@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQ13: (2017-11-24 )
MSQATSNSSRFNLRAQVVQTLLKVQQGQSLASILNTQLNQVAERDRALFHELVLGTLRQWFALKSISLPLLSKPLNNETVETCLYVGLYQVLCTRIAAHAAISETVDATKQLGFPALSGIVNAILRRATRETDDFQQGLQQAHGLPSWLFKRLKKDWEEQTEALCQSLKQAAPLTLRVNQRHIGRDAYLAKLQSLDIQARACLFSEAGIVLEQSVQITQLLGFEQGWFSVQDEHAQLCATLLPDLNNKTVIDACAAPGGKTAHLLEKFKPAQLIAIDQDPSRLVRVTENLNRLALDQSHTEILAADATKWNPVQPVDCIVLDAPCSATGVIRRHPDIRLLRQSSDIAQTIELQKQILEHMWQQLKVGGTLLYITCSILKSENEQQMINFFTEHPDAKEVKIEADWGIEQVHGRQLLPEAQSGDGFYYCKIQKIT
Atome Classification :
(20 SA)
.........10........20...-..-..---.30........--40.-.......50........60........70...-.--.--..--.80........90...-.....100.--......110.......120.......130-------..---.---....---140...---....150....-.-..-160......-.170.-..-.....180.......190......----------------.200-----------------....--...--.210.-.......220...-----....230...-....240-.......250........260.....-.-.-270...-.....280.......290----.----...-----..---.300.-......310----.--.----.---..----....320....--...330....-...340........350------.......--360.......370.......380.----......390..-----...--..400-----.-.----.----.---.----------.-.---.410----------.-.-.------------...----...-420-.......430..------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSQATSNSSRF
N
L
R
A
Q
V
V
Q
T
L
L
K
V
-QQ-
G
Q
---
S
L
A
S
I
L
N
T
Q
L
N
--
Q
V
A
-
E
R
D
R
A
L
F
H
E
L
V
L
G
T
L
R
Q
W
F
A
L
K
SIS
L
P
L
LSKP-L--N--
N
E
--
T
V
E
T
C
L
Y
V
G
L
Y
Q
V
L
C
T
-
R
I
A
A
H
A
A
I
S
--
E
T
V
D
A
T
K
QLG
F
P
A
L
S
G
I
V
N
A
I
L
R
R
ATRE
T
-------
D
D
---
F
---
Q
Q
G
L
---
Q
Q
AHG
L
---
P
S
W
L
F
K
R
L
K
K
D
-
W
-
E
E
-
Q
T
E
A
L
C
Q
S
L
-
K
Q-AA-
P
L
-
T
L
R
V
N
Q
R
HIG
R
D
A
Y
L
A
K
L
Q
SL
D
I
Q
----------------
A
R
A
------------------
C
L
FS--EA
G
--
I
V
L
-E-QS
V
Q
I
T
Q
L
LGFEQ-----GWFSV
Q
D
E
H
A
-
Q
L
C
A
T
L
L-PDLNN
K
T
V
I
-
D
ACAAPGG
K
T
A
H
L
L
E
K-F-K-P-
A
Q
L
I
-
A
IDQ
D
P
S
R
L
V
R
V
T
E
N
L
N
R
----L----ALD-----QS---H
T
E
I
L
-AADATKW------N--P----V---Q
P
----
V
D
C
I
V
LDAPCS--ATGVIRRHPD-
I
R
L
L
-RQSS
D
I
A
Q
T
I
E
L
------
Q
K
Q
I
L
E
H
--
M
W
Q
Q
L
KVG
G
T
L
L
Y
I
T
C
S
I
LKSE
N
E
----
Q
Q
M
I
N
F
F
TEHP-----DA
K
--
E
V
K
I
------
E
-A----D----W---G----------I-E---QV------------H-G-R------------QLL----PEA-QSG-D
G
F
Y
Y
C
K
I
Q
KIT------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
81.46
40%
3
- C2 -
-
1SQF
-
RSMB_ECOLI
A:
[5-429]
----------
R
N
L
R
S
M
A
A
Q
A
V
E
Q
V
-
V
E
Q
G
Q
---
S
L
S
N
I
L
P
P
L
Q
---
Q
K
V
S
D
K
D
K
A
L
L
Q
E
L
C
F
G
V
L
R
T
L
S
Q
L
D
W
L
I
N
K
L
M
A
R
P
-
M
TG
K
--
Q
R
--
T
V
H
Y
L
I
M
V
G
L
Y
Q
L
L
Y
T
-
R
I
P
P
H
A
A
L
A
--
E
T
V
E
G
A
I
A
I
K
R
P
Q
L
K
G
L
I
N
G
V
L
R
Q
F
Q
R
Q
Q
-------
E
E
---
L
L
A
E
F
N
A
S
---
D
A
R
Y
L
H
---
P
S
W
L
L
K
R
L
Q
K
A
-
Y
P
E
Q
--
W
Q
S
I
V
E
A
N
-
N
Q
-
R
P
-
P
M
-
W
L
R
I
N
R
T
H
H
S
R
D
S
W
L
A
L
L
D
E
A
G
M
K
----------------
G
F
P
------------------
H
A
D
Y
--
P
D
A
--
V
R
L
-
E
-
T
P
A
P
V
H
A
L
P
G
F
E
D
-----
G
W
V
T
V
Q
D
A
S
A
-
Q
G
C
M
T
W
L
A
P
Q
-
N
G
E
H
I
L
-
D
L
C
A
A
P
G
G
K
T
T
H
I
L
E
V
-
A
-
P
-
E
-
A
Q
V
V
-
A
V
D
I
D
E
Q
R
L
S
R
V
Y
D
N
L
K
R
----
L
----
G
M
------
K
A
---
T
--
V
K
-
Q
G
D
G
R
Y
P
------
S
QW
C
----
G
---
E
Q
Q---
F
D
R
I
L
L
D
A
P
C
S
--
A
T
G
V
I
R
R
H
P
D
-
I
K
W
L
-
R
R
D
R
D
I
P
E
L
A
Q
L
------
Q
S
E
I
L
D
A
--
I
W
P
H
L
K
T
G
G
T
L
V
Y
A
T
C
S
V
L
P
E
E
N
S
----
L
Q
I
K
A
F
L
Q
R
T
A
-----
D
A
E
---
L
C
E
------
T
-
G
----
T
----
P
---------------------
E
------------
Q
P
G
-
K
------------
Q
N
L
----
P
G
A
-
E
E
G
-
D
G
F
F
Y
A
K
L
I
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
81.17
40%
18
- C2 -
-
1SQG
-
RSMB_ECOLI
A:
[5-428]
----------
R
N
L
R
S
M
A
A
Q
A
V
E
Q
V
-
V
E
Q
G
Q
---
S
L
S
N
I
L
P
P
L
Q
Q
--
K
V
S
-
D
K
D
K
A
L
L
Q
E
L
C
F
G
V
L
R
T
L
S
Q
L
D
W
L
I
N
K
L
M
A
R
P
-
M
--
T
GK
Q
R
--
T
V
H
Y
L
I
M
V
G
L
Y
Q
L
L
Y
T
-
R
I
P
P
H
A
A
L
A
--
E
T
V
E
G
A
I
A
I
K
R
P
Q
L
K
G
L
I
N
G
V
L
R
Q
F
Q
R
Q
Q
-------
E
E
---
L
---
L
A
E
F
N
A
S
D
A
R
Y
L
H
---
P
S
W
L
L
K
R
L
Q
K
A
-
Y
-
P
E
-
Q
W
Q
S
I
V
E
A
N
-
N
Q
-
R
P
-
P
M
-
W
L
R
I
N
R
T
H
H
S
R
D
S
W
L
A
L
L
D
E
A
G
M
K
----------------
G
F
P
------------------
H
A
D
Y
--
P
D
A
--
V
R
L
-
E
-
T
P
A
P
V
H
A
L
P
G
F
E
D
-----
G
W
V
T
V
Q
D
A
S
A
-
Q
G
C
M
T
W
L
-
A
P
Q
N
G
E
H
I
L
-
D
L
C
A
A
P
G
G
K
T
T
H
I
L
E
V
-
A
-
P
-
E
-
A
Q
V
V
-
A
V
D
I
D
E
Q
R
L
S
R
V
Y
D
N
L
K
R
----
L
----
G
M
K
-----
A
T
---
V
K
Q
G
D
-
G
R
Y
P
S
Q
W
------
C
--
G
----
E
---
Q
Q
----
F
D
R
I
L
L
D
A
P
C
S
--
A
T
G
V
I
R
R
H
P
D
-
I
K
W
L
-
R
R
D
R
D
I
P
E
L
A
Q
L
------
Q
S
E
I
L
D
A
--
I
W
P
H
L
K
T
G
G
T
L
V
Y
A
T
C
S
V
L
P
E
E
N
S
----
L
Q
I
K
A
F
L
Q
R
T
A
-----
D
A
E
--
L
C
E
T
----------------------
G
----------
T
-
P
---
E
Q
------------
P
-
G
-
K
------------
Q
N
L
----
P
G
A
-
E
E
G
-
D
G
F
F
Y
A
K
L
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
81.05
40%
5
- C2 -
-
1SQG
-
RSMB_ECOLI
A:
[5-428]
----------
R
N
L
R
S
M
A
A
Q
A
V
E
Q
V
-
V
E
Q
G
Q
---
S
L
S
N
I
L
P
P
L
Q
---
Q
K
V
S
D
K
D
K
A
L
L
Q
E
L
C
F
G
V
L
R
T
L
S
Q
L
D
W
L
I
N
K
L
M
A
R
P
-
M
TG
K
--
Q
R
--
T
V
H
Y
L
I
M
V
G
L
Y
Q
L
L
Y
T
-
R
I
P
P
H
A
A
L
A
--
E
T
V
E
G
A
I
A
I
K
R
P
Q
L
K
G
L
I
N
G
V
L
R
Q
F
Q
R
Q
Q
-------
E
E
---
L
L
A
E
F
N
A
S
---
D
A
R
Y
L
H
---
P
S
W
L
L
K
R
L
Q
K
A
-
Y
P
E
Q
--
W
Q
S
I
V
E
A
N
-
N
Q
-
R
P
-
P
M
-
W
L
R
I
N
R
T
H
H
S
R
D
S
W
L
A
L
L
D
E
A
G
M
K
----------------
G
F
P
------------------
H
A
D
Y
--
P
D
A
--
V
R
L
-
E
-
T
P
A
P
V
H
A
L
P
G
F
E
D
-----
G
W
V
T
V
Q
D
A
S
A
-
Q
G
C
M
T
W
L
A
P
Q
-
N
G
E
H
I
L
-
D
L
C
A
A
P
G
G
K
T
T
H
I
L
E
V
-
A
-
P
-
E
-
A
Q
V
V
-
A
V
D
I
D
E
Q
R
L
S
R
V
Y
D
N
L
K
R
----
L
----
G
M
------
K
A
---
T
--
V
K
-
Q
G
D
G
R
Y
P
------
S
QW
C
----
G
---
E
Q
Q---
F
D
R
I
L
L
D
A
P
C
S
--
A
T
G
V
I
R
R
H
P
D
-
I
K
W
L
-
R
R
D
R
D
I
P
E
L
A
Q
L
------
Q
S
E
I
L
D
A
--
I
W
P
H
L
K
T
G
G
T
L
V
Y
A
T
C
S
V
L
P
E
E
N
S
----
L
Q
I
K
A
F
L
Q
R
T
A
-----
D
A
E
---
L
C
E
------
T
-
G
----
T
----
P
---------------------
E
------------
Q
P
G
-
K
------------
Q
N
L
----
P
G
A
-
E
E
G
-
D
G
F
F
Y
A
K
L
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
80.24
40%
20
- C2 -
-
1SQG
-
RSMB_ECOLI
A:
[6-428]
-----------
N
L
R
S
M
A
A
Q
A
V
E
Q
V
V
E
Q
-
G
Q
---
S
L
S
N
I
L
P
P
L
Q
Q
--
K
V
S
-
D
K
D
K
A
L
L
Q
E
L
C
F
G
V
L
R
T
L
S
Q
L
D
W
L
I
N
K
L
M
A
R
P
-
M
--
T
--
G
K
Q
R
T
V
H
Y
L
I
M
V
G
L
Y
Q
L
L
Y
T
-
R
I
P
P
H
A
A
L
A
--
E
T
V
E
G
A
I
A
I
K
R
P
Q
L
K
G
L
I
N
G
V
L
R
Q
F
Q
R
Q
Q
-------
E
E
---
L
---
L
A
E
F
---
N
A
S
D
A
R
YLH
P
S
W
L
L
K
R
L
Q
K
A
-
Y
-
P
E
-
Q
W
Q
S
I
V
E
A
N
-
N
Q
-
R
P
-
P
M
-
W
L
R
I
N
R
T
H
H
S
R
D
S
W
L
A
L
L
D
E
A
G
M
K
----------------
G
F
P
------------------
H
A
D
Y
--
P
D
A
--
V
R
L
-
E
-
T
P
A
P
V
H
A
L
P
G
F
E
D
-----
G
W
V
T
V
Q
D
A
S
A
-
Q
G
C
M
T
W
L
-
A
P
Q
N
G
E
H
I
L
-
D
L
C
A
A
P
G
G
K
T
T
H
I
L
E
V
-
A
-
P
-
E
-
A
Q
V
V
-
A
V
D
I
D
E
Q
R
L
S
R
V
Y
D
N
L
K
R
----
L
----
G
M
K
-----
A
T
---
V
K
Q
G
D
-
G
R
Y
P
S
Q
W
------
C
--
G
----
E
---
Q
Q
----
F
D
R
I
L
L
D
A
P
C
S
--
A
T
G
V
I
R
R
H
P
D
-
I
K
W
L
-
R
R
D
R
D
I
P
E
L
A
Q
L
------
Q
S
E
I
L
D
A
--
I
W
P
H
L
K
T
G
G
T
L
V
Y
A
T
C
S
V
L
P
E
E
N
S
----
L
Q
I
K
A
F
L
Q
R
T
A
-----
D
A
E
--
L
C
E
T
----------------------
G
----------
T
-
P
---
E
Q
------------
P
-
G
-
K
------------
Q
N
L
----
P
G
A
-
E
E
G
-
D
G
F
F
Y
A
K
L
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.02
40%
19
- C2 -
-
1SQF
-
RSMB_ECOLI
A:
[6-428]
-----------
N
L
R
S
M
A
A
Q
A
V
E
Q
V
V
E
Q
-
G
Q
---
S
L
S
N
I
L
P
P
L
Q
Q
--
K
V
S
-
D
K
D
K
A
L
L
Q
E
L
C
F
G
V
L
R
T
L
S
Q
L
D
W
L
I
N
K
L
M
A
R
P
-
M
--
T
--
G
K
Q
R
T
V
H
Y
L
I
M
V
G
L
Y
Q
L
L
Y
T
-
R
I
P
P
H
A
A
L
A
--
E
T
V
E
G
A
I
A
I
K
R
P
Q
L
K
G
L
I
N
G
V
L
R
Q
F
Q
R
Q
Q
-------
E
E
---
L
---
L
A
E
F
---
N
A
S
D
A
R
YLH
P
S
W
L
L
K
R
L
Q
K
A
-
Y
-
P
E
-
Q
W
Q
S
I
V
E
A
N
-
N
Q
-
R
P
-
P
M
-
W
L
R
I
N
R
T
H
H
S
R
D
S
W
L
A
L
L
D
E
A
G
M
K
----------------
G
F
P
------------------
H
A
D
Y
--
P
D
A
--
V
R
L
-
E
-
T
P
A
P
V
H
A
L
P
G
F
E
D
-----
G
W
V
T
V
Q
D
A
S
A
-
Q
G
C
M
T
W
L
-
A
P
Q
N
G
E
H
I
L
-
D
L
C
A
A
P
G
G
K
T
T
H
I
L
E
V
-
A
-
P
-
E
-
A
Q
V
V
-
A
V
D
I
D
E
Q
R
L
S
R
V
Y
D
N
L
K
R
----
L
----
G
M
K
-----
A
T
---
V
K
Q
G
D
-
G
R
Y
P
S
Q
W
------
C
--
G
----
E
---
Q
Q
----
F
D
R
I
L
L
D
A
P
C
S
--
A
T
G
V
I
R
R
H
P
D
-
I
K
W
L
-
R
R
D
R
D
I
P
E
L
A
Q
L
------
Q
S
E
I
L
D
A
--
I
W
P
H
L
K
T
G
G
T
L
V
Y
A
T
C
S
V
L
P
E
E
N
S
----
L
Q
I
K
A
F
L
Q
R
T
A
-----
D
A
E
--
L
C
E
T
----------------------
G
----------
T
-
P
---
E
Q
------------
P
-
G
-
K
------------
Q
N
L
----
P
G
A
-
E
E
G
-
D
G
F
F
Y
A
K
L
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
63.72
22%
36
- C2 -
-
2YXL
1
?
A:
[6-448]
--------
K
K
L
S
I
P
P
K
G
I
R
A
I
I
E
A
-
I
R
L
G
E
I
IK
P
S
Q
Y
A
K
R
E
A
F
K
K
H
D
V
E
E
A
W
L
N
R
V
L
T
M
I
F
Y
D
I
M
K
K
Q
G
L
I
D
K
V
I
K
E
I
V
G
V
T
P
L
I-
L
--
D
P
--
W
L
R
A
A
L
R
V
A
V
D
I
A
L
F
H
D
P
S
S
Q
T
I
K
N
L
R
W
K
A
S
D
F
I
S
S
R
T
H
P
Y
V
G
M
Y
F
W
D
L
L
D
K
I
F
E
Y
K
-------
P
N
P
K
N
E
---
L
E
E
L
---
E
W
K
Y
L
A
---
P
S
W
L
I
E
R
V
K
G
I
-
L
G
D
E
--
T
E
D
F
F
R
S
V
-
N
K
R
H
E
-
W
I
-
S
I
R
V
N
T
L
K
A
N
V
E
E
V
I
G
E
L
E
E
D
G
V
E
----------------
V
V
R
------------------
S
E
R
V
--
P
T
I
--
L
K
I
-
K
-
G
P
Y
N
F
D
T
S
S
A
F
N
E
-----
G
K
I
I
V
Q
E
E
A
S
-
A
V
A
S
I
V
L
D
P
K
-
P
G
E
T
V
V
-
D
L
A
A
A
P
G
G
K
T
T
H
L
A
E
L
-
M
-
K
-
N
K
G
K
I
Y
-
A
F
D
V
D
K
M
R
M
K
R
L
K
D
F
V
K
R
----
M
----
G
I
------
K
I
V
--
K
--
P
L
-
V
K
D
A
R
K
A
------
P
EI
I
----
G
---
E
E
V---
A
D
K
V
L
L
D
A
P
C
T
--
S
S
G
T
I
G
K
N
P
E
-
L
R
W
R
-
L
R
E
D
K
I
N
E
M
S
Q
L
------
Q
R
E
L
L
E
S
--
A
A
R
L
V
K
P
G
G
R
L
L
Y
T
T
C
S
I
F
K
E
E
N
E
----
K
N
I
R
W
F
L
N
V
H
P
-----
E
F
K
---
L
V
P
------
L
-
K
----
S
----
P
---
Y
----------
D
-
P
G
--
F
L
------------
E
G
T
-
M
------------
R
A
W
----
P
H
R
-
H
S
T
-
I
G
F
F
Y
A
L
L
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
58.00
20%
19
* C2 *
-
2YXL
1
?
A:
[6-448]
-
K
K
L
S
I
P
P
K
G
I
R
A
I
I
E
A
I
R
L
G
E
I
I
-
K
P
-
S
Q
---
Y
A
K
R
E
A
F
K
K
H
D
--
V
E
E
-
A
W
L
N
R
V
L
T
M
I
F
Y
D
I
M
K
K
Q
G
L
I
D
K
V
I
K
E
I
V
G
V
T
-
P
--
L
IL
D
P
--
W
L
R
A
A
L
R
V
A
V
D
I
A
L
F
--
H
D
P
S
S
Q
T
I
K
--
N
L
R
W
K
A
S
D
F
I
S
S
R
T
H
P
Y
V
G
M
Y
F
W
D
L
L
D
K
I
F
E
Y
K
P
N
P
K
N
---
E
---
L
E
E
L
---
E
W
K
Y
L
A
---
P
S
W
L
I
E
R
V
K
G
I
-
L
G
D
E
-
T
E
D
F
F
R
S
V
N
-
K
R
-
H
E
-
W
I
-
S
I
R
V
N
T
L
K
A
N
V
E
E
V
I
G
E
L
E
E
D
G
V
E
----------------
V
V
R
------------------
S
E
R
V
--
P
T
I
--
L
K
I
-
K
-
G
P
Y
N
F
D
T
S
S
A
F
N
E
-----
G
K
I
I
V
Q
E
E
A
S
-
A
V
A
S
I
V
L
-
D
P
K
P
G
E
T
V
V
-
D
L
A
A
A
P
G
G
K
T
T
H
L
A
E
L
-
M
-
K
N
K
-
G
K
I
Y
-
A
F
D
V
D
K
M
R
M
K
R
L
K
D
F
V
K
R
----
M
----
G
I
K
-----
I
V
---
K
P
L
V
K
D
A
R
K
A
P
E
I
------
I
--
G
----
E
---
E
V
----
A
D
K
V
L
L
D
A
P
C
T
--
S
S
G
T
I
G
K
N
P
E
-
L
R
W
R
-
L
R
E
D
K
I
N
E
M
S
Q
L
------
Q
R
E
L
L
E
S
--
A
A
R
L
V
K
P
G
G
R
L
L
Y
T
T
C
S
I
F
K
E
E
N
E
----
K
N
I
R
W
F
L
N
V
H
P
-----
E
F
K
--
L
V
P
L
------
K
-
S
----
P
----
Y
---
D
----------
P
-
G
---
F
L
------------
E
-
G
T
M
------------
R
A
W
----
P
H
R
-
H
S
T
-
I
G
F
F
Y
A
L
L
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
57.00
27%
22
- C2 -
-
1IXK
-
?
A:
[10-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
L
L
R
L
G
Y
---
S
K
L
F
A
D
R
Y
F
Q
L
-
W
G
E
R
--
A
I
R
I
A
E
A
M
-
E
K
-
P
L
-
P
R
-
C
F
R
V
N
T
L
K
I
S
V
Q
D
L
V
K
R
L
N
K
K
G
F
Q
----------------
F
K
R
------------------
V
P
W
A
--
K
E
G
--
F
C
L
-
T
R
E
P
F
S
I
T
S
T
P
E
F
L
T
-----
G
L
I
Y
I
Q
E
A
S
S
-
M
Y
P
P
V
A
L
D
P
K
-
P
G
E
I
V
A
-
D
M
A
A
A
P
G
G
K
T
S
Y
L
A
Q
L
-
M
-
R
-
N
D
G
V
I
Y
-
A
F
D
V
D
E
N
R
L
R
E
T
R
L
N
L
S
R
----
L
----
G
V
------
L
N
V
--
I
--
L
F
-
H
S
S
S
L
H
I
------
G
--
E
----
L
---
N
V
E---
F
D
K
I
L
L
D
A
P
C
T
--
G
S
G
T
I
H
----------
R
T
M
D
D
I
K
F
C
Q
G
L
------
Q
M
R
L
L
E
K
--
G
L
E
V
L
K
P
G
G
I
L
V
Y
S
T
C
S
L
E
P
E
E
N
E
----
F
V
I
Q
W
A
L
D
N
F
D
------
V
E
---
L
L
P
------
L
-
K
----
Y
GE--
P
A--
L
TNPF------
G
I
E
LSE
E
I
------------
K
N
A
-
R
------------
R
L
Y
----
P
D
V
-
H
E
T
-
S
G
F
F
I
A
K
I
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
56.60
23%
4
- C2 -
-
2FRX
-
RSMF_ECOLI
A:
[7-474]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
P
D
A
F
L
T
Q
M
R
-
E
A
M
P
F
D
D
F
L
A
A
C
-
Q
R
-
P
L
-
R
R
-
S
I
R
V
N
T
L
K
I
S
V
A
D
F
L
Q
L
T
A
P
Y
G
W
T
----------------
L
T
P
------------------
I
P
W
C
--
E
E
G
--
F
W
P
-
L
-
G
S
T
A
E
H
L
-----
S
-----
G
L
F
Y
I
Q
E
A
S
S
M
L
P
V
A
A
L
F
-
A
D
G
N
A
P
Q
R
V
M
D
V
A
A
A
P
G
S
K
T
T
Q
I
S
A
R
M
N
-
N
-
E
-
G
A
I
L
-
A
N
E
F
S
A
S
R
V
K
V
L
H
A
N
I
S
R
----
C
----
G
I
-------
S
---
N
V
A
L
T
-
H
F
D
G
R
V
F
------
G
--
A
A---
V
---
P
E
M---
F
D
A
I
L
L
D
A
P
C
S
--
G
E
G
V
V
R
K
D
P
D
-
A
L
K
N
-
W
S
P
E
S
N
Q
E
I
A
A
T
------
Q
R
E
L
I
D
S
--
A
F
H
A
L
R
P
G
G
T
L
V
Y
S
T
C
T
L
N
Q
E
E
N
E
----
A
V
C
L
W
L
K
E
T
Y
P
-----
D
A
V
--
E
F
L
P
LGDLFP
G
-
A
----
N
----
K
---
A
----------
L
-
T
---
E
E
------------
G
-
F
-
L
------------
H
V
F
----
P
Q
I
-
Y
D
C
-
E
G
F
F
V
A
R
L
R
K
T
Q
AIPALPAPKYKVGNFPFSPVK
D
R
E
A
G
Q
I
R
Q
A
A
T
G
V
G
L
N
W
D
EN
L
R
L
W
Q
R
D
K
E
L
W
L
F
P
VGIEALIGKVRFSRLGIKL
A
E
T
H
NKGYRWQ
H
E
A
V
I
A
LASPDNMN
A
F
E
L
T
P
Q
E
A
E
E
W
Y
R
G
R
D
V
Y
P
QAAPVADDVLVTFQHQPI
G
L
A
K
R
IGS
R
L
K
N
SYPRELVRDGKL
3
PsiBlast_PDB
55.95
28%
27
- C2 -
-
2YXL
1
?
A:
[151-448]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
E
W
K
Y
L
A
---
P
S
W
L
I
E
R
V
K
G
I
-
L
-
G
D
-
E
T
E
D
F
F
R
S
V
N
K
R
-
H
E
-
W
I
-
S
I
R
V
N
T
L
K
A
N
V
E
E
V
I
G
E
L
E
E
D
G
V
E
----------------
V
V
R
------------------
S
E
R
V
--
P
T
I
--
L
K
I
-
K
-
G
P
Y
N
F
D
T
S
S
A
F
N
E
-----
G
K
I
I
V
Q
E
E
A
S
-
A
V
A
S
I
V
L
-
D
P
K
P
G
E
T
V
V
-
D
L
A
A
A
P
G
G
K
T
T
H
L
A
E
L
-
M
-
K
N
K
-
G
K
I
Y
-
A
F
D
V
D
K
M
R
M
K
R
L
K
D
F
V
K
R
----
M
----
G
I
-------
K
---
I
V
K
P
L
-
V
K
D
A
R
K
A
------
P
--
E
----
I
IGE
E
V
----
A
D
K
V
L
L
D
A
P
C
T
--
S
S
G
T
I
G
K
N
P
E
-
L
R
W
R
-
L
R
E
D
K
I
N
E
M
S
Q
L
------
Q
R
E
L
L
E
S
--
A
A
R
L
V
K
P
G
G
R
L
L
Y
T
T
C
S
I
F
K
E
E
N
E
----
K
N
I
R
W
F
L
N
V
H
P
-----
E
F
K
--
L
V
P
L
------
K
-
S
----
P
----
Y
---
D
----------
P
-
G
---
F
L
------------
E
-
G
T
M
------------
R
A
W
----
P
H
R
-
H
S
T
-
I
G
F
F
Y
A
L
L
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
55.81
26%
5
- C2 -
-
3M6V
-
RSMF_THET8
A:
[2-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
P
K
A
F
L
S
R
M
A
E
L
-
L
-
G
E
-
E
F
P
A
F
L
K
A
L
-
T
E
-
G
K
R
T
Y
-
G
L
R
V
N
T
L
K
L
P
P
E
A
F
-
Q
R
I
S
P
W
P
L
------------------
R
P
------------------
I
P
W
C
--
Q
E
G
--
F
Y
Y
-
P
-
E
E
A
R
P
G
P
H
P
F
F
Y
A
-----
G
L
Y
Y
I
Q
E
P
S
A
-
Q
A
V
G
V
L
L
-
D
P
K
P
G
E
R
V
L
-
D
L
A
A
A
P
G
G
K
T
T
H
L
A
A
R
-
M
G
G
-
K
-
G
L
L
L
-
A
N
E
V
D
G
K
R
V
R
G
L
L
E
N
V
E
R
W
G
A
P
L
----
A
V
T
-----
Q
A
---
P
P
R
A
L
-
A
E
A
F
G
T
Y
------------------------
F
H
R
V
L
L
D
A
P
C
S
--
G
E
G
M
F
R
K
D
R
E
-
A
A
R
H
-
W
G
P
S
A
P
K
R
M
A
E
V
------
Q
K
A
L
L
A
Q
--
A
S
R
L
L
G
P
G
G
V
L
V
Y
S
T
C
T
F
A
P
E
E
N
E
----
G
V
V
A
H
F
L
K
A
H
P
E
F
R
L
E
D
A
R
--
L
H
P
L
------
F
-
A
P
G
V
P
E
----
W
---
G
EGN-------
P
-
E
---
L
L
------------
K
-
T
-
A
------------
R
L
W
----
P
H
R
-
L
E
G
-
E
G
H
F
L
A
R
F
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
54.46
28%
-2
- C2 -
-
1IXK
-
?
A:
[28-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-
G
E
-
R
A
I
R
I
A
E
A
M
-
E
K
-
P
L
-
P
R
-
C
F
R
V
N
T
L
K
I
S
V
Q
D
L
V
K
R
L
N
K
K
G
F
Q
----------------
F
K
R
------------------
V
P
W
A
--
K
E
G
--
F
C
L
T
R
-
E
P
F
S
I
T
S
T
P
E
F
L
T
-----
G
L
I
Y
I
Q
E
A
S
S
-
M
Y
P
P
V
A
L
-
D
P
K
P
G
E
I
V
A
-
D
M
A
A
A
P
G
G
K
T
S
Y
L
A
Q
L
-
M
-
R
-
N
-
D
G
V
I
Y
A
F
D
V
D
E
N
R
L
R
E
T
R
L
N
L
S
R
----
L
----
G
V
L
-----
N
V
I
L
F
H
S
S
S
L
-
H
I
G
E
L
N
V
------
E
-----------------
F
D
K
I
L
L
D
A
P
C
T
--
G
S
G
T
I
H
----------
R
T
M
D
D
I
K
F
C
Q
G
L
------
Q
M
R
L
L
E
K
--
G
L
E
V
L
K
P
G
G
I
L
V
Y
S
T
C
S
L
E
P
E
E
N
E
F
V
I
Q
W
A
L
D
N
F
D
V
E
L
L
-----
P
L
K
Y
G
E
P
A
L
------
T
-
N
----
P
----
F
---
G
----------
I
-
E
---
L
S
EEIK--------
N
-
A
-
R
------------
R
L
Y
----
P
D
V
-
H
E
T
-
S
G
F
F
I
A
K
I
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
50.77
23%
-43
- C2 -
-
4FP9
-
NSUN4_HUMAN
A:
[15-360]
--------------------------------------------------
P
A
V
R
L
A
L
Q
N
F
D
M
T
Y
S
V
Q
F
G
D
L
W
P
S
I
R
V
S
L
L
S
E
-
Q
--
K
----------------
Y
G
A
L
V
N
-
N
F
A
A
W
D
H
V
S
--
A
K
L
E
Q
L
S
------
A
K
D
F
V
N
E
A
I
S
H
W
E
L
Q
P
-------
S
P
---
A
---
S
W
A
C
---
S
P
--
N
L
---
R
C
F
T
F
D
R
G
D
I
S
-------------
R
F
-
P
P
-
A
R
-
P
G
-
S
L
G
V
M
E
Y
Y
L
M
D
A
A
S
L
L
P
V
L
A
L
G
L
Q
----------------------------------------------------------------------------------------------
P
G
D
I
V
L
-
D
L
C
A
A
P
G
G
K
T
L
A
L
L
Q
T
-
G
-
C
-
C
-
R
N
L
A
-
A
N
D
L
S
P
S
R
I
A
R
L
Q
K
I
L
H
S
----
Y
VP
E
E
I
R
D
-----
G
N
---
Q
V
R
V
T
-
S
W
D
G
R
K
W
------
G
--
E
----
L
---
E
G
DT--
Y
D
R
V
L
V
D
V
P
C
T
T
D
R
H
S
L
H
E
E
E
N
N
-
I
F
K
R
-
S
R
K
K
E
R
Q
I
L
P
V
L
------
Q
V
Q
L
L
A
A
--
G
L
L
A
T
K
P
G
G
H
V
V
Y
S
T
C
S
L
S
H
L
Q
N
E
----
Y
V
V
Q
G
A
I
E
L
L
A
-----
N
Q
Y
S
I
Q
V
Q
V
------
E
-
D
----
L
----
T
---
H
----------
F
-
R
---
R
V
F
MDTFCFFSSCQ
V
-
G
-
E
------------
L
V
I
----
P
N
L
-
M
A
N
F
G
P
M
Y
F
C
K
M
R
R
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
50.43
24%
-24
- C2 -
-
3M6W
-
RSMF_THET8
A:
[4-460]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
P
K
A
F
L
S
R
M
A
E
L
-
L
-
G
E
-
E
F
P
A
F
L
K
A
L
-
T
E
-
G
K
-
R
T
Y
G
L
R
V
N
T
L
K
L
P
P
E
A
F
Q
R
I
S
P
W
---
P
----------------
L
R
P
------------------
I
P
W
C
--
Q
E
G
--
F
Y
Y
-
P
-
E
E
A
R
P
G
P
H
P
F
F
Y
A
-----
G
L
Y
Y
I
Q
E
P
S
A
-
Q
A
V
G
V
L
L
-
D
P
K
P
G
E
R
V
L
-
D
L
A
A
A
P
G
G
K
T
T
H
L
A
A
R
-
M
-
G
G
K
-
G
L
L
L
-
A
N
E
V
D
G
K
R
V
R
G
L
L
E
N
V
E
R
----
W
----
G
A
P
-----
L
A
---
V
T
Q
A
P
-
P
R
A
L
A
E
A
------
F
--
G
--------
T
Y
----
F
H
R
V
L
L
D
A
P
C
S
--
G
E
G
M
F
R
K
D
R
E
-
A
A
R
H
-
W
G
P
S
A
P
K
R
M
A
E
V
------
Q
K
A
L
L
A
Q
--
A
S
R
L
L
G
P
G
G
V
L
V
Y
S
T
C
T
F
A
P
E
E
N
E
----
G
V
V
A
H
F
L
K
A
H
P
-----
E
F
R
--
L
E
D
A
------
R
-
L
----
H
----
P
---
L
----------
F
-
A
---
P
G
------------
V
-
P
-
E
WGEGNPELLK
T
A
R
L
W
----
P
H
R
-
L
E
G
-
E
G
H
F
L
A
R
F
R
K
E
G
G
A
W
S
T
P
RLERPSPLS
Q
E
A
L
R
A
F
R
G
F
L
E
E
A
G
L
T
L
E
G
P
V
L
D
R
AGHLYLLPEGLPTLLGLKAPAPGLYL
G
K
V
Q
KG
R
F
L
P
A
R
A
L
A
L
A
FGATLPWPEG
L
P
R
L
A
L
T
PED
P
R
A
L
A
F
A
T
G
E
G
V
A
W
E
G
E
D
H
P
L
A
L
V
V
L
K
T
AAGEFPL
D
F
G
K
A
K
RG
V
L
R
P
V
G
V
G
L
R
S
H
H---
40
HHSearch
50.18
24%
-2
- C2 -
-
2B9E
-
NSUN5_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
-
P
R
-
F
V
R
V
N
T
L
K
T
C
S
D
D
V
V
D
Y
F
K
R
Q
G
F
S
----------------
Y
Q
G
RASS
L
D
D
L
R
A
LKGK
H
F
L
L
D
P
L
M
--
P
E
L
--
L
V
F
-
P
-
A
Q
T
D
L
H
E
H
P
L
Y
R
A
-----
G
H
L
I
L
Q
D
R
A
S
-
C
L
P
A
M
L
L
D
P
P
-
P
G
S
H
V
I
-
D
A
C
A
A
P
G
N
K
T
S
H
L
A
A
L
-
L
-
K
-
N
Q
G
K
I
F
-
A
F
D
L
D
A
K
R
L
A
S
M
A
T
L
L
A
R
----
A
----
G
V
------
S
C
C--
E
--
L
A
-
E
E
D
F
L
A
V
------
S
--
P
SDP-
R
---
Y
H
E---
V
H
Y
I
L
L
D
P
S
C
S
--
G
------------------
V
R
L
H
A
L
A
G
F
------
Q
Q
R
A
L
C
H
--
A
L
T
F
-
P
S
L
Q
R
L
V
Y
S
T
C
S
L
C
Q
E
E
N
E
----
D
V
V
R
D
A
L
Q
Q
N
P
G----
A
F
R
---
L
A
P
------
A
-
L
----
P
----
A
---
W
PHR-------
G
L
S
TFP
G
A
------------
E
H
C
-
L
------------
R
A
S
----
P
E
T
-
T
L
S
-
S
G
F
F
V
A
V
I
E
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
49.04
26%
-1
- C2 -
-
3M6U
-
RSMF_THET8
A:
[5-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
L
S
R
M
A
E
L
-
L
-
G
E
-
E
F
P
A
F
L
K
A
L
-
T
E
-
G
K
R
T
Y
-
G
L
R
V
N
T
L
K
L
P
P
E
A
F
-
Q
R
I
S
P
W
P
L
------------------
R
P
------------------
I
P
W
C
--
Q
E
G
--
F
Y
Y
-
P
-
E
E
A
R
P
G
P
H
P
F
F
Y
A
-----
G
L
Y
Y
I
Q
E
P
S
A
-
Q
A
V
G
V
L
L
-
D
P
K
P
G
E
R
V
L
-
D
L
A
A
A
P
G
G
K
T
T
H
L
A
A
R
-
M
G
G
-
K
-
G
L
L
L
-
A
N
E
V
D
G
K
R
V
R
G
L
L
E
N
V
E
R
W
G
A
P
L
----
A
V
T
-----
Q
A
---
P
P
R
A
L
-
A
E
A
F
G
T
Y
------------------------
F
H
R
V
L
L
D
A
------------------
R
H
-
W
G
P
--
P
K
R
M
A
E
V
------
Q
K
A
L
L
A
Q
--
A
S
R
L
L
G
P
G
G
V
L
V
Y
S
T
C
T
F
A
P
E
E
N
E
----
G
V
V
A
H
F
L
K
A
H
P
E
F
R
L
E
D
A
R
--
L
H
P
L
------
F
-
A
P
G
V
P
E
----
W
---
G
EGN-------
P
-
E
---
L
L
------------
K
-
T
-
A
------------
R
L
W
----
P
H
R
-
L
E
G
-
E
G
H
F
L
A
R
F
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
47.09
24%
-23
- C2 -
-
3AJD
2
TRM4_METJA
A:
[13-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
V
N
T
L
K
I
N
P
E
V
L
K
K
R
L
E
N
K
G
V
V
----------------
L
E
K
------------------
T
F
L
D
--
Y
A
F
--
E
V
K
-
K
-
S
P
F
S
I
G
S
T
P
E
Y
L
F
-----
G
Y
Y
M
P
Q
S
I
S
S
-
M
I
P
P
I
V
L
-
N
P
R
E
D
D
F
I
L
-
D
M
C
A
A
P
G
G
K
T
T
H
L
A
Q
L
-
M
-
K
N
K
-
G
T
I
V
-
A
V
E
I
S
K
T
R
T
K
A
L
K
S
N
I
N
R
----
M
----
G
V
-------
L
---
N
T
I
I
I
-
N
A
D
M
R
K
Y
K
D
Y
L
L
K
N
--
E
----
I
---
F
-----
F
D
K
I
L
L
D
A
P
C
S
--------------------
E
E
D
I
K
Y
C
S
L
R
------
Q
K
E
L
I
D
I
--
G
I
D
L
L
K
K
D
G
E
L
V
Y
S
T
C
S
M
E
V
E
E
N
E
----
E
V
I
K
Y
I
L
Q
K
R
N
-----
D
V
E
--
L
I
I
I
------
K
-
A
----
N
EFKG
I
---
N
----------
I
-
K
---
E
G
------------
Y
-
I
-
K
------------
G
T
L
----
R
V
F
-
P
P
N
-
E
P
F
F
I
A
K
L
R
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
46.53
28%
-32
- C2 -
-
2B9E
-
NSUN5_HUMAN
A:
[79-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
A
-----
G
H
L
I
L
Q
D
R
A
S
-
C
L
P
A
M
L
L
-
D
P
P
P
G
S
H
V
I
-
D
A
C
A
A
P
G
N
K
T
S
H
L
A
A
L
-
L
-
K
-
N
Q
G
K
I
F
-
A
F
D
L
D
A
K
R
L
A
S
M
A
T
L
L
A
R
----
A
----
G
V
-------
S
---
C
C
E
L
A
-
E
E
D
F
L
A
V
------
S
--
P
----
S
---
D
P
RYHE
V
H
Y
I
L
L
D
P
S
C
S
--
G
------------------------
V
R
L
H
A
L
A
G
F
Q
Q
R
A
L
C
H
A
L
T
F
P
S
L
Q
---
R
L
V
Y
S
T
C
S
L
C
Q
E
E
N
E
----
D
V
V
R
D
A
L
Q
Q
N
P
-----
G
A
F
--
R
L
A
P
------
A
L
P
----
A
----
W
PHR
G
----------
L
-
S
---
T
F
------------
P
-
G
-
A
------------
E
H
C
L
R
A
S
P
E
T
-
T
L
S
-
S
G
F
F
V
A
V
I
E
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
46.39
25%
7
- C2 -
-
3AJD
2
TRM4_METJA
A:
[9-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
M
Q
-
F
I
R
V
N
T
L
K
I
N
P
E
V
L
K
K
R
L
E
N
K
G
V
V
----------------
L
E
K
------------------
T
-
F
L
--
D
Y
A
--
F
E
V
-
K
K
S
P
F
S
I
G
S
T
P
E
Y
L
F
-----
G
Y
Y
M
P
Q
S
I
S
S
-
M
I
P
P
I
V
L
N
P
R
-
E
D
D
F
I
L
-
D
M
C
A
A
P
G
G
K
T
T
H
L
A
Q
L
-
M
-
K
-
N
K
G
T
I
V
-
A
V
E
I
S
K
T
R
T
K
A
L
K
S
N
I
N
R
----
M
----
G
V
------
L
N
T
--
I
--
I
I
-
N
A
D
M
R
K
Y
------
K
--
D
Y
L
L
K
N
---
E
I
F---
F
D
K
I
L
L
D
A
P
C
S
--------------------
E
E
D
I
K
Y
C
S
L
R
------
Q
K
E
L
I
D
I
--
G
I
D
L
L
K
K
D
G
E
L
V
Y
S
T
C
S
M
E
V
E
E
N
E
----
E
V
I
K
Y
I
L
Q
K
R
N
-----
D
V
E
---
L
I
I
------
I
-
K
----
A
----
N
E--
F
KGI-------
N
I
K
E
G
-
Y
I
------------
K
G
T
-
L
------------
R
V
F
----
P
P
----
N
-
E
P
F
F
I
A
K
L
R
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
45.98
22%
16
- C2 -
-
4FZV
2
NSUN4_HUMAN
A:
[22-358]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
D
M
T
Y
S
V
Q
-
F
G
D
L
--
W
P
S
I
R
V
S
L
-
L
S
-
E
Q
-
K
Y
-
G
A
L
V
N
N
F
A
A
W
-
D
H
V
S
A
K
L
E
Q
L
S
A
K
D
F
V
N
E
A
I
S
H
W
ELQSAA
P
S
P
------------------
A
S
W
A
CS
P
N
L
R
C
F
T
F
-
D
--
R
G
D
I
S
R
F
P
P
A
R
P
G
SLGV
M
E
Y
Y
L
M
D
A
A
S
-
L
L
P
V
L
A
L
G
L
Q
-
P
G
D
I
V
L
-
D
L
C
A
A
P
G
G
K
T
L
A
L
L
Q
T
-
G
-
C
-
C
-
R
N
L
A
-
A
N
D
L
S
P
S
R
I
A
R
L
Q
K
I
L
H
S
----
Y
----
V
P
E
EIRDG
N
Q
V
--
R
--
V
T
-
S
W
D
G
R
K
W
------
G
E-
L
----
E
---
G
D
T---
Y
D
R
V
L
V
D
V
P
C
T
--
T
D
R
H
S
L
H
E
E
E
N
N
I
F
K
R
S
R
K
K
E
R
Q
I
L
P
V
L
------
Q
V
Q
L
L
A
A
--
G
L
L
A
T
K
P
G
G
H
V
V
Y
S
T
C
S
L
S
H
L
Q
N
E
----
Y
V
V
Q
G
A
I
E
L
L
A
N
QY--
S
I
Q
---
V
Q
V
------
E
-
D
----
L
----
T
H
--
F
R
R
V
F
MDTFCF
F
-
S
---
S
C
------------
Q
V
G
-
E
------------
L
V
I
----
P
N
L
M
A
N
F
-
G
P
M
Y
F
C
K
M
R
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------