@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQ05: (2017-11-24 )
MVQQIDAPLREDVRLLGNLLGETLKQHAGQELFNQIEQIRALAKGARDGQAEAEKQLEQLFLELPDEELLPLTRAFSHFLNFANIAEQYHVVRSRRQAEFDPDANSPNPLVHLFKKFKDKNISTEKLFQQICDLKIELVLTAHPTEVSRRTLIQKYDDINACLSQLDQQKLTPRERQNALANLKKQISSAWQTDEIRQHRPTPVDEAKWGFATIEQTLWNAVPKFIRELNELVQDNCQQNLPLHIAPVRFASWMGGDRDGNPNVTHQITQEVLWLSRWQAADLYLRDIENLRWELSIQSCSEEMVQAIGSPHPEPYREYLRATRERLKATRHWLAQRLQGLEADDSNVIKSKDELLQPLLLCYRSLIDSNLPEIANGQLLDFIYRVNCFGIELLKLDIRQESGRHRQAISAITEYLGLGNFDSWTEQARQNFLIQELQSKRPLLPKYINEPEGSLIGHPDVQEVFATMRTLADQPPESLGAYIISMAEYPSDVLAVLLLQKEAGIQHPLRVVPLFETLKDLDGAATTMNTLFNMHWYKQHIQGKHEVMIGYSDSAKDAGFMSANWAQYRAQEELTAIARKHGVQLTLFHGRGGSISRGGAPTQQALFSQPPGSISGAIRVTEQGEMIRFKFGLEGIAMQNLEIYTAATLEATLLPPPEPKAEWRELMNRMTDHSVKVYRQTVRENPHFVKYLRTVTPELELQMLPLGSRPAKRKVSGGIESLRAIPWVFAWTQIRLMLPAWLGTGAAINEVIADQQKATLDEMLQQWPYFQTLIDMLEMVLSKADANIALYYESHLTEDEDLKVLGNQLRQRLKDAVETLLALKDESKLLSDNEVLDQSMQVRKPYLLPLHLLQAELMKRRRDYLAERQAEHTPVDHALMVSIAGIAAGLRNTG
Atome Classification :
(20 SA)
.........10........20........30........40........-50....--....60--.........70........80........90.....-----...100..-------.....--..110.....-..120........130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230...-....-240.......250.......260.......270.......280.......290.......300-----....-...------------------..310-----------...-....----..320.......330---........340-.------------------..--.....350.......360.......370.......380.......390.......400.......410.......420........-430.......440.......450.......460.......470.--------......480.......490.......500.--------..---....510.......520.......530.......540.......550.......560--.......570.......580.......590.......-600........610.......620.......630....--...640.......650....--...660.......670.......----680.......690.......700.......710...-----------------------....720.----------------------------......730......---.740.......750....--.--.--.760.......770.......780.......790.......800........810...---....820....---...830.......840.......850.......860.--------------....---------..---------870..-.....880.......890..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MVQQIDA
P
L
R
E
D
V
R
L
L
G
N
L
L
G
E
T
L
K
Q
H
A
G
Q
E
L
F
N
Q
I
E
Q
I
R
A
L
AKGARDG-
Q
A
E
A
E
K
--
Q
L
E
Q
L
---
F
L
EL
P
D
E
E
L
L
P
L
T
R
A
F
S
H
F
L
N
F
A
N
I
A
E
Q
Y
H
V
V
R
S
R
R
-----QAEF--DP-------DANSP--
N
P
L
V
H
L
F
K
K
F-KDK-NI
S
T
E
K
L
F
Q
Q
I
CD
L
K
I
E
L
V
L
TAHPT
E
V
S
R
R
T
L
I
Q
KY
D
D
I
N
A
C
L
S
Q
L
D
Q
QKL
T
P
R
E
R
Q
N
A
L
A
N
L
K
K
Q
I
S
SAWQT
D
E
I
RQHRPTPVDEAK
W
G
F
A
T
I
E
Q
T
L
W
N
A
V
P
K
F
I
R
E
L
N
E
L
V
Q
D
-
N
C
QQ-NLP
L
H
I
APV
R
F
A
S
WMGGDRDGNP
N
V
T
H
Q
I
T
Q
E
V
L
W
L
S
RW
Q
A
A
D
L
Y
L
R
D
IEN
L
R
W
E
L
S
I
Q
S
C
-------
S
E
E
M
-
V
Q
A
------------------IGS-------------PH
P
-
E
P
Y
R
----
E
Y
L
R
A
T
R
E
R
L
K
A
T
R
----
H
W
L
A
Q
R
L
QGL--E------------------AD--D
S
N
VI
K
S
K
D
E
L
L
Q
P
L
L
L
C
Y
R
S
L
I
DSN
L
P
E
IANG
Q
L
L
D
F
I
Y
RVNCF
G
I
E
L
L
K
L
D
IRQESGR
H
R
Q
A
I
S
A
I
T
E
Y
LGLGN-
F
D
S
W
T
E
Q
A
R
-
Q
N
F
L
I
Q
E
L
Q
SKRPL
L
P
K
Y
INEPEGSLIGHP
D
V
Q
E
V
F
A
T
M
R
T
L
AD--------Q
P
P
E
S
L
G
A
Y
I
I
S
M
A
EY
P
S
D
V
L
A
V
L
L
L
Q
K
EA--------GI---QHP
L
R
VV
P
L
F
E
T
L
K
D
LDG
A
A
T
T
M
N
T
L
F
N
M
H
W
Y
K
Q
H
IQGK
H
E
V
M
I
GYSDSAKDAGFMS--A
N
W
A
Q
Y
R
A
Q
E
E
L
T
A
I
A
R
KHG
V
Q
L
T
L
F
HGRGGSISRGG-AP-
T
Q
Q
A
L
FSQPPGSIS
G
A
I
R
V
TEQG
E
M
I
R
F
K
FGLEG
I
--
A
M
Q
N
L
E
I
Y
T
A
A
T
L
E
A
TLLPP--PEP
K
A
E
W
R
E
L
M
N
R
MTD
H
S
V
K
V
Y
R
----
Q
T
V
RENP
H
F
V
K
Y
L
R
T
VTP
E
L
E
L
Q
M
LPLGSRP
A
K
R
K
V-----------------------SG
G
I
E
S
L
R
----------------------------AI
P
W
V
F
A
W
T
Q
I
R
L
M
L
---
P
A
WLGT
G
A
A
I
N
E
V
I
AD
Q
Q
--
K
--
A
--
T
L
D
E
M
L
Q
QW
P
Y
F
Q
T
L
I
D
M
L
E
M
V
L
SKADA
N
I
A
L
Y
YESHLTE
D
E
-
D
L
K
V
L
G
N
Q
L
R
Q
R
L
K
D
---
A
V
E
T
L
L
ALK
D
E
---
S
K
LLSD
N
E
V
L
D
Q
S
M
QVRK
P
Y
L
L
P
L
H
L
L
Q
A
E
L
M
K
R
R
R
D
--------------
Y
L
A
E
---------
R
Q---------AEHTP-V
D
H
A
L
M
V
S
I
A
G
I
A
A
GLRNTG
2
PsiBlast_PDB
84.94
50%
-5
- C3 -
-
1JQN
2
CAPP_ECOLI
A:
[4-883]
---
Q
Y
S
A
-
L
R
S
N
V
S
M
L
G
K
V
L
G
E
T
I
K
D
A
L
G
E
H
I
L
E
R
V
E
T
I
R
K
L
S
K
S
S
R
A
G
-
N
D
A
N
R
Q
--
E
L
L
T
T
---
L
Q
N
L
S
N
D
E
L
L
P
V
A
R
A
F
S
Q
F
L
N
L
A
N
T
A
E
Q
Y
H
S
I
S
P
K
G
-----
E
A
--------------
A
S
N
P
--
E
V
I
A
R
T
L
R
K
L
-
K
N
Q
P
E
L
S
E
D
T
I
K
K
A
V
E
S
L
S
L
E
L
V
L
T
A
H
P
T
E
I
T
R
R
T
L
I
H
K
M
V
E
V
N
A
C
L
K
Q
L
D
N
K
D
I
A
D
Y
E
H
N
Q
L
M
R
R
L
R
Q
L
I
A
Q
S
W
H
T
D
E
I
R
K
L
R
P
S
P
V
D
E
A
K
W
G
F
A
V
V
E
N
S
L
W
Q
G
V
P
N
Y
L
R
E
L
N
E
Q
L
E
E
-
N
L
G
Y
-
K
L
P
V
E
F
V
P
V
R
F
T
S
W
M
G
G
D
R
D
G
N
P
N
V
T
A
D
I
T
R
H
V
L
L
L
S
R
W
K
A
T
D
L
F
L
K
D
I
Q
V
L
V
S
E
L
S
M
V
E
A
-------
T
P
E
L
-
L
A
L
------------------
V
G
E
-------------
E
G
A
A
E
P
Y
R
----
Y
L
M
K
N
L
R
S
R
L
M
A
T
Q
----
A
W
L
E
A
R
L
K
G
E
--
E
L-----------------
P
K
--
P
E
G
L
L
T
Q
N
E
E
L
W
E
P
L
Y
A
C
Y
Q
S
L
Q
A
C
G
M
G
I
I
A
N
G
D
L
L
D
T
L
R
R
V
K
C
F
G
V
P
L
V
R
I
D
I
R
Q
E
S
T
R
H
T
E
A
L
G
E
L
T
R
Y
L
G
I
G
D
-
Y
E
S
W
S
E
A
D
K
-
Q
A
F
L
I
R
E
L
N
S
K
R
P
L
L
P
R
N
W
-
Q
P
S
A
------
E
T
R
E
V
L
D
T
C
Q
V
I
A
E
--------
A
P
Q
G
S
I
A
A
Y
V
I
S
M
A
K
T
P
S
D
V
L
A
V
H
L
L
L
K
E
A
--------
G
I
---
G
F
A
M
P
V
A
P
L
F
E
T
L
D
D
L
N
N
A
N
D
V
M
T
Q
L
L
N
I
D
W
Y
R
G
L
I
Q
G
K
Q
M
V
M
I
G
Y
S
D
S
A
K
D
A
G
V
M
A
--
A
S
W
A
Q
Y
Q
A
Q
D
A
L
I
K
T
C
E
K
A
G
I
E
L
T
L
F
H
G
R
G
G
S
I
G
R
G
G
-
A
P
-
A
H
A
A
L
L
S
Q
P
P
G
S
L
K
G
G
L
R
V
T
E
Q
G
E
M
I
R
F
K
Y
G
L
P
E
I
--
T
V
S
S
L
S
L
Y
T
G
A
I
L
E
A
N
L
L
P
P
--
P
E
P
K
E
S
W
R
R
I
M
D
E
L
S
V
I
S
C
D
V
Y
R
----
G
Y
V
R
E
N
K
D
F
V
P
Y
F
R
S
A
T
P
E
Q
E
L
G
K
L
P
L
G
S
R
P
-----------------------------
G
G
V
E
S
L
R
----------------------------
A
I
P
W
I
F
A
W
T
Q
N
R
L
M
L
---
P
A
W
L
G
A
G
T
A
L
Q
K
V
V
E
D
G
K
--
Q
--
S
--
E
L
E
A
M
C
R
D
W
P
F
F
S
T
R
L
G
M
L
E
M
V
F
A
K
A
D
L
W
L
A
E
Y
Y
D
Q
R
L
V
-
D
K
-
A
L
W
P
L
G
K
E
L
R
N
L
Q
E
E
---
D
I
K
V
V
L
A
I
A
N
D
---
S
H
L
M
A
D
L
P
W
I
A
E
S
I
Q
L
R
N
I
Y
T
D
P
L
N
V
L
Q
A
E
L
L
H
R
S
R
Q
--------------
A
E
K
E
---------
G
Q
---------
E
P
D
P
R
-
V
E
Q
A
L
M
V
T
I
A
G
I
A
A
G
M
R
N
T
G
3
PsiBlast_PDB
84.58
50%
-7
- C3 -
-
1FIY
1
CAPP_ECOLI
A:
[4-883]
---
Q
Y
S
A
-
L
R
S
N
V
S
M
L
G
K
V
L
G
E
T
I
K
D
A
L
G
E
H
I
L
E
R
V
E
T
I
R
K
L
S
K
S
S
R
A
G
-
N
D
A
N
R
Q
--
E
L
L
T
T
---
L
Q
N
L
S
N
D
E
L
L
P
V
A
R
A
F
S
Q
F
L
N
L
A
N
T
A
E
Q
Y
H
S
I
S
P
K
G
-----
E
A
--------------
A
S
N
P
--
E
V
I
A
R
T
L
R
K
L
-
K
N
Q
P
E
L
S
E
D
T
I
K
K
A
V
E
S
L
S
L
E
L
V
L
T
A
H
P
T
E
I
T
R
R
T
L
I
H
K
M
V
E
V
N
A
C
L
K
Q
L
D
N
K
D
I
A
D
Y
E
H
N
Q
L
M
R
R
L
R
Q
L
I
A
Q
S
W
H
T
D
E
I
R
K
L
R
P
S
P
V
D
E
A
K
W
G
F
A
V
V
E
N
S
L
W
Q
G
V
P
N
Y
L
R
E
L
N
E
Q
L
E
E
-
N
L
G
Y
-
K
L
P
V
E
F
V
P
V
R
F
T
S
W
M
G
G
D
R
D
G
N
P
N
V
T
A
D
I
T
R
H
V
L
L
L
S
R
W
K
A
T
D
L
F
L
K
D
I
Q
V
L
V
S
E
L
S
M
V
E
A
-------
T
P
E
L
-
L
A
L
------------------
V
G
E
-------------
E
G
A
A
E
P
Y
R
----
Y
L
M
K
N
L
R
S
R
L
M
A
T
Q
----
A
W
L
E
A
R
L
K
G
E
--
E
L-----------------
P
K
--
P
E
G
L
L
T
Q
N
E
E
L
W
E
P
L
Y
A
C
Y
Q
S
L
Q
A
C
G
M
G
I
I
A
N
G
D
L
L
D
T
L
R
R
V
K
C
F
G
V
P
L
V
R
I
D
I
R
Q
E
S
T
R
H
T
E
A
L
G
E
L
T
R
Y
L
G
I
G
D
-
Y
E
S
W
S
E
A
D
K
-
Q
A
F
L
I
R
E
L
N
S
K
R
P
L
L
P
R
N
W
-
Q
P
S
A
------
E
T
R
E
V
L
D
T
C
Q
V
I
A
E
--------
A
P
Q
G
S
I
A
A
Y
V
I
S
M
A
K
T
P
S
D
V
L
A
V
H
L
L
L
K
E
A
--------
G
I
---
G
F
A
M
P
V
A
P
L
F
E
T
L
D
D
L
N
N
A
N
D
V
M
T
Q
L
L
N
I
D
W
Y
R
G
L
I
Q
G
K
Q
M
V
M
I
G
Y
S
D
S
A
K
D
A
G
V
M
A
--
A
S
W
A
Q
Y
Q
A
Q
D
A
L
I
K
T
C
E
K
A
G
I
E
L
T
L
F
H
G
R
G
G
S
I
G
R
G
G
-
A
P
-
A
H
A
A
L
L
S
Q
P
P
G
S
L
K
G
G
L
R
V
T
E
Q
G
E
M
I
R
F
K
Y
G
L
P
E
I
--
T
V
S
S
L
S
L
Y
T
G
A
I
L
E
A
N
L
L
P
P
--
P
E
P
K
E
S
W
R
R
I
M
D
E
L
S
V
I
S
C
D
V
Y
R
----
G
Y
V
R
E
N
K
D
F
V
P
Y
F
R
S
A
T
P
E
Q
E
L
G
K
L
P
L
G
S
R
P
A
------------------------------
V
E
S
L
R
----------------------------
A
I
P
W
I
F
A
W
T
Q
N
R
L
M
L
---
P
A
W
L
G
A
G
T
A
L
Q
K
V
V
E
D
G
K
--
Q
--
S
--
E
L
E
A
M
C
R
D
W
P
F
F
S
T
R
L
G
M
L
E
M
V
F
A
K
A
D
L
W
L
A
E
Y
Y
D
Q
R
L
V
-
D
K
-
A
L
W
P
L
G
K
E
L
R
N
L
Q
E
E
---
D
I
K
V
V
L
A
I
A
N
D
---
S
H
L
M
A
D
L
P
W
I
A
E
S
I
Q
L
R
N
I
Y
T
D
P
L
N
V
L
Q
A
E
L
L
H
R
S
R
Q
--------------
A
E
K
E
---------
G
Q
---------
E
P
D
P
R
-
V
E
Q
A
L
M
V
T
I
A
G
I
A
A
G
M
R
N
T
G
1
PsiBlast_PDB
84.56
50%
-5
- C3 -
-
1QB4
1
CAPP_ECOLI
A:
[4-883]
---
Q
Y
S
A
-
L
R
S
N
V
S
M
L
G
K
V
L
G
E
T
I
K
D
A
L
G
E
H
I
L
E
R
V
E
T
I
R
K
L
S
K
S
S
R
A
G
-
N
D
A
N
R
Q
--
E
L
L
T
T
---
L
Q
N
L
S
N
D
E
L
L
P
V
A
R
A
F
S
Q
F
L
N
L
A
N
T
A
E
Q
Y
H
S
I
S
P
K
G
-----
E
A
--------------
A
S
N
P
--
E
V
I
A
R
T
L
R
K
L
-
K
N
Q
P
E
L
S
E
D
T
I
K
K
A
V
E
S
L
S
L
E
L
V
L
T
A
H
P
T
E
I
T
R
R
T
L
I
H
K
M
V
E
V
N
A
C
L
K
Q
L
D
N
K
D
I
A
D
Y
E
H
N
Q
L
M
R
R
L
R
Q
L
I
A
Q
S
W
H
T
D
E
I
R
K
L
R
P
S
P
V
D
E
A
K
W
G
F
A
V
V
E
N
S
L
W
Q
G
V
P
N
Y
L
R
E
L
N
E
Q
L
E
E
-
N
L
G
Y
-
K
L
P
V
E
F
V
P
V
R
F
T
S
W
M
G
G
D
R
D
G
N
P
N
V
T
A
D
I
T
R
H
V
L
L
L
S
R
W
K
A
T
D
L
F
L
K
D
I
Q
V
L
V
S
E
L
S
M
V
E
A
-------
T
P
E
L
-
L
A
L
------------------
V
G
E
-------------
E
G
A
A
E
P
Y
R
----
Y
L
M
K
N
L
R
S
R
L
M
A
T
Q
----
A
W
L
E
A
R
L
K
G
E
--
E
L
-----------------
P
K
--
P
E
G
L
L
T
Q
N
E
E
L
W
E
P
L
Y
A
C
Y
Q
S
L
Q
A
C
G
M
G
I
I
A
N
G
D
L
L
D
T
L
R
R
V
K
C
F
G
V
P
L
V
R
I
D
I
R
Q
E
S
T
R
H
T
E
A
L
G
E
L
T
R
Y
L
G
I
G
D
-
Y
E
S
W
S
E
A
D
K
-
Q
A
F
L
I
R
E
L
N
S
K
R
P
L
L
P
R
N
W
-
Q
P
S
A
------
E
T
R
E
V
L
D
T
C
Q
V
I
A
E
--------
A
P
Q
G
S
I
A
A
Y
V
I
S
M
A
K
T
P
S
D
V
L
A
V
H
L
L
L
K
E
A
--------
G
I
---
G
F
A
M
P
V
A
P
L
F
E
T
L
D
D
L
N
N
A
N
D
V
M
T
Q
L
L
N
I
D
W
Y
R
G
L
I
Q
G
K
Q
M
V
M
I
G
Y
S
D
S
A
K
D
A
G
V
M
A
--
A
S
W
A
Q
Y
Q
A
Q
D
A
L
I
K
T
C
E
K
A
G
I
E
L
T
L
F
H
G
R
G
G
S
I
G
R
G
G
-
A
P
-
A
H
A
A
L
L
S
Q
P
P
G
S
L
K
G
G
L
R
V
T
E
Q
G
E
M
I
R
F
K
Y
G
L
P
E
I
--
T
V
S
S
L
S
L
Y
T
G
A
I
L
E
A
N
L
L
P
P
--
P
E
P
K
E
S
W
R
R
I
M
D
E
L
S
V
I
S
C
D
V
Y
R
----
G
Y
V
R
E
N
K
D
F
V
P
Y
F
R
S
A
T
P
E
Q
E
L
G
K
L
P
L
G
S
R
P
A
------------------------------
V
E
S
L
R
----------------------------
A
I
P
W
I
F
A
W
T
Q
N
R
L
M
L
---
P
A
W
L
G
A
G
T
A
L
Q
K
V
V
E
D
G
K
--
Q
--
S
--
E
L
E
A
M
C
R
D
W
P
F
F
S
T
R
L
G
M
L
E
M
V
F
A
K
A
D
L
W
L
A
E
Y
Y
D
Q
R
L
V
-
D
K
-
A
L
W
P
L
G
K
E
L
R
N
L
Q
E
E
---
D
I
K
V
V
L
A
I
A
N
D
---
S
H
L
M
A
D
L
P
W
I
A
E
S
I
Q
L
R
N
I
Y
T
D
P
L
N
V
L
Q
A
E
L
L
H
R
S
R
Q
--------------
A
E
K
E
---------
G
Q
---------
E
P
D
P
R
-
V
E
Q
A
L
M
V
T
I
A
G
I
A
A
G
M
R
N
T
G
35
HHSearch
82.76
50%
10
- C3 -
-
1JQN
2
CAPP_ECOLI
A:
[4-883]
----
Q
Y
S
A
L
R
S
N
V
S
M
L
G
K
V
L
G
E
T
I
K
D
A
L
G
E
H
I
L
E
R
V
E
T
I
R
K
L
S
K
S
S
R
A
G
-
N
D
A
N
R
Q
--
E
L
L
T
T
---
L
Q
N
L
S
N
D
E
L
L
P
V
A
R
A
F
S
Q
F
L
N
L
A
N
T
A
E
Q
Y
H
S
I
S
P
K
G
-----
E
--------------
A
A
S
N
P
--
E
V
I
A
R
T
L
R
K
L
-
K
N
Q
P
E
L
S
E
D
T
I
K
K
A
V
E
S
L
S
L
E
L
V
L
T
A
H
P
T
E
I
T
R
R
T
L
I
H
K
M
V
E
V
N
A
C
L
K
Q
L
D
N
K
D
I
A
D
Y
E
H
N
Q
L
M
R
R
L
R
Q
L
I
A
Q
S
W
H
T
D
E
I
R
K
L
R
P
S
P
V
D
E
A
K
W
G
F
A
V
V
E
N
S
L
W
Q
G
V
P
N
Y
L
R
E
L
N
E
Q
L
E
E
-
N
L
G
Y
-
K
L
P
V
E
F
V
P
V
R
F
T
S
W
M
G
G
D
R
D
G
N
P
N
V
T
A
D
I
T
R
H
V
L
L
L
S
R
W
K
A
T
D
L
F
L
K
D
I
Q
V
L
V
S
E
L
S
M
V
-----------
E
A
-
T
P
E
------------------
L
L
A
L
------------
V
G
E
---------------
E
G
A
A
E
P
Y
R
----
Y
L
M
K
N
L
R
S
R
L
--
M
A
T
Q
A
W
L
E
A
R
L
K
GEEL---
P
K
--
P
E
G
L
L
T
Q
N
E
E
L
W
E
P
L
Y
A
C
Y
Q
S
L
Q
A
C
G
M
G
I
I
A
N
G
D
L
L
D
T
L
R
R
V
K
C
F
G
V
P
L
V
R
I
D
I
R
Q
E
S
T
R
H
T
E
A
L
G
E
L
T
R
Y
L
G
I
G
D
-
Y
E
S
W
S
E
A
D
K
-
Q
A
F
L
I
R
E
L
N
S
K
R
P
L
L
P
R
N
W
Q
P
S
A
E
T
-------
R
E
V
L
D
T
C
Q
V
I
A
E
--------
A
P
Q
G
S
I
A
A
Y
V
I
S
M
A
K
T
P
S
D
V
L
A
V
H
L
L
L
K
E
A
--------
G
I
---
G
F
A
M
P
V
A
P
L
F
E
T
L
D
D
L
N
N
A
N
D
V
M
T
Q
L
L
N
I
D
W
Y
R
G
L
I
Q
G
K
Q
M
V
M
I
G
Y
S
D
S
A
K
D
A
G
V
M
A
--
A
S
W
A
Q
Y
Q
A
Q
D
A
L
I
K
T
C
E
K
A
G
I
E
L
T
L
F
H
G
R
G
G
S
I
G
R
G
G
-
A
P
-
A
H
A
A
L
L
S
Q
P
P
G
S
L
K
G
G
L
R
V
T
E
Q
G
E
M
I
R
F
K
Y
G
L
P
E
I
--
T
V
S
S
L
S
L
Y
T
G
A
I
L
E
A
N
L
L
P
P
--
P
E
P
K
E
S
W
R
R
I
M
D
E
L
S
V
I
S
C
D
V
Y
R
----
G
Y
V
R
E
N
K
D
F
V
P
Y
F
R
S
A
T
P
E
Q
E
L
G
K
L
P
L
G
S
R
P
-----------------------------
G
G
V
E
S
L
R
----------------------------
A
I
P
W
I
F
A
W
T
Q
N
R
L
M
L
---
P
A
W
L
G
A
G
T
A
L
Q
K
V
V
E
D
G
K
--
Q
--
S
--
E
L
E
A
M
C
R
D
W
P
F
F
S
T
R
L
G
M
L
E
M
V
F
A
K
A
D
L
W
L
A
E
Y
Y
D
Q
R
L
V
-
D
K
-
A
L
W
P
L
G
K
E
L
R
N
L
Q
E
E
---
D
I
K
V
V
L
A
I
A
N
D
---
S
H
L
M
A
D
L
P
W
I
A
E
S
I
Q
L
R
N
I
Y
T
D
P
L
N
V
L
Q
A
E
L
L
H
R
S
R
Q
--------------
A
E
K
E
---------
G
Q
---------
E
P
D
P
R
-
V
E
Q
A
L
M
V
T
I
A
G
I
A
A
G
M
R
N
T
G
36
HHSearch
82.25
50%
6
- C3 -
-
1QB4
1
CAPP_ECOLI
A:
[4-883]
----
Q
Y
S
A
L
R
S
N
V
S
M
L
G
K
V
L
G
E
T
I
K
D
A
L
G
E
H
I
L
E
R
V
E
T
I
R
K
L
S
K
S
S
R
A
G
-
N
D
A
N
R
Q
--
E
L
L
T
T
---
L
Q
N
L
S
N
D
E
L
L
P
V
A
R
A
F
S
Q
F
L
N
L
A
N
T
A
E
Q
Y
H
S
I
S
P
K
G
-----
E
--------------
A
A
S
N
P
--
E
V
I
A
R
T
L
R
K
L
-
K
N
Q
P
E
L
S
E
D
T
I
K
K
A
V
E
S
L
S
L
E
L
V
L
T
A
H
P
T
E
I
T
R
R
T
L
I
H
K
M
V
E
V
N
A
C
L
K
Q
L
D
N
K
D
I
A
D
Y
E
H
N
Q
L
M
R
R
L
R
Q
L
I
A
Q
S
W
H
T
D
E
I
R
K
L
R
P
S
P
V
D
E
A
K
W
G
F
A
V
V
E
N
S
L
W
Q
G
V
P
N
Y
L
R
E
L
N
E
Q
L
E
E
-
N
L
G
Y
-
K
L
P
V
E
F
V
P
V
R
F
T
S
W
M
G
G
D
R
D
G
N
P
N
V
T
A
D
I
T
R
H
V
L
L
L
S
R
W
K
A
T
D
L
F
L
K
D
I
Q
V
L
V
S
E
L
S
M
V
-----------
E
A
-
T
P
E
------------------
L
L
A
L
------------
V
G
E
---------------
E
G
A
A
E
P
Y
R
----
Y
L
M
K
N
L
R
S
R
L
--
M
A
T
Q
A
W
L
E
A
R
L
K
G
E
E
L
---
P
K
--
P
E
G
L
L
T
Q
N
E
E
L
W
E
P
L
Y
A
C
Y
Q
S
L
Q
A
C
G
M
G
I
I
A
N
G
D
L
L
D
T
L
R
R
V
K
C
F
G
V
P
L
V
R
I
D
I
R
Q
E
S
T
R
H
T
E
A
L
G
E
L
T
R
Y
L
G
I
G
D
-
Y
E
S
W
S
E
A
D
K
-
Q
A
F
L
I
R
E
L
N
S
K
R
P
L
L
P
R
N
W
Q
P
S
A
E
T
-------
R
E
V
L
D
T
C
Q
V
I
A
E
--------
A
P
Q
G
S
I
A
A
Y
V
I
S
M
A
K
T
P
S
D
V
L
A
V
H
L
L
L
K
E
A
--------
G
I
---
G
F
A
M
P
V
A
P
L
F
E
T
L
D
D
L
N
N
A
N
D
V
M
T
Q
L
L
N
I
D
W
Y
R
G
L
I
Q
G
K
Q
M
V
M
I
G
Y
S
D
S
A
K
D
A
G
V
M
A
--
A
S
W
A
Q
Y
Q
A
Q
D
A
L
I
K
T
C
E
K
A
G
I
E
L
T
L
F
H
G
R
G
G
S
I
G
R
G
G
-
A
P
-
A
H
A
A
L
L
S
Q
P
P
G
S
L
K
G
G
L
R
V
T
E
Q
G
E
M
I
R
F
K
Y
G
L
P
E
I
--
T
V
S
S
L
S
L
Y
T
G
A
I
L
E
A
N
L
L
P
P
--
P
E
P
K
E
S
W
R
R
I
M
D
E
L
S
V
I
S
C
D
V
Y
R
----
G
Y
V
R
E
N
K
D
F
V
P
Y
F
R
S
A
T
P
E
Q
E
L
G
K
L
P
L
G
S
R
P
A
------------------------------
V
E
S
L
R
----------------------------
A
I
P
W
I
F
A
W
T
Q
N
R
L
M
L
---
P
A
W
L
G
A
G
T
A
L
Q
K
V
V
E
D
G
K
--
Q
--
S
--
E
L
E
A
M
C
R
D
W
P
F
F
S
T
R
L
G
M
L
E
M
V
F
A
K
A
D
L
W
L
A
E
Y
Y
D
Q
R
L
V
-
D
K
-
A
L
W
P
L
G
K
E
L
R
N
L
Q
E
E
---
D
I
K
V
V
L
A
I
A
N
D
---
S
H
L
M
A
D
L
P
W
I
A
E
S
I
Q
L
R
N
I
Y
T
D
P
L
N
V
L
Q
A
E
L
L
H
R
S
R
Q
--------------
A
E
K
E
---------
G
Q
---------
E
P
D
P
R
-
V
E
Q
A
L
M
V
T
I
A
G
I
A
A
G
M
R
N
T
G
7
PsiBlast_PDB
76.89
39%
30
- C3 -
-
5FDN
1
CAPP3_ARATH
A:
[43-987]
-
V
S
E
D
D
K
L
V
E
Y
D
A
L
L
L
D
R
F
L
-
D
I
L
Q
D
L
H
G
E
D
L
R
E
T
V
Q
E
L
Y
E
L
S
-
A
E
Y
E
G
-
K
R
E
P
S
K
L
E
E
L
G
S
V
---
L
T
S
L
D
P
G
D
S
I
V
I
S
K
A
F
S
H
M
L
N
L
A
N
L
A
E
E
V
Q
I
A
H
R
R
R
IKKLK
K
G
D
F
V
D
E
S
-------
S
A
T
T
E
--
S
D
I
E
E
T
F
K
R
L
V
S
D
L
-
G
K
S
P
E
E
I
F
D
A
L
K
N
Q
T
V
D
L
V
L
T
A
H
P
T
Q
S
V
R
R
S
L
L
Q
K
H
G
R
I
R
D
C
L
A
Q
L
Y
A
K
D
I
T
P
D
D
K
Q
E
L
D
E
S
L
Q
R
E
I
Q
A
A
F
R
T
D
E
I
R
R
T
P
P
T
P
Q
D
E
M
R
A
G
M
S
Y
F
H
E
T
I
W
K
G
V
P
K
F
L
R
R
V
D
T
A
L
K
N
I
G
I
D
E
-
R
V
P
Y
N
A
P
L
I
Q
F
S
S
W
M
G
G
D
R
D
G
N
P
R
V
T
P
E
V
T
R
D
V
C
L
L
A
R
M
M
A
A
N
L
Y
Y
N
Q
I
E
N
L
M
F
E
L
S
M
W
R
C
-------
T
D
E
F
R
V
R
A
D
E
L
H
RNAKHYIEFW----
K
T
I
-------------
P
P
T
-
E
P
Y
R
----
V
I
L
G
D
V
R
D
K
L
Y
H
T
R
----
E
R
S
R
Q
L
L
S
N
G
--
I
------------------
S
D
IP
E
E
A
T
F
T
N
V
E
Q
F
L
E
P
L
E
L
C
Y
R
S
L
C
S
C
G
D
S
P
I
A
D
G
S
L
L
D
F
L
R
Q
V
S
T
F
G
L
S
L
V
R
L
D
I
R
Q
E
S
E
R
H
T
D
V
L
D
A
I
T
K
H
L
D
I
G
S
S
Y
R
D
W
S
E
E
G
R
-
Q
E
W
L
L
A
E
L
S
G
K
R
P
L
F
G
P
D
L
P
K
T
E
-------
E
I
S
D
V
L
D
T
F
K
V
I
S
E
--------
L
P
S
D
C
F
G
A
Y
I
I
S
M
A
T
S
P
S
D
V
L
A
V
E
L
L
Q
R
E
C
--------
H
V
---
K
N
P
L
R
V
V
P
L
F
E
K
L
A
D
L
E
A
A
P
A
A
V
A
R
L
F
S
I
D
W
Y
K
N
R
I
N
G
K
Q
E
V
M
I
G
Y
S
D
S
G
K
D
A
G
R
L
S
--
A
A
W
E
L
Y
K
A
Q
E
E
L
V
K
V
A
K
K
Y
G
V
K
L
T
M
F
H
G
R
G
G
T
V
G
R
G
G
-
G
P
-
T
H
L
A
I
L
S
Q
P
P
D
T
V
N
G
S
L
R
V
T
V
Q
G
E
V
I
E
Q
S
F
G
E
A
H
L
--
C
F
R
T
L
Q
R
F
T
A
A
T
L
E
H
G
M
N
P
P
--
I
S
P
K
P
E
W
R
A
L
L
D
E
M
A
V
V
A
T
E
E
Y
R
----
S
V
V
F
Q
E
P
R
F
V
E
Y
F
R
L
A
T
P
E
L
E
Y
G
R
M
-----------------------------------
G
G
I
E
S
L
R
----------------------------
A
I
P
W
I
F
A
W
T
Q
T
R
F
H
L
---
P
V
W
L
G
F
G
A
A
F
R
Y
A
I
K
K
D
V
--
R
--
N
L
H
M
L
Q
D
M
Y
K
Q
W
P
F
F
R
V
T
I
D
L
I
E
M
V
F
A
K
G
D
P
G
I
A
A
L
Y
D
K
L
L
V
S
-
E
-
D
L
W
A
F
G
E
K
L
R
A
N
F
D
E
---
T
K
N
L
V
L
Q
T
A
G
H
---
K
D
L
L
E
G
D
P
Y
L
K
Q
R
L
R
L
R
D
S
Y
I
T
T
L
N
V
C
Q
A
Y
T
L
K
R
I
R
D
AN
Y
N
V
T
L
R
P-----
H
I
S
K
-------------------------G
L
E
D
T
L
I
L
T
M
K
G
I
A
A
G
L
Q
N
T
G
24
PsiBlast_CBE
76.57
39%
28
- C3 -
-
5FDN
1
CAPP3_ARATH
B:
[43-987]
-
V
S
E
D
D
K
L
V
E
Y
D
A
L
L
L
D
R
F
L
-
D
I
L
Q
D
L
H
G
E
D
L
R
E
T
V
Q
E
L
Y
E
L
S
-
A
E
Y
E
G
-
K
R
E
P
S
K
L
E
E
L
G
S
V
---
L
T
S
L
D
P
G
D
S
I
V
I
S
K
A
F
S
H
M
L
N
L
A
N
L
A
E
E
V
Q
I
A
H
R
R
R
IKKLK
K
G
D
F
V
D
E
S
-------
S
A
T
T
E
--
S
D
I
E
E
T
F
K
R
L
V
S
D
L
-
G
K
S
P
E
E
I
F
D
A
L
K
N
Q
T
V
D
L
V
L
T
A
H
P
T
Q
S
V
R
R
S
L
L
Q
K
H
G
R
I
R
D
C
L
A
Q
L
Y
A
K
D
I
T
P
D
D
K
Q
E
L
D
E
S
L
Q
R
E
I
Q
A
A
F
R
---------
T
P
Q
D
E
M
R
A
G
M
S
Y
F
H
E
T
I
W
K
G
V
P
K
F
L
R
R
V
D
T
A
L
K
N
I
G
I
D
E
-
R
V
P
Y
N
A
P
L
I
Q
F
S
S
W
M
G
G
D
R
D
G
N
P
R
V
T
P
E
V
T
R
D
V
C
L
L
A
R
M
M
A
A
N
L
Y
Y
N
Q
I
E
N
L
M
F
E
L
S
M
W
R
C
-------
T
D
E
F
R
V
R
A
D
E
LIEFW-----------
K
T
I
-------------
P
P
T
-
E
P
Y
R
----
V
I
L
G
D
V
R
D
K
L
Y
H
T
R
----
E
R
S
R
Q
L
L
S
N
G
--
I
------------------
S
D
IP
E
E
A
T
F
T
N
V
E
Q
F
L
E
P
L
E
L
C
Y
R
S
L
C
S
C
G
D
S
P
I
A
D
G
S
L
L
D
F
L
R
Q
V
S
T
F
G
L
S
L
V
R
L
D
I
R
Q
E
S
E
R
H
T
D
V
L
D
A
I
T
K
H
L
D
I
G
S
S
Y
R
D
W
S
E
E
G
R
-
Q
E
W
L
L
A
E
L
S
G
K
R
P
L
F
G
P
D
L
P
K
T
E
-------
E
I
S
D
V
L
D
T
F
K
V
I
S
E
--------
L
P
S
D
C
F
G
A
Y
I
I
S
M
A
T
S
P
S
D
V
L
A
V
E
L
L
Q
R
E
C
--------
H
V
---
K
N
P
L
R
V
V
P
L
F
E
K
L
A
D
L
E
A
A
P
A
A
V
A
R
L
F
S
I
D
W
Y
K
N
R
I
N
G
K
Q
E
V
M
I
G
Y
S
D
S
G
K
D
A
G
R
L
S
--
A
A
W
E
L
Y
K
A
Q
E
E
L
V
K
V
A
K
K
Y
G
V
K
L
T
M
F
H
G
R
G
G
T
V
G
R
G
G
-
G
P
-
T
H
L
A
I
L
S
Q
P
P
D
T
V
N
G
S
L
R
V
T
V
Q
G
E
V
I
E
Q
S
F
G
E
A
H
L
--
C
F
R
T
L
Q
R
F
T
A
A
T
L
E
H
G
M
N
P
P
--
I
S
P
K
P
E
W
R
A
L
L
D
E
M
A
V
V
A
T
E
E
Y
R
----
S
V
V
F
Q
E
P
R
F
V
E
Y
F
R
L
A
T
P
E
L
E
Y
G
R
M
N
I
-----------------------------------
I
E
S
L
R
----------------------------
A
I
P
W
I
F
A
W
T
Q
T
R
F
H
L
---
P
V
W
L
G
F
G
A
A
F
R
Y
A
I
K
K
D
V
--
R
--
N
L
H
M
L
Q
D
M
Y
K
Q
W
P
F
F
R
V
T
I
D
L
I
E
M
V
F
A
K
G
D
P
G
I
A
A
L
Y
D
K
L
L
V
S
-
E
-
D
L
W
A
F
G
E
K
L
R
A
N
F
D
E
---
T
K
N
L
V
L
Q
T
A
G
H
---
K
D
L
L
E
G
D
P
Y
L
K
Q
R
L
R
L
R
D
S
Y
I
T
T
L
N
V
C
Q
A
Y
T
L
K
R
I
R
D
AN
Y
N
V
T
L
R
P-----
H
I
S
K
-------------------------G
L
E
D
T
L
I
L
T
M
K
G
I
A
A
G
L
Q
N
T
G
5
PsiBlast_PDB
76.51
40%
34
- C3 -
-
4BXH
2
CAPPA_FLATR
A:
[48-990]
-
V
S
E
D
D
K
L
V
E
Y
D
A
L
L
L
D
K
F
L
-
D
I
L
Q
D
L
H
G
E
D
L
K
E
A
V
Q
Q
C
Y
E
L
S
-
A
E
Y
E
G
-
K
H
D
P
K
K
L
E
E
L
G
S
L
---
L
T
S
L
D
T
G
D
S
I
V
I
A
K
A
F
S
H
M
L
N
L
A
N
L
A
E
E
L
Q
I
A
Y
R
R
R
IKLK-
S
G
D
F
--
A
D
-------
E
A
N
A
T
T
E
S
D
I
E
E
T
F
K
R
L
-
V
H
K
L
N
K
S
P
E
E
V
F
D
A
L
K
N
Q
T
V
E
L
V
L
T
A
H
P
T
Q
S
V
R
R
S
L
L
Q
K
H
G
R
I
R
N
C
L
A
Q
L
Y
A
K
D
I
T
P
D
D
K
Q
E
L
D
E
A
L
H
R
E
I
Q
A
A
F
R
T
D
E
I
R
-
T
P
P
T
P
Q
D
E
M
R
A
G
M
S
Y
F
H
E
T
I
W
K
G
V
P
K
F
L
R
R
V
D
T
A
L
K
N
I
G
I
N
E
-
R
F
P
Y
N
A
P
L
I
Q
F
S
S
W
M
G
G
D
R
D
G
N
P
R
V
T
P
E
V
T
R
D
V
C
L
L
A
R
M
M
T
S
N
M
Y
F
S
Q
I
E
D
L
M
I
E
M
S
M
W
R
C
-------
N
S
E
L
R
V
R
A
E
E
L
Y
R
T
ARKDVKHYIEFW
K
R
I
-------------
P
P
N
-
Q
P
Y
R
----
V
I
L
G
D
V
R
D
K
L
Y
N
T
R
----
E
R
S
R
H
L
L
V
D
G
--
K
------------------
S
D
IP
D
E
A
V
Y
T
N
V
E
Q
L
L
E
P
L
E
L
C
Y
R
S
L
C
D
C
G
D
H
V
I
A
D
G
S
L
L
D
F
L
R
Q
V
S
T
F
G
L
S
L
V
K
L
D
I
R
Q
E
S
D
R
H
T
E
V
L
D
A
I
T
Q
H
L
G
I
G
S
-
Y
R
E
W
S
E
E
K
R
-
Q
E
W
L
L
A
E
L
S
G
K
R
P
L
I
G
P
D
L
P
K
T
E
-------
E
V
K
D
C
L
D
T
F
K
V
L
A
E
--------
L
P
S
D
C
F
G
A
Y
I
I
S
M
A
T
S
T
S
D
V
L
A
V
E
L
L
Q
R
E
Y
--------
H
I
---
K
H
P
L
R
V
V
P
L
F
E
K
L
A
D
L
E
A
A
P
A
A
M
T
R
L
F
S
M
D
W
Y
R
N
R
I
D
G
K
Q
E
V
M
I
G
Y
S
D
S
G
K
D
A
G
R
F
S
--
A
A
W
Q
L
Y
K
T
Q
E
Q
I
V
K
I
A
K
E
F
G
V
K
L
V
I
F
H
G
R
G
G
T
V
G
R
G
G
-
G
P
-
T
H
L
A
L
L
S
Q
P
P
D
T
I
N
G
S
L
R
V
T
V
Q
G
E
V
I
E
Q
S
F
G
E
E
H
L
--
C
F
R
T
L
Q
R
F
C
A
A
T
L
E
H
G
M
N
P
P
--
I
S
P
R
P
E
W
R
E
L
M
D
Q
M
A
V
V
A
T
E
E
Y
R
----
S
V
V
F
K
E
P
R
F
V
E
Y
F
R
L
A
T
P
E
L
E
F
G
R
M
N
---
R
P
S
K
---------------------------
G
G
I
E
S
L
R
----------------------------
A
I
P
W
I
F
S
W
T
Q
T
R
F
H
L
---
P
V
W
L
G
F
G
A
A
F
K
H
A
I
Q
K
D
S
--
K
N
L
Q
--
M
L
Q
E
M
Y
K
T
W
P
F
F
R
V
T
I
D
L
V
E
M
V
F
A
K
G
N
P
G
I
A
A
L
N
D
K
L
L
V
S
-
E
-
D
L
R
P
F
G
E
S
L
R
A
N
Y
E
E
---
T
K
N
Y
L
L
K
I
A
G
H
---
K
D
L
L
E
G
D
P
Y
L
K
Q
G
I
R
L
R
D
P
Y
I
T
T
L
N
V
C
Q
A
Y
T
L
K
R
I
R
D
PNYHVTLRPHISKE
Y
----------------------------G
L
E
D
T
L
I
L
T
M
K
G
I
A
A
G
M
Q
N
T
G
4
PsiBlast_PDB
76.38
40%
28
- C3 -
-
3ZGE
2
CAPPA_FLATR
A:
[48-990]
-
V
S
E
D
D
K
L
V
E
Y
D
A
L
L
L
D
K
F
L
-
D
I
L
Q
D
L
H
G
E
D
L
K
E
A
V
Q
Q
C
Y
E
L
S
-
A
E
Y
E
G
-
K
H
D
P
K
K
L
E
E
L
G
S
L
---
L
T
S
L
D
T
G
D
S
I
V
I
A
K
A
F
S
H
M
L
N
L
A
N
L
A
E
E
L
Q
I
A
Y
R
R
R
IKLK-
S
G
D
F
--
A
D
-------
E
A
N
A
T
TE
S
D
I
E
E
T
F
K
R
L
-
V
H
K
L
N
K
S
P
E
E
V
F
D
A
L
K
N
Q
T
V
E
L
V
L
T
A
H
P
T
Q
S
V
R
R
S
L
L
Q
K
H
G
R
I
R
N
C
L
A
Q
L
Y
A
-
D
I
T
P
D
D
K
Q
E
L
D
E
A
L
H
R
E
I
Q
A
A
F
R
T
D
E
I
R
R
T
P
P
T
P
Q
D
E
M
R
A
G
M
S
Y
F
H
E
T
I
W
K
G
V
P
K
F
L
R
R
V
D
T
A
L
K
N
I
G
I
N
E
-
R
F
P
Y
N
A
P
L
I
Q
F
S
S
W
M
G
G
D
R
D
G
N
P
R
V
T
P
E
V
T
R
D
V
C
L
L
A
R
M
M
T
S
N
M
Y
F
S
Q
I
E
D
L
M
I
E
M
S
M
W
R
C
-------
N
S
E
L
R
V
R
A
E
E
L
Y
R
THYIEFW------
K
R
I
-------------
P
P
N
-
Q
P
Y
R
----
V
I
L
G
D
V
R
D
K
L
Y
N
T
R
----
E
R
S
R
H
L
L
V
D
G
--
K
------------------
S
D
IP
D
E
A
V
Y
T
N
V
E
Q
L
L
E
P
L
E
L
C
Y
R
S
L
C
D
C
G
D
H
V
I
A
D
G
S
L
L
D
F
L
R
Q
V
S
T
F
G
L
S
L
V
K
L
D
I
R
Q
E
S
D
R
H
T
E
V
L
D
A
I
T
Q
H
L
G
I
G
S
-
Y
R
E
W
S
E
E
K
R
-
Q
E
W
L
L
A
E
L
S
G
K
R
P
L
I
G
P
D
L
P
K
T
E
-------
E
V
K
D
C
L
D
T
F
K
V
L
A
E
--------
L
P
S
D
C
F
G
A
Y
I
I
S
M
A
T
S
T
S
D
V
L
A
V
E
L
L
Q
R
E
Y
--------
H
I
---
K
H
P
L
R
V
V
P
L
F
E
K
L
A
D
L
E
A
A
P
A
A
M
T
R
L
F
S
M
D
W
Y
R
N
R
I
D
G
K
Q
E
V
M
I
G
Y
S
D
S
G
K
D
A
G
R
F
S
--
A
A
W
Q
L
Y
K
T
Q
E
Q
I
V
K
I
A
K
E
F
G
V
K
L
V
I
F
H
G
R
G
G
T
V
G
R
G
G
-
G
P
-
T
H
L
A
L
L
S
Q
P
P
D
T
I
N
G
S
L
R
V
T
V
Q
G
E
V
I
E
Q
S
F
G
E
E
H
L
--
C
F
R
T
L
Q
R
F
C
A
A
T
L
E
H
G
M
N
P
P
--
I
S
P
R
P
E
W
R
E
L
M
D
Q
M
A
V
V
A
T
E
E
Y
R
----
S
V
V
F
K
E
P
R
F
V
E
Y
F
R
L
A
T
P
E
L
E
F
G
R
------------------------------------
G
G
I
E
S
L
R
----------------------------
A
I
P
W
I
F
S
W
T
Q
T
R
F
H
L
---
P
V
W
L
G
F
G
A
A
F
K
H
A
I
Q
K
D
S
--
K
N
L
Q
--
M
L
Q
E
M
Y
K
T
W
P
F
F
R
V
T
I
D
L
V
E
M
V
F
A
K
G
N
P
G
I
A
A
L
N
D
K
L
L
V
S
-
E
-
D
L
R
P
F
G
E
S
L
R
A
N
Y
E
E
---
T
K
N
Y
L
L
K
I
A
G
H
---
K
D
L
L
E
G
D
P
Y
L
K
Q
G
I
R
L
R
D
P
Y
I
T
T
L
N
V
C
Q
A
Y
T
L
K
R
I
R
D
PNYHVTLRPHISKE-----------------------------G
L
E
D
T
L
I
L
T
M
K
G
I
A
A
G
M
Q
N
T
G
6
PsiBlast_PDB
76.36
41%
20
- C3 -
-
3ZGB
2
CAPP1_FLAPR
A:
[50-972]
--------------
I
L
Q
D
L
H
G
E
D
L
K
E
-
A
V
Q
E
C
Y
----
E
L
S
A
E
Y
E
G
K
H
D
------
P
K
--
K
L
E
E
L
G
S
V
L
T
S
L
D
P
G
D
S
I
V
I
A
K
A
F
S
H
M
L
N
L
A
N
L
A
E
E
V
Q
I
A
Y
R
R
R
IKLK-
R
G
D
F
--
A
D
-------
E
A
N
A
T
TE
S
D
I
E
E
T
F
K
K
L
-
V
L
K
L
N
K
S
P
E
E
V
F
D
A
L
K
N
Q
T
V
D
L
V
L
T
A
H
P
T
Q
S
V
R
R
S
L
L
Q
K
H
G
R
I
R
N
C
L
A
Q
L
Y
A
K
D
I
T
P
D
D
K
Q
E
L
D
E
A
L
H
R
E
I
Q
A
A
F
R
T
D
E
I
R
R
T
P
P
T
P
Q
D
E
M
R
A
G
M
S
Y
F
H
E
T
I
W
K
G
V
P
K
F
L
R
R
V
D
T
A
L
K
N
I
G
I
N
E
-
R
V
P
Y
N
A
P
L
I
Q
F
S
S
W
M
G
G
D
R
D
G
N
P
R
V
T
P
E
V
T
R
D
V
C
L
L
A
R
M
M
A
S
N
M
Y
F
S
Q
I
E
D
L
M
F
E
M
S
M
W
R
C
-------
N
S
E
L
R
V
R
A
E
E
L
Y
R
T-------------
Q
V
-------------
P
P
T
-
E
P
Y
R
----
V
I
L
G
D
V
R
D
K
L
Y
N
T
R
E
R
S
R
H
L
L
A
H
G
I
S
D
I
PE
E
------------------
A
V
--
Y
T
N
V
----
E
Q
F
L
E
P
L
E
L
C
Y
R
S
L
C
D
C
G
D
R
V
I
A
D
G
S
L
L
D
F
L
R
Q
V
S
T
F
G
L
S
L
V
K
L
D
I
R
Q
E
S
D
R
H
T
D
V
L
D
A
I
T
Q
H
L
E
I
G
S
-
Y
R
E
W
S
E
E
K
R
-
Q
E
W
L
L
A
E
L
S
G
K
R
P
L
F
G
S
D
L
P
K
T
E
-------
E
V
K
D
V
L
D
T
F
N
V
L
A
E
--------
L
P
S
D
C
F
G
A
Y
I
I
S
M
A
T
S
P
S
D
V
L
A
V
E
L
L
Q
R
E
C
--------
H
V
---
K
H
P
L
R
V
V
P
L
F
E
K
L
A
D
L
E
A
A
P
A
A
M
A
R
L
F
S
I
D
W
Y
R
N
R
I
D
G
K
Q
E
V
M
I
G
Y
S
D
S
G
K
D
A
G
R
F
S
--
A
A
W
Q
L
Y
K
A
Q
E
E
I
I
K
V
A
K
E
F
G
V
K
L
V
I
F
H
G
R
G
G
T
V
G
R
G
G
-
G
P
-
T
H
L
A
I
L
S
Q
P
P
D
T
I
H
G
S
L
R
V
T
V
Q
G
E
V
I
E
Q
S
F
G
E
E
H
L
--
C
F
R
T
L
Q
R
F
C
A
A
T
L
E
H
G
M
N
P
P
--
I
S
P
R
P
E
W
R
E
L
M
D
Q
M
A
V
V
A
T
E
E
Y
R
----
S
I
V
F
K
E
P
R
F
V
E
Y
F
R
L
A
T
P
E
L
E
Y
G
R
M
N
I
G
S
R
P
S
K
---------------------------
G
G
I
E
S
L
R
----------------------------
A
I
P
W
I
F
A
W
T
Q
T
R
F
H
L
---
P
V
W
L
G
F
G
A
A
F
K
H
A
I
K
K
D
S
--
K
N
L
Q
--
M
L
Q
E
M
Y
K
T
W
P
F
F
R
V
T
I
D
L
V
E
M
V
F
A
K
G
D
P
G
I
A
A
L
N
D
K
L
L
V
S
-
E
-
D
L
W
P
F
G
E
S
L
R
A
N
Y
E
E
---
T
K
D
Y
L
L
K
I
A
G
H
---
R
D
L
L
E
G
D
P
Y
L
K
Q
R
I
R
L
R
D
S
Y
I
T
T
L
N
V
C
Q
A
Y
T
L
K
R
I
R
D
PNYHVTLRPHISK------------------------------G
L
E
D
T
L
I
L
T
M
K
G
I
A
A
G
M
Q
N
T
G
38
HHSearch
75.38
40%
17
- C3 -
-
5FDN
1
CAPP3_ARATH
A:
[43-987]
--
V
S
E
D
D
K
L
V
E
Y
D
A
L
L
L
D
R
F
L
D
I
L
Q
D
L
H
G
E
D
L
R
E
T
V
Q
E
L
Y
E
L
S
A
E
Y
E
G
K
R
E
P
S
K
L
E
--
E
L
G
S
V
---
L
T
S
L
D
P
G
D
S
I
V
I
S
K
A
F
S
H
M
L
N
L
A
N
L
A
E
E
V
Q
I
A
H
R
R
R
-----
I
K
K
L
--
K
K
GD
F
V
D
E
S
S
A
T
T
E
--
S
D
I
E
E
T
F
K
R
L
-
V
S
D
L
G
K
S
P
E
E
I
F
D
A
L
K
N
Q
T
V
D
L
V
L
T
A
H
P
T
Q
S
V
R
R
S
L
L
Q
K
H
G
R
I
R
D
C
L
A
Q
L
Y
A
K
D
I
T
P
D
D
K
Q
E
L
D
E
S
L
Q
R
E
I
Q
A
A
F
R
T
D
E
I
R
R
T
P
P
T
P
Q
D
E
M
R
A
G
M
S
Y
F
H
E
T
I
W
K
G
V
P
K
F
L
R
R
V
D
T
A
L
K
N
-
I
G
I
D
E
R
V
P
Y
N
A
P
L
I
Q
F
S
S
W
M
G
G
D
R
D
G
N
P
R
V
T
P
E
V
T
R
D
V
C
L
L
A
R
M
M
A
A
N
L
Y
Y
N
Q
I
E
N
L
M
F
E
L
S
M
W
R
C
-------
T
D
E
F
-
R
V
R
------------------
A
D
E
L
------------
H
R
N
-----AKHY
I
E
F
W
K
T
I
P
P
T
E
P
Y
R
----
V
I
L
G
D
V
R
D
K
L
--
Y
H
T
R
E
R
S
R
Q
L
L
S
NGISDIP
E
---
E
-
A
T
F
T
N
V
E
Q
F
L
E
P
L
E
L
C
Y
R
S
L
C
S
C
G
D
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P
I
A
D
G
S
L
L
D
F
L
R
Q
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T
F
G
L
S
L
V
R
L
D
I
R
Q
E
S
E
R
H
T
D
V
L
D
A
I
T
K
H
L
D
I
G
S
-
S
Y
R
D
W
S
E
E
G
R
Q
E
W
L
L
A
E
L
S
G
K
R
P
L
F
G
P
D
L
P
K
T
E
E
I
-------
S
D
V
L
D
T
F
K
V
I
S
E
--------
L
P
S
D
C
F
G
A
Y
I
I
S
M
A
T
S
P
S
D
V
L
A
V
E
L
L
Q
R
E
C
--------
H
V
---
K
N
P
L
R
V
V
P
L
F
E
K
L
A
D
L
E
A
A
P
A
A
V
A
R
L
F
S
I
D
W
Y
K
N
R
I
N
G
K
Q
E
V
M
I
G
Y
S
D
S
G
K
D
A
G
R
L
S
--
A
A
W
E
L
Y
K
A
Q
E
E
L
V
K
V
A
K
K
Y
G
V
K
L
T
M
F
H
G
R
G
G
T
V
G
R
G
G
-
G
P
-
T
H
L
A
I
L
S
Q
P
P
D
T
V
N
G
S
L
R
V
T
V
Q
G
E
V
I
E
Q
S
F
G
E
A
H
L
--
C
F
R
T
L
Q
R
F
T
A
A
T
L
E
H
G
M
N
P
P
--
I
S
P
K
P
E
W
R
A
L
L
D
E
M
A
V
V
A
T
E
E
Y
R
----
S
V
V
F
Q
E
P
R
F
V
E
Y
F
R
L
A
T
P
E
L
E
Y
G
R
M
-----------------------------------
G
G
I
E
S
L
R
----------------------------
A
I
P
W
I
F
A
W
T
Q
T
R
F
H
L
---
P
V
W
L
G
F
G
A
A
F
R
Y
A
I
K
K
D
V
R
N
L
--
H
--
M
L
Q
D
M
Y
K
Q
W
P
F
F
R
V
T
I
D
L
I
E
M
V
F
A
K
G
D
P
G
I
A
A
L
Y
D
-
K
L
L
-
V
S
E
D
L
W
A
F
G
E
K
L
R
A
N
F
D
E
---
T
K
N
L
V
L
Q
T
A
G
H
---
K
D
L
L
E
G
D
P
Y
L
K
Q
R
L
R
L
R
D
S
Y
I
T
T
L
N
V
C
Q
A
Y
T
L
K
R
I
R
D
--------------
A
N
Y
N
V
T
L
R
PHISK---------------
G
-
L
E
D
T
L
I
L
T
M
K
G
I
A
A
G
L
Q
N
T
G
23
PsiBlast_CBE
75.09
41%
28
- C3 -
-
3ZGB
2
CAPP1_FLAPR
B:
[50-972]
--------------
I
L
Q
D
L
H
G
E
D
L
K
E
-
A
V
Q
E
C
Y
----
E
L
S
A
E
Y
E
G
K
H
D
------
P
K
--
K
L
E
E
L
G
S
V
L
T
S
L
D
P
G
D
S
I
V
I
A
K
A
F
S
H
M
L
N
L
A
N
L
A
E
E
V
Q
I
A
Y
R
R
R
IKLK-
R
G
D
F
--
A
D
-------
E
A
N
A
T
TE
S
D
I
E
E
T
F
K
K
L
-
V
L
K
L
N
K
S
P
E
E
V
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A
L
K
N
Q
T
V
D
L
V
L
T
A
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P
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Q
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R
R
S
L
L
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H
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R
I
R
N
C
L
A
Q
L
Y
A
K
D
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D
D
K
Q
E
L
D
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A
L
H
R
E
I
Q
A
A
F
R
T
D
E
I
R
-
T
P
P
T
P
Q
D
E
M
R
A
G
M
S
Y
F
H
E
T
I
W
K
G
V
P
K
F
L
R
R
V
D
T
A
L
K
N
I
G
I
N
E
-
R
V
P
Y
N
A
P
L
I
Q
F
S
S
W
M
G
G
D
R
D
G
N
P
R
V
T
P
E
V
T
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V
C
L
L
A
R
M
M
A
S
N
M
Y
F
S
Q
I
E
D
L
M
F
E
M
S
M
W
R
C
-------
N
S
E
L
R
V
R
A
E
E
L
Y
R
T
AR-----------
Q
V
-------------
P
P
T
-
E
P
Y
R
----
V
I
L
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D
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D
K
L
Y
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T
R
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L
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G
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D
I
PE
E
------------------
A
V
--
Y
T
N
V
----
E
Q
F
L
E
P
L
E
L
C
Y
R
S
L
C
D
C
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D
R
V
I
A
D
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S
L
L
D
F
L
R
Q
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S
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G
L
S
L
V
K
L
D
I
R
Q
E
S
D
R
H
T
D
V
L
D
A
I
T
Q
H
L
E
I
G
S
-
Y
R
E
W
S
E
E
K
R
-
Q
E
W
L
L
A
E
L
S
G
K
R
P
L
F
G
S
D
L
P
K
T
E
-------
E
V
K
D
V
L
D
T
F
N
V
L
A
E
--------
L
P
S
D
C
F
G
A
Y
I
I
S
M
A
T
S
P
S
D
V
L
A
V
E
L
L
Q
R
E
C
--------
H
V
---
K
H
P
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V
V
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L
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K
L
A
D
L
E
A
A
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A
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A
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L
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S
I
D
W
Y
R
N
R
I
D
G
K
Q
E
V
M
I
G
Y
S
D
S
G
K
D
A
G
R
F
S
--
A
A
W
Q
L
Y
K
A
Q
E
E
I
I
K
V
A
K
E
F
G
V
K
L
V
I
F
H
G
R
G
G
T
V
G
R
G
G
-
G
P
-
T
H
L
A
I
L
S
Q
P
P
D
T
I
H
G
S
L
R
V
T
V
Q
G
E
V
I
E
Q
S
F
G
E
E
H
L
--
C
F
R
T
L
Q
R
F
C
A
A
T
L
E
H
G
M
N
P
P
--
I
S
P
R
P
E
W
R
E
L
M
D
Q
M
A
V
V
A
T
E
E
Y
R
----
S
I
V
F
K
E
P
R
F
V
E
Y
F
R
L
A
T
P
E
L
E
Y
G
R
M
N
I
G
S
R
P
S
K
----------------------------
G
I
E
S
L
R
----------------------------
A
I
P
W
I
F
A
W
T
Q
T
R
F
H
L
---
P
V
W
L
G
F
G
A
A
F
K
H
A
I
K
K
D
S
--
K
N
L
Q
--
M
L
Q
E
M
Y
K
T
W
P
F
F
R
V
T
I
D
L
V
E
M
V
F
A
K
G
D
P
G
I
A
A
L
N
D
K
L
L
V
S
-
E
-
D
L
W
P
F
G
E
S
L
R
A
N
Y
E
E
---
T
K
D
Y
L
L
K
I
A
G
H
---
R
D
L
L
E
G
D
P
Y
L
K
Q
R
I
R
L
R
D
S
Y
I
T
T
L
N
V
C
Q
A
Y
T
L
K
R
I
R
D
PN
Y
H
V
T
L
R
PHIS-------------------------------G
L
E
D
T
L
I
L
T
M
K
G
I
A
A
G
M
Q
N
T
G
22
PsiBlast_CBE
73.82
41%
23
- C3 -
-
5VYJ
2
?
C:
[104-970]
-----------------------------------------------------------------------------------
H
M
L
N
L
A
N
L
A
E
E
V
Q
I
A
H
R
R
R
-----
N
S
K
----------------
E
--
S
D
I
E
E
T
L
K
R
L
V
S
E
V
-
G
K
S
P
E
E
V
F
E
A
L
K
N
Q
T
V
D
L
V
F
T
A
H
P
T
Q
S
A
R
R
S
L
L
Q
K
N
A
R
I
R
N
C
L
T
Q
L
N
A
K
D
I
T
D
D
D
K
Q
E
L
D
E
A
L
Q
R
E
I
Q
A
A
F
R
T
D
E
I
R
R
A
Q
P
T
P
Q
D
E
M
R
Y
G
M
S
Y
I
H
E
T
V
W
K
G
V
P
K
F
L
R
R
V
D
T
A
L
K
N
I
G
I
N
E
-
R
L
P
Y
N
V
S
L
I
R
F
S
S
W
M
G
G
D
R
D
G
N
P
R
V
T
P
E
V
T
R
D
V
C
L
L
A
R
M
M
A
A
N
L
Y
I
D
Q
I
E
E
L
M
F
E
L
S
M
W
R
C
NDELRVR
A
E
E
L
-
H
S
S
------------------
S
G
S
KVTKYYIEFWKQI
P
P
N
-
E
P
Y
R
----
V
I
L
G
H
V
R
D
K
L
Y
N
T
R
ERAR
H
L
L
A
S
G
V
S
E
I
--
S
------------------
A
E
--
S
S
--
F
T
S
I
E
E
F
L
E
P
L
E
L
C
Y
K
S
L
C
D
C
G
D
K
A
I
A
D
G
S
L
L
D
L
L
R
Q
V
F
T
F
G
L
S
L
V
K
L
D
I
R
Q
E
S
E
R
H
T
D
V
I
D
A
I
T
T
H
L
G
I
G
S
-
Y
R
E
W
S
E
D
K
R
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Q
E
W
L
L
S
E
L
R
G
K
R
P
L
L
P
P
D
L
P
Q
T
E
-------
E
I
A
D
V
I
G
A
F
H
V
L
A
E
--------
L
P
P
D
S
F
G
P
Y
I
I
S
M
A
T
A
P
S
D
V
L
A
V
E
L
L
Q
R
E
C
--------
G
V
---
R
Q
P
L
P
V
V
P
L
F
E
R
L
A
D
L
Q
S
A
P
A
S
V
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R
L
F
S
V
D
W
Y
M
D
R
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K
G
K
Q
Q
V
M
V
G
Y
S
D
S
G
K
D
A
G
R
L
S
--
A
A
W
Q
L
Y
R
A
Q
E
E
M
A
Q
V
A
K
R
Y
G
V
K
L
T
L
F
H
G
R
G
G
T
V
G
R
G
G
-
G
P
-
T
H
L
A
I
L
S
Q
P
P
D
T
I
N
G
S
I
R
V
T
V
Q
G
E
V
I
E
F
C
F
G
E
E
H
L
--
C
F
Q
T
L
Q
R
F
T
A
A
T
L
E
H
G
M
H
P
P
--
V
S
P
K
P
E
W
R
K
L
M
D
E
M
A
V
V
A
T
E
E
Y
R
----
S
V
V
V
K
E
A
R
F
V
E
Y
F
R
S
A
T
P
E
T
E
Y
G
R
M
N
I
G
S
R
P
A
K
R
R
P
-----------------------
G
G
G
I
T
T
L
R
----------------------------
A
I
P
W
I
F
S
W
T
Q
T
R
F
H
L
---
P
V
W
L
G
V
G
A
A
F
K
F
A
I
D
K
D
V
--
R
NF
Q
--
V
L
K
E
M
Y
N
E
W
P
F
F
R
V
T
L
D
L
L
E
M
V
F
A
K
G
D
P
G
I
A
G
L
Y
D
E
L
L
V
A
E
E
--
L
K
P
F
G
K
Q
L
R
D
K
Y
V
E
---
T
Q
Q
L
L
L
Q
I
A
G
H
---
K
D
I
L
E
G
D
P
F
L
K
Q
G
L
V
L
R
N
P
Y
I
T
T
L
N
V
F
Q
A
Y
T
L
K
R
I
R
D
PNFKVTPQPPLSKE
F
A
D
E
-----------AGLVKLNPA
S
E
Y
P
P
G
L
E
D
T
L
I
L
T
M
K
G
I
A
A
G
M
Q
N
T
G
21
PsiBlast_CBE
73.25
41%
24
- C3 -
-
5VYJ
2
?
D:
[104-970]
-----------------------------------------------------------------------------------
H
M
L
N
L
A
N
L
A
E
E
V
Q
I
A
H
R
R
R
-----
N
S
K
L
------------------
S
D
I
E
E
T
L
K
R
L
V
S
E
V
-
G
K
S
P
E
E
V
F
E
A
L
K
N
Q
T
V
D
L
V
F
T
A
H
P
T
Q
S
A
R
R
S
L
L
Q
K
N
A
R
I
R
N
C
L
T
Q
L
N
A
K
D
I
T
D
D
D
K
Q
E
L
D
E
A
L
Q
R
E
I
Q
A
A
F
R
T
D
E
I
R
R
A
Q
P
T
P
Q
D
E
M
R
Y
G
M
S
Y
I
H
E
T
V
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K
G
V
P
K
F
L
R
R
V
D
T
A
L
K
N
I
G
I
N
E
-
R
L
P
Y
N
V
S
L
I
R
F
S
S
W
M
G
G
D
R
D
G
N
P
R
V
T
P
E
V
T
R
D
V
C
L
L
A
R
M
M
A
A
N
L
Y
I
D
Q
I
E
E
L
M
F
E
L
S
M
W
R
C
NDELRVR
A
E
E
L
-
H
S
S
------------------
S
G
S
KVTKYYIEFWKQI
P
P
N
-
E
P
Y
R
----
V
I
L
G
H
V
R
D
K
L
Y
N
T
R
ERAR
H
L
L
A
S
G
V
S
E
I
--
S
------------------
A
E
--
S
S
--
F
T
S
I
E
E
F
L
E
P
L
E
L
C
Y
K
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C
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A
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A
D
G
S
L
L
D
L
L
R
Q
V
F
T
F
G
L
S
L
V
K
L
D
I
R
Q
E
S
E
R
H
T
D
V
I
D
A
I
T
T
H
L
G
I
G
S
-
Y
R
E
W
S
E
D
K
R
-
Q
E
W
L
L
S
E
L
R
G
K
R
P
L
L
P
P
D
L
P
Q
T
E
-------
E
I
A
D
V
I
G
A
F
H
V
L
A
E
--------
L
P
P
D
S
F
G
P
Y
I
I
S
M
A
T
A
P
S
D
V
L
A
V
E
L
L
Q
R
E
C
--------
G
V
---
R
Q
P
L
P
V
V
P
L
F
E
R
L
A
D
L
Q
S
A
P
A
S
V
E
R
L
F
S
V
D
W
Y
M
D
R
I
K
G
K
Q
Q
V
M
V
G
Y
S
D
S
G
K
D
A
G
R
L
S
--
A
A
W
Q
L
Y
R
A
Q
E
E
M
A
Q
V
A
K
R
Y
G
V
K
L
T
L
F
H
G
R
G
G
T
V
G
R
G
G
-
G
P
-
T
H
L
A
I
L
S
Q
P
P
D
T
I
N
G
S
I
R
V
T
V
Q
G
E
V
I
E
F
C
F
G
E
E
H
L
--
C
F
Q
T
L
Q
R
F
T
A
A
T
L
E
H
G
M
H
P
P
--
V
S
P
K
P
E
W
R
K
L
M
D
E
M
A
V
V
A
T
E
E
Y
R
----
S
V
V
V
K
E
A
R
F
V
E
Y
F
R
S
A
T
P
E
T
E
Y
G
R
M
N
I
G
S
R
P
A
K
R
R
P
-----------------------
G
G
G
I
T
T
L
R
----------------------------
A
I
P
W
I
F
S
W
T
Q
T
R
F
H
L
---
P
V
W
L
G
V
G
A
A
F
K
F
A
I
D
K
D
V
--
R
NF
Q
--
V
L
K
E
M
Y
N
E
W
P
F
F
R
V
T
L
D
L
L
E
M
V
F
A
K
G
D
P
G
I
A
G
L
Y
D
E
L
L
V
A
E
E
--
L
K
P
F
G
K
Q
L
R
D
K
Y
V
E
---
T
Q
Q
L
L
L
Q
I
A
G
H
---
K
D
I
L
E
G
D
P
F
L
K
Q
G
L
V
L
R
N
P
Y
I
T
T
L
N
V
F
Q
A
Y
T
L
K
R
I
R
D
PNFKVTPQPPLSKE
F
A
D
E
-----------AGLVKLNPA
S
E
Y
P
P
G
L
E
D
T
L
I
L
T
M
K
G
I
A
A
G
M
Q
N
T
G
53
HHSearch
43.10
14%
-135
- C3 -
-
3KHD
-
?
B:
[230-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
N
F
I
A
A
S
F
I
Q
S
A
D
D
V
R
L
I
R
N
L
L
G
P
R
--------
G
-----
R
H
I
K
I
I
P
K
I
E
N
I
E
G
I
I
H
F
D
K
I
L
A
E
S
-------------
D
G
I
M
I
A
R
G
D
L
G
M
E
I
S
P
E
------
K
V
F
L
A
Q
K
L
M
I
S
K
C
N
L
Q
G
K
P
I
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
41.46
14%
-131
- C3 -
-
3GR4
3
KPYM_HUMAN
B:
[255-345]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
D
M
V
F
A
S
F
I
R
K
A
S
D
V
H
E
V
R
K
V
L
G
E
K
--------
G
-----
K
N
I
K
I
I
S
K
I
E
N
H
E
G
V
R
R
F
D
E
I
L
E
A
S
-------------
D
G
I
M
V
A
R
G
D
L
G
I
E
I
P
A
E
------
K
V
F
L
A
Q
K
M
M
I
G
R
C
N
R
A
G
K
P
V
I
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
33.84
21%
-5
- C3 -
-
3ODM
-
CAPPA_CLOPE
A:
[179-542]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
V
R
I
I
P
L
V
E
D
V
P
A
L
A
N
I
D
R
I
L
D
E
H
Y
E
I
E
K
S
K
G
H
I
L
K
D
L
R
I
M
I
A
R
S
D
T
A
M
S
Y
G
L
I
S
--
G
V
L
S
V
L
M
A
V
D
G
A
Y
K
W
G
E
K
H
G
V
T
I
S
P
I
L
G
C
G
S
L
P
F
R
G
H
-
F
S
-
E
E
N
--
I
D
E
I
L
A
T
Y
S
G
I
K
T
F
T
F
Q
S
A
L
-
R
Y
D
H
G
E
E
A
T
K
H
A
V
R
E
L
K
E
K
I
A
Q
S
------
K
P
--
R
N
F
S
E
E
D
K
D
L
M
K
E
F
I
G
I
C
S
K
H
Y
L
----
Q
T
------
F
L
K
V
I
D
T
V
S
--
F
V
S
D
F
I
P
-
K
N
R
D
R
L
T
---------------------------------AN
L
D
N
V
A
D
L
VKD
E
V
L
K
Q
E
I
L
S
IDNSK
E
Y
A
V
P
R
A
I
S
F
T
G
A
M
Y
T
L
GMP
P
E
L
M
G
M
G
R
A
L
N
E
I
K
T
K
Y
G
--
Q
--
E
--
G
I
D
K
L
L
E
I
Y
P
-----------
I
L
R
K
D
L
A
F
A
A
R
F
A
N
G
G
V
S
K
-----
K
I
I
D
E
E
A
R
Q
E
Y
K
E
D
M
K
Y
V
N
E
I
L
N
L
G
L
D
---
Y
D
F
L
N
E
N
E
F
Y
H
T
L
L
K
T
T
K
P
I
I
M
H
L
M
G
L
E
E
N
V
M
R
N
S
T
E
--------------
E
L
------------------------------------------------
20
PsiBlast_PDB
33.79
30%
-99
- C2 -
-
1TAU
-
DPO1_THEAQ
A:
[201-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
T
A
R
K
L
L
E
E
W
G
S
L
E
A
L
L
K
N
L
D
--
R
L
K
P
A
I
R
E
K
I
L
A
H
M
-
D
D
L
K
L
S
W
D
L
A
K
V
R
T
D
L
P
L
E
V
D
F
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
33.68
20%
-83
- C3 -
-
1SGJ
-
CITEL_DEIRA
A:
[93-189]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
S
G
V
V
V
P
K
L
E
M
G
A
E
A
R
Q
V
A
Q
M
L
Q
E
R
--------
S
-----
L
P
L
P
I
L
A
G
L
E
T
G
A
G
V
W
N
A
R
E
I
M
E
-
V
---
P
-------
E
V
A
W
A
Y
F
G
A
E
D
Y
T
T
D
L
G
G
K
R
T
P
G
G
L
E
V
L
Y
A
R
S
Q
V
A
L
A
A
R
L
T
G
V
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
32.15
19%
30
- C3 -
-
3ODM
-
CAPPA_CLOPE
B:
[115-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
L
M
S
I
M
S
I
I
E
T
N
V
Q
S
K
E
L
T
G
T
P
A
I
S
E
V
V
V
P
M
I
E
T
G
K
E
I
S
E
F
Q
D
R
V
N
S
V
V
D
M
G
N
K
N
Y
K
T
K
L
D
L
N
S
V
R
I
I
P
L
V
E
D
V
P
A
L
A
N
I
D
R
I
L
D
E
H
Y
E
I
E
K
S
K
G
H
I
L
K
D
L
R
I
M
I
A
R
S
D
T
A
M
S
Y
G
L
I
S
--
G
V
L
S
V
L
M
A
V
D
G
A
Y
K
W
G
E
K
H
G
V
T
I
S
P
I
L
G
C
G
S
L
P
F
R
G
H
F
S
E
E
N
I
D
E
I
L
A
T
Y
S
G
----
I
K
T
F
T
F
Q
S
---
A
L
R
Y
D
H
G
E
E
--
A
T
K
H
A
V
R
E
----
L
K
E
K
I
A
Q
S
KP
R
N
F
S
E
E
D
K
D
L
M
K
E
F
I
G
I
C
S
K
H
Y
L
Q
T
F
L
K
V
I
-
D
T
V
S
F
V
S
D
F
I
P
K
N
-
R
D
R
L
T
--------
N
R
E
V
A
NL
D
N
V
A
D
L
VKD
E
V
L
K
Q
E
I
L
S
IDN
S
K
E
Y
A
V
P
R
----------------------------
A
I
S
F
T
G
A
M
-
Y
T
L
G
M
P
---
P
E
L
M
G
M
G
R
A
L
N
E
I
K
T
K
Y
G
--
Q
--
E
--
G
I
D
K
L
L
E
I
Y
P
I
L
R
------------
K
D
L
A
F
A
A
R
F
A
N
G
G
V
----
S
K
K
I
I
D
E
E
A
R
Q
E
Y
K
E
---
D
M
K
Y
V
N
E
I
L
N
L
GLD
Y
D
F
L
N
E
N
E
F
Y
H
T
L
L
K
T
T
K
P
I
I
M
H
L
M
G
L
E
E
N
V
M
R
N
S
T
E
--------------
E
L
------------------------------------------------