@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VPY7: (2017-11-24 )
MPEFSFSDALLNWFDQHGRHDLPWQVADDPYKVWVSEIMLQQTQVKTVLQYFDRFMERFPTVEALGHATWDEVAPYWAGLGYYARARNLHKAASLVAQQGKFPETLEEWIALPGIGRSTAGALMSLGLRQYGVIMDGNVKRVLARFFAIEDDLSKPQHEREMWKLAEELCPTHRNHDYTQAIMDLGATICTPKKPLCLYCPMQAHCQAYQQGLEQELPFKKPKKTPPVKTADVLIIQCEDEWFWQQRQAHGLWGGLFCLPILENEHERLKLSQQFKLQPRPQTFQISHSFTHFTWLLNAHVFHVEPDQKEHLAIELEGQWLSPEQAIAKGVPTAMKKLISTSRS
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90......--.--.--100.......110.......120.......130.---......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.....-..240--.......250.......260...----....270.....-----....280.....--..290.......300.......310.......320.......330.......340..--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPEFS
F
S
D
A
L
L
N
W
F
D
QHGRHDLPWQVAD
D
P
Y
K
V
W
V
S
E
I
M
L
Q
Q
T
Q
V
K
T
V
L
Q
Y
F
D
R
F
M
E
RFP
T
V
E
A
LGHA
T
W
D
E
V
A
P
Y
W
A
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
S
L
V
A
--Q--Q--GK
F
P
E
T
L
E
E
W
IALPGIG
R
S
T
A
G
A
L
M
S
L
G
L
R
QY
G
V
---IMDG
N
V
K
R
V
L
A
R
F
F
AIEDDLSK
P
Q
H
E
R
E
M
W
K
L
A
E
E
LCPTHRNH
D
Y
T
Q
A
I
M
DLGATICTPKK
P
L
C
L
YCP
M
Q
A
H
C
Q
A
Y
Q
Q
G
L
E
QELPFKKPKKTPPVK
T
A
D
V
L
I
I
Q
-CE
D
E
W
--
F
W
Q
Q
R
QAHGLWG
G
L
F
C
L
PILEN
E
----
H
E
R
L
K
--
L
S
Q
QF-----KLQPRP
Q
T
F
Q
I
S--HSF
T
H
F
T
W
L
L
N
A
H
V
F
H
VEPDQK
E
H
L
A
I
E
L
EGQWL
S
P
E
Q
A
I
A
KG
V
P
T
A
M
K
K
L
I
STSRS--
50
Fugue
81.86
35%
-11
- C4 -
-
1RRQ
3
MUTY_GEOSE
A:
[12-362]
-
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
--
T
--
R
YG
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
---
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
---
V
K
M
V
K
Q
V
P
L
A
V
A
V
L
A
D
-
D
E
G
R
V
--
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
GADG
K
E
K
L
E
--
Q
M
V
G
L
-----
Q
V
E
L
T
E
P
I
V
S
F
E
--
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
G
P
V
----
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
22
PsiBlast_CBE
81.27
40%
-33
- C4 -
-
4YPR
5
MUTY_GEOSE
A:
[11-319]
F
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
-
R
R
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
--
T
--
R
YG
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
---
Y
G
V
PEP
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
-
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
-
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
GADG
K
E
K
L
E
Q
M
V
G
E
Q
Y
-----
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
-----------------------------------------------
14
PsiBlast_PDB
81.12
40%
-34
- C4 -
-
3FSP
3
MUTY_GEOSE
A:
[11-319]
F
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
-
R
R
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
--
T
--
R
YG
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
---
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
-
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
-
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
GADG
K
E
K
L
E
Q
M
V
G
E
Q
Y
-----
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
-----------------------------------------------
27
HHSearch
79.84
35%
-23
* C4 *
-
3G0Q
3
MUTY_GEOSE
A:
[2-347]
--
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
R
-
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
--
T
R
Y
G
--
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
---
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
----
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
--
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
-----
G
A
D
G
--
K
E
K
L
E
QMVGL
Q
V
E
L
T
E
P
I
V
S
F
E
--
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
----
G
P
V
E
E
P
Y
R
L
A
P
E
D
E
L
K
A
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
----
21
PsiBlast_CBE
79.81
40%
-37
- C4 -
-
4YPR
3
MUTY_GEOSE
B:
[11-319]
F
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
-
R
R
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
--
T
--
R
YG
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
---
Y
G
V
PEP
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
-
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
-
A
D
D
E
G
RV
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
GADG
K
E
K
L
E
QM
V
G
----------
Q
V
E
L
T
E
P
I
V
S
FE
H
A
F
S
H
L
V
W
Q
L
T
V
-----------------------------------------------
17
PsiBlast_PDB
78.89
40%
-40
- C4 -
-
4YOQ
4
MUTY_GEOSE
A:
[12-319]
-
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
-
R
R
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
--
T
--
R
YG
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
---
Y
G
V
PEP
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
-----
V
K
Q
V
P
L
A
V
A
V
L
-
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
GADG
K
E
K
L
E
Q
M
V
---------
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
-----------------------------------------------
13
PsiBlast_PDB
78.88
40%
-36
- C4 -
-
5DPK
3
MUTY_GEOSE
A:
[8-316]
F
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
-
R
R
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
--
T
--
R
YG
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
---
Y
G
V
PEP
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
-
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
-
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
GAD
G
K
E
K
L
E
Q
M
V
G
E
Q
----------
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
-----------------------------------------------
20
PsiBlast_PDB
78.12
40%
-44
- C4 -
-
1RRQ
3
MUTY_GEOSE
A:
[12-319]
-
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
-
R
R
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
--
T
--
R
YG
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
---
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
-----
V
K
Q
V
P
L
A
V
A
V
L
-
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
GADG
K
E
K
L
E
Q
M
V
---------
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
-----------------------------------------------
16
PsiBlast_PDB
78.01
40%
-31
- C4 -
-
1VRL
4
MUTY_GEOSE
A:
[12-319]
-
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
-
R
R
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
--
T
--
R
YG
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
---
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
-
K
K
T
A
V
K
Q
V
P
L
A
V
A
V
L
-
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
DG--
K
E
K
L
E
Q
M
V
---------
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
-----------------------------------------------
18
PsiBlast_PDB
77.90
40%
-42
- C4 -
-
4YPH
3
MUTY_GEOSE
A:
[12-319]
-
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
-
R
R
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
--
T
--
R
YG
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
---
Y
G
V
PEP
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
-----
V
K
Q
V
P
L
A
V
A
V
L
-
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
GADG
K
E
K
L
E
Q
M
V
---------
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
-----------------------------------------------
15
PsiBlast_PDB
77.79
40%
-38
- C4 -
-
1RRS
3
MUTY_GEOSE
A:
[12-319]
-
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
-
R
R
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
--
T
--
R
YG
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
---
Y
G
V
PEP
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
-
K
---
V
K
Q
V
P
L
A
V
A
V
L
-
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
GADG
K
E
K
L
E
Q
M
V
---------
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
-----------------------------------------------
28
HHSearch
77.36
55%
-43
- C4 -
-
1KQJ
4
MUTY_ECOLI
A:
[1-225]
M
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
--
T
LH
G
--
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
---
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
H
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
77.11
40%
-44
- C4 -
-
3G0Q
3
MUTY_GEOSE
A:
[1-308]
-
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
-
R
R
D
L
P
W
R
K
D
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
--
T
--
R
YG
G
K
V
P
D
D
P
D
E
F
S
R
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
---
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
E
E
L
P
V
K
M
-----
V
K
Q
V
P
L
A
V
A
V
L
-
A
D
D
E
G
R
V
L
I
R
K
R
D
S
T
G
L
L
A
N
L
W
E
F
P
S
C
E
T
D
GADG
K
E
K
L
E
QM
V
---------
G
L
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
-----------------------------------------------
10
PsiBlast_PDB
76.74
55%
-52
- C4 -
-
1KG4
3
MUTY_ECOLI
A:
[6-224]
-----
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
--
G
--
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
---
I
L
D
G
N
V
A
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
--------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
76.53
55%
-42
- C4 -
-
1KQJ
4
MUTY_ECOLI
A:
[6-225]
-----
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
--
G
--
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
---
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
H
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.32
55%
-46
- C4 -
-
1MUD
4
MUTY_ECOLI
A:
[6-225]
-----
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
--
G
--
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
---
I
L
N
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.27
55%
-52
- C4 -
-
1KG6
5
MUTY_ECOLI
A:
[6-224]
-----
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
--
G
--
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
---
I
L
D
G
N
V
R
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
--------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
76.17
55%
-49
- C4 -
-
1MUY
4
MUTY_ECOLI
A:
[6-225]
-----
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
--
G
--
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
---
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
76.05
55%
-46
- C4 -
-
1MUN
7
MUTY_ECOLI
A:
[1-225]
M
Q
A
S
Q
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
--
T
LH
G
--
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
---
I
L
N
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.98
55%
-52
- C4 -
-
1KG2
4
MUTY_ECOLI
A:
[6-224]
-----
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
--
G
--
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
---
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
--------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.97
55%
-48
- C4 -
-
1KG5
5
MUTY_ECOLI
A:
[6-225]
-----
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
--
G
--
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
---
I
L
D
G
N
V
Q
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.48
55%
-44
- C4 -
-
1WEG
4
MUTY_ECOLI
A:
[6-225]
-----
F
S
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
T
L
P
W
Q
I
D
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
--
G
--
G
K
F
P
E
T
F
E
E
V
A
A
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
---
I
L
D
G
N
V
A
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
A
L
Y
P
G
K
K
P
K
-------------------------------------------------------------------------------------------------------------------------------------------