
--------
D
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----
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----
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-------------
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L
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-
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C
C
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---
T
---------
Y
L
----------
A
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----
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------------
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-------------
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---------
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S
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L
A
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Y
W
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---
K
A
-------------------------
32
HHSearch
93.88
60%
-174
- C2 -
-
3ZUY
8
?
A:
[2-309]
-------------------------------------------------------------------------------------
N
I
L
S
K
I
S
S
F
----
I
G
K
-----
T
F
S
-------
L
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--------
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A
A
A
A
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--------------
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A
-----
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D
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------
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Y
I
----------
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W
L
L
-------
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I
I
M
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D
----
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--------
D
I
----
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--
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G
----
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----
I
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Q
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A
-------
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-------------
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L
--
L
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V
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V
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L
-
V
G
C
C
---------------------------------
P
------
G
G
-
T
A
S
---------------------
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---
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---------
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L
----------
A
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--
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----
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--------
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------------
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S
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L
A
T
Y
W
A
A
---
K
A
-------------------------
21
Fugue
93.88
60%
-174
- C2 -
-
3ZUY
8
?
A:
[2-309]
-------------------------------------------------------------------------------------
N
I
L
S
K
I
S
S
F
----
I
G
K
-----
T
F
S
-------
L
-
W
A
A
--------
L
F
A
A
A
A
F
--------------
F
A
-----
P
D
T
F
K
W
------
A
G
P
Y
I
----------
P
W
L
L
-------
G
I
I
M
F
G
M
G
------
L
T
L
K
P
S
D
----
F
--------
D
I
----
L
F
-
K
H
P
K
V
V
--
I
I
G
----
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----
I
A
Q
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A
-------
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-------------
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L
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--
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V
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C
C
---------------------------------
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------
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G
-
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A
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---------------------
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---
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---------
Y
L
----------
A
R
G
--
N
V
----
A
L
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V
--
A
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-----
T
S
-
V
S
T
L
I
S
P
L
--------
L
T
P
A
I
F
L
--------------------
M
L
A
G
E
M
L
------------
E
I
Q
---------------
A
A
--------
G
M
L
M
S
I
V
K
-----
M
V
--
L
L
P
--
I
-------------
V
L
G
L
I
V
H
--
K
V
L
G
S
-------
K
T
E
------------------
K
L
T
D
A
L
P
L
V
-------------
S
V
A
A
I
V
L
I
I
G
A
V
V
G
A
S
-------
K
G
K
--
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M
E
S
G
L
----------------
L
----
I
F
A
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V
V
L
H
N
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I
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Y
---------
L
L
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F
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--
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P
Y
D
A
Q
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T
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----
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V
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Q
N
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G
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L
A
A
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A
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A
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A
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V
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A
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-----
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G
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L
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S
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W
H
N
I
S
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G
S
L
L
A
T
Y
W
A
A
---
K
A
-------------------------
2
PsiBlast_PDB
93.85
60%
-176
- C2 -
-
3ZUY
8
?
A:
[2-309]
-------------------------------------------------------------------------------------
N
I
L
S
K
I
S
S
F
----
I
G
K
-----
T
F
S
-------
L
-
W
A
A
--------
L
F
A
A
A
A
F
--------------
F
A
-----
P
D
T
F
K
W
------
A
G
P
Y
I
----------
P
W
L
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-------
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I
I
M
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M
G
------
L
T
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----
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--------
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I
----
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--
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----
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----
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A
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-------
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-------------
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--
L
N
--
L
P
A
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I
A
V
G
V
I
L
-
V
G
C
C
---------------------------------
P
------
G
G
-
T
A
S
---------------------
N
V
M
---
T
---------
Y
L
----------
A
R
G
--
N
V
----
A
L
S
V
--
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-----
T
S
-
V
S
T
L
I
S
P
L
--------
L
T
P
A
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F
L
--------------------
M
L
A
G
E
M
L
------------
E
I
Q
---------------
A
A
--------
G
M
L
M
S
I
V
K
-----
M
V
--
L
L
P
--
I
-------------
V
L
G
L
I
V
H
--
K
V
L
G
S
-------
K
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E
------------------
K
L
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D
A
L
P
L
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-------------
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A
A
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V
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I
I
G
A
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V
G
A
S
-------
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G
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--
I
M
E
S
G
L
----------------
L
----
I
F
A
V
V
V
L
H
N
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G
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---------
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F
F
A
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--
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-------
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Y
D
A
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I
----
E
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N
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-
L
A
A
-
A
L
A
A
A
H
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A
---------
A
------------
A
P
V
V
A
V
-----
P
G
A
L
F
S
V
W
H
N
I
S
-
G
S
L
L
A
T
Y
W
A
A
K
A----------------------------
11
PsiBlast_CBE
83.62
38%
-164
- C2 -
-
4N7W
2
?
B:
[5-306]
--------------------------------------------------------------------------------------------------
I
T
R
-----
L
F
P
-------
V
-
W
A
L
--------
L
L
S
V
A
A
Y
--------------
F
R
-----
P
T
T
F
T
G
------
I
G
P
Y
V
----------
G
P
L
L
-------
M
L
I
M
F
A
M
G
------
V
T
L
R
L
D
D
----
F
--------
K
R
----
V
L
-
S
R
P
A
P
V
--
A
A
A
----
T
----
F
L
H
Y
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-------
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M
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--
I
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-------------
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L
--
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M
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P
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L
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G
M
V
L
-
V
G
S
V
---------------------------------
A
------
S
G
-
T
A
S
---------------------
N
V
M
---
I
---------
Y
L
----------
A
K
G
--
D
V
----
A
L
S
V
--
T
I
-----
S
A
-
V
S
T
L
V
G
V
F
--------
A
T
P
L
L
T
R
--------------------
L
Y
V
D
A
T
I
------------
S
V
D
---------------
V
V
--------
G
M
L
K
S
I
L
Q
-----
I
V
--
V
I
P
--
I
-------------
T
A
G
L
V
I
H
--
H
T
F
T
K
-------
T
V
K
------------------
R
I
E
P
Y
L
P
A
M
-------------
S
M
V
C
I
L
A
I
I
S
A
V
V
A
G
S
-------
Q
S
H
--
I
A
S
V
G
F
----------------
V
----
V
I
I
A
V
I
L
H
N
G
I
G
L
---------
L
S
G
Y
W
G
G
K
--
L
F
-------
G
--
F
D
E
S
T
C
R
T
L
A
I
----
E
--
V
G
M
Q
N
S
G
-
L
A
A
-
T
L
G
K
I
Y
F
-----------------------
S
P
L
A
A
L
-----
P
G
A
L
F
S
V
W
H
N
L
S
-
G
S
L
L
A
G
Y
W
S
G
KPV
K
K
D
Q
-----------------------
4
PsiBlast_PDB
82.87
38%
-173
- C2 -
-
4N7X
-
?
A:
[5-300]
--------------------------------------------------------------------------------------------------
I
T
R
-----
L
F
P
-------
V
-
W
A
L
--------
L
L
S
V
A
A
Y
--------------
F
R
-----
P
T
T
F
T
G
------
I
G
P
Y
V
----------
G
P
L
L
-------
M
L
I
M
F
A
M
G
------
V
T
L
R
L
D
D
----
F
--------
K
R
----
V
L
-
S
R
P
A
P
V
--
A
A
A
----
T
----
F
L
H
Y
L
-------
I
M
P
L
T
A
W
--
I
L
A
-------------
M
L
--
F
R
--
M
P
P
D
L
S
A
G
M
V
L
-
V
G
S
V
---------------------------------
A
------
S
G
-
T
A
S
---------------------
N
V
M
---
I
---------
Y
L
----------
A
K
G
--
D
V
----
A
L
S
V
--
T
I
-----
S
A
-
V
S
T
L
V
G
V
F
--------
A
T
P
L
L
T
R
--------------------
L
Y
V
D
A
T
I
------------
S
V
D
---------------
V
V
--------
G
M
L
K
S
I
L
Q
-----
I
V
--
V
I
P
--
I
-------------
T
A
G
L
V
I
H
--
H
T
F
T
K
-------
T
V
K
------------------
R
I
E
P
Y
L
P
A
M
-------------
S
M
V
C
I
L
A
I
I
S
A
V
V
A
G
S
-------
Q
S
H
--
I
A
S
V
G
F
----------------
V
----
V
I
I
A
V
I
L
H
N
G
I
G
L
---------
L
S
G
Y
W
G
G
K
--
L
F
-------
G
--
F
D
E
S
T
C
R
T
L
A
I
----
A
--
V
G
M
Q
N
S
G
-
L
A
A
-
T
L
G
K
I
Y
F
-----------------------
S
P
L
A
A
L
-----
P
G
A
L
F
S
V
W
H
N
L
S
-
G
S
L
L
A
G
Y
W
S
G
---
K
--------------------------
33
HHSearch
82.25
38%
-165
- C2 -
-
4N7W
2
?
A:
[2-304]
-------------------------------------------------------------------------------------------
L
V
K
----
I
T
R
-----
L
F
P
-------
V
-
W
A
L
--------
L
L
S
V
A
A
Y
--------------
F
R
-----
P
T
T
F
T
G
------
I
G
P
Y
V
----------
G
P
L
L
-------
M
L
I
M
F
A
M
G
------
V
T
L
R
L
D
D
----
F
--------
K
R
----
V
L
-
S
R
P
A
P
V
--
A
A
A
----
T
----
F
L
H
Y
L
-------
I
M
P
L
T
A
W
--
I
L
A
-------------
M
L
--
F
R
--
M
P
P
D
L
S
A
G
M
V
L
-
V
G
S
V
---------------------------------
A
------
S
G
-
T
A
S
---------------------
N
V
M
---
I
---------
Y
L
----------
A
K
G
--
D
V
----
A
L
S
V
--
T
I
-----
S
A
-
V
S
T
L
V
G
V
F
--------
A
T
P
L
L
T
R
--------------------
L
Y
V
D
A
T
I
------------
S
V
D
---------------
V
V
--------
G
M
L
K
S
I
L
Q
-----
I
V
--
V
I
P
--
I
-------------
T
A
G
L
V
I
H
--
H
T
F
T
K
-------
T
V
K
------------------
R
I
E
P
Y
L
P
A
M
-------------
S
M
V
C
I
L
A
I
I
S
A
V
V
A
G
S
-------
Q
S
H
--
I
A
S
V
G
F
----------------
V
----
V
I
I
A
V
I
L
H
N
G
I
G
L
---------
L
S
G
Y
W
G
G
K
--
L
F
-------
G
--
F
D
E
S
T
C
R
T
L
A
I
----
E
--
V
G
M
Q
N
S
G
-
L
A
A
-
T
L
G
K
I
Y
F
S
-----------------------
P
L
A
A
L
-----
P
G
A
L
F
S
V
W
H
N
L
S
-
G
S
L
L
A
G
Y
W
S
G
---
K
P
V
K
K
----------------------
3
PsiBlast_PDB
81.88
38%
-163
- C2 -
-
4N7W
2
?
A:
[5-307]
--------------------------------------------------------------------------------------------------
I
T
R
-----
L
F
P
-------
V
-
W
A
L
--------
L
L
S
V
A
A
Y
--------------
F
R
-----
P
T
T
F
T
G
------
I
G
P
Y
V
----------
G
P
L
L
-------
M
L
I
M
F
A
M
G
------
V
T
L
R
L
D
D
----
F
--------
K
R
----
V
L
-
S
R
P
A
P
V
--
A
A
A
----
T
----
F
L
H
Y
L
-------
I
M
P
L
T
A
W
--
I
L
A
-------------
M
L
--
F
R
--
M
P
P
D
L
S
A
G
M
V
L
-
V
G
S
V
---------------------------------
A
------
S
G
-
T
A
S
---------------------
N
V
M
---
I
---------
Y
L
----------
A
K
G
--
D
V
----
A
L
S
V
--
T
I
-----
S
A
-
V
S
T
L
V
G
V
F
--------
A
T
P
L
L
T
R
--------------------
L
Y
V
D
A
T
I
------------
S
V
D
---------------
V
V
--------
G
M
L
K
S
I
L
Q
-----
I
V
--
V
I
P
--
I
-------------
T
A
G
L
V
I
H
--
H
T
F
T
K
-------
T
V
K
------------------
R
I
E
P
Y
L
P
A
M
-------------
S
M
V
C
I
L
A
I
I
S
A
V
V
A
G
S
-------
Q
S
H
--
I
A
S
V
G
F
----------------
V
----
V
I
I
A
V
I
L
H
N
G
I
G
L
---------
L
S
G
Y
W
G
G
K
--
L
F
-------
G
--
F
D
E
S
T
C
R
T
L
A
I
----
E
--
V
G
M
Q
N
S
G
-
L
A
A
-
T
L
G
K
I
Y
F
-----------------------
S
P
L
A
A
L
-----
P
G
A
L
F
S
V
W
H
N
L
S
-
G
S
L
L
A
G
Y
W
S
G
KPV
K
K
D
Q
E
----------------------
27
Fugue
55.33
19%
-128
- C2 -
-
4CZB
-
NAH1_METJA
A:
[1-415]
-------------------------------------------------------------------
M
E
L
M
-
M
A
I
G
Y
L
G
L
--
A
--
L
V
L
G
S
L
V
A
K
----
I
A
E
K
L
KIP
D
I
P
-------
L
-
L
L
L
--------
L
G
L
I
I
G
P
--------------
F
L
QIIP
S
D
S
A
M
E
I
------
F
E
Y
A
G
----------
P
I
G
L
-------
I
F
I
L
L
G
G
A
------
F
T
M
R
I
S
L
----
L
--------
K
R
----
V
I
-
K
T
--
V
V
--
R
L
D
----
T
----
I
T
F
L
I
-------
T
L
L
I
S
G
F
--
I
F
N
-------------
M
V
--
L
N
--
L
P
Y
T
S
P
V
G
Y
L
F
-
G
A
I
T
A
A
T
D
P
A
T
L
I
P
V
F
S
R
V
RTN
P
E
V
A
I
T
L
E
A
E
S
I
F
N
D
P
------
L
G
-
I
V
S
---------------------
T
S
V
---
I
---------
L
G
L
F
GLFSSSN
P
L
I
D
--
L
I
----
T
L
A
G
--
G
A
-----
I
V
-
V
G
L
L
L
A
K
I
--------
Y
E
K
I
I
I
H
--------------------
C
D
F
H
E
Y
V
------------
A
P
L
---------------
V
L
--------
G
G
A
M
L
L
L
Y
-----
V
G
DD
L
L
P
--
S
I
CG
Y
G
F
S
G
Y
M
A
V
A
I
M
G
L
Y
L
G
--
D
A
L
F
R
A
DDID
Y
K
Y
I
V
------------------
S
F
C
D
D
L
S
L
L
-------------
A
R
V
F
I
F
V
F
L
G
A
C
I
K
L
S
-------
M
L
E
N
Y
F
I
P
G
L
L
----------------
V
----
A
L
G
S
I
F
L
A
R
P
L
G
V
---------
F
L
G
L
I
G
S
K
--
H
------------
S
F
K
E
K
L
Y
F
A
L
----
E
G
P
R
G
V
V
P
A
A
-
L
A
V
-
T
V
G
I
E
I
L
K
---------
N
ADKIPA
S
I
T
K
Y
I
T
P
T
D
I
A
-----
G
T
I
I
I
G
T
F
M
T
I
L
L
S
V
I
L
E
A
S
W
A
G
---
M
L
A
L
K
L
LGE------------------
25
Fugue
49.04
16%
-166
- C2 -
-
4XNV
14
P2RY1_HUMAN (first)
A:
[38-382]
--------------------------------------------------------------------
S
F
K
-
C
A
L
T
K
T
G
---------
F
Q
F
Y
Y
L
----
P
A
V
-----
Y
I
L
-------
V
-
F
I
I
--------
G
F
L
G
N
S
V
--------------
A
I
-----
W
M
F
V
F
H
------
M
K
-------------
P
W
---------------
S
G
------
I
S
V
Y
M
F
N
----
L
--------
A
L
----
A
D
-
F
L
Y
V
L
T
--
L
P
A
----
L
----
I
F
Y
Y
F
-------
N
K
T
D
W
I
F
G
D
A
M
C
-------------
K
L
Q
R
F
I
--
F
H
V
N
L
Y
G
S
I
L
F
-
L
T
C
I
---------------------------------
S
------
A
H
-
R
Y
S
---------------------
G
V
V
YPK
S
---------
L
G
----------
R
L
K
--
K
K
----
N
A
I
C
--
I
S
-----
V
L
-
V
W
L
I
V
V
V
A
--------
I
S
P
I
L
F
Y
S
G
T
G
V
R
KNKTITCYDTTSDE
Y
L
R
S
Y
F
I
------------
Y
S
M
---------------
C
T
--------
T
V
A
M
F
C
V
P
-----
L
V
--
L
I
L
--
G
-------------
C
Y
G
L
I
V
R
--
A
L
I
Y
K
-------
M
K
K
------------------
Y
T
C
T
V
C
G
Y
I
Y
N
PEDGDPDNGVN
P
G
T
D
F
K
D
I
V
C
P
L
C
G
V
G
-------
K
D
Q
--
F
E
E
V
E
--------------------------
E
P
L
R
R
K
S
I
Y
---------
L
V
I
I
V
L
T
V
--
F
A
-------
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
----
R
--
A
R
L
D
F
Q
T
-
P
A
M
C
A
F
N
D
R
V
Y
A
---------
T
------------
Y
Q
V
T
R
G
-----
L
A
S
L
N
S
C
V
N
-----
P
I
L
Y
F
L
A
G
D
---
T
F
R
R
R
----------------------
10
PsiBlast_PDB
44.33
27%
-178
- C- -
-
1QLV
-
2PS_GERHY
A:
[104-202]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
-------
G
V
P
M
L
G
K
E
------
A
A
V
K
A
I
D
----
E
--------
W
G
----
L
P
-
K
S
K
I
T
H
--
L
I
F
----
C
----
T
T
A
G
V
-------
D
M
P
G
A
D
Y
--
Q
L
V
-------------
K
L
--
L
G
--
L
S
P
S
V
K
R
Y
M
L
Y
Q
Q
G
-
A
---------------------------------
A
------
G
G
-
T
V
L
---------------------
R
L
A
---
K
---------
D
L
----------
A
E
N
--
N
K
----
G
S
R
V
L
I
V
C
-----
S
E
-
I
T
A
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
43.59
14%
-106
- C2 -
-
5F0J
10
VPS35_HUMAN
A:
[4-461]
GS
K
L
L
D
E
A
I
Q
A
V
K
V
Q
S
F
Q
M
K
R
C
L
D
K
NK
L
M
D
A
L
K
H
A
S
N
M
L
GELRTSMLS
P
K
S
Y
Y
E
L
Y
M
A
I
S
D
E
L
H
Y
L
E
V
Y
L
T
-
D
E
F
A
K
G
R
K
--
V
--
A
D
L
Y
E
L
V
Q
Y
AGN
I
I
P
R
-----
L
Y
L
-------
L
-
I
T
V
--------
G
V
V
Y
V
K
S
--------------
F
P
-----
Q
S
R
K
D
I
------
L
K
D
L
V
----------
E
M
C
R
GVQH
P
L
R
G
L
F
L
R
N
Y
L
------
L
Q
C
T
R
N
I
----
L
PDEGEPTD
E
E
----
T
T
-
G
D
I
S
D
S
--
M
D
F
----
V
----
L
L
N
F
A
-------
E
M
N
K
L
W
V
--
R
M
Q
H
QGHSRD
R
E
K
R
E
R
E
R
--
Q
E
--
L
R
I
L
V
G
T
N
L
V
R
-
L
S
Q
L
---------------------------------
E
------
G
V
-
N
V
E
---------------------
R
Y
K
---
Q
---------
I
V
----------
L
T
G
--
I
L
----
E
Q
V
V
--
N
C
-----
R
D
---
A
L
A
Q
E
Y
--------
L
M
E
C
I
I
Q
--------------------
V
F
-
P
D
E
F
------------
H
L
Q
---------------
T
L
--------
N
P
F
L
R
A
C
A
E
LHQN
V
N
--
V
K
N
--
I
-------------
I
I
A
L
I
D
R
--
L
A
L
F
A
-------
H
R
E
------------------
D
G
P
G
I
P
A
D
I
-------------
K
L
F
D
I
F
S
Q
Q
V
A
T
V
I
Q
S
RQDMP
S
E
D
V
V
--
S
L
Q
V
S
L
----------------
I
----
N
L
A
M
K
C
Y
P
D
R
V
D
Y
---------
V
D
K
V
L
E
T
T
--
V
E
-------
I
--
F
N
K
L
N
L
E
H
I
A
T
----
S
---
S
A
V
S
K
E
-
L
T
R
-
L
L
K
I
P
V
D
T
---------
Y
------------
N
N
I
L
T
V
L
K
LKH
F
H
P
L
F
E
Y
F
D
Y
E
S
-
R
K
S
M
S
C
Y
V
L
S
---
N
V
L
D
Y
NTEIVS
Q
D
Q
V
D
S
I
M
N
L
V
S
T
L
I
Q
23
Fugue
41.76
16%
-79
- C2 -
-
1E6Y
4
MCRB_METBF
B:
[1-432]
------------------------------------------------------S
D
T
V
D
I
Y
D
DRGKL
L
E
S
N
-
V
D
I
M
S
L
A
P
--
T
RN
A
A
I
Q
S
I
I
M
D
----
T
K
R
-----
S
V
A
-------
V
N
L
A
G
--------
I
Q
G
A
L
A
S
GKMGGKG
R
Q
I
L
GR
G
L
N
-----
Y
D
I
V
G
N
------
A
D
A
I
A
----------
E
N
V
K
-------
K
L
V
Q
V
D
E
G
------
D
D
T
N
V
I
K
----
V
--------
K
G
GK
S
L
L
I
-
Q
S
P
K
S
R
--
I
I
A
----
G
ADFM
S
A
T
T
V
-------
G
A
A
A
V
T
Q
--
T
I
M
-------------
D
M
--
F
G
TD
P
Y
D
A
P
I
V
K
S
A
V
-
W
G
S
Y
---------------------------------
P
QTMDLM
G
G
-
Q
V
Q
GILSIPQNNEGLGFSLRNIM
A
N
H
V
---
A
---------
A
I
----------
S
N
R
--
N
A
----
M
N
A
S
--
A
L
-----
S
S
-
I
Y
E
Q
S
G
I
F
E
M
GGAV
G
M
F
E
R
H
Q
L
L
--------------------
G
L
A
Y
Q
G
L
------------
N
A
N
N
L
L
Y
D
I
V
K
E
N
GKDGT
I
G
--------
T
V
I
E
S
V
V
R
-----
R
A
--
I
E
A
GI
I
-------------
S
V
D
K
T
A
P
--
S
G
Y
N
F
-------
Y
K
A
------------------
N
D
V
P
K
W
N
A
C
-------------
A
A
V
G
T
L
A
A
T
L
V
N
C
G
A
G
-------
R
A
A
--
Q
N
V
S
S
T
----------------
L
----
L
Y
F
N
D
I
L
E
K
E
T
G
L
PGCDYG
K
V
E
G
T
A
V
G
F
S
F
--
F
S
-------
H
--
S
I
Y
G
G
G
G
P
G
V
F
NGNH
V
--
V
T
R
H
S
R
G
-
F
A
I
-
P
C
V
C
A
A
V
A
L
DAGTQMFS
I
------------
E
S
T
S
G
L
-----
I
G
D
V
F
G
A
I
P
E
F
R
-
E
P
I
K
A
V
A
G
V
-------------------------------
22
Fugue
40.48
14%
-96
- C2 -
-
1HBN
4
MCRB_METTM
B:
[1-442]
-------------------------------------------------AKFE
D
K
V
D
L
Y
D
DRGNLVE
E
Q
V
P
-
L
E
A
L
S
P
L
R
--
N
--
P
A
I
K
S
I
V
Q
G
----
I
K
R
-----
T
V
A
-------
V
N
L
E
G
--------
I
E
N
A
L
K
T
AKVGGPA
C
K
I
M
GR
E
L
D
-----
L
D
I
V
G
N
------
A
E
S
I
A
----------
A
A
A
K
-------
E
M
I
Q
V
T
E
D
------
D
D
T
N
V
E
L
----
L
--------
G
G
GK
R
A
L
V
-
Q
V
P
S
A
R
--
F
D
V
AAEY
S
----
A
A
P
L
V
-------
T
A
T
A
F
V
Q
--
A
I
I
-------------
N
E
--
F
D
VS
M
Y
D
A
N
M
V
K
A
A
V
-
L
G
R
Y
---------------------------------
P
QSVEYM
G
A
-
N
I
A
---------------------
T
M
L
---
D
IPQKLEGPG
Y
A
----------
L
R
N
--
I
M
----
V
N
H
V
--
V
A
A
T
LKN
T
L
-
Q
A
A
A
L
S
T
I
--------
L
E
Q
T
A
M
F
E
M
GDAVGAF
E
R
M
H
-------
L
L
G
L
A
Y
Q
------------
G
M
N
---------------
A
D
--------
N
L
V
F
D
L
V
K
-----
A
N
--
G
K
E
--
G
-------------
T
V
G
S
V
I
A
--
D
L
V
E
R
-------
A
L
E
D
GVIKVEKELTD
Y
K
V
Y
G
T
D
D
L
A
M
W
N
A
Y
-------------
A
A
A
G
L
M
A
A
T
M
V
N
Q
G
A
A
-------
R
A
A
--
Q
G
V
S
S
T
----------------
L
----
L
Y
Y
N
D
L
I
E
F
E
T
G
L
PSVDFG
K
V
E
G
T
A
V
G
F
S
F
--
F
S
-------
H
--
S
I
Y
G
G
G
G
P
G
I
F
NGNH
I
--
V
T
R
H
S
K
G
-
F
A
I
-
P
C
V
A
A
A
M
A
L
DAGTQMFS
P
------------
E
A
T
S
G
L
-----
I
K
E
V
F
S
Q
V
D
E
F
R
-
E
P
L
K
Y
V
V
E
A
A
---
A
E
I
K
N
EI--------------------
40
HHSearch
39.57
14%
-186
- C2 -
-
4N7W
1
?
A:
[80-108]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
I
L
A
M
--
L
F
-------
R
--
M
P
P
D
L
S
A
G
M
V
L
----
V
--
G
S
V
A
S
G
T
-
A
S
------------------------------------------------------------------------------------------------
26
Fugue
34.17
18%
-79
- C2 -
-
4LL8
-
MYO4_YEAST
A:
[1016-1468]
---------------------------------------------------ERA
A
A
Q
S
S
L
I
Q
S
H
M
Q
S
L
A
A
N
-
K
P
S
R
L
S
D
E
--
V
--
K
S
M
K
Q
E
L
A
F
----
I
E
N
-----
V
I
A
QA
N
K
P
K
L
V
-
N
V
I
R
R
E
SGN
P
D
L
L
E
L
L
M
D
--------------
L
N
-----
S
Y
T
L
E
V
------
T
E
G
Y
L
KKVNVTEVNG
D
N
V
L
-------
G
P
I
H
V
I
T
T
------
V
V
S
S
L
V
R
----
N
--------
G
L
----
L
I
-
Q
S
S
K
F
I
S
K
V
L
L
----
T
----
V
E
S
I
V
M
S
LPKDE
T
M
L
G
G
I
F
--
W
L
S
-------------
N
L
--
S
R
--
L
P
A
F
A
A
N
Q
K
T
L
-
Y
E
A
N
---------------------------------
G
------
G
D
-
E
K
D
---------------------
K
L
T
---
L
---------
I
Y
----------
L
N
D
L
E
N
E
----
T
L
K
V
--
F
D
-----
K
I
-
Y
S
T
W
L
V
K
F
--------
M
K
H
A
S
A
H
--------------------
I
E
I
F
D
M
V
LNEKLFKN
S
G
D
E
K
F
A
---------------
K
L
--------
F
T
F
L
N
E
F
D
-----
A
V
--
L
S
K
--
F
-------------
Q
V
V
D
S
M
H
--
T
K
I
F
N
-------
D
T
L
------------------
K
Y
L
N
V
M
L
F
N
-------------
D
L
I
T
K
S
P
A
L
N
W
K
Y
G
Y
E
-------
V
D
R
--
N
I
E
R
L
V
S
WFEPRIEDVRPNLI
Q
I
----
I
Q
A
V
K
I
L
Q
L
K
I
S
N
---------
L
N
E
F
K
L
L
F
DF
W
Y
-------
A
--
L
N
P
A
Q
I
Q
A
I
L
L
----
K
--
Y
K
P
A
N
K
G
E
A
G
V
-
P
N
E
I
L
N
Y
L
---------
A
------------
N
V
I
K
R
E
-----
N
L
S
L
P
G
K
M
E
I
M
L
-
S
A
Q
F
D
S
A
K
N
H
---
L
R
Y
D
T
S
A
I
T
Q
N
S
N
T
E
G
L
A
T
V
S
K
I
I
KL-
24
Fugue
31.68
14%
-136
- C2 -
-
2R9R
9
KCNA2_RAT (first)
B:
[51-436]
------------------------------S
E
R
V
V
I
N
I
SG
L
R
F
E
T
Q
L
K
T
L
A
Q
FPETLLGDPKKRMRY
F
D
P
L
-
R
N
E
Y
F
F
D
R
N-
R
--
P
S
F
D
A
I
L
Y
Y
----
Y
Q
S
-----
G
G
R
-------
L
-
R
R
P
--------
V
N
V
P
L
D
I
--------------
F
S
-----
E
E
I
R
F
Y
ELG
E
E
A
M
E
M
F
R
----------
E
D
E
G
-------
Y
I
K
E
E
E
R
P
L
PENEF
Q
R
Q
V
W
L
L
----
F
--------
E
Y
----
P
E
-
S
S
G
P
A
R
--
I
I
A
----
I
----
V
S
V
M
V
-------
I
L
I
S
I
V
S
--
F
C
L
-------------
E
T
-------
L
P
I
F
R
D
E
N
----------------------------------------
E
------
D
M
-
H
G
G
---------------------
G
V
T
---
F
---------
H
T
----------
Y
S
Q
--
S
T
----
I
G
Y
Q
--
Q
S
-----
T
S
-
F
T
D
P
F
F
I
V
--------
E
T
L
C
I
I
W
--------------------
F
S
F
E
F
L
V
------------
R
F
F
---------------
A
C
PSKAGFFT
N
I
M
N
I
I
D
I
-----
V
A
--
I
I
P
--
Y
-------------
Y
V
T
I
F
L
T
E
S
N
K
S
V
L
-------
Q
F
Q
------------------
N
V
R
R
V
V
Q
I
F
-------------
R
I
M
R
I
L
R
I
F
K
L
S
R
H
S
K
-------
G
L
Q
--
I
L
G
Q
T
L
----------------
K
A
S
M
R
E
L
G
L
L
I
F
F
L
F
I
G
V
---------
I
L
F
S
S
A
V
Y
--
F
A
E
ADERDS
Q
--
F
P
S
I
P
D
A
F
W
W
A
----
V
--
V
S
M
T
T
V
G
-
Y
G
--
D
M
V
P
T
T
I
G
---------
G
------------
K
I
V
G
S
L
-----
C
A
I
A
G
V
L
T
I
A
L
P
-
V
P
V
I
V
S
N
F
N
Y
---
F
Y
H
R
E
T---------------------
39
HHSearch
31.59
12%
-155
- C2 -
-
1ZCD
-
NHAA_ECOLI
A:
[59-171]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------
L
L
W
I
N
----------
D
A
L
M
-------
A
V
F
F
L
L
V
G
------
L
E
V
K
R
E
L
M
QGS
L
--------
A
S
----
L
R
-
Q
A
A
--
F
--
P
V
I
----
A
----
A
I
G
G
M
-------
I
V
P
A
L
L
Y
--
L
A
F
-------------
N
Y
---
A
---
D
P
I
T
R
E
G
W
A
I
-
P
A
A
T
---------------------------------
D
------
I
A
-
F
A
L
---------------------
G
V
L
---
A
---------
L
L
----------
G
S
R
--
V
P
L
A
L
K
I
F
L
M
--
A
L
-----
A
I
-
I
D
D
L
G
A
I
I
--------
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
28.73
15%
-
- C2 -
-
3U4T
-
?
A:
[230-487]
-------------------------------------------------------------------
V
E
F
R
Y
A
D
F
L
F
K
N
N
N
Y
A
--
E
A
I
E
V
F
N
K
L
----
E
A
K
-----
K
Y
N
S------
P
-
Y
I
Y
--------
N
R
R
A
V
C
Y
--------------
Y
E
-----
L
A
K
Y
D
L
------
A
Q
K
D
I
----------
E
T
Y
F
-------
S
K
V
N
A
T
K
A
------
K
S
A
D
F
E
Y
----
Y
--------
G
K
----
I
L
M
K
K
G
Q
D
S
--
L
A
I
----
Q
----
Q
Y
Q
A
A
-------
V
D
R
D
T
T
R
--
L
--------------------------------------------------------------------------------
D
M
Y
G
Q
---------------------
I
G
S
---
Y
---------
F
Y
----------
N
K
G
--
N
F
----
P
L
A
I
--
Q
-------
Y
M
E
K
Q
I
R
P
T
T
--------
T
D
P
K
V
F
Y
--------------------
E
L
G
Q
A
Y
Y
Y
N
KE--------
Y
V
K
---------------
A
D
--------
S
S
F
V
K
V
L
E
-----
L
K
--
P
-
N
--
I
-------------
Y
I
G
Y
L
W
R
--
A
R
A
N
A
-------
A
Q
D
------------------
P
D
T
K
Q
G
L
A
K
-------------
P
Y
Y
E
K
L
I
E
V
C
A
P
G
G
A
K
-------
Y
K
D
--
E
L
I
E
A
N
----------------
E
----
Y
I
A
Y
Y
Y
T
I
N
R
D
K
V
---------
K
A
D
A
A
W
K
N
--
I
L
-------
A
--
L
D
P
T
N
K
K
A
I
D
G
----
L
--
K
---------------------------------------------------------------------------------------------------------