@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQ25: (2017-11-24 )
MHLHILGICGTFMGSLALLARDLGHKVTGSDSNVYPPMSTQLENAGIELMQGYDRSHLQPHPDLVIVGNAMKRGIDAVEYMLNEGLPYISGPQFLADHVLQGKHVLGVAGTHGKTTTTTMLAWVLDQAGLNPGFLIGGVPLGFSESARLGGGKYFVVEADEYDSAFFDKRSKFVHYHPKTAILNNLEFDHADIFDDLAAIQKQFHHLVRTIPSEGRIIAPITETHIDEVLEMGCWTPVIRTSLEANEKAALSAELISIDGSHFKVLENGNVIGEVKWSMTGQHSVANALATIAAAQHVGVSLEKACEALSNFGGVKRRMELLGTVNGIEVYDDFAHHPTAIDTTLDGARKRLGERRLWAIIEPRSNTMRMGSHKDGLAHSARLADEVIWYQPEGLDWDLQPVIEAATNHAQVSRSLDEIIDRIVNEAGEGDAVVIMSNGGFGGLHQKLMSALKAKAA
Atome Classification :
(20 SA)
.........10........20........30......--..40-........50.......-.-60........70........80........90........100........110.......120.......130.....-..140---------.------..------..--------------..-.---------150.----------......160.......170.......180.......190..-.-....200.......210.......220.......230.-----..-.--....240.--..-....250....--.--.--.260--.......--270.........280.......290.......300.......310.......320.----.---------.---..-..----330..-.....340.......350.......360.......370.......380.......390----.....------....400....-----..------..----410-------.......420.......430.......440.......450.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
H
L
H
I
L
G
I
C
G
T
F
M
G
S
L
A
L
L
A
R
D
LGHKVTGSDSNVYPP--
M
S
T
Q
-
L
E
N
A
G
I
E
L
M
QGYDRSHL-Q-PHP
D
L
V
I
V
G
N
A
M
K
R
G
I
D
A
V
E
Y
M
L
NEGLPYIS
G
P
Q
F
L
A
D
H
V
L-QG
K
H
V
L
G
VAGTHGK
T
T
T
T
T
M
L
A
W
V
L
D
QAGLNP
G
F
L
IG-GVPL----------G------FS------ES--------------AR-L---------GG
G
K
----------
Y
F
V
V
EADEY
D
S
A
F
F
D
KRS
K
F
V
H
YHP
K
T
A
I
LNNLEFD
H
A
D
I
F
-
D
-
D
L
A
A
I
Q
K
Q
F
H
H
L
V
R
TIPSEG
R
I
I
A
P
I
T
E
T
H
I
D
E
V
L
-
E
M-----GC-W--
T
P
V
I
R
TSL--EA-NEKAA
L
S
A
E
L
I
--
S
--I--DGS
H
--
F
K
V
L
ENG--
N
--
V
I
G
E
V
K
W
SMTG
Q
H
S
V
A
N
A
L
A
T
I
A
A
A
Q
H
VG
V
S
L
E
K
A
C
E
A
L
S
N
F
G
G
V
K
R
R
M
E
L
L
G----T---------V---NG-
I
E
----
V
Y
DDF-AHHPTAID
T
T
L
D
G
A
R
K
R
LGER
R
L
W
A
I
IEPRSN
T
M
RMGSHKDG
L
A
H
S
A
R
LAD
E
V
I
W
Y------QPEGL------DW
D
L
Q
-
P
V
I
E
A-----AT------
N
H
----
A
Q
V
-------
S
R
S
L
D
E
I
I
D
R
I
V
NEAGEG
D
A
V
V
I
MSNGGF
G
G
L
H
Q
K
L
M
S
A
L
K
AKAA
1
HHSearch
81.71
63%
-52
- C- -
-
3HN7
-
?
A:
[1-502]
M
H
I
H
I
L
G
I
C
G
T
F
M
G
S
L
A
L
L
A
R
A
L
G
H
T
V
T
G
S
D
A
N
I
Y
P
P
--
M
S
T
Q
-
L
E
Q
A
G
V
T
I
E
E
G
Y
L
I
A
H
L
-
Q
-
P
A
P
D
L
V
V
V
G
N
A
M
K
R
G
M
D
V
I
E
Y
M
L
D
T
G
L
R
Y
T
S
G
P
Q
F
L
S
E
Q
V
L
-
Q
S
R
H
V
I
A
V
A
G
T
H
G
K
T
T
T
T
T
M
L
A
W
I
L
H
Y
A
G
I
D
A
G
F
L
I
G
-
G
V
P
L
----------
V
NTTD
T
N
L
Q
------
Q
V
F
AHSSYLGTEKDDS
D
N
-
S
---------
V
N
T
G
----------
Y
F
V
I
E
A
D
E
Y
D
S
A
F
F
D
K
R
S
K
F
V
H
Y
R
P
R
T
A
I
L
N
N
L
E
F
D
--------
D
L
D
A
I
Q
T
Q
F
H
H
M
V
R
M
I
P
S
T
G
K
I
I
M
P
A
A
T
I
S
L
E
D
T
L
-
A
K
GVW
T
P
I
W
-
R
T
S
V
I
D
-------
N
S
-
S
D
W
---
Q
A
E
L
I
--
S
--
A
--
D
G
S
Q
--
F
T
V
S
F
N
D
NK
E
--
A
T
A
L
V
N
W
S
M
S
G
L
H
N
V
N
N
A
L
V
A
I
A
A
A
Y
N
I
G
V
S
V
K
T
A
C
A
A
L
S
A
F
A
G
I
K
R
R
M
E
L
I
G
----
D
---------
V
---
N
D
-
I
L
----
V
F
D
D
F
-
A
H
H
P
T
A
I
T
T
T
L
D
G
A
K
K
K
L
A
D
R
R
L
W
A
I
I
E
P
R
S
N
T
M
K
M
G
I
H
Q
D
S
L
A
Q
S
A
T
L
A
D
H
T
L
W
Y
------
E
P
T
G
L
------
E
W
G
L
K
E
V
I
D
N
A
T
I
A
NP
S
I
------
G
S
----
Q
Q
V
-------
L
S
S
V
D
D
I
I
K
H
I
C
T
H
A
K
A
G
D
A
I
V
I
M
S
N
G
G
F
E
G
I
H
Q
R
L
L
T
A
L
G
N
I
V
-
26
PsiBlast_PDB
81.50
58%
-51
- C- -
-
3HN7
-
?
A:
[2-498]
-
H
I
H
I
L
G
I
C
G
T
F
M
G
S
L
A
L
L
A
R
A
L
G
H
T
V
T
G
S
D
A
N
I
Y
P
P
--
M
S
T
Q
-
L
E
Q
A
G
V
T
I
E
E
G
Y
L
I
A
H
L
-
Q
-
P
A
P
D
L
V
V
V
G
N
A
M
K
R
G
M
D
V
I
E
Y
M
L
D
T
G
L
R
Y
T
S
G
P
Q
F
L
S
E
Q
V
L
-
Q
S
R
H
V
I
A
V
A
G
T
H
G
K
T
T
T
T
T
M
L
A
W
I
L
H
Y
A
G
I
D
A
G
F
L
I
G
-
G
V
P
L
VNTTD
T
N
L
Q
Q
V
------
F
A
------
H
S
--------------
S
Y
-
L
---------
G
T
E
K
DDSDNSVNTG
Y
F
V
I
E
A
D
E
Y
D
S
A
F
F
D
K
R
S
K
F
V
H
Y
R
P
R
T
A
I
L
N
N
L
E
F
D
--------
D
L
D
A
I
Q
T
Q
F
H
H
M
V
R
M
I
P
S
T
G
K
I
I
M
P
A
A
T
I
S
L
E
D
T
L
-
A
K
-----
G
V
-
W
--
T
P
I
W
R
T
S
V
I
D----
N
S
S
D
W
Q
A
E
L
I
--
S
--
A
--
D
G
S
Q
--
F
T
V
S
F
N
D
--
N
KE
A
T
A
L
V
N
W
S
M
S
G
L
H
N
V
N
N
A
L
V
A
I
A
A
A
Y
N
I
G
V
S
V
K
T
A
C
A
A
L
S
A
F
A
G
I
K
R
R
M
E
L
I
G
----
D
---------
V
---
N
D
-
I
L
----
V
F
D
D
F
-
A
H
H
P
T
A
I
T
T
T
L
D
G
A
K
K
K
L
A
D
R
R
L
W
A
I
I
E
P
R
S
N
T
M
K
M
G
I
H
Q
D
S
L
A
Q
S
A
T
L
A
D
H
T
L
W
Y
------
E
P
T
G
L
------
E
W
G
L
K
-
E
V
I
D
N
-----
A
T
I
A
NPSI
G
S
----
Q
Q
V
-------
L
S
S
V
D
D
I
I
K
H
I
C
T
H
A
K
A
G
D
A
I
V
I
M
S
N
G
G
F
E
G
I
H
Q
R
L
L
T
A
L
-----
27
PsiBlast_PDB
63.08
55%
-43
- C2 -
-
3EAG
2
?
A:
[6-326]
-
H
I
H
I
I
G
I
G
G
T
F
M
G
G
L
A
A
I
A
K
E
A
G
F
E
V
S
G
C
D
A
K
M
Y
P
P
--
M
S
T
Q
-
L
E
A
L
G
I
D
V
Y
E
G
F
D
A
A
Q
L
D
E
-
F
K
A
D
V
Y
V
I
G
N
V
A
K
R
G
M
D
V
V
E
A
I
L
N
L
G
L
P
Y
I
S
G
P
Q
W
L
S
E
N
V
L
-
H
H
H
W
V
L
G
V
A
G
T
H
G
K
T
T
T
A
S
M
L
A
W
V
L
E
Y
A
G
L
A
P
G
F
L
I
G
-
G
V
P
E
----------
N
------
F
G
------
V
S
--------------
A
R
-
L
PQTPRQDPN
S
Q
S
P
----------
F
F
V
I
E
A
D
E
Y
D
T
A
F
F
D
K
R
S
K
F
V
H
Y
R
P
R
T
A
V
L
N
N
L
E
F
D
H
A
D
I
F
-
A
-
D
L
G
A
I
Q
T
Q
F
H
Y
L
V
R
T
V
P
S
E
G
L
I
V
C
N
G
R
Q
Q
S
L
Q
D
T
L
-
D
K
-----
G
C
-
W
--
T
P
V
E
K
F
G
T
--
E
H
-
G
W
Q
A
G
E
A
------
N
--
A
--
D
G
S
---
F
D
V
L
L
D
G
--
K
--
T
A
G
R
V
K
W
D
L
M
G
R
H
N
R
M
N
A
L
A
V
I
A
A
A
R
H
V
G
V
D
I
Q
T
A
C
E
A
L
G
A
F
K
N
V
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
62.73
27%
-58
- C2 -
-
4HV4
2
MURC_YERPE
B:
[23-482]
R
H
I
H
F
V
G
I
G
G
A
G
M
G
G
I
A
E
V
L
A
N
E
G
Y
Q
I
S
G
S
D
L
A
P
N
S
---
V
T
Q
H
-
L
T
A
L
G
A
Q
I
Y
F
H
H
R
P
E
N
V
---
L
D
A
S
V
V
V
V
S
T
A
I
S
A
D
N
P
E
I
V
A
A
R
E
A
R
I
P
V
I
R
R
A
E
M
L
A
E
L
M
R
--
Y
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
A
M
L
S
S
I
Y
A
E
A
G
L
D
P
T
F
V
N
G
-
G
L
V
K
----------
A
------
A
G
------
T
H
--------------
A
R
-
L
---------
G
S
S
R
----------
Y
L
I
A
E
A
D
E
S
D
A
S
F
-------
L
H
L
Q
P
M
V
A
I
V
T
N
I
E
A
D
--------
D
F
E
N
L
K
Q
T
F
I
N
F
L
H
N
L
P
F
Y
G
R
A
V
M
C
I
D
D
P
V
V
R
E
L
L
-
P
R
-----
V
G
R
H
--
I
T
T
Y
G
F
S
D
--
D
A
--
D
V
---
Q
I
A
S
Y
--
R
Q
E
G
--
P
Q
G
H
--
F
T
L
R
R
Q
D
--
K
--
P
L
I
E
V
T
L
N
A
P
G
R
H
N
A
L
N
A
A
A
A
V
A
V
A
T
E
E
G
I
E
D
E
D
I
L
R
A
L
V
G
F
Q
G
T
G
R
R
F
D
F
L
G
----
N
F
P
LAPVNGK
E
---
G
S
-
A
M
----
L
V
D
D
Y
-
G
H
H
P
T
E
V
D
A
T
I
K
A
A
R
A
G
W
P
D
K
R
I
V
M
L
F
Q
P
H
R
Y
T
R
T
R
D
L
Y
-
D
D
F
A
N
V
L
S
Q
V
D
V
L
L
M
L
------
D
V
Y
A
A
GEPPIP
G
A
D
S
R
-
A
L
C
R
T
-----
I
R
------
N
R
GKLD
P
I
L
-------
V
P
D
S
E
S
A
P
E
M
L
A
Q
I
L
N
G
E
D
L
I
L
V
Q
G
A
G
N
I
G
K
I
A
R
K
L
A
E
H
K
-----
3
HHSearch
62.17
27%
-52
- C2 -
-
2F00
-
MURC_ECOLI
B:
[20-480]
R
H
I
H
F
V
G
I
G
G
A
G
M
G
G
I
A
E
V
L
A
N
E
G
Y
Q
I
S
G
S
D
L
A
P
N
P
---
V
T
Q
Q
-
L
M
N
L
G
A
T
I
Y
F
N
H
R
P
E
N
V
---
R
D
A
S
V
V
V
V
S
S
A
I
S
A
D
N
P
E
I
V
A
A
H
E
A
R
I
P
V
I
R
R
A
E
M
L
A
E
L
M
R
--
F
R
H
G
I
A
I
A
G
T
H
G
K
T
T
T
T
A
M
V
S
S
I
Y
A
E
A
G
L
D
P
T
F
V
N
G
-
G
L
V
K
----------
A
------
A
G
------
V
H
--------------
A
R
-
L
---------
G
H
G
R
----------
Y
L
I
A
E
A
D
E
S
D
A
S
F
-------
L
H
L
Q
P
M
V
A
I
V
T
N
I
E
A
D
H
M
D
T
Y
-
Q
G
D
F
E
N
L
K
Q
T
F
I
N
F
L
H
N
L
P
F
Y
G
R
A
V
M
C
V
D
D
P
V
I
R
E
L
L
-
P
R
-----
V
G
R
Q
--
T
T
T
Y
G
F
S
E
--
D
A
--
D
V
---
R
V
E
D
Y
--
Q
--
Q
IG
P
Q
G
H
--
F
T
L
L
R
Q
D
--
K
--
E
P
M
R
V
T
L
N
A
P
G
R
H
N
A
L
N
A
A
A
A
V
A
V
A
T
E
E
G
I
D
D
E
A
I
L
R
A
L
E
S
F
Q
G
T
G
R
R
F
D
F
L
G
----
E
FPLEPVNG-
K
---
S
G
T
A
M
----
L
V
D
D
Y
-
G
H
H
P
T
E
V
D
A
T
I
K
A
A
R
A
G
W
P
D
K
N
L
V
M
L
F
Q
P
H
R
F
T
R
T
R
D
L
Y
-
D
D
F
A
N
V
L
T
Q
V
D
T
L
L
M
L
------
E
V
Y
P
A
GEAPIP
G
A
D
S
R
-
S
L
C
R
T
-----
I
R
------
G
R
GKID
P
I
L
-------
V
P
D
P
A
R
V
A
E
M
L
A
P
V
L
T
G
N
D
L
I
L
V
Q
G
A
G
N
I
G
K
I
A
R
S
L
A
E
I
K
L
----
7
HHSearch
61.45
26%
-51
- C2 -
-
1P3D
2
MURC_HAEIN
A:
[19-473]
Q
Q
I
H
F
I
G
I
G
G
A
G
M
S
G
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
G
V
---
V
T
Q
R
-
L
A
Q
A
G
A
K
I
Y
I
G
H
A
E
E
H
I
---
E
G
A
S
V
V
V
V
S
S
A
I
K
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
I
Q
R
A
Q
M
L
A
E
I
M
R
--
F
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
K
L
D
P
T
F
V
N
G
-
G
L
V
K
----------
S
------
A
G
------
K
N
--------------
A
H
-
L
---------
G
A
S
R
----------
Y
L
I
A
E
A
D
E
S
D
A
S
F
-------
L
H
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
E
G
-
D
F
E
K
M
K
A
T
Y
V
K
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
A
D
D
P
V
L
M
E
L
V
-
P
K
-----
V
G
R
Q
--
V
I
T
Y
G
F
S
E
--
Q
A
--
D
Y
---
R
I
E
D
Y
--
E
--
Q
T
G
F
Q
G
H
--
Y
T
V
I
C
P
N
--
N
--
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
E
F
I
R
P
---------
N
---
G
K
-
V
R
----
L
V
D
D
Y
-
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
-
D
D
F
V
Q
V
L
S
Q
V
D
A
L
I
M
L
------
D
V
Y
A
A
GEAPIV
G
A
D
S
K
-
S
L
C
R
S
-----
I
R
------
N
L
GK
V
D
P
I
L
-------
V
S
D
T
S
Q
L
G
D
V
L
D
Q
I
I
Q
D
G
D
L
I
L
A
Q
G
A
G
S
V
S
K
I
S
R
G
L
A
E
S
W
-----
8
HHSearch
61.25
26%
-50
- C2 -
-
1GQY
1
MURC_HAEIN
B:
[19-474]
Q
Q
I
H
F
I
G
I
G
G
A
G
M
S
G
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
G
V
---
V
T
Q
R
-
L
A
Q
A
G
A
K
I
Y
I
G
H
A
E
E
H
I
---
E
G
A
S
V
V
V
V
S
S
A
I
K
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
I
Q
R
A
Q
M
L
A
E
I
M
R
--
F
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
K
L
D
P
T
F
V
N
G
-
G
L
V
K
----------
S
------
A
G
------
K
N
--------------
A
H
-
L
---------
G
A
S
R
----------
Y
L
I
A
E
A
D
E
S
D
A
S
F
-------
L
H
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
E
G
-
D
F
E
K
M
K
A
T
Y
V
K
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
A
D
D
P
V
L
M
E
L
V
-
P
K
-----
V
G
R
Q
--
V
I
T
Y
G
F
S
E
--
Q
A
--
D
Y
---
R
I
E
D
Y
--
E
--
Q
T
G
F
Q
G
H
--
Y
T
V
I
C
P
N
--
N
--
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
E
F
I
R
P
---------
N
---
G
K
-
V
R
----
L
V
D
D
Y
-
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
-
D
D
F
V
Q
V
L
S
Q
V
D
A
L
I
M
L
------
D
V
Y
A
A
GEAPIV
G
A
D
S
K
-
S
L
C
R
S
-----
I
R
------
N
L
GK
V
D
P
I
L
-------
V
S
D
T
S
Q
L
G
D
V
L
D
Q
I
I
Q
D
G
D
L
I
L
A
Q
G
A
G
S
V
S
K
I
S
R
G
L
A
E
S
W
K
----
11
HHSearch
61.13
57%
-36
- C2 -
-
3EAG
2
?
B:
[5-326]
K
H
I
H
I
I
G
I
G
G
T
F
M
G
G
L
A
A
I
A
K
E
A
G
F
E
V
S
G
C
D
A
K
M
Y
P
P
--
M
S
T
Q
-
L
E
A
L
G
I
D
V
Y
E
G
F
D
A
A
Q
L
-
D
E
F
K
A
D
V
Y
V
I
G
N
V
A
K
R
G
M
D
V
V
E
A
I
L
N
L
G
L
P
Y
I
S
G
P
Q
W
L
S
E
N
V
L
-
H
H
H
W
V
L
G
V
A
G
T
H
G
K
T
T
T
A
S
M
L
A
W
V
L
E
Y
A
G
L
A
P
G
F
L
I
G
-
G
V
P
E
----------
N
------
F
G
VSARLP
Q
T
PRQ-----------
D
P
-
N
---------
S
Q
S
P
----------
F
F
V
I
E
A
D
E
Y
D
T
A
F
F
D
K
R
S
K
F
V
H
Y
R
P
R
T
A
V
L
N
N
L
E
F
D
H
A
D
I
F
-
A
-
D
L
G
A
I
Q
T
Q
F
H
Y
L
V
R
T
V
P
S
E
G
L
I
V
C
N
G
R
Q
Q
S
L
Q
D
T
L
-
D
K
-----
G
C
-
W
--
T
P
V
E
K
F
G
T
--
E
H
--
G
W
---
Q
A
G
E
A
--
N
-----
A
D
G
S
--
F
D
V
L
L
D
G
--
K
--
T
A
G
R
V
K
W
D
L
M
G
R
H
N
R
M
N
A
L
A
V
I
A
A
A
R
H
V
G
V
D
I
Q
T
A
C
E
A
L
G
A
F
K
N
V
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_PDB
56.69
28%
-29
- C2 -
-
4HV4
2
MURC_YERPE
A:
[46-478]
-----------------------
G
Y
Q
I
S
G
S
D
--
L
A
P
N
--
S
V
T
Q
-
H
L
T
A
L
G
A
Q
I
Y
F
H
H
R
P
E
N
-
V
-
L
D
A
S
V
V
V
V
S
T
A
I
S
A
D
N
P
E
I
V
A
A
R
E
A
R
I
P
V
I
R
R
A
E
M
L
A
E
-
L
M
-
R
Y
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
A
M
L
S
S
I
Y
A
E
A
G
L
D
P
T
F
V
N
G
-
G
L
V
K
----------
A
------
A
G
------
T
H
--------------
A
R
-
L
---------
G
S
S
R
----------
Y
L
I
A
E
A
D
E
S
D
A
S
-------
F
L
H
L
Q
P
M
V
A
I
V
T
N
I
E
A
D
H
M
D
T
Y
-
Q
G
D
F
E
N
L
K
Q
T
F
I
N
F
L
H
N
L
P
F
Y
G
R
A
V
M
C
I
D
D
P
V
V
R
E
L
L
P
R
V
-----
G
R
-
H
--
I
T
T
Y
G
F
S
D
--
D
A
-
D
V
Q
I
A
S
Y
R
Q
----
E
--
G
--
P
Q
G
H
--
F
T
L
R
R
Q
D
--
K
--
P
L
I
E
V
T
L
N
A
P
G
R
H
N
A
L
N
A
A
A
A
V
A
V
A
T
E
E
G
I
E
D
E
D
I
L
R
A
L
V
G
F
Q
G
T
G
R
R
F
D
F
L
G
----
N
F
P
LAP----
V
---
N
G
-
K
E
G
S
A
M
L
V
D
D
Y
-
G
H
H
P
T
E
V
D
A
T
I
K
A
A
R
A
G
W
P
D
K
R
I
V
M
L
F
Q
P
H
R
Y
T
-
R
T
R
D
L
Y
D
D
F
A
N
V
L
S
Q
V
D
V
L
L
M
L
D
VYAAG
E
P
P
I
P
------
G
A
D
S
R
-
A
L
C
R
T
-----
I
R
------
N
R
----
G
K
L
D
P
I
L
V
PD
S
E
S
A
P
E
M
L
A
Q
I
L
N
--
G
E
-
D
L
I
L
V
Q
G
A
G
N
I
G
K
I
A
R
K
L
---------
2
HHSearch
56.45
25%
-24
- C2 -
-
1J6U
-
MURC_THEMA
A:
[1-444]
M
K
I
H
F
V
G
I
G
G
I
G
M
S
A
V
A
L
H
E
F
S
N
G
N
D
V
Y
G
S
N
I
E
E
T
-
E
--
R
T
A
Y
-
L
R
K
L
G
I
P
I
F
V
P
H
S
A
D
N
W
---
Y
D
P
D
L
V
I
K
T
P
A
V
R
D
D
N
P
E
I
V
R
A
R
M
E
R
V
P
I
E
N
R
L
H
Y
F
R
D
T
L
K
R
E
K
K
E
E
F
A
V
T
G
T
D
G
K
T
T
T
T
A
M
V
A
H
V
L
K
H
L
R
K
S
P
T
V
F
L
G
-
G
I
M
D
----------
S
------
L
E
------
H
G
--------------
N
Y
-
E
---------
K
G
N
G
----------
P
V
V
Y
E
L
D
E
S
E
E
-
F
------
F
S
E
F
S
P
N
Y
L
I
I
T
N
A
R
G
D
H
L
E
N
Y
-
G
N
S
L
T
R
Y
R
S
A
F
E
K
I
S
R
N
T
---
D
L
V
V
T
F
A
E
D
E
L
T
S
H
L
G
--------------
D
V
T
F
G
V
K
K
---
G
--
T
Y
---
T
L
E
M
R
S
A
S
--
R
--
A
E
Q
K
--
A
M
V
E
K
N
G
--
K
--
R
Y
L
E
L
K
L
K
V
P
G
F
H
N
V
L
N
A
L
A
V
I
A
L
F
D
S
L
G
Y
D
L
A
P
V
L
E
A
L
E
E
F
R
G
V
H
R
R
F
S
I
A
F
----
H
DP-------
E
---
T
N
-
I
Y
----
V
I
D
D
Y
-
A
H
T
P
D
E
I
R
N
L
L
Q
T
A
K
E
V
F
E
N
E
K
I
V
V
I
F
Q
P
H
R
---------
G
N
F
A
K
A
L
Q
L
A
D
E
V
V
V
T
------
E
V
Y
D
---------
S
G
K
-
M
I
W
D
S
-----
L
K
------
S
L
G
K
E
-
A
Y
F
-------
V
E
K
L
P
E
L
E
K
V
I
-
S
-
V
S
E
N
T
V
F
L
F
V
G
A
G
D
I
I
Y
S
S
R
R
F
V
E
R
Y
Q
S
---
48
PsiBlast_CBE
55.07
31%
-77
- C2 -
-
5VVW
1
?
C:
[13-312]
----
F
V
G
I
G
G
A
G
M
C
G
I
A
E
V
L
L
N
L
G
Y
E
V
S
G
S
D
L
K
A
-
S
A
--
V
T
E
R
-
L
E
K
F
G
A
Q
I
F
I
G
H
Q
A
E
N
A
-
D
--
G
A
D
V
L
V
V
S
S
A
I
N
R
A
N
P
E
V
A
S
A
L
E
R
R
I
P
V
V
P
R
A
E
M
L
A
E
-
L
M
-
R
Y
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
S
L
I
A
S
V
F
A
A
G
G
L
D
P
T
F
V
I
G
-
G
R
L
N
----------
A
------
A
G
------
T
N
--------------
A
Q
-
L
---------
G
A
S
R
----------
Y
L
V
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
V
V
T
N
I
D
A
D
H
M
A
T
Y
G
G
-
D
F
N
K
L
K
K
T
F
V
E
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
V
D
D
P
V
V
R
E
I
L
-
P
Q
------
I
-
A
--
R
P
T
V
T
Y
G
L
-----
S
E
D
A
D
V
R
A
I
N
I
--
R
--
Q
--
E
G
M
R
TW
F
T
V
L
R
P
E
--
R
--
E
P
L
D
V
S
V
N
M
P
G
L
H
N
V
L
N
S
L
A
T
I
V
I
A
T
D
E
G
I
S
D
E
A
I
V
Q
G
L
S
G
F
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_PDB
54.48
31%
-76
- C2 -
-
5VVW
1
?
A:
[13-312]
----
F
V
G
I
G
G
A
G
M
C
G
I
A
E
V
L
L
N
L
G
Y
E
V
S
G
S
D
L
K
A
-
S
A
--
V
T
E
R
-
L
E
K
F
G
A
Q
I
F
I
G
H
Q
A
E
N
A
-
D
--
G
A
D
V
L
V
V
S
S
A
I
N
R
A
N
P
E
V
A
S
A
L
E
R
R
I
P
V
V
P
R
A
E
M
L
A
E
-
L
M
-
R
Y
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
S
L
I
A
S
V
F
A
A
G
G
L
D
P
T
F
V
I
G
-
G
R
L
N
----------
A
------
A
G
------
T
N
--------------
A
Q
-
L
---------
G
A
S
R
----------
Y
L
V
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
V
V
T
N
I
D
A
D
H
M
A
T
Y
G
G
-
D
F
N
K
L
K
K
T
F
V
E
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
V
D
D
P
V
V
R
E
I
L
-
P
Q
------
I
-
A
--
R
P
T
V
T
Y
G
L
-----
S
E
D
A
D
V
R
A
I
N
I
--
R
--
Q
--
E
G
M
R
T
W
F
T
V
L
R
P
E
--
R
--
E
P
L
D
V
S
V
N
M
P
G
L
H
N
V
L
N
S
L
A
T
I
V
I
A
T
D
E
G
I
S
D
E
A
I
V
Q
G
L
S
G
F
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
54.30
31%
-79
- C2 -
-
5VVW
1
?
B:
[13-312]
----
F
V
G
I
G
G
A
G
M
C
G
I
A
E
V
L
L
N
L
G
Y
E
V
S
G
S
D
L
K
A
-
S
A
--
V
T
E
R
-
L
E
K
F
G
A
Q
I
F
I
G
H
Q
A
E
N
A
-
D
--
G
A
D
V
L
V
V
S
S
A
I
N
R
A
N
P
E
V
A
S
A
L
E
R
R
I
P
V
V
P
R
A
E
M
L
A
E
-
L
M
-
R
Y
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
S
L
I
A
S
V
F
A
A
G
G
L
D
P
T
F
V
I
G
-
G
R
L
N
----------
A
------
A
G
------
T
N
--------------
A
Q
-
L
---------
G
A
S
R
----------
Y
L
V
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
V
V
T
N
I
D
A
D
H
M
A
T
Y
G
G
-
D
F
N
K
L
K
K
T
F
V
E
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
V
D
D
P
V
V
R
E
I
L
-
P
Q
------
I
-
A
--
R
P
T
V
T
Y
G
L
-----
S
E
D
A
D
V
R
A
I
N
I
--
R
--
Q
--
E
G
M
R
TW
F
T
V
L
R
P
E
--
R
--
E
P
L
D
V
S
V
N
M
P
G
L
H
N
V
L
N
S
L
A
T
I
V
I
A
T
D
E
G
I
S
D
E
A
I
V
Q
G
L
S
G
F
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
53.60
31%
-74
- C2 -
-
5VVW
3
?
G:
[13-312]
----
F
V
G
I
G
G
A
G
M
C
G
I
A
E
V
L
L
N
L
G
Y
E
V
S
G
S
D
L
K
A
-
S
A
--
V
T
E
R
-
L
E
K
F
G
A
Q
I
F
I
G
H
Q
A
E
N
A
-
D
--
G
A
D
V
L
V
V
S
S
A
I
N
R
A
N
P
E
V
A
S
A
L
E
R
R
I
P
V
V
P
R
A
E
M
L
A
E
-
L
M
-
R
Y
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
S
L
I
A
S
V
F
A
A
G
G
L
D
P
T
F
V
I
G
-
G
R
L
N
----------
A
------
A
G
------
T
N
--------------
A
Q
-
L
---------
G
A
S
R
----------
Y
L
V
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
V
V
T
N
I
D
A
D
H
M
A
T
Y
G
G
-
D
F
N
K
L
K
K
T
F
V
E
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
V
D
D
P
V
V
R
E
I
L
-
P
Q
------
I
-
A
--
R
P
T
V
T
Y
G
L
-----
S
E
D
A
D
V
R
A
I
N
I
--
R
--
Q
--
E
G
M
R
TW
F
T
V
L
R
P
E
--
R
--
E
P
L
D
V
S
V
N
M
P
G
L
H
N
V
L
N
S
L
A
T
I
V
I
A
T
D
E
G
I
S
D
E
A
I
V
Q
G
L
S
G
F
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
53.59
31%
-77
- C2 -
-
5VVW
1
?
H:
[13-312]
----
F
V
G
I
G
G
A
G
M
C
G
I
A
E
V
L
L
N
L
G
Y
E
V
S
G
S
D
L
K
A
-
S
A
--
V
T
E
R
-
L
E
K
F
G
A
Q
I
F
I
G
H
Q
A
E
N
A
-
D
--
G
A
D
V
L
V
V
S
S
A
I
N
R
A
N
P
E
V
A
S
A
L
E
R
R
I
P
V
V
P
R
A
E
M
L
A
E
-
L
M
-
R
Y
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
S
L
I
A
S
V
F
A
A
G
G
L
D
P
T
F
V
I
G
-
G
R
L
N
----------
A
------
A
G
------
T
N
--------------
A
Q
-
L
---------
G
A
S
R
----------
Y
L
V
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
A
V
V
T
N
I
D
A
D
H
M
A
T
Y
G
G
-
D
F
N
K
L
K
K
T
F
V
E
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
V
D
D
P
V
V
R
E
I
L
-
P
Q
------
I
-
A
--
R
P
T
V
T
Y
G
L
-----
S
E
D
A
D
V
R
A
I
N
I
--
R
--
Q
--
E
G
M
R
TW
F
T
V
L
R
P
E
--
R
--
E
P
L
D
V
S
V
N
M
P
G
L
H
N
V
L
N
S
L
A
T
I
V
I
A
T
D
E
G
I
S
D
E
A
I
V
Q
G
L
S
G
F
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
52.14
32%
-62
- C2 -
-
5VVW
3
?
G:
[9-312]
R
R
I
H
F
V
G
I
G
G
A
G
M
C
G
I
A
E
V
L
L
N
L
G
Y
E
V
S
G
S
D
L
K
A
S
A
---
V
T
E
R
-
L
E
K
F
G
A
Q
I
F
I
G
H
Q
A
E
N
A
---
D
G
A
D
V
L
V
V
S
S
A
I
N
R
A
N
P
E
V
A
S
A
L
E
R
R
I
P
V
V
P
R
A
E
M
L
A
E
L
M
R
--
Y
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
S
L
I
A
S
V
F
A
A
G
G
L
D
P
T
F
V
I
G
G
R
L
N
A
----------
A
-------
G
------
T
N
--------------
A
Q
-
L
---------
G
A
S
R
----------
Y
L
V
A
E
A
D
E
S
D
A
S
F
-------
L
H
L
Q
P
M
V
A
V
V
T
N
I
D
A
D
H
M
A
T
Y
-
G
G
D
F
N
K
L
K
K
T
F
V
E
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
V
D
D
P
V
V
R
E
I
L
-
P
Q
-----
I
--
A
--
R
P
T
V
T
Y
G
L
--
S
E
D
A
D
V
---
R
A
I
N
I
--
R
--
Q
EG
M
R
T
W
--
F
T
V
L
R
P
E
--
R
--
E
P
L
D
V
S
V
N
M
P
G
L
H
N
V
L
N
S
L
A
T
I
V
I
A
T
D
E
G
I
S
D
E
A
I
V
Q
G
L
S
G
F
Q
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_PDB
49.03
29%
-31
- C2 -
-
1GQY
1
MURC_HAEIN
A:
[20-375]
-
Q
I
H
F
I
G
I
G
G
A
G
M
S
G
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
--
I
A
D
G
--
V
V
T
Q
R
L
A
Q
A
G
A
K
I
Y
I
G
H
A
E
E
H
I
-
E
-
G
-
A
S
V
V
V
V
S
S
A
I
K
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
I
Q
R
A
Q
M
L
A
E
-
I
M
-
R
F
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
K
L
D
P
T
F
V
N
G
-
G
L
V
K
----------
S
------
A
G
------
K
N
--------------
A
H
-
L
---------
G
A
S
R
----------
Y
L
I
A
E
A
D
E
S
D
A
S
F
L
-------
H
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
--------
D
F
E
K
M
K
A
T
Y
V
K
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
A
D
D
P
V
L
M
E
L
V
-
P
K
-----
V
G
-
R
--
Q
V
I
T
Y
G
F
S
--
E
Q
-
A
D
Y
R
I
E
D
Y
E
Q
T
--
G
--
F
--
Q
G
-
H
--
Y
T
V
I
C
P
N
--
N
--
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
----
E
---------
F
I
R
P
N
G
K
V
R
----
L
V
D
D
Y
-
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
R
I
V
M
I
F
Q
P
---------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_PDB
47.54
28%
-4
- C2 -
-
1P3D
2
MURC_HAEIN
A:
[42-375]
-----------------------
G
Y
Q
I
S
G
S
D
--
I
A
D
G
--
V
V
T
Q
R
L
A
Q
A
G
A
K
I
Y
I
G
H
A
E
E
H
I
-
E
-
G
-
A
S
V
V
V
V
S
S
A
I
K
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
I
Q
R
A
Q
M
L
A
E
-
I
M
-
R
F
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
K
L
D
P
T
F
V
N
G
-
G
L
V
K
----------
S
------
A
G
------
K
N
--------------
A
H
-
L
---------
G
A
S
R
----------
Y
L
I
A
E
A
D
E
S
D
A
S
-------
F
L
H
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
-
E
G
D
F
E
K
M
K
A
T
Y
V
K
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
A
D
D
P
V
L
M
E
L
V
-
P
K
-----
V
G
-
R
--
Q
V
I
T
Y
G
F
S
--
E
Q
-
A
D
Y
R
I
E
D
Y
E
Q
T
--
G
--
F
--
Q
G
-
H
--
Y
T
V
I
C
P
N
--
N
--
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
----
E
---------
F
I
R
P
N
G
K
V
R
----
L
V
D
D
Y
-
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
R
I
V
M
I
F
Q
P
---------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_PDB
47.52
28%
1
- C2 -
-
1P31
1
MURC_HAEIN
A:
[42-375]
-----------------------
G
Y
Q
I
S
G
S
D
--
I
A
D
G
--
V
V
T
Q
R
L
A
Q
A
G
A
K
I
Y
I
G
H
A
E
E
H
I
-
E
-
G
-
A
S
V
V
V
V
S
S
A
I
K
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
I
Q
R
A
Q
M
L
A
E
-
I
M
-
R
F
R
H
G
I
A
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
K
L
D
P
T
F
V
N
G
-
G
L
V
K
----------
S
------
A
G
------
K
N
--------------
A
H
-
L
---------
G
A
S
R
----------
Y
L
I
A
E
A
D
E
S
D
A
S
-------
F
L
H
L
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
M
D
T
Y
-
E
G
D
F
E
K
M
K
A
T
Y
V
K
F
L
H
N
L
P
F
Y
G
L
A
V
M
C
A
D
D
P
V
L
M
E
L
V
-
P
K
-----
V
G
-
R
--
Q
V
I
T
Y
G
F
S
--
E
Q
-
A
D
Y
R
I
E
D
Y
E
Q
T
--
G
--
F
--
Q
G
-
H
--
Y
T
V
I
C
P
N
--
N
--
E
R
I
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
E
G
I
A
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
F
D
Q
L
G
----
E
---------
F
I
R
P
N
G
K
V
R
----
L
V
D
D
Y
-
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
R
I
V
M
I
F
Q
P
---------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
45.68
23%
13
- C2 -
-
3LK7
-
MURD_STRA5
A:
[10-427]
K
K
V
L
V
L
G
L
A
R
S
G
E
-
A
A
A
R
L
L
A
K
L
G
A
I
V
T
V
N
D
G
K
P
F
D
E
N
P
T
A
Q
S
-
L
L
E
E
G
I
K
V
V
C
G
S
H
P
L
E
L
-
L
D
E
D
F
C
Y
M
I
K
N
P
G
I
P
Y
N
N
P
M
V
K
K
A
L
E
K
Q
I
P
V
L
T
E
V
E
L
A
Y
L
V
S
---
E
S
Q
L
I
G
I
T
G
S
N
G
K
T
T
T
T
T
M
I
A
E
V
L
N
A
G
G
Q
R
-
G
L
L
A
G
-
N
I
G
F
----------
P
------
A
S
------
E
V
--------------
V
Q
A
A
---------
N
D
K
D
----------
T
L
V
M
E
L
S
S
F
Q
L
M
G
V
------
K
E
F
R
P
H
I
A
V
I
T
N
L
M
P
T
H
L
D
Y
H
-
G
-
S
F
E
D
Y
V
A
A
K
W
N
I
Q
N
Q
M
S
S
S
D
F
L
V
L
N
F
N
Q
G
I
S
K
E
L
A
-
K
T
------
T
-
K
--
A
T
I
V
P
F
S
T
--
T
E
K
V
D
G
-
A
-
Y
V
Q
----------
D
K
Q
L
--
F
--
Y
K
G
E
--
N
--
I
M
S
V
D
D
I
G
V
P
G
S
H
N
V
E
N
A
L
A
T
I
A
V
A
K
L
A
G
I
S
N
Q
V
I
R
E
T
L
S
N
F
G
G
V
K
H
R
L
Q
S
L
G
----
K
---------
V
---
H
G
-
I
S
----
F
Y
N
D
S
K
S
T
N
I
L
A
T
Q
K
A
L
S
G
F
D
N
----
T
K
V
I
L
I
A
G
G
L
D
R
G
---
N
E
F
-
D
E
L
I
P
D
I
T
G
L
K
H
M
V
V
L
------
G
E
S
A
S
------
R
------
V
K
R
A
-----
A
Q
------
K
A
G
V
T
-
Y
S
D
-------
A
L
D
V
R
D
A
V
H
K
A
Y
E
V
A
Q
Q
G
D
V
I
L
L
S
P
A
N
A
S
----------------